Research Topics
Genomes and Genes | Maurilio PonzoniSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Publications
Cervical thymic hyperplasia after chemotherapy in an adult patient with Hodgkin lymphoma: a potential cause of false-positivity on [18F]FDG PET/CT scanningFederico Fallanca
Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy
Br J Haematol 140:477. 2008
Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?Maurilio Ponzoni
Pathology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
Am J Surg Pathol 36:1609-18. 2012..However, presently it is not possible to distinguish SMZL from SDRL on the basis of BMB evaluation alone; hence, histopathologic examination of the spleen remains the "gold standard" approach...- Chronic lymphocytic leukemia: the pathologist's view of lymph node microenvironmentMaurilio Ponzoni
Pathology Unit, Department of Oncology, University Scientific Institute San Raffaele, Milan, Italy
Semin Diagn Pathol 28:161-6. 2011..Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment... - Isolated bone marrow manifestation of HIV-associated Hodgkin lymphomaMaurilio Ponzoni
Department of Pathology, S Raffaele H Scientific Institute, Milan, Italy
Mod Pathol 15:1273-8. 2002..A rapid diagnosis of isolated bone marrow HIV-associated Hodgkin lymphoma could expedite therapy... 
Prevalence of Borrelia burgdorferi infection in a series of 98 primary cutaneous lymphomasMaurilio Ponzoni
Pathology Unit, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
Oncologist 16:1582-8. 2011..burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients...- Primary brain CD30+ ALK1+ anaplastic large cell lymphoma ('ALKoma'): the first case with a combination of 'not common' variantsM Ponzoni
Departments of Pathology, S Raffaele H Scientific Institute, Milan, Italy
Ann Oncol 13:1827-32. 2002.... - Prognostic value of bcl-6, CD10 and CD38 immunoreactivity in stage I-II gastric lymphomas: identification of a subset of CD10+ large B-cell lymphomas with a favorable outcomeMaurilio Ponzoni
Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
Int J Cancer 106:288-91. 2003..Accordingly, patients with CD10(+) gastric large B-cell lymphomas may be at reduced risk and eligible for clinical trials evaluating more conservative therapeutic options... - Isolated bone marrow occurrence of classic Hodgkin's lymphoma in an HIV-negative patientMaurilio Ponzoni
Pathology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milan, Italy
Haematologica 91:ECR04. 2006..The impacts of such unusual Hodgkin's Lymphoma manifestation on clinical practice as well as the related diagnostic and therapeutic implications are discussed... - Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomasM Ponzoni
Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
Br J Haematol 138:316-23. 2007..In conclusion, the presence of RPVI is independently associated with survival in PCNSL. This parameter can be easily and routinely assessed at diagnosis on histopathological specimens... - Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infectionMaurilio Ponzoni
Pathology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
Hum Pathol 42:738-42. 2011..This observation points toward the opportunity to investigate the prevalence of C psittaci infection in central nervous system lymphomas, particularly in those with low-grade histologic features... - Extramedullary myeloid cell tumor/granulocytic sarcoma with predilection for serosal surfacesMaurilio Ponzoni
Department of Pathology, Scientific Intitute Ospedale S.Raffaele HSR, Milano, Italy
Haematologica 87:ECR09. 2002 - Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meetingMaurilio Ponzoni
Unit of Lymphoma Malignancies, Pathology and Oncology Units, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
J Clin Oncol 25:3168-73. 2007..Finally, a provisional practical diagnostic approach to hemophagocytosis-associated patients and a proposal for the most useful criteria in the settings of differential diagnosis are included... - A virtual tissue bank for primary central nervous system lymphomas in immunocompetent individualsMaurilio Ponzoni
Division of Pathology, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
Pathobiology 74:264-9. 2007..ielsg.org. Only anonymous data are centralized at the website of the International Extranodal Lymphoma Study Group, whilst the pathologic material is maintained at the local pathology institutes... - Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methodsMaurilio Ponzoni
Pathology Unit, San Raffaele Scientific Institute, Milano, Italy
Clin Cancer Res 14:5794-800. 2008..Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas... - Intravascular lymphoma: a neoplasm of 'homeless' lymphocytes?Maurilio Ponzoni
Pathology Unit, San Raffaele H Scientific Institute, Milan, Italy
