Rossella Galli

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system
    Rossella Galli
    Stem Cell Research Institute, H S Raffaele, Via Olgettina 58, Milan, I 20132, Italy
    Development 129:1633-44. 2002
  2. ncbi request reprint Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    Rossella Galli
    Stem Cell Research Institute and Laboratory of Molecular Diagnostics, H S Raffaele, Milan, Italy
    Cancer Res 64:7011-21. 2004
  3. doi request reprint Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions
    Laura Magri
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Cell Stem Cell 9:447-62. 2011
  4. ncbi request reprint Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons
    Elena Colombo
    Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:631-9. 2004
  5. ncbi request reprint Defective postnatal neurogenesis and disorganization of the rostral migratory stream in absence of the Vax1 homeobox gene
    José Miguel Soria
    Dulbecco Telethon Institute at Consiglio Nazionale delle Ricerche Istituto di Tecnologie Biomediche, 20090 Segrate, Milan, Italy
    J Neurosci 24:11171-81. 2004
  6. doi request reprint Adult neural stem cells
    Rossella Galli
    Stem Cell Research Institute HSR SCRI, DIBI H S Raffaele, Milan, Italy
    Methods Mol Biol 438:67-84. 2008
  7. doi request reprint Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of tuberous sclerosis complex
    Marco Cambiaghi
    San Raffaele Scientific Institute, Milan, Italy
    Neuropharmacology 67:1-7. 2013
  8. ncbi request reprint Resilience to transformation and inherent genetic and functional stability of adult neural stem cells ex vivo
    Chiara Foroni
    Stem Cell Research Institute DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 67:3725-33. 2007
  9. ncbi request reprint Neural stem cells in the adult nervous system
    Daniele Bottai
    Stem Cell Research Institute, DIBIT, Fondazione Centro San Raffaele del Monte Tabor, 20132 Milan, Italy
    J Hematother Stem Cell Res 12:655-70. 2003
  10. doi request reprint Clonal analyses and cryopreservation of neural stem cell cultures
    Angela Gritti
    Telethon Institute for Gene Therapy, DIBIT San Raffaele Scientific Institute, Milan, Italy
    Methods Mol Biol 438:173-84. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system
    Rossella Galli
    Stem Cell Research Institute, H S Raffaele, Via Olgettina 58, Milan, I 20132, Italy
    Development 129:1633-44. 2002
    ..Rather, when Emx2 expression is abolished, the frequency of symmetric divisions that generate two stem cells increases, whereas it decreases when Emx2 expression is enhanced...
  2. ncbi request reprint Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    Rossella Galli
    Stem Cell Research Institute and Laboratory of Molecular Diagnostics, H S Raffaele, Milan, Italy
    Cancer Res 64:7011-21. 2004
    ..Thus, cells possessing all of the characteristics expected from tumor neural stem cells seem to be involved in the growth and recurrence of adult human glioblastomas multiforme...
  3. doi request reprint Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions
    Laura Magri
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Cell Stem Cell 9:447-62. 2011
    ..Thus, finely tuned mTOR activation in embryonic NSCs may be critical to prevent development of TSC-associated brain lesions...
  4. ncbi request reprint Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons
    Elena Colombo
    Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:631-9. 2004
    ..In conclusion, our mouse Arx expression data provide important further insights into the puzzling complexity of the human ARX mutation pleiotropy...
  5. ncbi request reprint Defective postnatal neurogenesis and disorganization of the rostral migratory stream in absence of the Vax1 homeobox gene
    José Miguel Soria
    Dulbecco Telethon Institute at Consiglio Nazionale delle Ricerche Istituto di Tecnologie Biomediche, 20090 Segrate, Milan, Italy
    J Neurosci 24:11171-81. 2004
    ..Together, these data indicate that Vax1 is a potent regulator of SVZ organization and NSC proliferation, with important consequences on postnatal neurogenesis...
  6. doi request reprint Adult neural stem cells
    Rossella Galli
    Stem Cell Research Institute HSR SCRI, DIBI H S Raffaele, Milan, Italy
    Methods Mol Biol 438:67-84. 2008
    ..The proper application of this method to the cells allows the establishment of long-term expanding stable NSC lines, starting from different neural tissues as the adult rodent CNS and human brain tumor specimens...
