Maurilio Ponzoni

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Cervical thymic hyperplasia after chemotherapy in an adult patient with Hodgkin lymphoma: a potential cause of false-positivity on [18F]FDG PET/CT scanning
    Federico Fallanca
    Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy
    Br J Haematol 140:477. 2008
  2. pmc A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma
    Maurilio Ponzoni
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 18:876-84. 2013
  3. doi request reprint Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Am J Surg Pathol 36:1609-18. 2012
  4. doi request reprint Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, Milano, Italy
    Clin Cancer Res 14:5794-800. 2008
  5. doi request reprint Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Pathol 42:738-42. 2011
  6. ncbi request reprint Isolated bone marrow manifestation of HIV-associated Hodgkin lymphoma
    Maurilio Ponzoni
    Department of Pathology, S Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 15:1273-8. 2002
  7. ncbi request reprint A virtual tissue bank for primary central nervous system lymphomas in immunocompetent individuals
    Maurilio Ponzoni
    Division of Pathology, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Pathobiology 74:264-9. 2007
  8. ncbi request reprint Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants
    M Ponzoni
    Departments of Pathology, S Raffaele H Scientific Institute, Milan, Italy
    Ann Oncol 13:1827-32. 2002
  9. ncbi request reprint Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting
    Maurilio Ponzoni
    Unit of Lymphoma Malignancies, Pathology and Oncology Units, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 25:3168-73. 2007
  10. ncbi request reprint Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas
    M Ponzoni
    Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Br J Haematol 138:316-23. 2007

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Cervical thymic hyperplasia after chemotherapy in an adult patient with Hodgkin lymphoma: a potential cause of false-positivity on [18F]FDG PET/CT scanning
    Federico Fallanca
    Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy
    Br J Haematol 140:477. 2008
  2. pmc A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma
    Maurilio Ponzoni
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 18:876-84. 2013
    ..This review covers the prevalence, clinical presentation, behavior, and histological and molecular features of uncommon forms of primary OAL and provides practical recommendations for therapeutic management. ..
  3. doi request reprint Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Am J Surg Pathol 36:1609-18. 2012
    ..However, presently it is not possible to distinguish SMZL from SDRL on the basis of BMB evaluation alone; hence, histopathologic examination of the spleen remains the "gold standard" approach...
  4. doi request reprint Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, Milano, Italy
    Clin Cancer Res 14:5794-800. 2008
    ..Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas...
  5. doi request reprint Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Pathol 42:738-42. 2011
    ..This observation points toward the opportunity to investigate the prevalence of C psittaci infection in central nervous system lymphomas, particularly in those with low-grade histologic features...
  6. ncbi request reprint Isolated bone marrow manifestation of HIV-associated Hodgkin lymphoma
    Maurilio Ponzoni
    Department of Pathology, S Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 15:1273-8. 2002
    ..A rapid diagnosis of isolated bone marrow HIV-associated Hodgkin lymphoma could expedite therapy...
  7. ncbi request reprint A virtual tissue bank for primary central nervous system lymphomas in immunocompetent individuals
    Maurilio Ponzoni
    Division of Pathology, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Pathobiology 74:264-9. 2007
    ..ielsg.org. Only anonymous data are centralized at the website of the International Extranodal Lymphoma Study Group, whilst the pathologic material is maintained at the local pathology institutes...
  8. ncbi request reprint Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variants
    M Ponzoni
    Departments of Pathology, S Raffaele H Scientific Institute, Milan, Italy
    Ann Oncol 13:1827-32. 2002
    ..The neuroimaging picture was not specific. A comparison with literature data concerning the clinical/instrumental features shows a very frequent meningeal involvement in PCNSL ALCLs, in contrast to the majority of PCNSLs...
  9. ncbi request reprint Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting
    Maurilio Ponzoni
    Unit of Lymphoma Malignancies, Pathology and Oncology Units, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 25:3168-73. 2007
    ..Finally, a provisional practical diagnostic approach to hemophagocytosis-associated patients and a proposal for the most useful criteria in the settings of differential diagnosis are included...
