Massimo Filippi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
  2. ncbi request reprint Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
  3. ncbi request reprint A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS
    V Martinelli
    Department of Neurology, Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 73:1842-8. 2009
  4. ncbi request reprint Role of magnetic resonance imaging in the diagnosis and monitoring of multiple sclerosis: consensus report of the White Matter Study Group
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University San Raffaele, Milan, Italy
    J Magn Reson Imaging 15:499-504. 2002
  5. ncbi request reprint A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
  6. ncbi request reprint Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
  7. ncbi request reprint The topography of brain damage at different stages of Parkinson's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Hum Brain Mapp 34:2798-807. 2013
  8. doi request reprint Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
  9. ncbi request reprint The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
  10. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007

Collaborators

Detail Information

Publications181 found, 100 shown here

  1. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  2. ncbi request reprint Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
    ..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex...
  3. ncbi request reprint A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS
    V Martinelli
    Department of Neurology, Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 73:1842-8. 2009
    ..To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse...
  4. ncbi request reprint Role of magnetic resonance imaging in the diagnosis and monitoring of multiple sclerosis: consensus report of the White Matter Study Group
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University San Raffaele, Milan, Italy
    J Magn Reson Imaging 15:499-504. 2002
    ....
  5. ncbi request reprint A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
    ..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology...
  6. ncbi request reprint Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
    ....
  7. ncbi request reprint The topography of brain damage at different stages of Parkinson's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Hum Brain Mapp 34:2798-807. 2013
    ..WM abnormalities beyond the nigrostriatal system accumulate with increasing PD severity. WM damage is likely to contribute to the more severe motor and nonmotor dysfunctions occurring in patients at the later stages...
  8. doi request reprint Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
    ..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS...
  9. ncbi request reprint The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
    ..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status...
  10. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  11. ncbi request reprint Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Movement-associated cortical reorganisation is known to occur in multiple sclerosis (MS). We aimed to define the development of such cortical reorganisation by comparing data from patients with different disease phenotypes...
  12. doi request reprint White matter microstructural damage in Alzheimer's disease at different ages of onset
    Elisa Canu
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurobiol Aging 34:2331-40. 2013
    ..In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups. ..
  13. ncbi request reprint A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...
  14. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  15. ncbi request reprint Brain macro- and microscopic damage in patients with paediatric MS
    Martina Absinta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:1357-62. 2010
    ....
  16. ncbi request reprint Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues...
  17. ncbi request reprint Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Maria A Rocca
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 18:847-55. 2003
    ..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage...
  18. ncbi request reprint Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2844-51. 2009
    ....
  19. doi request reprint A three-year, multi-parametric MRI study in patients at presentation with CIS
    Maria A Rocca
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale, San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    J Neurol 255:683-91. 2008
    ..To define the extent of overall brain damage in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to identify non-conventional magnetic resonance (MR) metrics predictive of evolution to definite MS...
  20. ncbi request reprint Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  21. doi request reprint Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI study
    Maria Assunta Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 256:470-82. 2009
    ....
  22. doi request reprint Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 31:515-25. 2010
    ....
  23. ncbi request reprint Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:803-8. 2005
    ..Diffusion-tensor (DT) magnetic resonance imaging (MRI) has the potential to elucidate some characteristics of tissue microstructure inaccessible to other MRI techniques...
  24. doi request reprint Thalamic damage and long-term progression of disability in multiple sclerosis
    Maria Assunta Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 257:463-9. 2010
    ....
  25. doi request reprint Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
    Gianna Riccitelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 32:1535-43. 2011
    ..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype...
  26. ncbi request reprint Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:898-902. 2005
    ..Proton magnetic resonance spectroscopy (1H-MRS) can be used to measure in vivo whole-brain N-acetylaspartate (WBNAA) concentrations, the decrease of whose levels is considered a marker of neuronal-axonal injury...
  27. doi request reprint Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre study
    Marco Rovaris
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Mult Scler 17:319-26. 2011
    ..We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course...
  28. ncbi request reprint Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study
    Maria A Rocca
    Neuroimaging Research Unit, Vita Salute San Raffaele University, Italy
    Mult Scler 19:1610-7. 2013
    ..Optic radiation (OR) damage occurs in multiple sclerosis (MS)...
  29. ncbi request reprint Functional network connectivity in the behavioral variant of frontotemporal dementia
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Electronic address
    Cortex 49:2389-401. 2013
    ....
  30. doi request reprint Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis
    Paola Valsasina
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    Hum Brain Mapp 33:2072-80. 2012
    ....
  31. ncbi request reprint A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 65:1223-30. 2008
    ..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity...
