Massimo Filippi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. doi request reprint Insights from magnetic resonance imaging
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Electronic address
    Handb Clin Neurol 122:115-49. 2014
  2. doi request reprint Functional network connectivity in the behavioral variant of frontotemporal dementia
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Electronic address
    Cortex 49:2389-401. 2013
  3. doi request reprint Assessment of system dysfunction in the brain through MRI-based connectomics
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Vita Salute San Raffaele University, Milan, Italy Department of Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Electronic address
    Lancet Neurol 12:1189-99. 2013
  4. pmc Variability in detection and quantification of interferon β-1b-induced neutralizing antibodies
    Hans Peter Hartung
    Heinrich Heine Universitat, Moorenstraße 5, Dusseldorf 40225, Germany
    J Neuroinflammation 9:129. 2012
  5. doi request reprint The "vegetarian brain": chatting with monkeys and pigs?
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
    Brain Struct Funct 218:1211-27. 2013
  6. doi request reprint Imaging cortical damage and dysfunction in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    JAMA Neurol 70:556-64. 2013
  7. doi request reprint Vitamin A: yet another player in multiple sclerosis pathogenesis?
    Massimo Filippi
    Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
    Expert Rev Clin Immunol 9:113-5. 2013
  8. doi request reprint Voxel-wise mapping of cervical cord damage in multiple sclerosis patients with different clinical phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60 20132 Milan, Italy
    J Neurol Neurosurg Psychiatry 84:35-41. 2013
  9. doi request reprint Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
  10. ncbi request reprint Predictive value of MRI findings in multiple sclerosis
    Massimo Filippi
    Department of Neuroscience, Scientific Institute and University San Raffaele, Milan, Italy
    Lancet Neurol 1:9. 2002

Detail Information

Publications165 found, 100 shown here

  1. doi request reprint Insights from magnetic resonance imaging
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Electronic address
    Handb Clin Neurol 122:115-49. 2014
    ..All conventional and nonconventional MR techniques will benefit from the use of high-field MR systems (3.0T or more). ..
  2. doi request reprint Functional network connectivity in the behavioral variant of frontotemporal dementia
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Electronic address
    Cortex 49:2389-401. 2013
    ....
  3. doi request reprint Assessment of system dysfunction in the brain through MRI-based connectomics
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Vita Salute San Raffaele University, Milan, Italy Department of Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Electronic address
    Lancet Neurol 12:1189-99. 2013
    ..Future network-based research might enable indentification of different stages of disorders, subtypes for cognitive impairment, and connectivity profiles associated with different clinical outcomes. ..
  4. pmc Variability in detection and quantification of interferon β-1b-induced neutralizing antibodies
    Hans Peter Hartung
    Heinrich Heine Universitat, Moorenstraße 5, Dusseldorf 40225, Germany
    J Neuroinflammation 9:129. 2012
    ..Interferon-beta (IFNB) therapy for multiple sclerosis can lead to the induction of neutralizing antibodies (NAbs) against IFNB. Various methods are used for detection and quantification of NAbs...
  5. doi request reprint The "vegetarian brain": chatting with monkeys and pigs?
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
    Brain Struct Funct 218:1211-27. 2013
    ..These results support the role of the action observation-execution matching system in social cognition, which enables us to interact not only with our conspecifics but also with species in phylogenetic proximity to humans. ..
  6. doi request reprint Imaging cortical damage and dysfunction in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    JAMA Neurol 70:556-64. 2013
    ..This review summarizes the main findings from studies using both conventional and modern quantitative magnetic resonance-based techniques for the assessment of cortical damage and dysfunction in patients with multiple sclerosis...
  7. doi request reprint Vitamin A: yet another player in multiple sclerosis pathogenesis?
    Massimo Filippi
    Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
    Expert Rev Clin Immunol 9:113-5. 2013
    ..Following IFN-β-1a treatment, the association with MRI metrics was lost. These results support a role of vitamin A metabolites in influencing disease activity in MS...
