Maurilio Ponzoni

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining
    Maurilio Ponzoni
    Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 17:1513-20. 2004
  2. doi CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
    Monica Casucci
    Leukemia Immunotherapy Group, San Raffaele Scientific Institute, Milan, Italy
    Blood 122:3461-72. 2013
  3. ncbi Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation
    Fabio Ciceri
    Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 109:4698-707. 2007
  4. doi Chlamydophila psittaci is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: results of a single-center prospective case-control study
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Int J Cancer 123:1089-93. 2008
  5. ncbi Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Natl Cancer Inst 98:1375-82. 2006
  6. doi HS1 has a central role in the trafficking and homing of leukemic B cells
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 116:3537-46. 2010
  7. doi The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma
    Andres J M Ferreri
    Unit of Lymphoid Malignancies and Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milano, Italy
    Br J Haematol 143:253-7. 2008
  8. pmc Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene
    Monica Casucci
    Experimental Hematology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Mol Ther 21:466-75. 2013
  9. doi Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study
    Fabio Ciceri
    Haematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy
    Lancet Oncol 10:489-500. 2009
  10. ncbi Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Clin Oncol 23:5067-73. 2005

Detail Information

Publications91

  1. ncbi Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining
    Maurilio Ponzoni
    Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 17:1513-20. 2004
    ..These findings provide a rationale for the investigational use of anti-CD105-targeted drugs in CIMF...
  2. doi CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
    Monica Casucci
    Leukemia Immunotherapy Group, San Raffaele Scientific Institute, Milan, Italy
    Blood 122:3461-72. 2013
    ..These results warrant the clinical investigation of suicidal CD44v6-targeted T cells in AML and MM. ..
  3. ncbi Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation
    Fabio Ciceri
    Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 109:4698-707. 2007
    ..These data validate the feasibility, safety, and efficacy of TK(+) cells in the context of allografting and represent the basis for a broader application of this technology...
  4. doi Chlamydophila psittaci is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: results of a single-center prospective case-control study
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Int J Cancer 123:1089-93. 2008
    ..Cp infection is common in OAML patients and exceptional in blood donors. Epidemiological data of OAML patients (prolonged contact with household animals and chronic conjunctivitis) are consistent with Cp exposure risk...
  5. ncbi Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Natl Cancer Inst 98:1375-82. 2006
    ..The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested...
  6. doi HS1 has a central role in the trafficking and homing of leukemic B cells
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 116:3537-46. 2010
    ..These findings show that HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in CLL...
  7. doi The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma
    Andres J M Ferreri
    Unit of Lymphoid Malignancies and Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milano, Italy
    Br J Haematol 143:253-7. 2008
    ..50%; P = 0.04), event-free survival (3-year: 89% vs. 35%; P = 0.003) and overall survival (3-year: 89% vs. 38%; P = 0.01). In conclusion, rituximab may substantially change the dismal prognosis of IVL...
  8. pmc Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene
    Monica Casucci
    Experimental Hematology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Mol Ther 21:466-75. 2013
    ..These results warrant the clinical investigation of L-APC-expanded T cells modified with a suicide gene in the setting of haplo-HSCT...
  9. doi Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study
    Fabio Ciceri
    Haematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy
    Lancet Oncol 10:489-500. 2009
    ..We aimed to systematically add back genetically engineered donor lymphocytes to facilitate immune reconstitution and prevent late mortality...
  10. ncbi Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Clin Oncol 23:5067-73. 2005
    ..The present pilot study was carried out to assess whether C psittaci-eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas...
  11. ncbi Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity
    Marco Catucci
    TIGET, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 44:1039-45. 2014
    ..In summary, for the first time, we demonstrate in in vivo models that WASP deficiency affects resistance to tumor and causes impairment in the antitumor capacity of NK cells and DCs. ..
