Lucia Lopalco

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection
    L Diomede
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Virol 86:4129-38. 2012
  2. ncbi request reprint Anti-cell antibodies in exposed seronegative individuals with HIV type 1-neutralizing activity
    L Lopalco
    DIBIT and Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy
    AIDS Res Hum Retroviruses 16:109-15. 2000
  3. ncbi request reprint Predictive value of anti-cell and anti-human immunodeficiency virus (HIV) humoral responses in HIV-1-exposed seronegative cohorts of European and Asian origin
    L Lopalco
    Department of Immunology and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Gen Virol 86:339-48. 2005
  4. ncbi request reprint HIV-1 and the self-nonself connection: how to sleep with the enemy and be much better off
    Lucia Lopalco
    Department of Immunology, Infectious Diseases and Transplants, San Raffaele Scientific Institute, Milan, Italy
    AIDS Rev 10:162-71. 2008
  5. pmc Natural anti-CCR5 antibodies in HIV-infection and -exposure
    Lucia Lopalco
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Transl Med 9:S4. 2011
  6. pmc CCR5: From Natural Resistance to a New Anti-HIV Strategy
    Lucia Lopalco
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, via Stamira D Ancona, 20, 20127 Milan, Italy E Mail Tel 39 02 2643 7936
    Viruses 2:574-600. 2010
  7. ncbi request reprint CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitro
    L Lopalco
    Department of Biological and Technological Research and Infectious Diseases Clinic, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 164:3426-33. 2000
  8. pmc Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens
    Claudia Pastori
    Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy
    J Virol 82:4125-34. 2008
  9. pmc Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4
    Samuele E Burastero
    Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 6:e22081. 2011
  10. ncbi request reprint Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41
    Mario Clerici
    Immunology, DISP LITA Vialba, University of Milan, Milan, Italy
    AIDS 16:1731-41. 2002

