Paolo Lissoni

Summary

Affiliation: San Gerardo Hospital
Country: Italy

Publications

  1. ncbi Efficacy of cancer chemotherapy in relation to the pretreatment number of lymphocytes in patients with metastatic solid tumors
    P Lissoni
    Division of Radiation Oncology Clinical Surgery III, S. Gerardo Hospital, Monza, Milan, Italy
    Int J Biol Markers 19:135-40. 2004
  2. ncbi Effects of the conventional antitumor therapies surgery, chemotherapy, radiotherapy and immunotherapy on regulatory T lymphocytes in cancer patients
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale S Gerardo, 20052 Monza, Milan, Italy
    Anticancer Res 29:1847-52. 2009
  3. ncbi A reinterpretation of the pathogenesis and cure of cancer according to the psychoneuroimmunological discoveries
    Paolo Lissoni
    Institute of Biological Medicine, Milan, Italy
    Methods Mol Biol 934:183-92. 2012
  4. ncbi Immune and endocrine mechanisms of advanced cancer-related hypercortisolemia
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 21:647-50. 2007
  5. ncbi Efficacy of cancer chemotherapy in relation to synchronization of cortisol rhythm, immune status and psychospiritual profile in metastatic non-small cell lung cancer
    P Lissoni
    Divisions of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 22:257-62. 2008
  6. ncbi Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors
    Paolo Lissoni
    Division of Radiation Oncology, S Gerardo Hospital, Monza, Italy
    Anticancer Res 28:1377-81. 2008
  7. ncbi A study of immunoendocrine strategies with pineal indoles and interleukin-2 to prevent radiotherapy-induced lymphocytopenia in cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 22:397-400. 2008
  8. ncbi Brain irradiation-induced lymphocytosis predicts response in cancer patients with brain metastases
    P Lissoni
    Division of Radiotherapy and Oncology, San Gerardo Hospital, Monza Milan Italy
    Int J Biol Markers 23:111-4. 2008
  9. ncbi A spiritual approach in the treatment of cancer: relation between faith score and response to chemotherapy in advanced non-small cell lung cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 22:577-81. 2008
  10. ncbi Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milan, Italy
    J Pineal Res 35:12-5. 2003

Collaborators

Detail Information

Publications83

  1. ncbi Efficacy of cancer chemotherapy in relation to the pretreatment number of lymphocytes in patients with metastatic solid tumors
    P Lissoni
    Division of Radiation Oncology Clinical Surgery III, S. Gerardo Hospital, Monza, Milan, Italy
    Int J Biol Markers 19:135-40. 2004
    ..Pretreatment lymphocyte count may represent a new, simple biological marker to be taken into consideration by oncologists in the chemotherapeutic treatment of metastatic cancer...
  2. ncbi Effects of the conventional antitumor therapies surgery, chemotherapy, radiotherapy and immunotherapy on regulatory T lymphocytes in cancer patients
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale S Gerardo, 20052 Monza, Milan, Italy
    Anticancer Res 29:1847-52. 2009
    ..This study evaluated the influence of the four main conventional anticancer therapies (surgery, chemotherapy, radiotherapy, immunotherapy) on the CD4/CD4CD25 ratio...
  3. ncbi A reinterpretation of the pathogenesis and cure of cancer according to the psychoneuroimmunological discoveries
    Paolo Lissoni
    Institute of Biological Medicine, Milan, Italy
    Methods Mol Biol 934:183-92. 2012
    ....
  4. ncbi Immune and endocrine mechanisms of advanced cancer-related hypercortisolemia
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 21:647-50. 2007
    ....
  5. ncbi Efficacy of cancer chemotherapy in relation to synchronization of cortisol rhythm, immune status and psychospiritual profile in metastatic non-small cell lung cancer
    P Lissoni
    Divisions of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 22:257-62. 2008
    ....
  6. ncbi Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors
    Paolo Lissoni
    Division of Radiation Oncology, S Gerardo Hospital, Monza, Italy
    Anticancer Res 28:1377-81. 2008
    ....
  7. ncbi A study of immunoendocrine strategies with pineal indoles and interleukin-2 to prevent radiotherapy-induced lymphocytopenia in cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 22:397-400. 2008
    ....