  8. doi request reprint Voxel-wise mapping of cervical cord damage in multiple sclerosis patients with different clinical phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60 20132 Milan, Italy
    J Neurol Neurosurg Psychiatry 84:35-41. 2013
    ..To apply voxel-based methods to map the regional distribution of atrophy and T2 hyperintense lesions in the cervical cord of multiple sclerosis (MS) patients with different clinical phenotypes...
  9. doi request reprint Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
    ....
  10. ncbi request reprint Predictive value of MRI findings in multiple sclerosis
    Massimo Filippi
    Department of Neuroscience, Scientific Institute and University San Raffaele, Milan, Italy
    Lancet Neurol 1:9. 2002
  11. doi request reprint Functional MR imaging in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute and University, Via Olgettina, 60 20132, Milan, Italy
    Neuroimaging Clin N Am 19:59-70. 2009
    ....
  12. ncbi request reprint The use of quantitative magnetic-resonance-based techniques to monitor the evolution of multiple sclerosis
    Massimo Filippi
    Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 2:337-46. 2003
    ..These techniques are substantially changing our understanding of how MS causes irreversible disability and should be used more extensively in clinical trials and in studies of disease progression...
  13. ncbi request reprint MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system
    Massimo Filippi
    Neuroimaging Research Unit, Dept of Neurology Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 252:v16-24. 2005
    ..This is central for identifying novel and effective treatment strategies...
  14. ncbi request reprint Occult tissue damage in patients with primary progressive multiple sclerosis is independent of T2-visible lesions--a diffusion tensor MR study
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 250:456-60. 2003
    ..This suggests that Wallerian degeneration of fibers passing through macroscopic abnormalities is not a major factor contributing to diffuse NABT pathology of these patients...
  15. doi request reprint Magnetic resonance techniques to quantify tissue damage, tissue repair, and functional cortical reorganization in multiple sclerosis
    M Filippi
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Prog Brain Res 175:465-82. 2009
    ....
  16. pmc The brain functional networks associated to human and animal suffering differ among omnivores, vegetarians and vegans
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    PLoS ONE 5:e10847. 2010
    ..These results suggest that empathy toward non conspecifics has different neural representation among individuals with different feeding habits, perhaps reflecting different motivational factors and beliefs...
  17. doi request reprint Headache and migraine
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurol Sci 29:336-8. 2008
    ..More recently, it has been suggested that the different forms of headache/migraine might have specific functional and structural MRI correlates, which, in the future, is likely to result in new therapeutic scenarios...
  18. doi request reprint Multiple sclerosis and allied white matter diseases
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurol Sci 29:319-22. 2008
    ..Future improvements, including the development of new sequences and post-processing methods as well as the use of high-field MRI, despite being a major technical challenge, hold new and exciting promise...
  19. ncbi request reprint Magnetic resonance techniques for the in vivo assessment of multiple sclerosis pathology: consensus report of the white matter study group
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Magn Reson Imaging 21:669-75. 2005
    ..Both of these steps are central to the design of future treatment strategies aimed at limiting the functional consequences of the most disabling aspects of this disease...
  20. ncbi request reprint Magnetization transfer MRI in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Neuroimaging 17:22S-26S. 2007
    ....
  21. ncbi request reprint Conventional MRI in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Neuroimaging 17:3S-9S. 2007
    ....
  22. ncbi request reprint Imaging primary progressive multiple sclerosis: the contribution of structural, metabolic, and functional MRI techniques
    Massimo Filippi
    Department of Neurology, Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Mult Scler 10:S36-44; discussion S44-5. 2004
    ....
  23. ncbi request reprint EFNS guidelines on the use of neuroimaging in the management of multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neurology Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Eur J Neurol 13:313-25. 2006
    ..In addition, they should provide a foundation for the development of more widespread but rational clinical applications of non-conventional MR-based techniques in studies of MS patients...
  24. ncbi request reprint Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet 364:1489-96. 2004
    ..We aimed to assess whether this drug can also reduce the rate of brain volume decrease in such patients enrolled in the ETOMS (early treatment of multiple sclerosis) trial...
  25. ncbi request reprint MR imaging of Devic's neuromyelitis optica
    M Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele Milan, Italy
    Neurol Sci 25:S371-3. 2004
    ....
