Cristina Lorenzi

Summary

Affiliation: San Raffaele Foundation, Clinical Neuroscience Dept- S. Raffaele-Turro Hospital
Location: Milan, Italy
URL: http://www.sanraffaele.org/Home/index.html
Summary:
1998-1999 Post doctoral fellow for Sacred Heart Hospital - FateBeneFratelli - IRCCS, Brescia, Italy (place of research activity: Dept. of Neuropsychiatric Sciences University of Milan, IRCCS Ospedale S.Raffaele, Milan).
1999-2000 Post doctoral -. Research fellow - "Centro Studi Gabriella Sciuto per la ricerca biologica nei disturbi d
Publications:
1] Benedetti F, Barbini B, Bernasconi A, Fulgosi MC, Dallaspezia S, Gavinelli C, Locatelli C, Lorenzi C, Pirovano A, Radaelli D, Smeraldi E, Colombo C Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord 121, 68-72.
[2] Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine. Eur Psychiatry 25, 476-478.
[3] Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. J Affect Disord 125, 341-344.
[4] Benedetti F, Dallaspezia S, Locatelli C, Radaelli D, Poletti S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord 132, 293-296.
[5] Benedetti F, Poletti S, Radaelli D, Bernasconi A, Cavallaro R, Falini A, Lorenzi C, Pirovano A, Dallaspezia S, Locatelli C, Scotti G, Smeraldi E Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-beta activity. Genes Brain Behav 9, 365-371.
[6] Benedetti F, Radaelli D, Poletti S, Locatelli C, Dallaspezia S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression. J Affect Disord 132, 297-300.
[7] Bosia M, Anselmetti S, Bechi M, Lorenzi C, Pirovano A, Cocchi F, Buonocore M, Bramanti P, Smeraldi E, Cavallaro R Effect of 5-HT1A-receptor functional polymorphism on Theory of Mind performances in schizophrenia. Psychiatry Res 188, 187-190.
[8] Dallaspezia S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E, Benedetti F Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder. Eur Psychiatry 26, 138-140.
[9] Lorenzi C, Delmonte D, Pirovano A, Marino E, Bongiorno F, Catalano M, Colombo C, Bramanti P, Smeraldi E Searching susceptibility loci for bipolar disorder: a sib pair study on chromosome 12. Neuropsychobiology 61, 10-18.
[10] Lorenzi C, Marcone A, Pirovano A, Marino E, Cordici F, Cerami C, Delmonte D, Cappa SF, Bramanti P, Smeraldi E Serotonin transporter and saitohin genes in risk of Alzheimers disease and frontotemporal lobar dementia: preliminary findings. Neurol Sci 31, 741-749.
[11] Marino E, Fanny B, Lorenzi C, Pirovano A, Franchini L, Colombo C, Bramanti P, Smeraldi E Genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene. Neurol Sci 31, 387-391.
[12] Serretti A, Lilli R, Lorenzi C, Franchini L, Smeraldi E (1998) Dopamine receptor D3 gene and response to lithium prophylaxis in mood disorders. Int J Neuropsychopharmacol 1, 125-129.
[13] Serretti A, Benedetti F, Colombo C, Lilli R, Lorenzi C, Smeraldi E (1999) Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation. Psychiatry Res 89, 107-114.
[14] Serretti A, Cusin C, Lattuada E, Lilli R, Lorenzi C, Di Bella D, Catalano M, Smeraldi E (1999) No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses. Am J Med Genet 88, 481-485.
[15] Serretti A, Lattuada E, Cusin C, Lilli R, Lorenzi C, Smeraldi E (1999) Dopamine D3 receptor gene not associated with symptomatology of major psychoses. Am J Med Genet 88, 476-480.
[16] Serretti A, Lilli R, Lorenzi C, Franchini L, Di Bella D, Catalano M, Smeraldi E (1999) Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. Psychiatry Res 87, 7-19.
[17] Serretti A, Lilli R, Lorenzi C, Gasperini M, Smeraldi E (1999) Tryptophan hydroxylase gene and response to lithium prophylaxis in mood disorders. J Psychiatr Res 33, 371-377.
