Angelo Corti

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. doi request reprint Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy
    Arianna Calcinotto
    Cellular Immunology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 188:2687-94. 2012
  2. ncbi request reprint Chromogranin A and the endothelial barrier function
    A Corti
    Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Curr Med Chem 19:4051-8. 2012
  3. doi request reprint Targeted drug delivery and penetration into solid tumors
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Med Res Rev 32:1078-91. 2012
  4. ncbi request reprint Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs
    Angelo Corti
    Department of Biological and Technological Research, Cancer Immunotherapy and Gene Therapy Programme, San Raffaele H Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Ann N Y Acad Sci 1028:104-12. 2004
  5. doi request reprint Isoaspartate-dependent molecular switches for integrin-ligand recognition
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Cell Sci 124:515-22. 2011
  6. doi request reprint Chromogranin A and the tumor microenvironment
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Cell Mol Neurobiol 30:1163-70. 2010
  7. pmc The neovasculature homing motif NGR: more than meets the eye
    Angelo Corti
    DIBIT Department of Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Blood 112:2628-35. 2008
  8. ncbi request reprint Tumor vasculature targeting through NGR peptide-based drug delivery systems
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Curr Pharm Biotechnol 12:1128-34. 2011
  9. pmc Critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switching
    Flavio Curnis
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, 20132 Milan
    J Biol Chem 285:9114-23. 2010
  10. doi request reprint Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma
    Anna Maria Gasparri
    Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Mol Cancer Ther 7:3859-66. 2008

Collaborators

Detail Information

Publications62

  1. doi request reprint Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy
    Arianna Calcinotto
    Cellular Immunology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 188:2687-94. 2012
    ..Thus, these findings might be relevant for the design of novel immunotherapeutic approaches for cancer patients...
  2. ncbi request reprint Chromogranin A and the endothelial barrier function
    A Corti
    Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Curr Med Chem 19:4051-8. 2012
    ....
  3. doi request reprint Targeted drug delivery and penetration into solid tumors
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Med Res Rev 32:1078-91. 2012
    ....
  4. ncbi request reprint Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs
    Angelo Corti
    Department of Biological and Technological Research, Cancer Immunotherapy and Gene Therapy Programme, San Raffaele H Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Ann N Y Acad Sci 1028:104-12. 2004
    ..Vascular targeting, either indirectly with NGR-TNF-alpha or directly with NGR-targeted liposomes, could be a novel strategy for increasing the therapeutic index of chemotherapeutic drugs...
  5. doi request reprint Isoaspartate-dependent molecular switches for integrin-ligand recognition
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Cell Sci 124:515-22. 2011
    ....
  6. doi request reprint Chromogranin A and the tumor microenvironment
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Cell Mol Neurobiol 30:1163-70. 2010
    ....
  7. pmc The neovasculature homing motif NGR: more than meets the eye
    Angelo Corti
    DIBIT Department of Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Blood 112:2628-35. 2008
    ....
  8. ncbi request reprint Tumor vasculature targeting through NGR peptide-based drug delivery systems
    Angelo Corti
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Curr Pharm Biotechnol 12:1128-34. 2011
    ..Here we review the reports on these conjugates and discuss the structural, functional and stability properties of NGR embedded into different molecular scaffolds...
  9. pmc Critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switching
    Flavio Curnis
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, 20132 Milan
    J Biol Chem 285:9114-23. 2010
    ..These findings may have important implications for the design and development of anticancer drugs or tumor neovasculature-imaging compounds, and for the potential function of different NGR/isoDGR sites in natural proteins...
  10. doi request reprint Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma
    Anna Maria Gasparri
    Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Mol Cancer Ther 7:3859-66. 2008
    ..Coadministration of IFNgamma-NGR with IDO inhibitors could represent a new strategy for increasing its antitumor activity...
  11. ncbi request reprint Targeted delivery of IFNgamma to tumor vessels uncouples antitumor from counterregulatory mechanisms
    Flavio Curnis
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, Milan, Italy
    Cancer Res 65:2906-13. 2005
    ..These findings suggest that antitumor activity and counterregulatory mechanisms could be uncoupled by tumor vascular targeting with extremely low doses of IFNgamma...
  12. ncbi request reprint Chromogranin A protects vessels against tumor necrosis factor alpha-induced vascular leakage
    Elisabetta Ferrero
    Department Biological and Technological Research DIBIT, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    FASEB J 18:554-6. 2004
    ....