Collaborators

Detail Information

Publications32

  1. pmc Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection
    L Diomede
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Virol 86:4129-38. 2012
    ..Our findings highlight important epitopes in gp41 that appear to be associated with exposure without infection and would be important to consider for vaccine design...
  2. ncbi request reprint Anti-cell antibodies in exposed seronegative individuals with HIV type 1-neutralizing activity
    L Lopalco
    DIBIT and Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy
    AIDS Res Hum Retroviruses 16:109-15. 2000
    ....
  3. ncbi request reprint Predictive value of anti-cell and anti-human immunodeficiency virus (HIV) humoral responses in HIV-1-exposed seronegative cohorts of European and Asian origin
    L Lopalco
    Department of Immunology and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Gen Virol 86:339-48. 2005
    ..In conclusion, exposed seronegative individuals of ethnically different origins display similar signs of HIV-dependent unconventional immunity. A specific relevance must be attributed to different innate and acquired factors...
  4. ncbi request reprint HIV-1 and the self-nonself connection: how to sleep with the enemy and be much better off
    Lucia Lopalco
    Department of Immunology, Infectious Diseases and Transplants, San Raffaele Scientific Institute, Milan, Italy
    AIDS Rev 10:162-71. 2008
    ..The possible implications of these mechanisms in the design of unconventional therapies aimed to counteract the peculiar HIV-1 capability to circumvent the immune system will be discussed...
  5. pmc Natural anti-CCR5 antibodies in HIV-infection and -exposure
    Lucia Lopalco
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Transl Med 9:S4. 2011
    ..Their biological properties and their uncommon generation in subsets of HIV-infected and HIV-exposed individuals (so called ESN) will be introduced and discussed, with the aim at exploiting their potential in therapy and prevention...
  6. pmc CCR5: From Natural Resistance to a New Anti-HIV Strategy
    Lucia Lopalco
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, via Stamira D Ancona, 20, 20127 Milan, Italy E Mail Tel 39 02 2643 7936
    Viruses 2:574-600. 2010
    ..Such natural immunity has prompted strategies aimed at achieving anti-HIV humoral responses through CCR5 targeting, which will be described here...
  7. ncbi request reprint CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitro
    L Lopalco
    Department of Biological and Technological Research and Infectious Diseases Clinic, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 164:3426-33. 2000
    ..These results contribute to clarifying the phenomenon of immunologic resistance to HIV and may have implications for the development of a protective vaccine...
  8. pmc Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens
    Claudia Pastori
    Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy
    J Virol 82:4125-34. 2008
    ..These findings may be relevant to the induction of strong and efficient HIV-blocking antibodies...
  9. pmc Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4
    Samuele E Burastero
    Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 6:e22081. 2011
    ..Due to its broad-spectrum anti-HIV-1 activity and lack of immunosuppressive effects, a humanized derivative of MAb DB81 could provide a useful complement to current preventive or therapeutic strategies against HIV-1...
  10. ncbi request reprint Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41
    Mario Clerici
    Immunology, DISP LITA Vialba, University of Milan, Milan, Italy
    AIDS 16:1731-41. 2002
    ..HIV-specific IgA is present in HIV-exposed uninfected individuals (EU) and neutralizes primary strains of HIV-1 in vitro...
  11. pmc Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection
    Samuele E Burastero
    Unit of Clinical and Molecular Allergy, Division of Immunology, Infectious Diseases and Transplants, San Raffaele Scientific Institute, Milan, 20132, Italy
    J Transl Med 7:101. 2009
    ..The experimentum naturae of naturally resistant individuals indicates a strategy to design innovative strategies to neutralize HIV-1 by acting on the sharp edge between harmful and protective self-reactivity...
  12. ncbi request reprint Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals
    Mara Biasin
    Department of Immunology, Dipartimento di Scienze Precliniche Laboratorio Interdisciplinare Tecnologie Avanzate Vialba, Milano University Medical School, Milano, Italy
    J Infect Dis 195:960-4. 2007
    ..Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection...
  13. ncbi request reprint Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men
    Sergio Lo Caputo
    Unita Operativa Malattie Infettive, Ospedale SM Annunziata, Firenze, Milano, Italy
    AIDS 17:531-9. 2003
    ..Mucosal and systemic immune correlates of this condition have been analysed in HIV-1-exposed women but no data are available concerning mucosal immunity and HIV-1-specific immune responses in exposed but uninfected men...
  14. pmc Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression
    Claudia Pastori
    Infectious Diseases Clinic, San Raffaele Scientific Institute, 20127 Milan, Italy
    Blood 107:4825-33. 2006
    ..Induction of anti-CCR5 Abs could be relevant to vaccine design and therapeutics...
  15. pmc A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients
    Chiara Brombin
    Centro Universitario di Statistica per le Scienze Biomediche, University Centre of Statistics in the Biomedical Sciences, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 8:e58768. 2013
    ..Virus neutralization of primary virus strains and antibodies to gp41 were required to classify patients, suggesting that clinical profiles strongly rely on functional activity against HIV...
