Angelo A Manfredi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo
    Attilio Bondanza
    Clinical Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    J Exp Med 200:1157-65. 2004
  2. pmc The role of platelets in the pathogenesis of systemic sclerosis
    Giuseppe A Ramirez
    Department of Immunology, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Front Immunol 3:160. 2012
  3. ncbi request reprint Regulation of dendritic- and T-cell fate by injury-associated endogenous signals
    Angelo A Manfredi
    Vita Salute San Raffaele University and San Raffaele Scientific Institute, 20132 Milano, Italy
    Crit Rev Immunol 29:69-86. 2009
  4. ncbi request reprint Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes
    Angelo A Manfredi
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
    J Immunol 180:2270-5. 2008
  5. doi request reprint Dangerous connections: neutrophils and the phagocytic clearance of activated platelets
    Angelo A Manfredi
    San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Curr Opin Hematol 17:3-8. 2010
  6. ncbi request reprint Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
  7. doi request reprint Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis
    Norma Maugeri
    San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Autoimmunity 45:584-7. 2012
  8. doi request reprint High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Antioxid Redox Signal 15:2161-74. 2011
  9. ncbi request reprint Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells
    Sestina Falcone
    Vita Salute University and Stem Cell Research Institute, San Raffaele, Milan, Italy
    J Immunol 173:4452-63. 2004
  10. ncbi request reprint The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells
    Paramita Baruah
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 80:87-95. 2006

Detail Information

Publications68

  1. pmc Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo
    Attilio Bondanza
    Clinical Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    J Exp Med 200:1157-65. 2004
    ..Finally, AxV-coupled irradiated cells induced the regression of growing tumors. These data indicate that endogenous adjuvants that bind to dying tumor cells can be exploited to target tumors for immune rejection...
  2. pmc The role of platelets in the pathogenesis of systemic sclerosis
    Giuseppe A Ramirez
    Department of Immunology, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Front Immunol 3:160. 2012
    ..As a consistent circulating source of bioactive compounds platelets contribute to the development of many characteristic phenomena of SSc, such as fibrosis and impaired vascular tone...
  3. ncbi request reprint Regulation of dendritic- and T-cell fate by injury-associated endogenous signals
    Angelo A Manfredi
    Vita Salute San Raffaele University and San Raffaele Scientific Institute, 20132 Milano, Italy
    Crit Rev Immunol 29:69-86. 2009
    ....
  4. ncbi request reprint Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes
    Angelo A Manfredi
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
    J Immunol 180:2270-5. 2008
    ..Thus the HMGB1-RAGE pathway is a checkpoint in DC maturation and function and a candidate for targeted therapies...
  5. doi request reprint Dangerous connections: neutrophils and the phagocytic clearance of activated platelets
    Angelo A Manfredi
    San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Curr Opin Hematol 17:3-8. 2010
    ..We have summarized the evidence suggesting a homeostatic function of the interaction, culminating in the removal of activated platelets from the bloodstream...
  6. ncbi request reprint Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
    ..The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism...
  7. doi request reprint Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis
    Norma Maugeri
    San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Autoimmunity 45:584-7. 2012
    ..These findings indicate that platelets represent a source of HMGB1, an ancestral signal of necrosis, in the vasculature of SSc patients, possible contributing to persistent microvascular injury and endothelial cell activation...
  8. doi request reprint High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Antioxid Redox Signal 15:2161-74. 2011
    ..We propose that the early antioxidant response in regenerating muscle limits HMGB1 oxidation, thus allowing successful muscle regeneration...
  9. ncbi request reprint Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells
    Sestina Falcone
    Vita Salute University and Stem Cell Research Institute, San Raffaele, Milan, Italy
    J Immunol 173:4452-63. 2004
    ..Thus, A-SMase plays a central role in E. coli/LPS-induced DC apoptosis and its inhibition by NO, and it might be a target of new therapeutic approaches to sepsis...