  8. ncbi Brain irradiation-induced lymphocytosis predicts response in cancer patients with brain metastases
    P Lissoni
    Division of Radiotherapy and Oncology, San Gerardo Hospital, Monza Milan Italy
    Int J Biol Markers 23:111-4. 2008
    ..Therefore, evidence of brain irradiation-induced lymphocytosis may predict the efficacy of radiotherapy...
  9. ncbi A spiritual approach in the treatment of cancer: relation between faith score and response to chemotherapy in advanced non-small cell lung cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 22:577-81. 2008
    ....
  10. ncbi Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milan, Italy
    J Pineal Res 35:12-5. 2003
    ..This suggests a new biochemotherapeutic strategy in the treatment of human neoplasms...
  11. ncbi A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer
    Paolo Lissoni
    Division of Radiation Oncology, St Gerardo Hospital, Monza, Milan, Italy
    In Vivo 23:171-5. 2009
    ..The antiproliferative action is determined by anthracenic and antraquinonic molecules, while the immunostimulating activity is mainly due to acemannan...
  12. ncbi HER2 expression in breast cancer: correlation with endocrine function and psychological status in operable and metastatic breast cancer
    Paolo Lissoni
    Institue of Biological Medicine, Milan, Italy
    In Vivo 23:987-9. 2009
    ..In this study, we evaluated the relation between HER2 expression and PRL blood concentrations in women with metastatic breast cancer women and those whit operable breast cancer patients prior to before and 7 days after surgery...
  13. ncbi Principles of psychoneuroendocrinoimmunotherapy of cancer
    Paolo Lissoni
    Ambrosian University of Milan, Italy
    Immunotherapy 4:77-86. 2012
    ....
  14. ncbi Psychoneuroendocrine modulation of regulatory T lymphocyte system: in vivo and in vitro effects of the pineal immunomodulating hormone melatonin
    Luigi Vigoré
    Laboratory of Immunomicrobiology, S Gerardo Hospital, Monza, Milan, Italy
    In Vivo 24:787-9. 2010
    ..This study was performed to investigate the in vivo and in vitro effects of MLT on T-reg generation...
  15. ncbi Synchronization of cortisol circadian rhythm by the pineal hormone melatonin in untreatable metastatic solid tumor patients and its possible prognostic significance on tumor progression
    Fernando Brivio
    Surgical Division, Bassini Hospital, Cinisello Balsamo, Milan, Italy
    In Vivo 24:239-41. 2010
    ..On this basis, a study was planned to evaluate the effects of a chronic treatment with the pineal hormone melatonin (MLT) in advanced cancer patients with altered cortisol circadian rhythm...
  16. ncbi Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study
    Paolo Lissoni
    Division of Radiation Oncology, S. Gerardo Hospital, Monza (Milan, Italy
    Neuro Endocrinol Lett 24:259-62. 2003
    ..Since Cartesius was the first author who suggested the fundamental role of the pineal in the connection between consciousness and biological life, this therapy could be defined as a Cartesian therapy...
  17. ncbi Psychooncology and cancer progression-related alterations of pleasure-associated neurochemical system: Abnormal neuroendocrine response to apomorphine in advanced cancer patients
    Paolo Lissoni
    Division of Radiation Oncology, St Gerardo Hospital, 20052 Monza, Milan, Italy
    Neuro Endocrinol Lett 24:50-3. 2003
    ....
  18. ncbi Neuroimmunotherapy of untreatable metastatic solid tumors with subcutaneous low-dose interleukin-2, melatonin and naltrexone: modulation of interleukin-2-induced antitumor immunity by blocking the opioid system
    Paolo Lissoni
    Division of Radiation Oncology, S. Gerardo Hospital, 20052 Monza (Milan, Italy
    Neuro Endocrinol Lett 23:341-4. 2002
    ....
  19. ncbi Reduction of cisplatin-induced anemia by the pineal indole 5-methoxytryptamine in metastatic lung cancer patients
    Paolo Lissoni
    Division of Radiation Oncology, S. Gerardo Hospital, 20052 Monza, Milan, Italy
    Neuro Endocrinol Lett 24:83-5. 2003
    ..Moreover, the study would suggest that 5-MTT, as well as previously demonstrated for MLT, may also enhance the cytotoxic activity of cancer chemotherapy...
  20. ncbi Endocrine effects of erythropoietin in cancer patients
    Paolo Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Milano, Italy
    Hematology 9:363-7. 2004
    ..Therefore, further studies, by evaluating the endocrine effects of a chronic treatment with EPO, will be required to establish which may be its effect on IGF-1 endogenous production, and its consequence on survival time...
