Research Topics
Genomes and Genes | Angelo A ManfrediSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Publications
Regulation of dendritic- and T-cell fate by injury-associated endogenous signalsAngelo A Manfredi
Vita Salute San Raffaele University and San Raffaele Scientific Institute, 20132 Milano, Italy
Crit Rev Immunol 29:69-86. 2009....- Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodesAngelo A Manfredi
Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
J Immunol 180:2270-5. 2008..Thus the HMGB1-RAGE pathway is a checkpoint in DC maturation and function and a candidate for targeted therapies... 
Dangerous connections: neutrophils and the phagocytic clearance of activated plateletsAngelo A Manfredi
San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
Curr Opin Hematol 17:3-8. 2010..We have summarized the evidence suggesting a homeostatic function of the interaction, culminating in the removal of activated platelets from the bloodstream...- Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end productsIngrid E Dumitriu
Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
J Immunol 174:7506-15. 2005..The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism... - The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cellsParamita Baruah
Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
J Leukoc Biol 80:87-95. 2006.... - The secretion of HMGB1 is required for the migration of maturing dendritic cellsIngrid E Dumitriu
Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milano 20132, Italy
J Leukoc Biol 81:84-91. 2007..Our data suggest that the autocrine/paracrine release of HMGB1 and the integrity of the HMGB1/RAGE pathway are required for the migratory function of DC... - HMGB1: guiding immunity from withinIngrid E Dumitriu
Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
Trends Immunol 26:381-7. 2005..The role of HMGB1 as an endogenous molecule that facilitates immune responses and has an important role in tissue homeostasis and disease will be highlighted here... - Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK/LAK cellsAnnalisa Capobianco
Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
J Immunother 31:458-65. 2008..The response associated to the preferential recruitment within tumors of eosinophils. The simultaneous injection in solid tumors of DCs and NK/LAK cells represents an attractive approach for antineoplastic immunotherapeutic strategies... - Leukocyte and platelet activation in patients with giant cell arteritis and polymyalgia rheumatica: a clue to thromboembolic risks?Norma Maugeri
San Raffaele Scientific Institute, University of Vita Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy
Autoimmunity 42:386-8. 2009..Activated circulating leukocytes and platelets could contribute to indolent vessel inflammation and possibly to thromboembolic events in patients with systemic large vessel vasculitis... - Expansion of T-cell receptor zeta dim effector T cells in acute coronary syndromesEnrico Ammirati
Clinical Cardiovascular Biology Research Centre, Vita Salute San Raffaele University and San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Arterioscler Thromb Vasc Biol 28:2305-11. 2008..We assessed the expression and functional correlates of circulating TCR zeta(dim) T cells in coronary artery disease... - Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and {beta}2 integrin-dependent cell clearance programNorma Maugeri
H San Raffaele Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
Blood 113:5254-65. 2009..The data suggest that the interaction between circulating platelets and neutrophils influences innate immune functions, possibly contributing to regulate vascular inflammation... - High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscleMichela Vezzoli
Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
Antioxid Redox Signal 15:2161-74. 2011..We propose that the early antioxidant response in regenerating muscle limits HMGB1 oxidation, thus allowing successful muscle regeneration... - Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseasesNorma Maugeri
Autoimmunity and Vascular Inflammation Unit, University Vita Salute San Raffaele and San Raffaele Scientific Institute, Milan, Italy
Thromb Res 129:267-73. 2012..Here we will discuss the implications of these results for the pathogenesis and the clinical features of self-sustaining immune-mediated vessel diseases... - Anti-inflammatory action of apoptotic cells in patients with acute coronary syndromesLuca A Ferri
Istituto Scientifico San Raffaele and Università Vita Salute San Raffaele, Milan, Italy
Atherosclerosis 205:391-5. 2009..Atherosclerotic plaques contain both apoptotic cells and phagocytes. Apoptotic cells are known to exert an anti-inflammatory effect. Little is known on their action in patients with acute coronary syndromes... - Innate responses to Aspergillus: role of C1q and pentraxin 3 in nasal polyposisParamita Baruah
Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano, Italy
Am J Rhinol 21:224-30. 2007.... - Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemiaNorma Maugeri
Unit of Autoimmunity and Vascular Inflammation, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Istituto Scientifico San Raffaele and Universita Vita Salute San Raffaele, Milan, Italy
Blood 118:3359-66. 2011.... 
Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivoAttilio Bondanza
Clinical Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, H. San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
J Exp Med 200:1157-65. 2004..Finally, AxV-coupled irradiated cells induced the regression of growing tumors. These data indicate that endogenous adjuvants that bind to dying tumor cells can be exploited to target tumors for immune rejection...- Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunityPatrizia Rovere-Querini
Clinical Immunology Unit, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
Autoimmunity 40:290-4. 2007.... - Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cellsIngrid E Dumitriu
H San Raffaele Scientific Institute, Milan, Italy
Eur J Immunol 35:2184-90. 2005..These results reveal HMGB1 and RAGE as the first known autocrine loop modulating the maturation of PDC, and suggest that antagonists of HMGB1/RAGE might have therapeutic potential for the treatment of systemic human diseases... - Circulating chromogranin A reveals extra-articular involvement in patients with rheumatoid arthritis and curbs TNF-alpha-elicited endothelial activationGabriele Di Comite
Department of Medicine, Oncology and Clinical Immunology Unit, H San Raffaele University Hospital, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
J Leukoc Biol 85:81-7. 2009..Our results suggest that enhanced levels of CgA identify patients with extra-articular involvement and reveal a negative feedback loop that limits the activation of endothelial cells in RA... - Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell functionStefano Pluchino
Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
PLoS ONE 4:e5959. 2009..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs... - Cell death: tipping the balance of autoimmunity and tissue repairPatrizia Rovere-Querini
H San Raffaele Scientific Institute, 20132 Milano, Italy
Curr Pharm Des 14:269-77. 2008.... - Melanoma cells interfere with the interaction of dendritic cells with NK/LAK cellsAnnalisa Capobianco
Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milano, Italy
Int J Cancer 119:2861-9. 2006..Interference with the NK/DC interaction possibly represents a mechanism used by growing tumors to evade the immune response... - Pentraxins, humoral innate immunity and tissue injuryAngelo A Manfredi
H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milan 20132, Italy
Curr Opin Immunol 20:538-44. 2008.... - Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosisNorma Maugeri
San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
Autoimmunity 45:584-7. 2012..These findings indicate that platelets represent a source of HMGB1, an ancestral signal of necrosis, in the vasculature of SSc patients, possible contributing to persistent microvascular injury and endothelial cell activation... - Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cellsSestina Falcone
Vita Salute University and Stem Cell Research Institute, San Raffaele, Milan, Italy
J Immunol 173:4452-63. 2004..Thus, A-SMase plays a central role in E. coli/LPS-induced DC apoptosis and its inhibition by NO, and it might be a target of new therapeutic approaches to sepsis... - The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigensParamita Baruah
Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
Blood 107:151-8. 2006..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells... - Environmental adjuvants, apoptosis and the censorship over autoimmunityPatrizia Rovere-Querini
H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
Autoimmun Rev 4:555-60. 2005..Novel tools for drug development will derive from the molecular identification of the constraints that prevent autoimmunity in normal subjects... - Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemiaMattia Baldini
Istituto Scientifico San Raffaele and Università Vita Salute San Raffaele, Milan, Italy
Arthritis Rheum 64:854-65. 2012..To assess local expression and plasma levels of pentraxin 3 (PTX3) in patients with giant cell arteritis (GCA)... - HMGB1 is an endogenous immune adjuvant released by necrotic cellsPatrizia Rovere-Querini
Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milano, Italy
EMBO Rep 5:825-30. 2004..In vivo, HMGB1 enhances the primary antibody responses to soluble antigens and transforms poorly immunogenic apoptotic lymphoma cells into efficient vaccines... - Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsiaPatrizia Rovere-Querini
Clinical Immunology Unit, Division of Pathology, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
Obstet Gynecol 108:148-55. 2006..We examined whether PTX3 is expressed during pregnancy and possibly involved in the development of preeclampsia... - Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the diseaseAnnalisa Capobianco
Autoimmunity and Vascular Inflammation Unit, San Raffaele Scientific Institute, Milan, Italy
Am J Pathol 179:2651-9. 2011..Thus, TEMs are important for maintaining the viability of newly formed vessels and represent a potential therapeutic target in endometriosis... - Polarization dictates iron handling by inflammatory and alternatively activated macrophagesGianfranca Corna
H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
Haematologica 95:1814-22. 2010..Little is known on whether the polarization program influences the ability of macrophages to store or recycle iron and the molecular machinery involved in the processes... - Characterisation of functional biotinylated TNF-alpha targeted to the membrane of apoptotic melanoma cellsValerie S Zimmermann
Cancer Immunotherapy and Gene Therapy Programme, H San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
J Immunol Methods 276:79-87. 2003..Therefore the bridging of TNF-alpha potentiates its biological function and influences the outcome of the phagocytic clearance of apoptotic tumor cells... - Clinical and experimental evidences on the prothrombotic properties of neutrophilsNorma Maugeri
San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milano, Italy
Srp Arh Celok Lek 138:50-2. 2010.... - Evaluation of the role of tumor-associated macrophages in an experimental model of peritoneal carcinomatosis using (18)F-FDG PETLucia Cottone
Autoimmunity and Vascular Inflammation Unit, San Raffaele Scientific Institute, Milan, Italy
J Nucl Med 52:1770-7. 2011..Here, we established and took advantage of a preclinical model of peritoneal carcinomatosis to evaluate the contribution of inflammatory infiltrating macrophages in tumor progression that was followed using (18)F-FDG PET... - Conversation galante: how the immune and the neuroendocrine systems talk to each otherGabriele Di Comite
H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
Autoimmun Rev 7:23-9. 2007..A better molecular dissection of this finely regulated inter-system cross-talk, in physiological conditions and during self-sustaining inflammatory diseases, might enable more rational therapeutic approaches... - Double-edged effect of Vgamma9/Vdelta2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infectionPriscilla Biswas
Laboratory of Clinical Immunology, Scientific Institute H S Raffaele, Milan, Italy
Eur J Immunol 33:252-63. 2003..Thus, we suggest that specific recognition of mycobacterial Ag by gamma delta T lymphocytes in co-infected individuals may modulate viral replication through the complex array of soluble factors released... - Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosisEnrico Ammirati
Clinical Cardiovascular Biology Research Centre, San Raffaele Scientific Institute and the Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
Arterioscler Thromb Vasc Biol 30:1832-41. 2010..Regulatory T (Treg) cells play a protective role in experimental atherosclerosis. In the present study, we investigated whether the levels of circulating Treg cells relate to the degree of atherosclerosis in carotid and coronary arteries... - High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunityMarco E Bianchi
Faculty of Medicine, San Raffaele University, Milano, Italy
Immunol Rev 220:35-46. 2007..These immune responses will also be directed against self-antigens that DCs process at the time of injury and can lead to autoimmunity... - Cutting edge: dissociation between autoimmune response and clinical disease after vaccination with dendritic cellsAttilio Bondanza
Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology and Rheumatology Unit, H. San Raffaele Scientific Institute, , Milan, Italy
J Immunol 170:24-7. 2003..The data suggest that DC vaccination consistently triggers autoimmune responses. However, clinical autoimmunity develops in susceptible subjects only... - Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal ModelsEnrico Ammirati
Clinical Cardiovascular Biology Centre, San Raffaele Scientific Institute and the Università Vita Salute San Raffaele, Milan, Italy E A, D C, M B Heart Transplantation Division, Ospedale Niguarda Ca Granda, Milan, Italy E A Heart Care Foundation, Florence, Italy E A, A M
J Am Heart Assoc 1:27-41. 2012..J Am Heart Assoc. 2012;1:27-41.)... - Tumor destruction and in situ delivery of antigen presenting cells promote anti-neoplastic immune responses: implications for the immunotherapy of pancreatic cancerPatrizia Rovere-Querini
Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Vita-Salute San Raffaele University. Milan, Italy
JOP 5:308-14. 2004.... - TNF-alpha coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigensValerie S Zimmermann
Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Scientific Institute and San Raffaele Vita Salute University, Milano, Italy
J Immunol 172:2643-50. 2004.... - Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activityBarbara Valentinis
MolMed S p A, Via Olgettina 58, 20132 Milan, Italy
J Leukoc Biol 84:199-206. 2008..No activation of p38 was induced in the same experimental conditions. Our data suggest that the IkappaB-alpha/NF-kappaB pathway has a critical role in the partial maturation of DCs induced by rHSP70... - Synergism of nitric oxide and maturation signals on human dendritic cells occurs through a cyclic GMP-dependent pathwayClara Paolucci
Department Neuroscience, DIBIT-H San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
J Leukoc Biol 73:253-62. 2003..These results provide the first evidence that NO acts as a cosignaling molecule regulating human DC response to maturation stimuli... - Dendritic cells and the shadow line between autoimmunity and diseaseAngelo A Manfredi
Arthritis Rheum 52:11-5. 2005 - Requirement of dying cells and environmental adjuvants for the induction of autoimmunityAttilio Bondanza
H. San Raffaele Scientific Institute and University, Via Olgettina 58, Milan 20132, Italy
Arthritis Rheum 50:1549-60. 2004..Strategies aimed at preventing the accumulation of dying cells and at modulating endogenous adjuvants may be beneficial for the treatment of SLE... - Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytesLorenzo Dagna
Laboratory of Tumor Immunology, Department of Medicine, Scientific Institute H. San Raffaele, Via Olgettina 60, I-20132 Milan, Italy
Eur J Immunol 32:2934-43. 2002..Overall, our data suggest that type-2 differentiation of gamma delta T lymphocytes profoundly affects both their effector functions and their potential to recruit the appropriate leukocyte subsets to the sites of inflammation... - Requirement for dendritic cells in the establishment of anti-phospholipid antibodiesAttilio Bondanza
H San Raffaele Scientific Institute, Universita Vita Salute, Milano, Italy
Autoimmunity 40:302-6. 2007..Little is known about the regulation of the immune response against soluble autoantigens targeted in these diseases... - Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanomaCristiana Perrotta
H San Raffaele Scientific Institute, Italy
Cancer Res 67:7559-64. 2007.... - The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophagesAndre P van Rossum
University Hospital Groningen, Groningen, The Netherlands
Arthritis Rheum 50:2667-74. 2004..We undertook this study to test our hypothesis that PTX3 inhibits phagocytosis of late apoptotic PMNs by macrophages, thereby leading to their accumulation in the vessel wall... - Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanomaCristiana Perrotta
Department of Pharmaco-Biology, University of Calabria, Rende
Cancer Res 64:3767-71. 2004..All of the effects of DETA-NO were mediated through cGMP generation. NO and NO-generating drugs may therefore be used to increase the anticancer efficacy of DCs...