Hematol Oncol 24:105-12. 2006..The present review will discuss the most recent acquisitions related either to diagnosis and immunophenotypic/biologic characteristics as well as clinical/therapeutic issues of IVL... - The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphomaAndres J M Ferreri
Unit of Lymphoid Malignancies and Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milano, Italy
Br J Haematol 143:253-7. 2008..50%; P = 0.04), event-free survival (3-year: 89% vs. 35%; P = 0.003) and overall survival (3-year: 89% vs. 38%; P = 0.01). In conclusion, rituximab may substantially change the dismal prognosis of IVL... - Ganciclovir is associated with low or undetectable Epstein-Barr virus DNA load in cerebrospinal fluid of patients with HIV-related primary central nervous system lymphomaSimona Bossolasco
Clinic of Infectious Diseases, San Raffaele Hospital, Milan, Italy
Clin Infect Dis 42:e21-5. 2006..The objective of this study was to assess the effect of ganciclovir on EBV DNA replication in patients with HIV-related PCNSL... - Chlamydophila psittaci is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: results of a single-center prospective case-control studyAndres J M Ferreri
Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
Int J Cancer 123:1089-93. 2008..Cp infection is common in OAML patients and exceptional in blood donors. Epidemiological data of OAML patients (prolonged contact with household animals and chronic conjunctivitis) are consistent with Cp exposure risk... - Mutations of the 5' noncoding region of the BCL-6 gene in primary bone lymphomasUmberto Gianelli
Department of Medicine, Surgery and Dental Sciences, Pathology Unit, University of Milan School of Medicine, A O S Paolo and IRCCS Ospedale Maggiore, Milan, Italy
Ann Hematol 82:691-5. 2003..The prevalence of mutations was higher in stage I(E) PBL than in more advanced stages of the disease (II(E) + IV) ( p=0.02). Our results reinforce the observation of heterogeneity of the DLBCL included in the clinical category of PBL... - Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantationFabio Ciceri
Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
Blood 109:4698-707. 2007..These data validate the feasibility, safety, and efficacy of TK(+) cells in the context of allografting and represent the basis for a broader application of this technology... - Clinical relevance of the dose of cytarabine in the upfront treatment of primary CNS lymphomas with methotrexate-cytarabine combinationAndres J M Ferreri
Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Oncologist 16:336-41. 2011..With respect to MTX-araC combination, araC dose was halved to minimize toxicity. Herein, we report tolerability, activity, and efficacy of MAT regimen and compare these results to those previously reported with MTX/ara-C combination... - HS1 has a central role in the trafficking and homing of leukemic B cellsCristina Scielzo
Unit of Lymphoid Malignancies, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
Blood 116:3537-46. 2010..These findings show that HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in CLL... - Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trialAndres J M Ferreri
Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
J Natl Cancer Inst 98:1375-82. 2006..The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested... - High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trialAndres J M Ferreri
Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
Lancet 374:1512-20. 2009..We assessed the effect of adding high-dose cytarabine to methotrexate in patients with newly diagnosed primary CNS lymphoma... - Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapyAndres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
J Clin Oncol 23:5067-73. 2005..The present pilot study was carried out to assess whether C psittaci-eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas... - Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomasAndres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
J Natl Cancer Inst 96:586-94. 2004..Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas... - The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapyEugenio Montini
San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
J Clin Invest 119:964-75. 2009..Our findings strongly support the use of SIN viral vector platforms and show that ISS can substantially modulate genotoxicity... - Chlamydophila psittaci eradication with doxycycline as first-line targeted therapy for ocular adnexae lymphoma: final results of an international phase II trialAndres J M Ferreri
San Raffaele Scientific Institute, Milan, Italy
J Clin Oncol 30:2988-94. 2012..To our knowledge, this is the first international phase II trial aimed at clarifying Cp prevalence and activity of first-line doxycycline in a homogeneous series of consecutive patients with newly diagnosed stage I OAMZL... - IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytesShin Kaneko
Experimental Hematology Unit, Cancer Immunotherapy and Gene Therapy Program, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy
Blood 113:1006-15. 2009..GVHD was halted through the activation of the suicide gene machinery. These results warrant the use of suicide gene-modified T(CM) cells cultured with IL-7 and IL-15 for the safe exploitation of the alloreactive response against cancer... - Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II studyFabio Ciceri
Haematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy
Lancet Oncol 10:489-500. 2009..We aimed to systematically add back genetically engineered donor lymphocytes to facilitate immune reconstitution and prevent late mortality... - Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regionsAndres J M Ferreri
Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
Haematologica 92:486-92. 2007..This study explored variations in the clinical manifestations of intravascular lymphoma (IVL) on the bases of the association with hemophagocytosis and the country where the diagnosis was made... - Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defectsAlessandra Mortellaro
Via Olgettina 58, 20132, Milan, Italy
Blood 108:2979-88. 2006..Overall, this study demonstrates the efficacy of LV gene transfer in correcting both the immunological and metabolic phenotypes of ADA-SCID and supports the future clinical use of this approach... - Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'Andres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Br J Haematol 127:173-83. 2004..ECOG-PS >1, 'cutaneous variant', stage I and chemotherapy use were independently associated with improved survival... - Chlamydial infection: the link with ocular adnexal lymphomasAndres J M Ferreri
Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
Nat Rev Clin Oncol 6:658-69. 2009..Available data on the epidemiology, biology and pathogenesis of this association are analyzed and new investigative and clinical approaches are discussed... - Therapeutic management of ocular adnexal MALT lymphomaAndres J M Ferreri
Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 6020132, Milan, Italy
Expert Opin Pharmacother 8:1073-83. 2007..In this review, the authors analyze related literature and propose therapeutic guidelines for the management of ocular adnexal lymphoma of MALT-type... - Questions and answers in the management of primary central nervous system and ocular lymphomasAndres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Haematologica 88:1063-8. 2003 - Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse modelsMaria Teresa Sabrina Bertilaccio
Division of Molecular Oncology, San Raffaele Scientific Institute, Milano, Italy
Blood 118:660-9. 2011..This study reveals an important pathogenetic implication of TLR in CLL development and progression... - Gastric lymphoma: the histology reportClaudio Doglioni
Department of Pathology, Scientific Institute San Raffaele, Milan, Italy
Dig Liver Dis 43:S310-8. 2011..This paper aims at giving the histopathologist a general knowledge about the state of art of this disease and its management. The diagnostic process leading to a complete and competent report is then described step by step... - Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responsesEduardo J Villablanca
Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
Nat Med 16:98-105. 2010..The manipulation of this pathway could restore antitumor immunity in individuals with cancer... - A novel Rag2-/-gammac-/--xenograft model of human CLLMaria Teresa Sabrina Bertilaccio
Laboratory of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
Blood 115:1605-9. 2010..This model closely resembles aggressive human CLL and could be very useful for evaluating both the biologic basis of CLL growth and dissemination as well as the efficacy of new therapeutic agents... - Stable knockdown of microRNA in vivo by lentiviral vectorsBernhard Gentner
San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
Nat Methods 6:63-6. 2009..We used bone marrow reconstitution with hematopoietic stem cells stably overexpressing miR-223 target sequence to phenocopy the genetic miR-223 knockout mouse, indicating robust interference of microRNA function in vivo... - Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: clinical and therapeutic implicationsAndrés Jm Ferreri
Medical Oncology Unit, San Raffaele H Scientific Institute, Milan, Italy
Hematol Oncol 24:33-7. 2006.... - Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomasAndres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Br J Haematol 126:657-64. 2004..If confirmed in prospective trials on PCNSL treated with HD-MTX alone, these data may suggest the necessity for alternative strategies in M-PCNSL considering the increased risk of MTX resistance by tumour cells... - Immunoreactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocationGiancarlo Pruneri
Divisions of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
J Pathol 200:596-601. 2003..000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms... - Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organsSara Trifari
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
J Allergy Clin Immunol 125:439-448.e8. 2010..Secondary mutations leading to re-expression of WAS protein (WASP) are relatively frequent in patients with WAS... - Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical modelsFrancesco Marangoni
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
Mol Ther 17:1073-82. 2009..Demonstration of long-term efficacy and safety of WAS gene therapy mediated by a clinically applicable LV is a key step toward the implementation of a gene therapy clinical trial for WAS... - Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphomaLuca Agnelli
Department of Clinical Sciences and Community Health, University of Milano, Hematology 1, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
Blood 120:1274-81. 2012..In conclusion, our data justify the possibility of translating quantitative RT-PCR protocols to routine clinical settings as a new approach to objectively dissect T-NHL and to select more appropriate therapeutic protocols... - Lymphomas of the bone: a pathological and clinical study of 54 casesUmberto Gianelli
Departement of Medicine, Surgery and Dental Sciences, AO S Paolo (HSP, Milan, Italy
Int J Surg Pathol 10:257-66. 2002..This study details the clinical and pathological characteristics of bone lymphomas. Our immunohistochemical and molecular data suggest that most of them are "de novo" DLBCL and support their follicle center origin... - Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experienceAndres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
J Clin Oncol 21:266-72. 2003..To identify survival predictors and to design a prognostic score useful for distinguishing risk groups in immunocompetent patients with primary CNS lymphomas (PCNSL)... - Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytesAttilio Bondanza
Experimental Hematology Laboratory, Cancer Immunotherapy and Gene Therapy Program, , Pathology Unit, Telethon Institute for Gene Therapy, Milan, Italy
Blood 107:1828-36. 2006..GCV administration efficiently controlled GvHD induced by CM TK+ lymphocytes. These results warrant the clinical investigation of CM suicide gene-modified human T lymphocytes for safe and effective allo-HCT... - Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostainingMaurilio Ponzoni
Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
Mod Pathol 17:1513-20. 2004..These findings provide a rationale for the investigational use of anti-CD105-targeted drugs in CIMF... - Primary stage I-IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patientsElisabetta Garavaglia
Division of Gynecology and Obstetrics, University Vita e Salute, S Raffaele Hospital, V Olgettina 60, 20132 Milan, Italy
Gynecol Oncol 97:214-8. 2005..However, these organs are rarely the site of origin of this type of neoplasia. Because of the rarity of primary genital tract lymphomas, a standard treatment has not been defined... - Ocular adnexal lymphoma: diffusion-weighted mr imaging for differential diagnosis and therapeutic monitoringLetterio S Politi
Department of Neuroradiology and Neuroradiology Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy it
Radiology 256:565-74. 2010.... - In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemiaAnnarita Miccio
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, 20132 Milan, Italy
Proc Natl Acad Sci U S A 105:10547-52. 2008..These data provide a rationale for a gene therapy approach to beta-thalassemia based on partially myeloablative transplantation protocols... - Human herpesvirus 6A accelerates AIDS progression in macaquesPaolo Lusso
Unit of Human Virology, San Raffaele Scientific Institute, 20132 Milan, Italy
Proc Natl Acad Sci U S A 104:5067-72. 2007..Rapid disease development in dually infected animals was heralded by an early depletion of both CD4(+) and CD8(+) T cells. These results provide in vivo evidence that HHV-6A may act as a promoting factor in AIDS progression... - Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancerMary Anna Venneri
San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Blood 109:5276-85. 2007..Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy... - Epstein-Barr virus DNA load in cerebrospinal fluid and plasma of patients with AIDS-related lymphomaSimona Bossolasco
Clinic of Infectious Diseases, San Raffaele Hospital, Milan, Italy
J Neurovirol 8:432-8. 2002..High CSF EBV DNA levels were found in HIV-associated brain lymphomas and the viral load can be clinically useful. High plasma EBV DNA levels might predict CNS involvement in systemic NHL... - Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexaA J M Ferreri
Medical Oncology Unit, San Raffaele H Scientific Institute, Milan, Italy
Ann Oncol 17:769-72. 2006..A pathogenic link between hepatitis C virus (HCV) and MALT-type lymphomas has been suggested. However, studies assessing the role of HCV infection separately in different forms of MALT lymphomas are not available... - Consolidation radiotherapy to bulky or semibulky lesions in the management of stage III-IV diffuse large B cell lymphomasA J Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Oncology 58:219-26. 2000..To assess the impact on survival of consolidation radiotherapy to bulky or semibulky lesions in patients with advanced diffuse large B cell lymphoma (DLCL) in complete remission after primary chemotherapy... - Anthracycline-based chemotherapy as primary treatment for intravascular lymphomaA J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Ann Oncol 15:1215-21. 2004..Optimal therapeutic management of intravascular lymphoma (IVL) lacks precise guidelines... - Prognostic significance of the histopathologic recognition of low- and high-grade components in stage I-II B-cell gastric lymphomasA J Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Am J Surg Pathol 25:95-102. 2001..The presence of scattered LC 5%-10% appears irrelevant in LGML. LG component and LEL are favorable predictors in HG lymphomas, helping to identify two subsets of DLCL with different prognosis... - Lymphomatous neuropathy in cold agglutinin diseaseN Riva
Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Neurology 70:1715-6. 2008 - Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphomaR Crocchiolo
Hematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy
Ann Hematol 88:1229-36. 2009..If FDG abnormal uptake is present at multiple nodal sites, subdiaphragmatic lymph nodes, or previous sites of disease, histological verification of PET abnormal findings is warranted... - Non-surgical treatment with primary chemotherapy, with or without radiation therapy, of stage I-II high-grade gastric lymphomaA J Ferreri
Dept of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Leuk Lymphoma 33:531-41. 1999.... - Ocular adnexal MALT lymphoma: an intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapyA J M Ferreri
Unit of Lymphoid Malignancies, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
Ann Oncol 19:835-46. 2008..In this review, we analyze the most relevant biological, molecular, pathological and clinical features of OAML and propose some therapeutic guidelines for patients affected by this malignancy... - Relevance of intraocular involvement in the management of primary central nervous system lymphomasA J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Ann Oncol 13:531-8. 2002..Reported data regarding intraocular lymphoma (IOL) management are anecdotal. Cases of IOL included in an international multicentre series of 378 immunocompetent patients with primary central nervous system lymphomas (PCNSLs) were reviewed... - MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomasA J M Ferreri
Medical Oncology Unit, San Raffaele H Scientific Institute, Universita Vita Salute San Raffaele, Milan, Italy
Neurology 66:1435-8. 2006..Myelosuppression was the dose-limiting toxicity, with 9.5% of lethal complications. After a median follow-up of 49 months, a plateau in the survival curve (5-year overall survival: 41 +/- 7%) was obtained... - Immunoreactivity for p27(KIP1) and cyclin E is an independent predictor of survival in primary gastric non-Hodgkin's lymphomaA J Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Int J Cancer 94:599-604. 2001..The predictive role of these molecules within each histologic group of PGLs deserves to be confirmed in larger series... - Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphomaF Folli
Department of Medicine I, I R C C S H S Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Ann Hematol 81:597-602. 2002..Autoantibodies directed against this novel membrane autoantigen may be an additional serological marker in some cases of Sjögren's syndrome... - A multicenter study of treatment of primary CNS lymphomaA J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Neurology 58:1513-20. 2002..To characterize the therapeutic variables correlated to outcome in 370 patients with primary CNS lymphoma... - Re-occurrence of the CD20 molecule expression subsequent to CD20-negative relapse in diffuse large B-cell lymphomaA J Ferreri
Medical Oncology Unit, Dept of Oncology, San Raffaele H Scientific Institute, Milan, Italy
Haematologica 92:e1-2. 2007..Accordingly, every relapse, whenever possible, should be histologically assessed with diagnostic and immunophenotyping purposes... - Combined treatment with high-dose methotrexate, vincristine and procarbazine, without intrathecal chemotherapy, followed by consolidation radiotherapy for primary central nervous system lymphoma in immunocompetent patientsA J Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
Oncology 60:134-40. 2001..Patients who achieved a complete remission were referred to RT, those with progressive disease were excluded from further study; all the remaining patients received a third course of CHT followed by RT... - Graft-versus-leukemia Effect of HLA-haploidentical Central-memory T-cells Expanded With Leukemic APCs and Modified With a Suicide GeneMonica Casucci
Experimental Hematology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
Mol Ther 21:466-75. 2013..These results warrant the clinical investigation of L-APC-expanded T cells modified with a suicide gene in the setting of haplo-HSCT... - Plasma cell granuloma of the thyroid gland: a challenging diagnostic problemAnna Cremonini
San Raffaele Scientific Institute, Milan, Italy
Int J Surg Pathol 20:500-6. 2012..In view of these considerations, a contemporary diagnostic approach to thyroid plasma cell granuloma is therefore discussed here... - Bone marrow as an alternative site for islet transplantationElisa Cantarelli
San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
Blood 114:4566-74. 2009..The results of our study open a research line with potentially significant clinical impact, not only for the treatment of diabetes, but also for other diseases amenable to treatment with cellular transplantation... - New transcription factors in diagnostic hematopathologyMaurilio Ponzoni
Pathology Unit, Scientific Institute San Raffaele, Milano, Italy
Adv Anat Pathol 14:25-35. 2007..This field is rapidly evolving, as witnessed by the ongoing growing number of novel TFs with possible diagnostic applications appearing in the literature... - Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transferElena Provasi
Experimental Hematology Unit, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Program of Immunology, Gene Therapy and Bio Immunotherapy of Cancer, Leukemia Unit, San Raffaele Scientific Institute, Milan, Italy
Nat Med 18:807-15. 2012.... - In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptorGreta Maria Paola Giordano Attianese
Department of Pediatrics, University of Milano Bicocca, Milan, Italy
Blood 117:4736-45. 2011..CAR(+) T cells resulted in a significant delay in the growth of the MEC-1 CLL cell line. These data suggest that CD23.CAR(+) T cells represent a selective immunotherapy for the elimination of CD23(+) leukemic cells in patients with CLL... - Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell functionStefano Pluchino
Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
PLoS ONE 4:e5959. 2009..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs... - Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integrationEugenio Montini
San Raffaele-Telethon Institute for Gene Therapy, Via Olgettina 58, 20132, Milan, Italy
Nat Biotechnol 24:687-96. 2006..Our results validate a much-needed platform to assess vector safety and provide direct evidence that prototypical lentiviral vectors have low oncogenic potential, highlighting a major rationale for application to gene therapy... - Human herpesvirus 8 (HHV-8/KSHV) and hematologic malignanciesMauro S Malnati
Unit of Human Virology DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
Rev Clin Exp Hematol 7:375-405. 2003..As seen with KS, the incidence of HHV-8-associated lymphoproliferative disorders is increased in the setting of human immunodeficiency virus infection... - Mediastinal follicular dendritic cell sarcomaGiovanni Luca Ceresoli
Department of Radiochemotherapy, San Raffaele Scientific Institute Hospital, Milan, Italy
Haematologica 88:ECR04. 2003 - Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapyRosa Bacchetta
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Department of Regenerative Medicine, Stem Cells, and Gene Therapy, Milan, Italy
Haematologica 95:2134-43. 2010..Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for regulatory T-cell-based therapies... - Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasmsRoberto Piva
Department of Pathology, Center for Experimental Research and Medical Studies, Laboratory of Functional Genomics, University of Torino, Torino, Italy
J Clin Oncol 28:1583-90. 2010.... - Intravascular lymphomatosis (IL) in a child mimicking a posterior fossa tumorM Massimino
Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
J Neurooncol 51:47-50. 2001..She remained alive in continuous complete remission at 21 months after diagnosis. The case here reported is unique for age, tumor presentation, and, so far, favourable outcome, in spite of the delayed histological diagnosis... - Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantationPaolo Fiorina
Department of Medicine I, San Raffaele Hospital, Milan, Italy
Transplantation 75:1296-301. 2003..CONCLUSIONS: Successful islet transplantation improves survival, atherothrombotic profile, and endothelial morphology in uremic type 1 diabetic kidney transplant patients... - Identification of CXCL13 as a new marker for follicular dendritic cell sarcomaW Vermi
Department of Pathology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy
J Pathol 216:356-64. 2008..In addition to the potential biological relevance of this expression, the use of reagents directed against CXCL13 can be useful to properly identify the origin of spindle cell and epithelioid neoplasms... - Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trialFrancesco Bertoni
Department of Experimental Haematology, Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
Blood 99:2541-4. 2002..The presence of molecular disease in the absence of histologic disease does not appear to be associated with histologic relapse, but, given the indolent nature of MALT lymphomas, a longer follow-up is needed... - Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patientsGiancarlo Pruneri
Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan, School of Medicine, Italy
Br J Haematol 118:817-20. 2002..01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001)... - Variable association between Chlamydophila psittaci infection and ocular adnexal lymphomas: methodological biases or true geographical variations?Didier Decaudin
Department of Clinical Hematology, Institut Curie, Paris, France
Anticancer Drugs 19:761-5. 2008..psittaci antibodies. This paper also provides some methodological suggestions for future studies in the field of chlamydia-lymphoma associations... - Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissueEmanuele Zucca
Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland
Blood 101:2489-95. 2003..Our data confirm the indolent nature of nongastric MALT lymphomas and the high rate of patients presenting with disseminated disease, which, when limited to mucosal sites, was not associated with a poorer outcome... - Rituximab in patients with mucosal-associated lymphoid tissue-type lymphoma of the ocular adnexaAndres J M Ferreri
Haematologica 90:1578-9. 2005..Four responding patients experienced early relapse. The median time to progression was 5 months. The efficacy of rituximab in ocular adnexal lymphoma is lower than that reported for gastric MALT lymphomas... - Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesisErich Piovan
Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Italy
Cancer Res 67:8605-14. 2007..The unresponsiveness of GC-derived lymphomatous B cells to CXCR4 triggering under hypoxia may have implications for the development and pathogenesis of GC-derived lymphoid tumors... - A woman and her canary: a tale of chlamydiae and lymphomasAndres J M Ferreri
J Natl Cancer Inst 99:1418-9. 2007 - Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative groupTamara N Shenkier
British Columbia Cancer Agency, 600 W 10th Ave, Vancouver, BC, V5Z 4E6, Canada
J Clin Oncol 23:2233-9. 2005..To describe the demographic and tumor related characteristics and outcomes for patients with primary T-cell CNS lymphoma (TPCNSL)... - Inherited perforin and Fas mutations in a patient with autoimmune lymphoproliferative syndrome and lymphomaRita Clementi
Department of Biology and Medical Genetics, University of Pavia, Pavia, Italy
N Engl J Med 351:1419-24. 2004..The combined effect of the two mutant genes may have contributed to the development of the autoimmune lymphoproliferative syndrome and lymphoma in this patient... - Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphomaMassimo Guidoboni
Immunovirology and Biotherapy Unit, Department of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano (PN) Italy
J Virol 79:2643-9. 2005.... - Clinical activity of rituximab in gastric marginal zone non-Hodgkin's lymphoma resistant to or not eligible for anti-Helicobacter pylori therapyGiovanni Martinelli
European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
J Clin Oncol 23:1979-83. 2005..The t(11; 18)(q21; q21) translocation seems not to be a predictive marker to response or to subsequent relapse... - Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomasAndrea Rinaldi
Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Br J Haematol 134:27-36. 2006..The combination of DNA copy number and LOH assessment lead to the hypothesis that uniparental disomy may be a potential mechanism in B-cell lymphomagenesis... - Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT typeAnnarita Conconi
Oncology Institute of Southern Switzerland, Division of Medical Oncology, Bellizona, Switzerland
Blood 102:2741-5. 2003..001). Most adverse events were of mild to moderate severity with no grade 4 toxicity. This study indicates that rituximab is safe with significant activity in MALT lymphomas... - Can rituximab change the usually dismal prognosis of patients with intravascular large B-cell lymphoma?Andres J M Ferreri
J Clin Oncol 26:5134-6; author reply 5136-7. 2008