Luigi Ferini-Strambi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Epidemiology of obstructive sleep apnea syndrome
    L Ferini-Strambi
    Department of Neurology, Sleep Disorders Center, Vita Salute University, San Raffaele Hospital, Via Stamira d Ancona 20, 20127 Milan, Italy
    Minerva Med 95:187-202. 2004
  2. doi Sleep dysfunction in multiple system atrophy
    Luigi Ferini-Strambi
    Department of Clinical Neurosciences, Sleep Disorders Center, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127, Milan, Italy
    Curr Treat Options Neurol 14:464-73. 2012
  3. ncbi Does the Type of Multisystem Atrophy, Parkinsonism, or Cerebellar Ataxia Impact on the Nature of Sleep Disorders?
    Luigi Ferini-Strambi
    Department of Clinical Neurosciences, San Raffaele Scientific Institute, Sleep Disorders Center, Universita Vita Salute San Raffaele, Milan, Italy
    Curr Neurol Neurosci Rep 16:105. 2016
  4. ncbi Restless legs syndrome augmentation and pramipexole treatment
    L Ferini-Strambi
    Sleep Disorders Center, Universita Vita Salute, IRCCS H San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Sleep Med 3:S23-5. 2002
  5. doi The effects of Transcranial Direct Current Stimulation (tDCS) on Idiopathic Hypersomnia: a pilot study
    Andrea Galbiati
    Department of Clinical Neurosciences, Neurology Sleep Disorders Center, University San Raffaele and Scientific Institute San Raffaele, Milan, 20132 Milan, Italy Email
    Arch Ital Biol 154:1-5. 2016
  6. doi REM sleep Behaviour Disorder
    Luigi Ferini-Strambi
    Department of Clinical Neurosciences, Neurology Sleep Disorder Center, San Raffaele Scientific Institute, 20127, Milan, Italy Vita Salute San Raffaele University, Faculty of Psychology, Milan, Italy Electronic address
    Parkinsonism Relat Disord 22:S69-72. 2016
  7. doi REM Sleep Behavior Disorder (RBD) as a marker of neurodegenerative disorders
    L Ferini-Strambi
    Sleep Disorders Center, Division of Neuroscience, Università Vita Salute San Raffaele, Milan, Italy
    Arch Ital Biol 152:129-46. 2014
  8. pmc The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular disease
    Luigi Ferini-Strambi
    Sleep Disorders Center, Vita Salute San Raffaele University, Milan, Italy
    J Neurol 261:1051-68. 2014
  9. doi Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study
    Luigi Ferini-Strambi
    Department of Clinical Neuroscience, Sleep Disorders Center, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127, Milan, Italy
    J Neurol 261:1112-8. 2014
  10. doi Pharmacotherapy for restless legs syndrome
    Luigi Ferini-Strambi
    Ospedale San Raffaele and Università Vita Salute San Raffaele, Sleep Disorders Center, Division of Neuroscience, Via Stamira d Ancona 20, 20127 Milan, Italy 39 02 26433363 39 02 26433394
    Expert Opin Pharmacother 15:1127-38. 2014

Detail Information

Publications98

  1. ncbi Epidemiology of obstructive sleep apnea syndrome
    L Ferini-Strambi
    Department of Neurology, Sleep Disorders Center, Vita Salute University, San Raffaele Hospital, Via Stamira d Ancona 20, 20127 Milan, Italy
    Minerva Med 95:187-202. 2004
    ....
  2. doi Sleep dysfunction in multiple system atrophy
    Luigi Ferini-Strambi
    Department of Clinical Neurosciences, Sleep Disorders Center, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127, Milan, Italy
    Curr Treat Options Neurol 14:464-73. 2012
    ..CPAP is an effective treatment for eliminating obstructive sleep apnea in MSA patients, even if the adaptation to the device may be difficult in advanced cases...
  3. ncbi Does the Type of Multisystem Atrophy, Parkinsonism, or Cerebellar Ataxia Impact on the Nature of Sleep Disorders?
    Luigi Ferini-Strambi
    Department of Clinical Neurosciences, San Raffaele Scientific Institute, Sleep Disorders Center, Universita Vita Salute San Raffaele, Milan, Italy
    Curr Neurol Neurosci Rep 16:105. 2016
    ..These findings suggest that although the dominant clinical presentations differ between MSA-C and MSA-P, a common pathophysiology may underlie both subtypes of MSA...
  4. ncbi Restless legs syndrome augmentation and pramipexole treatment
    L Ferini-Strambi
    Sleep Disorders Center, Universita Vita Salute, IRCCS H San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Sleep Med 3:S23-5. 2002
    ..To evaluate in an open-label clinical series the occurrence of restless legs syndrome (RLS) augmentation in 60 consecutive RLS patients treated with pramipexole (PPX) for at least 6 months...
