Research Topics
Species | Pasquale SantangeliSummaryCountry: Italy Publications
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Publications
Meta-analysis: age and effectiveness of prophylactic implantable cardioverter-defibrillatorsPasquale Santangeli
Catholic University of the Sacred Heart, Rome, Italy
Ann Intern Med 153:592-9. 2010..Implantable cardioverter-defibrillators (ICDs) for the primary prevention of sudden cardiac death have been proven effective in several clinical trials...
Outcome of invasive electrophysiological procedures and gender: are males and females the same?Pasquale Santangeli
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
J Cardiovasc Electrophysiol 22:605-12. 2011..On the other hand, the clinical outcome after cardiac resynchronization therapy seems to be more favorable in women, who experience a greater degree of reverse left ventricular remodeling...
Left ventricular ejection fraction for the risk stratification of sudden cardiac death: friend or foe?P Santangeli
Institute of Cardiology, Catholic University of the Sacred Heart, Rome Arrhythmia Department, Institute of Cardiology, University of Milan, IRCCS Centro Cardiologico Monzino, Milan, Italy
Intern Med J 41:55-60. 2011..The aim of this viewpoint is to critically revise the value of ejection fraction in the identification of patients at risk of sudden cardiac death...
Imaging of scar in patients with ventricular arrhythmias of right ventricular origin: cardiac magnetic resonance versus electroanatomic mappingPasquale Santangeli
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
J Cardiovasc Electrophysiol 22:1359-66. 2011..Recently, electroanatomic mapping (EAM) has been shown to reliably detect scars corresponding to different cardiomyopathic substrates. We compared LGE with EAM for the detection of scar in patients with arrhythmias of RV origin...
Noninvasive diagnosis of electroanatomic abnormalities in arrhythmogenic right ventricular cardiomyopathyPasquale Santangeli
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
Circ Arrhythm Electrophysiol 3:632-8. 2010..We tested the association between noninvasive diagnostic criteria for ARVC and the presence of low-voltage areas (LVAs) detected at electroanatomic voltage mapping (EAM)...
Gender differences in clinical outcome and primary prevention defibrillator benefit in patients with severe left ventricular dysfunction: a systematic review and meta-analysisPasquale Santangeli
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
Heart Rhythm 7:876-82. 2010..Women are underrepresented in primary prevention implantable cardioverter-defibrillator (ICD) trials, and data on the benefit of ICD therapy in this subgroup are controversial...
Usefulness of statins in preventing atrial fibrillation in patients with permanent pacemaker: a systematic reviewPasquale Santangeli
Institute of Cardiology, Catholic University of the Sacred Heart, Largo A Gemelli, 8, 00168 Rome, Italy
Europace 12:649-54. 2010..Basing on our findings, a randomized clinical trial with a proper design to evaluate the utility of statins in preventing AF in these patients is warranted...
Ventricular late potentials: a critical overview and current applicationsPasquale Santangeli
Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, 00168 Roma, Italy
J Electrocardiol 41:318-24. 2008..The strength of VLPs is their high negative predictive value. When positive, VLPs still help better stratify the arrhythmic risk of patients in several clinical settings...
Cardiac resynchronization therapy in patients with mild heart failure: a systematic review and meta-analysisPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, TX, USA
J Interv Card Electrophysiol 32:125-35. 2011..Our objective is to summarize the available evidence on the effects of CRT in asymptomatic or mildly symptomatic (NYHA I-II) heart failure patients...
Acute left atrial thrombosis during anticoagulant therapy in a patient with antithrombin deficiencyPasquale Santangeli
Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Rome, Italy
Acta Cardiol 63:635-7. 2008..After 1 month of follow-up the patient underwent TEE which showed a dramatic reduction of the left atrial thrombosis. Our patient is doing well and is continuing life-long anticoagulant therapy...
Immunosuppressive and antiviral treatment of inflammatory cardiomyopathyPasquale Santangeli
Cardiovascular Department, Catholic University, Largo A Gemelli 8, Rome, Italy
Recent Pat Cardiovasc Drug Discov 4:88-97. 2009..The present review summarizes the recent advances in the diagnosis and risk stratification of ICMP, and reviews patents and treatment options for these patients...
Impact of metabolic syndrome on procedural outcomes in patients with atrial fibrillation undergoing catheter ablationSanghamitra Mohanty
St David s Medical Center, Texas Cardiac Arrhythmia Institute, Austin, TX 78705, USA
J Am Coll Cardiol 59:1295-301. 2012..The aim of this study was to investigate impact of metabolic syndrome (MS) on outcomes of catheter ablation in patients with atrial fibrillation (AF) in terms of recurrence and quality of life (QoL)...
