Stefano Mora

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Longitudinal changes of bone mineral density and metabolism in antiretroviral-treated human immunodeficiency virus-infected children
    Stefano Mora
    Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Milan, 20132 Italy
    J Clin Endocrinol Metab 89:24-8. 2004
  2. ncbi request reprint Pediatric HIV infection and bone health: an emerging challenge
    Stefano Mora
    Laboratory of Pediatric Endocrinology and BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Front Biosci (Elite Ed) 2:1265-74. 2010
  3. doi request reprint Antiretroviral therapy and pregnancy: effect on cortical bone status of human immunodeficiency virus-infected Caucasian women as assessed by quantitative ultrasonography
    Stefano Mora
    Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Calcif Tissue Int 92:394-8. 2013
  4. pmc Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity
    Johanna Korvala
    Oulu Center for Cell Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    BMC Med Genet 13:26. 2012
  5. doi request reprint Exposure to antiretroviral agents during pregnancy does not alter bone status in infants
    Stefano Mora
    Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Bone 50:255-8. 2012
  6. ncbi request reprint Bone mass and bone metabolism in pediatric gastrointestinal disorders
    Stefano Mora
    Laboratory of Pediatric Endocrinology, H San Raffaele, Milano, Italy
    J Pediatr Gastroenterol Nutr 39:129-40. 2004
  7. doi request reprint Differential effect of age, gender and puberty on bone formation rate assessed by measurement of bone-specific alkaline phosphatase in healthy Italian children and adolescents
    Stefano Mora
    Laboratory of Pediatric Endocrinology, BoNetwork, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Bone Miner Metab 27:721-6. 2009
  8. doi request reprint Celiac disease in children: impact on bone health
    Stefano Mora
    Laboratory of Pediatric Endocrinology and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
    Rev Endocr Metab Disord 9:123-30. 2008
  9. doi request reprint Applicability of quantitative ultrasonography of the radius and tibia in HIV-infected children and adolescents
    Stefano Mora
    Laboratory of Pediatric Endocrinology, Pediatric Bone Densitometry Service and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
    J Acquir Immune Defic Syndr 51:588-92. 2009
  10. ncbi request reprint Alterations in circulating osteoimmune factors may be responsible for high bone resorption rate in HIV-infected children and adolescents
    Stefano Mora
    Laboratory of Pediatric Endocrinology and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
    AIDS 21:1129-35. 2007

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Longitudinal changes of bone mineral density and metabolism in antiretroviral-treated human immunodeficiency virus-infected children
    Stefano Mora
    Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Milan, 20132 Italy
    J Clin Endocrinol Metab 89:24-8. 2004
    ..Our data confirm the presence of low BMD and bone metabolism derangement in HIV-infected children treated with HAART. The role of possible therapeutic approach to restore bone mass and metabolism should be assessed in pediatrics...
  2. ncbi request reprint Pediatric HIV infection and bone health: an emerging challenge
    Stefano Mora
    Laboratory of Pediatric Endocrinology and BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Front Biosci (Elite Ed) 2:1265-74. 2010
    ..Preventative measures to improve bone health are thus necessary in all young patients that exhibit low bone mass measurements and altered bone metabolism...
  3. doi request reprint Antiretroviral therapy and pregnancy: effect on cortical bone status of human immunodeficiency virus-infected Caucasian women as assessed by quantitative ultrasonography
    Stefano Mora
    Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Calcif Tissue Int 92:394-8. 2013
    ..69). No significant differences were observed between ARV-exposed and control subjects at 4 and 12 months. Our data suggest that ARV during pregnancy and the first year after delivery does not affect negatively cortical bone status...
  4. pmc Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity
    Johanna Korvala
    Oulu Center for Cell Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    BMC Med Genet 13:26. 2012
    ..We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lipoprotein receptor-related protein 5 (LRP5) gene, and the role of LRP5 is further investigated here...
  5. doi request reprint Exposure to antiretroviral agents during pregnancy does not alter bone status in infants
    Stefano Mora
    Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Bone 50:255-8. 2012
    ....