  21. ncbi Pre-operative immunoprophylaxis with interleukin-2 may improve prognosis in radical surgery for colorectal cancer stage B-C
    Fernando Brivio
    University of Milano Bicocca, Department of Surgical Sciences and Intensive Care, III Division of General Surgery, Monza, Italy
    Anticancer Res 26:599-603. 2006
    ..Therefore, the early activation of the antineoplastic immune system in the first post-operative days following a presurgical activation with IL-2 may counteract the growth of minimal residual disease and prevent late disease progression...
  22. ncbi Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms
    P Lissoni
    Division of Radiation Oncology, Ospedale S Gerardo, Via Donizetti 106, 20052 Monza, Milan, Italy
    Pathol Biol (Paris) 55:201-4. 2007
    ..These results confirm in human the anticancer therapeutic properties of the pineal hormone MLT, which may enhance the efficacy of the standard anticancer chemotherapies...
  23. ncbi Enhancement of the efficacy of chemotherapy with oxaliplatin plus 5-fluorouracil by pretreatment with IL-2 subcutaneous immunotherapy in metastatic colorectal cancer patients with lymphocytopenia prior to therapy
    P Lissoni
    Division of Radiation Oncology, S. Gerardo Hospital, Monza, Milan, Italy
    In Vivo 19:1077-80. 2005
    ....
  24. ncbi Relationship between psychoncology and psychoneuroendocrinoimmunology (PNEI): enhanced T-regulatory lymphocyte activity in cancer patients with self-punishement, evaluated by Rorschach test
    Giuseppina Messina
    Psychological Service, Maggiore Policlinico Hospital, Milan, Italy
    In Vivo 24:75-8. 2010
    ....
  25. ncbi A progress study of 100 cancer patients treated by acupressure for chemotherapy-induced vomiting after failure with the pharmacological approach
    G Gardani
    Department of Radiotherapy and Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Minerva Med 98:665-8. 2007
    ..The aim of this study was to confirm these preliminary data...
  26. ncbi A psychoncological study of lymphocyte subpopulations in relation to pleasure-related neurobiochemistry and sexual and spiritual profile to Rorschach's test in early or advanced cancer patients
    G Messina
    Psychological Service, San Gerardo Hospital, Monza, Milano, Italy
    J Biol Regul Homeost Agents 17:322-6. 2003
    ....
  27. ncbi A randomized study of immunotherapy with low-dose subcutaneous interleukin-2 plus melatonin vs chemotherapy with cisplatin and etoposide as first-line therapy for advanced non-small cell lung cancer
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italia
    Tumori 80:464-7. 1994
    ....
  28. ncbi A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma
    P Lissoni
    Divisione di Radioterapia, San Gerardo Hospital, Milan, Italy
    Br J Cancer 69:196-9. 1994
    ..The treatment was well tolerated in both groups of patients. This study shows that the concomitant administration of the pineal hormone MLT may increase the efficacy of low-dose IL-2 subcutaneous therapy...
  29. ncbi The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation
    Paolo Lissoni
    Division of Radiation Oncology, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Anticancer Res 28:3743-8. 2008
    ..The present study aimed to evaluate the influence of the endogenous cannabinoid anandamide (AEA) on T-cell phenotype and function...
  30. ncbi A new neuroimmunotherapeutic strategy of subcutaneous low-dose interleukin-2 plus the long-acting opioid antagonist naltrexone in metastatic cancer patients progressing on interleukin-2 alone
    Paolo Lissoni
    Division of Radiation Oncology, S. Gerardo Hospital, Monza, Milan, Italy
    Neuro Endocrinol Lett 23:255-8. 2002
    ..CONCLUSIONS: This study shows that a blockade of the brain opioid system, which plays a physiological immunosuppressive role, may improve the anticancer effects of IL-2 in humans...
  31. ncbi Enhancement of the efficacy of cancer chemotherapy by the pineal hormone melatonin and its relation with the psychospiritual status of cancer patients
    Giuseppina Messina
    Psychological Service, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Res Med Sci 15:225-8. 2010
    ..This study was performed to evaluate the efficacy of a biochemotherapeutic regimen in metastatic cancer patients, and its therapeutic activity in relation to the psychospiritual status of patients...