  13. doi request reprint Synergistic damage of tumor vessels with ultra low-dose endothelial-monocyte activating polypeptide-II and neovasculature-targeted tumor necrosis factor-alpha
    Luca Crippa
    Department of Oncology, Cancer Immunotherapy Gene Therapy Program and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 68:1154-61. 2008
    ..Tumor vascular targeting with extremely low amounts of these cytokines may represent a new strategy for cancer treatment...
  14. ncbi request reprint Crucial role for interferon gamma in the synergism between tumor vasculature-targeted tumor necrosis factor alpha (NGR-TNF) and doxorubicin
    Angelina Sacchi
    Department of Biological and Technological Research and Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, Milan, Italy
    Cancer Res 64:7150-5. 2004
    ....
  15. ncbi request reprint Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-alpha
    Angelina Sacchi
    DIBIT Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, Milan, Italy
    Clin Cancer Res 12:175-82. 2006
    ..We have examined the antitumor activity of NGR-TNF in combination with various chemotherapeutic drugs acting via different mechanisms, including, besides doxorubicin and melphalan, cisplatin, paclitaxel, and gemcitabine...
  16. doi request reprint Vasculature-targeted tumor necrosis factor-alpha increases the therapeutic index of doxorubicin against prostate cancer
    Maria T S Bertilaccio
    Cancer Immunotherapy and Gene Therapy Program, Department of Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Prostate 68:1105-15. 2008
    ....
  17. doi request reprint Chromogranin A binds to αvβ6-integrin and promotes wound healing in mice
    Flavio Curnis
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Cell Mol Life Sci 69:2791-803. 2012
    ..These results suggest that the interaction of the RGD/α-helix motif of CgA with αvβ6 regulates keratinocyte physiology in wound healing...
  18. doi request reprint Isoaspartate-glycine-arginine: a new tumor vasculature-targeting motif
    Flavio Curnis
    Department of Biological and Technological Research, CIGT Program and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 68:7073-82. 2008
    ..These results suggest that isoDGR is a novel tumor vasculature-targeting motif. Peptides containing isoDGR could be exploited as ligands for targeted delivery of drugs, imaging agents, or other compounds to tumor vasculature...
  19. ncbi request reprint Spontaneous formation of L-isoaspartate and gain of function in fibronectin
    Flavio Curnis
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program and Italian Institute of Technology Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 281:36466-76. 2006
    ..Time-dependent generation of isoDGR may represent a sort of molecular clock for activating latent integrin binding sites in proteins...
  20. ncbi request reprint Inhibition of tumor growth by intramuscular injection of cDNA encoding tumor necrosis factor alpha coupled to NGR and RGD tumor-homing peptides
    Natasa Zarovni
    Department of Biological and Technological Research, and Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, 20132 Milan, Italy
    Hum Gene Ther 15:373-82. 2004
    ....
  21. doi request reprint Chromogranin A restricts drug penetration and limits the ability of NGR-TNF to enhance chemotherapeutic efficacy
    Eleonora Dondossola
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 71:5881-90. 2011
    ..Measuring CgA and its fragments may assist the selection of patients that can respond better to NGR-TNF/chemotherapy combinations in clinical trials...
  22. ncbi request reprint Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells
    Flavio Curnis
    Department of Pathology and Molecular Medicine, DIBIT San Raffaele H Scientific Institute, 20132 Milan, Italy
    Cancer Res 62:867-74. 2002
    ..These findings may explain the selectivity and the tumor-homing properties of NGR-drug conjugates and may have important implications in the development of vascular-targeted therapies based on the NGR/CD13 system...
  23. doi request reprint Circulating chromogranin A reveals extra-articular involvement in patients with rheumatoid arthritis and curbs TNF-alpha-elicited endothelial activation
    Gabriele Di Comite
    Department of Medicine, Oncology and Clinical Immunology Unit, H San Raffaele University Hospital, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    J Leukoc Biol 85:81-7. 2009
    ..Our results suggest that enhanced levels of CgA identify patients with extra-articular involvement and reveal a negative feedback loop that limits the activation of endothelial cells in RA...
  24. doi request reprint Role of vasostatin-1 C-terminal region in fibroblast cell adhesion
    Eleonora Dondossola
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Cell Mol Life Sci 67:2107-18. 2010
    ....