  10. ncbi request reprint The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells
    Paramita Baruah
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 80:87-95. 2006
    ....
  11. doi request reprint Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury
    Lidia Bosurgi
    Division of Regenerative Medicine, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 188:6267-77. 2012
    ..Consequently, the treatment of muscle disorders with mesoangioblasts should take into consideration coexisting inflammatory pathways, whose activation may prove crucial for its success...
  12. ncbi request reprint The secretion of HMGB1 is required for the migration of maturing dendritic cells
    Ingrid E Dumitriu
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 81:84-91. 2007
    ..Our data suggest that the autocrine/paracrine release of HMGB1 and the integrity of the HMGB1/RAGE pathway are required for the migratory function of DC...
  13. ncbi request reprint Leukocyte HMGB1 is required for vessel remodeling in regenerating muscles
    Lara Campana
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 192:5257-64. 2014
    ..Altogether, our results reveal a novel nonredundant role for leukocyte Hmgb1 in the repair of injured skeletal muscle. ..
  14. ncbi request reprint TNF-alpha coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigens
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Scientific Institute and San Raffaele Vita Salute University, Milano, Italy
    J Immunol 172:2643-50. 2004
    ....
  15. doi request reprint Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
    Karine Lolmede
    Clinical Cardiovascular Biology Research Center, H San Raffaele Scientific Institute, Milano, Italy
    J Leukoc Biol 85:779-87. 2009
    ..Moreover, they open the possibility of novel strategies, aimed at interfering selectively with signals that recruit blood-derived stem cells toward pro- or anti-inflammatory macrophages...
  16. ncbi request reprint HMGB1: guiding immunity from within
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    Trends Immunol 26:381-7. 2005
    ..The role of HMGB1 as an endogenous molecule that facilitates immune responses and has an important role in tissue homeostasis and disease will be highlighted here...
  17. doi request reprint Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK/LAK cells
    Annalisa Capobianco
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
    J Immunother 31:458-65. 2008
    ..The response associated to the preferential recruitment within tumors of eosinophils. The simultaneous injection in solid tumors of DCs and NK/LAK cells represents an attractive approach for antineoplastic immunotherapeutic strategies...
  18. doi request reprint Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Milano, Italy
    Ann N Y Acad Sci 1209:83-90. 2010
    ..Moreover, data suggest a potential role for infiltrating alternatively activated macrophages to influence the outcome of inflammatory responses to sterile skeletal muscle necrosis...
  19. ncbi request reprint Requirement of dying cells and environmental adjuvants for the induction of autoimmunity
    Attilio Bondanza
    H San Raffaele Scientific Institute and University, Via Olgettina 58, Milan 20132, Italy
    Arthritis Rheum 50:1549-60. 2004
    ..However, dying cells are a potential initiating stimulus for systemic lupus erythematosus (SLE). Our goal was to verify whether immune adjuvants influence the autoimmunity induction that ensues following in vivo injection of dying cells...
  20. ncbi request reprint Anti-inflammatory action of apoptotic cells in patients with acute coronary syndromes
    Luca A Ferri
    Istituto Scientifico San Raffaele and Università Vita Salute San Raffaele, Milan, Italy
    Atherosclerosis 205:391-5. 2009
    ..Atherosclerotic plaques contain both apoptotic cells and phagocytes. Apoptotic cells are known to exert an anti-inflammatory effect. Little is known on their action in patients with acute coronary syndromes...
  21. doi request reprint Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and {beta}2 integrin-dependent cell clearance program
    Norma Maugeri
    H San Raffaele Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Blood 113:5254-65. 2009
    ..The data suggest that the interaction between circulating platelets and neutrophils influences innate immune functions, possibly contributing to regulate vascular inflammation...
  22. ncbi request reprint Leukocyte and platelet activation in patients with giant cell arteritis and polymyalgia rheumatica: a clue to thromboembolic risks?
