Davide Seripa

Summary

Affiliation: San Giovanni Rotondo
Country: Italy

Publications

  1. ncbi request reprint The RELN locus in Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo dalla Sofferenza, San Giovanni Rotondo FG, I 71013, Italy
    J Alzheimers Dis 14:335-44. 2008
  2. doi request reprint TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementia
    Davide Seripa
    Gerontology and Geriatrics Research Laboratory, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 31:731-40. 2012
  3. ncbi request reprint The serotonin transporter gene locus in late-life major depressive disorder
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, Institute of Care and Scientific Research Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Am J Geriatr Psychiatry 21:67-77. 2013
  4. doi request reprint Pharmacogenetics in older people: what we know and what we need to know
    Davide Seripa
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Nephrol 25:S38-47. 2012
  5. doi request reprint The genetics of the human APOE polymorphism
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Rejuvenation Res 14:491-500. 2011
  6. doi request reprint Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Neurosci Lett 438:335-9. 2008
  7. doi request reprint Pharmacogenetics of cytochrome P450 (CYP) in the elderly
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Ageing Res Rev 9:457-74. 2010
  8. doi request reprint Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 25:287-92. 2008
  9. doi request reprint Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Pharmacogenet Genomics 21:225-30. 2011
  10. doi request reprint The APOE gene locus in frontotemporal dementia and primary progressive aphasia
    Davide Seripa
    BiolD, Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo
    Arch Neurol 68:622-8. 2011

Collaborators

Detail Information

Publications68

  1. ncbi request reprint The RELN locus in Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo dalla Sofferenza, San Giovanni Rotondo FG, I 71013, Italy
    J Alzheimers Dis 14:335-44. 2008
    ..These findings suggest that RELN gene variants may play a role in the pathogenesis of AD, particularly in females...
  2. doi request reprint TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementia
    Davide Seripa
    Gerontology and Geriatrics Research Laboratory, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 31:731-40. 2012
    ..Although the genetics of PPA and bvFTD needs further investigation, our results suggested the presence of a different genetic background underlying PPA and bvFTD at the 19q13-q13.2 chromosomal region...
  3. ncbi request reprint The serotonin transporter gene locus in late-life major depressive disorder
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, Institute of Care and Scientific Research Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Am J Geriatr Psychiatry 21:67-77. 2013
    ..The aim of this study was to explore the possible involvement of the SLC6A4 locus in patients with late-life MDD by means of a haplotype-tagged approach...
  4. doi request reprint Pharmacogenetics in older people: what we know and what we need to know
    Davide Seripa
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Nephrol 25:S38-47. 2012
    ..The knowledge of what we know and what we need to know is needed to advance the application of pharmacogenetics in clinical practice, in order to introduce personalized treatments for elderly people...
  5. doi request reprint The genetics of the human APOE polymorphism
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Rejuvenation Res 14:491-500. 2011
    ..We also focus on the commonly accepted hypothesis for the evolution of the common APOE gene variants, in which we include the ε3r haplotype, previously not considered...
  6. doi request reprint Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Neurosci Lett 438:335-9. 2008
    ..No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD...
  7. doi request reprint Pharmacogenetics of cytochrome P450 (CYP) in the elderly
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Ageing Res Rev 9:457-74. 2010
    ..The status of what we know and what we need to know is the base for the clinical applications of pharmacogenetics, in which personalized drug treatments constituted the main aim, in particular in patients attending a geriatric ward...
  8. doi request reprint Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 25:287-92. 2008
    ..Glutamate transmits signals via the N-methyl-D-aspartate receptors (NMDARs). Aims: The potential involvement of polymorphisms in the GRIN2B gene, encoding subunit 2B of the NMDA receptor, in the risk for AD was evaluated...
  9. doi request reprint Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Pharmacogenet Genomics 21:225-30. 2011
    ..The aim of this study was to evaluate the effect of 16 functional polymorphisms in the CYP2D6 gene on the clinical response to donepezil treatment in patients with mild-to-moderate AD...
