Luigi Ferini-Strambi


Affiliation: San Raffaele Scientific Institute
Country: Italy


  1. Ferini Strambi L, Marelli S, Galbiati A, Rinaldi F, Giora E. REM Sleep Behavior Disorder (RBD) as a marker of neurodegenerative disorders. Arch Ital Biol. 2014;152:129-46 pubmed publisher
    ..Some prospective results in iRBD showed that potential markers of neurodegeneration are the following: 1) marked EEG slowing on spectral analysis; 2) decreased striatal 123I-FPCIT; 3) impaired color vision. ..
  2. Galbiati A, Verga L, Giora E, Zucconi M, Ferini Strambi L. The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies. Sleep Med Rev. 2018;43:37-46 pubmed publisher
    ..Future studies should include control group for the evaluation of REM sleep without atonia as marker for neurodegeneration also in non-clinical population and target RBD as precursor of neurodegeneration to develop protective trials. ..
  3. Canessa N, Castronovo V, Cappa S, Marelli S, Iadanza A, Falini A, et al. Sleep apnea: Altered brain connectivity underlying a working-memory challenge. Neuroimage Clin. 2018;19:56-65 pubmed publisher
  4. Castronovo V, Galbiati A, Sforza M, Poletti M, Giarolli L, Kuo T, et al. Long-term clinical effect of group cognitive behavioral therapy for insomnia: a case series study. Sleep Med. 2018;47:54-59 pubmed publisher
    ..These findings have an important clinical implication both suggesting and confirming that CBT-I can be considered the treatment of choice for insomnia. ..
  5. Ferini Strambi L, Di Gioia M, Castronovo V, Oldani A, Zucconi M, Cappa S. Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist?. Neurology. 2004;62:41-5 pubmed
    ..Visuospatial constructional dysfunction and altered visuospatial learning may be present in idiopathic RBD. A neuropsychological assessment may be indicated in RBD patients. ..
  6. Galbiati A, Marelli S, Giora E, Zucconi M, Oldani A, Ferini Strambi L. Neurocognitive function in patients with idiopathic Restless Legs Syndrome before and after treatment with dopamine-agonist. Int J Psychophysiol. 2015;95:304-9 pubmed publisher
    ..All these functions improved after pharmacological treatment, as well as quality of life, depressive and anxiety symptoms, and daytime sleepiness. ..
  7. Ferini Strambi L. Treatment options for restless legs syndrome. Expert Opin Pharmacother. 2009;10:545-54 pubmed
    ..A treatment on demand is a clinical need in RLS cases that present intermittent symptoms. ..
  8. Ferini Strambi L, Zucconi M. REM sleep behavior disorder. Clin Neurophysiol. 2000;111 Suppl 2:S136-40 pubmed
    ..Most importantly, RBD is readily diagnosable and treatable. Patients and their bed partners usually report immediate improvement in sleep-related motor behavior with small doses of clonazepam. ..
  9. Ferini Strambi L. Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD?. Sleep Med. 2011;12 Suppl 2:S43-9 pubmed publisher