  5. doi The effects of Transcranial Direct Current Stimulation (tDCS) on Idiopathic Hypersomnia: a pilot study
    Andrea Galbiati
    Department of Clinical Neurosciences, Neurology Sleep Disorders Center, University San Raffaele and Scientific Institute San Raffaele, Milan, 20132 Milan, Italy Email
    Arch Ital Biol 154:1-5. 2016
    ..Our results indicate that tDCS may foster the management of EDS in IH, improving also the attentional domain. ..
  6. doi REM sleep Behaviour Disorder
    Luigi Ferini-Strambi
    Department of Clinical Neurosciences, Neurology Sleep Disorder Center, San Raffaele Scientific Institute, 20127, Milan, Italy Vita Salute San Raffaele University, Faculty of Psychology, Milan, Italy Electronic address
    Parkinsonism Relat Disord 22:S69-72. 2016
    ....
  7. doi REM Sleep Behavior Disorder (RBD) as a marker of neurodegenerative disorders
    L Ferini-Strambi
    Sleep Disorders Center, Division of Neuroscience, Università Vita Salute San Raffaele, Milan, Italy
    Arch Ital Biol 152:129-46. 2014
    ..Some prospective results in iRBD showed that potential markers of neurodegeneration are the following: 1) marked EEG slowing on spectral analysis; 2) decreased striatal 123I-FPCIT; 3) impaired color vision...
  8. pmc The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular disease
    Luigi Ferini-Strambi
    Sleep Disorders Center, Vita Salute San Raffaele University, Milan, Italy
    J Neurol 261:1051-68. 2014
    ..Understanding the relationships between RLS and hypertension, CVD, and stroke has important implications for reducing the risks associated with these diseases. ..
  9. doi Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study
    Luigi Ferini-Strambi
    Department of Clinical Neuroscience, Sleep Disorders Center, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127, Milan, Italy
    J Neurol 261:1112-8. 2014
    ..Our findings underline the importance of collecting data on autonomic symptoms in iRBD. These data may be used in prospective studies for evaluating the risk of developing neurodegenerative disorders. ..
  10. doi Pharmacotherapy for restless legs syndrome
    Luigi Ferini-Strambi
    Ospedale San Raffaele and Università Vita Salute San Raffaele, Sleep Disorders Center, Division of Neuroscience, Via Stamira d Ancona 20, 20127 Milan, Italy 39 02 26433363 39 02 26433394
    Expert Opin Pharmacother 15:1127-38. 2014
    ..Predominantly, symptoms occur at rest in the evening or at night, and they are alleviated by moving the affected extremity. RLS prevalence in the general population has been estimated to be approximately 5%...
  11. doi Effects of continuous positive airway pressure on cognitition and neuroimaging data in sleep apnea
    L Ferini-Strambi
    Sleep Disorders Center, Division of Neuroscience and Università Vita Salute San Raffaele, Milan, Italy Electronic address
    Int J Psychophysiol 89:203-12. 2013
    ..The purpose of this article is to provide a narrative review of the publications on cognition and neuroimaging in OSA before and after CPAP treatment. ..
  12. doi Nocturnal frontal lobe epilepsy and the acetylcholine receptor
    Luigi Ferini-Strambi
    Department of Neuroscience, Sleep Disorders Center, Universita Vita Salute San Raffaele, Milan, Italy
    Neurologist 18:343-9. 2012
    ..The genetic bases of the disease have been detected in a minority of cases. Mutations causing a gain of function of the neuronal nicotinic acetylcholine receptors were reported in 3 different subunits...
  13. doi Bruxism and nocturnal groaning
    L Ferini-Strambi
    Universita Vita Salute San Raffaele, Milan, Italy
    Arch Ital Biol 149:467-77. 2011
    ..Further studies should clarify the pathophysiology of SB and NG, especially when the two phenomena are associated...
  14. ncbi REM sleep behaviour disorder
    L Ferini-Strambi
    Sleep Disorders Center, Department of Neurology, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, I 20127 Milan, Italy
    Neurol Sci 26:s186-92. 2005
    ..The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies...
  15. ncbi Effects of reboxetine on sleep and nocturnal cardiac autonomic activity in patients with dysthymia
    Luigi Ferini-Strambi
    Sleep Disorders Center, Universita Vita Salute, IRCCS H San Raffaele, Italy
    J Psychopharmacol 18:417-22. 2004
    ..Long-term treatment with 4 mg reboxetine does not cause significant changes in cardiac autonomic function...
  16. ncbi Cerebrovascular diseases and sleep-disordered breathing
    Luigi Ferini-Strambi
    Dept of Neurology, Sleep Disorders Center, Universita Vita Salute San Raffaele, Milan, Italy
    Clin Exp Hypertens 28:225-31. 2006
    ..Specific treatment of SDB may reduce the possibility of further cerebrovascular disturbances...
