Research Topics
Species | Stefano MoraSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Detail Information
Publications
Longitudinal changes of bone mineral density and metabolism in antiretroviral-treated human immunodeficiency virus-infected childrenStefano Mora
Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Milan, 20132 Italy
J Clin Endocrinol Metab 89:24-8. 2004..Our data confirm the presence of low BMD and bone metabolism derangement in HIV-infected children treated with HAART. The role of possible therapeutic approach to restore bone mass and metabolism should be assessed in pediatrics...- Pediatric HIV infection and bone health: an emerging challengeStefano Mora
Laboratory of Pediatric Endocrinology and BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Front Biosci (Elite Ed) 2:1265-74. 2010..Preventative measures to improve bone health are thus necessary in all young patients that exhibit low bone mass measurements and altered bone metabolism... 
Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activityJohanna Korvala
Oulu Center for Cell Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
BMC Med Genet 13:26. 2012..We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lipoprotein receptor-related protein 5 (LRP5) gene, and the role of LRP5 is further investigated here...
Exposure to antiretroviral agents during pregnancy does not alter bone status in infantsStefano Mora
Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Bone 50:255-8. 2012....- Bone mass and bone metabolism in pediatric gastrointestinal disordersStefano Mora
Laboratory of Pediatric Endocrinology, H. San Raffaele, Milano, Italy
J Pediatr Gastroenterol Nutr 39:129-40. 2004 - Applicability of quantitative ultrasonography of the radius and tibia in HIV-infected children and adolescentsStefano Mora
Laboratory of Pediatric Endocrinology, Pediatric Bone Densitometry Service and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
J Acquir Immune Defic Syndr 51:588-92. 2009..To assess applicability of quantitative ultrasonography (QUS) for bone health assessment in HIV-infected youths... - Celiac disease in children: impact on bone healthStefano Mora
Laboratory of Pediatric Endocrinology and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
Rev Endocr Metab Disord 9:123-30. 2008..Monitoring of dietary compliance is important to ensure appropriate bone mass accrual through childhood and puberty in these patients, to maximize peak bone mass and reduce fracture risk later in life... - Lipodystrophy, insulin resistance, and adiponectin concentration in HIV-infected children and adolescentsAlessandra Vigano
Pediatric Infectious Diseases Unit, Department of Pediatrics, L Sacco Hospital, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
Curr HIV Res 9:321-6. 2011..Strict monitoring of metabolic and cardiovascular evolution should be performed in these patients... - Analysis of bone mineral content in horizontally HIV-infected children naïve to antiretroviral treatmentS Mora
Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Via Olgeltina 60, Milan, Italy
Calcif Tissue Int 76:336-40. 2005..The duration of HIV infection did not relate to BMC values. In conclusion, horizontally HIV-infected children naïve to antiretroviral therapy have bone mineral measurements comparable to those of healthy children... - Differential effect of age, gender and puberty on bone formation rate assessed by measurement of bone-specific alkaline phosphatase in healthy Italian children and adolescentsStefano Mora
Laboratory of Pediatric Endocrinology, BoNetwork, San Raffaele Scientific Institute, 20132 Milan, Italy
J Bone Miner Metab 27:721-6. 2009..Because BAP concentrations vary markedly according to the pubertal stage, the values of BAP obtained in single patients should be compared to reference considering not only age and sex, but also the stage of pubertal development... - Alterations in circulating osteoimmune factors may be responsible for high bone resorption rate in HIV-infected children and adolescentsStefano Mora
Laboratory of Pediatric Endocrinology and BoNetwork, San Raffaele Scientific Institute, Milan, Italy
AIDS 21:1129-35. 2007..We investigated the possible role of RANKL and osteoprotegerin on bone metabolism alterations in paediatric patients... - In utero exposure to tenofovir disoproxil fumarate does not impair growth and bone health in HIV-uninfected children born to HIV-infected mothersAlessandra Vigano
Department of Paediatrics, L Sacco Hospital, University of Milan, Milan, Italy
Antivir Ther 16:1259-66. 2011..We evaluated growth pattern and bone health in TDF-exposed HIV-uninfected children born to HIV-infected mothers, defined as seroreverters (SR)... - Tenofovir disoproxil fumarate and bone mineral density: a 60-month longitudinal study in a cohort of HIV-infected youthsAlessandra Vigano
Pediatric Infectious Diseases Unit, Department of Pediatrics, L Sacco Hospital, University of Milan, Milan, Italy
Antivir Ther 15:1053-8. 2010..The aim of this study was to assess the safety of a TDF-containing antiretroviral (ARV) regimen on BMD in paediatric patients. We report the results of a longitudinal 60-month follow-up study... - Antiretroviral therapy and bone mineral measurements in HIV-infected youthsGianvincenzo Zuccotti