    Norma Maugeri
    San Raffaele Scientific Institute, University of Vita Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy
    Autoimmunity 42:386-8. 2009
    ..Activated circulating leukocytes and platelets could contribute to indolent vessel inflammation and possibly to thromboembolic events in patients with systemic large vessel vasculitis...
  23. doi request reprint Expansion of T-cell receptor zeta dim effector T cells in acute coronary syndromes
    Enrico Ammirati
    Clinical Cardiovascular Biology Research Centre, Vita Salute San Raffaele University and San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Arterioscler Thromb Vasc Biol 28:2305-11. 2008
    ..We assessed the expression and functional correlates of circulating TCR zeta(dim) T cells in coronary artery disease...
  24. doi request reprint Circulating chromogranin A reveals extra-articular involvement in patients with rheumatoid arthritis and curbs TNF-alpha-elicited endothelial activation
    Gabriele Di Comite
    Department of Medicine, Oncology and Clinical Immunology Unit, H San Raffaele University Hospital, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    J Leukoc Biol 85:81-7. 2009
    ..Our results suggest that enhanced levels of CgA identify patients with extra-articular involvement and reveal a negative feedback loop that limits the activation of endothelial cells in RA...
  25. doi request reprint Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis
    Enrico Ammirati
    Clinical Cardiovascular Biology Research Centre, San Raffaele Scientific Institute and the Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Arterioscler Thromb Vasc Biol 30:1832-41. 2010
    ..Regulatory T (Treg) cells play a protective role in experimental atherosclerosis. In the present study, we investigated whether the levels of circulating Treg cells relate to the degree of atherosclerosis in carotid and coronary arteries...
  26. pmc Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage
    Elena Rigamonti
    Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 190:1767-77. 2013
    ..To our knowledge, these data thus provide the first evidence that iNOS expression by infiltrating macrophages contributes to muscle regeneration, revealing a novel mechanism of inflammation-dependent muscle healing...
  27. ncbi request reprint Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells
    Ingrid E Dumitriu
    H San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 35:2184-90. 2005
    ..These results reveal HMGB1 and RAGE as the first known autocrine loop modulating the maturation of PDC, and suggest that antagonists of HMGB1/RAGE might have therapeutic potential for the treatment of systemic human diseases...
  28. pmc Magnetic resonance imaging at 7T reveals common events in age-related sarcopenia and in the homeostatic response to muscle sterile injury
    Antonio Esposito
    Department of Radiology and Preclinical MR and US Facility of Experimental Imaging Center, San Raffaele Scientific Institute, Milano, Italy
    PLoS ONE 8:e59308. 2013
    ..A. as common events reflecting inflammatory infiltration and muscle regeneration in the transient response of the tissue to acute injury and in the persistent adaptation to aging...
  29. ncbi request reprint Melanoma cells interfere with the interaction of dendritic cells with NK/LAK cells
    Annalisa Capobianco
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milano, Italy
    Int J Cancer 119:2861-9. 2006
    ..Interference with the NK/DC interaction possibly represents a mechanism used by growing tumors to evade the immune response...
  30. ncbi request reprint Requirement for dendritic cells in the establishment of anti-phospholipid antibodies
    Attilio Bondanza
    H San Raffaele Scientific Institute, Universita Vita Salute, Milano, Italy
    Autoimmunity 40:302-6. 2007
    ..Little is known about the regulation of the immune response against soluble autoantigens targeted in these diseases...
  31. doi request reprint Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases
    Norma Maugeri
    Autoimmunity and Vascular Inflammation Unit, University Vita Salute San Raffaele and San Raffaele Scientific Institute, Milan, Italy
    Thromb Res 129:267-73. 2012
    ..Here we will discuss the implications of these results for the pathogenesis and the clinical features of self-sustaining immune-mediated vessel diseases...
  32. doi request reprint Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia
    Norma Maugeri
    Unit of Autoimmunity and Vascular Inflammation, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Istituto Scientifico San Raffaele and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 118:3359-66. 2011
    ....