[18] Serretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E (1999) Lack of association between tryptophan hydroxylase gene and psychotic symptomatology in schizophrenia. Schizophr Res 40, 171-172.
[19] Serretti A, Lilli R, Lorenzi C, Smeraldi E (1999) No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders. Psychiatry Res 86, 203-209.
[20] Serretti A, Cusin C, Lorenzi C, Lattuada E, Lilli R, Smeraldi E (2000) Serotonin-2A receptor gene is not associated with symptomatology of schizophrenia. Am J Med Genet 96, 84-87.
[21] Serretti A, Lattuada E, Lorenzi C, Lilli R, Smeraldi E (2000) Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses. Mol Psychiatry 5, 270-274.
[22] Serretti A, Lilli R, Lorenzi C, Lattuada E, Smeraldi E (2000) Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders. Am J Med Genet 96, 161-166.
[23] Serretti A, Lilli R, Lorenzi C, Smeraldi E (2000) Further evidence supporting the association between the dopamine receptor D2 Ser/Cys311 variant and disorganized symptomatology of schizophrenia. Schizophr Res 43, 161-162.
[24] Serretti A, Lorenzi C, Lilli R, Smeraldi E (2000) Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders. J Psychiatr Res 34, 89-98.
[25] Cusin C, Serretti A, Lattuada E, Lilli R, Lorenzi C, Mandelli L, Pisati E, Smeraldi E (2001) Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. J Psychiatr Res 35, 217-223.
[26] Serretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E (2001) Tryptophan hydroxylase gene and major psychoses. Psychiatry Res 103, 79-86.
[27] Serretti A, Lilli R, Lorenzi C, Lattuada E, Smeraldi E (2001) DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: a study on 2,011 affected subjects. Am J Med Genet 105, 283-290.
[28] Serretti A, Lilli R, Mandelli L, Lorenzi C, Smeraldi E (2001) Serotonin transporter gene associated with lithium prophylaxis in mood disorders. Pharmacogenomics J 1, 71-77.
[29] Serretti A, Zanardi R, Cusin C, Rossini D, Lilli R, Lorenzi C, Lattuada E, Smeraldi E (2001) No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors. Psychiatry Res 104, 195-203.
[30] Serretti A, Zanardi R, Cusin C, Rossini D, Lorenzi C, Smeraldi E (2001) Tryptophan hydroxylase gene associated with paroxetine antidepressant activity. Eur Neuropsychopharmacol 11, 375-380.
[31] Catalano M, Lorenzi C, Bocchio L, Racagni G (2002) No occurrence of the glutamate transporter EAAT2 A206G polymorphism in schizophrenic subjects. Mol Psychiatry 7, 671-672.
[32] Cusin C, Serretti A, Lattuada E, Lilli R, Lorenzi C, Smeraldi E (2002) Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders. Am J Med Genet 114, 380-390.
[33] Cusin C, Serretti A, Zanardi R, Lattuada E, Rossini D, Lilli R, Lorenzi C, Smeraldi E (2002) Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity. Int J Neuropsychopharmacol 5, 27-35.
[34] Serretti A, Cristina S, Lilli R, Cusin C, Lattuada E, Lorenzi C, Corradi B, Grieco G, Costa A, Santorelli F, Barale F, Nappi G, Smeraldi E (2002) Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. Am J Med Genet 114, 361-369.
[35] Serretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E (2002) Serotonin transporter gene (5-HTTLPR) and major psychoses. Mol Psychiatry 7, 95-99.
[36] Serretti A, Lorenzi C, Lilli R, Mandelli L, Pirovano A, Smeraldi E (2002) Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants. Am J Med Genet 114, 370-379.
[37] Benedetti F, Colombo C, Serretti A, Lorenzi C, Pontiggia A, Barbini B, Smeraldi E (2003) Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biol Psychiatry 54, 687-692.
[38] Benedetti F, Serretti A, Colombo C, Barbini B, Lorenzi C, Campori E, Smeraldi E (2003) Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. Am J Med Genet B Neuropsychiatr Genet 123B, 23-26.
