G Sitia

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Platelets promote liver immunopathology contributing to hepatitis B virus-mediated hepatocarcinogenesis
    Giovanni Sitia
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy Electronic address
    Semin Oncol 41:402-5. 2014
  2. pmc Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B
    Giovanni Sitia
    Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 109:E2165-72. 2012
  3. ncbi Evolution of the E2 region of hepatitis C virus in an infant infected by mother-to-infant transmission
    G Sitia
    Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy
    J Med Virol 64:476-81. 2001
  4. pmc Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis
    Giovanni Sitia
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    PLoS Pathog 7:e1002061. 2011
  5. ncbi Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
    Giovanni Sitia
    San Raffaele Scientific Institute, Chromatin Dynamics Unit, Via Olgettina 58, Milan 20132, Italy
    J Leukoc Biol 81:100-7. 2007
  6. ncbi Naive HIV/HCV-coinfected patients have higher intrahepatic pro-inflammatory cytokines than coinfected patients treated with antiretroviral therapy
    Giovanni Sitia
    Infectious Disease Department, San Raffaele Scientific Institute, Milan, Italy
    Antivir Ther 11:385-9. 2006
  7. ncbi Acute self-limiting hepatitis C after possible sexual exposure: sequence analysis of the E-2 region of the infected patient and sexual partner
    G Morsica
    Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy
    Scand J Infect Dis 33:116-20. 2001
  8. ncbi Impact of HAART on liver histology of HIV/HCV coinfected patients
    A De Bona
    Infectious Diseases Department, San Raffaele Scientific Institute IRCCS, Milan, Italy
    J Biol Regul Homeost Agents 17:195-7. 2003
  9. ncbi Mother-to-child transmission of TT virus: sequence analysis of non-coding region of TT virus in infected mother-infant pairs
    S Bagaglio
    Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy
    Arch Virol 147:803-12. 2002
  10. ncbi Liver fibrosis in HIV-positive patients with hepatitis C virus: role of persistently normal alanine aminotransferase levels
    Caterina Uberti-Foppa
    Clinic of Infectious Diseases, Vita Salute University, San Raffaele Scientific Institute, Milan, Italy
    J Acquir Immune Defic Syndr 41:63-7. 2006

Collaborators

Detail Information

Publications21

  1. ncbi Platelets promote liver immunopathology contributing to hepatitis B virus-mediated hepatocarcinogenesis
    Giovanni Sitia
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy Electronic address
    Semin Oncol 41:402-5. 2014
    ....
  2. pmc Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B
    Giovanni Sitia
    Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 109:E2165-72. 2012
    ....
  3. ncbi Evolution of the E2 region of hepatitis C virus in an infant infected by mother-to-infant transmission
    G Sitia
    Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy
    J Med Virol 64:476-81. 2001
    ..Changes in the dominant strain and evolution of the pattern of quasispecies in the infant from the 10th month of age were possibly due to the immune selection of escape mutants...
  4. pmc Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis
    Giovanni Sitia
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    PLoS Pathog 7:e1002061. 2011
    ..Overall, these results indicate that KCs resolve rather than worsen liver immunopathology...
  5. ncbi Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
    Giovanni Sitia
    San Raffaele Scientific Institute, Chromatin Dynamics Unit, Via Olgettina 58, Milan 20132, Italy
    J Leukoc Biol 81:100-7. 2007
    ....
  6. ncbi Naive HIV/HCV-coinfected patients have higher intrahepatic pro-inflammatory cytokines than coinfected patients treated with antiretroviral therapy
    Giovanni Sitia
    Infectious Disease Department, San Raffaele Scientific Institute, Milan, Italy
    Antivir Ther 11:385-9. 2006
    ..Together, these results suggest that HIV infection may exacerbate the immune-mediated inflammatory response in the liver of patients chronically infected with HCV and antiretroviral therapy may prevent this effect...
  7. ncbi Acute self-limiting hepatitis C after possible sexual exposure: sequence analysis of the E-2 region of the infected patient and sexual partner
    G Morsica
    Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy
    Scand J Infect Dis 33:116-20. 2001
    ..Our findings suggest that the infection was transmitted to the patient from her sexual partner. The resolution of acute hepatitis C in this case was probably related to the host rather than to intrinsic characteristics of the HCV genome...
  8. ncbi Impact of HAART on liver histology of HIV/HCV coinfected patients
    A De Bona
    Infectious Diseases Department, San Raffaele Scientific Institute IRCCS, Milan, Italy
    J Biol Regul Homeost Agents 17:195-7. 2003
    ..No significant difference between grading and staging was evidenced either in PI treated subjects versus patients on ART without PI...
  9. ncbi Mother-to-child transmission of TT virus: sequence analysis of non-coding region of TT virus in infected mother-infant pairs
    S Bagaglio
    Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy
    Arch Virol 147:803-12. 2002
    ..These findings suggest that both in utero and perinatal transmission of TT virus may occur, and that the strain detected in the infants was not invariably dominant in the mothers at delivery...
  10. ncbi Liver fibrosis in HIV-positive patients with hepatitis C virus: role of persistently normal alanine aminotransferase levels
    Caterina Uberti-Foppa
    Clinic of Infectious Diseases, Vita Salute University, San Raffaele Scientific Institute, Milan, Italy
    J Acquir Immune Defic Syndr 41:63-7. 2006
    ....
  11. pmc Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes
    Giovanni Sitia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:13717-22. 2002
    ..The notion that depletion of neutrophils is associated with maintenance of antiviral effects but diminished tissue damage may be significant for the development of immunotherapeutic approaches for the treatment of chronic HBV infection...
  12. doi Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
    Michele De Palma
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, 20132 Milano, Italy
    Cancer Cell 14:299-311. 2008
    ..These results illustrate the therapeutic potential of gene- and cell-based IFN-alpha delivery and should allow the development of IFN treatments that more effectively treat cancer...
  13. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    ....
  14. pmc Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Clin Vaccine Immunol 14:1532-5. 2007
    ....
  15. pmc A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
    Stanimir Ivanov
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Blood 110:1970-81. 2007
    ..However, lack of intracellular TLR9-associated HMGB1 can be compensated by extracellular HMGB1. Thus, the DNA-binding protein HMGB1 shuttles in and out of immune cells and regulates inflammatory responses to CpG-DNA...
  16. ncbi In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance
    Brian D Brown
    San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Blood 109:2797-805. 2007
    ....
  17. ncbi [Innate immunity restoration in patients with HIV/AIDS infection associated with antiretroviral therapy]
    Alejandro Afani
    Hospital Clinico, Universidad de Chile, Santiago, Chile
    Rev Med Chil 134:689-96. 2006
    ..CD4+ T lymphocyte count is the immunological measurement commonly used for the follow up of HIV/AIDS patients...
  18. pmc MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
    Giovanni Sitia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 113:1158-67. 2004
    ....
  19. pmc Platelets mediate cytotoxic T lymphocyte-induced liver damage
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 11:1167-9. 2005
    ..Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function...
  20. pmc HBV pathogenesis in animal models: recent advances on the role of platelets
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Hepatol 46:719-26. 2007
    ....
  21. ncbi Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients
    Sara Trifari
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    J Immunol 177:7451-61. 2006
    ..Together, our data indicate that WASP regulates the transcriptional activation of T cells and is required specifically for Th1 cytokine production...