  10. doi request reprint The APOE gene locus in frontotemporal dementia and primary progressive aphasia
    Davide Seripa
    BiolD, Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo
    Arch Neurol 68:622-8. 2011
    ..To investigate the role of the apolipoprotein E (APOE) locus in frontotemporal dementia (FTD) and primary progressive aphasia (PPA)...
  11. ncbi request reprint Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy
    Davide Seripa
    Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy
    J Gerontol A Biol Sci Med Sci 61:918-23. 2006
    ..636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity...
  12. ncbi request reprint Simple and effective determination of apolipoprotein E genotypes by positive/negative polymerase chain reaction products
    Davide Seripa
    Research Department, Pathology of Aging and Oncology Unit, IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, FG, Italy
    Diagn Mol Pathol 15:180-5. 2006
    ..6% for the e3/e4 genotype (n=8). Relative allele frequencies were e2=0.060, e3=0.834, and e4=0.106. We describe a new, simple, unequivocal, and nonexpensive method for the identification of the 6 apoE genotypes...
  13. ncbi request reprint Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo FG, Italy
    Ageing Res Rev 8:214-36. 2009
    ..The second part of this article focused on some recently discovered aspects of the APOE polymorphism and their implications for SAD. An attempt to identify the future directions for non-APOE genetic research in SAD was also discussed...
  14. ncbi request reprint Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism
    D Seripa
    Laboratory of Gene Therapy, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
    Neurology 62:1631-3. 2004
    ..However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD...
  15. ncbi request reprint Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients
    Davide Seripa
    Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
    Neurobiol Aging 26:455-64. 2005
    ....
  16. doi request reprint The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes
    Grazia D'Onofrio
    Geriatrics Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
    Int J Geriatr Psychiatry 26:1062-70. 2011
    ..Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes...
  17. ncbi request reprint Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy dseripa operapadrepio it
    Dement Geriatr Cogn Disord 29:424-31. 2010
    ..Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD)...
  18. pmc Association of apolipoprotein E and angiotensin converting enzyme gene polymorphisms with the multidimensional impairment in older patients
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Rejuvenation Res 12:239-47. 2009
    ..No significant associations between APOE and ACE polymorphisms and 2-year mortality were found. APOE and ACE genes might predispose individuals to health and functional status deterioration in old age, and their effect is additive...
  19. ncbi request reprint Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients
    Davide Seripa
    Laboratory of Molecular Pathology and Gene Therapy, IRCCS H Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo FG, Italy
    Neurobiol Aging 24:933-9. 2003
    ..Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD...
  20. pmc Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis
    Giulia Paroni
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
    Age (Dordr) 34:949-68. 2012
    ....
  21. ncbi request reprint Effectiveness of a high-throughput genetic analysis in the identification of responders/non-responders to CYP2D6-metabolized drugs
    Maria Savino
    Laboratory of Clinical Chemistry, Department of Clinical Pathology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Clin Lab 57:887-93. 2011
    ..Aim of this study is the high-throughput analysis of the CYP2D6 polymorphisms to evaluate its effectiveness in the identification of patient responders/non-responders to CYP2D6-metabolized drugs...
  22. ncbi request reprint Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms
    Alberto Pilotto
    Geriatric Unit, Department of Medical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Gastroenterology 133:465-71. 2007
    ..The aim of this study was to evaluate the impact of CYP2C9 polymorphisms on the risk of gastroduodenal bleeding in acute NSAID users...
  23. pmc Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients
    Davide Seripa
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, Foggia, Italy
    Age (Dordr) 33:409-19. 2011
    ..01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients...
  24. pmc The Multidimensional Prognostic Index (MPI), based on a comprehensive geriatric assessment predicts short- and long-term mortality in hospitalized older patients with dementia
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 18:191-9. 2009
    ..In conclusion, the MPI, calculated from information collected in a standardized CGA, accurately stratified hospitalized elderly patients with dementia into groups at varying risk of short- and long-term mortality...
  25. ncbi request reprint Neuropsychiatric symptoms and functional status in Alzheimer's disease and vascular dementia patients
    Grazia D'Onofrio
    Geriatric Unit and Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Curr Alzheimer Res 9:759-71. 2012
    ....
