M G Roncarolo

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint The role of different subsets of T regulatory cells in controlling autoimmunity
    M G Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    Curr Opin Immunol 12:676-83. 2000
  2. ncbi request reprint Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 177:8338-47. 2006
  3. pmc High incidence of severe cyclosporine neurotoxicity in children affected by haemoglobinopaties undergoing myeloablative haematopoietic stem cell transplantation: early diagnosis and prompt intervention ameliorates neurological outcome
    Anna Noè
    Pediatric Immunohaematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy
    Ital J Pediatr 36:14. 2010
  4. pmc Health related quality of life in Middle Eastern children with beta-thalassemia
    Giovanni Caocci
    Centro Trapianti di Midollo Osseo, P, O, R, Binaghi, Via Is Guadazzonis, 3, 09126, Cagliari, Italy
    BMC Blood Disord 12:6. 2012
  5. ncbi request reprint Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 212:28-50. 2006
  6. ncbi request reprint The role of interleukin 10 in the control of autoimmunity
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Autoimmun 20:269-72. 2003
  7. ncbi request reprint Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Nat Rev Immunol 7:585-98. 2007
  8. doi request reprint Is FOXP3 a bona fide marker for human regulatory T cells?
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Eur J Immunol 38:925-7. 2008
  9. ncbi request reprint Type 1 T regulatory cells
    M G Roncarolo
    San Raffaele Telethon Institute of Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 182:68-79. 2001
  10. doi request reprint Clinical tolerance in allogeneic hematopoietic stem cell transplantation
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells, Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 241:145-63. 2011

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The role of different subsets of T regulatory cells in controlling autoimmunity
    M G Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    Curr Opin Immunol 12:676-83. 2000
    ..The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases...
  2. ncbi request reprint Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 177:8338-47. 2006
    ....
  3. pmc High incidence of severe cyclosporine neurotoxicity in children affected by haemoglobinopaties undergoing myeloablative haematopoietic stem cell transplantation: early diagnosis and prompt intervention ameliorates neurological outcome
    Anna Noè
    Pediatric Immunohaematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy
    Ital J Pediatr 36:14. 2010
    ..Neurotoxicity is a recognized complication of cyclosporine A (CSA) treatment. The incidence of severe CSA-related neurological complications following hematopoietic stem cell transplantation (HSCT) is 4-11%...
  4. pmc Health related quality of life in Middle Eastern children with beta-thalassemia
    Giovanni Caocci
    Centro Trapianti di Midollo Osseo, P, O, R, Binaghi, Via Is Guadazzonis, 3, 09126, Cagliari, Italy
    BMC Blood Disord 12:6. 2012
    ..abstract:..
  5. ncbi request reprint Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 212:28-50. 2006
    ....
  6. ncbi request reprint The role of interleukin 10 in the control of autoimmunity
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Autoimmun 20:269-72. 2003
  7. ncbi request reprint Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Nat Rev Immunol 7:585-98. 2007
    ....
  8. doi request reprint Is FOXP3 a bona fide marker for human regulatory T cells?
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Eur J Immunol 38:925-7. 2008
    ..Furthermore, FOXP3-independent mechanisms, mediated by IL-10, contribute to the induction and suppressor functions of Tr1 cells...
  9. ncbi request reprint Type 1 T regulatory cells
    M G Roncarolo
    San Raffaele Telethon Institute of Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 182:68-79. 2001
    ..The use of Tr1 cells to identify novel targets for the development of new therapeutic agents, and as a cellular therapy to modulate peripheral tolerance, can be foreseen...
  10. doi request reprint Clinical tolerance in allogeneic hematopoietic stem cell transplantation
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells, Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 241:145-63. 2011
    ..Furthermore, we summarize different cell therapy approaches with regulatory T cells, designed to facilitate tolerance induction, minimizing pharmaceutical interventions...
  11. ncbi request reprint IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan, Italy
    J Immunol 166:5530-9. 2001
    ....
  12. pmc Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
    J Exp Med 193:1295-302. 2001
    ....
  13. ncbi request reprint Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
    Manuela Battaglia
    San Raffaele Scientific Institute, Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Diabetes 55:1571-80. 2006
    ..Rapamycin plus IL-10 treatment, promoting distinct subsets of Tr cells, may constitute a novel and potent tolerance-inducing protocol for immune-mediated diseases...