  26. ncbi request reprint Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:213-20. 2006
    ..This study assessed whether two doses of glatiramer acetate given orally could improve clinical and MRI measures of inflammation and neurodegeneration in a large cohort of patients with relapsing-remitting multiple sclerosis...
  27. ncbi request reprint MRI-clinical correlations in the primary progressive course of MS: new insights into the disease pathophysiology from the application of magnetization transfer, diffusion tensor, and functional MRI
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol Sci 206:157-64. 2003
    ....
  28. pmc Interferon β-1b and glatiramer acetate effects on permanent black hole evolution
    M Filippi
    University Hospital San Raffaele, Via Olgettina, 20132 Milan, Italy
    Neurology 76:1222-8. 2011
    ....
  29. ncbi request reprint Linking structural, metabolic and functional changes in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Eur J Neurol 8:291-7. 2001
    ..The present review summarizes how the application of these MR techniques to the study of MS is dramatically changing our understanding of how MS causes irreversible neurological deficits...
  30. doi request reprint Intracortical lesions: relevance for new MRI diagnostic criteria for multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 75:1988-94. 2010
    ..To generate and validate new MRI diagnostic criteria for multiple sclerosis (MS) taking into account not only white matter lesions but also intracortical lesions (ICLs)...
  31. ncbi request reprint Magnetization transfer and diffusion tensor MR imaging of basal ganglia from patients with multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol Sci 183:69-72. 2001
    ..These data suggest that the more sophisticated MR probes of tissue disruption and cellular integrity are no more sensitive than current conventional imaging for detecting basal ganglia abnormalities in patients with MS...
  32. ncbi request reprint In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis
    M Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 124:2540-9. 2001
    ..They also suggest that the severity of multiple sclerosis pathology in the cervical cord is one of the factors contributing to neurological impairment in PP multiple sclerosis...
  33. ncbi request reprint [Magnetic resonance imaging correlates of cognitive dysfunction in patients with multiple sclerosis]
    M Filippi
    Departamento de Neurociencias, Istituto Scientifico Ospedale San Raffaele, Milan, Italia
    Rev Neurol 30:1253-6. 2000
    ....
  34. ncbi request reprint Irreversible disability and tissue loss in multiple sclerosis: a conventional and magnetization transfer magnetic resonance imaging study of the optic nerves
    Matilde Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 59:250-5. 2002
    ....
  35. ncbi request reprint A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Arch Neurol 57:1017-21. 2000
    ....
  36. ncbi request reprint A longitudinal study comparing the sensitivity of CSE and RARE sequences in detecting new multiple sclerosis lesions
    M Filippi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Magn Reson Imaging 17:457-8. 1999
    ..Thirty-five lesions were seen on both sequences, three only on CSE and six only on FSE. This study indicates that CSE may be substituted by RARE when monitoring short-term disease activity in MS...
  37. ncbi request reprint Clinical trials and clinical practice in multiple sclerosis: conventional and emerging magnetic resonance imaging technologies
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Curr Neurol Neurosci Rep 2:267-76. 2002
    ....
  38. ncbi request reprint MRI techniques to monitor MS evolution: the present and the future
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 58:1147-53. 2002
    ....
  39. ncbi request reprint Magnetic resonance imaging of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neuroimaging 12:289-301. 2002
    ....
  40. ncbi request reprint In-vivo tissue characterization of multiple sclerosis and other white matter diseases using magnetic resonance based techniques
    M Filippi
    Department of Neuroscience, Scientific Institute and University Ospedale, San Raffaele, Milan, Italy
    J Neurol 248:1019-29. 2001
    ....
  41. ncbi request reprint Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
    ....
  42. doi request reprint A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
    ..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology...
  43. ncbi request reprint Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Movement-associated cortical reorganisation is known to occur in multiple sclerosis (MS). We aimed to define the development of such cortical reorganisation by comparing data from patients with different disease phenotypes...
  44. doi request reprint Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
    ..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS...
  45. ncbi request reprint Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Maria A Rocca
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 18:847-55. 2003
    ..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage...
