Research Topics
Species | Alessandro ZerbiSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Detail Information
Publications
Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection?Alessandro Zerbi
Pancreas Unit, Department of Surgery, S Raffaele Scientific Institute, V Olgettina 60, 20132, Milan, Italy
Ann Surg Oncol 15:1161-8. 2008..Pancreas is a possible site of metastases from renal cell carcinoma (RCC). The aim of this study was to define the role of surgery in their treatment...- Clinicopathological features of pancreatic endocrine tumors: a prospective multicenter study in Italy of 297 sporadic casesAlessandro Zerbi
Department of Surgery, Pancreas Unit, San Raffaele Scientific Institute, Milan, Italy
Am J Gastroenterol 105:1421-9. 2010..The aim of the study was to describe the clinical and pathological features of PETs in a prospective, multicenter study... - Adjuvant PEFG (cisplatin, epirubicin, 5-fluorouracil, gemcitabine) or gemcitabine followed by chemoradiation in pancreatic cancer: a randomized phase II trialMichele Reni
Department of Oncology, S Raffaele Scientific Institute, Milan, Italy
Ann Surg Oncol 19:2256-63. 2012..This randomized phase II trial aimed to identify the most promising regimen warranting phase III evaluation... - Surgical treatment of pancreatic endocrine tumours in Italy: results of a prospective multicentre study of 262 casesAlessandro Zerbi
Pancreatic Surgery Section, Humanitas Scientific Institute, Via Manzoni 56, Rozzano, Milan, Italy
Langenbecks Arch Surg 396:313-21. 2011..Information on the treatment of pancreatic endocrine tumours (PETs) comes mostly from small, retrospective, uncontrolled studies... 
Final results of a prospective trial of a PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) regimen followed by radiotherapy after curative surgery for pancreatic adenocarcinomaMichele Reni
Department of Radiochemotherapy, S Raffaele H Scientific Institute, Milan, Italy
Oncology 68:239-45. 2005..Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial...- Surgical management of insulinomas: short- and long-term outcomes after enucleations and pancreatic resectionsStefano Crippa
Department of Surgery, Chirurgia Generale B, Policlinico GB Rossi, University of Verona, Piazzale LA Scuro, 10 37134, Verona, Italy
Arch Surg 147:261-6. 2012..To analyze the characteristics and outcomes following enucleation and pancreatic resections of insulinomas... - Efficacy of an absorbable fibrin sealant patch (TachoSil) after distal pancreatectomy: a multicenter, randomized, controlled trialMarco Montorsi
Department of General Surgery, University of Milan, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
Ann Surg 256:853-9; discussion 859-60. 2012..To evaluate the role of an absorbable fibrin sealant patch (TachoSil) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP)... - Carbohydrate antigen 19-9 change during chemotherapy for advanced pancreatic adenocarcinomaMichele Reni
Department of Oncology, S Raffaele Scientific Institute, Milan, Italy
Cancer 115:2630-9. 2009..The objective of this study was to evaluate the correlation between a decline in carbohydrate antigen 19-9 (CA 19-9) and survival in patients with advanced pancreatic cancer who received upfront chemotherapy... - Effect of surgeon volume on outcome following pancreaticoduodenectomy in a high-volume hospitalNicolò Pecorelli
Department of Surgery, San Raffaele Hospital, Vita Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy
J Gastrointest Surg 16:518-23. 2012..The aim of this study is to assess the independent impact of surgeon volume on outcome after PD in a single high-volume institution... - Intraoperative ultrasound with contrast medium in resective pancreatic surgery: a pilot studyAntonino Spinelli
Unità Operativa e Cattedra di Chirurgia Generale, Universita degli Studi di Milano, Istituto Clinico Humanitas IRCCS, Via Alessandro Manzoni 56, 20089, Rozzano, Milan, Italy
World J Surg 35:2521-7. 2011..The purpose of the present study was to prospectively evaluate the possible role of contrast-enhanced intraoperative ultrasound (CEIOUS) during resective pancreatic surgery for primary lesion characterization and intraoperative staging... - Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4Federica Marchesi
Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
Cancer Res 64:8420-7. 2004..CXCR4 not only stimulates cell motility and invasion but also promotes survival and proliferation. Strategies to target CXCR4 expressed on tumor cells may be of benefit in patients with pancreatic cancer... - Parenchyma-preserving resections for small nonfunctioning pancreatic endocrine tumorsMassimo Falconi
Chirurgia Generale B Pancreas Unit, Department of Surgery, University of Verona, Policlinico GB Rossi, Verona, Italy
Ann Surg Oncol 17:1621-7. 2010..The aim of this study was to evaluate perioperative and long-term outcomes after PPRs for NF-PETs... 
