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Genomes and Genes | Davide SeripaSummaryAffiliation: San Giovanni Rotondo Country: Italy Publications
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Publications
The RELN locus in Alzheimer's diseaseDavide Seripa
Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo dalla Sofferenza, San Giovanni Rotondo FG, I 71013, Italy
J Alzheimers Dis 14:335-44. 2008..These findings suggest that RELN gene variants may play a role in the pathogenesis of AD, particularly in females...
The serotonin transporter gene locus in late-life major depressive disorderDavide Seripa
Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, Institute of Care and Scientific Research Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy Electronic address
Am J Geriatr Psychiatry 21:67-77. 2013..The aim of this study was to explore the possible involvement of the SLC6A4 locus in patients with late-life MDD by means of a haplotype-tagged approach...- Pharmacogenetics in older people: what we know and what we need to knowDavide Seripa
Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
J Nephrol 25:S38-47. 2012..The knowledge of what we know and what we need to know is needed to advance the application of pharmacogenetics in clinical practice, in order to introduce personalized treatments for elderly people... - TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementiaDavide Seripa
Gerontology and Geriatrics Research Laboratory, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Alzheimers Dis 31:731-40. 2012..Although the genetics of PPA and bvFTD needs further investigation, our results suggested the presence of a different genetic background underlying PPA and bvFTD at the 19q13-q13.2 chromosomal region... - Simple and effective determination of apolipoprotein E genotypes by positive/negative polymerase chain reaction productsDavide Seripa
Research Department, Pathology of Aging and Oncology Unit, IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, FG, Italy
Diagn Mol Pathol 15:180-5. 2006..6% for the e3/e4 genotype (n=8). Relative allele frequencies were e2=0.060, e3=0.834, and e4=0.106. We describe a new, simple, unequivocal, and nonexpensive method for the identification of the 6 apoE genotypes... - The genetics of the human APOE polymorphismDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Rejuvenation Res 14:491-500. 2011..We also focus on the commonly accepted hypothesis for the evolution of the common APOE gene variants, in which we include the ε3r haplotype, previously not considered... - The APOE gene locus in frontotemporal dementia and primary progressive aphasiaDavide Seripa
BiolD, Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo
Arch Neurol 68:622-8. 2011..To investigate the role of the apolipoprotein E (APOE) locus in frontotemporal dementia (FTD) and primary progressive aphasia (PPA)... - Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern ItalyDavide Seripa
Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy
J Gerontol A Biol Sci Med Sci 61:918-23. 2006..636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity... - Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's diseaseDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, San Giovanni Rotondo, Italy
Dement Geriatr Cogn Disord 25:287-92. 2008..Glutamate transmits signals via the N-methyl-D-aspartate receptors (NMDARs). Aims: The potential involvement of polymorphisms in the GRIN2B gene, encoding subunit 2B of the NMDA receptor, in the risk for AD was evaluated... - Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's diseaseDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
Neurosci Lett 438:335-9. 2008..No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD... - Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's diseaseDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo FG, Italy
Ageing Res Rev 8:214-36. 2009..The second part of this article focused on some recently discovered aspects of the APOE polymorphism and their implications for SAD. An attempt to identify the future directions for non-APOE genetic research in SAD was also discussed... - Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patientsDavide Seripa
Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
Neurobiol Aging 26:455-64. 2005.... - Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's diseaseDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Pharmacogenet Genomics 21:225-30. 2011..The aim of this study was to evaluate the effect of 16 functional polymorphisms in the CYP2D6 gene on the clinical response to donepezil treatment in patients with mild-to-moderate AD... - Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphismD Seripa
Laboratory of Gene Therapy, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
Neurology 62:1631-3. 2004..However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD... - Pharmacogenetics of cytochrome P450 (CYP) in the elderlyDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
Ageing Res Rev 9:457-74. 2010..The status of what we know and what we need to know is the base for the clinical applications of pharmacogenetics, in which personalized drug treatments constituted the main aim, in particular in patients attending a geriatric ward... - The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromesGrazia D'Onofrio
Geriatrics Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
Int J Geriatr Psychiatry 26:1062-70. 2011..Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes... - Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementiaDavide Seripa
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy dseripa operapadrepio it
Dement Geriatr Cogn Disord 29:424-31. 2010..Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD)... - Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patientsDavide Seripa
Laboratory of Molecular Pathology and Gene Therapy, IRCCS H Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo FG, Italy
Neurobiol Aging 24:933-9. 2003..Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD... 