  32. ncbi Effects of IL-2 preoperative immunotherapy on surgery-induced changes in angiogenic regulation and its prevention of VEGF increase and IL-12 decline
    Fernando Brivio
    3rd Division of General Surgery, Surgery Clinic of 2nd University of Milano Bicocca, San Gerardo Hospital, Monza, Milano, Italy
    Hepatogastroenterology 49:385-7. 2002
    ....
  33. ncbi A phase II study of chemoneuroimmunotherapy with platinum, subcutaneous low-dose interleukin-2 and the pineal neurohormone melatonin (P.I.M.) as a second-line therapy in metastatic melanoma patients progressing on dacarbazine plus interferon-alpha
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza, Milani, Italy
    In Vivo 16:93-6. 2002
    ....
  34. ncbi Biological and clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer
    P Lissoni
    Divisione di Radioterapia Oncologica, Hospital of Monza, Milan, Italy
    Br J Cancer 66:155-8. 1992
    ....
  35. ncbi A psychoneuroendocrine study of brain dopaminergic sensitivity in locally limited or metastatic cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza, Milano, Italy
    In Vivo 17:647-50. 2003
    ..Therefore, the psychological condition of cancer patients would not depend only on psychological factors, but it could be due at least in part to cancer-related neuroendocrine alterations involving the dopaminergic system...
  36. ncbi Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract
    P Lissoni
    Divisione di Radioterapia Oncologica, San Gerardo Hospital, Milan, Italy
    Br J Cancer 67:1404-7. 1993
    ..This study shows that the immunotherapy with low-dose IL-2 plus the pineal hormone MLT is a new well tolerated and effective therapy of advanced tumours of the digestive tract, mainly in gastric cancer and hepatocarcinoma...
  37. ncbi A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano
    Tumori 76:58-60. 1990
    ..However, the pineal hormone could be usefully employed as supportive care to improve the quality of life in these patients for whom no standard treatment is yet available...
  38. ncbi Melatonin increase as predictor for tumor objective response to chemotherapy in advanced cancer patients
    P Lissoni
    Division of Radiation Oncology, Ospedale San Gerardo, Monza, Milano, Italia
    Tumori 74:339-45. 1988
    ..Moreover, it suggests that the antineoplastic effect of cytotoxic drugs may require participation of the pineal gland...
  39. ncbi Immunotherapy with low-dose subcutaneous interleukin-2 plus beta-interferon as a second-line therapy for metastatic colorectal carcinoma
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 79:343-6. 1993
    ..Further studies in patients with less advanced disease are needed to better define the impact of the immune improvement induced by low-dose IL-2 plus beta-IFN on the clinical course of the neoplastic disease...
  40. ncbi Effect of acupressure on nausea and vomiting induced by chemotherapy in cancer patients
    G Gardani
    Department of Radiotherapy and Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Minerva Med 97:391-4. 2006
    ..The aim of this study was to evaluate the efficacy of acupressure in the treatment of chemotherapy-induced vomiting resistant to the standard antiemetic therapies...
  41. ncbi A case-control study of Panicum Miliaceum in the treatment of cancer chemotherapy-induced alopecia
    G Gardani
    Department of Radiotherapy and Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Minerva Med 98:661-4. 2007
    ..The aim of this study was to analyze the efficacy of Panicum Miliaceum in cancer patients treated with the most potent chemotherapeutic drugs in terms of hair loss, consisting of cisplatin (CDDP) and anthracyclines...
  42. ncbi Cortisol response to an acute injection of IL-2 in healthy subjects and cancer patients: a first immunoneuroendocrine standardized clinical test to explore the interactions between immune and neuroendocrine systems
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milano, Italy
    J Biol Regul Homeost Agents 19:141-4. 2005
    ....
  43. ncbi Cancer chemotherapy-induced lymphocytosis: a revolutionary discovery in the medical oncology
    P Lissoni
    Division of Radiation Oncology, Milan, Italy
    J Biol Regul Homeost Agents 20:29-35. 2006
    ....
  44. ncbi Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine as a new oncostatic pineal agent
    P Lissoni
    Division of Radiation Oncology, S Gerardo, Monza, Milan, Italy
    Pathol Biol (Paris) 55:198-200. 2007
    ....
  45. ncbi Changes in circulating VEGF levels in relation to clinical response during chemotherapy for metastatic cancer
    P Lissoni
    Division of Radiation Oncology, University of Milan-Bicocca, San Gerardo Hospital, Monza, Italy
    Int J Biol Markers 18:152-5. 2003
    ..05). These results suggest that changes in VEGF levels during chemotherapy may represent a useful biomarker to predict the effect of chemotherapy in terms of tumor response and survival in patients with metastatic solid neoplasms...