  10. ncbi request reprint Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas
    M Ponzoni
    Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Br J Haematol 138:316-23. 2007
    ..In conclusion, the presence of RPVI is independently associated with survival in PCNSL. This parameter can be easily and routinely assessed at diagnosis on histopathological specimens...
  11. ncbi request reprint Chronic lymphocytic leukemia: the pathologist's view of lymph node microenvironment
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, University Scientific Institute San Raffaele, Milan, Italy
    Semin Diagn Pathol 28:161-6. 2011
    ..Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment...
  12. pmc Prevalence of Borrelia burgdorferi infection in a series of 98 primary cutaneous lymphomas
    Maurilio Ponzoni
    Pathology Unit, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 16:1582-8. 2011
    ..burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients...
  13. ncbi request reprint Intravascular lymphoma: a neoplasm of 'homeless' lymphocytes?
    Maurilio Ponzoni
    Pathology Unit, San Raffaele H Scientific Institute, Milan, Italy
    Hematol Oncol 24:105-12. 2006
    ..The present review will discuss the most recent acquisitions related either to diagnosis and immunophenotypic/biologic characteristics as well as clinical/therapeutic issues of IVL...
  14. ncbi request reprint Isolated bone marrow occurrence of classic Hodgkin's lymphoma in an HIV-negative patient
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milan, Italy
    Haematologica 91:ECR04. 2006
    ..The impacts of such unusual Hodgkin's Lymphoma manifestation on clinical practice as well as the related diagnostic and therapeutic implications are discussed...
  15. ncbi request reprint Extramedullary myeloid cell tumor/granulocytic sarcoma with predilection for serosal surfaces
    Maurilio Ponzoni
    Department of Pathology, Scientific Intitute Ospedale S Raffaele HSR, Milano, Italy
    Haematologica 87:ECR09. 2002
  16. ncbi request reprint Prognostic value of bcl-6, CD10 and CD38 immunoreactivity in stage I-II gastric lymphomas: identification of a subset of CD10+ large B-cell lymphomas with a favorable outcome
    Maurilio Ponzoni
    Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
    Int J Cancer 106:288-91. 2003
    ..Accordingly, patients with CD10(+) gastric large B-cell lymphomas may be at reduced risk and eligible for clinical trials evaluating more conservative therapeutic options...
  17. ncbi request reprint Mutations of the 5' noncoding region of the BCL-6 gene in primary bone lymphomas
    Umberto Gianelli
    Department of Medicine, Surgery and Dental Sciences, Pathology Unit, University of Milan School of Medicine, A O S Paolo and IRCCS Ospedale Maggiore, Milan, Italy
    Ann Hematol 82:691-5. 2003
    ..The prevalence of mutations was higher in stage I(E) PBL than in more advanced stages of the disease (II(E) + IV) ( p=0.02). Our results reinforce the observation of heterogeneity of the DLBCL included in the clinical category of PBL...
  18. doi request reprint The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma
    Andres J M Ferreri
    Unit of Lymphoid Malignancies and Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milano, Italy
    Br J Haematol 143:253-7. 2008
    ..50%; P = 0.04), event-free survival (3-year: 89% vs. 35%; P = 0.003) and overall survival (3-year: 89% vs. 38%; P = 0.01). In conclusion, rituximab may substantially change the dismal prognosis of IVL...
  19. ncbi request reprint Ganciclovir is associated with low or undetectable Epstein-Barr virus DNA load in cerebrospinal fluid of patients with HIV-related primary central nervous system lymphoma
    Simona Bossolasco
    Clinic of Infectious Diseases, San Raffaele Hospital, Milan, Italy
    Clin Infect Dis 42:e21-5. 2006
    ..The objective of this study was to assess the effect of ganciclovir on EBV DNA replication in patients with HIV-related PCNSL...