  14. ncbi request reprint The role of cytokines (and not only) in inducing and expanding T regulatory type 1 cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Transplantation 77:S16-8. 2004
    ..Whether this combined treatment can also be used in humans is still an open question...
  15. ncbi request reprint Myelin deterioration in Twitcher mice: motor evoked potentials and magnetic resonance imaging as in vivo monitoring tools
    D Dolcetta
    Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milano, Italy
    J Neurosci Res 81:597-604. 2005
    ....
  16. ncbi request reprint Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain
    D Dolcetta
    Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    J Gene Med 8:962-71. 2006
    ..Lentiviral vectors, which are highly efficient to transfer the expression of therapeutic genes in neurons and glial cells, have not been evaluated for direct cerebral therapy in GLD mice...
  17. ncbi request reprint Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  18. ncbi request reprint IL-10-producing T regulatory type 1 cells and oral tolerance
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
    Ann N Y Acad Sci 1029:142-53. 2004
    ..Overall, these data demonstrate that IL-10-producing Tr1 cells play a central role in the induction of oral as well as systemic tolerance...
  19. ncbi request reprint CD4+ regulatory T cells: mechanisms of induction and effector function
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina, 58, Milan I 20132, Italy
    Autoimmun Rev 4:491-6. 2005
    ..A better understanding of the mechanisms underlying the induction and functions of Tr cells in controlling the immune system is critical in view of a future cellular therapy to modulate immune-mediated pathologies...
  20. pmc WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells
    Francesco Marangoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, 20132 Milan, Italy
    J Exp Med 204:369-80. 2007
    ..Thus, WASP appears to play an important role in the activation and suppressor function of nTreg cells, and a dysfunction or incorrect localization of nTreg cells may contribute to the development of autoimmunity in WAS patients...
  21. ncbi request reprint Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients
    Sara Trifari
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    J Immunol 177:7451-61. 2006
    ..Together, our data indicate that WASP regulates the transcriptional activation of T cells and is required specifically for Th1 cytokine production...
  22. ncbi request reprint Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Diabetes 55:40-9. 2006
    ..Thus rapamycin plus IL-10 not only prevented allograft rejection but also induced Tr1 cells that mediated stable antigen-specific, long-term tolerance in vivo...
  23. doi request reprint Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemia
    I Frugnoli
    Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan 20132, Italy
    Bone Marrow Transplant 45:1047-51. 2010
    ..We suggest giving escalating doses of donor T cells to attempt a graft-versus-thalassemia as soon as level 2-3 MC is detected...
  24. doi request reprint Genotypes and haplotypes in the 3' untranslated region of the HLA-G gene and their association with clinical outcome of hematopoietic stem cell transplantation for beta-thalassemia
    F Sizzano
    Unit of Molecular and Functional Immunogenetics, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Tissue Antigens 79:326-32. 2012
    ..07). No association was found with rejection or survival. Taken together, our data show that there is no apparent added value of considering entire 3'UTR HLA-G haplotypes for risk prediction after allogeneic HSCT for beta-thalassemia...
  25. pmc Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells
    Megan K Levings
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Exp Med 196:1335-46. 2002
    ..Together these data indicate that naturally occurring human CD25(+)CD4(+) T cells are distinct from IL-10-producing Tr1 cells...
  26. ncbi request reprint Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Eur J Immunol 32:2237-45. 2002
    ..This growth factor enables a significant in vitro expansion of Tr1 cells facilitating further biological and biochemical characterization of this unique T cell subset...
  27. pmc Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 57:2341-7. 2008
    ..Preclinical murine models have shown that rapamycin enhances nTreg proliferation and regulatory function also in vivo. Objective of this study was to assess whether rapamycin has in vivo effects on human nTregs...
  28. pmc Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome
    M Catucci
    Vita Salute San Raffaele University, Milan, Italy
    Gene Ther 19:1150-8. 2012
    ..These findings show that WAS GT significantly improves DC function, thus adding new evidence of the preclinical efficacy of LV-mediated WAS GT...
  29. ncbi request reprint Utilizing regulatory T cells to control alloreactivity
    E Hauben
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Cytotherapy 7:158-65. 2005
    ..Better understanding of the mechanisms of immune regulation mediated by Tr cells may enable fine-tuning of specific immune responses and pave the way for novel therapeutic approaches...