  32. ncbi request reprint Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  33. ncbi request reprint Evidence for cervical cord tissue disorganisation with aging by diffusion tensor MRI
    Federica Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 36:728-35. 2007
    ..22, p=0.04) as independent correlates of age (r2=0.76). Cervical cord is vulnerable to aging. The decrease of FA, in the absence of atrophy and MD changes, suggests gliosis as the most likely pathological feature of the aging cord...
  34. ncbi request reprint Assessment of brain white matter fiber bundle atrophy in patients with Friedreich ataxia
    Elisabetta Pagani
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 255:882-9. 2010
    ....
  35. ncbi request reprint MRI predictors of long-term evolution in amyotrophic lateral sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Eur J Neurosci 32:1490-6. 2010
    ..56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity...
  36. doi request reprint Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
    Mult Scler 17:702-7. 2011
    ....
  37. doi request reprint Primary progressive multiple sclerosis: tactile-associated functional MR activity in the cervical spinal cord
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, 20132 Milan, Italy
    Radiology 253:209-15. 2009
    ....
  38. doi request reprint A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up
    Elisa Scola
    Neuroradiology Unit and CERMAC, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol Neurosurg Psychiatry 81:798-805. 2010
    ....
  39. ncbi request reprint Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Eur J Neurosci 31:1273-80. 2010
    ..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions...
  40. ncbi request reprint Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up study
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1378-83. 2008
    ..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease...
  41. ncbi request reprint Relationship between damage to the cerebellar peduncles and clinical disability in multiple sclerosis
    Paolo Preziosa
    From the Neuroimaging Research Unit P P, M A R, E P, M F and Department of Neurology P P, M A R, M F, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Clinics of Neurology S M, J Drulovic, J Dackovic and Radiology T S O, Faculty of Medicine, University of Belgrade, Belgrade, Serbia Biostatistics Unit, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy M C and Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy D C
    Radiology 271:822-30. 2014
    ..To assess whether a structural disconnection between the cerebellum and the cerebral hemispheres contributes to cerebellar and brainstem symptoms in multiple sclerosis (MS)...
  42. doi request reprint Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
    ....
  43. doi request reprint Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study
    Paolo Preziosa
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Radiology 260:541-50. 2011
    ....
  44. ncbi request reprint MRI and the diagnosis of multiple sclerosis: expanding the concept of "no better explanation"
    Arnaud Charil
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:841-52. 2006
    ..In this review we will report on the conclusions of this international consensus, which should represent a first step beyond the concept of "no better explanation", and inform future diagnostic criteria for multiple sclerosis...
  45. ncbi request reprint Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonia Ceccarelli
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 16:39-44. 2010
    ..42; p = 0.02). In CIS patients, deep GM is not spared, suggesting that iron-related changes and neurodegeneration occurs early. The magnitude of such damage is only minor and not associated with an increased risk of evolution to CDMS...
  46. ncbi request reprint Short-term accrual of gray matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 24:1139-46. 2005
    ..These observations suggest that progressive NAGM damage might yet be an additional factor leading to the accumulation of disability in progressive MS...
  47. ncbi request reprint Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    Paola Valsasina
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neuroimage 26:822-8. 2005
    ....
  48. ncbi request reprint Assessing atrophy of the major white matter fiber bundles of the brain from diffusion tensor MRI data
    Elisabetta Pagani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Magn Reson Med 58:527-34. 2007
    ..The effectiveness of the method was then tested on data from five patients with multiple sclerosis (MS) and two patients with amyotrophic lateral sclerosis (ALS)...
  49. doi request reprint A multicentre study of motor functional connectivity changes in patients with multiple sclerosis
    Paola Valsasina
    Division of Neuroscience, Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Eur J Neurosci 33:1256-63. 2011
    ..They further suggest that multicentre fMRI studies of FC changes are possible, and provide a potential imaging biomarker for use in experimental therapeutic studies directed at enhancing adaptive plasticity in the disease...
  50. ncbi request reprint Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:2323-32. 2003
    ....
  51. ncbi request reprint A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 19:1770-7. 2003
    ..It also suggests that, in these patients, functional abilities are sustained by increased recruitment of highly specialized cortical areas...
  52. doi request reprint A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  53. ncbi request reprint Brain network connectivity assessed using graph theory in frontotemporal dementia
    Federica Agosta
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurology 81:134-43. 2013
    ..To investigate whether brain functional network connectivity is disrupted in patients with the behavioral variant of frontotemporal dementia (bvFTD)...
  54. ncbi request reprint Differential cerebellar functional interactions during an interference task across multiple sclerosis phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Department of Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy
    Radiology 265:864-73. 2012
    ..To determine whether modification of the connections between cerebellar and prefrontal areas might vary among multiple sclerosis (MS) phenotypes and might be associated with cognitive failure...
  55. pmc The cortical signature of amyotrophic lateral sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 7:e42816. 2012
    ..Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression...
