Gianluigi Mazzoccoli

Summary

Affiliation: San Giovanni Rotondo
Country: Italy

Publications

  1. doi request reprint The circadian clock and the hypoxic response pathway in kidney cancer
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Cappuccini Avenue, San Giovanni Rotondo, FG, 71013, Italy
    Tumour Biol 35:1-7. 2014
  2. doi request reprint Caloric restriction and aging stem cells: the stick and the carrot?
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo, FG, Italy Electronic address
    Exp Gerontol 50:137-48. 2014
  3. pmc Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S, Giovanni Rotondo FG, Italy
    BMC Med Genomics 6:37. 2013
  4. doi request reprint Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Chronobiol Int 29:1300-11. 2012
  5. ncbi request reprint Hormone and cytokine circadian alteration in non-small cell lung cancer patients
    G Mazzoccoli
    Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Int J Immunopathol Pharmacol 25:691-702. 2012
  6. doi request reprint Association study of a polymorphism in clock gene PERIOD3 and risk of inflammatory bowel disease
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Chronobiol Int 29:994-1003. 2012
  7. ncbi request reprint REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge
    G Mazzoccoli
    Department of Medical Sciences, Scientific Institute and Regional General Hospital, Casa Sollievo della Sofferenza, Italy
    J Biol Regul Homeost Agents 26:265-76. 2012
  8. ncbi request reprint Concomitant evaluation of flow-mediated vasodilation and epicardial fat thickness in idiopathic deep venous thrombosis
    G Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza San Giovanni Rotondo, Italy
    J Biol Regul Homeost Agents 26:81-8. 2012
  9. doi request reprint Clock genes and clock-controlled genes in the regulation of metabolic rhythms
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo FG, Italy
    Chronobiol Int 29:227-51. 2012
  10. pmc Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly
    Gianluigi Mazzoccoli
    Unit of Internal Medicine, Department of Medical Sciences, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Age (Dordr) 34:751-60. 2012