Department of Pediatrics, L Sacco Hospital, University of Milan, Milan, Italy
Bone 46:1633-8. 2010..The use of antiretroviral regimens including these drugs should thus be monitored closely in HIV-infected youths... - Reduced bone mineral density and increased bone metabolism rate in young adult patients with 21-hydroxylase deficiencyMariateresa Sciannamblo
Laboratory of Pediatric Endocrinology and Department of Pediatrics, San Raffaele Scientific Institute, Vita-Salute S. Raffaele University, Milan, Italy
J Clin Endocrinol Metab 91:4453-8. 2006..CONCLUSIONS: Young adult patients with the classical form of CAH have decreased bone density values, compared with healthy controls. This may put them at risk of developing osteoporosis early in life... - A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected childrenVania Giacomet
Department of Pediatrics, L. Sacco Hospital, University of Milan, Milan, Italy
J Acquir Immune Defic Syndr 40:448-50. 2005..CONCLUSIONS: Substitution to a TDF-containing antiretroviral regimen does not seem to impair bone mineral accrual in children showing a good immunologic response to antiretroviral treatment... - Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free dietGraziano Barera
Department of Pediatrics, Scientific Institute H San Raffaele, Milan, Italy
Am J Clin Nutr 79:148-54. 2004..Remarkable changes occur after the initiation of a GFD, and they result in a more balanced equilibrium... - Adverse effects of antiretroviral therapy: focus on bone densityAlessandra Vigano
Clinica Pediatrica, Ospedale L Sacco, Milan, Italy
Expert Opin Drug Saf 3:199-208. 2004.... - Regional fat distribution in children born preterm evaluated at school ageMaria L Giannì
Neonatal Intensive Care Unit, Institute of Pediatrics and Neonatology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena University Medical School, Milan, Italy
J Pediatr Gastroenterol Nutr 46:232-5. 2008..Fat mass indexes in the limbs but not the trunk were lower in children born preterm than in children born at term. In conclusion, children born preterm, evaluated at school age, may be at risk for altered regional adiposity... - Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH geneStefania Di Candia
Department of Pediatrics, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
Eur J Endocrinol 160:1019-23. 2009.... - Polymorphism of vitamin D receptor gene start codon in patients with calcium kidney stonesGiuseppe Vezzoli
Division of Nephrology Dialysis and Hypertension, San Raffaele Scientific Institute, Milan, Italy
J Nephrol 15:158-64. 2002..In order to assess the eventual role of VDR gene start codon polymorphisms in stone production, we analyzed the genotype-phenotype association in a group of patients with calcium kidney stones... - Impaired growth hormone secretion correlates with visceral adiposity in highly active antiretroviral treated HIV-infected adolescentsAlessandra Vigano
L Sacco Hospital, University of Milan, IRCCS H S Raffaele, Milan, Italy
AIDS 17:1435-41. 2003..HIV-infected adults with lipodystrophy, characterized by excess accumulation of intra-abdominal adipose tissue (IAT), showed impaired growth hormone (GH) secretion. Data are lacking in paediatric lipodystrophy with the same features... - Establishment of peak bone massStefano Mora
Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Milan, Italy
Endocrinol Metab Clin North Am 32:39-63. 2003.... - [Comparative study of the short-term effect of mineral water on calcium metabolism]Giuseppe Vezzoli
Unita di Nefrologia e Dialisi, Istituto Scientifico San Raffaele, Milano, Italy
G Ital Nefrol 27:391-5. 2010..Drinking Sangemini water may have a slight effect on calcium excretion and may not inhibit bone turnover in the short term. The lesser effect of Sangemini water on calcium excretion could be useful in the treatment of osteoporosis... - Vitamin D receptor mRNA measured in leukocytes with the TaqMan fluorogenic detection system: effect of calcitriol administrationLaura Soldati
Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
Clin Chem 50:1315-21. 2004..The aim of the present study was to investigate the interactions between the circulating concentrations of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and the mRNA concentration of its specific nuclear receptor in human leukocytes... - IgA anti-actin antibodies in children with celiac disease: comparison of immunofluorescence with Elisa assay in predicting severe intestinal damageElena Bazzigaluppi
Department of Pediatrics, San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy
Ital J Pediatr 36:25. 2010.... - Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidismIlaria Zamproni
Laboratory of Pediatric Endocrinology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
J Clin Endocrinol Metab 93:605-10. 2008..DUOX2 deficiency produces congenital hypothyroidism (CH) in humans and mice. We recently cloned a novel gene, the product of which (dual oxidase maturation factor 2; DUOXA2) is required to express DUOX2 enzymatic activity... - A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac diseaseS Mora
Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, University of Milan, Milan, Italy
