V Martinelli

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. doi request reprint Disclosing the diagnosis of multiple sclerosis: the Profile Project
    Vittorio Martinelli
    Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 48, 20132 Milan, Italy
    J Neurol 259:2605-10. 2012
  2. ncbi request reprint Induction versus escalation therapy
    V Martinelli
    Department of Neurology, Scientific Institute H San Raffaele, Via Olgettina 48, I 20132, Milan, Italy
    Neurol Sci 26:S193-9. 2005
  3. ncbi request reprint Combination therapy
    V Martinelli
    Department of Neurology, Scientific Institute H San Raffaele, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 27:S350-4. 2006
  4. ncbi request reprint Late onset multiple sclerosis: clinical characteristics, prognostic factors and differential diagnosis
    V Martinelli
    Department of Neurology, HS Raffaele Scientific Institute, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 25:S350-5. 2004
  5. doi request reprint Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
    V Martinelli
    Department of Neurology, INSPE, San Raffaele Scientific Institute, Milan, Italy
    Neurology 77:1887-95. 2011
  6. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
  7. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
  8. doi request reprint A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:26-30. 2010
  9. doi request reprint Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
    Neurology 75:1134-40. 2010
  10. ncbi request reprint Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement--EEG evidence
    L Leocani
    Department of Neurophysiology, Scientific Institute H. San Raffaele, Milan, Italy
    Neuroimage 13:1186-92. 2001

Detail Information

Publications55

  1. doi request reprint Disclosing the diagnosis of multiple sclerosis: the Profile Project
    Vittorio Martinelli
    Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 48, 20132 Milan, Italy
    J Neurol 259:2605-10. 2012
    ..Improving communication skills may help the therapeutic alliance, enhancing patients' acceptance of the disease, as well as motivation and adherence to treatment...
  2. ncbi request reprint Induction versus escalation therapy
    V Martinelli
    Department of Neurology, Scientific Institute H San Raffaele, Via Olgettina 48, I 20132, Milan, Italy
    Neurol Sci 26:S193-9. 2005
    ..Anyhow, the decision to adopt a combination therapy in patients with a low response to monotherapy should not be delayed until severe irreversible disability is evident...
  3. ncbi request reprint Combination therapy
    V Martinelli
    Department of Neurology, Scientific Institute H San Raffaele, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 27:S350-4. 2006
    ....
  4. ncbi request reprint Late onset multiple sclerosis: clinical characteristics, prognostic factors and differential diagnosis
    V Martinelli
    Department of Neurology, HS Raffaele Scientific Institute, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 25:S350-5. 2004
    ....
  5. doi request reprint Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
    V Martinelli
    Department of Neurology, INSPE, San Raffaele Scientific Institute, Milan, Italy
    Neurology 77:1887-95. 2011
    ..To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics...
  6. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  7. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  8. doi request reprint A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:26-30. 2010
    ..Diffusion tensor (DT) MRI enables quantification of the severity of brain and cervical cord pathology in multiple sclerosis (MS)...
  9. doi request reprint Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
    Neurology 75:1134-40. 2010
    ..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation...
  10. ncbi request reprint Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement--EEG evidence
    L Leocani
    Department of Neurophysiology, Scientific Institute H. San Raffaele, Milan, Italy
    Neuroimage 13:1186-92. 2001
    ....
  11. doi request reprint Absence of diffuse cervical cord tissue damage in early, non-disabling relapsing-remitting MS: a preliminary study
    M Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 14:853-6. 2008
    ..MT MRI-derived measures of cord damage are correlated with the severity of disease-related locomotor disability...
  12. ncbi request reprint In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis
    M Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 124:2540-9. 2001
    ..They also suggest that the severity of multiple sclerosis pathology in the cervical cord is one of the factors contributing to neurological impairment in PP multiple sclerosis...
  13. doi request reprint Lifetime and actual prevalence of pain and headache in multiple sclerosis
    F Martinelli Boneschi
    Department of Neuro Rehabilitation, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 14:514-21. 2008
    ..Pain and headache in MS are not negligible symptoms and a neurological examination should not miss the assessment of risk factors for specific types of pain for a more specific and individualized treatment...
  14. ncbi request reprint Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  15. ncbi request reprint Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI
    B Benedetti
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 67:161-3. 2006
    ..008) and average fractional anisotropy (p = 0.04). There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity (r = 0.52, p = 0.02)...
