Research Topics
Species | Massimo FilippiSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Detail Information
Publications
Vitamin A: yet another player in multiple sclerosis pathogenesis?Massimo Filippi
Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
Expert Rev Clin Immunol 9:113-5. 2013..Following IFN-β-1a treatment, the association with MRI metrics was lost. These results support a role of vitamin A metabolites in influencing disease activity in MS...- Voxel-wise mapping of cervical cord damage in multiple sclerosis patients with different clinical phenotypesMaria A Rocca
Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60 20132 Milan, Italy
J Neurol Neurosurg Psychiatry 84:35-41. 2013..To apply voxel-based methods to map the regional distribution of atrophy and T2 hyperintense lesions in the cervical cord of multiple sclerosis (MS) patients with different clinical phenotypes... - Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative studyMassimo Filippi
Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Radiology 262:932-40. 2012.... 
Predictive value of MRI findings in multiple sclerosisMassimo Filippi
Department of Neuroscience, Scientific Institute and University San Raffaele, Milan, Italy
Lancet Neurol 1:9. 2002- Magnetization transfer MRI in multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
J Neuroimaging 17:22S-26S. 2007.... - The use of quantitative magnetic-resonance-based techniques to monitor the evolution of multiple sclerosisMassimo Filippi
Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Lancet Neurol 2:337-46. 2003..These techniques are substantially changing our understanding of how MS causes irreversible disability and should be used more extensively in clinical trials and in studies of disease progression... - Occult tissue damage in patients with primary progressive multiple sclerosis is independent of T2-visible lesions--a diffusion tensor MR studyMaria A Rocca
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
J Neurol 250:456-60. 2003..This suggests that Wallerian degeneration of fibers passing through macroscopic abnormalities is not a major factor contributing to diffuse NABT pathology of these patients... - Magnetic resonance techniques to quantify tissue damage, tissue repair, and functional cortical reorganization in multiple sclerosisM Filippi
Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Prog Brain Res 175:465-82. 2009.... - MRI-clinical correlations in the primary progressive course of MS: new insights into the disease pathophysiology from the application of magnetization transfer, diffusion tensor, and functional MRIMassimo Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
J Neurol Sci 206:157-64. 2003.... - Magnetic resonance imaging of multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
J Neuroimaging 12:289-301. 2002.... - In-vivo tissue characterization of multiple sclerosis and other white matter diseases using magnetic resonance based techniquesM Filippi
Department of Neuroscience, Scientific Institute and University Ospedale, San Raffaele, Milan, Italy
J Neurol 248:1019-29. 2001.... - EFNS guidelines on the use of neuroimaging in the management of multiple sclerosisM Filippi
Neuroimaging Research Unit, Department of Neurology Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Eur J Neurol 13:313-25. 2006..In addition, they should provide a foundation for the development of more widespread but rational clinical applications of non-conventional MR-based techniques in studies of MS patients... - Functional MR imaging in multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute and University, Via Olgettina, 60 20132, Milan, Italy
Neuroimaging Clin N Am 19:59-70. 2009.... - Headache and migraineMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Neurol Sci 29:336-8. 2008..More recently, it has been suggested that the different forms of headache/migraine might have specific functional and structural MRI correlates, which, in the future, is likely to result in new therapeutic scenarios... - Conventional MRI in multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
J Neuroimaging 17:3S-9S. 2007.... - MRI evidence for multiple sclerosis as a diffuse disease of the central nervous systemMassimo Filippi
Neuroimaging Research Unit, Dept of Neurology Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
J Neurol 252:v16-24. 2005..This is central for identifying novel and effective treatment strategies... - Magnetic resonance techniques for the in vivo assessment of multiple sclerosis pathology: consensus report of the white matter study groupMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
J Magn Reson Imaging 21:669-75. 2005..Both of these steps are central to the design of future treatment strategies aimed at limiting the functional consequences of the most disabling aspects of this disease... - Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled studyMassimo Filippi
Neuroimaging Research Unit, Institute of Experimental Neurology and University Ospedale San Raffaele, Milan, Italy
Lancet Neurol 5:213-20. 2006..This study assessed whether two doses of glatiramer acetate given orally could improve clinical and MRI measures of inflammation and neurodegeneration in a large cohort of patients with relapsing-remitting multiple sclerosis... - MR imaging of Devic's neuromyelitis opticaM Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele Milan, Italy
Neurol Sci 25:S371-3. 2004.... - Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trialMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Lancet 364:1489-96. 2004..We aimed to assess whether this drug can also reduce the rate of brain volume decrease in such patients enrolled in the ETOMS (early treatment of multiple sclerosis) trial... - Imaging primary progressive multiple sclerosis: the contribution of structural, metabolic, and functional MRI techniquesMassimo Filippi
Department of Neurology, Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Mult Scler 10:S36-44; discussion S44-5. 2004.... - Multiple sclerosis and allied white matter diseasesMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Neurol Sci 29:319-22. 2008..Future improvements, including the development of new sequences and post-processing methods as well as the use of high-field MRI, despite being a major technical challenge, hold new and exciting promise... - MRI techniques to monitor MS evolution: the present and the futureMassimo Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 58:1147-53. 2002.... - Clinical trials and clinical practice in multiple sclerosis: conventional and emerging magnetic resonance imaging technologiesMassimo Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Curr Neurol Neurosci Rep 2:267-76. 2002.... - Linking structural, metabolic and functional changes in multiple sclerosisM Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Eur J Neurol 8:291-7. 2001..The present review summarizes how the application of these MR techniques to the study of MS is dramatically changing our understanding of how MS causes irreversible neurological deficits... 