  26. doi request reprint Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer's disease
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Ageing Res Rev 11:87-103. 2012
    ..In fact, identifying predisposing genetic risk factors may allow us to understand the pathophysiological features of neuropsychiatric syndromes or symptoms in AD, so optimizing possible therapeutic options...
  27. doi request reprint Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Foggia, Italy
    Rejuvenation Res 13:645-52. 2010
    ..014,; 95% CI, 2.528-6.382). Our findings supported a role of the GSTO1 rs4925 SNP in the risk of sporadic AD in southern Italy, suggesting that this and other variants of the GSTO1 gene could be implicated in AD pathogenesis...
  28. ncbi request reprint Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia
    Giuseppe Orsitto
    Geriatric Unit, Medical Sciences Department, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 23:327-33. 2007
    ..However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects...
  29. ncbi request reprint Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection
    Paola Parrella
    Laboratory of Oncology, Department of Research, IRCCS Casa Sollievo della Sofferenza, Viale Padre Pio, San Giovanni Rotondo, FG, I 71013, Italy
    Eur J Epidemiol 22:159-62. 2007
    ..No differences between cases (HPV(+)) and controls (HPV(-)) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV(-) groups...
  30. pmc Development and validation of a multidimensional prognostic index for one-year mortality from comprehensive geriatric assessment in hospitalized older patients
    Alberto Pilotto
    Department of Medical Sciences and Gerontology and Geriatrics Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Rejuvenation Res 11:151-61. 2008
    ..751 (95%CI, 0.71-0.80) at 1 year of follow-up. We conclude that this MPI, calculated from information collected in a standardized CGA, accurately stratifies hospitalized elderly patients into groups at varying risk of mortality...
  31. doi request reprint Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Int J Geriatr Psychiatry 27:1218-38. 2012
    ..However, contrasting findings also exist...
  32. pmc Apolipoprotein E-related all-cause mortality in hospitalized elderly patients
    Maria G Matera
    Department of Medical Sciences, Geriatrics Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Age (Dordr) 32:411-20. 2010
    ..56; 95% CI, 0.36-0.88). In this population, APOE allele variants might play a role on cardiovascular disease-related mortality...
  33. doi request reprint Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy
    Immunotherapy 4:213-38. 2012
    ....
  34. ncbi request reprint Anti-β-amyloid immunotherapy for Alzheimer's disease: focus on bapineuzumab
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Curr Alzheimer Res 8:808-17. 2011
    ..The results of four ongoing large Phase III trials on bapineuzumab will tell us if passive anti-Aβ immunization is able to alter the course if this devastating disease...
  35. doi request reprint Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease
    Grazia D'Onofrio
    IRCCS Casa Sollievo della Sofferenza, Geriatric Unit and Gerontology Geriatric Research Laboratory, San Giovanni Rotondo, Foggia, Italy
    Expert Opin Drug Discov 7:19-37. 2012
    ..APP is believed to be involved in the pathophysiological cascade of AD...
  36. pmc Usefulness of the comprehensive geriatric assessment in older patients with upper gastrointestinal bleeding: a two-year follow-up study
    Alberto Pilotto
    Geriatric Unit and Gerontology and Geriatrics Research Laboratories, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dig Dis 25:124-8. 2007
    ..Aim: To evaluate the usefulness of the CGA as a 2-year mortality multidimensional prognostic index (MPI) in older patients hospitalized for upper gastrointestinal bleeding...
  37. doi request reprint Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms
    Francesco Panza
    Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Alzheimers Dis 21:691-724. 2010
    ..In the future, trials could be undertaken to determine whether modifications of these risk factors, including inflammation, could lower risk of developing cognitive decline...
  38. ncbi request reprint Prevalence, clinical features and avoidability of adverse drug reactions as cause of admission to a geriatric unit: a prospective study of 1756 patients
    Marilisa Franceschi
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Drug Saf 31:545-56. 2008
    ..Drug use increases with advancing age, and in older patients it is associated with an increase in adverse drug reactions (ADRs). ADRs are a primary cause of morbidity and mortality worldwide...