  33. ncbi request reprint Innate responses to Aspergillus: role of C1q and pentraxin 3 in nasal polyposis
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano, Italy
    Am J Rhinol 21:224-30. 2007
    ....
  34. ncbi request reprint High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    Marco E Bianchi
    Faculty of Medicine, San Raffaele University, Milano, Italy
    Immunol Rev 220:35-46. 2007
    ..These immune responses will also be directed against self-antigens that DCs process at the time of injury and can lead to autoimmunity...
  35. ncbi request reprint Characterisation of functional biotinylated TNF-alpha targeted to the membrane of apoptotic melanoma cells
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Programme, H San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    J Immunol Methods 276:79-87. 2003
    ..Therefore the bridging of TNF-alpha potentiates its biological function and influences the outcome of the phagocytic clearance of apoptotic tumor cells...
  36. ncbi request reprint Efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients
    Enrica P Bozzolo
    Unit of Medicine and Clinical Immunology, Department of Medicine, 20132 Milano, Italy
    Autoimmunity 46:537-46. 2013
    ..To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients...
  37. pmc 7-Tesla magnetic resonance imaging precisely and noninvasively reflects inflammation and remodeling of the skeletal muscle in a mouse model of antisynthetase syndrome
    Clara Sciorati
    Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Biomed Res Int 2014:879703. 2014
    ..Thus, MR imaging represents an informative and noninvasive analytical tool for studying in vivo immune-mediated muscle involvement. ..
  38. pmc Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    PLoS ONE 4:e5959. 2009
    ..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs...
  39. ncbi request reprint Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunity
    Patrizia Rovere-Querini
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Autoimmunity 40:290-4. 2007
    ....
  40. doi request reprint Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia
    Mattia Baldini
    Istituto Scientifico San Raffaele and Università Vita Salute San Raffaele, Milan, Italy
    Arthritis Rheum 64:854-65. 2012
    ..To assess local expression and plasma levels of pentraxin 3 (PTX3) in patients with giant cell arteritis (GCA)...
  41. pmc Polarization dictates iron handling by inflammatory and alternatively activated macrophages
    Gianfranca Corna
    H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    Haematologica 95:1814-22. 2010
    ..Little is known on whether the polarization program influences the ability of macrophages to store or recycle iron and the molecular machinery involved in the processes...
  42. pmc An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes
    Norma Maugeri
    Università Vita Salute San Raffaele and San Raffaele Scientific Institute, Milano, Italy
    PLoS ONE 7:e39484. 2012
    ..Neutrophils are involved in thrombus formation. We investigated whether specific features of neutrophil activation characterize patients with acute coronary syndromes (ACS) compared to stable angina and to systemic inflammatory diseases...
  43. pmc HMGB1 is an endogenous immune adjuvant released by necrotic cells
    Patrizia Rovere-Querini
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milano, Italy
    EMBO Rep 5:825-30. 2004
    ..In vivo, HMGB1 enhances the primary antibody responses to soluble antigens and transforms poorly immunogenic apoptotic lymphoma cells into efficient vaccines...
  44. ncbi request reprint The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
    Blood 107:151-8. 2006
    ..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells...
  45. ncbi request reprint Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia
    Patrizia Rovere-Querini
    Clinical Immunology Unit, Division of Pathology, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
    Obstet Gynecol 108:148-55. 2006
    ..We examined whether PTX3 is expressed during pregnancy and possibly involved in the development of preeclampsia...
  46. doi request reprint Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity
    Barbara Valentinis
    MolMed S p A, Via Olgettina 58, 20132 Milan, Italy
    J Leukoc Biol 84:199-206. 2008
    ..No activation of p38 was induced in the same experimental conditions. Our data suggest that the IkappaB-alpha/NF-kappaB pathway has a critical role in the partial maturation of DCs induced by rHSP70...
  47. doi request reprint Pentraxins, humoral innate immunity and tissue injury
    Angelo A Manfredi
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milan 20132, Italy
    Curr Opin Immunol 20:538-44. 2008
    ....
  48. ncbi request reprint Cell death: tipping the balance of autoimmunity and tissue repair
    Patrizia Rovere-Querini
    H San Raffaele Scientific Institute, 20132 Milano, Italy
    Curr Pharm Des 14:269-77. 2008
    ....
  49. ncbi request reprint Cutting edge: dissociation between autoimmune response and clinical disease after vaccination with dendritic cells
    Attilio Bondanza
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology and Rheumatology Unit, H San Raffaele Scientific Institute, and Universita Vita Salute San Raffaele, Milan, Italy
    J Immunol 170:24-7. 2003
    ..The data suggest that DC vaccination consistently triggers autoimmune responses. However, clinical autoimmunity develops in susceptible subjects only...
  50. doi request reprint Oxidative stress elicits platelet/leukocyte inflammatory interactions via HMGB1: a candidate for microvessel injury in sytemic sclerosis
    Norma Maugeri
    1 Division of Regenerative Medicine, Stem Cells and Gene Therapy, and Department of Medicine, San Raffaele Scientific Institute, Milano, Italy
    Antioxid Redox Signal 20:1060-74. 2014
    ..Here we investigate whether oxidative stress regulates the cross-talk between leukocytes and platelets via HMGB1, thus contributing to vessel inflammation in SSc...
  51. doi request reprint Pregnancy outcomes in patients with systemic autoimmunity
    Valentina Canti
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Autoimmunity 45:169-75. 2012
    ..Results confirm that a strict follow-up and targeted treatments significantly improve pregnancy outcomes in autoimmune patients with PAPS, SLE and isolated autoAbs. The pregnancy outcome in patients with APS/SLE remains unsatisfactory...
  52. ncbi request reprint Environmental adjuvants, apoptosis and the censorship over autoimmunity
    Patrizia Rovere-Querini
    H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    Autoimmun Rev 4:555-60. 2005
    ..Novel tools for drug development will derive from the molecular identification of the constraints that prevent autoimmunity in normal subjects...
  53. doi request reprint Pentraxin-3 as a marker of disease activity in Takayasu arteritis
    Lorenzo Dagna
    Vita Salute San Raffaele University School of Medicine and San Raffaele Scientific Institute, Milano, Italy
    Ann Intern Med 155:425-33. 2011
    ..Because pentraxin-3 (PTX3) is produced by immune and vascular cells in response to proinflammatory signals, it may be a useful biomarker for defining disease activity in patients with Takayasu arteritis...
  54. doi request reprint Evaluation of the role of tumor-associated macrophages in an experimental model of peritoneal carcinomatosis using (18)F-FDG PET
    Lucia Cottone
    Autoimmunity and Vascular Inflammation Unit, San Raffaele Scientific Institute, Milan, Italy
    J Nucl Med 52:1770-7. 2011
    ..Here, we established and took advantage of a preclinical model of peritoneal carcinomatosis to evaluate the contribution of inflammatory infiltrating macrophages in tumor progression that was followed using (18)F-FDG PET...
  55. pmc Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models
    Enrico Ammirati
    Clinical Cardiovascular Biology Centre, San Raffaele Scientific Institute and the Università Vita Salute San Raffaele, Milan, Italy E A, D C, M B Heart Transplantation Division, Ospedale Niguarda Ca Granda, Milan, Italy E A Heart Care Foundation, Florence, Italy E A, A M
    J Am Heart Assoc 1:27-41. 2012
    ..J Am Heart Assoc. 2012;1:27-41.)...
  56. pmc Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease
    Annalisa Capobianco
    Autoimmunity and Vascular Inflammation Unit, San Raffaele Scientific Institute, Milan, Italy
    Am J Pathol 179:2651-9. 2011
    ..Thus, TEMs are important for maintaining the viability of newly formed vessels and represent a potential therapeutic target in endometriosis...
  57. ncbi request reprint Clinical and experimental evidences on the prothrombotic properties of neutrophils
    Norma Maugeri
    San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milano, Italy
    Srp Arh Celok Lek 138:50-2. 2010
    ....
  58. ncbi request reprint Conversation galante: how the immune and the neuroendocrine systems talk to each other
    Gabriele Di Comite
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Autoimmun Rev 7:23-9. 2007
    ..A better molecular dissection of this finely regulated inter-system cross-talk, in physiological conditions and during self-sustaining inflammatory diseases, might enable more rational therapeutic approaches...
  59. doi request reprint Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010
    ..Thus, HMGB1-TLR4 signaling may contribute to generating and perpetuating seizures in humans and might be targeted to attain anticonvulsant effects in epilepsies that are currently resistant to drugs...
  60. ncbi request reprint Synergism of nitric oxide and maturation signals on human dendritic cells occurs through a cyclic GMP-dependent pathway
    Clara Paolucci
    Department Neuroscience, DIBIT H San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
    J Leukoc Biol 73:253-62. 2003
    ..These results provide the first evidence that NO acts as a cosignaling molecule regulating human DC response to maturation stimuli...
  61. ncbi request reprint Double-edged effect of Vgamma9/Vdelta2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection
    Priscilla Biswas
    Laboratory of Clinical Immunology, Scientific Institute H S Raffaele, Milan, Italy
    Eur J Immunol 33:252-63. 2003
    ..Thus, we suggest that specific recognition of mycobacterial Ag by gamma delta T lymphocytes in co-infected individuals may modulate viral replication through the complex array of soluble factors released...
  62. doi request reprint High-mobility group box 1 (HMGB1) as a master regulator of innate immunity
    Alessandra Castiglioni
    Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Via Olgettina 58, 20132 Milan, Italy
    Cell Tissue Res 343:189-99. 2011
    ..Evidence suggests that HMGB1 acts as a key molecule of innate immunity, downstream of persistent tissue injury, orchestrating inflammation, stem cell recruitment/activation, and eventual tissue remodeling...
  63. ncbi request reprint Tumor destruction and in situ delivery of antigen presenting cells promote anti-neoplastic immune responses: implications for the immunotherapy of pancreatic cancer
    Patrizia Rovere-Querini
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Vita Salute San Raffaele University Milan, Italy
    JOP 5:308-14. 2004
    ....
  64. ncbi request reprint Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes
    Lorenzo Dagna
    Laboratory of Tumor Immunology, Department of Medicine, Scientific Institute H San Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Eur J Immunol 32:2934-43. 2002
    ..Overall, our data suggest that type-2 differentiation of gamma delta T lymphocytes profoundly affects both their effector functions and their potential to recruit the appropriate leukocyte subsets to the sites of inflammation...
  65. ncbi request reprint Dendritic cells and the shadow line between autoimmunity and disease
    Angelo A Manfredi
    Arthritis Rheum 52:11-5. 2005
  66. ncbi request reprint Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma
    Cristiana Perrotta
    Department of Pharmaco Biology, University of Calabria, Rende
    Cancer Res 64:3767-71. 2004
    ..All of the effects of DETA-NO were mediated through cGMP generation. NO and NO-generating drugs may therefore be used to increase the anticancer efficacy of DCs...
  67. ncbi request reprint Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma
    Cristiana Perrotta
    H San Raffaele Scientific Institute, Italy
    Cancer Res 67:7559-64. 2007
    ....
  68. ncbi request reprint The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages
    Andre P van Rossum
    University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 50:2667-74. 2004
    ..We undertook this study to test our hypothesis that PTX3 inhibits phagocytosis of late apoptotic PMNs by macrophages, thereby leading to their accumulation in the vessel wall...