The brain functional networks associated to human and animal suffering differ among omnivores, vegetarians and vegansMassimo Filippi
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
PLoS ONE 5:e10847. 2010..These results suggest that empathy toward non conspecifics has different neural representation among individuals with different feeding habits, perhaps reflecting different motivational factors and beliefs...- Magnetization transfer and diffusion tensor MR imaging of basal ganglia from patients with multiple sclerosisM Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
J Neurol Sci 183:69-72. 2001..These data suggest that the more sophisticated MR probes of tissue disruption and cellular integrity are no more sensitive than current conventional imaging for detecting basal ganglia abnormalities in patients with MS... - Intracortical lesions: relevance for new MRI diagnostic criteria for multiple sclerosisM Filippi
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Neurology 75:1988-94. 2010..To generate and validate new MRI diagnostic criteria for multiple sclerosis (MS) taking into account not only white matter lesions but also intracortical lesions (ICLs)... - [Magnetic resonance imaging correlates of cognitive dysfunction in patients with multiple sclerosis]M Filippi
Departamento de Neurociencias, Istituto Scientifico Ospedale San Raffaele, Milan, Italia
Rev Neurol 30:1253-6. 2000.... - Interferon β-1b and glatiramer acetate effects on permanent black hole evolutionM Filippi
University Hospital San Raffaele, Via Olgettina, 20132 Milan, Italy
Neurology 76:1222-8. 2011.... - In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosisM Rovaris
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Brain 124:2540-9. 2001..They also suggest that the severity of multiple sclerosis pathology in the cervical cord is one of the factors contributing to neurological impairment in PP multiple sclerosis... - A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imagingM Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Arch Neurol 57:1017-21. 2000.... - A longitudinal study comparing the sensitivity of CSE and RARE sequences in detecting new multiple sclerosis lesionsM Filippi
Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
Magn Reson Imaging 17:457-8. 1999..Thirty-five lesions were seen on both sequences, three only on CSE and six only on FSE. This study indicates that CSE may be substituted by RARE when monitoring short-term disease activity in MS... - Irreversible disability and tissue loss in multiple sclerosis: a conventional and magnetization transfer magnetic resonance imaging study of the optic nervesMatilde Inglese
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Arch Neurol 59:250-5. 2002.... - A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosisAntonia Ceccarelli
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 30:3009-19. 2009..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology... - Structural and functional MRI correlates of Stroop control in benign MSMaria A Rocca
Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 30:276-90. 2009.... - Corpus callosum damage and cognitive dysfunction in benign MSSarlota Mesaros
Scientific Institute, University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 30:2656-66. 2009..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS... - Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypesMaria A Rocca
Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
Lancet Neurol 4:618-26. 2005..Then bilateral activation of these regions is seen, and late in the disease course, areas that healthy people recruit to do novel or complex tasks are activated... - Pyramidal tract lesions and movement-associated cortical recruitment in patients with MSMaria A Rocca
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neuroimage 23:141-7. 2004..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits... - Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance studyAnnalisa Pulizzi
Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
Arch Neurol 64:1163-8. 2007.... - The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI studyAntonia Ceccarelli
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neuroimage 39:1499-509. 2008..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status... - A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosisAntonio Gallo
Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
J Neurol 254:78-83. 2007..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution... - Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosisMaria A Rocca
Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neuroimage 18:847-55. 2003..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage... - fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injectionMaria A Rocca
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 28:373-82. 2007..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients... - Brain macro- and microscopic damage in patients with paediatric MSMartina Absinta
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
J Neurol Neurosurg Psychiatry 81:1357-62. 2010.... - Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging studyCelia Oreja-Guevara
Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
Arch Neurol 62:578-84. 2005..Such changes do not reflect a concomitant development of brain atrophy and confirm the importance of GM pathology in MS... - Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?Maria A Rocca
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 30:2844-51. 2009.... - A three-year, multi-parametric MRI study in patients at presentation with CISMaria A Rocca
Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale, San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
J Neurol 255:683-91. 2008..To define the extent of overall brain damage in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to identify non-conventional magnetic resonance (MR) metrics predictive of evolution to definite MS... - Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosisMaria A Rocca
Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Radiology 254:541-50. 2010.... - Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imagingMaria A Rocca