  12. doi Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia
    Elisa ten Hacken
    Division of Molecular Oncology, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Blood 121:2264-73. 2013
    ..Thus LYN/HS1 axis marks distinct signaling profiles and cytoskeletal-related features that may represent valuable targets for cytoskeleton-targeted therapeutic intervention in CLL...
  13. doi High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Lancet 374:1512-20. 2009
    ..We assessed the effect of adding high-dose cytarabine to methotrexate in patients with newly diagnosed primary CNS lymphoma...
  14. ncbi Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Haematologica 92:486-92. 2007
    ..This study explored variations in the clinical manifestations of intravascular lymphoma (IVL) on the bases of the association with hemophagocytosis and the country where the diagnosis was made...
  15. doi Chlamydial infection: the link with ocular adnexal lymphomas
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Nat Rev Clin Oncol 6:658-69. 2009
    ..Available data on the epidemiology, biology and pathogenesis of this association are analyzed and new investigative and clinical approaches are discussed...
  16. pmc A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma
    Maurilio Ponzoni
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 18:876-84. 2013
    ..This review covers the prevalence, clinical presentation, behavior, and histological and molecular features of uncommon forms of primary OAL and provides practical recommendations for therapeutic management. ..
  17. doi Chlamydophila psittaci eradication with doxycycline as first-line targeted therapy for ocular adnexae lymphoma: final results of an international phase II trial
    Andres J M Ferreri
    San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 30:2988-94. 2012
    ..To our knowledge, this is the first international phase II trial aimed at clarifying Cp prevalence and activity of first-line doxycycline in a homogeneous series of consecutive patients with newly diagnosed stage I OAMZL...
  18. ncbi Therapeutic management of ocular adnexal MALT lymphoma
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 6020132, Milan, Italy
    Expert Opin Pharmacother 8:1073-83. 2007
    ..In this review, the authors analyze related literature and propose therapeutic guidelines for the management of ocular adnexal lymphoma of MALT-type...
  19. ncbi Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting
    Maurilio Ponzoni
    Unit of Lymphoma Malignancies, Pathology and Oncology Units, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 25:3168-73. 2007
    ..Finally, a provisional practical diagnostic approach to hemophagocytosis-associated patients and a proposal for the most useful criteria in the settings of differential diagnosis are included...
  20. pmc Autologous pancreatic islet transplantation in human bone marrow
    Paola Maffi
    Islet Transplantation Unit, Diabetes Research Institute, Ospedale San Raffaele, Milan, Italy
    Diabetes 62:3523-31. 2013
    ..Moreover, this is the first unequivocal example of successful engraftment of endocrine tissue in the BM in humans. ..
  21. pmc Prevalence of Borrelia burgdorferi infection in a series of 98 primary cutaneous lymphomas
    Maurilio Ponzoni
    Pathology Unit, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 16:1582-8. 2011
    ..burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients...
  22. ncbi Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: clinical and therapeutic implications
    Andrés Jm Ferreri
    Medical Oncology Unit, San Raffaele H Scientific Institute, Milan, Italy
    Hematol Oncol 24:33-7. 2006
    ....
  23. doi Gastric lymphoma: the histology report
    Claudio Doglioni
    Department of Pathology, Scientific Institute San Raffaele, Milan, Italy
    Dig Liver Dis 43:S310-8. 2011
    ..This paper aims at giving the histopathologist a general knowledge about the state of art of this disease and its management. The diagnostic process leading to a complete and competent report is then described step by step...
  24. ncbi Marginal zone lymphomas and infectious agents
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy Division of Onco Hematological Medicine, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy Electronic address
    Semin Cancer Biol 23:431-40. 2013
    ..Biological and clinical features, therapeutic implications and future perspectives of these lymphoma-microbial associations are discussed in this review. ..
  25. ncbi Immunoreactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation
    Giancarlo Pruneri
    Divisions of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    J Pathol 200:596-601. 2003
    ..000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms...