  16. pmc Setting of methods for analysis of mucosal antibodies in seminal and vaginal fluids of HIV seropositive subjects from Cambodian and Italian cohorts
    Carla Donadoni
    Division of Immunology, Infectious Diseases and Trasplantation, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 5:e9920. 2010
    ..High variability of published observations concerning IgA isolation and quantification underlies the strong requirement of specific methods able to maximize investigation on HIV-specific IgA...
  17. ncbi request reprint Is autoimmunity a component of natural immunity to HIV?
    Silvia Russo
    Research Consultant, San Raffaele Scientific Institute, Milano, Italy
    Curr HIV Res 4:177-90. 2006
    ..This paper will present the current knowledge on auto-antibodies observed in HIV infection, their putative mechanisms of generation and their possible implications for immune therapy...
  18. ncbi request reprint Humoral immunity in HIV-1 exposure: cause or effect of HIV resistance?
    Lucia Lopalco
    Clinics for Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Curr HIV Res 2:127-39. 2004
    ....
  19. ncbi request reprint Non-cytotoxic inhibition of HIV-1 infection by unstimulated CD8+ T lymphocytes from HIV-exposed-uninfected individuals
    Lucinda Furci
    Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Via Olgettina n 58, Milan 20132, Italy
    AIDS 16:1003-8. 2002
    ..We investigated the ability of unstimulated CD8+ T lymphocytes from EU individuals to inhibit HIV-1 infection...
  20. doi request reprint Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1
    Fabio Bignami
    Department of Clinical Sciences, University of Milano, Milano, Italy
    Blood 119:6259-67. 2012
    ..The comparison of normalized Dicer and Drosha expression in ex vivo and in vitro condition revealed that these enzymes did not affect the change of miRNA profiles, supporting the existence of a Dicer-independent biogenesis pathway...
  21. ncbi request reprint HIV-specific antibodies but not t-cell responses are associated with protection in seronegative partners of HIV-1-infected individuals in Cambodia
    Marie Nguyen
    Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    J Acquir Immune Defic Syndr 42:412-9. 2006
    ..Whereas T-cell specific immunity was not associated to protection, our results suggest that HIV-specific humoral immunity and reduced cell susceptibility to infection may contribute to protection against HIV-1 infection in Cambodian EUs...
  22. ncbi request reprint Cross-clade HIV-1-specific neutralizing IgA in mucosal and systemic compartments of HIV-1-exposed, persistently seronegative subjects
    Claudia Devito
    Department of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Acquir Immune Defic Syndr 30:413-20. 2002
    ..In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine...
  23. ncbi request reprint CCR5-specific mucosal IgA in saliva and genital fluids of HIV-exposed seronegative subjects
    Claudia Barassi
    Blood 104:2205-6. 2004
  24. ncbi request reprint Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activation
    Anna Suy
    Gynecology Department, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Infect Dis 196:1191-201. 2007
    ....
  25. pmc Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
    Kehmia Titanji
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Immunology 123:164-70. 2008
    ..Imbalance of NK cell subsets and up-regulated expression of CD27 and CD70 initiated early in HIV-1 infection may indicate NK cell activation and intrinsic defects initiated by HIV-1 to disarm the innate immune response to the virus...
  26. ncbi request reprint Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control
    Caroline Fluur
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    AIDS 21:1048-50. 2007
    ..001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state...
  27. ncbi request reprint Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells
    Morgane Bomsel
    Institut Cochin, INSERM, CNRS, Paris, France
    AIDS 21:13-22. 2007
    ..As a subset of ESN and LTNP produce anti-CCR5 antibodies both at systemic and mucosal level, we studied the role of anti-CCR5 antibodies in blocking HIV transfer through human epithelial cells...
  28. ncbi request reprint Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior
    Taha Hirbod
    Center for Molecular Medicine, Infectious Diseases Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Solna, Sweden
    J Acquir Immune Defic Syndr 43:137-43. 2006
    ....
  29. ncbi request reprint Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions
    Kehmia Titanji
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    AIDS 19:1947-55. 2005
    ..To investigate the effects of primary HIV-1 infection (PHI) and of two antiretroviral therapies [highly active antiretroviral therapy (HAART) or reverse transcriptase inhibitors (RTI)] on activation, differentiation and survival of B cells...
  30. ncbi request reprint A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study
    Felipe Garcia
    Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    AIDS 17:43-51. 2003
    ....
  31. ncbi request reprint Control of HIV during a structured treatment interruption in chronically infected individuals with vigorous T cell responses
    Franco Lori
    Research Institute for Genetic and Human Therapy RIGHT at IRCCS Policlinico S Matteo, Pavia, Italy
    HIV Clin Trials 3:115-24. 2002
    ..To study whether and under what circumstances HIV can be controlled in chronically infected patients...
  32. ncbi request reprint Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
    Kehmia Titanji
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    Blood 108:1580-7. 2006
    ..This may have important consequences for the response of HIV-infected patients to immunizations...