J Pediatr 139:516-21. 2001..CONCLUSIONS: This study shows that bone mineral content, bone area, and bone mineral density improve significantly with a GFD... - Bone mineral loss through increased bone turnover in HIV-infected children treated with highly active antiretroviral therapyS Mora
Laboratory of Pediatric Endocrinology, Department of Pediatrics, Scientific Institute H. S. Raffaele, Italy
AIDS 15:1823-9. 2001..041) children. CONCLUSIONS: HAART seems a new risk factor for life-long osteoporosis in children. An increased rate of bone turnover causes BMD decrease. Severity of osteopenia seems to be related to lipodystrophy... - Autosomal dominant hypocalcemia with mild type 5 Bartter syndromeGiuseppe Vezzoli
Nephrology and Dialysis Unit, IRCCS San Raffaele Hospital, Vita Salute University, Milan, Italy
J Nephrol 19:525-8. 2006..However, the phenotype of type 5 Bartter syndrome may manifest with variable severity, not directly related with the in vitro potency of the CaSR activating mutation... - Validation of food frequency questionnaire for assessing dietary macronutrients and calcium intake in Italian children and adolescentsSimona Bertoli
International Centre for the Assessment of Nutritional Status, University of Milan, Milan, Italy
J Pediatr Gastroenterol Nutr 40:555-60. 2005..The ranking of subjects is extremely useful for epidemiologic studies evaluating the relation between nutrient intake and disease... - Renal safety of tenofovir in HIV-infected children: a prospective, 96-week longitudinal studyA Vigano
Clinic of Paediatrics, L Sacco Hospital, University of Milan, Milan, Italy
Clin Drug Investig 27:573-81. 2007..The aims of this study were to assess renal safety and GFR changes as estimated by the Schwartz and Cockcroft-Gault equations in HIV-infected children treated with tenofovir for 96 weeks... - Increased lipodystrophy is associated with increased exposure to highly active antiretroviral therapy in HIV-infected childrenAlessandra Vigano
Department of Pediatrics, L Sacco Hospital, Via GB Grassi 74, 20157 Milan, Italy
J Acquir Immune Defic Syndr 32:482-9. 2003..To assess body composition changes in HIV-infected children receiving highly active antiretroviral therapy (HAART)... - Celiac disease: a bone perspectiveStefano Mora
J Pediatr Gastroenterol Nutr 37:409-11. 2003 - Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptorJianxin Hu
Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Bone Miner Res 19:578-86. 2004..Additional mutagenesis studies lead us to speculate concerning a novel mechanism whereby the K29E mutation may lead to receptor activation... - Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected childrenAlessandra Vigano
L Sacco Hospital, University of Milan, Italy
Antivir Ther 10:917-24. 2005..To assess the impact on immunological, virological and metabolic parameters of replacing protease inhibitors (PIs) with efavirenz and replacing stavudine with tenofovir in HIV-infected children... - Postnatal "speed of sound" decline in preterm infants: an exploratory studyPaola Roggero
Neonatal Intensive Care Unit, Institute of Pediatrics and Neonatology, University Medical School, Via Commenda 12, 20122 Milano, Italy
J Pediatr Gastroenterol Nutr 45:615-7. 2007..Body fat mass increased significantly. No correlation between SOS and body fat mass was found. SOS was not influenced by changes in body fat mass. The decline in SOS may be ascribed to bone structure factors... - Normalization of fat accrual in lipoatrophic, HIV-infected children switched from stavudine to tenofovir and from protease inhibitor to efavirenzAlessandro Viganò
Department of Paediatrics, L Sacco Hospital, University of Milan, Italy
Antivir Ther 12:297-302. 2007..We assess the effect on body composition parameters of replacing stavudine with tenofovir and protease inhibitor with efavirenz in paediatric patients... - Relationship of sex hormones to bone geometric properties and mineral density in early pubertal girls: use of correlation analysesStefano Mora
J Clin Endocrinol Metab 89:5866; author reply 5866. 2004 - Severe hypocalcemia due to a de novo mutation in the fifth transmembrane domain of the calcium-sensing receptorStefano Mora
Am J Med Genet A 140:98-101. 2006 - Effects of recombinant growth hormone on visceral fat accumulation: pilot study in human immunodeficiency virus-infected adolescentsAlessandra Vigano
Department of Paediatrics, L Sacco Hospital, University of Milan, Italy
J Clin Endocrinol Metab 90:4075-80. 2005..Recombinant human GH (rhGH) reduces excess accumulation of intraabdominal adipose tissue (IAT) in lipodystrophic HIV-infected adults, whereas data in pediatric patients are lacking... - Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domainJianxin Hu
Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Bone Miner Res 17:1461-9. 2002..We present a hypothesis to explain receptor activation by mutations in this region based on the recently described three-dimensional structure of the related metabotropic glutamate type 1 receptor (mGluR1)... - A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+Jianxin Hu
Molecular Pathophysiology Section, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:5113-20. 2005..The implications of our finding that NPS 2143 corrects the molecular defect of ADH mutations for treatment of this disease are also discussed...