  30. ncbi request reprint A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors
    J S Dando
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan 20132, Italy
    Hum Gene Ther 12:1979-88. 2001
    ..This novel packaging cell represents a significant advance in HSPC genetic modification technology, combining both a beneficial hematopoietic supportive effect and the gene transfer vector function in a human-based system...
  31. ncbi request reprint Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation
    Loïc Dupré
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, 20132 Milan, Italy
    Hum Gene Ther 17:303-13. 2006
    ..The efficacy of WAS gene transfer into HSCs, using the WAS promoter-containing lentiviral vector, combined with nonlethal irradiation provides a strong rationale for the development of gene therapy for WAS patients...
  32. ncbi request reprint The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells
    Andrea Annoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 110:1788-96. 2007
    ..These data indicate that antitransgene immune response can be modulated by transgene-expressing APCs possibly through deletion of effector T cells...
  33. ncbi request reprint Lentiviral vector-mediated gene transfer in T cells from Wiskott-Aldrich syndrome patients leads to functional correction
    Loïc Dupré
    San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy
    Mol Ther 10:903-15. 2004
    ..The observation that lentiviral vector-mediated gene transfer results in correction of T cell defects in vitro supports their application for gene therapy in WAS patients...
  34. ncbi request reprint The puzzling world of murine T regulatory cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    Microbes Infect 4:559-66. 2002
    ..This review describes the considerable progress made in the recent years in the characterization of the many subsets that constitute the puzzled world of murine T regulatory cells...
  35. pmc An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells
    Silvia Gregori
    San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy
    J Exp Med 201:1293-305. 2005
    ....
  36. pmc Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Department of Regenerative Medicine, Stem Cells, and Gene Therapy, Milan, Italy
    Haematologica 95:2134-43. 2010
    ..Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for regulatory T-cell-based therapies...
  37. ncbi request reprint Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation
    Loïc Dupré
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Immunity 17:157-66. 2002
    ..These results demonstrate that WASP plays a central role in the movements of lipid rafts and identify a potential mechanism underlying the T cell defect affecting WAS patients...
  38. ncbi request reprint Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation
    Silvia Gregori
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Curr Opin Hematol 12:451-6. 2005
    ....
  39. pmc Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant
    Nicola Gagliani
    San Raffaele Diabetes Research Institute HSR DRI, Milan, Italy
    Diabetes 59:433-9. 2010
    ..This study was designed to define the efficacy of Tr1-cell therapy in preclinical models of islet transplant...
  40. ncbi request reprint Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells
    Carmen Gianfrani
    Institute of Food Science Consiglio Nazionale delle Ricerche, Avellino, Italy
    J Immunol 177:4178-86. 2006
    ..In conclusion, dietary Ag-specific Tr1 cells are present in the human intestinal mucosa, and strategies to boost their numbers and/or function may offer new therapeutic opportunities to restore gut homeostasis...
  41. pmc Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells
    Cindy S Ma
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Invest 115:1049-59. 2005
    ..Thus, insufficient IL-10 production may contribute to hypogammaglobulinemia in XLP. This finding suggests new strategies for treating this immunodeficiency...
  42. ncbi request reprint Role of regulatory T cells and FOXP3 in human diseases
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
    J Allergy Clin Immunol 120:227-35; quiz 236-7. 2007
    ..Interestingly, there is increasing evidence that the individual signature of genes relevant for immune regulation definitely influences the final outcome of an immune response...
  43. ncbi request reprint Immunological lessons learnt from patients transplanted with fully mismatched stem cells
    Jean Louis Touraine
    Department of Transplantation and Clinical Immunology, Claude Bernard University and Edouard Herriot Hospital, Lyon, France
    Immunol Res 38:201-9. 2007
    ..Tolerance to donor antigens was acquired by clonal deletion; tolerance to host antigens existed despite the presence of many host-reactive T-cells and involved clonal anergy...
  44. pmc Development of lentiviral gene therapy for Wiskott Aldrich syndrome
    Anne Galy
    Head of Immunology and Gene Therapy Group, INSERM U790, Genethon, 1 bis rue de l Internationale, 91002 Evry, France
    Expert Opin Biol Ther 8:181-90. 2008
    ..WAS is attracting growing attention not only because it highlights the rich cellular and systems biology revolving around cytoskeletal regulation but also because it is candidate for a haematopoietic stem cell gene therapy indication...