  16. doi request reprint Development and validation of a patient self-assessed questionnaire on satisfaction with communication of the multiple sclerosis diagnosis
    A Solari
    Neuroepidemiology Unit, Foundation IRCCS Neurological Institute C Besta, Milan, Italy
    Mult Scler 16:1237-47. 2010
    ..We describe the development and clinical validation of a patient self-administered tool assessing the quality of multiple sclerosis diagnosis disclosure...
  17. doi request reprint Breastfeeding is not related to postpartum relapses in multiple sclerosis
    E Portaccio
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 77:145-50. 2011
    ..To assess the relationship between breastfeeding and risk of puerperal relapses in a large cohort of patients with multiple sclerosis (MS)...
  18. ncbi request reprint Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
    G Comi
    Multiple Sclerosis Centre, Department of Neuroscience, IRCCS Ospedale S Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Lancet 357:1576-82. 2001
    ..We assessed the effect of interferon beta-1a on the occurrence of relapses in patients after first presentation with neurological events, who are at high risk of conversion to clinically definite multiple sclerosis...
  19. ncbi request reprint A functional MRI study of movement-associated cortical changes in patients with Devic's neuromyelitis optica
    M A Rocca
    Department of Neuroradiology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 21:1061-8. 2004
    ..The correlation found between fMRI changes and the extent of cord damage suggests that such functional cortical changes might have an adaptive role in limiting the clinical outcome of DNO structural pathology...
  20. doi request reprint An information aid for newly diagnosed multiple sclerosis patients improves disease knowledge and satisfaction with care
    A Solari
    Unit of Neuroepidemiology, Foundation IRCCS Neurological Institute C Besta, Milan, Italy
    Mult Scler 16:1393-405. 2010
    ..Patients report information deficits in the period surrounding diagnosis of multiple sclerosis (MS). We assessed the effectiveness of an add-on information aid for newly diagnosed MS patients...
  21. doi request reprint A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS
    V Martinelli
    Department of Neurology, Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 73:1842-8. 2009
    ..To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse...
  22. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  23. ncbi request reprint A multiparametric MRI study of frontal lobe dementia in multiple sclerosis
    G Comi
    Clinical Trials Unit, Department of Neuroscience, Scientific Institute H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 171:135-44. 1999
    ..Cerebellar MTR histogram metrics did not significantly differ in patients with and without cognitive decline. The presence of cognitive decline in MS is associated with the extent and pathological severity of brain MRI abnormalities...
  24. doi request reprint Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Lancet 374:1503-11. 2009
    ..We assessed the efficacy of early treatment with glatiramer acetate in delaying onset of clinically definite multiple sclerosis...
  25. doi request reprint A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis
    M Gironi
    Institute of Experimental Neurology INSPE and Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Mult Scler 14:1076-83. 2008
    ..BE concentration increased during the trial, but no association was found between OPRM1 variants and improvement of spasticity. Our data clearly indicate that LDN is safe and well tolerated in patients with PPMS...
  26. doi request reprint The Multiple Sclerosis Knowledge Questionnaire: a self-administered instrument for recently diagnosed patients
    A Giordano
    Unit of Neuroepidemiology, Foundation IRCCS Neurological Institute C Besta, Milan, Italy
    Mult Scler 16:100-11. 2010
    ..In conclusion, the MSKQ has good clinimetric properties and is sensitive to an educational intervention. We propose the MSKQ as a brief instrument for clinical practice and research...
  27. pmc Multimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study
    L Leocani
    Department of Neurology, Clinical Neurophysiology and Neurorehabilitation, Scientific Institute Hospital San Raffaele, University Vita Salute, Milan, Italy
    J Neurol Neurosurg Psychiatry 77:1030-5. 2006
    ..Evoked potentials are used in the functional assessment of sensory and motor pathways. Their usefulness in monitoring the evolution of multiple sclerosis has not been fully clarified...
  28. ncbi request reprint Clinical and MRI assessment of brain damage in MS
    G Comi
    Department of Neuroscience, Scientific Institute H San Raffaele, Milan, Italy
    Neurol Sci 22:S123-7. 2001
    ..Other factors, such as the site of MS lesions and the presence of active inflammation, also seem to play an important role...
  29. ncbi request reprint Beta-endorphin concentrations in peripheral blood mononuclear cells of patients with multiple sclerosis: effects of treatment with interferon beta
    M Gironi
    Neurology Department, San Raffaele Hospital, Via Olgettina 48, Milan, Italy
    Arch Neurol 57:1178-81. 2000
    ..Interferon beta (IFN-beta) is a well-established therapy for multiple sclerosis (MS), but immunological mechanisms underlying its beneficial effects in MS are partially undefined...
