Research Topics
Species | Luca GianniSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Detail Information
Publications
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialLuca Gianni
Oncologia Medica, San Raffaele Cancer Centre, Milan, Italy
Lancet Oncol 13:25-32. 2012..We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and trastuzumab without chemotherapy in the neoadjuvant setting...- Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trialLuca Gianni
Department of Medical Oncology, San Raffaele Institute, Milan, Italy
Lancet Oncol 12:236-44. 2011..We aimed to assess disease-free survival and overall survival after a median follow-up of 4 years for patients enrolled on the Herceptin Adjuvant (HERA) trial... - Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HERLuca Gianni
Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Lancet 375:377-84. 2010..We aimed to assess event-free survival in patients with HER2-positive locally advanced or inflammatory breast cancer receiving neoadjuvant chemotherapy with or without 1 year of trastuzumab... - Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancerGabriella Mariani
Department of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy
Nat Clin Pract Oncol 6:93-104. 2009..Current data do not support the use of trastuzumab for more than 1 year. The analysis of 2-year treatment with trastuzumab is expected to be available in 2009... - Phase III trial evaluating the addition of paclitaxel to doxorubicin followed by cyclophosphamide, methotrexate, and fluorouracil, as adjuvant or primary systemic therapy: European Cooperative Trial in Operable Breast CancerLuca Gianni
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
J Clin Oncol 27:2474-81. 2009..To evaluate the addition of paclitaxel to an anthracycline-based adjuvant regimen and to compare this combination with the same regimen given as primary systemic (neoadjuvant) therapy... 
Feasibility and tolerability of sequential doxorubicin/paclitaxel followed by cyclophosphamide, methotrexate, and fluorouracil and its effects on tumor response as preoperative therapyLuca Gianni
Istituto Nazionale Tumori, Milan, Italy, and Hospital Vall d Hebron, Barcelona, Spain
Clin Cancer Res 11:8715-21. 2005..We report here feasibility, tolerability, locoregional antitumor activity, and breast conservation rate...- Capecitabine/Cyclophosphamide/Methotrexate for patients with metastatic breast cancer: a dose-finding, feasibility, and efficacy studyGabriella Mariani
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Clin Breast Cancer 7:321-5. 2006.... - Role of anthracyclines in the treatment of early breast cancerLuca Gianni
Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
J Clin Oncol 27:4798-808. 2009..To review data relating to anthracyclines in the adjuvant treatment of early breast cancer... - International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010)Alfredo Berruti
Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Azienda Ospedaliera Universitaria San Luigi di Orbassano, Orbassano, Italy
J Natl Cancer Inst Monogr 2011:147-51. 2011..Changes in tumor biology after PST are an early phenomenon; so, an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials... 
Anthracycline cardiotoxicity: from bench to bedsideLuca Gianni
Division of Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori, Milan, Italy
J Clin Oncol 26:3777-84. 2008..Here, we incorporate these discussions into the framework of a broader review of preclinical and clinical issues...- Surrogate markers for targeted therapy-based treatment activity and efficacyGiampaolo Bianchini
Department of Medical Oncology, hSR San Raffaele, Via Olgettina 60, Milano 20132, Italy
J Natl Cancer Inst Monogr 2011:91-4. 2011..Until now, clinically useful and validated predictive markers for targeted therapy are rare, but appropriate investigations in neoadjuvant studies will likely change this... - Prognostic and therapeutic implications of distinct kinase expression patterns in different subtypes of breast cancerGiampaolo Bianchini
Division of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Cancer Res 70:8852-62. 2010..Taken together, our results indicate that kinases regulating mitosis and immune functions convey distinct prognostic information that varies by clinical subtype... - Long-term results of a combination of paclitaxel, cisplatin and gemcitabine for salvage therapy in male germ-cell tumoursNicola Nicolai
Urology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
BJU Int 104:340-6. 2009.... - AnthracyclinesLuca Gianni
Division of Medical Oncology A, Istituto Nazionale Tumori, Milan, Italy
Cancer Chemother Biol Response Modif 21:29-40. 2003 - Clinical relevance of different sequencing of doxorubicin and cyclophosphamide, methotrexate, and Fluorouracil in operable breast cancerGianni Bonadonna
Department of Medical Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
J Clin Oncol 22:1614-20. 2004..To assess the clinical relevance of different sequences of doxorubicin (DOX) and cyclophosphamide, methotrexate, and fluorouracil (CMF) in patients with operable breast cancer at risk of disease relapse... - Pilot trial of trastuzumab starting with or after the doxorubicin component of a doxorubicin plus paclitaxel regimen for women with HER2-positive advanced breast cancerGiulia Bianchi
Istituto Nazionale Tumori, Milan, Italy
Clin Cancer Res 9:5944-51. 2003..Congestive heart failure was not observed, and LVEF decreases were reversible. Further studies of this regimen are warranted... - Targeting TRAIL agonistic receptors for cancer therapyCarmelo Carlo Stella
Cristina Gandini Medical Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
Clin Cancer Res 13:2313-7. 2007..The clinical translation of cell and gene therapy approaches represent a challenging strategy that might achieve systemic tumor targeting and increased intratumor delivery of the therapeutic agent...