  46. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  47. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  48. ncbi request reprint The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
    ..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status...
  49. doi request reprint Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2844-51. 2009
    ....
  50. doi request reprint Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 31:515-25. 2010
    ....
  51. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  52. ncbi request reprint A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...
  53. doi request reprint Brain macro- and microscopic damage in patients with paediatric MS
    Martina Absinta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:1357-62. 2010
    ....
  54. ncbi request reprint Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues...
  55. doi request reprint A three-year, multi-parametric MRI study in patients at presentation with CIS
    Maria A Rocca
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale, San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    J Neurol 255:683-91. 2008
    ..To define the extent of overall brain damage in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to identify non-conventional magnetic resonance (MR) metrics predictive of evolution to definite MS...
  56. doi request reprint Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  57. doi request reprint Gray matter damage predicts the accumulation of disability 13 years later in MS
    Massimo Filippi
    From the Neuroimaging Research Unit M F, P P, G R, M A R, Institute of Experimental Neurology, and Department of Neurology M F, P P, V M, G C, M A R, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan Biostatistics Unit M C, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy and Medical Physics Group M A H, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, UK
    Neurology 81:1759-67. 2013
    ....
  58. doi request reprint A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up
    Elisa Scola
    Neuroradiology Unit and CERMAC, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol Neurosurg Psychiatry 81:798-805. 2010
    ....
  59. ncbi request reprint Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..We also investigated whether the extent of brain activations was correlated with WM structural pathology measured using diffusion tensor (DT) MRI...
  60. doi request reprint Thalamic damage and long-term progression of disability in multiple sclerosis
    Maria Assunta Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 257:463-9. 2010
    ....
  61. doi request reprint Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI study
    Maria Assunta Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 256:470-82. 2009
    ....
  62. doi request reprint MRI predictors of long-term evolution in amyotrophic lateral sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Eur J Neurosci 32:1490-6. 2010
    ..56. This study shows that more severe CST DT MRI abnormalities predict a poorer long-term clinical outcome in ALS patients. DT MRI of the brain has the potential to offer in vivo markers of disease severity...
  63. doi request reprint Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
    Gianna Riccitelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 32:1535-43. 2011
    ..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype...
  64. ncbi request reprint Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:898-902. 2005
    ..Proton magnetic resonance spectroscopy (1H-MRS) can be used to measure in vivo whole-brain N-acetylaspartate (WBNAA) concentrations, the decrease of whose levels is considered a marker of neuronal-axonal injury...
  65. doi request reprint Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre study
    Marco Rovaris
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Mult Scler 17:319-26. 2011
    ..We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course...
  66. ncbi request reprint Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:803-8. 2005
    ..Diffusion-tensor (DT) magnetic resonance imaging (MRI) has the potential to elucidate some characteristics of tissue microstructure inaccessible to other MRI techniques...
  67. doi request reprint A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 65:1223-30. 2008
    ..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity...
  68. doi request reprint Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study
    Paolo Preziosa
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Radiology 260:541-50. 2011
    ....
  69. doi request reprint Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
    Mult Scler 17:702-7. 2011
    ....
  70. doi request reprint Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Eur J Neurosci 31:1273-80. 2010
    ..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions...
  71. doi request reprint Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up study
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1378-83. 2008
    ..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease...
  72. ncbi request reprint Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
    ..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex...
  73. doi request reprint Primary progressive multiple sclerosis: tactile-associated functional MR activity in the cervical spinal cord
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, 20132 Milan, Italy
    Radiology 253:209-15. 2009
    ....
  74. ncbi request reprint Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  75. ncbi request reprint Evidence for cervical cord tissue disorganisation with aging by diffusion tensor MRI
    Federica Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 36:728-35. 2007
    ..22, p=0.04) as independent correlates of age (r2=0.76). Cervical cord is vulnerable to aging. The decrease of FA, in the absence of atrophy and MD changes, suggests gliosis as the most likely pathological feature of the aging cord...
  76. doi request reprint Assessment of brain white matter fiber bundle atrophy in patients with Friedreich ataxia
    Elisabetta Pagani
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 255:882-9. 2010
    ....