  30. doi request reprint A multicenter assessment of cervical cord atrophy among MS clinical phenotypes
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University, Milan, Italy
    Neurology 76:2096-102. 2011
    ....
  31. ncbi request reprint Primary angiitis of the central nervous system: serial MRI of brain and spinal cord
    A Campi
    Department of Neuroradiology, San Raffaele Hospital and University, Milan, Italy
    Neuroradiology 43:599-607. 2001
    ..Simultaneous enhancement of brain and spinal cord lesions and of perivascular spaces, at the onset of the disease, which resolves during follow-up, can therefore suggest PACNS...
  32. ncbi request reprint Magnetization transfer and diffusion tensor MRI show gray matter damage in neuromyelitis optica
    M A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 62:476-8. 2004
    ..Compared to healthy controls, patients with NMO showed reduced MT ratio and increased mean diffusivity of the NAGM. This challenges the classic notion of a sparing of the brain tissue in the course of NMO...
  33. ncbi request reprint Movement preparation is affected by tissue damage in multiple sclerosis: evidence from EEG event-related desynchronization
    L Leocani
    Department of Neurology, Clinical Neurophysiology and Neurorehabilitation, Scientific Institute, Hospital San Raffaele, University Vita Salute, Via Olgettina 60, 20132 Milan, Italy
    Clin Neurophysiol 116:1515-9. 2005
    ..To investigate the impact of brain tissue damage in Multiple Sclerosis (MS) on the efficiency of programming of voluntary movement, assessed using event-related desynchronization of the EEG...
  34. doi request reprint Clinical and MRI predictors of response to interferon-beta and glatiramer acetate in relapsing-remitting multiple sclerosis patients
    M Romeo
    Department of Neurology, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy
    Eur J Neurol 20:1060-7. 2013
    ..Our objective is to identify the baseline clinical and magnetic resonance imaging (MRI) predictors of response to first-line DMTs in a cohort of relapsing-remitting (RR) MS patients in a real-world clinical setting...
  35. doi request reprint Efficacy and tolerability of natalizumab in relapsing-remitting multiple sclerosis patients: a post-marketing observational study
    F Sangalli
    Department of Neurology, INSPE, IRCCS H San Raffaele, Via Olgettina 48, 20132, Milan, Italy
    Neurol Sci 31:299-302. 2011
    ..We reported 34 cases of treatment interruptions. In conclusion, our data confirm the remarkable efficacy of natalizumab in a group of patients with higher disease activity than that of pivotal studies...
  36. ncbi request reprint The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study
    C Solaro
    Department of Neurology, P A Micone Hospital, Genova, Italy
    Neurology 63:919-21. 2004
    ..This study underlines the relevance of pain in the clinical history of MS...
  37. doi request reprint Cognitive impairment and structural brain damage in benign multiple sclerosis
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 71:1521-6. 2008
    ..Against this background, we investigated the extent of structural brain damage underlying cognitive dysfunction in BMS, with the ultimate aim to move a first step toward a more reliable definition of this disease phenotype...
  38. doi request reprint Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosis
    M P Amato
    Department of Neurology, University of Florence, Florence, Italy
    Neurology 75:1794-802. 2010
    ..To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) in all pregnancies occurring in women with multiple sclerosis (MS) during the study period, with a specific focus on the risk of spontaneous abortion...
  39. ncbi request reprint Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques
    G Comi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 172:S63-6. 2000
    ..Other factors, such as the site of MS lesions and the presence of active inflammation, also seem to play an important role...
  40. doi request reprint Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort
    F Martinelli-Boneschi
    Department of Neurology, Institute of Experimental Neurology INSPE, San Raffaele Scientific Institute, Milan, Italy
    Eur J Neurol 17:740-5. 2010
    ....
  41. doi request reprint Treatment of Wernicke's encephalopathy with high dose of thiamine in a patient with pyloric sub-stenosis: description of a case
    Francesca Caso
    Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 48, Milan, Italy
    Neurol Sci 31:859-61. 2010
    ....
  42. doi request reprint Mitoxantrone: benefits and risks in multiple sclerosis patients
    V Martinelli
    Neurology Department, INSPE, University IRCCS San Raffaele, Milan, Italy
    Neurol Sci 30:S167-70. 2009
    ..Therefore, all potential serious adverse events should be carefully considered against the potential relevant benefits of MTX treatment on every single MS patient...
