R Zanardi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Venlafaxine versus fluvoxamine in the treatment of delusional depression: a pilot double-blind controlled study
    R Zanardi
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychiatry 61:26-9. 2000
  2. ncbi Sertraline versus fluvoxamine in the treatment of elderly patients with major depression: a double-blind, randomized trial
    David Rossini
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    J Clin Psychopharmacol 25:471-5. 2005
  3. ncbi A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia
    R Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Eur Neuropsychopharmacol 16:281-7. 2006
  4. ncbi New perspectives on techniques for the clinical psychiatrist: Brain stimulation, chronobiology and psychiatric brain imaging
    Raffaella Zanardi
    San Raffaele Hospital Department of Psychiatry, Vita Salute University, Milan, Italy
    Psychiatry Clin Neurosci 62:627-37. 2008
  5. ncbi Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression
    Raffaella Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, Milan 20127, Italy
    Eur Neuropsychopharmacol 17:651-7. 2007
  6. ncbi Comparison of response to fluvoxamine in nondemented elderly compared to younger patients affected by major depression
    Raffaella Zanardi
    Department of Psychiatry San Raffaele Institute, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychopharmacol 23:535-9. 2003
  7. ncbi Response to SSRIs and role of the hormonal therapy in post-menopausal depression
    R Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele Hospital, Via Stamira d Ancona 20, Milan 20127, Italy
    Eur Neuropsychopharmacol 17:400-5. 2007
  8. ncbi Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: a positron emission tomography scan study
    R Zanardi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychopharmacol 21:53-8. 2001
  9. ncbi Faster onset of action of fluvoxamine in combination with pindolol in the treatment of delusional depression: a controlled study
    R Zanardi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychopharmacol 18:441-6. 1998
  10. ncbi Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression
    R Zanardi
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Prinetti, Milan 29 20127, Italy
    Biol Psychiatry 50:323-30. 2001

Detail Information

Publications45

  1. ncbi Venlafaxine versus fluvoxamine in the treatment of delusional depression: a pilot double-blind controlled study
    R Zanardi
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychiatry 61:26-9. 2000
    ....
  2. ncbi Sertraline versus fluvoxamine in the treatment of elderly patients with major depression: a double-blind, randomized trial
    David Rossini
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    J Clin Psychopharmacol 25:471-5. 2005
    ..Given the lack of literature data regarding fluvoxamine in the treatment of depressed elderly patients, the aim of the present study was to compare its efficacy and tolerability with those of sertraline in a sample of elderly patients...
  3. ncbi A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia
    R Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Eur Neuropsychopharmacol 16:281-7. 2006
    ..The greater tolerability of ALCAR is of clinical relevance considering the chronicity of dysthymia, which often requires prolonged treatment...
  4. ncbi New perspectives on techniques for the clinical psychiatrist: Brain stimulation, chronobiology and psychiatric brain imaging
    Raffaella Zanardi
    San Raffaele Hospital Department of Psychiatry, Vita Salute University, Milan, Italy
    Psychiatry Clin Neurosci 62:627-37. 2008
    ..The aim was to bridge gaps between the research evidence and clinical decisions, and reach an agreement on several key points of chronobiological and brain stimulation techniques, as well as on relevant objectives for future research...
  5. ncbi Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression
    Raffaella Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, Milan 20127, Italy
    Eur Neuropsychopharmacol 17:651-7. 2007
    ..Our sample has not the power to control for the possible influence of different medications on these results...
  6. ncbi Comparison of response to fluvoxamine in nondemented elderly compared to younger patients affected by major depression
    Raffaella Zanardi
    Department of Psychiatry San Raffaele Institute, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychopharmacol 23:535-9. 2003
    ..0006). This difference between the 2 age groups was evident since the 2nd week of treatment, and it appeared to be independent of other clinical variables...
  7. ncbi Response to SSRIs and role of the hormonal therapy in post-menopausal depression
    R Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele Hospital, Via Stamira d Ancona 20, Milan 20127, Italy
    Eur Neuropsychopharmacol 17:400-5. 2007
    ..001) in the group without HT. In conclusion, HT appeared to improve the antidepressant response to SSRIs. Furthermore, in post-menopausal women, LH basal levels may be taken into account as possible predictor of response...
  8. ncbi Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: a positron emission tomography scan study
    R Zanardi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychopharmacol 21:53-8. 2001
    ..016). These data suggest that clinical improvement in patients treated with paroxetine is associated with an increase in the density of 5-HT2A receptors in the frontal cortex...
  9. ncbi Faster onset of action of fluvoxamine in combination with pindolol in the treatment of delusional depression: a controlled study
    R Zanardi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychopharmacol 18:441-6. 1998
    ..A rapid clinical response in such patients is of relevance in clinical practice as well as in economic fields, given the direct and indirect costs of depression...
  10. ncbi Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression
    R Zanardi
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Prinetti, Milan 29 20127, Italy
    Biol Psychiatry 50:323-30. 2001
    ..The aim of the present study was to test this finding in a sample of major and bipolar depressives, with or without psychotic features...
