Massimo Filippi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    PLoS ONE 6:e17081. 2011
  2. ncbi request reprint Guidelines from The Italian Neurological and Neuroradiological Societies for the use of magnetic resonance imaging in daily life clinical practice of multiple sclerosis patients
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurol Sci 34:2085-93. 2013
  3. doi request reprint Imaging resting state brain function in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 260:1709-13. 2013
  4. doi request reprint Future MRI tools in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    J Neurol Sci 331:14-8. 2013
  5. doi request reprint EFNS task force: the use of neuroimaging in the diagnosis of dementia
    M Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Eur J Neurol 19:e131-40, 1487-501. 2012
  6. doi request reprint Microstructural magnetic resonance imaging of cortical lesions in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan 20132, Italy
    Mult Scler 19:418-26. 2013
  7. doi request reprint The organization of intrinsic brain activity differs between genders: a resting-state fMRI study in a large cohort of young healthy subjects
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and Vita Salute University, Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 34:1330-43. 2013
  8. ncbi request reprint Magnetic resonance imaging in Alzheimer's disease: from diagnosis to monitoring treatment effect
    M Filippi
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
    Curr Alzheimer Res 9:1198-209. 2012
  9. ncbi request reprint Association between pathological and MRI findings in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute San Raffaele University, Milan, Italy
    Lancet Neurol 11:349-60. 2012
  10. doi request reprint Diffusion tensor MRI tractography and cognitive impairment in multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Neurology 78:969-75. 2012

Collaborators

Detail Information

Publications179 found, 100 shown here

  1. pmc Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    PLoS ONE 6:e17081. 2011
    ..Such abnormalities also involve the auditory network, thus corroborating the notion of a cross-modal plasticity between these sensory modalities in patients with severe visual deficits...
  2. ncbi request reprint Guidelines from The Italian Neurological and Neuroradiological Societies for the use of magnetic resonance imaging in daily life clinical practice of multiple sclerosis patients
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurol Sci 34:2085-93. 2013
    ..It also offers clues for the standardization of MRI studies and relative reporting to be applied at a national level...
  3. doi request reprint Imaging resting state brain function in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 260:1709-13. 2013
    ....
  4. doi request reprint Future MRI tools in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    J Neurol Sci 331:14-8. 2013
    ....
  5. doi request reprint EFNS task force: the use of neuroimaging in the diagnosis of dementia
    M Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Eur J Neurol 19:e131-40, 1487-501. 2012
    ....
  6. doi request reprint Microstructural magnetic resonance imaging of cortical lesions in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan 20132, Italy
    Mult Scler 19:418-26. 2013
    ..Pathologic and magnetic resonance imaging (MRI) studies have shown that cortical lesions (CLs) are a frequent finding in multiple sclerosis (MS)...
  7. doi request reprint The organization of intrinsic brain activity differs between genders: a resting-state fMRI study in a large cohort of young healthy subjects
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and Vita Salute University, Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 34:1330-43. 2013
    ..To investigate, using resting state (RS) functional MRI (fMRI), gender-related differences of functional connectivity (FC) and functional network connectivity (FNC) of the human brain...
  8. ncbi request reprint Magnetic resonance imaging in Alzheimer's disease: from diagnosis to monitoring treatment effect
    M Filippi
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
    Curr Alzheimer Res 9:1198-209. 2012
    ..This review summarizes the main results obtained from the application of conventional and non-conventional MRI in AD patients, and supports their more extensive use in studies of disease evolution and clinical trials...
  9. ncbi request reprint Association between pathological and MRI findings in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute San Raffaele University, Milan, Italy
    Lancet Neurol 11:349-60. 2012
    ..Despite these important achievements, numerous open questions still need to be addressed to resolve controversies about how the pathology of MS results in fixed neurological disability...
  10. doi request reprint Diffusion tensor MRI tractography and cognitive impairment in multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Neurology 78:969-75. 2012
    ..To assess the correlation between cognitive impairment and overall vs regional CNS damage, quantified using conventional and diffusion tensor (DT) MRI tractography in multiple sclerosis (MS)...
  11. doi request reprint Pattern of brain tissue loss associated with freezing of gait in Parkinson disease
    V S Kostic
    Department of Neurology, University of Belgrade, Belgrade, Serbia
    Neurology 78:409-16. 2012
    ..To investigate whether a specific pattern of gray matter (GM) tissue loss is associated with freezing of gait (FOG) in patients with Parkinson disease (PD)...
  12. ncbi request reprint European study on intravenous immunoglobulin in multiple sclerosis: results of magnetization transfer magnetic resonance imaging analysis
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 61:1409-12. 2004
    ..Magnetization transfer magnetic resonance imaging (MT MRI) can provide in vivo markers reflecting the severity of multiple sclerosis-related brain damage occurring within and outside T2-visible lesions...
  13. ncbi request reprint Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:433-7. 2003
    ..This finding lessens the validity of the current concept that the axonal pathology of multiple sclerosis is the end-stage result of repeated inflammatory events, and argues strongly in favour of early neuroprotective intervention...
  14. doi request reprint MR imaging of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 259:659-81. 2011
    ..The utility of these modern MR techniques in clinical trial monitoring and in the assessment of the individual patient's response to treatment still need to be evaluated...
  15. ncbi request reprint Magnetization transfer MRI in multiple sclerosis and other central nervous system disorders
    M Filippi
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Eur J Neurol 10:3-10. 2003
    ....
  16. ncbi request reprint Disturbed function and plasticity in multiple sclerosis as gleaned from functional magnetic resonance imaging
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Curr Opin Neurol 16:275-82. 2003
    ....
  17. ncbi request reprint Imaging biomarkers in multiple sclerosis
    M Filippi
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    J Magn Reson Imaging 31:770-88. 2010
    ....
  18. doi request reprint Novel MRI approaches to assess patients with multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Curr Opin Neurol 23:212-7. 2010
    ..This review summarizes novel MRI approaches for the investigation of lesion burden and understanding of the pathophysiology of multiple sclerosis (MS)...
  19. doi request reprint Structural and functional network connectivity breakdown in Alzheimer’s disease studied with magnetic resonance imaging techniques
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Alzheimers Dis 24:455-74. 2011
    ..This research endeavor holds a great promise in clarifying the mechanisms of cognitive decline in complex chronic neurodegenerative disorders...
  20. doi request reprint MR imaging of gray matter involvement in multiple sclerosis: implications for understanding disease pathophysiology and monitoring treatment efficacy
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 31:1171-7. 2010
    ....
  21. pmc The contribution of MRI in assessing cognitive impairment in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Neurology 75:2121-8. 2010
    ..Finally, the utility of the previous techniques to monitor the progression of cognitive deficits over time and the efficacy of possible therapeutic strategies is considered...
  22. pmc EFNS guidelines on the use of neuroimaging in the management of motor neuron diseases
    M Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Institute of Experimental Neurology, Milan, Italy
    Eur J Neurol 17:526-e20. 2010
    ....
  23. ncbi request reprint Simple and complex movement-associated functional MRI changes in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 21:108-17. 2004
    ..Local synaptic reorganization, recruitment of parallel existing pathways, and reorganization of distant sites are all likely to contribute to the observed functional changes. Hum. Brain Mapping 21:106-115, 2004...
  24. doi request reprint Magnetic resonance techniques in multiple sclerosis: the present and the future
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Vita Salute San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Arch Neurol 68:1514-20. 2011
    ..After a brief summary of the main results obtained from the established and emerging MR methods, this review discusses the steps needed before the latter become suitable for widespread use in the MS research community...
  25. doi request reprint MRI and cognition in multiple sclerosis
    M Filippi
    Division of Neuroscience, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Neurol Sci 31:S231-4. 2010
    ..In addition, the use of functional MRI has disclosed that brain cortical reorganization may play a role in limiting the neuropsychological consequences of structural damage in the different stages of the disease...