  20. doi request reprint Chlamydophila psittaci is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: results of a single-center prospective case-control study
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Int J Cancer 123:1089-93. 2008
    ..Cp infection is common in OAML patients and exceptional in blood donors. Epidemiological data of OAML patients (prolonged contact with household animals and chronic conjunctivitis) are consistent with Cp exposure risk...
  21. pmc Clinical relevance of the dose of cytarabine in the upfront treatment of primary CNS lymphomas with methotrexate-cytarabine combination
    Andres J M Ferreri
    Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Oncologist 16:336-41. 2011
    ..With respect to MTX-araC combination, araC dose was halved to minimize toxicity. Herein, we report tolerability, activity, and efficacy of MAT regimen and compare these results to those previously reported with MTX/ara-C combination...
  22. ncbi request reprint Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Natl Cancer Inst 98:1375-82. 2006
    ..The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested...
  23. doi request reprint CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
    Monica Casucci
    Leukemia Immunotherapy Group, San Raffaele Scientific Institute, Milan, Italy
    Blood 122:3461-72. 2013
    ..These results warrant the clinical investigation of suicidal CD44v6-targeted T cells in AML and MM. ..
  24. ncbi request reprint Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation
    Fabio Ciceri
    Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 109:4698-707. 2007
    ..These data validate the feasibility, safety, and efficacy of TK(+) cells in the context of allografting and represent the basis for a broader application of this technology...
  25. pmc The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
    Eugenio Montini
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Clin Invest 119:964-75. 2009
    ..Our findings strongly support the use of SIN viral vector platforms and show that ISS can substantially modulate genotoxicity...
  26. doi request reprint HS1 has a central role in the trafficking and homing of leukemic B cells
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 116:3537-46. 2010
    ..These findings show that HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in CLL...
  27. doi request reprint Chlamydophila psittaci eradication with doxycycline as first-line targeted therapy for ocular adnexae lymphoma: final results of an international phase II trial
    Andres J M Ferreri
    San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 30:2988-94. 2012
    ..To our knowledge, this is the first international phase II trial aimed at clarifying Cp prevalence and activity of first-line doxycycline in a homogeneous series of consecutive patients with newly diagnosed stage I OAMZL...
  28. doi request reprint IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes
    Shin Kaneko
    Experimental Hematology Unit, Cancer Immunotherapy and Gene Therapy Program, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 113:1006-15. 2009
    ..GVHD was halted through the activation of the suicide gene machinery. These results warrant the use of suicide gene-modified T(CM) cells cultured with IL-7 and IL-15 for the safe exploitation of the alloreactive response against cancer...
  29. doi request reprint High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Lancet 374:1512-20. 2009
    ..We assessed the effect of adding high-dose cytarabine to methotrexate in patients with newly diagnosed primary CNS lymphoma...
  30. ncbi request reprint Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    J Natl Cancer Inst 96:586-94. 2004
    ..Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas...
  31. ncbi request reprint Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Clin Oncol 23:5067-73. 2005
    ..The present pilot study was carried out to assess whether C psittaci-eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas...
  32. ncbi request reprint Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Br J Haematol 127:173-83. 2004
    ..ECOG-PS >1, 'cutaneous variant', stage I and chemotherapy use were independently associated with improved survival...
  33. pmc Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene
    Monica Casucci
    Experimental Hematology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Mol Ther 21:466-75. 2013
    ..These results warrant the clinical investigation of L-APC-expanded T cells modified with a suicide gene in the setting of haplo-HSCT...
  34. doi request reprint Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia
    Elisa ten Hacken
    Division of Molecular Oncology, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Blood 121:2264-73. 2013
    ..Thus LYN/HS1 axis marks distinct signaling profiles and cytoskeletal-related features that may represent valuable targets for cytoskeleton-targeted therapeutic intervention in CLL...
  35. ncbi request reprint Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Haematologica 92:486-92. 2007
    ..This study explored variations in the clinical manifestations of intravascular lymphoma (IVL) on the bases of the association with hemophagocytosis and the country where the diagnosis was made...