Association of apolipoprotein E and angiotensin converting enzyme gene polymorphisms with the multidimensional impairment in older patientsAlberto Pilotto
Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Rejuvenation Res 12:239-47. 2009..No significant associations between APOE and ACE polymorphisms and 2-year mortality were found. APOE and ACE genes might predispose individuals to health and functional status deterioration in old age, and their effect is additive...- Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysisGiulia Paroni
Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
Age (Dordr) 34:949-68. 2012.... - Effectiveness of a high-throughput genetic analysis in the identification of responders/non-responders to CYP2D6-metabolized drugsMaria Savino
Laboratory of Clinical Chemistry, Department of Clinical Pathology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Clin Lab 57:887-93. 2011..Aim of this study is the high-throughput analysis of the CYP2D6 polymorphisms to evaluate its effectiveness in the identification of patient responders/non-responders to CYP2D6-metabolized drugs... - Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphismsAlberto Pilotto
Geriatric Unit, Department of Medical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Gastroenterology 133:465-71. 2007..The aim of this study was to evaluate the impact of CYP2C9 polymorphisms on the risk of gastroduodenal bleeding in acute NSAID users... - Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patientsDavide Seripa
Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, Foggia, Italy
Age (Dordr) 33:409-19. 2011..01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients... - The Multidimensional Prognostic Index (MPI), based on a comprehensive geriatric assessment predicts short- and long-term mortality in hospitalized older patients with dementiaAlberto Pilotto
Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Alzheimers Dis 18:191-9. 2009..In conclusion, the MPI, calculated from information collected in a standardized CGA, accurately stratified hospitalized elderly patients with dementia into groups at varying risk of short- and long-term mortality... - Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer's diseaseFrancesco Panza
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
Ageing Res Rev 11:87-103. 2012..In fact, identifying predisposing genetic risk factors may allow us to understand the pathophysiological features of neuropsychiatric syndromes or symptoms in AD, so optimizing possible therapeutic options... - Neuropsychiatric symptoms and functional status in Alzheimer's disease and vascular dementia patientsGrazia D'Onofrio
Geriatric Unit and Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
Curr Alzheimer Res 9:759-71. 2012.... - Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer diseaseCristiano Capurso
Department of Geriatrics, University of Foggia, Foggia, Italy
Rejuvenation Res 13:645-52. 2010..014,; 95% CI, 2.528-6.382). Our findings supported a role of the GSTO1 rs4925 SNP in the risk of sporadic AD in southern Italy, suggesting that this and other variants of the GSTO1 gene could be implicated in AD pathogenesis... - Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementiaGiuseppe Orsitto
Geriatric Unit, Medical Sciences Department, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Dement Geriatr Cogn Disord 23:327-33. 2007..However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects... - Development and validation of a multidimensional prognostic index for one-year mortality from comprehensive geriatric assessment in hospitalized older patientsAlberto Pilotto
Department of Medical Sciences and Gerontology and Geriatrics Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Rejuvenation Res 11:151-61. 2008..751 (95%CI, 0.71-0.80) at 1 year of follow-up. We conclude that this MPI, calculated from information collected in a standardized CGA, accurately stratifies hospitalized elderly patients into groups at varying risk of mortality... - Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infectionPaola Parrella
Laboratory of Oncology, Department of Research, IRCCS Casa Sollievo della Sofferenza, Viale Padre Pio, San Giovanni Rotondo, FG, I 71013, Italy
Eur J Epidemiol 22:159-62. 2007..No differences between cases (HPV(+)) and controls (HPV(-)) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV(-) groups... - Apolipoprotein E-related all-cause mortality in hospitalized elderly patientsMaria G Matera
Department of Medical Sciences, Geriatrics Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
Age (Dordr) 32:411-20. 2010..56; 95% CI, 0.36-0.88). In this population, APOE allele variants might play a role on cardiovascular disease-related mortality... - Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategiesFrancesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy
Immunotherapy 4:213-38. 2012.... - Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's diseaseGrazia D'Onofrio
IRCCS Casa Sollievo della Sofferenza, Geriatric Unit and Gerontology Geriatric Research Laboratory, San Giovanni Rotondo, Foggia, Italy