  26. ncbi request reprint The role of magnetic resonance imaging in the study of multiple sclerosis: diagnosis, prognosis and understanding disease pathophysiology
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Acta Neurol Belg 111:89-98. 2011
    ....
  27. pmc Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    PLoS ONE 5:e10198. 2010
    ..The scheme applied during the learning phase influences the pattern of such structural changes...
  28. ncbi request reprint A conventional and magnetization transfer MRI study of the cervical cord in patients with MS
    M Filippi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Neurology 54:207-13. 2000
    ..To evaluate the contribution made by cervical cord damage, assessed using a fast short-tau inversion recovery (fast-STIR) sequence and magnetization transfer ratio (MTR) histogram analysis to the clinical manifestations of MS...
  29. ncbi request reprint Overview of diffusion-weighted magnetic resonance studies in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    J Neurol Sci 186:S37-43. 2001
    ..The present review outlines the major contributions given by DW-MRI for the quantification of MS-related damage and for the understanding of MS pathophysiology...
  30. ncbi request reprint Whole brain volume changes in patients with progressive MS treated with cladribine
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Neurology 55:1714-8. 2000
    ..7 and 2.1 mg/kg) and to assess the correlations between change in whole brain volume and change in other conventional MRI measures...
  31. ncbi request reprint Magnetization transfer magnetic resonance imaging of the brain, spinal cord, and optic nerve
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Neurotherapeutics 4:401-13. 2007
    ..MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials...
  32. ncbi request reprint Magnetic resonance imaging of grey matter damage in people with MS
    M Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Int MS J 14:12-21. 2007
    ..MS is now viewed as a global CNS condition, affecting both WM and GM, which has an early and important neurodegenerative component...
  33. ncbi request reprint Magnetization transfer magnetic resonance imaging in the assessment of neurological diseases
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale, San Raffaele, Milan, Italy
    J Neuroimaging 14:303-13. 2004
    ....
  34. pmc Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy
    J Neurol Neurosurg Psychiatry 68:157-61. 2000
    ....
  35. ncbi request reprint A functional MRI study of cortical activations associated with object manipulation in patients with MS
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, 20132 Milan, Italy
    Neuroimage 21:1147-54. 2004
    ....
  36. ncbi request reprint Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
    ....
  37. ncbi request reprint Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Maria A Rocca
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 18:847-55. 2003
    ..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage...
  38. ncbi request reprint A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
    ..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology...
  39. ncbi request reprint Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Movement-associated cortical reorganisation is known to occur in multiple sclerosis (MS). We aimed to define the development of such cortical reorganisation by comparing data from patients with different disease phenotypes...
  40. ncbi request reprint The topography of brain damage at different stages of Parkinson's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Hum Brain Mapp 34:2798-807. 2013
    ..WM abnormalities beyond the nigrostriatal system accumulate with increasing PD severity. WM damage is likely to contribute to the more severe motor and nonmotor dysfunctions occurring in patients at the later stages...
  41. doi request reprint White matter microstructural damage in Alzheimer's disease at different ages of onset
    Elisa Canu
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurobiol Aging 34:2331-40. 2013
    ..In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups. ..
  42. doi request reprint Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
    ..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS...
  43. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  44. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  45. ncbi request reprint The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
    ..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status...
  46. ncbi request reprint A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...
  47. ncbi request reprint Brain macro- and microscopic damage in patients with paediatric MS
    Martina Absinta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:1357-62. 2010
    ....
  48. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  49. ncbi request reprint Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues...
  50. ncbi request reprint Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2844-51. 2009
    ....
  51. doi request reprint Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 31:515-25. 2010
    ....
  52. doi request reprint A three-year, multi-parametric MRI study in patients at presentation with CIS
    Maria A Rocca
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale, San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    J Neurol 255:683-91. 2008
    ..To define the extent of overall brain damage in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to identify non-conventional magnetic resonance (MR) metrics predictive of evolution to definite MS...