  11. ncbi Two-year maintenance treatment with citalopram, 20 mg, in unipolar subjects with high recurrence rate
    L Franchini
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychiatry 60:861-5. 1999
    ..The authors tested the efficacy of citalopram, 40 mg/day, in relapse prevention over a 4-month period and citalopram, 20 mg/day, in recurrence prevention over a 24-month period...
  12. ncbi Patterns of symptom improvement during antidepressant treatment of delusional depression
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Milan, Italy
    Psychiatry Res 94:185-90. 2000
    ..Our data indicate that there is a simultaneous decrease in depressive symptoms during antidepressant treatment of delusional depressives...
  13. ncbi No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors
    A Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 104:195-203. 2001
    ..The investigated DRD2 and DRD4 gene variants therefore do not seem to play a major role in the antidepressant activity of SSRIs, at least in the present sample...
  14. ncbi Tryptophan hydroxylase gene associated with paroxetine antidepressant activity
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Stamira D Ancona 20 20127 Milan, Italy
    Eur Neuropsychopharmacol 11:375-80. 2001
    ..TPH gene variants are therefore a possible modulator of paroxetine antidepressant activity...
  15. ncbi Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Mol Psychiatry 6:586-92. 2001
    ....
  16. ncbi Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity
    Cristina Cusin
    Department of Psychiatry, Vita Salute University, Raffaele del Monte Tabor, Milan, Italy
    Int J Neuropsychopharmacol 5:27-35. 2002
    ..The investigated MAOA and 5-HT-2A gene variants, therefore, do not seem to play a major role in SSRI antidepressant activity...
  17. ncbi A symptom-specific analysis of the effect of high-frequency left or low-frequency right transcranial magnetic stimulation over the dorsolateral prefrontal cortex in major depression
    D Rossini
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Neuropsychobiology 62:91-7. 2010
    ....
  18. ncbi Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder
    J Perez
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    Arch Gen Psychiatry 56:248-53. 1999
    ....
  19. ncbi Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder
    J Perez
    Istituto Scientifico HSR, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Psychiatr Res 34:99-104. 2000
    ..Taken together the results of the present study further support that downstream components of the cAMP signal cascade could be involved in the pathophysiology of bipolar disorders...
  20. ncbi Protein kinase A and Rap1 levels in platelets of untreated patients with major depression
    J Perez
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Via Stamira d Ancona 20, 20127 Milan, Italy
    Mol Psychiatry 6:44-9. 2001
    ..These findings may provide new insight about the relationship between components of cAMP signaling and affective disorders...
  21. ncbi Four-year follow-up study of sertraline and fluvoxamine in long-term treatment of unipolar subjects with high recurrence rate
    L Franchini
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Via Prinetti 29, 20127, Milan, Italy
    J Affect Disord 58:233-6. 2000
    ..During the fourth year no patients showed new episodes of illness...
  22. ncbi Will a second prophylactic treatment with a higher dosage of the same antidepressant either prevent or delay new depressive episodes?
    L Franchini
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Via Luigi Prinetti, 29, 20127, Milan, Italy
    Psychiatry Res 96:81-5. 2000
    ..Moreover, patients with a longer duration of euthymia during a first maintenance period are less likely to have a new episode of depression...
  23. ncbi Abnormalities of cAMP signaling in affective disorders: implication for pathophysiology and treatment
    J Perez
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    Bipolar Disord 2:27-36. 2000
    ..During the last decade, much attention has been given to the role of signal transduction pathways in affective disorders. This review describes the possible role of the cAMP signaling in such disorders...
  24. ncbi Worsening of delusional depression after sleep deprivation: case reports
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    J Psychiatr Res 33:69-72. 1999
    ....
  25. ncbi Antidepressant response in the elderly
    Laura Mandelli
    Department of Psychiatry, University of Bologna, Bologna, Italy
    Psychiatry Res 152:37-44. 2007
    ..Minor health problems increase the severity of depression, but they do not interfere crucially with the efficacy of antidepressant treatment. Finally, late-onset depression is associated with a positive outcome...
  26. ncbi Early onset of lithium prophylaxis as a predictor of good long-term outcome
    L Franchini
    Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, Via Luigi Prinetti, 29, 20127 Milan, Italy
    Eur Arch Psychiatry Clin Neurosci 249:227-30. 1999
    ..Results indicated that beginning lithium therapy within the first ten years of illness predicts better preventive outcomes than beginning prophylaxis later, both in major depression, recurrent and bipolar patients...
  27. ncbi Serotonin transporter promoter genotype and illness recurrence in mood disorders
    Enrico Smeraldi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University Vita-Salute, Via Prinetti 29, 20127, Milan, Italy
    Eur Neuropsychopharmacol 12:73-5. 2002
    ..Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness...
  28. ncbi Relapse during a 6-month continuation treatment with fluvoxamine in an Italian population: the role of clinical, psychosocial and genetic variables
    Danilo Dotoli
    Department of Neuropsychiatric Sciences, School of Medicine, , Istituto Scientifico H San Raffaele-Turro, Via Stamira d'Ancona 20, 20127 Milan, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 30:442-8. 2006
    ..These patients could need a different psychopharmacological strategies and peculiar psychological intervention...
  29. ncbi cAMP signaling pathway in depressed patients with psychotic features
    J Perez
    Istituto Scientifico HSR, Department of Neuropsychiatry, School of Medicine, University Vita Salute, Milan, Italy
    Mol Psychiatry 7:208-12. 2002
    ..These findings support the idea that besides nonpsychotic depression, abnormalities of PKA could be linked, albeit in a somewhat different way, with psychotic depression...
  30. ncbi Long-term treatment with citalopram in patients with highly recurrent forms of unipolar depression
    L Franchini
    Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Universita Vita e Salute, Via Luigi Prinetti, 29, 20127, Milan, Italy
    Psychiatry Res 105:129-33. 2001
    ..No relapses were observed. At the time of recovery, 32/36 subjects received maintenance treatment with citalopram (40 mg) for an additional 24 months. At the end of the study, 11/32 patients experienced a single new recurrence...
  31. ncbi Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:504-11. 2004
    ..The present study investigated possible genetic association between some polymorphisms possibly involved in antidepressant response and the occurrence of manic or hypo-manic switches during antidepressant treatment...
  32. ncbi 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study
    Cristina Messa
    CNR Institute of Molecular Imaging and Physiology, Istituto Scientifico S Raffaele, University of Milan Bicocca, University of Milan, Milan, Italy
    Psychopharmacology (Berl) 167:72-8. 2003
    ....
  33. ncbi SSRIs antidepressant activity is influenced by G beta 3 variants
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Eur Neuropsychopharmacol 13:117-22. 2003
    ..009) and this effect was independent from analyzed demographic and clinical variables. These results confirm preliminary reports and shed further light on the genetics of the response to antidepressant treatments...
  34. ncbi Does rTMS hasten the response to escitalopram, sertraline, or venlafaxine in patients with major depressive disorder? A double-blind, randomized, sham-controlled trial
    David Rossini
    Department of Psychiatry, School of Medicine, Vita Salute University, San Raffaele Hospital, Via Stamina d Ancona 20, 20127 Milan, Italy
    J Clin Psychiatry 66:1569-75. 2005
    ..We also evaluated if, among the 3 antidepressants administered, one had a better synergy with rTMS...
  35. ncbi Clinical features of antidepressant associated manic and hypomanic switches in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, Milan 20127, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 27:751-7. 2003
    ..Further studies are required to investigate the causal relationships between those factors...
  36. ncbi Transcranial magnetic stimulation in treatment-resistant depressed patients: a double-blind, placebo-controlled trial
    David Rossini
    Department of Psychiatry, School of Medicine, Vita Salute University, San Raffaele Hospital, Via Stamira d Ancona 20, Milan 20127, Italy
    Psychiatry Res 137:1-10. 2005
    ..The results of this double-blind trial showed that rTMS may be a useful and safe adjunctive treatment for drug-resistant depressed patients...
  37. ncbi Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 129:36-40. 2004
    ..Thus, the previous positive association was not fully replicated for TPH. The present independent replication confirms SERTPR variants as a liability factor for antidepressant efficacy while the TPH effect is not unequivocal...
  38. ncbi The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Int J Neuropsychopharmacol 7:453-60. 2004
    ..In conclusion, 5-HT1A variants could influence the antidepressant efficacy in bipolar subjects, even if results must be verified on larger samples...
  39. ncbi Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital, Milan, Italy
    Pharmacogenetics 14:607-13. 2004
    ..We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up...
  40. ncbi The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Centro San Raffaele del Monte Tabor Foundation, Via Stamira d Ancona 20, 20127 Milano, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 29:1074-84. 2005
    ..The present paper reviews the pharmacogenetic studies published to date, focusing the attention on the serotonergic pathway...
  41. ncbi Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, University of Milan School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:36-9. 2005
    ..This, together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders...
  42. ncbi A neural network model for combining clinical predictors of antidepressant response in mood disorders
    Alessandro Serretti
    Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
    J Affect Disord 98:239-45. 2007
    ..The complex interactions modelled through ANN may be eventually applied at the clinical level for the individualized therapy...
  43. ncbi Clinical prediction of antidepressant response in mood disorders: linear multivariate vs. neural network models
    Alessandro Serretti
    Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
    Psychiatry Res 152:223-31. 2007
    ..The complex interactions modelled through ANN may eventually be applied at the clinical level for individualized therapy. However, the accuracy of prediction is still far from satisfactory from a clinical point of view...
  44. ncbi Protein kinase A activity in platelets from patients with bipolar disorder
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Affect Disord 76:249-53. 2003
    ..Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD...
  45. ncbi Improvement of cognitive functioning in mood disorder patients with depressive symptomatic recovery during treatment: an exploratory analysis
    Laura Mandelli
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Psychiatry Clin Neurosci 60:598-604. 2006
    ....