[39] Benedetti F, Serretti A, Colombo C, Lilli R, Lorenzi C, Smeraldi E (2003) Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression. Psychiatry Res 118, 241-247.
[40] Chotai J, Serretti A, Lattuada E, Lorenzi C, Lilli R (2003) Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms. Psychiatry Res 119, 99-111.
[41] Domschke K, Kuhlenbaumer G, Schirmacher A, Lorenzi C, Armengol L, DiBella D, Gratacos M, Garritsen HS, Nothen MM, Franke P, Sand P, Fritze J, Perez G, Maier W, Sibrowski W, Estivill X, Bellodi L, Ringelstein EB, Arolt V, Martin-Santos R, Catalano M, Stogbauer F, Deckert J (2003) Human nuclear transcription factor gene CREM: genomic organization, mutation screening, and association analysis in panic disorder. Am J Med Genet B Neuropsychiatr Genet 117B, 70-78.
[42] Serretti A, Benedetti F, Mandelli L, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2003) Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 121B, 35-38.
[43] Serretti A, Cusin C, Cristina S, Lorenzi C, Lilli R, Lattuada E, Grieco G, Costa A, Santorelli F, Barale F, Smeraldi E, Nappi G (2003) Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders. Psychiatr Genet 13, 121-126.
[44] Serretti A, Lorenzi C, Cusin C, Zanardi R, Lattuada E, Rossini D, Lilli R, Pirovano A, Catalano M, Smeraldi E (2003) SSRIs antidepressant activity is influenced by G beta 3 variants. Eur Neuropsychopharmacol 13, 117-122.
[45] Benedetti F, Bernasconi A, Lorenzi C, Pontiggia A, Serretti A, Colombo C, Smeraldi E (2004) A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder. Neurosci Lett 355, 37-40.
[46] Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E (2004) A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368, 123-126.
[47] Lattuada E, Cavallaro R, Benedetti F, Cocchi F, Lorenzi C, Smeraldi E (2004) Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness. Neurosci Lett 367, 152-155.
[48] Lattuada E, Cavallaro R, Serretti A, Lorenzi C, Smeraldi E (2004) Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment. Int J Neuropsychopharmacol 7, 489-493.
[49] Mendlewicz J, Massat I, Souery D, Del-Favero J, Oruc L, Nothen MM, Blackwood D, Muir W, Battersby S, Lerer B, Segman RH, Kaneva R, Serretti A, Lilli R, Lorenzi C, Jakovljevic M, Ivezic S, Rietschel M, Milanova V, Van Broeckhoven C (2004) Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. Eur J Hum Genet 12, 377-382.
[50] Serretti A, Artioli P, Lorenzi C, Pirovano A, Tubazio V, Zanardi R (2004) The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. Int J Neuropsychopharmacol 7, 453-460.
[51] Serretti A, Artioli P, Zanardi R, Lorenzi C, Rossini D, Cusin C, Arnoldi A, Catalano M (2004) Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder. Psychopharmacology (Berl) 174, 504-511.
[52] Serretti A, De Ronchi D, Lorenzi C, Berardi D (2004) New antipsychotics and schizophrenia: a review on efficacy and side effects. Curr Med Chem 11, 343-358.
[53] Serretti A, Lorenzi C, Mandelli L, Cichon S, Schumacher J, Nothen MM, Rietschel M, Tullius M, Ohlraun S (2004) DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population. Neurosci Lett 368, 269-273.
[54] Serretti A, Malitas PN, Mandelli L, Lorenzi C, Ploia C, Alevizos B, Nikolaou C, Boufidou F, Christodoulou GN, Smeraldi E (2004) Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders. Pharmacogenomics J 4, 267-273.
[55] Benedetti F, Serretti A, Pontiggia A, Bernasconi A, Lorenzi C, Colombo C, Smeraldi E (2005) Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP. Neurosci Lett 376, 51-55.
[56] Chotai J, Serretti A, Lorenzi C (2005) Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders. Neuropsychobiology 51, 3-9.
[57] Lorenzi C, Mandelli L, Pirovano A, Ploia C, Insacco C, Serretti A (2005) The XIIth World Congress of Psychiatric Genetics. October 9-13, 2004, Dublin, Ireland. Pharmacogenomics 6, 199-204.