Endo-epicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathyLuigi Di Biase
Texas Cardiac Arrhythmia Institute at St David s Medical Center, Austin, TX 78705, USA
J Am Coll Cardiol 60:132-41. 2012..This study investigated the impact on recurrences of 2 different substrate approaches for the treatment of these arrhythmias...
Catheter ablation of atrial fibrillation in octogenarians: safety and outcomesPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas 78705, USA
J Cardiovasc Electrophysiol 23:687-93. 2012..We report the safety and outcomes of RFCA of AF in octogenarians...
Correlation between signal-averaged ECG and the histologic evaluation of the myocardial substrate in right ventricular outflow tract arrhythmiasPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, TX 78705, USA
Circ Arrhythm Electrophysiol 5:475-83. 2012..We tested the association between SAECG and the myocardial substrate underlying RVOT-VAs...
Identifying the relationship between the non-PV triggers and the critical CFAE sites post-PVAI to curtail the extent of atrial ablation in longstanding persistent AFClaude S Elayi
University of Kentucky, Lexington, Kentucky, USA
J Cardiovasc Electrophysiol 22:1199-205. 2011..The mechanism underlying the clinical benefit of CFAE ablation remains, however, poorly understood...
Ablation of atrial fibrillation under therapeutic warfarin reduces periprocedural complications: evidence from a meta-analysisPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, TX 78705, USA
Circ Arrhythm Electrophysiol 5:302-11. 2012..We systematically reviewed the available evidence on the impact of CW compared with DW on periprocedural complications of AF catheter ablation...
Fragmented and delayed electrograms within fibrofatty scar predict arrhythmic events in arrhythmogenic right ventricular cardiomyopathy: results from a prospective risk stratification studyPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas 78705, USA
Heart Rhythm 9:1200-6. 2012..Islets of myocytes within fibrofatty scars represent the substrate for reentrant ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC). Electroanatomic mapping can reliably identify such areas...
Intraprocedural and long-term incomplete occlusion of the left atrial appendage following placement of the WATCHMAN device: a single center experienceRong Bai
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, TX 78705, USA
J Cardiovasc Electrophysiol 23:455-61. 2012..However, the incidence and evolution of incomplete occlusion of the LAA during and after placement of the WATCHMAN device has not been reported...
Drug-refractory ventricular tachycardias after myocarditis: endocardial and epicardial radiofrequency catheter ablationAntonio Dello Russo
Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino IRCCS, Milan, Italy
Circ Arrhythm Electrophysiol 5:492-8. 2012..Ventricular tachycardia (VT) is a significant therapeutic challenge in patients with myocarditis. This study aimed to assess the efficacy and safety of radiofrequency catheter ablation (RFCA) of VT in patients with myocarditis...
"Near-zero" fluoroscopic exposure in supraventricular arrhythmia ablation using the EnSite NavX™ mapping system: personal experience and review of the literatureMichela Casella
Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Milan, Italy
J Interv Card Electrophysiol 31:109-18. 2011..We aim to demonstrate the feasibility and safety of such an approach in young and middle-aged patients...
Transseptal access and atrial fibrillation ablation guided by intracardiac echocardiography in patients with atrial septal closure devicesPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas, USA
Heart Rhythm 8:1669-75. 2011....
Quality of life and patient-centered outcomes following atrial fibrillation ablation: short- and long-term perspectives to improving careSanghamitra Mohanty
St David s Medical Center, Texas Cardiac Arrhythmia Institute, Austin, TX, USA
Expert Rev Cardiovasc Ther 10:889-900. 2012..This article reviews all the information that has been contributed by prominent independent researchers over the last decade...
Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart: role of cardiac electroanatomical mapping and biopsyAntonio Dello Russo
Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino IRCCS, Milan, Italy
Heart Rhythm 8:1915-22. 2011..Three-dimensional electroanatomic mapping (EAM) has been demonstrated to reliably identify low-voltage areas that correspond to different cardiomyopathic substrates...
Catheter ablation of atrial fibrillation: state-of-the-art techniques and future perspectivesPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas, USA
J Cardiovasc Med (Hagerstown) 13:108-24. 2012..This article will summarize the state-of-the art techniques for atrial fibrillation ablation, and will discuss the contribution of ongoing studies to the future of atrial fibrillation ablation...
Reversible atrial gap junction remodeling during hypoxia/reoxygenation and ischemia: a possible arrhythmogenic substrate for atrial fibrillationAnna Severino
Institute of Cardiology, Catholic University of Sacred Heart, Rome, Italy
Gen Physiol Biophys 31:439-48. 2012..These alterations characterize several conditions and might contribute to the generation of an arrhythmogenic substrate leading to AF onset and/or maintenance...
Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter studyLuigi Di Biase
Texas Cardiac Arrhythmia Institute at St David s Medical Center, Austin, Texas 78705, USA
J Am Coll Cardiol 60:531-8. 2012....