  17. doi Treatment of restless legs syndrome
    Luigi Ferini-Strambi
    Sleep Disorders Center, Department of Neuroscience, Universita Vita Salute San Raffaele, Milan, Italy
    Parkinsonism Relat Disord 15:S65-70. 2009
    ..Pharmacological treatment should be limited to those patients who suffer from clinically relevant RLS with impaired sleep quality or quality of life. Treatment on demand is a clinical need in RLS cases that present intermittent symptoms...
  18. ncbi Treatment options for restless legs syndrome
    Luigi Ferini-Strambi
    Universita Vita Salute San Raffaele, Sleep Disorders Center, Milan, Italy
    Expert Opin Pharmacother 10:545-54. 2009
    ..Dopaminergic agents are the best-studied agents, and are considered first-line treatment of RLS...
  19. ncbi Increased periodic arousal fluctuations during non-REM sleep are associated to superior memory
    Luigi Ferini-Strambi
    Sleep Disorders Center, Scientific Institute H San Raffaele, University Vita Salute San Raffaele, Via Stamina d Ancona 20, 20127 Milano, Italy
    Brain Res Bull 63:439-42. 2004
    ..D. units above that observed in age-matched controls). Since CAP rate reflects the structural organization of non-REM sleep, this observation supports the hypothesis of a link between non-REM sleep and declarative memory performance...
  20. ncbi RLS-like symptoms: differential diagnosis by history and clinical assessment
    Luigi Ferini-Strambi
    Sleep Disorders Center, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Sleep Med 8:S3-6. 2007
    ....
  21. ncbi Genetics in restless legs syndrome
    Luigi Ferini-Strambi
    Sleep Disorders Center, University Vita Salute San Raffaele and Human Molecular Genetics Unit, Dibit San Raffaele Hospital, Via Stamina d Ancona 20, 20122 Milano, Italy
    Sleep Med 5:301-4. 2004
    ..However, the efforts toward the identification of RLS genes must continue in order to obtain a better characterization of the syndrome and to identify new therapeutic strategies...
  22. ncbi Snoring & sleep apnea: a population study in Italian women
    L Ferini-Strambi
    Sleep Disorders Center, State University and IRCCS H San Raffaele, Milan, Italy
    Sleep 22:859-64. 1999
    ..We concluded that in middle-aged women, both snoring and sleep apnea are very common. A high percentage of snoring is not essential for the occurrence of sleep apnea, nor it necessarily indicates the presence of sleep apnea...
  23. ncbi REM sleep behavior disorder
    L Ferini-Strambi
    Sleep Disorders Center, Istituto Scientifico H San Raffaele, Via Prinetti 27, 20127, Milano, Italy
    Clin Neurophysiol 111:S136-40. 2000
    ..Most importantly, RBD is readily diagnosable and treatable. Patients and their bed partners usually report immediate improvement in sleep-related motor behavior with small doses of clonazepam...
  24. ncbi Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist?
    L Ferini-Strambi
    Sleep Disorders Center, Universita Vita Salute San Raffaele, Milano, Italy
    Neurology 62:41-5. 2004
    ..To evaluate the cognitive performance of patients with idiopathic REM sleep behavior disorder (RBD)...
  25. ncbi Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP)
    L Ferini-Strambi
    Sleep Disorders Center, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127 Milano, Italy
    Brain Res Bull 61:87-92. 2003
    ..The findings of this study confirm the hypothesis of partial reversibility of cognitive dysfunction in OSA patients after CPAP...
  26. ncbi The impact of cyclic alternating pattern on heart rate variability during sleep in healthy young adults
    L Ferini-Strambi
    Sleep Disorders Center, University of Milano and IRCCS H San Raffaele, Milan, Italy
    Clin Neurophysiol 111:99-101. 2000
    ..The aim of our study was to evaluate HR variability in relation to CAP during non-REM sleep in healthy adults...
  27. doi Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD?
    Luigi Ferini-Strambi
    Sleep Disorders Center, Vita Salute San Raffaele University, Milan, Italy
    Sleep Med 12:S43-9. 2011
    ....
  28. ncbi Autosomal dominant restless legs syndrome maps on chromosome 14q
    Maria Teresa Bonati
    Human Molecular Genetics Unit, Department of Neuroscience, DIBIT San Raffaele Scientific Institute, Milan, Italy
    Brain 126:1485-92. 2003
    ..The complementary clinical and genetic studies on multiplex families are likely to be of the utmost importance in unfolding the complete expressivity of RLS phenotype spectrum...
  29. ncbi First night efficacy of pramipexole in restless legs syndrome and periodic leg movements
    Mauro Manconi
    Sleep Disorders Center, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Vita Salute University, Milan, Italy
    Sleep Med 8:491-7. 2007
    ..Restless legs syndrome (RLS) seems to improve immediately after a single dose of dopamine-agonists (DA). The aim of the present study was to investigate the acute effects of a low standard dose of pramipexole in RLS drug-naïve patients...
  30. ncbi Nocturnal eating: sleep-related eating disorder or night eating syndrome? A videopolysomnographic study
    Roberto Vetrugno
    Sleep Disorders Center, Department of Neurological Sciences, University of Bologna, Italy
    Sleep 29:949-54. 2006
    ..To describe the clinical and videopolysomnographic characteristics of nocturnal eating episodes in sleep-related eating disorder...