  6. ncbi request reprint Bone mass and bone metabolism in pediatric gastrointestinal disorders
    Stefano Mora
    Laboratory of Pediatric Endocrinology, H San Raffaele, Milano, Italy
    J Pediatr Gastroenterol Nutr 39:129-40. 2004
  7. doi request reprint Differential effect of age, gender and puberty on bone formation rate assessed by measurement of bone-specific alkaline phosphatase in healthy Italian children and adolescents
    Stefano Mora
    Laboratory of Pediatric Endocrinology, BoNetwork, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Bone Miner Metab 27:721-6. 2009
    ..Because BAP concentrations vary markedly according to the pubertal stage, the values of BAP obtained in single patients should be compared to reference considering not only age and sex, but also the stage of pubertal development...
  8. doi request reprint Celiac disease in children: impact on bone health
    Stefano Mora
    Laboratory of Pediatric Endocrinology and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
    Rev Endocr Metab Disord 9:123-30. 2008
    ..Monitoring of dietary compliance is important to ensure appropriate bone mass accrual through childhood and puberty in these patients, to maximize peak bone mass and reduce fracture risk later in life...
  9. doi request reprint Applicability of quantitative ultrasonography of the radius and tibia in HIV-infected children and adolescents
    Stefano Mora
    Laboratory of Pediatric Endocrinology, Pediatric Bone Densitometry Service and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
    J Acquir Immune Defic Syndr 51:588-92. 2009
    ..To assess applicability of quantitative ultrasonography (QUS) for bone health assessment in HIV-infected youths...
  10. ncbi request reprint Alterations in circulating osteoimmune factors may be responsible for high bone resorption rate in HIV-infected children and adolescents
    Stefano Mora
    Laboratory of Pediatric Endocrinology and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
    AIDS 21:1129-35. 2007
    ..We investigated the possible role of RANKL and osteoprotegerin on bone metabolism alterations in paediatric patients...
  11. ncbi request reprint Lipodystrophy, insulin resistance, and adiponectin concentration in HIV-infected children and adolescents
    Alessandra Vigano
    Pediatric Infectious Diseases Unit, Department of Pediatrics, L Sacco Hospital, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    Curr HIV Res 9:321-6. 2011
    ..Strict monitoring of metabolic and cardiovascular evolution should be performed in these patients...
  12. ncbi request reprint Analysis of bone mineral content in horizontally HIV-infected children naïve to antiretroviral treatment
    S Mora
    Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Via Olgeltina 60, Milan, Italy
    Calcif Tissue Int 76:336-40. 2005
    ..The duration of HIV infection did not relate to BMC values. In conclusion, horizontally HIV-infected children naïve to antiretroviral therapy have bone mineral measurements comparable to those of healthy children...
  13. doi request reprint Tenofovir disoproxil fumarate and bone mineral density: a 60-month longitudinal study in a cohort of HIV-infected youths
    Alessandra Vigano
    Pediatric Infectious Diseases Unit, Department of Pediatrics, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 15:1053-8. 2010
    ..The aim of this study was to assess the safety of a TDF-containing antiretroviral (ARV) regimen on BMD in paediatric patients. We report the results of a longitudinal 60-month follow-up study...
  14. doi request reprint In utero exposure to tenofovir disoproxil fumarate does not impair growth and bone health in HIV-uninfected children born to HIV-infected mothers
    Alessandra Vigano
    Department of Paediatrics, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 16:1259-66. 2011
    ..We evaluated growth pattern and bone health in TDF-exposed HIV-uninfected children born to HIV-infected mothers, defined as seroreverters (SR)...
  15. doi request reprint Antiretroviral therapy and bone mineral measurements in HIV-infected youths
    Gianvincenzo Zuccotti
    Department of Pediatrics, L Sacco Hospital, University of Milan, Milan, Italy
    Bone 46:1633-8. 2010
    ..The use of antiretroviral regimens including these drugs should thus be monitored closely in HIV-infected youths...