  46. ncbi A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients
    P Lissoni
    Divisione di Radioterapia Oncologica, San Gerardo Hospital, Monza, Milan, Italy
    Br J Cancer 74:1466-8. 1996
    ..This phase II study would suggest that the neuroendocrine combination with TMX plus MLT may have some benefit in untreatable metastatic solid tumour patients, either in controlling cancer cell proliferation or improving the PS...
  47. ncbi Anti-angiogenic activity of melatonin in advanced cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza, Milan, Italy
    Neuro Endocrinol Lett 22:45-7. 2001
    ....
  48. ncbi Second-line therapy with interferon-alpha plus vinblastine in metastatic renal cell cancer patients progressed under interleukin-2 subcutaneous immunotherapy
    F Paolorossi
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Milano, Italy
    Tumori 81:45-7. 1995
    ....
  49. ncbi Ten-year survival results in metastatic renal cell cancer patients treated with monoimmunotherapy with subcutaneous low-dose interleukin-2
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Anticancer Res 22:1061-4. 2002
    ....
  50. ncbi Neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin as a second-line treatment in metastatic colorectal carcinoma
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, Monza, Milano, Italy
    Tumori 78:383-7. 1992
    ....
  51. ncbi Clinical and biological effects of interleukin-2 with or without a concomitant administration of granulocyte-macrophage colony-stimulating factor in metastatic cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    In Vivo 17:73-5. 2003
    ..This preliminary study suggests that the concomitant administration of GM-CSF does not enhance the therapeutic efficacy of IL-2 immunotherapy of metastatic renal cell cancer...
  52. ncbi Alteration of opioid peptide circadian rhythm in cancer patients
    S Barni
    Division of Radiation Oncology, Ospedale San Gerardo, Monza, Milano, Italia
    Tumori 74:357-60. 1988
    ..This study shows an altered opioid activity in human neoplasms, whose clinical significance remains to be determined...
  53. ncbi Cancer as the main aging factor for humans: the fundamental role of 5-methoxy-tryptamine in reversal of cancer-induced aging processes in metabolic and immune reactions by non-melatonin pineal hormones
    Paolo Lissoni
    San Gerardo Hospital, 20052 Monza Milan, Italy
    Curr Aging Sci 5:231-5. 2012
    ..8/25 [32%], P < 0.05). Finally, the association of 5-MTT with MLT induced disease stabilization in 4 of 14 (29%) untreatable metastatic cancer patients who did not respond to MLT alone...
  54. ncbi Psychoimmunological analysis of cancer patients: correlation with the prognosis
    Giuseppina Messina
    Fondazione Ca Granda Maggiore Hospital Policlinico, University of Milan, Milan, Italy
    Curr Aging Sci 5:263-72. 2012
    ..These preliminary psychological studies seem to suggest that a pre-treatment analysis of psychological and spiritual status may predict the efficacy of both chemotherapy and immunotherapy in advanced cancer patients...
  55. ncbi Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorour
    G Cerea
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza, Milan, Italy
    Anticancer Res 23:1951-4. 2003
    ..Moreover, since the dose reduction of CPT-11 does not influence its efficacy, the dose of CPT-11 for successive studies might be not greater than 70 mg/m2...
  56. ncbi Prevention by L-carnitine of interleukin-2 related cardiac toxicity during cancer immunotherapy
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Tumori 79:202-4. 1993
    ..Since cardiac metabolism depends mainly on fatty acid oxidation, the stimulatory role of L-carnitine on fatty acid oxidation could explain at least in part its ability to prevent heart disturbances in response to IL-2 administration...
  57. ncbi Lymphocytosis decline is not responsible for tumor progression in cancer patients chronically treated with interleukin-2
    P Lissoni
    Divisione di Radioterapia Oncologia, Ospedale S. Gerardo, Monza, Italy
    Tumori 80:283-5. 1994
    ..Further studies, carried out to analyze the functional status of immune cells at the time of tumor progression, will be necessary to define the role of immunity in cancer patients progressing under IL-2 chronic therapy...
  58. ncbi Efficacy of HT 7 point acupressure stimulation in the treatment of insomnia in cancer patients and in patients suffering from disorders other than cancer
    R Cerrone
    Department of Radiotherapy and Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Minerva Med 99:535-7. 2008
    ..Recently, however, both melatonin and acupressure have appear to be active in sleep disorders. The aim of study was to evaluate the efficacy of HT 7 point acupressure in insomnia...
  59. ncbi Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone
    P Lissoni
    Divisione di Radioterapia Oncologica, San Gerardo Hospital, Monza, Milan, Italy
    Br J Cancer 71:854-6. 1995
    ..This pilot phase II study would suggest that the concomitant administration of the pineal hormone MLT may induce objective tumour regressions in metastatic breast cancer patients refractory to TMX alone...
  60. ncbi A radiologic study by CT scan of pineal size in cancer patients: correlation to melatonin blood levels
    M Tagliabue
    Servizio di Radiodiagnostica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 75:226-8. 1989
    ..Finally, cancer patients did not show a higher degree of pineal calcifications than controls. The clinical significance of pineal enlargement in cancer patients remains to be understood...
  61. ncbi Neuroendocrine effects of subcutaneous interleukin-2 injection in cancer patients
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 77:212-5. 1991
    ..These results suggest that the endocrine effects of subcutaneous IL-2 therapy are similar to those previously described with intravenous administration...
  62. ncbi A clinical study of taxotere versus taxotere plus the antiprolactinemic agent bromocriptine in metastatic breast cancer pretreated with anthracyclines
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Anticancer Res 22:1131-4. 2002
    ..025). This preliminary clinical study would suggest that the inhibition of PRL secretion by antiprolactinemic drugs such as bromocriptine may enhance the efficacy of chemotherapy for metastatic breast cancer...
  63. ncbi Antiprolactinemic approach in the treatment of metastatic breast cancer: a phase II study of polyneuroendocrine therapy with LHRH-analogue, tamoxifen and the long-acting antiprolactinemic drug cabergoline
    P Lissoni
    Division of Radiation, Oncology, San Gerardo Hospital, 20052 Monza, Milan, Italy
    Anticancer Res 23:733-6. 2003
    ....
  64. ncbi Efficacy of IL-2 immunotherapy in metastatic renal cell carcinoma in relation to the psychic profile as evaluated using the Rorschach test
    G Messina
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza, Milan, Italy
    Anticancer Res 27:2985-8. 2007
    ..On this basis, a study was planned in an attempt to evaluate relations existing between psychological status, analysed using the Rorschach test and efficacy of IL-2 immunotherapy in the treatment of metastatic renal cell cancer patients...
  65. ncbi Efficacy of monochemotherapy with docetaxel (taxotere) in relation to prolactin secretion in heavily pretreated metastatic breast cancer
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza (Milan, Italy
    Neuro Endocrinol Lett 22:27-9. 2001
    ..Therefore, a concomitant administration of anti-prolactinemic agents, such as bromocriptine, could enhance the efficacy of chemotherapy itself...
  66. ncbi Abrogation of surgery-induced IL-6 hypersecretion by presurgical immunotherapy with IL-2 and its importance in the prevention of postoperative complications
    F Brivio
    Third Surgery Division, S. Gerardo Hospital, Monza, Milan, Italy
    J Biol Regul Homeost Agents 15:370-4. 2001
    ....
  67. ncbi Evidence for altered opioid activity in patients with cancer
    P Lissoni
    Division of Radiation Oncology, Ospedale San Gerardo, Monza, Milan, Italy
    Br J Cancer 56:834-7. 1987
    ....
  68. ncbi Endocrine and clinical effects of an LHRH analogue in pretreated advanced breast cancer
    P Lissoni
    Division of Radiation Oncology, Ospedale San Gerardo, Monza, Italy
    Tumori 74:303-8. 1988
    ....
  69. ncbi Evaluation of the cardiovascular toxicity related to cancer immunotherapy with interleukin-2 by monitoring atrial natriuretic peptide secretion: a case report
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 76:603-5. 1990
    ....
  70. ncbi Mitoxantrone as a single agent in pretreated metastatic breast cancer: effects on T lymphocyte subsets and their relation to clinical response
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 77:227-31. 1991
    ..However, the DHAD-induced changes in lymphocyte subsets do not seem to be related to the clinical response in breast cancer...
  71. ncbi Enhancement of the efficacy of weekly low-dose taxotere by the long acting anti-prolactinemic drug cabergoline in pretreated metastatic breast cancer
    L Frontini
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Anticancer Res 24:4223-6. 2004
    ..It may also be recommended in heavily pretreated patients or in those with poor clinical status...
  72. ncbi A phase II study of subcutaneous low-dose interleukin-2 plus erythropoietin in metastatic renal cell carcinoma progressing on interleukin-2 alone
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Anticancer Res 21:777-9. 2001
    ....
  73. ncbi Radiotherapy-induced lymphocytopenia: changes in total lymphocyte count and in lymphocyte subpopulations under pelvic irradiation in gynecologic neoplasms
    P Lissoni
    Division of Radiation Oncology, S Gerardo Hospital, Monza, Milano, Italy
    J Biol Regul Homeost Agents 19:153-8. 2005
    ..This study confirms that pelvic RT may induce severe lymphocytopenia which could negatively influence the efficacy of RT itself...
  74. ncbi Endocrine effects of granulocyte colony-stimulating factor in cancer patients
    F Rovelli
    Laboratorio Analisi, Ospedale San Gerardo, Monza, Italy
    Tumori 81:438-9. 1995
    ..CONCLUSIONS: The study showed that G-CSF has no substantial endocrine affects in humans. Therefore, G-CSF would differ from GM-CSF not only for its hemopoietic properties, but also from an endocrine point of view...
  75. ncbi Effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women
    S Barni
    Division of Radiation Oncology, San Gerardo Hospital, Monza (MI, Italy
    Tumori 82:65-7. 1996
    ....
  76. ncbi Subcutaneous therapy with low-dose interleukin-2 plus the neurohormone melatonin in metastatic gastric cancer patients with low performance status
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza (Milano, Italy
    Tumori 79:401-4. 1993
    ....
  77. ncbi Immunoendocrine therapy with interleukin-2 (IL-2) and medroxyprogesterone acetate (MPA): a randomized study with or without MPA in metastatic renal cancer patients during IL-2 maintenance treatment after response or stable disease to IL-2 subcutaneous the
    P Lissoni
    Division of Radiation Oncology, San Gerado Hospital, Monza, Milan, Italy
    Tumori 79:246-9. 1993
    ..A longer follow-up will be required to evaluate the influence of MPA on overall survival...
  78. ncbi A randomized study of low-dose interleukin-2 subcutaneous immunotherapy versus interleukin-2 plus interferon-alpha as first line therapy for metastatic renal cell carcinoma
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, Monza (Milano, Italy
    Tumori 79:397-400. 1993
    ..CONCLUSIONS: The present results, which require confirmation in a larger series, indicate that combination with IFN does not increase the efficacy of IL-2 subcutaneous immunotherapy in metastatic RCC but only the toxicity of treatment...
  79. ncbi Free-from-progression period and overall short preoperative immunotherapy with IL-2 increases the survival of pancreatic cancer patients treated with macroscopically radical surgery
    R Caprotti
    Department of General Surgery, San Gerardo Hospital, Monza, Milan, Italy
    Anticancer Res 28:1951-4. 2008
    ..Previous studies in colorectal cancer demonstrated that surgery-induced lymphocytopenia may be abrogated by a brief preoperative administration of IL-2...
  80. ncbi Progress report on the palliative therapy of 100 patients with neoplastic effusions by intracavitary low-dose interleukin-2
    P Lissoni
    Division of Radiation Oncology, S. Gerardo Hospital, Monza, Italy
    Oncology 60:308-12. 2001
    ..Further studies are needed in order to compare the effectiveness of intracavitary IL-2 with other standard treatments...
  81. ncbi Stimulation of IL-12 secretion by GM-CSF in advanced cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, Monza, Milano, Italy
    J Biol Regul Homeost Agents 15:163-5. 2001
    ..In any case, this study would justify further research in the emerging oncological applications of GM-CSF as an immunomodulatory agent on host anticancer defenses...
  82. ncbi Correlation of serum interleukin-2 levels, soluble interleukin-2 receptors and T lymphocyte subsets in cancer patients
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 76:14-7. 1990
    ..These results would suggest that metastatic dissemination is associated with a decreased IL-2 production in vivo, and that reduced IL-2 production is more frequent in patients with low CD4/CD8 ratio...
  83. ncbi Postoperative hyperprolactinemia could predict longer disease-free and overall survival in node-negative breast cancer patients
    Mario Mandala
    Division of Medical Oncology, Treviglio Hospital, Italy
    Oncology 63:370-7. 2002
    ..Surgery-induced hyperprolactinemia may be associated with a longer disease-free survival in both patients with or without node involvement...