  56. doi request reprint Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis
    Maria A Rocca
    Department of Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurology 79:1449-57. 2012
    ..To this aim, we assessed, using resting-state (RS) fMRI, intrinsic FC and functional network connectivity (FNC) of brain large-scale neuronal networks from 85 patients with relapsing-remitting MS (RRMS) and 40 matched controls...
  57. pmc Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    PLoS ONE 5:e10198. 2010
    ..The scheme applied during the learning phase influences the pattern of such structural changes...
  58. doi request reprint Functional MR imaging correlates of neuropsychological impairment in primary-progressive multiple sclerosis
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 31:1240-6. 2010
    ..Cognitive deficits affect <or=30% of patients with PPMS. We investigated the functional correlates of cognitive network dysfunction in patients with PPMS and their correlation with the extent of structural MR imaging damage...
  59. ncbi request reprint Intercenter differences in diffusion tensor MRI acquisition
    Elisabetta Pagani
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, 20132 Milan, Italy
    J Magn Reson Imaging 31:1458-68. 2010
    ..To assess the effect on diffusion tensor (DT) magnetic resonance imaging (MRI) of acquiring data with different scanners...
  60. ncbi request reprint Secondary progressive multiple sclerosis: current knowledge and future challenges
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:343-54. 2006
    ....
  61. ncbi request reprint Normal-appearing white and grey matter damage in MS. A volumetric and diffusion tensor MRI study at 3.0 Tesla
    Antonia Ceccarelli
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 254:513-8. 2007
    ..Although histopathology was not available, axonal and neuronal damage and consequent reactive glial proliferation are the most likely substrates of the changes observed...
  62. doi request reprint A 3-year diffusion tensor MRI study of grey matter damage progression during the earliest clinical stage of MS
    Marco Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1209-14. 2008
    ....
  63. doi request reprint White matter damage in Alzheimer disease and its relationship to gray matter atrophy
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 258:853-63. 2011
    ....
  64. ncbi request reprint A composite score to predict short-term disease activity in patients with relapsing-remitting MS
    Maria Pia Sormani
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Neurology 69:1230-5. 2007
    ..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term...
  65. ncbi request reprint Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..We also investigated whether the extent of brain activations was correlated with WM structural pathology measured using diffusion tensor (DT) MRI...
  66. ncbi request reprint Simple and complex movement-associated functional MRI changes in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 21:108-17. 2004
    ..Local synaptic reorganization, recruitment of parallel existing pathways, and reorganization of distant sites are all likely to contribute to the observed functional changes. Hum. Brain Mapping 21:106-115, 2004...
  67. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  68. ncbi request reprint Influence of body segment position during in-phase and antiphase hand and foot movements: a kinematic and functional MRI study
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:218-27. 2007
    ..In addition to the relative difficulty of the movement, the different cognitive and sensorial loads needed to control and perform the motor act might be responsible for these findings...
  69. ncbi request reprint Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis
    Federica Agosta
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2620-7. 2006
    ..This study also suggests that GM damage is one of the key factors associated with disability accumulation in this 'white matter' condition...
  70. ncbi request reprint A functional MRI study of cortical activations associated with object manipulation in patients with MS
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, 20132 Milan, Italy
    Neuroimage 21:1147-54. 2004
    ....
  71. doi request reprint Phase III dose-comparison study of glatiramer acetate for multiple sclerosis
    Giancarlo Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Ann Neurol 69:75-82. 2011
    ..To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg compared to a 20mg dose...
  72. ncbi request reprint Tactile-associated fMRI recruitment of the cervical cord in healthy subjects
    Federica Agosta
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:340-5. 2009
    ..This holds significant promise for a better planning and conduct of studies of people with diseased spinal cords...
  73. ncbi request reprint Tactile-associated recruitment of the cervical cord is altered in patients with multiple sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1542-8. 2008
    ..In MS patients, the over-recruitment of the ipsilateral posterior cervical cord associated to a reduced functional lateralization suggests an abnormal function of the spinal relay interneurons...
  74. ncbi request reprint Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 14:455-64. 2008
    ..Sequence-related variability of measurements makes the standardization of MT MRI acquisition essential for the design of multicentre studies...
  75. ncbi request reprint Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  76. doi request reprint Bimonthly assessment of magnetization transfer magnetic resonance imaging parameters in multiple sclerosis: a 14-month, multicentre, follow-up study
    S Mesaros
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, 20132 Milan Italy
    Mult Scler 16:325-31. 2010
    ..The steady correlation observed between conventional and MT MRI measures over time supports the hypothesis of axonal degeneration of fibres passing through focal lesions as one of the factors contributing to the overall MS burden...
