Research Topics
Genomes and Genes | Flavia ValtortaSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Detail Information
Publications
Use of phosphosynapsin I-specific antibodies for image analysis of signal transduction in single nerve terminalsA Menegon
Dept Neuroscience, San Raffaele Scientific Institute, Milan, Italy
J Cell Sci 113:3573-82. 2000....- Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis?Flavia Valtorta
Department of Neuroscience, S Raffaele Scientific Institute and Vita Salute University, Milan, Italy
Bioessays 26:445-53. 2004..In this article, we summarise the main results of the studies on Syp carried out by our and other laboratories, and explain why we believe that Syp plays a major role in SV trafficking... 
Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesiclesMaria Pennuto
Department of Neuroscience, San Raffaele Scientific Institute and Vita Salute University, 20132 Milano, Italy
Mol Biol Cell 14:4909-19. 2003..These data support a role for SypI in directing the correct sorting of VAMP2 in neurons and demonstrate that a direct interaction between the two proteins is required for SypI in order to exert its effect...- Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neuronsDario Bonanomi
Department of Neuroscience, San Raffaele Scientific Institute, Vita Salute University, 20132 Milan, Italy
J Neurosci 25:7299-308. 2005.... - Fluorescence resonance energy transfer detection of synaptophysin I and vesicle-associated membrane protein 2 interactions during exocytosis from single live synapsesMaria Pennuto
Department of Neuroscience, S Raffaele Scientific Institute and Vita Salute University, Milan, Italy
Mol Biol Cell 13:2706-17. 2002.... 
The role of synapsins in neuronal developmentEugenio F Fornasiero
San Raffaele Scientific Institute, Vita Salute University, Via Olgettina 58, 20132, Milan, Italy
Cell Mol Life Sci 67:1383-96. 2010..In this review, we describe the main functional features of the synapsins, in relation to the complex role played by these phosphoproteins in neuronal development...- {alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamicsVítor L Sousa
Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
Mol Biol Cell 20:3725-39. 2009..Actin cytoskeletal disruption induced by the A30P mutant might alter various cellular processes and thereby play a role in the pathogenesis of neurodegeneration... - Phosphorylation by cAMP-dependent protein kinase is essential for synapsin-induced enhancement of neurotransmitter release in invertebrate neuronsFerdinando Fiumara
Department of Neuroscience, Section of Physiology, University of Torino, Corso Raffaello 30, 10125, Italy
J Cell Sci 117:5145-54. 2004.... - Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2Dario Bonanomi
Department of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Mol Pharmacol 67:1901-8. 2005..These early effects of the toxin are followed by severe impairment of SV exo-endocytosis, which might underlie the prevention of neurotransmitter release reported after intoxication by taipoxin... - Normal levels of Rac1 are important for dendritic but not axonal development in hippocampal neuronsSara Gualdoni
DIBIT, San Raffaele Scientific Institute, Milano, Italy
Biol Cell 99:455-64. 2007..There are two distinct Rac proteins expressed in neurons, namely the ubiquitous Rac1 and the neuron-specific Rac3. The specific functions of each of these GTPases during early neuronal development are largely unknown... - Protein sorting in the synaptic vesicle life cycleDario Bonanomi
Department of Neuroscience, San Raffaele Scientific Institute and Vita-Salute University, Milan, Italy
Prog Neurobiol 80:177-217. 2006..As a result of both processes, SVs with heterogeneous molecular make-up, and hence displaying variable competence for exocytosis, may be generated and coexist within the same nerve terminal... - Localization of focal adhesion kinase isoforms in cells of the central nervous systemAndrea Contestabile
Department of Neuroscience, S. Raffaele Scientific Institute and Vita-Salute University, Milano, Italy
Int J Dev Neurosci 21:83-93. 2003.... - The synapsins: multitask modulators of neuronal developmentFlavia Valtorta
San Raffaele Scientific Institute and Vita Salute University, Via Olgettina 58, Milano, Italy
Semin Cell Dev Biol 22:378-86. 2011.... - Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent mannerEugenio F Fornasiero
San Raffaele Scientific Institute and Vita Salute University, I 20132 Milan, Italy