Expert Opin Drug Discov 7:19-37. 2012..New APP-selective γ-secretase inhibitors are being developed with the hope of overcoming the previous setbacks... - Anti-β-amyloid immunotherapy for Alzheimer's disease: focus on bapineuzumabFrancesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Curr Alzheimer Res 8:808-17. 2011..The results of four ongoing large Phase III trials on bapineuzumab will tell us if passive anti-Aβ immunization is able to alter the course if this devastating disease... - Usefulness of the comprehensive geriatric assessment in older patients with upper gastrointestinal bleeding: a two-year follow-up studyAlberto Pilotto
Geriatric Unit and Gerontology and Geriatrics Research Laboratories, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Dig Dis 25:124-8. 2007..Aim: To evaluate the usefulness of the CGA as a 2-year mortality multidimensional prognostic index (MPI) in older patients hospitalized for upper gastrointestinal bleeding... - Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanismsFrancesco Panza
Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
J Alzheimers Dis 21:691-724. 2010..In the future, trials could be undertaken to determine whether modifications of these risk factors, including inflammation, could lower risk of developing cognitive decline... - Prevalence, clinical features and avoidability of adverse drug reactions as cause of admission to a geriatric unit: a prospective study of 1756 patientsMarilisa Franceschi
Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Drug Saf 31:545-56. 2008..Drug use increases with advancing age, and in older patients it is associated with an increase in adverse drug reactions (ADRs). ADRs are a primary cause of morbidity and mortality worldwide... - REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current stateFrancesco Panza
IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
CNS Neurosci Ther 16:272-84. 2010..This article briefly reviews the profile of γ-secretase inhibitors, compounds that inhibit γ-secretase, the pivotal enzyme that generates Aβ, and that have reached the clinic... - Current epidemiological approaches to the metabolic-cognitive syndromeFrancesco Panza
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
J Alzheimers Dis 30:S31-75. 2012.... - Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?Francesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Int J Geriatr Psychiatry 27:1218-38. 2012..Copyright © 2012 John Wiley & Sons, Ltd... - Peripheral antioxidant markers in mild cognitive impairment and its progression to dementiaFrancesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Alzheimers Dis 21:1179-83. 2010.... - Dietary unsaturated fatty acids and risk of mild cognitive impairmentFrancesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Alzheimers Dis 21:867-70. 2010.... - Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic strokeDavide Seripa
Molecular Pathology and Gene Therapy Unit, IRCCS H Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy
Cerebrovasc Dis 15:276-81. 2003..Our results implicate the IL-1Ra gene in the susceptibility to ischemic stroke, and suggest that IL-1Ra genotyping may be useful in the identification of patient subgroups for pharmacological intervention in IL-1 production or actions... - Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patientsAlberto Pilotto
Geriatric Unit, IRCCS, Casa Sollievo della Sofferenza, Viale Cappuccini, 71013, San Giovanni Rotondo FG, Italy
World J Gastroenterol 13:4467-72. 2007..To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients... - [Forkhead-box-O1 locus and metabolic markers in the elderly: An association study]Giulia Paroni
Unidad Geriátrica y Laboratorio de Investigación de Gerontología y Geriatría, Departamento de Ciencias Médicas, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italia Electronic address
Rev Esp Geriatr Gerontol 47:254-8. 2012..These parameters are a risk factor for all-cause mortality in the elderly population. The aim of this study was to investigate the relationship between FOXO1 locus and metabolic-nutritional markers... - Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE GeneFrancesco Panza
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
Int J Alzheimers Dis 2011:721457. 2011.... - Pharmacogenetics in geriatric medicine: challenges and opportunities for clinical practiceAlberto Pilotto
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
Curr Drug Metab 12:621-34. 2011..Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people... - Clinical features of reflux esophagitis in older people: a study of 840 consecutive patientsAlberto Pilotto
Geriatric Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Am Geriatr Soc 54:1537-42. 2006..To compare symptoms and other clinical characteristics of reflux esophagitis in patients of different ages... - Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumorsPaola Parrella
Laboratory of Gene Therapy and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Clin Cancer Res 10:5349-54. 2004..In an effort to additionally determine the global patterns of CpG island hypermethylation in sporadic breast cancer, we searched for aberrant promoter methylation at 10 gene loci in 54 primary breast cancer and 10 breast benign lesions... - Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimensPaola Parrella