  7. doi request reprint Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of tuberous sclerosis complex
    Marco Cambiaghi
    San Raffaele Scientific Institute, Milan, Italy
    Neuropharmacology 67:1-7. 2013
    ....
  8. ncbi request reprint Resilience to transformation and inherent genetic and functional stability of adult neural stem cells ex vivo
    Chiara Foroni
    Stem Cell Research Institute DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 67:3725-33. 2007
    ..In conclusion, besides a plentiful and safe source of cells for therapeutic applications, ANSCs provide an ideal model to study aging and cancer in the context of stemness...
  9. ncbi request reprint Neural stem cells in the adult nervous system
    Daniele Bottai
    Stem Cell Research Institute, DIBIT, Fondazione Centro San Raffaele del Monte Tabor, 20132 Milan, Italy
    J Hematother Stem Cell Res 12:655-70. 2003
    ....
  10. doi request reprint Clonal analyses and cryopreservation of neural stem cell cultures
    Angela Gritti
    Telethon Institute for Gene Therapy, DIBIT San Raffaele Scientific Institute, Milan, Italy
    Methods Mol Biol 438:173-84. 2008
    ..We illustrate and discuss methods for the isolation, propagation, cryopreservation, and functional characterization of NSCs, focusing on the essential issue of their clonogenic capacity...
  11. ncbi request reprint Embryonic stem-derived versus somatic neural stem cells: a comparative analysis of their developmental potential and molecular phenotype
    Elena Colombo
    Stem Cell Research Department, Dipartmento di Biotecnologie, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Stem Cells 24:825-34. 2006
    ..This may contribute to the high proliferation rate exhibited by these cells in culture...
  12. ncbi request reprint Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
    Stefano Pluchino
    Neuroimmunology Unit DIBIT, San Raffaele Hospital, Via Olgettina 58, 20132 Milano, Italy
    Nature 422:688-94. 2003
    ..Thus, adult neural precursor cells promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis...
  13. ncbi request reprint Neural stem cells: plasticity and their transdifferentiation potential
    Angelo Vescovi
    Stem Cell Research Institute, DIBIT H San Raffaele, Milan, Italy
    Cells Tissues Organs 171:64-76. 2002
    ..In this article, we review some of the basic notions regarding the functional properties of the adult neural stem cells and discuss findings in the expanding area of trans-germ layer conversion, with emphasis on the neural stem cell...
  14. pmc Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models
    Laura Magri
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy
    Dis Model Mech 6:1185-97. 2013
    ....
  15. ncbi request reprint Neural stem cells: an overview
    Rossella Galli
    Stem Cell Research Institute, DIBIT, Hospital San Raffaele, Via Olgettina 58, Milan, Italy
    Circ Res 92:598-608. 2003
    ..A critical discussion of the latest, controversial findings regarding this surprising phenomenon is provided...
  16. ncbi request reprint Clonal analyses and cryopreservation of neural stem cell cultures
    Angelo L Vescovi
    Institute for Stem Cell Research, Ospedale San Raffaele, Milan, Italy
    Methods Mol Biol 198:115-23. 2002
  17. pmc Gene signatures distinguish stage-specific prostate cancer stem cells isolated from transgenic adenocarcinoma of the mouse prostate lesions and predict the malignancy of human tumors
    Stefania Mazzoleni
    San Raffaele Scientific Institute, Milan, Italy
    Stem Cells Transl Med 2:678-89. 2013
    ....
  18. doi request reprint Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification
    Daniela Corno
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientifi c Institute, Via Olgettina 58, 20132 Milan, Italy
    Cancer Discov 2:554-68. 2012
    ....
  19. doi request reprint Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis
    Stefania Mazzoleni
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 70:7500-13. 2010
    ..These findings open up the possibility of new therapeutically relevant scenarios, as the presence of functionally heterogeneous EGFR(pos) and EGFR(neg) TIC subpopulations within the same tumor might affect clinical response to treatment...
  20. pmc Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice
    Raffaella Melzi
    San Raffaele Diabetes Research Institute HSR DRI, Division of Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 5:e10357. 2010
    ..The aim of this study was to define whether NPC administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model...
  21. ncbi request reprint Gliomagenesis: a game played by few players or a team effort?
