Alessandro Serretti

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Neuropsychobiology 53:9-16. 2006
  2. pmc Metabolic risk factor profile associated with use of second generation antipsychotics: a cross sectional study in a Community Mental Health Centre
    Ilaria Tarricone
    Institute of Psychiatry, Bologna University, Viale C, Pepoli 5, 40123 Bologna, Italy
    BMC Psychiatry 6:11. 2006
  3. ncbi Pooling pharmacogenetic studies on the serotonin transporter: a mega-analysis
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 145:61-5. 2006
  4. ncbi Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 129:36-40. 2004
  5. ncbi Depressive syndrome in major psychoses: a study on 1351 subjects
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Psychiatry Res 127:85-99. 2004
  6. ncbi Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:504-11. 2004
  7. ncbi Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders
    A Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milano, Italy
    Pharmacogenomics J 4:267-73. 2004
  8. ncbi From molecular biology to pharmacogenetics: a review of the literature on antidepressant treatment and suggestions of possible candidate genes
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:490-503. 2004
  9. ncbi The 5-HT2C receptor as a target for mood disorders
    Alessandro Serretti
    Vita Salute University, Department of Psychiatry, San Raffaele Hospital, Milano, Italy
    Expert Opin Ther Targets 8:15-23. 2004
  10. ncbi New antipsychotics and schizophrenia: a review on efficacy and side effects
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Curr Med Chem 11:343-58. 2004

Detail Information

Publications103 found, 100 shown here

  1. ncbi Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Neuropsychobiology 53:9-16. 2006
    ....
  2. pmc Metabolic risk factor profile associated with use of second generation antipsychotics: a cross sectional study in a Community Mental Health Centre
    Ilaria Tarricone
    Institute of Psychiatry, Bologna University, Viale C, Pepoli 5, 40123 Bologna, Italy
    BMC Psychiatry 6:11. 2006
    ..This cross sectional study aimed to evaluate the metabolic risk factor profile associated with use of SGAs in comparison with non -treated control patients...
  3. ncbi Pooling pharmacogenetic studies on the serotonin transporter: a mega-analysis
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 145:61-5. 2006
    ..This result supports the involvement of the SERTPR gene in response to antidepressant treatments...
  4. ncbi Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 129:36-40. 2004
    ..Thus, the previous positive association was not fully replicated for TPH. The present independent replication confirms SERTPR variants as a liability factor for antidepressant efficacy while the TPH effect is not unequivocal...
  5. ncbi Depressive syndrome in major psychoses: a study on 1351 subjects
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Psychiatry Res 127:85-99. 2004
    ..We identified some symptoms that are common across all major psychoses and symptoms that are more specific to each group...
  6. ncbi Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:504-11. 2004
    ..The present study investigated possible genetic association between some polymorphisms possibly involved in antidepressant response and the occurrence of manic or hypo-manic switches during antidepressant treatment...
  7. ncbi Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders
    A Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milano, Italy
    Pharmacogenomics J 4:267-73. 2004
    ..Further studies on independent and large samples are required to determine the reliability and direction of the possible association between SERTPR variants and lithium outcome...
  8. ncbi From molecular biology to pharmacogenetics: a review of the literature on antidepressant treatment and suggestions of possible candidate genes
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:490-503. 2004
    ....
  9. ncbi The 5-HT2C receptor as a target for mood disorders
    Alessandro Serretti
    Vita Salute University, Department of Psychiatry, San Raffaele Hospital, Milano, Italy
    Expert Opin Ther Targets 8:15-23. 2004
    ..This paper reviews some of the studies on this 5-HT receptor subtype, focusing on its possible importance as a target for mood disorder therapy...
  10. ncbi New antipsychotics and schizophrenia: a review on efficacy and side effects
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Curr Med Chem 11:343-58. 2004
    ....
  11. ncbi Clinical features of antidepressant associated manic and hypomanic switches in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, Milan 20127, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 27:751-7. 2003
    ..Further studies are required to investigate the causal relationships between those factors...
  12. ncbi Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 121:35-8. 2003
    ..Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP...
  13. ncbi Predicting response to lithium in mood disorders: role of genetic polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Pharmacogenomics 3:17-30. 2003
    ....
  14. ncbi DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
    Neurosci Lett 368:269-73. 2004
    ..However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy...
  15. ncbi The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Int J Neuropsychopharmacol 7:453-60. 2004
    ..In conclusion, 5-HT1A variants could influence the antidepressant efficacy in bipolar subjects, even if results must be verified on larger samples...
  16. ncbi Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital, Milan, Italy
    Pharmacogenetics 14:607-13. 2004
    ..We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up...
  17. pmc Influence of postpartum onset on the course of mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    BMC Psychiatry 6:4. 2006
    ..To ascertain the impact of postpartum onset (PPO) on the subsequent time course of mood disorders...
  18. ncbi Genes involved in Alzheimer's disease, a survey of possible candidates
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University School of Medicine, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    J Alzheimers Dis 7:331-53. 2005
    ..The aim of this review is to explore genetics of AD...
  19. ncbi Components of self-esteem in affective patients and non-psychiatric controls
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Via Stamira d Ancona 20, 20127 Milano, Italy
    J Affect Disord 88:93-8. 2005
    ..8, p<0.01; SD: F=0.05, p=0.9). These findings suggest that self-esteem deficit in affective disorders might involve specific components. Implications for research and clinical practice are discussed...
  20. ncbi Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, University of Milan School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:36-9. 2005
    ..This, together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders...
  21. ncbi The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Centro San Raffaele del Monte Tabor Foundation, Via Stamira d Ancona 20, 20127 Milano, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 29:1074-84. 2005
    ..The present paper reviews the pharmacogenetic studies published to date, focusing the attention on the serotonergic pathway...
  22. ncbi Pharmacogenetics in the treatment of depression: pharmacodynamic studies
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital, Milan Italy
    Pharmacogenet Genomics 15:61-7. 2005
    ..Here, a brief overview is provided on the various pharmacogenetic studies published to date that analyse the commonest treatments for depression: antidepressants, sleep deprivation and lithium salts...
  23. ncbi Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, San Raffaele Institute, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 134:191-4. 2005
    ..However, we observed how the s/s variant, commonly associated with detrimental effects, could be beneficial in specific areas of social adjustment...
  24. ncbi Profiles of "manic" symptoms in bipolar I, bipolar II and major depressive disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Affect Disord 84:159-66. 2005
    ....
  25. pmc Neural network analysis in pharmacogenetics of mood disorders
    Alessandro Serretti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Milano, Italy
    BMC Med Genet 5:27. 2004
    ..However the combined analysis of multiple gene polymorphisms and clinical variables requires the use of non linear methods...
  26. ncbi Clinical and demographic features of mood disorder subtypes
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Luigi Prinetti 29, Milan, Italy
    Psychiatry Res 112:195-210. 2002
    ..This finding may help in the search for the biological basis of mood disorders...
  27. ncbi Outcome of affective psychosis
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Depress Anxiety 10:50-4. 1999
    ..Stratification by gender or polarity was precluded by the small sample size. These results furnish evidence of poor inter-episode function in patients with delusional mood disorder...
  28. ncbi Pharmacogenetics in affective disorders
    Alessandro Serretti
    Department of Psychiatry, Instituto Scientifico H San Raffaele, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Via Stamira d Ancona 20, 20127, Milan, Italy
    Eur J Pharmacol 438:117-28. 2002
    ..In conclusion, both acute and long-term treatments appear to be, at least to some extent, under genetic influence and preliminary data have identified possible liability genes...
  29. ncbi No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico H San Raffaele, University of Milan School of Medicine, Italy
    Am J Med Genet 88:481-5. 1999
    ..No interaction was observed on the other symptom factors. The serotonin transporter gene does not, therefore, interact with DRD4 in determining the symptomatology of major psychoses...
  30. ncbi No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors
    A Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 104:195-203. 2001
    ..The investigated DRD2 and DRD4 gene variants therefore do not seem to play a major role in the antidepressant activity of SSRIs, at least in the present sample...
  31. ncbi Major psychoses symptomatology: factor analysis of 2241 psychotic subjects
    A Serretti
    Dept of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, School of Medicine, Milano, Italy
    Eur Arch Psychiatry Clin Neurosci 251:193-8. 2001
    ..When scored by the OPCRIT checklist, major psychoses symptomatology is composed of excitement, depressive, delusion and disorganization symptoms...
  32. ncbi Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Mol Psychiatry 6:586-92. 2001
    ....
  33. ncbi DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: a study on 2,011 affected subjects
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet 105:283-90. 2001
    ..This analysis in an enlarged sample suggests that DRD4*Long alleles exert a small but significant influence on the delusional symptomatology in subjects affected by major psychoses...
  34. ncbi Dopamine receptor D4 gene is not associated with major psychoses
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico San Raffaele, University of Milan School of Medicine, Italy
    Am J Med Genet 88:486-91. 1999
    ..Our results exclude that coding variants of the DRD4 exon 1 and 3 may play a major role in conferring susceptibility to major psychoses; moreover, we could not replicate the association of DRD4 exon 1 variant with delusional disorder...
  35. ncbi Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Milan, Italy
    Am J Med Genet 96:161-6. 2000
    ..Genetic variation at the 5HT1A and 5HT2C receptor genes does not, therefore, play a major role in the pathogenesis of mood disorders symptomatology. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:161-166, 2000...
  36. ncbi Melancholic features and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Depress Anxiety 11:73-9. 2000
    ..Our preliminary findings suggest that melancholic features may be associated with favorable lithium prophylactic outcome in mood disorders...
  37. ncbi Tryptophan hydroxylase gene and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    J Psychiatr Res 33:371-7. 1999
    ..TPH variants may be a possible factor influencing the prophylactic efficacy of lithium in mood disorders...
  38. ncbi Patterns of symptom improvement during antidepressant treatment of delusional depression
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Milan, Italy
    Psychiatry Res 94:185-90. 2000
    ..Our data indicate that there is a simultaneous decrease in depressive symptoms during antidepressant treatment of delusional depressives...
  39. ncbi Linkage of mood disorders with D2, D3 and TH genes: a multicenter study
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Via Luigi Prinetti 29, 20127, Milan, Italy
    J Affect Disord 58:51-61. 2000
    ..We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH)...
  40. ncbi Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    J Psychiatr Res 34:89-98. 2000
    ..No 5-HT1A gene variant was identified. 5-HT2A and 2C variants are not, therefore, associated with lithium prophylactic efficacy in mood disorders...
  41. ncbi Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Psychiatry Res 87:7-19. 1999
    ..DRD2, DRD4 and GABRA1 variants therefore do not appear to be associated with the outcome of lithium prophylaxis in mood disorders...
  42. ncbi Serotonin-2A receptor gene is not associated with symptomatology of schizophrenia
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Am J Med Genet 96:84-7. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:84-87, 2000...
  43. ncbi Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Milano, Italy
    Psychiatry Res 89:107-14. 1999
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. DRD4 exon 3 variants are not a main factor influencing TSD outcome in bipolar disorder...
  44. ncbi Dopamine D3 receptor gene not associated with symptomatology of major psychoses
    A Serretti
    Department of Neuropsychiatric Sciences, Instituto Scientifico H San Raffaele, University of Milan School of Medicine, Italy
    Am J Med Genet 88:476-80. 1999
    ..DRD3 variants were not associated with these symptomatologic factors, and consideration of possible stratification effects, such as sex and psychiatric diagnosis, did not reveal any association either...
  45. ncbi No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Psychiatry Res 86:203-9. 1999
    ..Genetic variation at the 5-HT2A receptor gene does not, therefore, appear to play a major role in the pathogenesis of major mood disorders...
  46. ncbi Delineating psychopathologic clusters within dysthymia: a study of 512 out-patients without major depression
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neurospychiatric Sciences, University of Milan School of Medicine, Italy
    J Affect Disord 56:17-25. 1999
    ..Furthermore, as previous studies have examined these symptoms more in relation to prevalence than to possible symptom aggregation, in the present analyses we address both aspects...
  47. ncbi Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet 114:361-9. 2002
    ..Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in mood disorders...
  48. ncbi Lithium long-term treatment in mood disorders: clinical and genetic predictors
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, San Raffaele Institute, Via Stamira d Ancona 20, 20127 Milan, Italy
    Pharmacogenomics 3:117-29. 2002
    ..A number of other candidate genes and anonymous markers did not yield positive associations. Therefore, even though some positive results have been reported, no unequivocal susceptibility gene for lithium efficacy has been identified...
  49. ncbi Serotonin transporter gene associated with lithium prophylaxis in mood disorders
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Pharmacogenomics J 1:71-7. 2001
    ..5-HTTLPR variants may be a possible influencing factor for the prophylactic efficacy of lithium in mood disorders...
  50. ncbi Serotonin transporter gene not associated with psychotic symptomatology of mood disorders
    A Serretti
    Istituto Scientifico H San Raffaele, Department of Neuroscience, University of Milano School of Medicine, Milan, Italy
    Psychiatry Res 86:59-65. 1999
    ..The serotonin transporter gene does not, therefore, appear to be associated with the symptomatology of mood disorders...
  51. ncbi Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet 114:370-9. 2002
    ..The pathways influenced by those variants are not therefore involved with long-term lithium outcome in our sample...
  52. ncbi Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity
    Cristina Cusin
    Department of Psychiatry, Vita Salute University, Raffaele del Monte Tabor, Milan, Italy
    Int J Neuropsychopharmacol 5:27-35. 2002
    ..The investigated MAOA and 5-HT-2A gene variants, therefore, do not seem to play a major role in SSRI antidepressant activity...
  53. ncbi Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita Salute San Raffaele, Milano, Italy
    Biol Psychiatry 54:687-92. 2003
    ..The short-term relapse that follows acute response to TSD has been successfully prevented by combining TSD with light therapy. The mechanism of action of this combined treatment is unknown...
  54. ncbi A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milano, Italy
    Neurosci Lett 368:123-6. 2004
    ....
  55. doi Further evidence supporting the influence of brain-derived neurotrophic factor on the outcome of bipolar depression: independent effect of brain-derived neurotrophic factor and harm avoidance
    Laura Mandelli
    Department of Psychiatry, University of Bologna, Viale C Pepoli 5, Bologna, Italy
    J Psychopharmacol 24:1747-54. 2010
    ..Given that many factors may influence response to pharmacological treatments, studies that consider personality and other individual characteristics are warranted also in pharmacogenetic investigations...
  56. ncbi SSRIs antidepressant activity is influenced by G beta 3 variants
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Eur Neuropsychopharmacol 13:117-22. 2003
    ..009) and this effect was independent from analyzed demographic and clinical variables. These results confirm preliminary reports and shed further light on the genetics of the response to antidepressant treatments...
  57. ncbi Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Psychiatr Genet 13:121-6. 2003
    ..The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach...
  58. ncbi Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 158:132-40. 2008
    ....
  59. ncbi Serotonin transporter gene influences the time course of improvement of "core" depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 149:185-93. 2007
    ....
  60. ncbi A neural network model for combining clinical predictors of antidepressant response in mood disorders
    Alessandro Serretti
    Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
    J Affect Disord 98:239-45. 2007
    ..The complex interactions modelled through ANN may be eventually applied at the clinical level for the individualized therapy...
  61. ncbi Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, San Raffaele Turro, 20127 Milano, Italy
    Neurosci Lett 376:51-5. 2005
    ....
  62. ncbi Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders
    Cristina Cusin
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet 114:380-90. 2002
    ..Our results suggest that MAO-A, COMT, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in mood disorders...
  63. ncbi Role of substance abuse comorbidity and personality on the outcome of depression in bipolar disorder: harm avoidance influences medium-term treatment outcome
    Laura Mandelli
    Department of Psychiatry, University of Bologna, Bologna, Italy
    Psychopathology 45:174-8. 2012
    ..Though several limitations characterize the present study, neurotic personality traits seem to be associated with a slower recovery from depressive symptoms in BD, independently from their initial severity...
  64. ncbi Antidepressant response in the elderly
    Laura Mandelli
    Department of Psychiatry, University of Bologna, Bologna, Italy
    Psychiatry Res 152:37-44. 2007
    ..Minor health problems increase the severity of depression, but they do not interfere crucially with the efficacy of antidepressant treatment. Finally, late-onset depression is associated with a positive outcome...
  65. ncbi Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:631-5. 2007
    ..Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders...
  66. ncbi A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy
    Neurosci Lett 355:37-40. 2004
    ....
  67. ncbi Relapse during a 6-month continuation treatment with fluvoxamine in an Italian population: the role of clinical, psychosocial and genetic variables
    Danilo Dotoli
    Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita Salute, Istituto Scientifico H San Raffaele Turro, Via Stamira d Ancona 20, 20127 Milan, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 30:442-8. 2006
    ..These patients could need a different psychopharmacological strategies and peculiar psychological intervention...
  68. ncbi Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants
    Enrico Smeraldi
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
    Psychiatr Genet 16:153-8. 2006
    ..These results, although very preliminary, can represent a further step toward a better understanding of the molecular genetics of antidepressant response...
  69. doi Clinical features, response to treatment and functional outcome of bipolar disorder patients with and without co-occurring substance use disorder: 1-year follow-up
    Marianna Mazza
    Department of Psychiatry, Bipolar Disorders Unit, Catholic University of Sacred Heart, Rome, Italy
    J Affect Disord 115:27-35. 2009
    ..The purpose of this study was to examine clinical and psychopathological features of BP with and without comorbid SUD in a real-world setting...
  70. ncbi Dimensions of major psychoses: a confirmatory factor analysis of six competing models
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 127:101-9. 2004
    ....
  71. ncbi Rapid cycling mood disorder: clinical and demographic features
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Compr Psychiatry 43:336-43. 2002
    ..Our findings suggest that rapid cycling bipolar disorder is a condition characterized by less severe psychotic and suicidal features, particularly within bipolar I disorder...
  72. ncbi Catechol-O-methyltransferase gene variants in mood disorders in the Italian population
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy
    Psychiatr Genet 16:181-2. 2006
    ....
  73. ncbi How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes
    Paola Artioli
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital Scientific Institute, Milan, Italy
    Eur Neuropsychopharmacol 17:587-94. 2007
    ..These preliminary results could shed further light on the involvement of circadian genes in various aspects of physiological and psychopathological mechanisms of the brain...
  74. ncbi Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, University of Vita Salute San Raffaele, School of Medicine, Milano, Italy
    Am J Med Genet B Neuropsychiatr Genet 123:23-6. 2003
    ..Given the post-hoc nature of the finding, replication in independent samples is necessary to confirm it...
  75. ncbi HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:291-9. 2007
    ..In conclusion, our study does not support the notion that HTR2C and HTR1A gene variants are major contributors to suicide-, anger-, or aggression-related behaviors in our sample...
  76. ncbi Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Universita Vita Salute San Raffaele, School of Medicine, Milan, Italy
    Psychiatry Res 118:241-7. 2003
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. The tested gene variants are not a main factor influencing TSD outcome in bipolar disorder...
  77. ncbi Comparison of response to fluvoxamine in nondemented elderly compared to younger patients affected by major depression
    Raffaella Zanardi
    Department of Psychiatry San Raffaele Institute, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychopharmacol 23:535-9. 2003
    ..0006). This difference between the 2 age groups was evident since the 2nd week of treatment, and it appeared to be independent of other clinical variables...
  78. ncbi Psychometric characteristic of the Italian version of the Temperament and Character Inventory--revised, personality, psychopathology, and attachment styles
    Giovanni Martinotti
    Department of Psychiatry, Catholic University Medical School, 00168 Rome, Italy
    Compr Psychiatry 49:514-22. 2008
    ..Personality features are also confirmed as risk factors for specific psychopathologic domains, impulsivity, anger, and hostility. Furthermore, we found attachment styles of nonclinical subjects correlated with personality features...
  79. ncbi Sertraline versus fluvoxamine in the treatment of elderly patients with major depression: a double-blind, randomized trial
    David Rossini
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    J Clin Psychopharmacol 25:471-5. 2005
    ..Given the lack of literature data regarding fluvoxamine in the treatment of depressed elderly patients, the aim of the present study was to compare its efficacy and tolerability with those of sertraline in a sample of elderly patients...
  80. ncbi Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment
    Enrico Lattuada
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute, Vita Salute University School of Medicine, Milan, Italy
    Int J Neuropsychopharmacol 7:489-93. 2004
    ..017). An association trend was observed between the 'short' variant of DRD4 and TD (p=0.022). We did not observe any significant association for the DRD2 and DRD3 polymorphisms...
  81. ncbi Harm avoidance moderates the influence of serotonin transporter gene variants on treatment outcome in bipolar patients
    Laura Mandelli
    Department of Psychiatry, University of Bologna, Italy
    J Affect Disord 119:205-9. 2009
    ..Given that many factors may influence response to pharmacological treatments, studies that consider personality and other individual characteristics are warranted also in pharmacogenetic investigations...
  82. ncbi Clinical prediction of antidepressant response in mood disorders: linear multivariate vs. neural network models
    Alessandro Serretti
    Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
    Psychiatry Res 152:223-31. 2007
    ..The complex interactions modelled through ANN may eventually be applied at the clinical level for individualized therapy. However, the accuracy of prediction is still far from satisfactory from a clinical point of view...