  26. doi Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Am J Surg Pathol 36:1609-18. 2012
    ..However, presently it is not possible to distinguish SMZL from SDRL on the basis of BMB evaluation alone; hence, histopathologic examination of the spleen remains the "gold standard" approach...
  27. ncbi A virtual tissue bank for primary central nervous system lymphomas in immunocompetent individuals
    Maurilio Ponzoni
    Division of Pathology, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Pathobiology 74:264-9. 2007
    ..ielsg.org. Only anonymous data are centralized at the website of the International Extranodal Lymphoma Study Group, whilst the pathologic material is maintained at the local pathology institutes...
  28. ncbi Mutations of the 5' noncoding region of the BCL-6 gene in primary bone lymphomas
    Umberto Gianelli
    Department of Medicine, Surgery and Dental Sciences, Pathology Unit, University of Milan School of Medicine, A O S Paolo and IRCCS Ospedale Maggiore, Milan, Italy
    Ann Hematol 82:691-5. 2003
    ..The prevalence of mutations was higher in stage I(E) PBL than in more advanced stages of the disease (II(E) + IV) ( p=0.02). Our results reinforce the observation of heterogeneity of the DLBCL included in the clinical category of PBL...
  29. ncbi Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects
    Alessandra Mortellaro
    Via Olgettina 58, 20132, Milan, Italy
    Blood 108:2979-88. 2006
    ..Overall, this study demonstrates the efficacy of LV gene transfer in correcting both the immunological and metabolic phenotypes of ADA-SCID and supports the future clinical use of this approach...
  30. pmc Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models
    Francesco Marangoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Mol Ther 17:1073-82. 2009
    ..Demonstration of long-term efficacy and safety of WAS gene therapy mediated by a clinically applicable LV is a key step toward the implementation of a gene therapy clinical trial for WAS...
  31. doi Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs
    Sara Trifari
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Allergy Clin Immunol 125:439-448.e8. 2010
    ..Secondary mutations leading to re-expression of WAS protein (WASP) are relatively frequent in patients with WAS...
  32. doi Stable knockdown of microRNA in vivo by lentiviral vectors
    Bernhard Gentner
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Nat Methods 6:63-6. 2009
    ..We used bone marrow reconstitution with hematopoietic stem cells stably overexpressing miR-223 target sequence to phenocopy the genetic miR-223 knockout mouse, indicating robust interference of microRNA function in vivo...
  33. doi The role of Helicobacter pylori eradication in the treatment of diffuse large B-cell and marginal zone lymphomas of the stomach
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Curr Opin Oncol 25:470-9. 2013
    ..This review is focused on the effect of Helicobacter pylori eradication with antibiotics in patients with primary gastric lymphomas of indolent and aggressive nature...
  34. ncbi Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Br J Haematol 127:173-83. 2004
    ..ECOG-PS >1, 'cutaneous variant', stage I and chemotherapy use were independently associated with improved survival...
  35. ncbi Ganciclovir is associated with low or undetectable Epstein-Barr virus DNA load in cerebrospinal fluid of patients with HIV-related primary central nervous system lymphoma
    Simona Bossolasco
    Clinic of Infectious Diseases, San Raffaele Hospital, Milan, Italy
    Clin Infect Dis 42:e21-5. 2006
    ..The objective of this study was to assess the effect of ganciclovir on EBV DNA replication in patients with HIV-related PCNSL...
  36. ncbi Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    J Natl Cancer Inst 96:586-94. 2004
    ..Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas...
  37. ncbi Intravascular lymphoma: a neoplasm of 'homeless' lymphocytes?
    Maurilio Ponzoni
    Pathology Unit, San Raffaele H Scientific Institute, Milan, Italy
    Hematol Oncol 24:105-12. 2006
    ..The present review will discuss the most recent acquisitions related either to diagnosis and immunophenotypic/biologic characteristics as well as clinical/therapeutic issues of IVL...