    Stefania Mazzoleni
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Front Biosci (Elite Ed) 4:205-13. 2012
    ..Finally, we discuss the clinical implications and the novel therapeutic scenarios that have been put forward by the presence of functionally and molecularly distinct subpopulations of GBM-initiating cells within the same tumor...
  22. pmc Immunobiological characterization of cancer stem cells isolated from glioblastoma patients
    Tiziano Di Tomaso
    Department of Pathology, San Raffaele Foundation Scientific Institute, Milan, Italy
    Clin Cancer Res 16:800-13. 2010
    ..The aims of this study were the immunobiological characterization of GBM CSCs and the assessment of whether these cells represent suitable targets for immunotherapy...
  23. doi request reprint Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
    Michele De Palma
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, 20132 Milano, Italy
    Cancer Cell 14:299-311. 2008
    ..These results illustrate the therapeutic potential of gene- and cell-based IFN-alpha delivery and should allow the development of IFN treatments that more effectively treat cancer...
  24. ncbi request reprint Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents
    Angela Gritti
    Institute for Stem Cell Research, Department of Biotechnology, San Raffaele Hospital, 20132 Milan, Italy
    J Neurosci 22:437-45. 2002
    ..These findings demonstrate that stem cells are not confined to the forebrain periventricular region and indicate that stem cells endowed with different functional characteristics occur at different levels of the SVZ-RE pathway...
  25. ncbi request reprint Monoclonal antibodies conjugated with superparamagnetic iron oxide particles allow magnetic resonance imaging detection of lymphocytes in the mouse brain
    Alessandro Luchetti
    Department of Clinical Neuroimmunology, San Raffaele Scientific Institute, Milan, Italy
    Mol Imaging 11:114-25. 2012
    ..Our findings suggest that indirect binding of the antibody to a streptavidinated particle allows for enhanced particle vectorialization compared to covalent binding of the antibody to the particle...
  26. doi request reprint The synthetic purine reversine selectively induces cell death of cancer cells
    Marco Piccoli
    Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Milan, Italy
    J Cell Biochem 113:3207-17. 2012
    ..However, they can be induced to become sensitive to the molecule when key cell cycle proteins, e.g., p53, are silenced...
  27. ncbi request reprint Adult neural stem cells: plasticity and developmental potential
    Angela Gritti
    Institute for Stem Cell Research, DIBIT, S Raffaele Hospital, Via Olgettina 58, Milan, Italy
    J Physiol Paris 96:81-90. 2002
    ....
  28. doi request reprint The neurosphere assay applied to neural stem cells and cancer stem cells
    Rossella Galli
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Methods Mol Biol 986:267-77. 2013
    ..Here we describe the methods currently employed to enrich for NSCs/CSCs based on the NeuroSphere Assay (NSA) and their adaptation to specific assays for testing the efficacy of neuroactive compounds...
  29. doi request reprint mTOR signaling in neural stem cells: from basic biology to disease
    Laura Magri
    Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Cell Mol Life Sci 70:2887-98. 2013
    ..Here we review recent advances in the molecular dissection of the mTOR cascade, its involvement in the maintenance of stem cell compartments, and in particular the implications of mTOR hyperactivation in NSCs in vivo and in vitro. ..
  30. pmc Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival
    Elena Riccitelli
    Department of Medical Biotechnology and Translational Medicine, University of Milan, LITA Segrate, Milan, Italy
    PLoS ONE 8:e68229. 2013
    ..Altogether our data implicate for the first time GSCs as a pivotal source of extracellular S1P, which might act as an autocrine/paracrine signal contributing to their malignant properties. ..
  31. pmc Mash1 specifies neurons and oligodendrocytes in the postnatal brain
    Carlos M Parras
    Institut de Génétique et de Biologie Cellulaire et Moléculaire, Illkirch, France
    EMBO J 23:4495-505. 2004
    ....
  32. ncbi request reprint Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    Michele De Palma
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Milano, Italy
    Cancer Cell 8:211-26. 2005
    ..Therefore, Tie2 expression characterizes three distinct cell types required for tumor neovascularization: ECs, proangiogenic cells of hematopoietic origin, and pericyte precursors of mesenchymal origin...
  33. ncbi request reprint Brain tumour stem cells
    Angelo L Vescovi
    Department of Biotechnology and Biosciences, University of Milan Bicocca, Milan 20126, Italy
    Nat Rev Cancer 6:425-36. 2006
    ..The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies...