Alberto Tosetto

Summary

Affiliation: San Bortolo Hospital
Country: Italy

Publications

  1. ncbi request reprint Assessing bleeding in von Willebrand disease with bleeding score
    Alberto Tosetto
    Hematology Department, S Bortolo Hospital, 36100 Vicenza, Italy
    Blood Rev 21:89-97. 2007
  2. doi request reprint Bleeding scores in inherited bleeding disorders: clinical or research tools?
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    Haemophilia 14:415-22. 2008
  3. doi request reprint Bleeders, bleeding rates, and bleeding score
    A Tosetto
    Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 11:142-50. 2013
  4. doi request reprint Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH)
    A Tosetto
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 10:1019-25. 2012
  5. doi request reprint Management of bleeding and of invasive procedures in patients with platelet disorders and/or thrombocytopenia: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)
    A Tosetto
    Clinica Medica III, Universita di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia
    Thromb Res 124:e13-8. 2009
  6. doi request reprint Association or causation: the Janus face of observational research
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 6:555-7. 2008
  7. ncbi request reprint Enoxaparin vs. nadroparin for venous thromboembolism prevention: too close to tell?
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 4:1691-2. 2006
  8. doi request reprint Prospective evaluation of the clinical utility of quantitative bleeding severity assessment in patients referred for hemostatic evaluation
    A Tosetto
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 9:1143-8. 2011
  9. doi request reprint The impact of bleeding history, von Willebrand factor and PFA-100(®) on the diagnosis of type 1 von Willebrand disease: results from the European study MCMDM-1VWD
    Giancarlo Castaman
    Department of Haematology, San Bortolo Hospital, Vicenza, Italy
    Br J Haematol 151:245-51. 2010
  10. ncbi request reprint Intraindividual consistency of the activated protein C resistance phenotype
    Alberto Tosetto
    Hemophilia and Thrombosis Centre, Department of Haematology, S Bortolo Hospital, Vicenza, Italy
    Br J Haematol 126:405-9. 2004

Detail Information

Publications42

  1. ncbi request reprint Assessing bleeding in von Willebrand disease with bleeding score
    Alberto Tosetto
    Hematology Department, S Bortolo Hospital, 36100 Vicenza, Italy
    Blood Rev 21:89-97. 2007
    ..Therefore, BS represent a promising clinical tool for the analysis of bleeding in VWD, although further validation is warranted before an extensive use in clinical practice could be purported...
  2. doi request reprint Bleeding scores in inherited bleeding disorders: clinical or research tools?
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    Haemophilia 14:415-22. 2008
    ....
  3. doi request reprint Bleeders, bleeding rates, and bleeding score
    A Tosetto
    Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 11:142-50. 2013
    ....
  4. doi request reprint Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH)
    A Tosetto
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 10:1019-25. 2012
    ..In patients with unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is anchored on estimating the risk of disease recurrence...
  5. doi request reprint Management of bleeding and of invasive procedures in patients with platelet disorders and/or thrombocytopenia: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)
    A Tosetto
    Clinica Medica III, Universita di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia
    Thromb Res 124:e13-8. 2009
    ....
  6. doi request reprint Association or causation: the Janus face of observational research
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 6:555-7. 2008
  7. ncbi request reprint Enoxaparin vs. nadroparin for venous thromboembolism prevention: too close to tell?
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 4:1691-2. 2006
  8. doi request reprint Prospective evaluation of the clinical utility of quantitative bleeding severity assessment in patients referred for hemostatic evaluation
    A Tosetto
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 9:1143-8. 2011
    ..Quantitative bleeding assessment tools (BATs) have been used to describe the severity of the bleeding phenotype in patients with von Willebrand disease...
  9. doi request reprint The impact of bleeding history, von Willebrand factor and PFA-100(®) on the diagnosis of type 1 von Willebrand disease: results from the European study MCMDM-1VWD
    Giancarlo Castaman
    Department of Haematology, San Bortolo Hospital, Vicenza, Italy
    Br J Haematol 151:245-51. 2010
    ....
  10. ncbi request reprint Intraindividual consistency of the activated protein C resistance phenotype
    Alberto Tosetto
    Hemophilia and Thrombosis Centre, Department of Haematology, S Bortolo Hospital, Vicenza, Italy
    Br J Haematol 126:405-9. 2004
    ..4%) were carriers of the G20210A prothrombin allele. APC resistance not due to FV Leiden is a frequent and consistent phenotype in the general population, with a possibly strong genetic influence...
  11. doi request reprint Bleeding tendency and efficacy of anti-haemorrhagic treatments in patients with type 1 von Willebrand disease and increased von Willebrand factor clearance
    Giancarlo Castaman
    Department of Hematology and Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    Thromb Haemost 105:647-54. 2011
    ..In conclusion, similar to patients with type 1 VWD, also in patients with increased VWF clearance desmopressin maintains a major therapeutic role...
  12. ncbi request reprint A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD)
    A Tosetto
    San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 4:766-73. 2006
    ..A quantitative description of bleeding symptoms in type 1 von Willebrand disease (VWD) has never been reported...
  13. doi request reprint How I treat von Willebrand disease
    Francesco Rodeghiero
    Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy
    Blood 114:1158-65. 2009
    ..On the basis of these results and through a series of illustrative examples, the clinician will be able to select the best approach for the optimal management of VWD, according to the patient's characteristics and clinical circumstances...
  14. ncbi request reprint Hemorrhagic symptoms and bleeding risk in obligatory carriers of type 3 von Willebrand disease: an international, multicenter study
    G Castaman
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 4:2164-9. 2006
    ..We undertook an international, multicenter study to describe the clinical picture and to estimate the bleeding risk in a group of obligatory carriers of type 3 von Willebrand disease (VWD)...
  15. doi request reprint Association of plasma fibrinogen, C-reactive protein and G-455>A polymorphism with early atherosclerosis in the VITA Project cohort
    Alberto Tosetto
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    Thromb Haemost 105:329-35. 2011
    ..5 mg/dl. A persistent increase of plasma fibrinogen is associated with an increased risk of early atherosclerosis...
  16. doi request reprint Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD
    Giancarlo Castaman
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    Blood 111:3531-9. 2008
    ..The presence of subtle multimeric abnormalities did not hamper potential clinically useful responses, as in typical type 1 VWD...
  17. ncbi request reprint The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis
    Marco Ruggeri
    S Bortolo Hospital, Vicenza, Italy
    Ann Intern Med 139:470-5. 2003
    ..The clinical relevance of mild erythrocytosis (hematocrit > 0.48 in women or > 0.51 in men) or thrombocytosis (platelet count > 400 x 10(9) cells/L) in asymptomatic persons is uncertain...
  18. ncbi request reprint Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: a retrospective survey
    Marco Ruggeri
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    Blood 111:666-71. 2008
    ..A high proportion of PV and ET surgeries was complicated by vascular occlusion (7.7%) or by a major hemorrhage (7.3%). Prospective investigations analyzing the optimal prophylaxis in these patients are suggested...
  19. doi request reprint Evidence-based diagnosis of type 1 von Willebrand disease: a Bayes theorem approach
    Alberto Tosetto
    Hematology Department, San Bortolo Hospital, Vicenza, Italy
    Blood 111:3998-4003. 2008
    ..0 (false-positive rate less than one-half). Validation of this approach and of its clinical utility is, however, required by analysis in other cohorts of well-characterized type 1 VWD patients...
  20. ncbi request reprint Factor V Leiden mutation carriership and venous thromboembolism in polycythemia vera and essential thrombocythemia
    Marco Ruggeri
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    Am J Hematol 71:1-6. 2002
    ..FV Leiden mutation is a risk factor for VTE before and at time of diagnosis and for VTE recurrences. Screening for FV Leiden may be considered to identify PV and ET patients at higher risk of recurrences...
  21. doi request reprint Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index: a prospective, multicenter GITMO study
    Roberto Raimondi
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    Blood 120:1327-33. 2012
    ..66, 064, and 0.59, respectively). We confirm the clinical utility of the HCT-CI score that could also identify patients at low NRM risk possibly benefiting from an HSCT-based treatment strategy...
  22. ncbi request reprint The factor V HR2 haplotype and the risk of venous thrombosis: a meta-analysis
    Giancarlo Castaman
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    Haematologica 88:1182-9. 2003
    ..The association of FV Leiden and HR2 haplotype seems not to increase significantly the risk of VTE carried by isolated heterozygosity for FV Leiden. However, well-designed clinical studies are needed to clarify this issue definitely...
  23. pmc Pregnancy and delivery in women with von Willebrand's disease and different von Willebrand factor mutations
    Giancarlo Castaman
    Department of Cell Therapy and Hematology, San Bortolo Hospital, I 36100 Vicenza, Italy
    Haematologica 95:963-9. 2010
    ..Pregnancy in von Willebrand's disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty...
  24. doi request reprint Validation of a rapid test (VWF-LIA) for the quantitative determination of von Willebrand factor antigen in type 1 von Willebrand disease diagnosis within the European multicenter study MCMDM-1VWD
    G Castaman
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    Thromb Res 126:227-31. 2010
    ..Accurate measurement of von Willebrand factor (VWF) is a critical requirement for the diagnosis of von Willebrand disease (VWD)...
  25. ncbi request reprint Prevalence and risk factors of non-fatal venous thromboembolism in the active population of the VITA Project
    A Tosetto
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 1:1724-9. 2003
    ..In 30% of VTE cases, at least two easily recognizable risk factors are present. Clinical assessment of risk factors remains the mainstay of VTE prevention...
  26. ncbi request reprint Impact of plasma von Willebrand factor levels in the diagnosis of type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1VWD)
    A Tosetto
    San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 5:715-21. 2007
    ..However, quantitative analysis of the importance of VWF antigen (VWF:Ag) and ristocetin cofactor activity (VWF:RCo) levels in the diagnosis is lacking...
  27. ncbi request reprint Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis
    G Castaman
    Department of Hematology and Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    Thromb Haemost 86:804-8. 2001
    ..01-1.30). In conclusion, in subjects with G20210A mutation APC resistance is significantly increased, correlates with plasma prothrombin level and the carriers with the lowest APC resistance values have an increased risk of VTE...
  28. ncbi request reprint The A20210 allele in the prothrombin gene enhances the risk of venous thrombosis in carriers of inherited protein S deficiency
    G Castaman
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    Blood Coagul Fibrinolysis 11:321-6. 2000
    ..7-5.41; P = 0.1). In conclusion, the presence of the prothrombin mutation seems to increase the risk of VT carriers of protein S deficiency, although additional families are required to fully estimate the magnitude of risk...
  29. doi request reprint Reduced von Willebrand factor survival in von Willebrand disease: pathophysiologic and clinical relevance
    G Castaman
    Department of Hematology and Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 7:71-4. 2009
    ..Recent evidence suggests that liver and spleen macrophages are responsible for VWF clearance through uptake and endocellular degradation, but it is still not known why some VWF mutants are more prone to increased clearance...
  30. ncbi request reprint The discriminant power of bleeding history for the diagnosis of type 1 von Willebrand disease: an international, multicenter study
    F Rodeghiero
    Hematology Department, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 3:2619-26. 2005
    ..The aim of this study was the validation of the criteria defining a significant mucocutaneous-bleeding history in type 1 von Willebrand disease (VWD)...
  31. doi request reprint Relevance of quantitative assessment of bleeding in haemorrhagic disorders
    F Rodeghiero
    Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    Haemophilia 14:68-75. 2008
    ..Finally, Dr James will review the development of quantitative analysis in children, a particularly important and difficult application, but one that needs to be tackled urgently...
  32. ncbi request reprint How to estimate bleeding risk in mild bleeding disorders
    F Rodeghiero
    Department of Hematology and Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 5:157-66. 2007
    ..Innovative approaches, combining into a single probability phenotypic and genetic data, could possibly estimate better the bleeding risk in specific disorders...
  33. ncbi request reprint Association of protein S p.Pro667Pro dimorphism with plasma protein S levels in normal individuals and patients with inherited protein S deficiency
    G Castaman
    Department of Hematology and Hemophilia and Thrombosis Center, S Bortolo Hospital, 36100 Vicenza, Italy
    Thromb Res 120:421-6. 2007
    ..Glu67Ala mutation), compared to the wild type protein S. The genotype in itself was neither a significant risk factor for venous thrombosis nor a risk modifier in patients with known mutations...
  34. doi request reprint Molecular and phenotypic determinants of the response to desmopressin in adult patients with mild hemophilia A
    G Castaman
    Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 7:1824-31. 2009
    ..The relationship of the biologic response to desmopressin with the F8 mutation and physiological characteristics has been poorly investigated in patients with mild hemophilia A...
  35. ncbi request reprint Pseudohomozygosity for activated protein C resistance is a risk factor for venous thrombosis
    G Castaman
    Department of Haematology and the Haemophilia and Thrombosis Centre, San Bortolo Hospital, Vicenza, Italy
    Br J Haematol 106:232-6. 1999
    ..01). Pseudohomozygosity for APC resistance carries a significantly higher risk for venous thromboembolism in comparison to normal subjects, but probably not in comparison to heterozygous FV Leiden carriers...
  36. doi request reprint Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group
    Francesco Rodeghiero
    Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy
    Blood 121:2596-606. 2013
    ..The SMOG system provides a consistent description of the bleeding phenotype in ITP, and the IWG unanimously supports its adoption and validation in future clinical studies...
  37. ncbi request reprint Prolonged overall survival with second on-demand autologous transplant in multiple myeloma
    Francesca Elice
    Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    Am J Hematol 81:426-31. 2006
    ..9% after the first ASCT but no deaths occurred after the second. Our experience suggests that elective up-front single ASCT followed by second ASCT after relapse or progression is a safe and effective global strategy to treat MM patients...
  38. ncbi request reprint Age-adjusted reference limits for carotid intima-media thickness as better indicator of vascular risk: population-based estimates from the VITA project
    A Tosetto
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    J Thromb Haemost 3:1224-30. 2005
    ....
  39. ncbi request reprint Smoking in arterial and venous thrombosis: the missing link?
    Alberto Tosetto
    Am J Hematol 83:92. 2008
  40. ncbi request reprint D-dimer testing to determine the duration of anticoagulation therapy
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Bologna, Italy
    N Engl J Med 355:1780-9. 2006
    ..The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation...
  41. doi request reprint Different cut-off values of quantitative D-dimer methods to predict the risk of venous thromboembolism recurrence: a post-hoc analysis of the PROLONG study
    Cristina Legnani
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    Haematologica 93:900-7. 2008
    ..The objective of this study was to evaluate the possible advantage of using quantitative D-dimer assays...
  42. ncbi request reprint Evaluation of a new turbidimetric assay for von Willebrand factor activity useful in the general screening of von Willebrand disease
    Montse Piñol
    Haematologica 92:712-3. 2007
    ..Samples from healthy donors and previously diagnosed VWD patients were blindly analyzed by this new activity assay and standard VWF:RCo. Results agreed and both assays showed a similar sensitivity for the screening of VWD...