[58] Lorenzi C, Serretti A, Mandelli L, Tubazio V, Ploia C, Smeraldi E (2005) 5-HT 1A polymorphism and self-transcendence in mood disorders. Am J Med Genet B Neuropsychiatr Genet 137B, 33-35.
[59] Massat I, Souery D, Del-Favero J, Nothen M, Blackwood D, Muir W, Kaneva R, Serretti A, Lorenzi C, Rietschel M, Milanova V, Papadimitriou GN, Dikeos D, Van Broekhoven C, Mendlewicz J (2005) Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry 10, 598-605.
[60] Pirovano A, Lorenzi C, Serretti A, Ploia C, Landoni S, Catalano M, Smeraldi E (2005) Two new rare variants in the circadian "clock" gene may influence sleep pattern. Genet Med 7, 455-457.
[61] Serretti A, Mandelli L, Lorenzi C, Smeraldi E (2005) Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects. Psychiatry Res 134, 191-194.
[62] Arias B, Serretti A, Lorenzi C, Gasto C, Catalan R, Fananas L (2006) Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin. J Affect Disord 90, 251-256.
[63] Dikeos DG, Papadimitriou GN, Souery D, Del-Favero J, Massat I, Blackwood D, Cichon S, Daskalopoulou E, Ivezic S, Kaneva R, Karadima G, Lorenzi C, Milanova V, Muir W, Nothen M, Oruc L, Rietschel M, Serretti A, Van Broeckhoven C, Soldatos CR, Stefanis CN, Mendlewicz J (2006) Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study. Psychiatr Genet 16, 169-171.
[64] Serretti A, Mandelli L, Lorenzi C, Landoni S, Calati R, Insacco C, Cloninger CR (2006) Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology 53, 9-16.
[65] Serretti A, Rotondo A, Lorenzi C, Smeraldi E, Cassano GB (2006) Catechol-O-methyltransferase gene variants in mood disorders in the Italian population. Psychiatr Genet 16, 181-182.
[66] Smeraldi E, Serretti A, Artioli P, Lorenzi C, Catalano M (2006) Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants. Psychiatr Genet 16, 153-158.
[67] Artioli P, Lorenzi C, Pirovano A, Serretti A, Benedetti F, Catalano M, Smeraldi E (2007) How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes. Eur Neuropsychopharmacol 17, 587-594.
[68] Benedetti F, Bernasconi A, Blasi V, Cadioli M, Colombo C, Falini A, Lorenzi C, Radaelli D, Scotti G, Smeraldi E (2007) Neural and genetic correlates of antidepressant response to sleep deprivation: a functional magnetic resonance imaging study of moral valence decision in bipolar depression. Arch Gen Psychiatry 64, 179-187.
[69] Benedetti F, Dallaspezia S, Fulgosi MC, Lorenzi C, Serretti A, Barbini B, Colombo C, Smeraldi E (2007) Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. Am J Med Genet B Neuropsychiatr Genet 144B, 631-635.
[70] Muller DJ, Serretti A, Sicard T, Tharmalingam S, King N, Artioli P, Mandelli L, Lorenzi C, Kennedy JL (2007) Further evidence of MAO-A gene variants associated with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 144B, 37-40.
[71] Serretti A, Mandelli L, Lorenzi C, Pirovano A, Olgiati P, Colombo C, Smeraldi E (2007) Serotonin transporter gene influences the time course of improvement of "core" depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders. Psychiatry Res 149, 185-193.
[72] Zanardi R, Magri L, Rossini D, Malaguti A, Giordani S, Lorenzi C, Pirovano A, Smeraldi E, Lucca A (2007) Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression. Eur Neuropsychopharmacol 17, 651-657.
[73] Benedetti F, Barbini B, Bernasconi A, Fulgosi MC, Campori E, Colombo C, Dallaspezia S, Lorenzi C, Pontiggia A, Radaelli D, Smeraldi E (2008) Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation. J Clin Psychopharmacol 28, 249-251.