  31. ncbi The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Grou
    Marco Zucconi
    Sleep Disorders Center, San Raffaele Hospital, Milano, Italy
    Sleep Med 7:175-83. 2006
  32. pmc Time structure analysis of leg movements during sleep in REM sleep behavior disorder
    Mauro Manconi
    Sleep Disorders Center, Department of Neurology, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milan, Italy
    Sleep 30:1779-85. 2007
    ..To compare the time structure of leg movements (LM) during sleep of patients with rapid eye movement (REM) sleep behavior disorder (RBD) with that of patients with restless legs syndrome (RLS) or control subjects...
  33. pmc Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder
    Maria Livia Fantini
    Sleep Disorders Center, Universita Vita Salute San Raffaele, Milan, Italy
    Sleep 34:619-25. 2011
    ..To assess the longitudinal course of cognitive functions in a cohort of patients with idiopathic REM sleep behavior disorder (iRBD)...
  34. doi Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep
    Mauro Manconi
    Sleep Disorders Center, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Vita Salute University, Milan, Italy
    Sleep Med 12:47-55. 2011
    ..To compare heart rate variability (HRV) changes in patients with restless legs syndrome (RLS) and in healthy subjects, and to evaluate HRV before and after treatment with pramipexole in RLS patients...
  35. doi Association between bruxism and nocturnal groaning
    Mauro Manconi
    Center of Sleep Medicine, Department of Neurology, Scientific Institute of San Raffaele, Milan, Italy
    Mov Disord 23:737-9. 2008
    ..The hypothesis of a common trigger mechanism for NG and bruxism, through an arousal-induced activation, is discussed...
  36. ncbi Event-related potentials in idiopathic rapid eye movements sleep behaviour disorder
    Alberto Raggi
    Department of Neurology and Neurorehabilitation, San Raffaele Turro Hospital, Via Stamira d Ancona 20, 20127 Milan, Italy
    Clin Neurophysiol 118:669-75. 2007
    ..To assess psychophysiological parameters in idiopathic rapid eye movements sleep behaviour disorder (RBD), in order to identify possible markers for pre or sub-clinical cognitive abnormalities...
  37. ncbi Prevalence of habitual snoring and sleep-disordered breathing in preschool-aged children in an Italian community
    Vincenza Castronovo
    Sleep Disorders Center, IRCCS H San Raffaele, Milano, Italy
    J Pediatr 142:377-82. 2003
    ..To measure the prevalence of habitual snoring and sleep-disordered breathing in preschool-aged children...
  38. ncbi Topiramate treatment for nocturnal frontal lobe epilepsy
    Alessandro Oldani
    Sleep Disorders Center, Department of Neurology, HSR Turro and Università Vita Salute San Raffaele, Milan, Italy
    Seizure 15:649-52. 2006
    ..Aim of this study was to evaluate the efficacy and tolerability of the antiepileptic drug topiramate (TPM) in a sample of patients with nocturnal frontal lobe epilepsy (NFLE)...
  39. doi Validation study of the Italian version of the Insomnia Severity Index (ISI)
    Vincenza Castronovo
    Department of Clinical Neurosciences, Neurology, OSR Turro, Sleep Disorders Center, University San Raffaele, Milan, Italy
    Neurol Sci 37:1517-24. 2016
    ..75. The ISI questionnaire maintains good psychometric properties in the Italian version, thus confirming that this instrument is reliable for detecting insomnia severity and identifying patients' symptoms. ..
  40. pmc Defining the boundaries of the response of sleep leg movements to a single dose of dopamine agonist
    Mauro Manconi
    Sleep Disorders Center, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Vita Salute University, Milan, Italy
    Sleep 31:1229-37. 2008
    ..To define which leg movements (LM) associated with restless legs syndrome (RLS) respond to dopamine-agonist treatment and verify if they fall within current diagnostic criteria for periodic LM during sleep (PLMS)...
  41. doi Measuring the error in sleep estimation in normal subjects and in patients with insomnia
    Mauro Manconi
    Sleep Disorders Center, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Vita Salute University, Milan, Italy
    J Sleep Res 19:478-86. 2010
    ..The MI gives a reliable and immediate description of sleep misperception in healthy and insomnia subjects. Its application supports the existence of the high misperception of insomnia as a separate pathological entity...
  42. doi Pramipexole versus ropinirole: polysomnographic acute effects in restless legs syndrome
    Mauro Manconi
    Department of Neurology, Sleep Disorders Center, Scientific Institute and University Ospedale San Raffaele, Vita Salute University, Milan, Italy
    Mov Disord 26:892-5. 2011
    ..Pramipexole and ropinirole have become the first-line treatment for restless legs syndrome. The aim of this study was to perform the first direct comparison between these two molecules in restless legs syndrome...