Surgical management of acute pancreatitis in Italy: lessons from a prospective multicentre studyPaolo De Rai
Department of Surgery and Emergency Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Institute for Scientific Care and Treatment Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
HPB (Oxford) 12:597-604. 2010..This study aimed to evaluate the surgical treatment of acute pancreatitis in Italy and to assess compliance with international guidelines...- The unsolved problem of fistula after left pancreatectomy: the benefit of cautious drain managementGianpaolo Balzano
Pancreas Unit, Department of Surgery, San Raffaele Milan, Italy
J Gastrointest Surg 9:837-42. 2005..7%). In conclusion, fistula is an unsolved problem of left pancreatectomy. However, a careful drain management allows a good outcome in patients with fistula... - What is the role of pancreas units today?Valerio Di Carlo
Department of Surgery, University Vita Salute, San Raffaele Hospital, Milan Italy
JOP 7:101-3. 2006..We think that the adoption of a Pancreas Unit model could represent the right answer to the recent changes observed in Medicine and could offer a better approach to patients with pancreatic diseases... - Irrelevance of microsatellite instability in the epidemiology of sporadic pancreatic ductal adenocarcinomaLuigi Laghi
Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
PLoS ONE 7:e46002. 2012..Aims of the study were to determine the prevalence of MSI in surgically resected pancreatic cancers in a multicentric, retrospective study, and to assess the occurrence of pancreatic cancer in LS... - Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative gradingCecilia Piani
General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Via Olgettina 60, Milano, Italy
Endocr Relat Cancer 15:175-81. 2008..65, 95% CI: 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples... - Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10highIL-12low regulatory dendritic cellPaolo Monti
Laboratory of Experimental Surgery, Surgical Department, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
J Immunol 172:7341-9. 2004..These findings identify mucin secretion as a novel mechanism of tumor escape from immune surveillance and provide the basis for the generation of potentially tolerogenic DC... - Intraductal papillary mucinous tumors of the pancreas: incidence, clinical findings and natural historyGianpaolo Balzano
Pancreas Unit, Department of Surgery, S. Raffaele Hospital, Milan, Italy
JOP 6:108-11. 2005 - Double self-expandable total-coated metal stent for gastrojejunal leak after pancreatoduodenectomyEnzo Masci
Division of Gastroenterology and Gastrointestinal Endoscopy, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy
Gastrointest Endosc 66:1024-5. 2007 - Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumorsFrancesca Galbiati
Department of Medicine, San Raffaele Scientific Institute, Milan 20132, Italy
Endocrinology 143:4018-30. 2002..Together, these findings provide the rationale for testing the efficacy of calcitriol in the treatment of patients with solid beta-cell tumors... - Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trialMichele Reni
Department of Radiochemotherapy, S Raffaele H Scientific Institute, Milan, Italy
Lancet Oncol 6:369-76. 2005..We aimed to assess whether a four-drug regimen could improve 4 month progression-free survival compared with gemcitabine alone... - Strategies for tumor immune escapeLorenzo Piemonti
Laboratory of Experimental Surgery, Department of Surgery II, Fondazione Centro S Raffaele del Monte Tabor, Milan, Italy
Drugs Today (Barc) 39:701-24. 2003..The purpose of this review is to evaluate the current status of knowledge concerning these different tumor-escape strategies... - Cancer risk among the relatives of patients with pancreatic ductal adenocarcinomaMarco Del Chiaro
Regional Referral Center for Pancreatic Diseases Treatment, University of Pisa, Pisa, Italy
Pancreatology 7:459-69. 2007..Our aims were to examine familial aggregations of pancreas and other cancers, and to determine the relative risk of the family members... - Occlusion of the pancreatic duct versus pancreaticojejunostomy: a prospective randomized trialKhe Tran
Departments of General Surgery, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
Ann Surg 236:422-8; discussion 428. 2002..CONCLUSIONS: Duct occlusion without pancreaticojejunostomy does not reduce postoperative complications but significantly increases the risk of endocrine pancreatic insufficiency after duct occlusion... - Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancersLuigi Laghi
Division of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Milan, 20089 Italy
Oncogene 21:4301-6. 2002..Results show that multiple K-RAS mutations are frequent both in PC with associated PanIN and in biliary cancers, and indicate that clonally distinct precursor lesions of PC might variably contribute to tumor development... - A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profilePaolo Monti
Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Virchows Arch 445:236-47. 2004..In conclusion, a clear correlation between structural/genetic features and function could not be detected, suggesting the weakness of a "morphological" classification for the in vitro studies of pancreatic cancer... - Spleen-preserving distal pancreatectomy with excision of splenic artery and vein: a cautionary noteGianpaolo Balzano
World J Surg 31:1530; author reply 1531. 2007 - The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activityPaolo Monti
Laboratory of Experimental Surgery, Department of Surgery II, Fondazione Centro S Raffaele del Monte Tabor, Via Olgettina 60, 20132 Milan, Italy
Cancer Res 63:7451-61. 2003..On the whole, the results presented in our investigation suggest that CCL2 could be a relevant negative regulator of pancreatic cancer progression...