[74] Benedetti F, Radaelli D, Bernasconi A, Dallaspezia S, Falini A, Scotti G, Lorenzi C, Colombo C, Smeraldi E (2008) Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients. Genes Brain Behav 7, 20-25.
[75] Serretti A, Benedetti F, Mandelli L, Calati R, Caneva B, Lorenzi C, Fontana V, Colombo C, Smeraldi E (2008) Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders. Psychiatry Res 158, 132-140.

Publications

  1. ncbi Serotonin transporter gene associated with lithium prophylaxis in mood disorders
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Pharmacogenomics J 1:71-7. 2001
  2. doi Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine
    F Benedetti
    Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele, University Vita Salute San Raffaele, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    Eur Psychiatry 25:476-8. 2010
  3. ncbi Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin
    Bárbara Arias
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Affect Disord 90:251-6. 2006
  4. ncbi Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Neuropsychobiology 53:9-16. 2006
  5. ncbi Two new rare variants in the circadian "clock" gene may influence sleep pattern
    Adele Pirovano
    Genet Med 7:455-7. 2005
  6. ncbi The XIIth World Congress of Psychiatric Genetics. October 9-13, 2004, Dublin, Ireland
    Cristina Lorenzi
    Vita Salute University, Department of Psychiatry, San Raffaele Institute, via Stamira D Ancona, 20 20127 Milan, Italy
    Pharmacogenomics 6:199-204. 2005
  7. ncbi 5-HT 1A polymorphism and self-transcendence in mood disorders
    Cristina Lorenzi
    Department of Psychiatry P Ottonello Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:33-5. 2005
  8. ncbi Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, San Raffaele Institute, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 134:191-4. 2005
  9. ncbi Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, San Raffaele Turro, 20127 Milano, Italy
    Neurosci Lett 376:51-5. 2005
  10. ncbi Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders
    Jayanti Chotai
    Division of Psychiatry, Department of Clinical Sciences, University of Umea, Umea, Sweden
    Neuropsychobiology 51:3-9. 2005

Detail Information

Publications64

  1. ncbi Serotonin transporter gene associated with lithium prophylaxis in mood disorders
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Pharmacogenomics J 1:71-7. 2001
    ..5-HTTLPR variants may be a possible influencing factor for the prophylactic efficacy of lithium in mood disorders...
  2. doi Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine
    F Benedetti
    Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele, University Vita Salute San Raffaele, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    Eur Psychiatry 25:476-8. 2010
    ..Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine and paroxetine, but several other studies were negative. No study considered drug plasma levels as possible nuisance covariate...
  3. ncbi Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin
    Bárbara Arias
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Affect Disord 90:251-6. 2006
    ..The COMT gene might be a good candidate for explaining some aspects of the pharmacological response to SSRIs...
  4. ncbi Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Neuropsychobiology 53:9-16. 2006
    ....
  5. ncbi Two new rare variants in the circadian "clock" gene may influence sleep pattern
    Adele Pirovano
    Genet Med 7:455-7. 2005
  6. ncbi The XIIth World Congress of Psychiatric Genetics. October 9-13, 2004, Dublin, Ireland
    Cristina Lorenzi
    Vita Salute University, Department of Psychiatry, San Raffaele Institute, via Stamira D Ancona, 20 20127 Milan, Italy
    Pharmacogenomics 6:199-204. 2005
  7. ncbi 5-HT 1A polymorphism and self-transcendence in mood disorders
    Cristina Lorenzi
    Department of Psychiatry P Ottonello Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:33-5. 2005
    ..Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait...
  8. ncbi Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, San Raffaele Institute, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 134:191-4. 2005
    ..However, we observed how the s/s variant, commonly associated with detrimental effects, could be beneficial in specific areas of social adjustment...
  9. ncbi Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, San Raffaele Turro, 20127 Milano, Italy
    Neurosci Lett 376:51-5. 2005
    ....
  10. ncbi Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders
    Jayanti Chotai
    Division of Psychiatry, Department of Clinical Sciences, University of Umea, Umea, Sweden
    Neuropsychobiology 51:3-9. 2005
    ....
  11. ncbi Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 10:598-605. 2005
    ..The COMT gene may have complex and pleiotropic effects on susceptibility and symptomatology of neuropsychiatric disorders...