  43. doi request reprint Painful cervical dystonia triggered by the extension wire of a deep brain stimulator
    F Spagnolo
    Department of Neurology, INSPE, San Raffaele Scientific Institute, Via Olgettina 48, I 20132 Milan, Italy
    J Clin Neurosci 19:1582-3. 2012
    ..The patient was referred back to surgery to reposition the pulse generator in the contralateral subclavian region. A deeper channeling of the wire extensions produced a complete remission of the painful dystonia...
  44. doi request reprint Anxiety and depression in multiple sclerosis patients around diagnosis
    Andrea Giordano
    Unit of Neuroepidemiology, Foundation IRCCS Neurological Institute C Besta, Milan, Italy
    J Neurol Sci 307:86-91. 2011
    ..To prospectively identify anxiety and depressive symptoms, and their predictors, during the multiple sclerosis (MS) peridiagnostic period...
  45. pmc A post-marketing study on interferon beta 1b and 1a treatment in relapsing-remitting multiple sclerosis: different response in drop-outs and treated patients
    C Milanese
    Centro Regionale per la Cura della Sclerosi Multipla, Istituto Nazionale Neurologico C Besta, Milan, Italy
    J Neurol Neurosurg Psychiatry 74:1689-92. 2003
    ..Interferon beta 1b (Betaferon) and 1a (Avonex) were licensed in Italy for treating relapsing-remitting multiple sclerosis in February 1996 and August 1997, respectively...
  46. ncbi request reprint Cord damage elicits brain functional reorganization after a single episode of myelitis
    M A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 61:1078-85. 2003
    ....
  47. ncbi request reprint Non-demyelinating optic neuropathy: clinical entities
    V Martinelli
    Department of Neuroscience, Scientific Institute H.S. Raffaele, University Vita-Salute, Milan, Italy
    Neurol Sci 22:S55-9. 2001
    ..Atypical clinical cases of optic neuropathy require further specific laboratory, neurophysiological and imaging tests to make a correct and early diagnosis...
  48. doi request reprint Striatal hand in Parkinson's disease: the re-evaluation of an old clinical sign
    Francesca Spagnolo
    Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 48, 20132, Milan, Italy
    J Neurol 261:117-20. 2014
    ..We recommend including an evaluation for SH as part of routine practice. This study emphasizes the importance of a careful observation of the patient in order to improve diagnostic accuracy. ..
  49. ncbi request reprint Spinal cord involvement in primary angiitis of the central nervous system: a report of two cases
    A Campi
    Department of Neuroradiology, Scientific Institute and University San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 22:577-82. 2001
    ..Numerous small and enhancing abnormalities with a primarily posterior location, seen at the onset of the disease and resolved on follow-up studies, may be considered suggestive of a diagnosis of primary angiitis of the CNS...
  50. ncbi request reprint Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:433-7. 2003
    ..This finding lessens the validity of the current concept that the axonal pathology of multiple sclerosis is the end-stage result of repeated inflammatory events, and argues strongly in favour of early neuroprotective intervention...
  51. doi request reprint Neurodegeneration in the course of Langerhans cell histiocytosis
    F Spagnolo
    Department of Neurology, INSPE, San Raffaele Scientific Institute, Via Olgettina 48, 20132, Milan, Italy
    Neurol Sci 33:605-7. 2012
    ....
  52. ncbi request reprint Communicating the diagnosis of multiple sclerosis - a qualitative study
    A Solari
    Neuroepidemiology Unit, C Besta National Neurological Institute, Milan, Italy
    Mult Scler 13:763-9. 2007
    ..Such improvements imply a more meaningful patientneurologist relationship, and also structural and organisational changes...
  53. ncbi request reprint Optic neuritis: differential diagnosis
    S Bianchi Marzoli
    Department of Ophthalmology, H S Raffaele Scientific Institute, Vita-Salute University School of Medicine, Milan, Italy
    Neurol Sci 22:S52-4. 2001
    ..As in optic neuritis, optic disc and macula appearance may be completely normal in several retinal diseases. Fluorescein angiography and electrophysiological testing are relevant for the differential diagnosis in many challenging cases...
  54. ncbi request reprint Treatment of early-onset multiple sclerosis with intramuscular interferonbeta-1a: long-term results
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, I 20013, Gallarate, Italy
    Neurol Sci 28:127-32. 2007
    ..IM IFNbeta-1a was effective and well tolerated in these paediatric patients with MS...
  55. ncbi request reprint Disease-modifying drugs in childhood-juvenile multiple sclerosis: results of an Italian co-operative study
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy
    Mult Scler 11:420-4. 2005
    ..The aim of this study was to evaluate the impact of IFNbeta and GA in MS patients treated before 16 years of age...