  53. ncbi request reprint Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  54. doi request reprint Gray matter damage predicts the accumulation of disability 13 years later in MS
    Massimo Filippi
    From the Neuroimaging Research Unit M F, P P, G R, M A R, Institute of Experimental Neurology, and Department of Neurology M F, P P, V M, G C, M A R, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan Biostatistics Unit M C, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy and Medical Physics Group M A H, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, UK
    Neurology 81:1759-67. 2013
    ....
  55. ncbi request reprint Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:803-8. 2005
    ..Diffusion-tensor (DT) magnetic resonance imaging (MRI) has the potential to elucidate some characteristics of tissue microstructure inaccessible to other MRI techniques...
  56. doi request reprint Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI study
    Maria Assunta Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 256:470-82. 2009
    ....
  57. doi request reprint Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre study
    Marco Rovaris
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Mult Scler 17:319-26. 2011
    ..We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course...
  58. doi request reprint Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
    Gianna Riccitelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 32:1535-43. 2011
    ..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype...
  59. ncbi request reprint Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  60. ncbi request reprint Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:898-902. 2005
    ..Proton magnetic resonance spectroscopy (1H-MRS) can be used to measure in vivo whole-brain N-acetylaspartate (WBNAA) concentrations, the decrease of whose levels is considered a marker of neuronal-axonal injury...
  61. ncbi request reprint Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..We also investigated whether the extent of brain activations was correlated with WM structural pathology measured using diffusion tensor (DT) MRI...
  62. doi request reprint Thalamic damage and long-term progression of disability in multiple sclerosis
    Maria Assunta Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 257:463-9. 2010
    ....
  63. ncbi request reprint Relationship between damage to the cerebellar peduncles and clinical disability in multiple sclerosis
    Paolo Preziosa
    From the Neuroimaging Research Unit P P, M A R, E P, M F and Department of Neurology P P, M A R, M F, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Clinics of Neurology S M, J Drulovic, J Dackovic and Radiology T S O, Faculty of Medicine, University of Belgrade, Belgrade, Serbia Biostatistics Unit, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy M C and Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy D C
    Radiology 271:822-30. 2014
    ..To assess whether a structural disconnection between the cerebellum and the cerebral hemispheres contributes to cerebellar and brainstem symptoms in multiple sclerosis (MS)...
  64. doi request reprint Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis
    Paola Valsasina
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    Hum Brain Mapp 33:2072-80. 2012
    ....
  65. ncbi request reprint Selective decreased grey matter volume of the pain-matrix network in cluster headache
    Martina Absinta
    Vita Salute San Raffaele University, Italy
    Cephalalgia 32:109-15. 2012
    ..We assessed the pattern of regional white matter and grey matter abnormalities in patients with cluster headache (CH), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM)...
  66. ncbi request reprint Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up study
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1378-83. 2008
    ..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease...
  67. ncbi request reprint MRI predictors of long-term evolution in amyotrophic lateral sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Eur J Neurosci 32:1490-6. 2010
    ..56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity...
  68. ncbi request reprint Evidence for cervical cord tissue disorganisation with aging by diffusion tensor MRI
    Federica Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 36:728-35. 2007
    ..22, p=0.04) as independent correlates of age (r2=0.76). Cervical cord is vulnerable to aging. The decrease of FA, in the absence of atrophy and MD changes, suggests gliosis as the most likely pathological feature of the aging cord...
  69. doi request reprint A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up
    Elisa Scola
    Neuroradiology Unit and CERMAC, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol Neurosurg Psychiatry 81:798-805. 2010
    ....
  70. doi request reprint Primary progressive multiple sclerosis: tactile-associated functional MR activity in the cervical spinal cord
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, 20132 Milan, Italy
    Radiology 253:209-15. 2009
    ....
  71. doi request reprint Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
    Mult Scler 17:702-7. 2011
    ....
  72. ncbi request reprint Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Eur J Neurosci 31:1273-80. 2010
    ..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions...
  73. ncbi request reprint Assessment of brain white matter fiber bundle atrophy in patients with Friedreich ataxia
    Elisabetta Pagani
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 255:882-9. 2010
    ....
  74. ncbi request reprint A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 65:1223-30. 2008
    ..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity...
  75. doi request reprint Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
    ....
  76. ncbi request reprint Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
    ..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex...
  77. ncbi request reprint MRI and the diagnosis of multiple sclerosis: expanding the concept of "no better explanation"
    Arnaud Charil
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:841-52. 2006
    ..In this review we will report on the conclusions of this international consensus, which should represent a first step beyond the concept of "no better explanation", and inform future diagnostic criteria for multiple sclerosis...
  78. ncbi request reprint Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:2323-32. 2003
    ....
  79. ncbi request reprint Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    Paola Valsasina
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neuroimage 26:822-8. 2005
    ....
  80. doi request reprint Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study
    Paolo Preziosa
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Radiology 260:541-50. 2011
    ....
  81. ncbi request reprint A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 19:1770-7. 2003
    ..It also suggests that, in these patients, functional abilities are sustained by increased recruitment of highly specialized cortical areas...
  82. ncbi request reprint Short-term accrual of gray matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 24:1139-46. 2005
    ..These observations suggest that progressive NAGM damage might yet be an additional factor leading to the accumulation of disability in progressive MS...
  83. doi request reprint A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  84. ncbi request reprint Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonia Ceccarelli
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 16:39-44. 2010
    ..42; p = 0.02). In CIS patients, deep GM is not spared, suggesting that iron-related changes and neurodegeneration occurs early. The magnitude of such damage is only minor and not associated with an increased risk of evolution to CDMS...
  85. ncbi request reprint Assessing atrophy of the major white matter fiber bundles of the brain from diffusion tensor MRI data
    Elisabetta Pagani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Magn Reson Med 58:527-34. 2007
    ..The effectiveness of the method was then tested on data from five patients with multiple sclerosis (MS) and two patients with amyotrophic lateral sclerosis (ALS)...
  86. ncbi request reprint Secondary progressive multiple sclerosis: current knowledge and future challenges
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:343-54. 2006
    ....
  87. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  88. ncbi request reprint Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  89. doi request reprint Bimonthly assessment of magnetization transfer magnetic resonance imaging parameters in multiple sclerosis: a 14-month, multicentre, follow-up study
    S Mesaros
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, 20132 Milan Italy
    Mult Scler 16:325-31. 2010
    ..The steady correlation observed between conventional and MT MRI measures over time supports the hypothesis of axonal degeneration of fibres passing through focal lesions as one of the factors contributing to the overall MS burden...
  90. ncbi request reprint A composite score to predict short-term disease activity in patients with relapsing-remitting MS
    Maria Pia Sormani
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Neurology 69:1230-5. 2007
    ..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term...
  91. ncbi request reprint The use of modern magnetic resonance techniques to monitor disease evolution in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Adv Neurol 98:167-83. 2006
  92. doi request reprint Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  93. ncbi request reprint The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    M Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 60:853-60. 2003
    ..Magnetization transfer (MT) MRI can provide in vivo markers reflecting the severity of irreversible, MS-related brain damage occurring within and outside T2-visible lesions...
  94. ncbi request reprint The "mirror-neuron system" in MS: A 3 tesla fMRI study
    M A Rocca
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 70:255-62. 2008
    ..We used functional MRI (fMRI) to investigate the properties of the MNS in patients with multiple sclerosis (MS)...
  95. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  96. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  97. ncbi request reprint Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  98. doi request reprint Default-mode network dysfunction and cognitive impairment in progressive MS
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 74:1252-9. 2010
    ....
  99. ncbi request reprint In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  100. doi request reprint MRI features of benign multiple sclerosis: toward a new definition of this disease phenotype
    M Rovaris
    Multiple Sclerosis Centre, Scientific Institute Santa Maria Nascente, Fondazione Don Gnocchi, Milan, Italy
    Neurology 72:1693-701. 2009
    ..In addition, the results of correlative MRI/neuropsychology studies underpin the need for a new definition of BMS, which should consider the maintenance of a normal cognitive profile as an additional criterion...
  101. ncbi request reprint MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis
    P Tortorella
    Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol 253:903-7. 2006
    ..Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS...