P Manunta

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin
    Jan A Staessen
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Research, University of Leuven, Leuven, Belgium
    Trials 12:13. 2011
  2. ncbi request reprint A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin
    Paolo Manunta
    Division of Nephrology, Dialysis and Hypertension, University Vita Salute San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy
    Cardiovasc Hematol Agents Med Chem 4:61-6. 2006
  3. ncbi request reprint Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm
    Paolo Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffale, Via Olgettina 60, 20131 Milan, Italy
    J Am Soc Nephrol 17:S30-5. 2006
  4. ncbi request reprint Adducin polymorphisms and the treatment of hypertension
    Paolo Manunta
    Universita Vita Salute San Raffaele Hospital, Division of Nephrology, Dialysis and Hypertension, Scientific Institute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Pharmacogenomics 8:465-72. 2007
  5. pmc Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension
    Paolo Manunta
    Division of Nephrology, Dialysis and Hypertension, Scientific Institute San Raffaele, University Vita Salute San Raffaele, Milan, Italy
    J Hypertens 26:914-20. 2008
  6. doi request reprint Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation
    Paolo Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy
    Hypertension 52:366-72. 2008
  7. ncbi request reprint Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension
    P Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffaele, Milan, Italy
    Hypertension 38:198-203. 2001
  8. doi request reprint Endogenous ouabain in cardiovascular function and disease
    Paolo Manunta
    San Raffaele Scientific Institute, Division of Nephrology, Dialysis, and Hypertension, Universita Vita Salute San Raffaele Hospital, Milan, Italy
    J Hypertens 27:9-18. 2009
  9. pmc Endogenous ouabain in renal Na(+) handling and related diseases
    Paolo Manunta
    Scientific Institute San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Biochim Biophys Acta 1802:1214-8. 2010
  10. ncbi request reprint Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension
    P Manunta
    University of Milan and Division of Nephrology, Dialysis and Hypertension, IRCCS San Raffaele Hospital, Milan, Italy
    Hypertension 34:450-6. 1999

Collaborators

Detail Information

Publications45

  1. pmc Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin
    Jan A Staessen
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Research, University of Leuven, Leuven, Belgium
    Trials 12:13. 2011
    ..Rostafuroxin lowered blood pressure (BP) in some animal models and in humans...
  2. ncbi request reprint A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin
    Paolo Manunta
    Division of Nephrology, Dialysis and Hypertension, University Vita Salute San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy
    Cardiovasc Hematol Agents Med Chem 4:61-6. 2006
    ..In conclusion, PST2238, because of its peculiar action mechanism, represents a new tool to disentangle the complex relationship between salt intake, genetic control of renal sodium handling and EO effect...
  3. ncbi request reprint Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm
    Paolo Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffale, Via Olgettina 60, 20131 Milan, Italy
    J Am Soc Nephrol 17:S30-5. 2006
    ....
  4. ncbi request reprint Adducin polymorphisms and the treatment of hypertension
    Paolo Manunta
    Universita Vita Salute San Raffaele Hospital, Division of Nephrology, Dialysis and Hypertension, Scientific Institute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Pharmacogenomics 8:465-72. 2007
    ....
  5. pmc Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension
    Paolo Manunta
    Division of Nephrology, Dialysis and Hypertension, Scientific Institute San Raffaele, University Vita Salute San Raffaele, Milan, Italy
    J Hypertens 26:914-20. 2008
    ..The basolateral Na pump drives renotubular reabsorption. In cultured renal cells, mutant adducins, as well as sub-nanomolar ouabain concentrations, stimulate the Na-K pump...
  6. doi request reprint Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation
    Paolo Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy
    Hypertension 52:366-72. 2008
    ..Relatively common alleles in the ADD1, WNK1, and NEDD4L genes when present in combination may have significant effects on renal sodium handling, BP, and antihypertensive response to thiazides...
  7. ncbi request reprint Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension
    P Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffaele, Milan, Italy
    Hypertension 38:198-203. 2001
    ..Taken together, these new results suggest that ouabain-like factor is involved in the adaptation of humans to sodium depletion and argue against the hypothesis that ouabain-like factor is a natriuretic hormone...