  12. ncbi The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Int J Neuropsychopharmacol 7:453-60. 2004
    ..In conclusion, 5-HT1A variants could influence the antidepressant efficacy in bipolar subjects, even if results must be verified on larger samples...
  13. ncbi Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment
    Enrico Lattuada
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute, Vita Salute University School of Medicine, Milan, Italy
    Int J Neuropsychopharmacol 7:489-93. 2004
    ..017). An association trend was observed between the 'short' variant of DRD4 and TD (p=0.022). We did not observe any significant association for the DRD2 and DRD3 polymorphisms...
  14. ncbi DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
    Neurosci Lett 368:269-73. 2004
    ..However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy...
  15. ncbi A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milano, Italy
    Neurosci Lett 368:123-6. 2004
    ....
  16. ncbi Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants
    Enrico Smeraldi
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
    Psychiatr Genet 16:153-8. 2006
    ..These results, although very preliminary, can represent a further step toward a better understanding of the molecular genetics of antidepressant response...
  17. ncbi Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study
    Dimitris G Dikeos
    Department of Psychiatry, Athens University Medical School and University Mental Health Research Institute, Greece, and Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Psychiatr Genet 16:169-71. 2006
    ..On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder...
  18. ncbi Further evidence of MAO-A gene variants associated with bipolar disorder
    Daniel J Muller
    Department of Psychiatry, Charite University Medicine Berlin, PUK der Charité im SHK, Charite Campus Mitte, Berlin, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:37-40. 2007
    ..No different results were detected when analyzing female subjects separately. In conclusion, our family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder...
  19. doi Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Affect Disord 125:341-4. 2010
    ..Previous studies in bipolar patients reported non-significant trends in the same direction...
  20. doi Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity
    F Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Genes Brain Behav 9:365-71. 2010
    ..These results support the interest for GSK3-beta as a factor affecting neuropathology in major behavioural disorders, such as schizophrenia, and thus as a possible target for treatment...
  21. doi Genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene
    Elena Marino
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Neurol Sci 31:387-91. 2010
    ..So, our group studied the possible role of the SERT as a risk factor, both for migraine and mood disorders, in a sample of 96 patients affected by both pathologies...
  22. doi Searching susceptibility loci for bipolar disorder: a sib pair study on chromosome 12
    Cristina Lorenzi
    Genetic Laboratory, S Raffaele Hospital, Vita Salute University, Milan, Italy
    Neuropsychobiology 61:10-8. 2010
    ..In particular, some genome scans evidenced the role of chromosome 12. For this reason, our group chose this chromosome for a preliminary genome scan on a sample of 137 Italian sib pairs, including at least 1 bipolar subject...
  23. doi Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism
    Francesco Benedetti
    Division of Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Affect Disord 121:68-72. 2010
    ..This finding supports the hypothesis of a major role for catecholamines in the mechanism of action of chronotherapeutics, and for rs4680 in modulating this effect...
  24. doi Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation
    Francesco Benedetti
    J Clin Psychopharmacol 28:249-51. 2008
  25. ncbi Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 158:132-40. 2008
    ....
  26. ncbi How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes
    Paola Artioli
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital Scientific Institute, Milan, Italy
    Eur Neuropsychopharmacol 17:587-94. 2007
    ..These preliminary results could shed further light on the involvement of circadian genes in various aspects of physiological and psychopathological mechanisms of the brain...
  27. ncbi Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression
    Raffaella Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, Milan 20127, Italy
    Eur Neuropsychopharmacol 17:651-7. 2007
    ..Our sample has not the power to control for the possible influence of different medications on these results...
  28. ncbi Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients
    F Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Genes Brain Behav 7:20-5. 2008
    ..Our results support the hypothesis that individual clock genotype may influence several variables linked with human behaviors in normal and psychopathological conditions...
  29. ncbi Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:631-5. 2007
    ..Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders...
  30. ncbi Serotonin transporter gene influences the time course of improvement of "core" depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 149:185-93. 2007
    ....
  31. ncbi Catechol-O-methyltransferase gene variants in mood disorders in the Italian population
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy
    Psychiatr Genet 16:181-2. 2006
    ....