  16. ncbi request reprint Reduced bone mineral density and increased bone metabolism rate in young adult patients with 21-hydroxylase deficiency
    Mariateresa Sciannamblo
    Laboratory of Pediatric Endocrinology and Department of Pediatrics, San Raffaele Scientific Institute, Vita Salute S Raffaele University, Milan, Italy
    J Clin Endocrinol Metab 91:4453-8. 2006
    ..Patients with congenital adrenal hyperplasia (CAH) receive glucocorticoids as replacement therapy. Glucocorticoid therapy is the most frequent cause of drug-induced osteoporosis...
  17. ncbi request reprint A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected children
    Vania Giacomet
    Department of Pediatrics, L Sacco Hospital, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 40:448-50. 2005
    ..Short-term use of tenofovir (TDF) has been associated with bone mineral loss in adults and children...
  18. doi request reprint Genetic analysis of Italian patients with congenital hyperinsulinism of infancy
    Paola Sogno Valin
    Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy
    Horm Res Paediatr 79:236-42. 2013
    ..Congenital hyperinsulinism of infancy is a rare disease that needs prompt treatment to avoid brain damage. There are currently no data regarding the clinical and molecular features of Italian patients...
  19. ncbi request reprint Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet
    Graziano Barera
    Department of Pediatrics, Scientific Institute H San Raffaele, Milan, Italy
    Am J Clin Nutr 79:148-54. 2004
    ..A gluten-free diet (GFD) rapidly corrects the bone mineral deficit of children with untreated celiac disease. The mechanisms underlying such changes are still poorly understood...
  20. doi request reprint Long-term body composition and metabolic changes in HIV-infected children switched from stavudine to tenofovir and from protease inhibitors to efavirenz
    Valentina Fabiano
    Department of Pediatrics, University of Milan, L Sacco Hospital, Milan, Italy
    Eur J Pediatr 172:1089-96. 2013
    ..Conclusions: patients, after switching from d4T to TDF and from PI to EFV, show most of the changes in anthropometry and body composition associated with normal growth and no frankly pathological change in metabolic parameters...
  21. pmc Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism
    Maria Carla Proverbio
    Dipartimento di Fisiopatologia e dei Trapianti DePT, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 8:e68740. 2013
    ....
  22. ncbi request reprint Adverse effects of antiretroviral therapy: focus on bone density
    Alessandra Vigano
    Clinica Pediatrica, Ospedale L Sacco, Milan, Italy
    Expert Opin Drug Saf 3:199-208. 2004
    ....
  23. doi request reprint Cholecalciferol supplementation in HIV-infected youth with vitamin D insufficiency: effects on vitamin D status and T-cell phenotype: a randomized controlled trial
    Vania Giacomet
    Department of Paediatrics, Luigi Sacco Hospital Università degli Studi di Milano, Milan, Italy
    HIV Clin Trials 14:51-60. 2013
    ..Design: We performed a randomized controlled trial (RCT) to test whether cholecalciferol supplementation can improve vitamin D status and affect the T-cell phenotype in HIV-infected youth with vitamin D insufficiency...
  24. doi request reprint Regional fat distribution in children born preterm evaluated at school age
    Maria L Giannì
    Neonatal Intensive Care Unit, Institute of Pediatrics and Neonatology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena University Medical School, Milan, Italy
    J Pediatr Gastroenterol Nutr 46:232-5. 2008
    ..Fat mass indexes in the limbs but not the trunk were lower in children born preterm than in children born at term. In conclusion, children born preterm, evaluated at school age, may be at risk for altered regional adiposity...
  25. doi request reprint Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene
    Stefania Di Candia
    Department of Pediatrics, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
    Eur J Endocrinol 160:1019-23. 2009
    ....
  26. ncbi request reprint Polymorphism of vitamin D receptor gene start codon in patients with calcium kidney stones
    Giuseppe Vezzoli
    Division of Nephrology Dialysis and Hypertension, San Raffaele Scientific Institute, Milan, Italy
    J Nephrol 15:158-64. 2002
    ..In order to assess the eventual role of VDR gene start codon polymorphisms in stone production, we analyzed the genotype-phenotype association in a group of patients with calcium kidney stones...