  8. doi request reprint Endogenous ouabain in cardiovascular function and disease
    Paolo Manunta
    San Raffaele Scientific Institute, Division of Nephrology, Dialysis, and Hypertension, Universita Vita Salute San Raffaele Hospital, Milan, Italy
    J Hypertens 27:9-18. 2009
    ..The outstanding analytical issues include the elucidation of distal events in the biosynthetic pathway for endogenous ouabain and identification of molecular mechanisms that regulate its secretion and clearance...
  9. pmc Endogenous ouabain in renal Na(+) handling and related diseases
    Paolo Manunta
    Scientific Institute San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Biochim Biophys Acta 1802:1214-8. 2010
    ..Finally, maneuvers that promote Na depletion, as diuretic therapy or reduced Na intake, raise the EO levels. Taken together, these findings suggest a key role for EO in body Na homeostasis...
  10. ncbi request reprint Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension
    P Manunta
    University of Milan and Division of Nephrology, Dialysis and Hypertension, IRCCS San Raffaele Hospital, Milan, Italy
    Hypertension 34:450-6. 1999
    ..We propose that the OLF affects cardiovascular function and structure and should be considered as a factor that contributes to the risk of morbid events...
  11. ncbi request reprint Adducin polymorphism affects renal proximal tubule reabsorption in hypertension
    P Manunta
    Division of Nephrology, University of Milan, Italy
    Hypertension 33:694-7. 1999
    ..In conclusion, the adducin gene can be considered to be a 'renal hypertensive gene' that modulates the capacity of tubular epithelial cells to transport Na+ and hence contributes to the level of blood pressure...
  12. pmc Endogenous ouabain and the renin-angiotensin-aldosterone system: distinct effects on Na handling and blood pressure in human hypertension
    Paolo Manunta
    Nephrology, and Dialysis San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milan, Italy
    J Hypertens 29:349-56. 2011
    ..To evaluate whether the renin-angiotensin-aldosterone system (RAAS) and endogenous ouabain system differently affect renal Na handling and blood pressure...
  13. ncbi request reprint High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals
    Paolo Manunta
    Division of Nephrology, Dialysis and Hypertension, University Vita e Salute San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy
    J Hypertens 23:1677-81. 2005
    ..The aim of this study was to investigate whether these cardiac modifications are related to plasma EO levels in the offspring of hypertensive families...
  14. ncbi request reprint Erythrocyte calcium influx is related to severity of ventricular arrhythmias in uraemic patients
    L Soldati
    Division of Nephrology, Dialysis and Hypertension, San Raffaele Scientific Institute, University of Milan, Italy
    Nephrol Dial Transplant 16:85-90. 2001
    ..Reduced resistance to PTH could contribute to this phenomenon...
  15. ncbi request reprint Hypertension in hemodialysis patients
    M Querques
    Operative Unit of Nephrology and Dialysis, Department of Nephrology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Minerva Urol Nefrol 62:41-50. 2010
    ....
  16. pmc Endogenous ouabain and cardiomyopathy in dialysis patients
    P Stella
    Division of Nephrology, Dialysis, and Hypertension, University Vita e Salute, San Raffaele Hospital, Milan, Italy
    J Intern Med 263:274-80. 2008
    ..EO was measured by a specific radioimmunoassay and by mass spectrometry...
  17. ncbi request reprint Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension
    D Cusi
    Postgraduate School of Nephrology, University of Milan, Italy
    Lancet 349:1353-7. 1997
    ..We investigated whether an alpha-adducin polymorphism (Gly 460 Trp) is involved in essential hypertension in two separate populations...
  18. ncbi request reprint Adducin in essential hypertension
    P Manunta
    Postgraduate School of Nephrology, University of Milan and Division of Nephrology, Dialysis and Hypertension, S Raffaele Hospital, Italy
    FEBS Lett 430:41-4. 1998
    ..However adducin polymorphisms account for only a portion of hypertension both in humans and rats. Therefore additive or epistatic interactions with other genes involved in renal sodium handling need to be studied...