Laboratory of Molecular Pathology and Gene Therapy, IRCCS H. Casa Sollievo della Sofferenza, Viale Cappuccini 1, I-71013 San Giovanni Rotondo (FG, Italy
Cancer Lett 190:73-7. 2003..Our results indicate that D310 abnormalities are detectable in cytology specimens from patients with cancer and support the notion that D310 analysis may represent a new molecular tool for cancer detection... - Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroadsFrancesco Panza
Expert Opin Biol Ther 11:679-86. 2011.... - Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer's diseaseFrancesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Immunotherapy 2:767-82. 2010..The results of four ongoing large Phase III trials on bapineuzumab will provide answers regarding whether passive anti-Aβ immunization is able to alter the course of this devastating disease... - The prevalence of diarrhea and its association with drug use in elderly outpatients: a multicenter studyAlberto Pilotto
Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
Am J Gastroenterol 103:2816-23. 2008..To evaluate the prevalence of diarrhea and its association with drug use in elderly outpatients... - Peripheral antioxidant markers in mild cognitive impairment and its progression to dementiaFrancesco Panza
Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Alzheimers Dis 21:1179-83. 2010.... - Effectiveness of the frequency rhythmic electrical modulation system for the treatment of chronic and painful venous leg ulcers in older adultsAndrea Santamato
Department of Physical Medicine and Rehabilitation OORR Hospital, University of Foggia, Foggia, Italy
Rejuvenation Res 15:281-7. 2012..Further investigation is needed to determine its reproducibility in larger case series or randomized clinical trials with longer follow-up periods... - Undercoding of Alzheimer's disease and related dementias in hospitalized elderly patients in ItalyAntonio Greco
Internal Medicine Department, Casa Sallievo della Sofferenza San Giovanni Rotondo, IRCCS, Italy
Am J Alzheimers Dis Other Demen 20:167-70. 2005..AD and ADRD are undercoded in elderly hospitalized patients. The limits of the ICD9-CM classification system and the influence of reimbursement amounts may influence the coding reports by physicians... - Apoe epsilon2-epsilon4 genotype is a possible risk factor for primary progressive aphasiaAdele Acciarri
Ann Neurol 59:436-7. 2006 - Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's diseaseElena Mariani
Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
J Neurol Sci 247:187-91. 2006..Our data suggest that the CTSD-T allele of the CTSD-C/T polymorphism is associated with an increased relative risk for late-onset AD and, more interestingly, the combination of CTSD-T with the A2M-G allele seems to increase this risk... - Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different agesFrancesco Panza
Atherosclerosis 193:455-7. 2007 - Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphismsCristiano Capurso
Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
Neurosci Lett 432:237-42. 2008..Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD... - Apolipoprotein E genotypes in mild cognitive impairment subtypesGiuseppe Orsitto
J Am Geriatr Soc 54:1965-6. 2006 - A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patientsEmanuela Signori
Laboratory of Molecular Medicine and Biotechnology, University Campus Bio Medico School of Medicine and Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
Genes Chromosomes Cancer 46:470-7. 2007..More important, we were able to characterize all those patients who were negative at the first PCR-based method screening... - Lipoproteins, vascular-related genetic factors, and human longevityFrancesco Panza
Department of Geriatrics, Center for Lipoprotein Metabolism and Atherosclerosis, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
Rejuvenation Res 10:441-58. 2007..While further studies are needed to confirm the possible role of apolipoprotein E concentration as putative longevity factor this paper provides an overview of many of the investigated vascular factors with respect to longevity... - Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 alleleClaudia Giannattasio
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Dement Geriatr Cogn Disord 25:354-8. 2008..When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men... - DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumorPaola Mazzarelli
Laboratory of Molecular Medicine and Biotechnology, , Via Longoni, 83, Rome 00155, Italy
World J Gastroenterol 11:6694-700. 2005..Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis... - ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO miceEmanuela Signori
Institute of Neurobiology and Molecular Medicine, CNR ARTOV, 00133 Rome, Italy
Biochem Biophys Res Commun 361:543-8. 2007..We propose the use of direct i.m. naked gene transfer in newborns to prevent long-term damages arising from hypercholesterolemic conditions... - Diet, cholesterol metabolism, and Alzheimer's disease: Apolipoprotein E as a possible link?Francesco Panza
J Am Geriatr Soc 54:1963-5. 2006