  36. doi request reprint Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study
    Fabio Ciceri
    Haematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy
    Lancet Oncol 10:489-500. 2009
    ..We aimed to systematically add back genetically engineered donor lymphocytes to facilitate immune reconstitution and prevent late mortality...
  37. ncbi request reprint Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity
    Marco Catucci
    TIGET, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 44:1039-45. 2014
    ..In summary, for the first time, we demonstrate in in vivo models that WASP deficiency affects resistance to tumor and causes impairment in the antitumor capacity of NK cells and DCs. ..
  38. ncbi request reprint Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects
    Alessandra Mortellaro
    Via Olgettina 58, 20132, Milan, Italy
    Blood 108:2979-88. 2006
    ..Overall, this study demonstrates the efficacy of LV gene transfer in correcting both the immunological and metabolic phenotypes of ADA-SCID and supports the future clinical use of this approach...
  39. ncbi request reprint Therapeutic management of ocular adnexal MALT lymphoma
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 6020132, Milan, Italy
    Expert Opin Pharmacother 8:1073-83. 2007
    ..In this review, the authors analyze related literature and propose therapeutic guidelines for the management of ocular adnexal lymphoma of MALT-type...
  40. doi request reprint Chlamydial infection: the link with ocular adnexal lymphomas
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Nat Rev Clin Oncol 6:658-69. 2009
    ..Available data on the epidemiology, biology and pathogenesis of this association are analyzed and new investigative and clinical approaches are discussed...
  41. pmc Autologous pancreatic islet transplantation in human bone marrow
    Paola Maffi
    Islet Transplantation Unit, Diabetes Research Institute, Ospedale San Raffaele, Milan, Italy
    Diabetes 62:3523-31. 2013
    ..Moreover, this is the first unequivocal example of successful engraftment of endocrine tissue in the BM in humans. ..
  42. ncbi request reprint Questions and answers in the management of primary central nervous system and ocular lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Haematologica 88:1063-8. 2003
  43. doi request reprint Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
    Maria Teresa Sabrina Bertilaccio
    Division of Molecular Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 118:660-9. 2011
    ..This study reveals an important pathogenetic implication of TLR in CLL development and progression...
  44. doi request reprint Gastric lymphoma: the histology report
    Claudio Doglioni
    Department of Pathology, Scientific Institute San Raffaele, Milan, Italy
    Dig Liver Dis 43:S310-8. 2011
    ..This paper aims at giving the histopathologist a general knowledge about the state of art of this disease and its management. The diagnostic process leading to a complete and competent report is then described step by step...
  45. doi request reprint Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
    Eduardo J Villablanca
    Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
    Nat Med 16:98-105. 2010
    ..The manipulation of this pathway could restore antitumor immunity in individuals with cancer...
  46. doi request reprint Stable knockdown of microRNA in vivo by lentiviral vectors
    Bernhard Gentner
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Nat Methods 6:63-6. 2009
    ..We used bone marrow reconstitution with hematopoietic stem cells stably overexpressing miR-223 target sequence to phenocopy the genetic miR-223 knockout mouse, indicating robust interference of microRNA function in vivo...
  47. doi request reprint A novel Rag2-/-gammac-/--xenograft model of human CLL
    Maria Teresa Sabrina Bertilaccio
    Laboratory of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Blood 115:1605-9. 2010
    ..This model closely resembles aggressive human CLL and could be very useful for evaluating both the biologic basis of CLL growth and dissemination as well as the efficacy of new therapeutic agents...
  48. ncbi request reprint Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: clinical and therapeutic implications
    Andrés Jm Ferreri
    Medical Oncology Unit, San Raffaele H Scientific Institute, Milan, Italy
    Hematol Oncol 24:33-7. 2006
    ....
  49. ncbi request reprint Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Br J Haematol 126:657-64. 2004
    ..If confirmed in prospective trials on PCNSL treated with HD-MTX alone, these data may suggest the necessity for alternative strategies in M-PCNSL considering the increased risk of MTX resistance by tumour cells...