  43. ncbi Case of symptomatic propriospinal myoclonus evolving toward acute "myoclonic status"
    Mauro Manconi
    Department of Neurology, Vita Salute University, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Turro, Milan, Italy
    Mov Disord 20:1646-50. 2005
    ..It is necessary to consider this severe progression and support it with prompt emergency maneuvers and adequate pharmacotherapy...
  44. ncbi Studio Morfeo: insomnia in primary care, a survey conducted on the Italian population
    Mario Giovanni Terzano
    Sleep Disorders Center, University of Parma, Via del Quartiere 4, Parma 43100, Italy
    Sleep Med 5:67-75. 2004
    ....
  45. ncbi Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder
    Maria Livia Fantini
    Sleep Disorders Center, Department of Neurology, Universita Vita Salute San Raffaele, via Stamira d Ancona n 20, 20127 Milan, Italy
    Brain Res Bull 70:386-90. 2006
    ..Pathological changes in the anterior olfactory nucleus and olfactory loss occur very early in the course of PD and DLB. The aim of the study was to assess olfactory function in a large group of idiopathic RBD patients...
  46. doi Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment
    Nicola Canessa
    Center for Cognitive Neuroscience, Vita Salute San Raffaele University, Milan, Italy
    Am J Respir Crit Care Med 183:1419-26. 2011
    ..Knowledge of the brain structures involved in OSA and the corresponding functional implications could provide clues to the pathogenesis of cognitive impairment and its reversibility in this disorder...
  47. ncbi Frontal lobe epilepsy and mutations of the corticotropin-releasing hormone gene
    Romina Combi
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
    Ann Neurol 58:899-904. 2005
    ..In vitro experiments showed altered levels of gene expression. CRH alterations could explain several autosomal dominant nocturnal frontal lobe epilepsy clinical features...
  48. ncbi Cabergoline is an effective single-drug treatment for restless legs syndrome: clinical and actigraphic evaluation
    Marco Zucconi
    Sleep Disorders Center, Department of Neurology, H San Raffaele Scientific Institute and Hospital, Universita Vita Salute San Raffaele, Milan, Italy
    Sleep 26:815-8. 2003
    ..To evaluate the efficacy and the safety of cabergoline, a dopamine-receptor agonist with a long half-life, in restless legs syndrome (RLS)...
  49. doi Neurocognitive function in patients with idiopathic Restless Legs Syndrome before and after treatment with dopamine-agonist
    Andrea Galbiati
    San Raffaele Scientific Institute, Dept of Clinical Neurosciences, Sleep Disorders Center, Milan, Italy Vita Salute San Raffaele University, Faculty of Psychology, Milan, Italy
    Int J Psychophysiol 95:304-9. 2015
    ..All these functions improved after pharmacological treatment, as well as quality of life, depressive and anxiety symptoms, and daytime sleepiness. ..
  50. pmc Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study
    Birgit Frauscher
    From the Department of Neurology B F, D G, T M, B H, Innsbruck Medical University, Austria Danish Center for Sleep Medicine P J, University of Copenhagen, Denmark Department of Neurology Y E S J, Washington University School of Medicine, St Louis, MO Department of Neurology R B P, McGill University, Montreal General Hospital, Canada Unité des Pathologies du Sommeil I A, S L S, Hopital Pitie Salpetriere, APHP, and Inserm U975 CRICM Pierre and Marie Curie University, Paris Sleep Unit V C D C, Y D, Department of Neurology, Hopital Gui de Chauliac, Montpellier, Inserm U1061, Montpellier, France Sleep Disorders Center M L F, Department of Neurosciences, University of Turin, Italy UFR Medecine M L F, EA 7280, University Clermont 1, France Sleep Disorders Center L F S, M Z, Universita Vita Salute San Raffaele, Milan, Italy Neurology Service A I, J S, Hospital Clinic de Barcelona
    Neurology 82:1076-9. 2014
    ..This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort...
  51. pmc Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study
    Mauro Manconi
    Sleep Disorders Center, Scientific Institute and Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Sleep 31:944-52. 2008
    ..To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors...
  52. doi Clinical pharmacology and efficacy of rotigotine (Neupro® patch) in the treatment of restless leg syndrome
    Luigi Ferini-Strambi
    a Division of Neuroscience, Sleep Disorders Center, Ospedale San Raffaele and Università Vita Salute San Raffaele, Milan, Italy
    Expert Opin Drug Metab Toxicol 12:967-75. 2016
    ..In such cases a long-acting drug like rotigotine should be considered...
  53. ncbi National validation and proposed revision of REM sleep behavior disorder screening questionnaire (RBDSQ)
    Sara Marelli
    Department of Clinical Neurosciences, Neurology, Sleep Disorders Center, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, via Stamira D Ancona, 20, 20127, Milan, Italy
    J Neurol 263:2470-2475. 2016
    ....