Catheter ablation of atrial fibrillation: randomized controlled trials and registries, a look back and the view forwardPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, TX 78705, USA
J Interv Card Electrophysiol 31:69-80. 2011..This article will provide an overview of AF ablation trials that have constituted the basis for current clinical practice and will discuss the contribution of ongoing studies and registries to the future of AF ablation...
Role of tissue C-reactive protein in atrial cardiomyocytes of patients undergoing catheter ablation of atrial fibrillation: pathogenetic implicationsMaria Lucia Narducci
Institute of Cardiology, Catholic University of Sacred Heart, Rome, Italy
Europace 13:1133-40. 2011..We describe a novel and safe technique of atrial biopsy during AF radiofrequency catheter ablation (RFCA) to investigate the role of atrial tissue inflammation...
Predictors of impaired heart rate variability and clinical outcome in patients with acute myocardial infarction treated by primary angioplastyClaudio Larosa
Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Roma, Italy
J Cardiovasc Med (Hagerstown) 9:76-80. 2008..To investigate the determinants and prognostic value of heart rate variability (HRV) in acute myocardial infarction (AMI) patients treated by percutaneous coronary intervention (PCI)...
Periprocedural stroke and management of major bleeding complications in patients undergoing catheter ablation of atrial fibrillation: the impact of periprocedural therapeutic international normalized ratioLuigi Di Biase
Executive Texas Cardiac Arrhythmia Institute, St David s Medical Center, 1015 E 32th St, Suite 516, Austin, TX 78705, USA
Circulation 121:2550-6. 2010....
Safety and effectiveness of transvenous lead extraction in octogenariansGemma Pelargonio
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
J Cardiovasc Electrophysiol 23:1103-8. 2012..The safety and effectiveness of lead extraction in elderly patients has not been well evaluated. We report the safety and effectiveness of transvenous lead extraction in octogenarians...
Rationale and design of the NO-PARTY trial: near-zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias in young patientsMichela Casella
Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino IRCCS, Milan, Italy
Cardiol Young 22:539-46. 2012....
Examining the safety of amiodaronePasquale Santangeli
St David s Medical Center, Texas Cardiac Arrhythmia Institute, Austin, USA
Expert Opin Drug Saf 11:191-214. 2012..001 versus NNH for either thyroid toxicity, hepatic toxicity, pulmonary toxicity or bradycardia = 14; p < 0.001). Amiodarone treatment in this setting should be used in only selected cases...
Left atrial appendage: an underrecognized trigger site of atrial fibrillationLuigi Di Biase
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Tex 78705, USA
Circulation 122:109-18. 2010..The left atrial appendage (LAA) is an underestimated site of initiation of atrial fibrillation. Here, we report the prevalence of triggers from the LAA and the best strategy for successful ablation...
Usefulness of intracardiac echocardiography for the diagnosis of cardiovascular implantable electronic device-related endocarditisMaria Lucia Narducci
Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
J Am Coll Cardiol 61:1398-405. 2013..The goal of this study was to compare transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) for the diagnosis of cardiac device-related endocarditis (CDI)...
Atrial fibrillation and the risk of incident dementia: A meta-analysisPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas University of Foggia, Foggia, Italy
Heart Rhythm 9:1761-1768.e2. 2012..However, epidemiologic studies exploring the association between AF and incident dementia have reported conflicting results...
Ablation of ventricular arrhythmias in arrhythmogenic right ventricular dysplasia/cardiomyopathy: arrhythmia-free survival after endo-epicardial substrate based mapping and ablationRong Bai
Texas Cardiac Arrhythmia Institute at St David s Medical Center, Austin, TX, USA
Circ Arrhythm Electrophysiol 4:478-85. 2011..We compared the long-term freedom from recurrent VAs by using endocardial-alone ablation versus endo-epicardial substrate-based ablation...
Safety and outcomes of cryoablation for ventricular tachyarrhythmias: results from a multicenter experienceLuigi Di Biase
Texas Cardiac Arrhythmia Institute at St David s Medical Center, Austin, Texas, USA
Heart Rhythm 8:968-74. 2011..Catheter ablation of ventricular arrhythmias (VAs) with cryoenergy has not been widely reported...
Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: safety and feasibilityPasquale Santangeli
Texas Cardiac Arrhythmia Institute at St David Medical Center, University of Texas, Austin, Texas 78705, USA
Heart Rhythm 7:1036-42. 2010..Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging...
Results From a Single-Blind, Randomized Study Comparing the Impact of Different Ablation Approaches on Long-Term Procedure Outcome in Coexistent Atrial Fibrillation and Flutter (APPROVAL)Sanghamitra Mohanty
FHRS, FECC, Texas Cardiac Arrhythmia Institute, St David s Medical Center, 3000 N I 35, Ste 720, Austin, TX 78705
Circulation 127:1853-60. 2013..This study examined the impact of different ablation strategies on atrial fibrillation (AF) recurrence and quality of life in coexistent AF and atrial flutter (AFL)...
Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysisSanghamitra Mohanty
St David s Medical Center, Texas Cardiac Arrhythmia Institute, Austin, Texas 78705, USA
J Cardiovasc Electrophysiol 24:155-61. 2013..We aimed to explore the association of rs2200733 with AF through a systematic review and meta-analysis...
Advances in catheter ablation: atrial fibrillation ablation in patients with mitral mechanical prosthetic valvePasquale Santangeli
Texas Cardiac Arrhythmia Institute St David s Medical Center, Austin, TX 78705, USA
Curr Cardiol Rev 8:362-7. 2012..These data would encourage the adoption of RFCA of AF in MVR patients mostly by more experienced Institutions...
Prevalence and clinical significance of collateral findings detected by chest computed tomography in patients undergoing atrial fibrillation ablationMichela Casella
Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino IRCCS, Milan, Italy
Europace 14:209-16. 2012..Chest CT scans visualize organs other than the heart and collateral findings may be identified incidentally. Our study aims to assess the prevalence and clinical relevance of such collateral findings in patients undergoing AF ablation...
The pharmaceutical pipeline for atrial fibrillationPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, TX 78705, USA
Ann Med 43:13-32. 2011..In this article, we will focus on recent advances in antiarrhythmic therapy for AF, reviewing the possible clinical utility of novel antifibrillatory agents...
Novel agents for the acute conversion of atrial fibrillation: focus on vernakalantPio Cialdella
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
Recent Pat Cardiovasc Drug Discov 6:1-8. 2011..This article will review the recent patents on this novel atrial-selective agent, discussing its mechanisms of action and possible clinical applications in the real-world practice...
General anesthesia reduces the prevalence of pulmonary vein reconnection during repeat ablation when compared with conscious sedation: results from a randomized studyLuigi Di Biase
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas 78705, USA
Heart Rhythm 8:368-72. 2011..Radiofrequency catheter ablation of atrial fibrillation can be performed under general anesthesia or conscious sedation at the physician's preference...
[Catheter ablation as first-line therapy for atrial fibrillation: an analysis of available evidence]Pasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas, USA
G Ital Cardiol (Rome) 14:12-8. 2013..According to these results, catheter ablation could be considered as first-line therapy for patients with symptomatic paroxysmal atrial fibrillation without significant heart disease...
Closed loop stimulation is effective in improving heart rate and blood pressure response to mental stress: report of a single-chamber pacemaker study in patients with chronotropic incompetent atrial fibrillationRiccardo Proietti
Cardiac Electrophysiology Laboratory, Luigi Sacco Hospital, Milan, Italy
Pacing Clin Electrophysiol 35:990-8. 2012..To test its effectiveness, CLS and accelerometer sensor (AS) rate response were compared intraindividually during a mental stress test (MST)...
Endo-epicardial ablation of ventricular arrhythmias in the left ventricle with the Remote Magnetic Navigation System and the 3.5-mm open irrigated magnetic catheter: results from a large single-center case-control seriesLuigi Di Biase
Texas Cardiac Arrhythmia Institute at St David Medical Center, Austin, Texas, USA
Heart Rhythm 7:1029-35. 2010..Remote magnetic navigation (RMN) has been reported as a feasible and safe mapping and ablation system for treatment of ventricular arrhythmias (VAs). However, the reported success rates have been limited with the 4- and 8-mm catheter tips...
Exercise-induced ST-segment elevation in patients with a recent acute myocardial infarction treated by primary percutaneous coronary interventionFabio Infusino
Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Rome, Italy
Ann Noninvasive Electrocardiol 12:349-53. 2007..To get insight in the mechanism of exercise-induced ST-segment elevation (STE) in patients with Q/QS waves at the electrocardiogram (ECG)...
Atrial Fibrillation Ablation without Interruption of AnticoagulationPasquale Santangeli
Texas Cardiac Arrhythmia Institute, St David s Medical Center, 1015 East 32nd Street, Suite 516, Austin, TX 78705, USA
Cardiol Res Pract 2011:837841. 2011..Therefore, continuation of therapeutic warfarin during ablation of AF appears to be the best anticoagulation strategy. In this paper we summarize our experience with AF ablation without interruption of anticoagulation...
How to ablate long-standing persistent atrial fibrillation?Luigi Di Biase
Texas Cardiac Arrhythmia Institute, St David s Medical Center, Austin, Texas, USA
Curr Opin Cardiol 28:26-35. 2013..Several approaches with various outcomes have been described in the literature. The purpose of this review is to summarize the ablation approach that we developed at our institution...