  50. pmc Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models
    Francesco Marangoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Mol Ther 17:1073-82. 2009
    ..Demonstration of long-term efficacy and safety of WAS gene therapy mediated by a clinically applicable LV is a key step toward the implementation of a gene therapy clinical trial for WAS...
  51. doi request reprint Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs
    Sara Trifari
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Allergy Clin Immunol 125:439-448.e8. 2010
    ..Secondary mutations leading to re-expression of WAS protein (WASP) are relatively frequent in patients with WAS...
  52. ncbi request reprint Marginal zone lymphomas and infectious agents
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy Division of Onco Hematological Medicine, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy Electronic address
    Semin Cancer Biol 23:431-40. 2013
    ..Biological and clinical features, therapeutic implications and future perspectives of these lymphoma-microbial associations are discussed in this review. ..
  53. ncbi request reprint Immunoreactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation
    Giancarlo Pruneri
    Divisions of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    J Pathol 200:596-601. 2003
    ..000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms...
  54. ncbi request reprint Plasma cells require autophagy for sustainable immunoglobulin production
    Niccolò Pengo
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
    Nat Immunol 14:298-305. 2013
    ..Thus, autophagy is specifically required for plasma cell homeostasis and long-lived humoral immunity...
  55. ncbi request reprint Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma
    Luca Agnelli
    Department of Clinical Sciences and Community Health, University of Milano, Hematology 1, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    Blood 120:1274-81. 2012
    ..In conclusion, our data justify the possibility of translating quantitative RT-PCR protocols to routine clinical settings as a new approach to objectively dissect T-NHL and to select more appropriate therapeutic protocols...
  56. ncbi request reprint Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining
    Maurilio Ponzoni
    Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 17:1513-20. 2004
    ..These findings provide a rationale for the investigational use of anti-CD105-targeted drugs in CIMF...
  57. ncbi request reprint Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    J Clin Oncol 21:266-72. 2003
    ..To identify survival predictors and to design a prognostic score useful for distinguishing risk groups in immunocompetent patients with primary CNS lymphomas (PCNSL)...
  58. ncbi request reprint Lymphomas of the bone: a pathological and clinical study of 54 cases
    Umberto Gianelli
    Departement of Medicine, Surgery and Dental Sciences, AO S Paolo HSP, Milan, Italy
    Int J Surg Pathol 10:257-66. 2002
    ..This study details the clinical and pathological characteristics of bone lymphomas. Our immunohistochemical and molecular data suggest that most of them are "de novo" DLBCL and support their follicle center origin...
  59. doi request reprint The role of Helicobacter pylori eradication in the treatment of diffuse large B-cell and marginal zone lymphomas of the stomach
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Curr Opin Oncol 25:470-9. 2013
    ..This review is focused on the effect of Helicobacter pylori eradication with antibiotics in patients with primary gastric lymphomas of indolent and aggressive nature...
  60. ncbi request reprint Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes
    Attilio Bondanza
    Experimental Hematology Laboratory, Cancer Immunotherapy and Gene Therapy Program, Università Vita Salute S Raffaele, Pathology Unit, Telethon Institute for Gene Therapy, Milan, Italy
    Blood 107:1828-36. 2006
    ..GCV administration efficiently controlled GvHD induced by CM TK+ lymphocytes. These results warrant the clinical investigation of CM suicide gene-modified human T lymphocytes for safe and effective allo-HCT...
  61. pmc Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
    Kevin Goudy
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Clin Immunol 146:248-61. 2013
    ..Thus, the complex pathogenesis of CD25 deficiency provides invaluable insight into the role of IL2/IL-2RA-dependent regulation in autoimmunity and inflammatory diseases...
  62. ncbi request reprint Ocular adnexal lymphoma: diffusion-weighted mr imaging for differential diagnosis and therapeutic monitoring
    Letterio S Politi
    Department of Neuroradiology and Neuroradiology Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy it
    Radiology 256:565-74. 2010
    ....
  63. pmc In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia
    Annarita Miccio
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 105:10547-52. 2008
    ..These data provide a rationale for a gene therapy approach to beta-thalassemia based on partially myeloablative transplantation protocols...
  64. pmc Human herpesvirus 6A accelerates AIDS progression in macaques
    Paolo Lusso
    Unit of Human Virology, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 104:5067-72. 2007
    ..Rapid disease development in dually infected animals was heralded by an early depletion of both CD4(+) and CD8(+) T cells. These results provide in vivo evidence that HHV-6A may act as a promoting factor in AIDS progression...
  65. ncbi request reprint Primary stage I-IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients
    Elisabetta Garavaglia
    Division of Gynecology and Obstetrics, University Vita e Salute, S Raffaele Hospital, V Olgettina 60, 20132 Milan, Italy
    Gynecol Oncol 97:214-8. 2005
    ..However, these organs are rarely the site of origin of this type of neoplasia. Because of the rarity of primary genital tract lymphomas, a standard treatment has not been defined...
  66. doi request reprint Bone marrow as an alternative site for islet transplantation
    Elisa Cantarelli
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Blood 114:4566-74. 2009
    ..The results of our study open a research line with potentially significant clinical impact, not only for the treatment of diabetes, but also for other diseases amenable to treatment with cellular transplantation...
  67. ncbi request reprint Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    Mary Anna Venneri
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Blood 109:5276-85. 2007
    ..Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy...
  68. ncbi request reprint Epstein-Barr virus DNA load in cerebrospinal fluid and plasma of patients with AIDS-related lymphoma
    Simona Bossolasco
    Clinic of Infectious Diseases, San Raffaele Hospital, Milan, Italy
    J Neurovirol 8:432-8. 2002
    ..High CSF EBV DNA levels were found in HIV-associated brain lymphomas and the viral load can be clinically useful. High plasma EBV DNA levels might predict CNS involvement in systemic NHL...
  69. ncbi request reprint Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphoma
    F Folli
    Department of Medicine I, I R C C S H S Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Ann Hematol 81:597-602. 2002
    ..Autoantibodies directed against this novel membrane autoantigen may be an additional serological marker in some cases of Sjögren's syndrome...
  70. ncbi request reprint A multicenter study of treatment of primary CNS lymphoma
    A J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Neurology 58:1513-20. 2002
    ..To characterize the therapeutic variables correlated to outcome in 370 patients with primary CNS lymphoma...
  71. ncbi request reprint Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma
    A J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Ann Oncol 15:1215-21. 2004
    ..Optimal therapeutic management of intravascular lymphoma (IVL) lacks precise guidelines...
  72. ncbi request reprint Non-surgical treatment with primary chemotherapy, with or without radiation therapy, of stage I-II high-grade gastric lymphoma
    A J Ferreri
    Dept of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Leuk Lymphoma 33:531-41. 1999
    ....
  73. ncbi request reprint Relevance of intraocular involvement in the management of primary central nervous system lymphomas
    A J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Ann Oncol 13:531-8. 2002
    ..Reported data regarding intraocular lymphoma (IOL) management are anecdotal. Cases of IOL included in an international multicentre series of 378 immunocompetent patients with primary central nervous system lymphomas (PCNSLs) were reviewed...
  74. ncbi request reprint Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma
    R Crocchiolo
    Hematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy
    Ann Hematol 88:1229-36. 2009
    ..If FDG abnormal uptake is present at multiple nodal sites, subdiaphragmatic lymph nodes, or previous sites of disease, histological verification of PET abnormal findings is warranted...
  75. ncbi request reprint Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa
    A J M Ferreri
    Medical Oncology Unit, San Raffaele H Scientific Institute, Milan, Italy
    Ann Oncol 17:769-72. 2006
    ..A pathogenic link between hepatitis C virus (HCV) and MALT-type lymphomas has been suggested. However, studies assessing the role of HCV infection separately in different forms of MALT lymphomas are not available...