  77. ncbi request reprint The use of modern magnetic resonance techniques to monitor disease evolution in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Adv Neurol 98:167-83. 2006
  78. ncbi request reprint The "mirror-neuron system" in MS: A 3 tesla fMRI study
    M A Rocca
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 70:255-62. 2008
    ..We used functional MRI (fMRI) to investigate the properties of the MNS in patients with multiple sclerosis (MS)...
  79. doi request reprint Default-mode network dysfunction and cognitive impairment in progressive MS
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 74:1252-9. 2010
    ....
  80. doi request reprint Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  81. ncbi request reprint In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  82. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  83. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  84. ncbi request reprint The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    M Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 60:853-60. 2003
    ..Magnetization transfer (MT) MRI can provide in vivo markers reflecting the severity of irreversible, MS-related brain damage occurring within and outside T2-visible lesions...
  85. ncbi request reprint Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  86. ncbi request reprint Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis
    M P Sormani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 62:1432-4. 2004
    ..As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients...
  87. doi request reprint Cortical lesions in children with multiple sclerosis
    M Absinta
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 76:910-3. 2011
    ..We evaluated the presence and frequency of CLs in pediatric patients with relapsing-remitting MS (RRMS) in comparison to adult patients with MS with the same clinical phenotype...
  88. ncbi request reprint Long-term follow-up of patients treated with glatiramer acetate: a multicentre, multinational extension of the European/Canadian double-blind, placebo-controlled, MRI-monitored trial
    M Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 13:502-8. 2007
    ..An earlier initiation of GA treatment in patients with active RRMS might, at least partially, have a favourable impact on long-term disease evolution...
  89. ncbi request reprint MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis
    P Tortorella
    Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol 253:903-7. 2006
    ..Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS...
  90. ncbi request reprint Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI
    B Benedetti
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 67:161-3. 2006
    ..008) and average fractional anisotropy (p = 0.04). There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity (r = 0.52, p = 0.02)...
  91. doi request reprint MRI features of benign multiple sclerosis: toward a new definition of this disease phenotype
    M Rovaris
    Multiple Sclerosis Centre, Scientific Institute Santa Maria Nascente, Fondazione Don Gnocchi, Milan, Italy
    Neurology 72:1693-701. 2009
    ..In addition, the results of correlative MRI/neuropsychology studies underpin the need for a new definition of BMS, which should consider the maintenance of a normal cognitive profile as an additional criterion...
  92. ncbi request reprint Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI
    F Agosta
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 64:631-5. 2005
    ..To investigate the extent and severity of cervical cord damage using diffusion tensor MRI (DT-MRI) and histogram analysis in patients with primary progressive MS (PPMS)...
  93. ncbi request reprint Immunological patterns identifying disease course and evolution in multiple sclerosis patients
    Roberto Furlan
    Neuroimmunology Unit, San Raffaele, Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Neuroimmunol 165:192-200. 2005
    ....
  94. ncbi request reprint Adaptive functional changes in the cerebral cortex of patients with nondisabling multiple sclerosis correlate with the extent of brain structural damage
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, University Ospedale, San Raffaele, Milan, Italy
    Ann Neurol 51:330-9. 2002
    ..It also suggests that increased recruitment of this cortical network contributes to the limitation of the functional impact of white matter multiple sclerosis injury...
  95. ncbi request reprint Magnetic resonance imaging of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neuroimaging 12:289-301. 2002
    ....
  96. ncbi request reprint Occult tissue damage in patients with primary progressive multiple sclerosis is independent of T2-visible lesions--a diffusion tensor MR study
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 250:456-60. 2003
    ..This suggests that Wallerian degeneration of fibers passing through macroscopic abnormalities is not a major factor contributing to diffuse NABT pathology of these patients...
  97. ncbi request reprint Magnetization transfer magnetic resonance imaging of the brain, spinal cord, and optic nerve
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Neurotherapeutics 4:401-13. 2007
    ..MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials...
  98. ncbi request reprint Interventions for the prevention of brain atrophy in multiple sclerosis : current status
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    CNS Drugs 17:563-75. 2003
    ....
  99. ncbi request reprint Headache and migraine
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurol Sci 29:336-8. 2008
    ..More recently, it has been suggested that the different forms of headache/migraine might have specific functional and structural MRI correlates, which, in the future, is likely to result in new therapeutic scenarios...
  100. ncbi request reprint The use of quantitative magnetic-resonance-based techniques to monitor the evolution of multiple sclerosis
    Massimo Filippi
    Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 2:337-46. 2003
    ..These techniques are substantially changing our understanding of how MS causes irreversible disability and should be used more extensively in clinical trials and in studies of disease progression...
  101. ncbi request reprint Can glatiramer acetate reduce brain atrophy development in multiple sclerosis?
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60 20132 Milan, Italy
    J Neurol Sci 233:139-43. 2005
    ..Further studies of adequate duration are now required to address this issue, as well as to confirm the sustained efficacy of GA treatment over long periods of follow-up...