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Stroke 34:665-70. 2003..80, P<0.001). CONCLUSIONS: This study suggests that functional cortical changes occur in patients with migraine and brain MRI abnormalities and that they might be secondary to the extent of subcortical structural damage... - Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosisAntonio Gallo
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Arch Neurol 62:803-8. 2005.... - Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre studyMarco Rovaris
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
Mult Scler 17:319-26. 2011..We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course... - Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI studyMaria Assunta Rocca
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
J Neurol 256:470-82. 2009.... - Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's diseaseFederica Agosta
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
Hum Brain Mapp 31:515-25. 2010.... - Thalamic damage and long-term progression of disability in multiple sclerosisMaria Assunta Rocca
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Radiology 257:463-9. 2010.... - MRI predictors of long-term evolution in amyotrophic lateral sclerosisFederica Agosta
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Eur J Neurosci 32:1490-6. 2010..56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity... - Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotypeGianna Riccitelli
Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 32:1535-43. 2011..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype... - Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosisMarco Rovaris
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Arch Neurol 62:898-902. 2005.... - A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosisSarlota Mesaros
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Arch Neurol 65:1223-30. 2008..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity... - Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR studyPaolo Preziosa
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
Radiology 260:541-50. 2011.... - Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosisAntonia Ceccarelli
Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Eur J Neurosci 31:1273-80. 2010..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions... - Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up studySarlota Mesaros
Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
J Neurol 255:1378-83. 2008..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease... - Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degenerationMassimo Filippi
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Neuroimage 18:558-63. 2003..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex... - Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brainMaria A Rocca
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
Neuroimage 19:826-36. 2003.... - Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosisAntonia Ceccarelli
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
Mult Scler 17:702-7. 2011.... - Primary progressive multiple sclerosis: tactile-associated functional MR activity in the cervical spinal cordFederica Agosta
Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, 20132 Milan, Italy
Radiology 253:209-15. 2009.... - Assessment of brain white matter fiber bundle atrophy in patients with Friedreich ataxiaElisabetta Pagani
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Radiology 255:882-9. 2010.... - A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-upElisa Scola
Neuroradiology Unit and CERMAC, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
J Neurol Neurosurg Psychiatry 81:798-805. 2010.... - Evidence for cervical cord tissue disorganisation with aging by diffusion tensor MRIFederica Agosta
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neuroimage 36:728-35. 2007..22, p=0.04) as independent correlates of age (r2=0.76). Cervical cord is vulnerable to aging. The decrease of FA, in the absence of atrophy and MD changes, suggests gliosis as the most likely pathological feature of the aging cord... - Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up studyMarco Rovaris
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Brain 126:2323-32. 2003.... - In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosisB Benedetti
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Mult Scler 15:789-94. 2009.... - Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary studyM Codella
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
J Neurol Sci 194:71-4. 2002..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS... - Bimonthly assessment of magnetization transfer magnetic resonance imaging parameters in multiple sclerosis: a 14-month, multicentre, follow-up studyS Mesaros
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, 20132 Milan Italy
Mult Scler 16:325-31. 2010..The steady correlation observed between conventional and MT MRI measures over time supports the hypothesis of axonal degeneration of fibres passing through focal lesions as one of the factors contributing to the overall MS burden... - Secondary progressive multiple sclerosis: current knowledge and future challengesMarco Rovaris
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Lancet Neurol 5:343-54. 2006.... - A composite score to predict short-term disease activity in patients with relapsing-remitting MSMaria Pia Sormani
Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
Neurology 69:1230-5. 2007..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term... - Assessing atrophy of the major white matter fiber bundles of the brain from diffusion tensor MRI dataElisabetta Pagani
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Magn Reson Med 58:527-34. 2007..The effectiveness of the method was then tested on data from five patients with multiple sclerosis (MS) and two patients with amyotrophic lateral sclerosis (ALS)... - A reassessment of the plateauing relationship between T2 lesion load and disability in MSMaria Pia Sormani
Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
Neurology 73:1538-42. 2009.... - The use of modern magnetic resonance techniques to monitor disease evolution in multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Adv Neurol 98:167-83. 2006 - Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolutionM Rovaris
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 65:1626-30. 2005.... - Evidence of thalamic gray matter loss in pediatric multiple sclerosisS Mesaros
Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Neurology 70:1107-12. 2008.... - In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI studyF Agosta
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Brain 130:2211-9. 2007..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual... - An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MSM Rovaris
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Neurology 63:584-5. 2004..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS... - Default-mode network dysfunction and cognitive impairment in progressive MSM A Rocca
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 74:1252-9. 2010.... - The "mirror-neuron system" in MS: A 3 tesla fMRI studyM A Rocca
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Neurology 70:255-62. 2008..We used functional MRI (fMRI) to investigate the properties of the MNS in patients with multiple sclerosis (MS)... - The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MSM Inglese
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 60:853-60. 2003.... - Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 yearsM Rovaris
Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
Brain 129:2628-34. 2006..These data may be relevant to select patients for future exploratory phase II trials... - Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRIF Agosta
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 64:631-5. 2005..Such cord diffusivity changes in patients with PPMS are likely to reflect irreversible axonal injury and reactive gliosis and seem to be independent of brain damage... - Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRIB Benedetti
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 67:161-3. 2006..008) and average fractional anisotropy (p = 0.04). There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity (r = 0.52, p = 0.02)... - Measurement error of two different techniques for brain atrophy assessment in multiple sclerosisM P Sormani
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 62:1432-4. 2004..As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients... - Long-term follow-up of patients treated with glatiramer acetate: a multicentre, multinational extension of the European/Canadian double-blind, placebo-controlled, MRI-monitored trialM Rovaris
Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
Mult Scler 13:502-8. 2007..An earlier initiation of GA treatment in patients with active RRMS might, at least partially, have a favourable impact on long-term disease evolution... - MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosisP Tortorella
Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
J Neurol 253:903-7. 2006..It also suggests that in these patients GM is spared by the disease process and that NAWM changes are likely to be secondary to Wallerian degeneration of fibers passing through macroscopic lesions... - MRI features of benign multiple sclerosis: toward a new definition of this disease phenotypeM Rovaris
Multiple Sclerosis Centre, Scientific Institute Santa Maria Nascente, Fondazione Don Gnocchi, Milan, Italy
Neurology 72:1693-701. 2009..In addition, the results of correlative MRI/neuropsychology studies underpin the need for a new definition of BMS, which should consider the maintenance of a normal cognitive profile as an additional criterion... - Novel MRI approaches to assess patients with multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
Curr Opin Neurol 23:212-7. 2010..This review summarizes novel MRI approaches for the investigation of lesion burden and understanding of the pathophysiology of multiple sclerosis (MS)... - Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosisMarco Rovaris
Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
Mult Scler 14:455-64. 2008..Sequence-related variability of measurements makes the standardization of MT MRI acquisition essential for the design of multicentre studies... - Disturbed function and plasticity in multiple sclerosis as gleaned from functional magnetic resonance imagingMassimo Filippi
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy
Curr Opin Neurol 16:275-82. 2003.... - European study on intravenous immunoglobulin in multiple sclerosis: results of magnetization transfer magnetic resonance imaging analysisMassimo Filippi
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
Arch Neurol 61:1409-12. 2004..Magnetization transfer magnetic resonance imaging (MT MRI) can provide in vivo markers reflecting the severity of multiple sclerosis-related brain damage occurring within and outside T2-visible lesions... - Simple and complex movement-associated functional MRI changes in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosisMassimo Filippi
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Hum Brain Mapp 21:108-17. 2004..Local synaptic reorganization, recruitment of parallel existing pathways, and reorganization of distant sites are all likely to contribute to the observed functional changes. Hum. Brain Mapping 21:106-115, 2004... - Interventions for the prevention of brain atrophy in multiple sclerosis : current statusMarco Rovaris
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
CNS Drugs 17:563-75. 2003.... - Effects of glatiramer acetate on relapse rate and accumulated disability in multiple sclerosis: meta-analysis of three double-blind, randomized, placebo-controlled clinical trialsFilippo Martinelli Boneschi
Department of Neuroscience, Scientific Institute, University H San Raffaele, Milan, Italy
Mult Scler 9:349-55. 2003..It also suggests that GA efficacy is not significantly influenced by the patients' clinical characteristics at the time of treatment initiation... - Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry studyMassimo Filippi
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
PLoS ONE 5:e10198. 2010..The scheme applied during the learning phase influences the pattern of such structural changes... - Can glatiramer acetate reduce brain atrophy development in multiple sclerosis?Marco Rovaris
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60 20132 Milan, Italy
J Neurol Sci 233:139-43. 2005..Further studies of adequate duration are now required to address this issue, as well as to confirm the sustained efficacy of GA treatment over long periods of follow-up...