  39. doi request reprint [Forkhead-box-O1 locus and metabolic markers in the elderly: an association study]
    Giulia Paroni
    Unidad Geriátrica y Laboratorio de Investigación de Gerontología y Geriatría, Departamento de Ciencias Médicas, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italia
    Rev Esp Geriatr Gerontol 47:254-8. 2012
    ..These parameters are a risk factor for all-cause mortality in the elderly population. The aim of this study was to investigate the relationship between FOXO1 locus and metabolic-nutritional markers...
  40. doi request reprint REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current state
    Francesco Panza
    IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    CNS Neurosci Ther 16:272-84. 2010
    ..This article briefly reviews the profile of γ-secretase inhibitors, compounds that inhibit γ-secretase, the pivotal enzyme that generates Aβ, and that have reached the clinic...
  41. doi request reprint Current epidemiological approaches to the metabolic-cognitive syndrome
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Alzheimers Dis 30:S31-75. 2012
    ....
  42. ncbi request reprint Peripheral antioxidant markers in mild cognitive impairment and its progression to dementia
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 21:1179-83. 2010
    ....
  43. ncbi request reprint Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients
    Alberto Pilotto
    Geriatric Unit, IRCCS, Casa Sollievo della Sofferenza, Viale Cappuccini, 71013, San Giovanni Rotondo FG, Italy
    World J Gastroenterol 13:4467-72. 2007
    ..To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients...
  44. doi request reprint Dietary unsaturated fatty acids and risk of mild cognitive impairment
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 21:867-70. 2010
    ....
  45. ncbi request reprint Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke
    Davide Seripa
    Molecular Pathology and Gene Therapy Unit, IRCCS H Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy
    Cerebrovasc Dis 15:276-81. 2003
    ..Our results implicate the IL-1Ra gene in the susceptibility to ischemic stroke, and suggest that IL-1Ra genotyping may be useful in the identification of patient subgroups for pharmacological intervention in IL-1 production or actions...
  46. ncbi request reprint Clinical features of reflux esophagitis in older people: a study of 840 consecutive patients
    Alberto Pilotto
    Geriatric Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Am Geriatr Soc 54:1537-42. 2006
    ..To compare symptoms and other clinical characteristics of reflux esophagitis in patients of different ages...
  47. pmc Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
    Int J Alzheimers Dis 2011:721457. 2011
    ....
  48. ncbi request reprint Pharmacogenetics in geriatric medicine: challenges and opportunities for clinical practice
    Alberto Pilotto
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Curr Drug Metab 12:621-34. 2011
    ..Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people...
  49. doi request reprint The prevalence of diarrhea and its association with drug use in elderly outpatients: a multicenter study
    Alberto Pilotto
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Am J Gastroenterol 103:2816-23. 2008
    ..To evaluate the prevalence of diarrhea and its association with drug use in elderly outpatients...
  50. ncbi request reprint Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumors
    Paola Parrella
    Laboratory of Gene Therapy and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Clin Cancer Res 10:5349-54. 2004
    ..In an effort to additionally determine the global patterns of CpG island hypermethylation in sporadic breast cancer, we searched for aberrant promoter methylation at 10 gene loci in 54 primary breast cancer and 10 breast benign lesions...
  51. doi request reprint Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer's disease
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Immunotherapy 2:767-82. 2010
    ..The results of four ongoing large Phase III trials on bapineuzumab will provide answers regarding whether passive anti-Aβ immunization is able to alter the course of this devastating disease...
  52. ncbi request reprint Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroads
    Francesco Panza
    Expert Opin Biol Ther 11:679-86. 2011
    ....
  53. ncbi request reprint Peripheral antioxidant markers in mild cognitive impairment and its progression to dementia
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 21:1179-83. 2010
    ....
  54. ncbi request reprint Effects of hypercapnia on peripheral vascular reactivity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
    Angela de Matthaeis
    Division of Internal Medicine and Chronobiology Unit, Foggia, Italy
    Clin Interv Aging 9:871-8. 2014
    ....