  83. ncbi Seasonal variations of lithium plasma levels
    Cristina Cusin
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Via Stamira d Ancona 20, 20127, Milan, Italy
    Psychiatry Res 111:35-41. 2002
    ..In conclusion, we observed a significant variation of lithium plasma levels according to seasons. If confirmed, this finding could have both clinical and research implications...
  84. ncbi The XIIth World Congress of Psychiatric Genetics. October 9-13, 2004, Dublin, Ireland
    Cristina Lorenzi
    Vita Salute University, Department of Psychiatry, San Raffaele Institute, via Stamira D Ancona, 20 20127 Milan, Italy
    Pharmacogenomics 6:199-204. 2005
  85. ncbi DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
    Neurosci Lett 440:150-4. 2008
    ..008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline...
  86. ncbi 5-HT2A SNPs and the Temperament and Character Inventory
    Alessandro Serretti
    Institute of Psychiatry University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 31:1275-81. 2007
    ..003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p=0.01) in the Italian sample. We conclude that 5-HT(2A) SNPs may marginally modulate personality traits but further studies are required...
  87. ncbi Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1041-4. 2008
    ..The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression...
  88. doi No association of TPH1 218A/C polymorphism with treatment response and intolerance to SSRIs in Japanese patients with major depression
    Masaki Kato
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Neuropsychobiology 56:167-71. 2007
    ..In the present study, we examined the possible association of the TPH1 218A/C polymorphism with response to SSRIs in a sample of Japanese patients with major depression...
  89. ncbi Estrogen receptor gene 1 variants are not associated with suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 160:1-7. 2008
    ..In conclusion, our study does not support the hypothesis that estrogen receptor alpha gene variants are major contributors to suicide or to anger- or aggression-related behaviors...
  90. ncbi Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes
    Vita Dolzan
    University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Vrazov trg 2, SI 1000 Ljubljana, Slovenia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1562-6. 2008
    ..In the present study, we investigated the effects of the 44 bp insertion/deletion polymorphism in the promoter region of 5-HTT gene (5-HTTLPR) on symptomatology of psychosis and clinical response to antipsychotic drugs...
  91. ncbi No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea, College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Neurosci Res 52:195-9. 2005
    ....
  92. ncbi TNFB polymorphism may be associated with schizophrenia in the Korean population
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, The Catholic University of Korea, St Mary s Hospital, 62 Yoido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Schizophr Res 61:39-45. 2003
    ..Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population...
  93. ncbi Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders
    Jayanti Chotai
    Division of Psychiatry, Department of Clinical Sciences, University of Umea, Umea, Sweden
    Neuropsychobiology 51:3-9. 2005
    ....
  94. ncbi Two new rare variants in the circadian "clock" gene may influence sleep pattern
    Adele Pirovano
    Genet Med 7:455-7. 2005
  95. ncbi Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders
    Isabelle Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 114:177-85. 2002
    ..Our large European sample allowed for replicating of some previous reported positive findings obtained in other study populations...
  96. ncbi Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin
    Bárbara Arias
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Affect Disord 90:251-6. 2006
    ..The COMT gene might be a good candidate for explaining some aspects of the pharmacological response to SSRIs...
  97. ncbi Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study
    Julien Mendlewicz
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, Belgium
    Eur J Hum Genet 12:377-82. 2004
    ..Our negative findings are not attributable to the lack of statistical power, and may contribute to clarify the role of 5-HTTLPR polymorphism in AD...
  98. ncbi Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Neuropsychobiology 47:182-6. 2003
    ..These results suggest that 5-HTTLPR may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population...
  99. ncbi Retrospective analysis of psychomotor agitation, hypomanic symptoms, and suicidal ideation in unipolar depression
    Paolo Olgiati
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Depress Anxiety 23:389-97. 2006
    ....
  100. ncbi Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a multicentric European study
    Pierre Oswald
    University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Eur Neuropsychopharmacol 13:365-8. 2003
    ..Therefore, to exclude the implication of HTR2A in UPAD, this result must be replicated in larger samples and in other populations using the transmission disequilibrium test and different polymorphisms around HTR2A...
  101. ncbi Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms
    Jayanti Chotai
    Division of Psychiatry, Department of Clinical Sciences, University of Umea, 901 85, Umea, Sweden
    Psychiatry Res 119:99-111. 2003
    ....