Collaborators

Detail Information

Publications43

  1. doi request reprint The circadian clock and the hypoxic response pathway in kidney cancer
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Cappuccini Avenue, San Giovanni Rotondo, FG, 71013, Italy
    Tumour Biol 35:1-7. 2014
    ....
  2. doi request reprint Caloric restriction and aging stem cells: the stick and the carrot?
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo, FG, Italy Electronic address
    Exp Gerontol 50:137-48. 2014
    ..The scope of this review is to highlight how caloric restriction impacts on diverse stem cell compartments and, by doing so, might differentially delay aging in the tissues of lower and higher organisms. ..
  3. pmc Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S, Giovanni Rotondo FG, Italy
    BMC Med Genomics 6:37. 2013
    ..We aimed to evaluate the expression of CGs and downstream CCGs in HS, before and after enzyme replacement treatment with IDS...
  4. doi request reprint Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Chronobiol Int 29:1300-11. 2012
    ....
  5. ncbi request reprint Hormone and cytokine circadian alteration in non-small cell lung cancer patients
    G Mazzoccoli
    Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Int J Immunopathol Pharmacol 25:691-702. 2012
    ..A therapeutic strategy needs to take into account circadian patterns and complex interactions of the multiple functions that characterize the hormone and cytokine levels in the frame cancer progression...
  6. doi request reprint Association study of a polymorphism in clock gene PERIOD3 and risk of inflammatory bowel disease
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Chronobiol Int 29:994-1003. 2012
    ....
  7. ncbi request reprint REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge
    G Mazzoccoli
    Department of Medical Sciences, Scientific Institute and Regional General Hospital, Casa Sollievo della Sofferenza, Italy
    J Biol Regul Homeost Agents 26:265-76. 2012
    ....
  8. ncbi request reprint Concomitant evaluation of flow-mediated vasodilation and epicardial fat thickness in idiopathic deep venous thrombosis
    G Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza San Giovanni Rotondo, Italy
    J Biol Regul Homeost Agents 26:81-8. 2012
    ....
  9. doi request reprint Clock genes and clock-controlled genes in the regulation of metabolic rhythms
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo FG, Italy
    Chronobiol Int 29:227-51. 2012
    ..A complete loss of rhythmicity or a change of phase may alter the physiological array of rhythms, with the onset of chronodisruption or internal desynchronization, leading to metabolic derangement and disease, i.e., chronopathology...
  10. pmc Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly
    Gianluigi Mazzoccoli
    Unit of Internal Medicine, Department of Medical Sciences, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Age (Dordr) 34:751-60. 2012
    ..Aging per se may be associated with physiologic abnormalities in the systemic arteries and with endothelial dysfunction...
  11. doi request reprint Antiphase signalling in the neuroendocrine-immune system in healthy humans
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, S Giovanni Rotondo, Italy
    Biomed Pharmacother 65:275-9. 2011
    ..We have analyzed the dynamics of variation of specific lymphocyte subsets in healthy humans...
  12. ncbi request reprint Epicardial adipose tissue and idiopathic deep venous thrombosis: an association study
    Gianluigi Mazzoccoli
    Unit of Internal Medicine, Department of Medical Sciences, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Atherosclerosis 223:378-83. 2012
    ..Advancing age is characterized by alterations of body fat mass and function In this study we studied the association between EpiF, DVT, age, obesity and other atherosclerosis risk factors...
  13. doi request reprint Circadian aspects of growth hormone-insulin-like growth factor axis function in patients with lung cancer
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Clin Lung Cancer 13:68-74. 2012
    ..Growth hormone (GH) stimulates IGF1 production in liver and other tissues. The aim of our study was to evaluate differences between healthy subjects and patients with lung cancer in the GH-IGF1 axis function...
  14. doi request reprint ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer
    Gianluigi Mazzoccoli
    Division of Internal Medicine and Chronobiology Unit, IRCCS Casa Sollievo della Sofferenza, Research Hospital, San Giovanni Rotondo, FG, Italy
    J Cancer Res Clin Oncol 138:501-11. 2012
    ..Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating PAI-1 levels...
  15. ncbi request reprint Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer
    Anna Panza
    Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia 71013, Italy
    Biochim Biophys Acta 1843:1225-36. 2014
    ....
  16. doi request reprint Stage dependent destructuration of neuro-endocrine-immune system components in lung cancer patients
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Biomed Pharmacother 65:69-76. 2011
    ..The aim of our study was to evaluate the prophiles of time-related variation of neuro-endocrine-immune system components in lung cancer patients...