  55. ncbi request reprint Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens
    Paola Parrella
    Laboratory of Molecular Pathology and Gene Therapy, IRCCS H Casa Sollievo della Sofferenza, Viale Cappuccini 1, I 71013 San Giovanni Rotondo FG, Italy
    Cancer Lett 190:73-7. 2003
    ..Our results indicate that D310 abnormalities are detectable in cytology specimens from patients with cancer and support the notion that D310 analysis may represent a new molecular tool for cancer detection...
  56. doi request reprint Effectiveness of the frequency rhythmic electrical modulation system for the treatment of chronic and painful venous leg ulcers in older adults
    Andrea Santamato
    Department of Physical Medicine and Rehabilitation OORR Hospital, University of Foggia, Foggia, Italy
    Rejuvenation Res 15:281-7. 2012
    ..Further investigation is needed to determine its reproducibility in larger case series or randomized clinical trials with longer follow-up periods...
  57. doi request reprint Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele
    Claudia Giannattasio
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Dement Geriatr Cogn Disord 25:354-8. 2008
    ..When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men...
  58. doi request reprint Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Neurosci Lett 432:237-42. 2008
    ..Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD...
  59. ncbi request reprint Lipoproteins, vascular-related genetic factors, and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Lipoprotein Metabolism and Atherosclerosis, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Rejuvenation Res 10:441-58. 2007
    ..While further studies are needed to confirm the possible role of apolipoprotein E concentration as putative longevity factor this paper provides an overview of many of the investigated vascular factors with respect to longevity...
  60. ncbi request reprint Undercoding of Alzheimer's disease and related dementias in hospitalized elderly patients in Italy
    Antonio Greco
    Internal Medicine Department, Casa Sallievo della Sofferenza San Giovanni Rotondo, IRCCS, Italy
    Am J Alzheimers Dis Other Demen 20:167-70. 2005
    ..AD and ADRD are undercoded in elderly hospitalized patients. The limits of the ICD9-CM classification system and the influence of reimbursement amounts may influence the coding reports by physicians...
  61. ncbi request reprint Apoe epsilon2-epsilon4 genotype is a possible risk factor for primary progressive aphasia
    Adele Acciarri
    Ann Neurol 59:436-7. 2006
  62. ncbi request reprint Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease
    Elena Mariani
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Neurol Sci 247:187-91. 2006
    ..Our data suggest that the CTSD-T allele of the CTSD-C/T polymorphism is associated with an increased relative risk for late-onset AD and, more interestingly, the combination of CTSD-T with the A2M-G allele seems to increase this risk...
  63. ncbi request reprint Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different ages
    Francesco Panza
    Atherosclerosis 193:455-7. 2007
  64. ncbi request reprint Apolipoprotein E genotypes in mild cognitive impairment subtypes
    Giuseppe Orsitto
    J Am Geriatr Soc 54:1965-6. 2006
  65. ncbi request reprint A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients
    Emanuela Signori
    Laboratory of Molecular Medicine and Biotechnology, University Campus Bio Medico School of Medicine and Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    Genes Chromosomes Cancer 46:470-7. 2007
    ..More important, we were able to characterize all those patients who were negative at the first PCR-based method screening...
  66. ncbi request reprint DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor
    Paola Mazzarelli
    Laboratory of Molecular Medicine and Biotechnology, Università Campus Bio Medico, Via Longoni, 83, Rome 00155, Italy
    World J Gastroenterol 11:6694-700. 2005
    ..To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis...
  67. ncbi request reprint Diet, cholesterol metabolism, and Alzheimer's disease: Apolipoprotein E as a possible link?
    Francesco Panza
    J Am Geriatr Soc 54:1963-5. 2006
  68. ncbi request reprint ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO mice
    Emanuela Signori
    Institute of Neurobiology and Molecular Medicine, CNR ARTOV, 00133 Rome, Italy
    Biochem Biophys Res Commun 361:543-8. 2007
    ..We propose the use of direct i.m. naked gene transfer in newborns to prevent long-term damages arising from hypercholesterolemic conditions...