  19. doi request reprint Genetics of primary hypertension: the clinical impact of adducin polymorphisms
    Lorena Citterio
    San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milan, Italy
    Biochim Biophys Acta 1802:1285-98. 2010
    ..The size of this impact is variable and affected by the context...
  20. pmc Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain
    Grazia Tripodi
    Prassis Sigma Tau, Research Institute, Milan, Italy
    Am J Hypertens 22:357-63. 2009
    ..Furthermore, the renal excretion of cardiac glycosides is mediated by the organic anion transporter (SLCO4C1) at the basolateral membrane and the P-glycoprotein (PGP) (encoded by MDR1) at the apical membrane of the nephron...
  21. ncbi request reprint Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension
    Cristina Barlassina
    Department of Sciences and Biomedical Technologies, University of Milan, via Fantoli 16 15, 20090 Milan, Italy
    Hum Mol Genet 16:1630-8. 2007
    ..This study supports the candidacy of CLCNKA as a new susceptibility gene for salt-sensitivity...
  22. ncbi request reprint ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy
    Maria Teresa Sciarrone
    Department of Nephrology and Graduate School of Nephrology Universita Vita e Salute, Milan, Italy
    Hypertension 41:398-403. 2003
    ....
  23. ncbi request reprint Role of the adducin family genes in human essential hypertension
    Chiara Lanzani
    Division of Nephrology, Dialysis and Hypertension University Vita Salute, IRCCS San Raffaele Hospital, Milano, Italy
    J Hypertens 23:543-9. 2005
    ..Adducin functions within cells as a heterodimer composed of various combinations of three subunits that are coded by three genes (ADD1, 2, 3) each located on a different chromosome...
  24. pmc alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy
    Mara Ferrandi
    Prassis sigma tau Research Institute, Settimo Milanese, Milan, Italy
    J Mol Med (Berl) 88:203-17. 2010
    ..These findings suggest that adducin genetic variants participate in the development of glomerular lesions by modulating the expression of specific podocyte proteins...
  25. doi request reprint Endogenous ouabain in Ménière's disease
    Roberto Teggi
    ENT Department, IRRCS San Raffaele, Milan, Italy
    Otol Neurotol 31:153-6. 2010
    ..Our purpose was to measure plasma levels of EO in Ménière's Disease (MD) subjects as a possible predisposing factor to developing and maintaining hydrops...
  26. doi request reprint Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome
    Roberto Teggi
    ENT Department, San Raffaele Scientific Institute, Vita Salute University San Raffaele, Milan, Italy
    Otol Neurotol 29:824-8. 2008
    ..ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells. This study aims to verify the role of adducin in the development of MD...
  27. ncbi request reprint Low-salt diet and diuretic effect on blood pressure and organ damage
    Paolo Manunta
    Division of Nephrology, Dialysis and Hypertension, University Vita Salute San Raffaele Hospital, Milan, Italy
    J Am Soc Nephrol 15:S43-6. 2004
    ..These data support the notion that matching of the genetic mechanism with the drug mechanisms of action produces a clear therapeutic benefit...
  28. ncbi request reprint Genetics of essential hypertension: from families to genes
    Cristina Barlassina
    Division of Nephrology, Dyalisis and Hypertension, University Vita e Salute San Raffaele Hospital, Milan, Italy
    J Am Soc Nephrol 13:S155-64. 2002
    ..A negative finding or a minor genetic effect in a general population may become a major gene effect in a subset of people with the appropriate genetic and environmental backgrounds...
  29. ncbi request reprint The clinical pathway for hypertensive patient of local health unit, hospitals and general practitioners, the Milan experience
    Alberto Donzelli
    Service of Education for Appropriateness and Evidence Based Medicine Local Health Unit, ASL of Milan, Italy
    Rev Recent Clin Trials 6:16-23. 2011
    ....