  76. ncbi request reprint Combined treatment with high-dose methotrexate, vincristine and procarbazine, without intrathecal chemotherapy, followed by consolidation radiotherapy for primary central nervous system lymphoma in immunocompetent patients
    A J Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Oncology 60:134-40. 2001
    ..Patients who achieved a complete remission were referred to RT, those with progressive disease were excluded from further study; all the remaining patients received a third course of CHT followed by RT...
  77. ncbi request reprint Re-occurrence of the CD20 molecule expression subsequent to CD20-negative relapse in diffuse large B-cell lymphoma
    A J Ferreri
    Medical Oncology Unit, Dept of Oncology, San Raffaele H Scientific Institute, Milan, Italy
    Haematologica 92:e1-2. 2007
    ..Accordingly, every relapse, whenever possible, should be histologically assessed with diagnostic and immunophenotyping purposes...
  78. ncbi request reprint Consolidation radiotherapy to bulky or semibulky lesions in the management of stage III-IV diffuse large B cell lymphomas
    A J Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Oncology 58:219-26. 2000
    ..To assess the impact on survival of consolidation radiotherapy to bulky or semibulky lesions in patients with advanced diffuse large B cell lymphoma (DLCL) in complete remission after primary chemotherapy...
  79. ncbi request reprint Prognostic significance of the histopathologic recognition of low- and high-grade components in stage I-II B-cell gastric lymphomas
    A J Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Am J Surg Pathol 25:95-102. 2001
    ..The presence of scattered LC 5%-10% appears irrelevant in LGML. LG component and LEL are favorable predictors in HG lymphomas, helping to identify two subsets of DLCL with different prognosis...
  80. ncbi request reprint Ocular adnexal MALT lymphoma: an intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapy
    A J M Ferreri
    Unit of Lymphoid Malignancies, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Ann Oncol 19:835-46. 2008
    ..In this review, we analyze the most relevant biological, molecular, pathological and clinical features of OAML and propose some therapeutic guidelines for patients affected by this malignancy...
  81. doi request reprint Lymphomatous neuropathy in cold agglutinin disease
    N Riva
    Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1715-6. 2008
  82. ncbi request reprint Immunoreactivity for p27(KIP1) and cyclin E is an independent predictor of survival in primary gastric non-Hodgkin's lymphoma
    A J Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Int J Cancer 94:599-604. 2001
    ..The predictive role of these molecules within each histologic group of PGLs deserves to be confirmed in larger series...
  83. ncbi request reprint MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas
    A J M Ferreri
    Medical Oncology Unit, San Raffaele H Scientific Institute, Universita Vita Salute San Raffaele, Milan, Italy
    Neurology 66:1435-8. 2006
    ..Myelosuppression was the dose-limiting toxicity, with 9.5% of lethal complications. After a median follow-up of 49 months, a plateau in the survival curve (5-year overall survival: 41 +/- 7%) was obtained...
  84. ncbi request reprint Plasma cell granuloma of the thyroid gland: a challenging diagnostic problem
    Anna Cremonini
    San Raffaele Scientific Institute, Milan, Italy
    Int J Surg Pathol 20:500-6. 2012
    ..In view of these considerations, a contemporary diagnostic approach to thyroid plasma cell granuloma is therefore discussed here...
  85. ncbi request reprint New transcription factors in diagnostic hematopathology
    Maurilio Ponzoni
    Pathology Unit, Scientific Institute San Raffaele, Milano, Italy
    Adv Anat Pathol 14:25-35. 2007
    ..This field is rapidly evolving, as witnessed by the ongoing growing number of novel TFs with possible diagnostic applications appearing in the literature...
  86. doi request reprint Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
    Elena Provasi
    Experimental Hematology Unit, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Program of Immunology, Gene Therapy and Bio Immunotherapy of Cancer, Leukemia Unit, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 18:807-15. 2012
    ....
  87. pmc Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    PLoS ONE 4:e5959. 2009
    ..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs...