  77. ncbi request reprint Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:2323-32. 2003
    ....
  78. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  79. ncbi request reprint Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  80. doi request reprint Bimonthly assessment of magnetization transfer magnetic resonance imaging parameters in multiple sclerosis: a 14-month, multicentre, follow-up study
    S Mesaros
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, 20132 Milan Italy
    Mult Scler 16:325-31. 2010
    ..The steady correlation observed between conventional and MT MRI measures over time supports the hypothesis of axonal degeneration of fibres passing through focal lesions as one of the factors contributing to the overall MS burden...
  81. doi request reprint A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  82. ncbi request reprint Assessing atrophy of the major white matter fiber bundles of the brain from diffusion tensor MRI data
    Elisabetta Pagani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Magn Reson Med 58:527-34. 2007
    ..The effectiveness of the method was then tested on data from five patients with multiple sclerosis (MS) and two patients with amyotrophic lateral sclerosis (ALS)...
  83. ncbi request reprint Secondary progressive multiple sclerosis: current knowledge and future challenges
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:343-54. 2006
    ....
  84. ncbi request reprint The use of modern magnetic resonance techniques to monitor disease evolution in multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Adv Neurol 98:167-83. 2006
  85. ncbi request reprint A composite score to predict short-term disease activity in patients with relapsing-remitting MS
    Maria Pia Sormani
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Neurology 69:1230-5. 2007
    ..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term...
  86. doi request reprint Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  87. ncbi request reprint In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  88. ncbi request reprint The "mirror-neuron system" in MS: A 3 tesla fMRI study
    M A Rocca
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 70:255-62. 2008
    ..We used functional MRI (fMRI) to investigate the properties of the MNS in patients with multiple sclerosis (MS)...
  89. ncbi request reprint Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  90. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  91. doi request reprint Default-mode network dysfunction and cognitive impairment in progressive MS
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 74:1252-9. 2010
    ....
  92. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  93. ncbi request reprint The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    M Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 60:853-60. 2003
    ..Magnetization transfer (MT) MRI can provide in vivo markers reflecting the severity of irreversible, MS-related brain damage occurring within and outside T2-visible lesions...
  94. ncbi request reprint Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis
    M P Sormani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 62:1432-4. 2004
    ..As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients...
  95. ncbi request reprint Long-term follow-up of patients treated with glatiramer acetate: a multicentre, multinational extension of the European/Canadian double-blind, placebo-controlled, MRI-monitored trial
    M Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 13:502-8. 2007
    ..An earlier initiation of GA treatment in patients with active RRMS might, at least partially, have a favourable impact on long-term disease evolution...
  96. ncbi request reprint Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI
    F Agosta
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 64:631-5. 2005
    ..To investigate the extent and severity of cervical cord damage using diffusion tensor MRI (DT-MRI) and histogram analysis in patients with primary progressive MS (PPMS)...
  97. ncbi request reprint MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis
    P Tortorella
    Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol 253:903-7. 2006
    ..Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS...
  98. ncbi request reprint Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI
    B Benedetti
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 67:161-3. 2006
    ..008) and average fractional anisotropy (p = 0.04). There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity (r = 0.52, p = 0.02)...
  99. doi request reprint MRI features of benign multiple sclerosis: toward a new definition of this disease phenotype
    M Rovaris
    Multiple Sclerosis Centre, Scientific Institute Santa Maria Nascente, Fondazione Don Gnocchi, Milan, Italy
    Neurology 72:1693-701. 2009
    ..In addition, the results of correlative MRI/neuropsychology studies underpin the need for a new definition of BMS, which should consider the maintenance of a normal cognitive profile as an additional criterion...
  100. doi request reprint MR imaging of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 259:659-81. 2011
    ..The utility of these modern MR techniques in clinical trial monitoring and in the assessment of the individual patient's response to treatment still need to be evaluated...
  101. doi request reprint Phase III dose-comparison study of glatiramer acetate for multiple sclerosis
    Giancarlo Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Ann Neurol 69:75-82. 2011
    ..To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg compared to a 20mg dose...