  38. doi A novel Rag2-/-gammac-/--xenograft model of human CLL
    Maria Teresa Sabrina Bertilaccio
    Laboratory of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Blood 115:1605-9. 2010
    ..This model closely resembles aggressive human CLL and could be very useful for evaluating both the biologic basis of CLL growth and dissemination as well as the efficacy of new therapeutic agents...
  39. ncbi Lymphomas of the bone: a pathological and clinical study of 54 cases
    Umberto Gianelli
    Departement of Medicine, Surgery and Dental Sciences, AO S Paolo HSP, Milan, Italy
    Int J Surg Pathol 10:257-66. 2002
    ..This study details the clinical and pathological characteristics of bone lymphomas. Our immunohistochemical and molecular data suggest that most of them are "de novo" DLBCL and support their follicle center origin...
  40. pmc Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
    Kevin Goudy
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Clin Immunol 146:248-61. 2013
    ..Thus, the complex pathogenesis of CD25 deficiency provides invaluable insight into the role of IL2/IL-2RA-dependent regulation in autoimmunity and inflammatory diseases...
  41. ncbi Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Br J Haematol 126:657-64. 2004
    ..If confirmed in prospective trials on PCNSL treated with HD-MTX alone, these data may suggest the necessity for alternative strategies in M-PCNSL considering the increased risk of MTX resistance by tumour cells...
  42. ncbi Chronic lymphocytic leukemia: the pathologist's view of lymph node microenvironment
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, University Scientific Institute San Raffaele, Milan, Italy
    Semin Diagn Pathol 28:161-6. 2011
    ..Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment...
  43. doi Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
    Eduardo J Villablanca
    Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
    Nat Med 16:98-105. 2010
    ..The manipulation of this pathway could restore antitumor immunity in individuals with cancer...
  44. pmc The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
    Eugenio Montini
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Clin Invest 119:964-75. 2009
    ..Our findings strongly support the use of SIN viral vector platforms and show that ISS can substantially modulate genotoxicity...
  45. ncbi Isolated bone marrow manifestation of HIV-associated Hodgkin lymphoma
    Maurilio Ponzoni
    Department of Pathology, S Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 15:1273-8. 2002
    ..A rapid diagnosis of isolated bone marrow HIV-associated Hodgkin lymphoma could expedite therapy...
  46. ncbi Epstein-Barr virus DNA load in cerebrospinal fluid and plasma of patients with AIDS-related lymphoma
    Simona Bossolasco
    Clinic of Infectious Diseases, San Raffaele Hospital, Milan, Italy
    J Neurovirol 8:432-8. 2002
    ..High CSF EBV DNA levels were found in HIV-associated brain lymphomas and the viral load can be clinically useful. High plasma EBV DNA levels might predict CNS involvement in systemic NHL...
  47. ncbi Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    J Clin Oncol 21:266-72. 2003
    ..To identify survival predictors and to design a prognostic score useful for distinguishing risk groups in immunocompetent patients with primary CNS lymphomas (PCNSL)...
  48. pmc Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    PLoS ONE 4:e5959. 2009
    ..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs...
  49. ncbi Extramedullary myeloid cell tumor/granulocytic sarcoma with predilection for serosal surfaces
    Maurilio Ponzoni
    Department of Pathology, Scientific Intitute Ospedale S Raffaele HSR, Milano, Italy
    Haematologica 87:ECR09. 2002
  50. doi Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, Milano, Italy
    Clin Cancer Res 14:5794-800. 2008
    ..Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas...
  51. ncbi Human herpesvirus 8 (HHV-8/KSHV) and hematologic malignancies
    Mauro S Malnati
    Unit of Human Virology DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy
    Rev Clin Exp Hematol 7:375-405. 2003
    ..As seen with KS, the incidence of HHV-8-associated lymphoproliferative disorders is increased in the setting of human immunodeficiency virus infection...
  52. pmc Human herpesvirus 6A accelerates AIDS progression in macaques
    Paolo Lusso
    Unit of Human Virology, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 104:5067-72. 2007
    ..Rapid disease development in dually infected animals was heralded by an early depletion of both CD4(+) and CD8(+) T cells. These results provide in vivo evidence that HHV-6A may act as a promoting factor in AIDS progression...