  27. ncbi request reprint Impaired growth hormone secretion correlates with visceral adiposity in highly active antiretroviral treated HIV-infected adolescents
    Alessandra Vigano
    L Sacco Hospital, University of Milan, IRCCS H S Raffaele, Milan, Italy
    AIDS 17:1435-41. 2003
    ..HIV-infected adults with lipodystrophy, characterized by excess accumulation of intra-abdominal adipose tissue (IAT), showed impaired growth hormone (GH) secretion. Data are lacking in paediatric lipodystrophy with the same features...
  28. ncbi request reprint Establishment of peak bone mass
    Stefano Mora
    Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Milan, Italy
    Endocrinol Metab Clin North Am 32:39-63. 2003
    ....
  29. ncbi request reprint [Comparative study of the short-term effect of mineral water on calcium metabolism]
    Giuseppe Vezzoli
    Unita di Nefrologia e Dialisi, Istituto Scientifico San Raffaele, Milano, Italy
    G Ital Nefrol 27:391-5. 2010
    ..Drinking Sangemini water may have a slight effect on calcium excretion and may not inhibit bone turnover in the short term. The lesser effect of Sangemini water on calcium excretion could be useful in the treatment of osteoporosis...
  30. ncbi request reprint Vitamin D receptor mRNA measured in leukocytes with the TaqMan fluorogenic detection system: effect of calcitriol administration
    Laura Soldati
    Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
    Clin Chem 50:1315-21. 2004
    ..The aim of the present study was to investigate the interactions between the circulating concentrations of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and the mRNA concentration of its specific nuclear receptor in human leukocytes...
  31. pmc IgA anti-actin antibodies in children with celiac disease: comparison of immunofluorescence with Elisa assay in predicting severe intestinal damage
    Elena Bazzigaluppi
    Department of Pediatrics, San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy
    Ital J Pediatr 36:25. 2010
    ....
  32. pmc Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism
    Ilaria Zamproni
    Laboratory of Pediatric Endocrinology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    J Clin Endocrinol Metab 93:605-10. 2008
    ..DUOX2 deficiency produces congenital hypothyroidism (CH) in humans and mice. We recently cloned a novel gene, the product of which (dual oxidase maturation factor 2; DUOXA2) is required to express DUOX2 enzymatic activity...
  33. ncbi request reprint A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease
    S Mora
    Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, University of Milan, Milan, Italy
    J Pediatr 139:516-21. 2001
    ..CONCLUSIONS: This study shows that bone mineral content, bone area, and bone mineral density improve significantly with a GFD...
  34. ncbi request reprint Bone mineral loss through increased bone turnover in HIV-infected children treated with highly active antiretroviral therapy
    S Mora
    Laboratory of Pediatric Endocrinology, Department of Pediatrics, Scientific Institute H. S. Raffaele, Italy
    AIDS 15:1823-9. 2001
    ..041) children. CONCLUSIONS: HAART seems a new risk factor for life-long osteoporosis in children. An increased rate of bone turnover causes BMD decrease. Severity of osteopenia seems to be related to lipodystrophy...
  35. ncbi request reprint Autosomal dominant hypocalcemia with mild type 5 Bartter syndrome
    Giuseppe Vezzoli
    Nephrology and Dialysis Unit, IRCCS San Raffaele Hospital, Vita Salute University, Milan, Italy
    J Nephrol 19:525-8. 2006
    ..However, the phenotype of type 5 Bartter syndrome may manifest with variable severity, not directly related with the in vitro potency of the CaSR activating mutation...
  36. ncbi request reprint Validation of food frequency questionnaire for assessing dietary macronutrients and calcium intake in Italian children and adolescents
    Simona Bertoli
    International Centre for the Assessment of Nutritional Status, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 40:555-60. 2005
    ..To validate a food frequency questionnaire to determine calcium and macronutrient intake in healthy children and adolescents...