More Information


  1. Ferini Strambi L, Rinaldi F, Giora E, Marelli S, Galbiati A. REM sleep Behaviour Disorder. Parkinsonism Relat Disord. 2016;22 Suppl 1:S69-72 pubmed publisher
  2. Ferini Strambi L. RLS-like symptoms: differential diagnosis by history and clinical assessment. Sleep Med. 2007;8 Suppl 2:S3-6 pubmed
  3. Rinaldi F, Galbiati A, Marelli S, Cusmai M, Gasperi A, Oldani A, et al. Defining the phenotype of restless legs syndrome/Willis-Ekbom disease (RLS/WED): a clinical and polysomnographic study. J Neurol. 2016;263:396-402 pubmed publisher
    ..This draws attention on the importance of a careful evaluation of the patient, to recognize potentially treatable secondary forms of RLS/WED. ..
  4. Ferini Strambi L, Marelli S, Combi R. Does the Type of Multisystem Atrophy, Parkinsonism, or Cerebellar Ataxia Impact on the Nature of Sleep Disorders?. Curr Neurol Neurosci Rep. 2016;16:105 pubmed
    ..These findings suggest that although the dominant clinical presentations differ between MSA-C and MSA-P, a common pathophysiology may underlie both subtypes of MSA. ..
  5. Ferini Strambi L, Lombardi G, Marelli S, Galbiati A. Neurological Deficits in Obstructive Sleep Apnea. Curr Treat Options Neurol. 2017;19:16 pubmed publisher
    ..This review clearly shows the importance of taking a sleep history in neurological patients and considering the diagnosis and specific treatment of OSA in these patients. ..
  6. Ferini Strambi L, Marelli S, Zucconi M, Galbiati A, Biggio G. Effects of different doses of triazolam in the middle-of-the-night insomnia: a double-blind, randomized, parallel group study. J Neurol. 2017;264:1362-1369 pubmed publisher
    ..This study demonstrates that low dose of triazolam objectively and subjectively improves the sleep of patients having MOTN insomnia. ..
  7. Ferini Strambi L, Bonati M, Oldani A, Aridon P, Zucconi M, Casari G. Genetics in restless legs syndrome. Sleep Med. 2004;5:301-4 pubmed
    ..However, the efforts toward the identification of RLS genes must continue in order to obtain a better characterization of the syndrome and to identify new therapeutic strategies. ..
  8. Castronovo V, Galbiati A, Marelli S, Brombin C, Cugnata F, Giarolli L, et al. Validation study of the Italian version of the Insomnia Severity Index (ISI). Neurol Sci. 2016;37:1517-24 pubmed publisher
    ..75. The ISI questionnaire maintains good psychometric properties in the Italian version, thus confirming that this instrument is reliable for detecting insomnia severity and identifying patients' symptoms. ..
  9. Galbiati A, Abutalebi J, Iannaccone S, Borsa V, Musteata S, Zucconi M, et al. The effects of Transcranial Direct Current Stimulation (tDCS) on Idiopathic Hypersomnia: a pilot study. Arch Ital Biol. 2016;154:1-5 pubmed publisher
    ..Our results indicate that tDCS may foster the management of EDS in IH, improving also the attentional domain. ..
  10. Marelli S, Rancoita P, Giarrusso F, Galbiati A, Zucconi M, Oldani A, et al. National validation and proposed revision of REM sleep behavior disorder screening questionnaire (RBDSQ). J Neurol. 2016;263:2470-2475 pubmed
  11. Garbarino S, Guglielmi O, Campus C, Mascialino B, Pizzorni D, Nobili L, et al. Screening, diagnosis, and management of obstructive sleep apnea in dangerous-goods truck drivers: to be aware or not?. Sleep Med. 2016;25:98-104 pubmed publisher
    ..Untreated subjects with severe OSA had a significantly increased risk of NMAs. In professional drivers, screening, treatment, and management of OSA are mandatory for reducing road accident risk and improving road safety. ..
  12. Ferini Strambi L, Sforza M, Poletti M, Giarrusso F, Galbiati A. Daytime sleepiness: more than just Obstructive Sleep Apnea (OSA). Med Lav. 2017;108:260-266 pubmed publisher
  13. Ferini Strambi L. Neuropathic Pain and Sleep: A Review. Pain Ther. 2017;6:19-23 pubmed publisher
    ..Opioids and antidepressants are effective in reducing pain but can exacerbate sleep disturbances. Pfizer, Italy. ..
  14. Ferini Strambi L, Fantini M, Zucconi M, Castronovo V, Marelli S, Oldani A, et al. REM sleep behaviour disorder. Neurol Sci. 2005;26 Suppl 3:s186-92 pubmed
    ..The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies...
  15. Giora E, Galbiati A, Marelli S, Zucconi M, Ferini Strambi L. Evidence of perceptive impairment in OSA patients investigated by means of a visual search task. Cortex. 2017;95:136-142 pubmed publisher
    ..This study indicates the presence of an impairment in OSA patients involving basic mechanisms of visual processing and likely ascribable to the disorder per se. ..