  88. pmc In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
    Greta Maria Paola Giordano Attianese
    Department of Pediatrics, University of Milano Bicocca, Milan, Italy
    Blood 117:4736-45. 2011
    ..CAR(+) T cells resulted in a significant delay in the growth of the MEC-1 CLL cell line. These data suggest that CD23.CAR(+) T cells represent a selective immunotherapy for the elimination of CD23(+) leukemic cells in patients with CLL...
  89. ncbi request reprint Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    Eugenio Montini
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132, Milan, Italy
    Nat Biotechnol 24:687-96. 2006
    ..Our results validate a much-needed platform to assess vector safety and provide direct evidence that prototypical lentiviral vectors have low oncogenic potential, highlighting a major rationale for application to gene therapy...
  90. ncbi request reprint Human herpesvirus 8 (HHV-8/KSHV) and hematologic malignancies
    Mauro S Malnati
    Unit of Human Virology DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
    Rev Clin Exp Hematol 7:375-405. 2003
    ..As seen with KS, the incidence of HHV-8-associated lymphoproliferative disorders is increased in the setting of human immunodeficiency virus infection...
  91. ncbi request reprint Mediastinal follicular dendritic cell sarcoma
    Giovanni Luca Ceresoli
    Department of Radiochemotherapy, San Raffaele Scientific Institute Hospital, Milan, Italy
    Haematologica 88:ECR04. 2003
  92. pmc Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Department of Regenerative Medicine, Stem Cells, and Gene Therapy, Milan, Italy
    Haematologica 95:2134-43. 2010
    ..Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for regulatory T-cell-based therapies...
  93. doi request reprint Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms
    Roberto Piva
    Department of Pathology, Center for Experimental Research and Medical Studies, Laboratory of Functional Genomics, University of Torino, Torino, Italy
    J Clin Oncol 28:1583-90. 2010
    ....
  94. ncbi request reprint Intravascular lymphomatosis (IL) in a child mimicking a posterior fossa tumor
    M Massimino
    Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
    J Neurooncol 51:47-50. 2001
    ..She remained alive in continuous complete remission at 21 months after diagnosis. The case here reported is unique for age, tumor presentation, and, so far, favourable outcome, in spite of the delayed histological diagnosis...
  95. ncbi request reprint Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantation
    Paolo Fiorina
    Department of Medicine I, San Raffaele Hospital, Milan, Italy
    Transplantation 75:1296-301. 2003
    ..The aim of this study was to evaluate the effects of islet transplantation on patient survival and diabetic vascular complications...
  96. doi request reprint Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma
    W Vermi
    Department of Pathology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy
    J Pathol 216:356-64. 2008
    ..In addition to the potential biological relevance of this expression, the use of reagents directed against CXCL13 can be useful to properly identify the origin of spindle cell and epithelioid neoplasms...
  97. ncbi request reprint Clinical activity of rituximab in gastric marginal zone non-Hodgkin's lymphoma resistant to or not eligible for anti-Helicobacter pylori therapy
    Giovanni Martinelli
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    J Clin Oncol 23:1979-83. 2005
    ....
  98. pmc Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano PN Italy
    J Virol 79:2643-9. 2005
    ....
  99. ncbi request reprint A woman and her canary: a tale of chlamydiae and lymphomas
    Andres J M Ferreri
    J Natl Cancer Inst 99:1418-9. 2007
  100. ncbi request reprint Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesis
    Erich Piovan
    Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Res 67:8605-14. 2007
    ..The unresponsiveness of GC-derived lymphomatous B cells to CXCR4 triggering under hypoxia may have implications for the development and pathogenesis of GC-derived lymphoid tumors...
  101. ncbi request reprint Rituximab in patients with mucosal-associated lymphoid tissue-type lymphoma of the ocular adnexa
    Andres J M Ferreri
    Haematologica 90:1578-9. 2005
    ..Four responding patients experienced early relapse. The median time to progression was 5 months. The efficacy of rituximab in ocular adnexal lymphoma is lower than that reported for gastric MALT lymphomas...