  37. ncbi request reprint Renal safety of tenofovir in HIV-infected children: a prospective, 96-week longitudinal study
    A Vigano
    Clinic of Paediatrics, L Sacco Hospital, University of Milan, Milan, Italy
    Clin Drug Investig 27:573-81. 2007
    ..The aims of this study were to assess renal safety and GFR changes as estimated by the Schwartz and Cockcroft-Gault equations in HIV-infected children treated with tenofovir for 96 weeks...
  38. ncbi request reprint Normalization of fat accrual in lipoatrophic, HIV-infected children switched from stavudine to tenofovir and from protease inhibitor to efavirenz
    Alessandro Viganò
    Department of Paediatrics, L Sacco Hospital, University of Milan, Italy
    Antivir Ther 12:297-302. 2007
    ..We assess the effect on body composition parameters of replacing stavudine with tenofovir and protease inhibitor with efavirenz in paediatric patients...
  39. ncbi request reprint Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected children
    Alessandra Vigano
    L Sacco Hospital, University of Milan, Italy
    Antivir Ther 10:917-24. 2005
    ..To assess the impact on immunological, virological and metabolic parameters of replacing protease inhibitors (PIs) with efavirenz and replacing stavudine with tenofovir in HIV-infected children...
  40. ncbi request reprint Increased lipodystrophy is associated with increased exposure to highly active antiretroviral therapy in HIV-infected children
    Alessandra Vigano
    Department of Pediatrics, L Sacco Hospital, Via GB Grassi 74, 20157 Milan, Italy
    J Acquir Immune Defic Syndr 32:482-9. 2003
    ..To assess body composition changes in HIV-infected children receiving highly active antiretroviral therapy (HAART)...
  41. ncbi request reprint Postnatal "speed of sound" decline in preterm infants: an exploratory study
    Paola Roggero
    Neonatal Intensive Care Unit, Institute of Pediatrics and Neonatology, University Medical School, Via Commenda 12, 20122 Milano, Italy
    J Pediatr Gastroenterol Nutr 45:615-7. 2007
    ..Body fat mass increased significantly. No correlation between SOS and body fat mass was found. SOS was not influenced by changes in body fat mass. The decline in SOS may be ascribed to bone structure factors...
  42. ncbi request reprint Celiac disease: a bone perspective
    Stefano Mora
    J Pediatr Gastroenterol Nutr 37:409-11. 2003
  43. ncbi request reprint Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor
    Jianxin Hu
    Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bone Miner Res 19:578-86. 2004
    ..Additional mutagenesis studies lead us to speculate concerning a novel mechanism whereby the K29E mutation may lead to receptor activation...
  44. ncbi request reprint Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domain
    Jianxin Hu
    Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bone Miner Res 17:1461-9. 2002
    ..We present a hypothesis to explain receptor activation by mutations in this region based on the recently described three-dimensional structure of the related metabotropic glutamate type 1 receptor (mGluR1)...
  45. ncbi request reprint Effects of recombinant growth hormone on visceral fat accumulation: pilot study in human immunodeficiency virus-infected adolescents
    Alessandra Vigano
    Department of Paediatrics, L Sacco Hospital, University of Milan, Italy
    J Clin Endocrinol Metab 90:4075-80. 2005
    ..Recombinant human GH (rhGH) reduces excess accumulation of intraabdominal adipose tissue (IAT) in lipodystrophic HIV-infected adults, whereas data in pediatric patients are lacking...
  46. ncbi request reprint A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+
    Jianxin Hu
    Molecular Pathophysiology Section, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:5113-20. 2005
    ..The implications of our finding that NPS 2143 corrects the molecular defect of ADH mutations for treatment of this disease are also discussed...
  47. ncbi request reprint Severe hypocalcemia due to a de novo mutation in the fifth transmembrane domain of the calcium-sensing receptor
    Stefano Mora
    Am J Med Genet A 140:98-101. 2006
  48. ncbi request reprint Relationship of sex hormones to bone geometric properties and mineral density in early pubertal girls: use of correlation analyses
    Stefano Mora
    J Clin Endocrinol Metab 89:5866; author reply 5866. 2004