  54. doi Impaired visual processing in patients with insomnia disorder revealed by a dissociation in visual search
    Enrico Giora
    Faculty of Psychology, Vita Salute San Raffaele University, Milan, Italy
    J Sleep Res . 2016
    ..These results experimentally demonstrate the presence of a daytime impairment in patients with insomnia disorder revealed by a dissociation in visual search, and are discussed in the light of the hyperarousal concept of insomnia...
  55. pmc Behavioural and Cognitive-Behavioural Treatments of Parasomnias
    Andrea Galbiati
    Department of Clinical Neurosciences and Department of Neurology, Sleep Disorders Center, San Raffaele Scientific Institute, 20127 Milan, Italy Faculty of Psychology, Vita Salute San Raffaele University, 20132 Milan, Italy
    Behav Neurol 2015:786928. 2015
    ..Due to the rarity of some parasomnias, further multicentric researches are needed in order to offer a more complete account of behavioural and cognitive-behavioural treatments efficacy. ..
  56. ncbi Respiratory monitoring by means of an unattended device in children with suspected uncomplicated obstructive sleep apnea: a validation study
    Marco Zucconi
    Sleep Disorders Center, Department of Neurology, and Statistic Unit, IRCCS H San Raffaele, Milan, Italy
    Chest 124:602-7. 2003
    ..To compare an unattended device for cardiorespiratory monitoring (POLY-MESAM; MAP; Martinsried, Germany) [P-M] with classic nocturnal polysomnography (PSG) for diagnosis of obstructive sleep apnea (OSA) in children...
  57. ncbi Multivariate and multiorgan analysis of cardiorespiratory variability signals: the CAP sleep case
    Anna M Bianchi
    Department of Biomedical Engineering, Polytechnic University of Milano, Milano, Italy
    Biomed Tech (Berl) 51:167-73. 2006
    ..During 2 CAP MC, the increased synchronization involved myoclonus and respiration. The underlying mechanism seems to be related to a global control system at the central level that involves the different systems...
  58. doi Effect of pramipexole on RLS symptoms and sleep: a randomized, double-blind, placebo-controlled trial
    Luigi Ferini-Strambi
    Institute San Raffaele Turro, Milan, Italy
    Sleep Med 9:874-81. 2008
    ..Our goal was to test the ability of pramipexole to improve sleep in RLS patients and to reconfirm its efficacy for primary RLS symptoms...
  59. doi Severe Brain Metabolic Decreases Associated with REM Sleep Behavior Disorder in Dementia with Lewy Bodies
    Leonardo Iaccarino
    Vita Salute San Raffaele University and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    J Alzheimers Dis 52:989-97. 2016
    ....
  60. doi A TRAPPC6B splicing variant associates to restless legs syndrome
    Paolo Aridon
    Vita Salute San Raffaele University and Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy Dipartimento di Biomedicina sperimentale e Neuroscienze Cliniche BioNec, Universita di Palermo, Palermo, Italy
    Parkinsonism Relat Disord 31:135-138. 2016
    ..RLS is a common movement disorders with a strong genetic component in its pathophysiology, but, up to now, no causative mutation has been reported...
  61. doi The behavioural features of fatal familial insomnia: A new Italian case with pathological verification
    Alberto Raggi
    Department of Clinical Neurosciences, San Raffaele Turro Hospital, 20127 Milan, Italy
    Sleep Med 10:581-5. 2009
    ..We report a new, pathologically verified Italian case of fatal familial insomnia, whose clinical presentation was characterised by complex behavioural disturbances, suggesting wakefulness/NREM/REM combinations...
  62. ncbi Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview
    Romina Combi
    Department of Biology and Genetics for, Medical Sciences University of Milan, via Viotti 3 5, 20133, Milan, Italy
    J Neurol 251:923-34. 2004
    ..This is an overview on the clinical and genetic aspects of ADNFLE including a discussion of some open questions on the role of the neuronal nicotinic receptor subunit mutations in the pathogenesis of this form of epilepsy...
  63. ncbi Epidemiology and clinical findings of restless legs syndrome
    Marco Zucconi
    Department of Neurology, Sleep Disorders Center, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20 127 Milan, Italy
    Sleep Med 5:293-9. 2004
    ....
  64. ncbi Studio Morfeo 2: survey on the management of insomnia by Italian general practitioners
    Mario Giovanni Terzano
    Department of Neuroscience, Sleep Disorders Center, University of Parma, Via Gramsci, 14, 43100 Parma, Italy
    Sleep Med 7:599-606. 2006
    ..To carry out an observational epidemiological survey (Studio Morfeo 2) in order to define the management procedures of insomnia in a large Italian population presenting directly to the general practitioner (GP)...
  65. doi Expression of mutant beta2 nicotinic receptors during development is crucial for epileptogenesis
    Irene Manfredi
    San Raffaele Scientific Institute, Milan, Italy
    Hum Mol Genet 18:1075-88. 2009
    ..Our data indicate that mutant nicotinic receptors are responsible for abnormal formation of neuronal circuits and/or long-lasting alteration of network assembly in the developing brain, thus leading to epilepsy...