  53. ncbi Primary stage I-IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients
    Elisabetta Garavaglia
    Division of Gynecology and Obstetrics, University Vita e Salute, S Raffaele Hospital, V Olgettina 60, 20132 Milan, Italy
    Gynecol Oncol 97:214-8. 2005
    ..However, these organs are rarely the site of origin of this type of neoplasia. Because of the rarity of primary genital tract lymphomas, a standard treatment has not been defined...
  54. pmc Clinical relevance of the dose of cytarabine in the upfront treatment of primary CNS lymphomas with methotrexate-cytarabine combination
    Andres J M Ferreri
    Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Oncologist 16:336-41. 2011
    ..With respect to MTX-araC combination, araC dose was halved to minimize toxicity. Herein, we report tolerability, activity, and efficacy of MAT regimen and compare these results to those previously reported with MTX/ara-C combination...
  55. pmc Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Department of Regenerative Medicine, Stem Cells, and Gene Therapy, Milan, Italy
    Haematologica 95:2134-43. 2010
    ..Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for regulatory T-cell-based therapies...
  56. doi Bone marrow as an alternative site for islet transplantation
    Elisa Cantarelli
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Blood 114:4566-74. 2009
    ..The results of our study open a research line with potentially significant clinical impact, not only for the treatment of diabetes, but also for other diseases amenable to treatment with cellular transplantation...
  57. ncbi Prognostic value of bcl-6, CD10 and CD38 immunoreactivity in stage I-II gastric lymphomas: identification of a subset of CD10+ large B-cell lymphomas with a favorable outcome
    Maurilio Ponzoni
    Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
    Int J Cancer 106:288-91. 2003
    ..Accordingly, patients with CD10(+) gastric large B-cell lymphomas may be at reduced risk and eligible for clinical trials evaluating more conservative therapeutic options...
  58. ncbi Cervical thymic hyperplasia after chemotherapy in an adult patient with Hodgkin lymphoma: a potential cause of false-positivity on [18F]FDG PET/CT scanning
    Federico Fallanca
    Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy
    Br J Haematol 140:477. 2008
  59. pmc Ex-vivo dynamic 3-D culture of human tissues in the RCCS™ bioreactor allows the study of Multiple Myeloma biology and response to therapy
    Marina Ferrarini
    Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 8:e71613. 2013
    ..Our findings indicate, as a proof of principle, that 3-D, RCCS™ bioreactor-based culture of tissue explants can be exploited for studying myeloma biology and for a pre-clinical approach to patient-targeted therapy...
  60. doi Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
    Elena Provasi
    Experimental Hematology Unit, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Program of Immunology, Gene Therapy and Bio Immunotherapy of Cancer, Leukemia Unit, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 18:807-15. 2012
    ....
  61. ncbi Isolated bone marrow occurrence of classic Hodgkin's lymphoma in an HIV-negative patient
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milan, Italy
    Haematologica 91:ECR04. 2006
    ..The impacts of such unusual Hodgkin's Lymphoma manifestation on clinical practice as well as the related diagnostic and therapeutic implications are discussed...
  62. ncbi Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    Mary Anna Venneri
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Blood 109:5276-85. 2007
    ..Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy...
  63. ncbi Questions and answers in the management of primary central nervous system and ocular lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Haematologica 88:1063-8. 2003
  64. ncbi Plasma cell granuloma of the thyroid gland: a challenging diagnostic problem
    Anna Cremonini
    San Raffaele Scientific Institute, Milan, Italy
    Int J Surg Pathol 20:500-6. 2012
    ..In view of these considerations, a contemporary diagnostic approach to thyroid plasma cell granuloma is therefore discussed here...
  65. pmc In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
    Greta Maria Paola Giordano Attianese
    Department of Pediatrics, University of Milano Bicocca, Milan, Italy
    Blood 117:4736-45. 2011
    ..CAR(+) T cells resulted in a significant delay in the growth of the MEC-1 CLL cell line. These data suggest that CD23.CAR(+) T cells represent a selective immunotherapy for the elimination of CD23(+) leukemic cells in patients with CLL...
  66. ncbi Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    Eugenio Montini
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132, Milan, Italy
    Nat Biotechnol 24:687-96. 2006
    ..Our results validate a much-needed platform to assess vector safety and provide direct evidence that prototypical lentiviral vectors have low oncogenic potential, highlighting a major rationale for application to gene therapy...
  67. pmc Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers
    Francesca Cottini
    1 Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA 2 Functional Genomics of Cancer Unit, Division of Molecular Oncology, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS San Raffaele Scientific Institute, Milan, Italy
    Nat Med 20:599-606. 2014
    ..Our data therefore identify a new synthetic-lethal strategy to selectively target cancer cells presenting with endogenous DNA damage and low YAP1 levels. ..
  68. ncbi Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes
    Attilio Bondanza
    Experimental Hematology Laboratory, Cancer Immunotherapy and Gene Therapy Program, Università Vita Salute S Raffaele, Pathology Unit, Telethon Institute for Gene Therapy, Milan, Italy
    Blood 107:1828-36. 2006
    ..GCV administration efficiently controlled GvHD induced by CM TK+ lymphocytes. These results warrant the clinical investigation of CM suicide gene-modified human T lymphocytes for safe and effective allo-HCT...
  69. doi Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms
    Roberto Piva
    Department of Pathology, Center for Experimental Research and Medical Studies, Laboratory of Functional Genomics, University of Torino, Torino, Italy
    J Clin Oncol 28:1583-90. 2010
    ....
  70. ncbi Mediastinal follicular dendritic cell sarcoma
    Giovanni Luca Ceresoli
    Department of Radiochemotherapy, San Raffaele Scientific Institute Hospital, Milan, Italy
    Haematologica 88:ECR04. 2003
  71. ncbi Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantation
    Paolo Fiorina
    Department of Medicine I, San Raffaele Hospital, Milan, Italy
    Transplantation 75:1296-301. 2003
    ..The aim of this study was to evaluate the effects of islet transplantation on patient survival and diabetic vascular complications...
  72. ncbi Inherited perforin and Fas mutations in a patient with autoimmune lymphoproliferative syndrome and lymphoma
    Rita Clementi
    Department of Biology and Medical Genetics, University of Pavia, Pavia, Italy
    N Engl J Med 351:1419-24. 2004
    ..The combined effect of the two mutant genes may have contributed to the development of the autoimmune lymphoproliferative syndrome and lymphoma in this patient...
  73. ncbi Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
    Emanuele Zucca
    Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland
    Blood 101:2489-95. 2003
    ..Our data confirm the indolent nature of nongastric MALT lymphomas and the high rate of patients presenting with disseminated disease, which, when limited to mucosal sites, was not associated with a poorer outcome...
  74. ncbi Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients
    Giancarlo Pruneri
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan, School of Medicine, Italy
    Br J Haematol 118:817-20. 2002
    ..01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001)...
  75. ncbi Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial
    Francesco Bertoni
    Department of Experimental Haematology, Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Blood 99:2541-4. 2002
    ..The presence of molecular disease in the absence of histologic disease does not appear to be associated with histologic relapse, but, given the indolent nature of MALT lymphomas, a longer follow-up is needed...
  76. ncbi Clinical activity of rituximab in gastric marginal zone non-Hodgkin's lymphoma resistant to or not eligible for anti-Helicobacter pylori therapy
    Giovanni Martinelli
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    J Clin Oncol 23:1979-83. 2005
    ....
  77. pmc Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano PN Italy
    J Virol 79:2643-9. 2005
    ....
