Research Topics
| Lucia LopalcoSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protectionL Diomede
Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
J Virol 86:4129-38. 2012..Our findings highlight important epitopes in gp41 that appear to be associated with exposure without infection and would be important to consider for vaccine design...- CCR5: From Natural Resistance to a New Anti-HIV StrategyLucia Lopalco
Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, via Stamira D Ancona, 20, 20127 Milan, Italy E Mail Tel 39 02 2643 7936
Viruses 2:574-600. 2010..Such natural immunity has prompted strategies aimed at achieving anti-HIV humoral responses through CCR5 targeting, which will be described here... - Natural anti-CCR5 antibodies in HIV-infection and -exposureLucia Lopalco
Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
J Transl Med 9:S4. 2011..Their biological properties and their uncommon generation in subsets of HIV-infected and HIV-exposed individuals (so called ESN) will be introduced and discussed, with the aim at exploiting their potential in therapy and prevention... 
HIV-1 and the self-nonself connection: how to sleep with the enemy and be much better offLucia Lopalco
Department of Immunology, Infectious Diseases and Transplants, San Raffaele Scientific Institute, Milan, Italy
AIDS Rev 10:162-71. 2008..The possible implications of these mechanisms in the design of unconventional therapies aimed to counteract the peculiar HIV-1 capability to circumvent the immune system will be discussed...- Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickensClaudia Pastori
Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy
J Virol 82:4125-34. 2008..These findings may be relevant to the induction of strong and efficient HIV-blocking antibodies... - Anti-cell antibodies in exposed seronegative individuals with HIV type 1-neutralizing activityL Lopalco
DIBIT and Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy
AIDS Res Hum Retroviruses 16:109-15. 2000.... - Predictive value of anti-cell and anti-human immunodeficiency virus (HIV) humoral responses in HIV-1-exposed seronegative cohorts of European and Asian originL Lopalco
Department of Immunology and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
J Gen Virol 86:339-48. 2005..In conclusion, exposed seronegative individuals of ethnically different origins display similar signs of HIV-dependent unconventional immunity. A specific relevance must be attributed to different innate and acquired factors... - CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitroL Lopalco
Department of Biological and Technological Research and Infectious Diseases Clinic, San Raffaele Scientific Institute, Milano, Italy
J Immunol 164:3426-33. 2000..These results contribute to clarifying the phenomenon of immunologic resistance to HIV and may have implications for the development of a protective vaccine... - Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4Samuele E Burastero
Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
PLoS ONE 6:e22081. 2011..Due to its broad-spectrum anti-HIV-1 activity and lack of immunosuppressive effects, a humanized derivative of MAb DB81 could provide a useful complement to current preventive or therapeutic strategies against HIV-1... - Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41Mario Clerici
Immunology, DISP LITA Vialba, University of Milan, Milan, Italy
AIDS 16:1731-41. 2002..CONCLUSION: These results have important implications for the development of vaccines and therapeutical strategies against HIV infection... - Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infectionSamuele E Burastero
Unit of Clinical and Molecular Allergy, Division of Immunology, Infectious Diseases and Transplants, San Raffaele Scientific Institute, Milan, 20132, Italy
J Transl Med 7:101. 2009..The experimentum naturae of naturally resistant individuals indicates a strategy to design innovative strategies to neutralize HIV-1 by acting on the sharp edge between harmful and protective self-reactivity... - Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual menSergio Lo Caputo
, Ospedale SM Annunziata, Firenze, Milano, Italy
AIDS 17:531-9. 2003..CONCLUSIONS: This is the first report of HIV-specific mucosal immunity in ESN men. These data add to the body of knowledge of the immune correlates present in exposed, uninfected individuals and might be important in vaccine design... - Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progressionClaudia Pastori
Infectious Diseases Clinic, San Raffaele Scientific Institute, 20127 Milan, Italy
Blood 107:4825-33. 2006..Induction of anti-CCR5 Abs could be relevant to vaccine design and therapeutics... - Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individualsMara Biasin
Department of Immunology, Dipartimento di Scienze Precliniche Laboratorio Interdisciplinare Tecnologie Avanzate Vialba, Milano University Medical School, Milano, Italy
J Infect Dis 195:960-4. 2007..Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection... - Setting of methods for analysis of mucosal antibodies in seminal and vaginal fluids of HIV seropositive subjects from Cambodian and Italian cohortsCarla Donadoni
Division of Immunology, Infectious Diseases and Trasplantation, San Raffaele Scientific Institute, Milan, Italy
PLoS ONE 5:e9920. 2010..High variability of published observations concerning IgA isolation and quantification underlies the strong requirement of specific methods able to maximize investigation on HIV-specific IgA... - Is autoimmunity a component of natural immunity to HIV?Silvia Russo
Research Consultant, San Raffaele Scientific Institute, Milano, Italy
Curr HIV Res 4:177-90. 2006..This paper will present the current knowledge on auto-antibodies observed in HIV infection, their putative mechanisms of generation and their possible implications for immune therapy... - Humoral immunity in HIV-1 exposure: cause or effect of HIV resistance?Lucia Lopalco
Clinics for Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
Curr HIV Res 2:127-39. 2004.... - Non-cytotoxic inhibition of HIV-1 infection by unstimulated CD8+ T lymphocytes from HIV-exposed-uninfected individualsLucinda Furci
Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Via Olgettina n 58, Milan 20132, Italy
AIDS 16:1003-8. 2002..We investigated the ability of unstimulated CD8+ T lymphocytes from EU individuals to inhibit HIV-1 infection... 
Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1Fabio Bignami
Department of Clinical Sciences, University of Milano, Milano, Italy
Blood 119:6259-67. 2012..The comparison of normalized Dicer and Drosha expression in ex vivo and in vitro condition revealed that these enzymes did not affect the change of miRNA profiles, supporting the existence of a Dicer-independent biogenesis pathway...- Cross-clade HIV-1-specific neutralizing IgA in mucosal and systemic compartments of HIV-1-exposed, persistently seronegative subjectsClaudia Devito
Department of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
J Acquir Immune Defic Syndr 30:413-20. 2002..In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine... - Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activationAnna Suy
Gynecology Department, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Infect Dis 196:1191-201. 2007.... - Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infectionKehmia Titanji
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Immunology 123:164-70. 2008..Imbalance of NK cell subsets and up-regulated expression of CD27 and CD70 initiated early in HIV-1 infection may indicate NK cell activation and intrinsic defects initiated by HIV-1 to disarm the innate immune response to the virus... - CCR5-specific mucosal IgA in saliva and genital fluids of HIV-exposed seronegative subjectsClaudia Barassi
Blood 104:2205-6. 2004 - HIV-specific antibodies but not t-cell responses are associated with protection in seronegative partners of HIV-1-infected individuals in CambodiaMarie Nguyen
Institut Pasteur du Cambodge, Phnom Penh, Cambodia
J Acquir Immune Defic Syndr 42:412-9. 2006..Whereas T-cell specific immunity was not associated to protection, our results suggest that HIV-specific humoral immunity and reduced cell susceptibility to infection may contribute to protection against HIV-1 infection in Cambodian EUs... - Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behaviorTaha Hirbod
Center for Molecular Medicine, Infectious Diseases Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Solna, Sweden
J Acquir Immune Defic Syndr 43:137-43. 2006..CONCLUSIONS: Induction of IFNalpha and RANTES expression in cervical mucosa may contribute to protection of sexual HIV-1 transmission in subjects with a higher risk behavior... - Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cellsMorgane Bomsel
Institut Cochin, INSERM, CNRS, Paris, France
AIDS 21:13-22. 2007..As a subset of ESN and LTNP produce anti-CCR5 antibodies both at systemic and mucosal level, we studied the role of anti-CCR5 antibodies in blocking HIV transfer through human epithelial cells... - Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune controlCaroline Fluur
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
AIDS 21:1048-50. 2007..001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state... - Control of HIV during a structured treatment interruption in chronically infected individuals with vigorous T cell responsesFranco Lori
Research Institute for Genetic and Human Therapy RIGHT at IRCCS Policlinico S Matteo, Pavia, Italy
HIV Clin Trials 3:115-24. 2002..To study whether and under what circumstances HIV can be controlled in chronically infected patients... - Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctionsKehmia Titanji
Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
AIDS 19:1947-55. 2005..CONCLUSION: B cell dysfunctions found in chronic HIV-1 infection appear during PHI and initiation of antiretroviral therapy early during infection may help to preserve the B cell compartment... - A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized studyFelipe Garcia
Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
AIDS 17:43-51. 2003.... - Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infectionKehmia Titanji
Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
Blood 108:1580-7. 2006..This may have important consequences for the response of HIV-infected patients to immunizations...