  66. ncbi Response to Clinical Corners case (Sleep Medicine 6/2: 83-4): Pregnancy associated with daytime sleepiness and nighttime restlessness
    Mauro Manconi
    Department of Neurology, Sleep Disorders Center, Vita Salute University, IRCCS H S Raffaele, Milan, Italy
    Sleep Med 6:477-8. 2005
  67. pmc Sleep in genetically confirmed pantothenate kinase-associated neurodegeneration: a video-polysomnographic study
    Maria Livia Fantini
    Sleep Disorders Center, Department of Clinical Neurosciences, Vita Salute San Raffaele University, H San Raffaele Turro, 20127 Milan, Italy
    Parkinsons Dis 2010:342834. 2010
    ..Sleep studies may phenotypically differentiate PKAN from other neurodegenerative disorders...
  68. ncbi NREM sleep alterations in narcolepsy/cataplexy
    Raffaele Ferri
    Department of Neurology IC, Sleep Research Centre, Oasi Institute IRCCS, Troina, Enna, Italy
    Clin Neurophysiol 116:2675-84. 2005
    ..NREM sleep patterns of narcoleptic patients with cataplexy were studied, focusing on their sleep 'microstructure', by analyzing the cyclic alternating pattern (CAP)...
  69. ncbi Parkinsonism with excessive daytime sleepiness--a narcolepsy-like disorder?
    Christian Baumann
    Neurologische Poliklinik, Universitatsspital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
    J Neurol 252:139-45. 2005
    ..In these patients a narcolepsy-like pathophysiology of sleep-wake disturbances has been suggested...
  70. ncbi Computer-assisted detection of nocturnal leg motor activity in patients with restless legs syndrome and periodic leg movements during sleep
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute IRCCS, Troina, Italy
    Sleep 28:998-1004. 2005
    ..To assess the performance of a new method for automatic detection of periodic leg movements during sleep...
  71. ncbi Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study
    Wayne Hening
    Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
    Sleep Med 5:237-46. 2004
    ..To assess the frequency, impact, and medical response to the restless legs syndrome (RLS) in a large multi-national primary care population...
  72. ncbi Heart rate and spectral EEG changes accompanying periodic and non-periodic leg movements during sleep
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute IRCCS, 94018 Troina, Italy
    Clin Neurophysiol 118:438-48. 2007
    ..To evaluate the changes in heart rate (HR) and EEG spectra accompanying periodic (PLM) and non-periodic leg movements (NPLM) during sleep in patients with restless legs syndrome (RLS)...
  73. ncbi New approaches to the study of periodic leg movements during sleep in restless legs syndrome
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Troina, Italy
    Sleep 29:759-69. 2006
    ..To describe a new approach for the analysis of quantity, type, and periodicity of the leg motor activity during sleep in patients with restless legs syndrome (RLS) and periodic leg movements (PLM)...
  74. ncbi Health-related quality of life in Italian patients with narcolepsy: the SF-36 health survey
    Luca Vignatelli
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    Sleep Med 5:467-75. 2004
    ..To compare the HRQoL of patients with narcolepsy with the Italian norm. To disclose the clinical predictors influencing the HRQoL...
  75. ncbi Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Troina, Italy
    Sleep 29:1587-94. 2006
    ..To analyze periodic leg movements (PLM) during sleep in patients with narcolepsy and compare the results with those obtained in normal controls and subjects with restless legs syndrome (RLS)...
  76. ncbi Emotional information processing in patients with narcolepsy: a psychophysiologic investigation
    Valter Tucci
    Department of Psychology, University of Padua, Padua, Italy
    Sleep 26:558-64. 2003
    ..Accordingly, we compared the psychophysiologic effects on patients with narcolepsy and healthy subjects of processing visual stimuli that have established emotional valences...
  77. doi Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Kassel, Germany
    Lancet Neurol 7:595-604. 2008
    ..Continuous administration of a dopamine agonist could be used to treat patients with restless legs syndrome. Our aim was to investigate the efficacy of transdermal rotigotine in the treatment of idiopathic restless legs syndrome...
  78. pmc Catathrenia (nocturnal groaning): what is it?
    Roberto Vetrugno
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Sleep 31:308-9. 2008
  79. doi A quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorder
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute IRCCS, Troina, Italy
    J Sleep Res 17:89-100. 2008
    ....
  80. ncbi Sleep and quantitative EEG in neurodegenerative disorders
    Dominique Petit
    Centre d étude du sommeil et des rythmes diologiques, Hôpital du Sacré Coeur, Montreal, Quebec, Canada
    J Psychosom Res 56:487-96. 2004
    ..The study of sleep variables and that of the spectral composition of the EEG can provide valuable information for understanding the pathophysiology and for assisting the diagnosis of neurodegenerative diseases...