  32. ncbi Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness
    Enrico Lattuada
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute, Vita Salute University School of Medicine, via Stamira d Ancona n 20, 20127 Milan, Italy
    Neurosci Lett 367:152-5. 2004
    ..0002, respectively). We conclude that an interaction between clozapine and the CLOCK gene polymorphism 3111 T/C substitution could explain persistent daytime sleepiness in a significant proportion of patients treated with clozapine...
  33. ncbi Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:504-11. 2004
    ..The present study investigated possible genetic association between some polymorphisms possibly involved in antidepressant response and the occurrence of manic or hypo-manic switches during antidepressant treatment...
  34. ncbi Serotonin transporter gene (5-HTTLPR) and major psychoses
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Mol Psychiatry 7:95-9. 2002
    ..Consideration of possible stratification factors such as sex and age of onset did not significantly influence results. 5-HTTLPR variants are not therefore a liability factor for major psychoses or for major psychoses symptomatology...
  35. ncbi No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors
    A Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 104:195-203. 2001
    ..The investigated DRD2 and DRD4 gene variants therefore do not seem to play a major role in the antidepressant activity of SSRIs, at least in the present sample...
  36. ncbi Tryptophan hydroxylase gene associated with paroxetine antidepressant activity
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Stamira D Ancona 20 20127 Milan, Italy
    Eur Neuropsychopharmacol 11:375-80. 2001
    ..TPH gene variants are therefore a possible modulator of paroxetine antidepressant activity...
  37. ncbi Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders
    C Cusin
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Via Stamira d Ancona 20, 20127 Milano, Italy
    J Psychiatr Res 35:217-23. 2001
    ..018) and remitting mood disorders (P=0.006). TPH frequencies did not differ between mood disorders subtypes. Our results suggest that 5-HTTLPR variants may confer a susceptibility toward rapid cycling mood disorders...
  38. ncbi Tryptophan hydroxylase gene and major psychoses
    A Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Psychiatry Res 103:79-86. 2001
    ..TPH*A containing variants may be a protective factor for depressive symptoms among male subjects with mood disorders or for a subtype of mood disorders characterized by a mainly manic form of symptomatology...
  39. ncbi Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Milan, Italy
    Am J Med Genet 96:161-6. 2000
    ..Genetic variation at the 5HT1A and 5HT2C receptor genes does not, therefore, play a major role in the pathogenesis of mood disorders symptomatology. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:161-166, 2000...
  40. ncbi Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Mol Psychiatry 5:270-4. 2000
    ..Our results do not show that coding variants of the DRD2 S311C play a major role in conferring susceptibility to major psychoses, but they may be connected with disorganized and delusional symptomatology independently from diagnoses...
  41. ncbi Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    J Psychiatr Res 34:89-98. 2000
    ..No 5-HT1A gene variant was identified. 5-HT2A and 2C variants are not, therefore, associated with lithium prophylactic efficacy in mood disorders...
  42. ncbi Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Milano, Italy
    Psychiatry Res 89:107-14. 1999
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. DRD4 exon 3 variants are not a main factor influencing TSD outcome in bipolar disorder...
  43. ncbi Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Psychiatry Res 87:7-19. 1999
    ..DRD2, DRD4 and GABRA1 variants therefore do not appear to be associated with the outcome of lithium prophylaxis in mood disorders...
  44. ncbi Tryptophan hydroxylase gene and response to lithium prophylaxis in mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    J Psychiatr Res 33:371-7. 1999
    ..TPH variants may be a possible factor influencing the prophylactic efficacy of lithium in mood disorders...
  45. ncbi No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico H San Raffaele, University of Milan School of Medicine, Italy
    Am J Med Genet 88:481-5. 1999
    ..No interaction was observed on the other symptom factors. The serotonin transporter gene does not, therefore, interact with DRD4 in determining the symptomatology of major psychoses...
  46. ncbi Dopamine D3 receptor gene not associated with symptomatology of major psychoses
    A Serretti
    Department of Neuropsychiatric Sciences, Instituto Scientifico H San Raffaele, University of Milan School of Medicine, Italy
    Am J Med Genet 88:476-80. 1999
    ..DRD3 variants were not associated with these symptomatologic factors, and consideration of possible stratification effects, such as sex and psychiatric diagnosis, did not reveal any association either...