J Neurosci 32:12214-27. 2012.... - Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neuronsAndrea Menegon
Department of Neuroscience, S. Raffaele Scientific Institute and Vita-Salute University, 20132 Milano, Italy
J Neurosci 22:7016-26. 2002..In the presence of a nearly homogeneous subcellular distribution, this highly regionalized regulation of activity may reflect the multifunctional roles of CaMKII in both developing and mature neurons... - Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneuronsGaia Colasante
Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy
J Neurosci 28:10674-86. 2008..These findings contribute elucidating the genetic hierarchy that likely underlies the etiology of a variety of human neurodevelopmental disorders... - Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out miceMarco Cambiaghi
San Raffaele Scientific Institute and Vita Salute University, Milan, Italy
Epilepsy Res 103:153-60. 2013..This aspect might be connected to brain dysfunction often associated to epilepsy in the interictal period... - Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNFPierluigi Valente
Section of Physiology, Department of Experimental Medicine, University of Genoa and National Institute of Neuroscience, 16132 Genova, Italy
J Neurosci 32:5868-79. 2012.... - The synapsin domain E accelerates the exoendocytotic cycle of synaptic vesicles in cerebellar Purkinje cellsAnna Fassio
Center of Neuroscience and Neuroengineering, Department of Experimental Medicine, University of Genoa, Italy
J Cell Sci 119:4257-68. 2006..These effects may increase the sensitivity of postsynaptic neurons to inhibition and thereby contribute to the inhibitory control of network activity... - Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapsesPietro Baldelli
Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, 16163 Genova, Italy
J Neurosci 27:13520-31. 2007..The decreased size of the SV readily releasable pool, coupled with a decreased SV recycling rate and refilling by the SV reserve pool, may contribute to the epileptic phenotype of SynI knock-out mice... - Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesiclesMichela Rigoni
Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy
J Cell Sci 117:3561-70. 2004..These changes closely resemble those occurring at neuromuscular junctions of intoxicated animals and fully qualify these primary neuronal cultures as pertinent models for studying the molecular mode of action of these neurotoxins... - Synapsin phosphorylation by SRC tyrosine kinase enhances SRC activity in synaptic vesiclesFranco Onofri
Department of Experimental Medicine, University of Genova, 16132 Genova, Italy
J Biol Chem 282:15754-67. 2007..We conclude that synapsin is an endogenous substrate and activator of synaptic vesicle-associated c-Src and that regulation of Src activity on synaptic vesicles participates in the regulation of neurotransmitter release by synapsin... - Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin 2/VAMP2Dario Bonanomi
San Raffaele Scientific Institute and Vita Salute University, Via Olgettina 58, 20132 Milan, Italy
Biochem J 404:525-34. 2007.... - Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activityAndrea Menegon
San Raffaele Scientific Institute and Vita-Salute University, 20132 Milan, Italy
J Neurosci 26:11670-81. 2006..These data define a hierarchical crosstalk between cAMP- and CaM-dependent cascades and point to synapsin as a major effector of PKA in the modulation of activity-dependent SV exocytosis... - Synapsin is a novel Rab3 effector protein on small synaptic vesicles. I. Identification and characterization of the synapsin I-Rab3 interactions in vitro and in intact nerve terminalsSilvia Giovedi
Department of Experimental Medicine, Section of Human Physiology, University of Genova, Via Benedetto XV, 16132, Italy
J Biol Chem 279:43760-8. 2004..The data indicate that synapsin I is a novel Rab3 interactor on synaptic vesicles and suggest that the synapsin-Rab3 interaction may participate in the regulation of synaptic vesicle trafficking within the nerve terminals... - Synapsin is a novel Rab3 effector protein on small synaptic vesicles. II. Functional effects of the Rab3A-synapsin I interactionSilvia Giovedi
Department of Experimental Medicine, Section of Human Physiology, University of Genova, Via Benedetto XV, 16132, Italy
J Biol Chem 279:43769-79. 2004..Given the well recognized importance of both synapsins and Rab3A in synaptic vesicles exocytosis, this interaction is likely to play a major role in the modulation of neurotransmitter release...