  30. ncbi request reprint Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach
    Patrizia Ferrari
    Prassis Istituto di Ricerche Sigma Tau, Settimo Milanese, Milano, Italy
    Med Hypotheses 68:1307-14. 2007
    ..Currently, a phase II multicenter European clinical trial is ongoing for providing the proof of concept that such a compound is effective in the subset of patients where these two mechanisms are at work...
  31. ncbi request reprint The endogenous ouabain: molecular basis of its role in hypertension and cardiovascular complications
    Mara Ferrandi
    Prassis sigma tau Research Institute, Settimo Milanese, 20019 Milan, Italy
    Front Biosci 10:2472-7. 2005
    ....
  32. ncbi request reprint Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers
    Chikh Bengra
    Department of Pathology, The University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
    Clin Chem 48:2131-40. 2002
    ..A genetic screening test based on analysis of multiple single-nucleotide polymorphisms (SNPs) to assess the likelihood of developing hypertension would be helpful for disease management...
  33. ncbi request reprint OASIS-HT: design of a pharmacogenomic dose-finding study
    Jan A Staessen
    Department of Molecular and Cardiovascular Research, Hypertension and Cardiovascular Rehabilitation Unit, Study Coordinating Centre, University of Leuven, Belgium
    Pharmacogenomics 6:755-75. 2005
    ..To our knowledge, OASIS-HT is the first Phase II dose-finding study in which a genetic hypothesis is driving primary and secondary end points...
  34. ncbi request reprint Adducin, renal intermediate phenotypes, and hypertension
    Giuseppe Bianchi
    Hypertension 44:394-5. 2004
  35. ncbi request reprint Are the new single nucleotide polymorphisms (SNPs) relevant for hypertensive populations?
    Paolo Manunta
    J Hypertens 20:2335-6. 2002
  36. ncbi request reprint Salt, endogenous ouabain and blood pressure interactions in the general population
    Ji Guang Wang
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hypertens 21:1475-81. 2003
    ..We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeostasis...
  37. ncbi request reprint Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension
    Speranza Rubattu
    IRCCS Neuromed, Polo Molisano University of Rome La Sapienza, Pozzilli, Italy
    J Am Coll Cardiol 48:499-505. 2006
    ....
  38. ncbi request reprint Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome
    Yan Li
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Research, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertension 49:1291-7. 2007
    ....
  39. ncbi request reprint Na+, kidney, hypertension and genes: lessons from rats
    Giuseppe Bianchi
    J Hypertens 22:1461-4. 2004
  40. ncbi request reprint Different effects of marinobufagenin and endogenous ouabain
    Paolo Manunta
    J Hypertens 22:257-9. 2004
  41. ncbi request reprint Association between arterial properties and renal sodium handling in a general population
    Jitka Seidlerova
    Studies Coordination Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertension 48:609-15. 2006
    ..These findings demonstrate that there might be an influence of renal sodium handling on arterial properties or vice versa or that common mechanisms might influence both arterial and renal function...
  42. ncbi request reprint Haplotype analysis in human hypertension
    Paolo Manunta
    J Hypertens 23:711-2. 2005
  43. ncbi request reprint Salt intake and depletion increase circulating levels of endogenous ouabain in normal men
    Paolo Manunta
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 655 West Baltimore St, Baltimore, Maryland 21201, USA
    Am J Physiol Regul Integr Comp Physiol 290:R553-9. 2006
    ..The dramatic impact of high-salt diets on plasma EO is consistent with its proposed role as a humoral vasoconstrictor that links salt intake with vascular function in hypertension...
  44. ncbi request reprint Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy
    Maria Vittoria Pitzalis
    Institute of Cardiology, University of Bari, Bari, Italy
    Eur J Heart Fail 8:179-86. 2006
    ..This study provides the first evidence that circulating EO is a novel, independent and incremental marker that predicts the progression of heart failure...
  45. ncbi request reprint Ouabain and serum sodium
    Jerzy Gasowski
    Hypertension 45:e16; author reply e16-7. 2005