  47. ncbi No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders
    A Serretti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
    Psychiatry Res 86:203-9. 1999
    ..Genetic variation at the 5-HT2A receptor gene does not, therefore, appear to play a major role in the pathogenesis of major mood disorders...
  48. ncbi Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet 114:361-9. 2002
    ..Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in mood disorders...
  49. ncbi Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet 114:370-9. 2002
    ..The pathways influenced by those variants are not therefore involved with long-term lithium outcome in our sample...
  50. ncbi Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders
    A Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milano, Italy
    Pharmacogenomics J 4:267-73. 2004
    ..Further studies on independent and large samples are required to determine the reliability and direction of the possible association between SERTPR variants and lithium outcome...
  51. ncbi New antipsychotics and schizophrenia: a review on efficacy and side effects
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Curr Med Chem 11:343-58. 2004
    ....
  52. ncbi Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study
    Julien Mendlewicz
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, Belgium
    Eur J Hum Genet 12:377-82. 2004
    ..Our negative findings are not attributable to the lack of statistical power, and may contribute to clarify the role of 5-HTTLPR polymorphism in AD...
  53. ncbi A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy
    Neurosci Lett 355:37-40. 2004
    ....
  54. ncbi Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, University of Vita Salute San Raffaele, School of Medicine, Milano, Italy
    Am J Med Genet B Neuropsychiatr Genet 123:23-6. 2003
    ..Given the post-hoc nature of the finding, replication in independent samples is necessary to confirm it...
  55. ncbi Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita Salute San Raffaele, Milano, Italy
    Biol Psychiatry 54:687-92. 2003
    ..The short-term relapse that follows acute response to TSD has been successfully prevented by combining TSD with light therapy. The mechanism of action of this combined treatment is unknown...
  56. ncbi Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 121:35-8. 2003
    ..Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP...
  57. ncbi Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms
    Jayanti Chotai
    Division of Psychiatry, Department of Clinical Sciences, University of Umea, 901 85, Umea, Sweden
    Psychiatry Res 119:99-111. 2003
    ....
  58. ncbi Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Universita Vita Salute San Raffaele, School of Medicine, Milan, Italy
    Psychiatry Res 118:241-7. 2003
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. The tested gene variants are not a main factor influencing TSD outcome in bipolar disorder...
  59. ncbi Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Psychiatr Genet 13:121-6. 2003
    ..The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach...
  60. ncbi SSRIs antidepressant activity is influenced by G beta 3 variants
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Eur Neuropsychopharmacol 13:117-22. 2003
    ..009) and this effect was independent from analyzed demographic and clinical variables. These results confirm preliminary reports and shed further light on the genetics of the response to antidepressant treatments...
  61. ncbi Human nuclear transcription factor gene CREM: genomic organization, mutation screening, and association analysis in panic disorder
    K Domschke
    Department of Psychiatry, University of Munster, Munster, Germany
    Am J Med Genet B Neuropsychiatr Genet 117:70-8. 2003
    ..Functional analysis of the observed CREM P 2 promoter polymorphism as well as studies in independent panic disorder samples are necessary...
  62. ncbi No occurrence of the glutamate transporter EAAT2 A206G polymorphism in schizophrenic subjects
    M Catalano
    Mol Psychiatry 7:671-2. 2002
  63. ncbi Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders
    Cristina Cusin
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet 114:380-90. 2002
    ..Our results suggest that MAO-A, COMT, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in mood disorders...
  64. doi Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings
    Cristina Lorenzi
    Clinical Neurosciences Department, San Raffaele Turro Hospital, Vita Salute San Raffaele University, Via Stamira d Ancona 20, Milan, Italy
    Neurol Sci 31:741-9. 2010
    ..Our study confirms the role of 5-HTTLPR as a potential susceptibility factor for sporadic dementia in the Italian population, and suggests a possible interaction between 5-HTTLPR and Q7R polymorphisms in neurodegenerative diseases...