  78. ncbi Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group
    Tamara N Shenkier
    British Columbia Cancer Agency, 600 W 10th Ave, Vancouver, BC, V5Z 4E6, Canada
    J Clin Oncol 23:2233-9. 2005
    ..To describe the demographic and tumor related characteristics and outcomes for patients with primary T-cell CNS lymphoma (TPCNSL)...
  79. doi Variable association between Chlamydophila psittaci infection and ocular adnexal lymphomas: methodological biases or true geographical variations?
    Didier Decaudin
    Department of Clinical Hematology, Institut Curie, Paris, France
    Anticancer Drugs 19:761-5. 2008
    ..psittaci antibodies. This paper also provides some methodological suggestions for future studies in the field of chlamydia-lymphoma associations...
  80. ncbi Rituximab in patients with mucosal-associated lymphoid tissue-type lymphoma of the ocular adnexa
    Andres J M Ferreri
    Haematologica 90:1578-9. 2005
    ..Four responding patients experienced early relapse. The median time to progression was 5 months. The efficacy of rituximab in ocular adnexal lymphoma is lower than that reported for gastric MALT lymphomas...
  81. ncbi Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomas
    Andrea Rinaldi
    Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Br J Haematol 134:27-36. 2006
    ..The combination of DNA copy number and LOH assessment lead to the hypothesis that uniparental disomy may be a potential mechanism in B-cell lymphomagenesis...
  82. ncbi Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesis
    Erich Piovan
    Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Res 67:8605-14. 2007
    ..The unresponsiveness of GC-derived lymphomatous B cells to CXCR4 triggering under hypoxia may have implications for the development and pathogenesis of GC-derived lymphoid tumors...
  83. ncbi A woman and her canary: a tale of chlamydiae and lymphomas
    Andres J M Ferreri
    J Natl Cancer Inst 99:1418-9. 2007
  84. pmc In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia
    Annarita Miccio
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 105:10547-52. 2008
    ..These data provide a rationale for a gene therapy approach to beta-thalassemia based on partially myeloablative transplantation protocols...
  85. ncbi The prevalence and clinical relevance of p27 and cyclin E immunoreactivity in myelodysplastic syndromes
    Giancarlo Pruneri
    Haematologica 88:109-10. 2003
  86. ncbi The cellular origin of mantle cell lymphoma
    Francesco Bertoni
    Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland IOSI, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Int J Biochem Cell Biol 39:1747-53. 2007
    ..In this review will summarize the main morphologic and immunophenotypic features of the neoplastic cells, and the genetics and biology underlying the disease...
  87. ncbi New transcription factors in diagnostic hematopathology
    Maurilio Ponzoni
    Pathology Unit, Scientific Institute San Raffaele, Milano, Italy
    Adv Anat Pathol 14:25-35. 2007
    ..This field is rapidly evolving, as witnessed by the ongoing growing number of novel TFs with possible diagnostic applications appearing in the literature...
  88. ncbi Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type
    Annarita Conconi
    Oncology Institute of Southern Switzerland, Division of Medical Oncology, Bellizona, Switzerland
    Blood 102:2741-5. 2003
    ..001). Most adverse events were of mild to moderate severity with no grade 4 toxicity. This study indicates that rituximab is safe with significant activity in MALT lymphomas...
  89. ncbi Infectious agents in mucosa-associated lymphoid tissue-type lymphomas: pathogenic role and therapeutic perspectives
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
    Clin Lymphoma Myeloma 6:289-300. 2006
    ....
  90. ncbi No association between polyomaviruses and primary central nervous system lymphomas of HIV-seronegative and HIV-positive patients
    Fernanda Martini
    Department of Morphology and Embryology, School of Medicine, University of Ferrara, Via Fossato di Mortara, 64 B, 44100 Ferrara, Italy
    Cancer Epidemiol Biomarkers Prev 13:1819-20. 2004
  91. doi Can rituximab change the usually dismal prognosis of patients with intravascular large B-cell lymphoma?
    Andres J M Ferreri
    J Clin Oncol 26:5134-6; author reply 5136-7. 2008