  17. doi request reprint Alteration of hypothalamic-pituitary-thyroid axis function in non-small-cell lung cancer patients
    Gianluigi Mazzoccoli
    Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Integr Cancer Ther 11:327-36. 2012
    ..When compared with healthy controls, cancer patients showed modifications of hormone serum levels overall and a negative correlation between individual TRH and FT4 levels...
  18. pmc Mirna expression profiles identify drivers in colorectal and pancreatic cancers
    Ada Piepoli
    Department and Laboratory of Gastroenterology, IRCCS Casa Sollievo della Sofferenza, Research Hospital, San Giovanni Rotondo, Italy
    PLoS ONE 7:e33663. 2012
    ..The study of the associations of miRNA expression profile and cancer phenotype could help identify the links between deregulation of miRNA expression and oncogenic pathways...
  19. ncbi request reprint Melatonin and cortisol serum levels in lung cancer patients at different stages of disease
    Gianluigi Mazzoccoli
    Department of Internal Medicine, Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Med Sci Monit 11:CR284-288. 2005
    ..We investigated whether there are differences among healthy elderly people and elderly people suffering from lung cancer at different stages of disease in 24-hour melatonin and cortisol secretory profiles...
  20. ncbi request reprint A possible mechanism for altered immune response in the elderly
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Cappuccini Avenue, 71013 S Giovanni Rotondo FG, Italy
    In Vivo 24:471-87. 2010
    ..Aging is associated with changes in immune function. The aim of this study was to evaluate circadian variations of some endocrine and immune factors in the elderly...
  21. pmc Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations
    Gianluigi Mazzoccoli
    Department of Internal Medicine, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S, Giovanni Rotondo FG, Italy
    J Circadian Rhythms 8:6. 2010
    ..The aim of our study was to analyze the dynamics of variation of specific cytotoxic lymphocyte subsets in old aged subjects...
  22. doi request reprint Comparison of circadian characteristics for cytotoxic lymphocyte subsets in non-small cell lung cancer patients versus controls
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Clin Exp Med 12:181-94. 2012
    ....
  23. doi request reprint The expression of leucine-rich repeat gene family members in colorectal cancer
    Ada Piepoli
    Laboratory and Division of Gastroenterology, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Cappuccini n 1, San Giovanni Rotondo FG, Italy
    Exp Biol Med (Maywood) 237:1123-8. 2012
    ..SHOC2 and LRRC28 genes involved in RAS-mediated signaling, which hinders nutrient deprivation-induced autophagy, might be a possible link between the negative control of autophagy and tumorigenesis...
  24. doi request reprint Altered expression of the clock gene machinery in kidney cancer patients
    Gianluigi Mazzoccoli
    Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Biomed Pharmacother 66:175-9. 2012
    ..The dysregulation of the circadian clock circuitry is involved in carcinogenesis. The aim of our study was to evaluate the clock gene machinery in kidney cancer...
  25. doi request reprint Neuroendocrine-immune interactions in healthy aging
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Geriatr Gerontol Int 11:98-106. 2011
    ..The aim of this study was to evaluate integration among the nervous, endocrine and immune systems in the elderly...
  26. doi request reprint Determination of whole body circadian phase in lung cancer patients: melatonin vs. cortisol
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute, Regional General Hospital Casa Sollievo della Sofferenza, Cappuccini Avenue, 71013 San Giovanni Rotondo FG, Italy
    Cancer Epidemiol 36:e46-53. 2012
    ..In this study we evaluated feasible methodologies to individualize whole body circadian phase in lung cancer patients...
  27. pmc Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes
    Giorgia Benegiamo
    Gastroenterology Unit, IRCCS Casa Sollievo della Sofferenza, Hospital San Giovanni Rotondo, FG, San Giovanni, Italy
    PLoS ONE 8:e60527. 2013
    ..Disruption of biologic clocks is implicated in a variety of disorders including fatty liver disease, obesity and diabetes. The relation between HCV replication and the circadian clock is unknown...
  28. pmc Altered time structure of neuro-endocrine-immune system function in lung cancer patients
    Gianluigi Mazzoccoli
    Unit of Internal Medicine, IRCCS Scientific Institute and Regional General Hospital, Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina S Giovanni Rotondo FG, Italy
    BMC Cancer 10:314. 2010
    ....
  29. doi request reprint Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly
    Gianluigi Mazzoccoli
    Department of Medical Sciences, Division of Internal Medicine, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Exp Gerontol 47:988-93. 2012
    ....
  30. doi request reprint Chronodisruption in lung cancer and possible therapeutic approaches
    Gianluigi Mazzoccoli
    Department of Internal Medicine and Chronobiology Unit, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Biomed Pharmacother 65:500-8. 2011
    ....
  31. pmc Effects of hypercapnia on peripheral vascular reactivity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