  81. ncbi Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy
    Stefano Duga
    Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti, 3 5 20133 Milan, Italy
    Epilepsia 43:362-4. 2002
    ..In none of the patients were mutations in the analyzed region of CHRNB2 found. These data, obtained in the largest ADNFLE cohort so far analyzed, demonstrate the rarity of the identified CHRNB2 mutations in ADNFLE patients...
  82. ncbi Restless legs syndrome among pregnant women
    Mauro Manconi
    Sleep 27:350; author reply 351. 2004
  83. ncbi Pramipexole in Restless Legs syndrome. Evaluation by suggested immobilization test
    Mauro Manconi
    J Neurol 250:1494-5. 2003
  84. ncbi Exclusion of linkage of nine neuronal nicotinic acetylcholine receptor subunit genes expressed in brain in autosomal dominant nocturnal frontal lobe epilepsy in four unrelated families
    Maria Teresa Bonati
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    J Neurol 249:967-74. 2002
    ..These findings support the hypothesis that genes different from those coding for alpha2-7 and beta2-4 neuronal nAChR subunits could be responsible for ADNFLE...
  85. ncbi Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome
    Diego Garcia-Borreguero
    Fundacion Jimenez Diaz, Madrid, Spain
    Sleep Med 8:455-63. 2007
    ..The changes in each dimension are summed to give an ASRS total score...
  86. ncbi Evidence for a fourth locus for autosomal dominant nocturnal frontal lobe epilepsy
    Romina Combi
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    Brain Res Bull 63:353-9. 2004
    ..These data strongly suggest that ENFL1, ENFL2 and ENFL3 are minor loci for the disease and point to the existence of at least a fourth locus for ADNFLE...
  87. ncbi Idiopathic REM sleep behavior disorder: toward a better nosologic definition
    Maria Livia Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré Coeur, Montreal, Canada
    Neurology 64:780-6. 2005
    ..Identifying subjects with a high risk of developing a neurodegenerative process may be crucial in order to develop early intervention strategies...
  88. ncbi Restless legs syndrome prevalence and impact: REST general population study
    Richard P Allen
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21224, USA
    Arch Intern Med 165:1286-92. 2005
    ..Previous epidemiological studies, however, have failed to determine the prevalence of those with clinically significant RLS symptoms and to examine the life effects and medical experiences of this group...
  89. ncbi Two new putative susceptibility loci for ADNFLE
    Romina Combi
    Department of Biology and Genetics for Medical Sciences, University of Milano, Italy
    Brain Res Bull 67:257-63. 2005
    ..In particular, we propose and discuss the hypothesis of a digenic transmission of the disease...
  90. ncbi Sleep disturbances and teacher ratings of school achievement and temperament in children
    Oliviero Bruni
    Department of Developmental Neurology and Psychiatry, Center for Pediatric Sleep Disorders, University of Rome La Sapienza, Via dei Sabelli 108, 00185 Rome, Italy
    Sleep Med 7:43-8. 2006
    ..The current study examined the relationships between academic achievement, sleep, temperament and demographic-historical data in school-age children...
  91. ncbi Genetics of restless legs syndrome
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Munich Neuherberg, Germany
    Sleep Med Rev 10:179-83. 2006
    ..It is important to investigate whether further RLS families show linkage to one of these loci to discuss the contribution of these loci and to provide a prerequisite of a mutational screening and identification of the RLS genes...
  92. ncbi Family-based association study of the restless legs syndrome loci 2 and 3 in a European population
    David Kemlink
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
    Mov Disord 22:207-12. 2007
    ..0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS...
  93. ncbi Burden of restless legs syndrome on health-related quality of life
    Clete Kushida
    Stanford Center of Excellence for Sleep Disorders, Stanford, CA, USA
    Qual Life Res 16:617-24. 2007
    ..To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL)...
  94. ncbi State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndrome
    Wolfgang H Oertel
    Department of Neurology, Philipps University, Marburg, Germany
    Mov Disord 22:S466-75. 2007
    ..Opioids and anticonvulsants such as gabapentine are second-line options in individual patients. Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 microg/L)...
  95. ncbi Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
    Mov Disord 22:S495-504. 2007
    ..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols...
  96. ncbi Left thalamomegaly in a patient with partial epilepsy
    Giacomo Della Marca
    Department of Neurosciences, Catholic University, Rome, Italy
    Clin Neurol Neurosurg 110:298-301. 2008
    ..18-FDG PET showed reduced metabolic activity in the upper right temporal gyrus and in the ipsilateral thalamus. Thalamic asymmetry in our patient could be an occasional finding...
  97. ncbi Restless legs syndrome: prevalence and impact in children and adolescents--the Peds REST study
    Daniel Picchietti
    University of Illinois School of Medicine and Carle Clinic Association, Department of Pediatrics, 602 W University Ave, Urbana, IL 61801, USA
    Pediatrics 120:253-66. 2007
    ..In this first population-based study to use specific pediatric diagnostic criteria, we examined the prevalence and impact of restless legs syndrome in 2 age groups: 8 to 11 and 12 to 17 years...