    Angela de Matthaeis
    Division of Internal Medicine and Chronobiology Unit, Foggia, Italy
    Clin Interv Aging 9:871-8. 2014
    ....
  32. pmc SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation
    Valerio Pazienza
    Department of Medical Sciences, Gastroenterology Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Aging (Albany NY) 6:35-47. 2014
    ..1 over-expressing cells display ameliorated glucose metabolism, reduced expression of lipidogenic genes and fatty acids content. SIRT1/macroH2A1.1-dependent epigenetic regulation of lipid metabolism may be relevant to NAFLD development. ..
  33. ncbi request reprint Anti-tumor necrosis factor-α therapy and changes of flow-mediated vasodilatation in psoriatic and rheumatoid arthritis patients
    Gianluigi Mazzoccoli
    Department of Internal Medicine, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, Cappuccini Avenue, 71013 S Giovanni Rotondo FG, Italy
    Intern Emerg Med 5:495-500. 2010
    ..197). In conclusion, the use of biological drugs in patients affected by autoimmune arthritis can modify the endothelial function, as indicated by the induced FMD changes, but the long-term effect tends to be considerably reduced...
  34. doi request reprint A unifying working hypothesis for juvenile polyposis syndrome and Ménétrier's disease: specific localization or concomitant occurrence of a separate entity?
    Ada Piepoli
    Laboratory of Gastroenterology, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Dig Liver Dis 44:952-6. 2012
    ..Juvenile polyposis syndrome with gastric involvement may mimic Ménétrier's disease, which is correlated to transforming growth factor (TGF)α overproduction and PDX1 upregulation in the gastric fundus...
  35. doi request reprint A linear mixed model approach to compare the evolution of multiple biological rhythms
    Andrea Fontana
    Unit of Biostatistics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Stat Med 32:1125-35. 2013
    ..Finally, the corresponding SAS syntax is provided...
  36. doi request reprint DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes
    Giorgia Benegiamo
    Gastroenterology Unit, I R C C S Casa Sollievo Della Sofferenza Hospital, San Giovanni Rotondo, Foggia, Italy
    Dig Dis Sci 57:1598-603. 2012
    ..Hepatitis C virus infects ~3% of the population and it is a risk factor for hepatocarcinogenesis. The epigenetic mechanisms of HCV-induced hepatocyte transformation towards malignancy in this context are unclear...
  37. ncbi request reprint [Non-invasive hemodynamic assessment with bioimpedance in patients with subclinical hypothyroidism before and after treatment with levo-thyroxin]
    Marco La Viola
    Dipartimento di Medicina Interna, IRCCS Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, S Giovanni Rotondo
    Recenti Prog Med 94:549-53. 2003
    ..TSH levels were decreased in a statistically significant way. Results obtained in our study show that hemodynamic pattern is not changed after hormone therapy in patients affected by subclinical hypothyroidism...
  38. ncbi request reprint [Interstitial lung diseases]
    Gianluigi Mazzoccoli
    Divisione di Medicina Interna, IRCCS Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo
    Recenti Prog Med 94:227-37. 2003
    ..For their smoldering evolution and not specificity of symptoms (exertional dyspnea and cough) ILD may remain not diagnosed and not treated for a long time...
  39. doi request reprint Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer
    Anna Panza
    Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital, Italy
    Biochim Biophys Acta 1833:1853-65. 2013
    ....
  40. ncbi request reprint SIRT1 and the clock gene machinery in colorectal cancer
    Valerio Pazienza
    Division and Laboratory of Gastroenterology, IRCCS Casa Sollievo della Sofferenza, Research Hospital, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo FG, Italy
    Cancer Invest 30:98-105. 2012
    ..SIRT1 expression was heterogeneous in human CRC and in CRC cell lines. These results might have relevant implications for a better understanding of colorectal carcinogenesis...
  41. ncbi request reprint Rheumatoid arthritis and the biological clock
    Angelo De Cata
    Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Expert Rev Clin Immunol 10:687-95. 2014
    ....
  42. pmc Circadian clock circuitry in colorectal cancer
    Gianluigi Mazzoccoli
    Gianluigi Mazzoccoli, Manlio Vinciguerra, Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo Foggia, Italy
    World J Gastroenterol 20:4197-207. 2014
    ..In this review we describe the involvement of the circadian clock circuitry in colorectal carcinogenesis and the therapeutic strategies addressing temporal deregulation in colorectal cancer. ..
  43. ncbi request reprint [Melatonin in the international literature of the last twenty years]
    Gianluigi Mazzoccoli
    Dipartimento di Medicina Interna, IRCCS Casa Sollievo della Sofferenza, Opera di Padre Pio da Pietrelcina, S Giovanni Rotondo, Foggia
    Recenti Prog Med 94:172. 2003
    ..Today the pineal hormone has reached a great popularity, may be not strictly corresponding to the important role played in the regulation of many system function and the commercial diffusion has become extremely wide in some countries...