  25. ncbi request reprint Immunogenic and structural properties of the Asn-Gly-Arg (NGR) tumor neovasculature-homing motif
    Paola Di Matteo
    Department of Biological and Technological Research, San Raffaele H Scientific Institute, 20132 Milan, Italy
    Mol Immunol 43:1509-18. 2006
    ..These results suggest that NGR peptides could mimic from an immunological point of view a "self" structure, likely the GNGRG loop of fibronectin, with important implications for the use of these targeting peptides in patients...
  26. ncbi request reprint The vasostatin-I fragment of chromogranin A inhibits VEGF-induced endothelial cell proliferation and migration
    Daniela Belloni
    Department of Oncology and IIT Network Research Unit of Molecular Neurosciences, DIBIT, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    FASEB J 21:3052-62. 2007
    ..Conclusion: These findings suggest that vasostatin I may play a novel role as a regulator of endothelial cell function and homeostasis...
  27. pmc Enhanced expression of CD13 in vessels of inflammatory and neoplastic tissues
    Paola Di Matteo
    Molmed SpA, Milan, Italy
    J Histochem Cytochem 59:47-59. 2011
    ..This finding may be relevant for CD13-mediated vascular targeting therapies...
  28. ncbi request reprint Strategies for improving the anti-neoplastic activity of TNF by tumor targeting
    Angelo Corti
    Department of Biological and Technological Research, Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, Milan, Italy
    Methods Mol Med 98:247-64. 2004
    ..Thus, targeting markers that are selectively expressed or upregulated in angiogenic tumor vessels seems to be the best choice for developing TNF conjugates with improved activity...
  29. pmc Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
    Flavio Curnis
    Department of Biological and Technological Research, San Raffaele Hospital Scientific Institute, Milan, Italy
    J Clin Invest 110:475-82. 2002
    ..Vascular targeting could be a novel strategy for increasing the therapeutic index of chemotherapeutic drugs...
  30. doi request reprint Vascular targeting, chemotherapy and active immunotherapy: teaming up to attack cancer
    Matteo Bellone
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Trends Immunol 29:235-41. 2008
    ..This approach has the potential to empower chemoimmunotherapeutic strategies by improving cytotoxic drug penetration into tumors while exploiting the proinflammatory and immunostimulating activities of TNF-alpha and active immunotherapy...
  31. ncbi request reprint Characterisation of functional biotinylated TNF-alpha targeted to the membrane of apoptotic melanoma cells
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Programme, H San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    J Immunol Methods 276:79-87. 2003
    ..Therefore the bridging of TNF-alpha potentiates its biological function and influences the outcome of the phagocytic clearance of apoptotic tumor cells...
  32. doi request reprint The vasostatin-1 fragment of chromogranin A preserves a quiescent phenotype in hypoxia-driven endothelial cells and regulates tumor neovascularization
    Lorenzo Veschini
    Myeloma Unit, San Raffaele Scientific Institute, Milan, Italy
    FASEB J 25:3906-14. 2011
    ..Our findings highlight a previously undescribed function of VS-1 as a regulator of tumor vascularization...
  33. doi request reprint Structural basis for the interaction of isoDGR with the RGD-binding site of alphavbeta3 integrin
    Andrea Spitaleri
    Dulbecco Telethon Institute Biomolecular NMR Laboratory c o S Raffaele Scientific Institute, 20132 Milan, Italy
    J Biol Chem 283:19757-68. 2008
    ....
  34. ncbi request reprint Coupling tumor necrosis factor-alpha with alphaV integrin ligands improves its antineoplastic activity
    Flavio Curnis
    Department of Biological and Technological Research and Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, Milan, Italy
    Cancer Res 64:565-71. 2004
    ....
  35. doi request reprint IsoDGR-tagged albumin: a new αvβ3 selective carrier for nanodrug delivery to tumors
    Flavio Curnis
    Division of Molecular Oncology, San Raffaele Scientific Institute, Milan 20132, Italy
    Small 9:673-8. 2013
    ....
  36. ncbi request reprint Neuroendocrine modulation induced by selective blockade of TNF-alpha in rheumatoid arthritis
    Gabriele Di Comite
    Clinical Immunology and Rheumatology Unit, CIGTP, H San Raffaele Scientific Institute DIBIT and Vita Salute University, 3A1 Lab 3, Via Olgettina 58, 20132 Milan, Italy
    Ann N Y Acad Sci 1069:428-37. 2006
    ....
  37. doi request reprint Chromogranin A regulates tumor self-seeding and dissemination
    Eleonora Dondossola
    Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 72:449-59. 2012
    ..Inhibition of the multidirectional trafficking of cancer cells in normal and neoplastic tissues may represent a novel strategy to reduce cancer progression...
  38. doi request reprint Defining the optimal biological dose of NGR-hTNF, a selective vascular targeting agent, in advanced solid tumours
    Vanesa Gregorc
    Department of Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Eur J Cancer 46:198-206. 2010
    ..NGR-TNF showed a biphasic dose-response curve in preclinical models. This study exploring the low-dose range aimed to define safety and optimal biological dose of NGR-hTNF...
  39. ncbi request reprint Conversation galante: how the immune and the neuroendocrine systems talk to each other
    Gabriele Di Comite
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Autoimmun Rev 7:23-9. 2007
    ..A better molecular dissection of this finely regulated inter-system cross-talk, in physiological conditions and during self-sustaining inflammatory diseases, might enable more rational therapeutic approaches...
  40. pmc A new chromogranin A-dependent angiogenic switch activated by thrombin
    Luca Crippa
    Tumor Biology and Vascular Targeting Unit, Division of Molecular Oncology, San Raffaele Scientific Institute, Milan, Italy
    Blood 121:392-402. 2013
    ..Thrombin-induced alteration of this balance could provide a novel mechanism for triggering angiogenesis in pathophysiologic conditions characterized by prothrombin activation...
  41. ncbi request reprint Prognostic value of circulating chromogranin A and soluble tumor necrosis factor receptors in advanced nonsmall cell lung cancer
    Vanesa Gregorc
    Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Cancer 110:845-53. 2007
    ..The prognostic value of CgA and sTNF-Rs was investigated in advanced nonsmall cell lung cancer (NSCLC), a histologically heterogeneous group of tumors that may undergo neuroendocrine differentiation...
  42. doi request reprint Increased low-grade inflammation is associated with lack of functional response to carvedilol in patients with systolic heart failure
    Gabriele Fragasso
    Heart Failure Clinic Clinical Cardiology, Cardiothoracic and Vascular Department, San Raffaele University Hospital, Milan, Italy
    J Cardiovasc Med (Hagerstown) 14:49-56. 2013
    ..The aim of this study was to evaluate, according to functional response, the neuroendocrine and inflammatory status in patients with chronic heart failure before and after therapy with carvedilol...
  43. ncbi request reprint Cleavage of chromogranin A N-terminal domain by plasmin provides a new mechanism for regulating cell adhesion
    Barbara Colombo
    Department of Biological and Technological Research, San Raffaele H Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 277:45911-9. 2002
    ..Given the importance of plasminogen activation in tissue invasion and remodeling, the interplay between CgA and plasmin could provide a novel mechanism for regulating fibroblast adhesion and function in neuroendocrine tumors...
  44. ncbi request reprint Production and characterization of recombinant human and murine TNF
    Flavio Curnis
    Biological and Technological Research, Cancer Immunotherapy and Gene Therapy Program, San Raffaele H Scientific Institute, Milan, Italy
    Methods Mol Med 98:9-22. 2004
    ..The biological activity of both human and murine TNF is assessed by in vitro cytolytic assays using murine L-M cells. Purified hTNF and mTNF can be used for in vitro and in vivo studies in animal models...
  45. ncbi request reprint Chromogranin A N-terminal fragments vasostatin-1 and the synthetic CGA 7-57 peptide act as cardiostatins on the isolated working frog heart
    Angelo Corti
    Department of Biological and Technological Research, San Raffaele H Scientific Institute, Milan 20132, Italy
    Gen Comp Endocrinol 136:217-24. 2004
    ....
  46. ncbi request reprint Peptide microarrays for the characterization of antigenic regions of human chromogranin A
    Marcella Chiari
    Istituto di Chimica del Riconoscimento Molecolare, Milan, Italy
    Proteomics 5:3600-3. 2005
    ..The results reported in this article are in accordance with those obtained in conventional ELISA assays using biotinylated and non-biotinylated peptides...
  47. ncbi request reprint Chromogranin A expression in neoplastic cells affects tumor growth and morphogenesis in mouse models
    Barbara Colombo
    Department of Biological and Technological Research, San Raffaele H Scientific Institute, via Olettina 58, 20132 Milan, Italy
    Cancer Res 62:941-6. 2002
    ..These results suggest that abnormal secretion of CgA by neuroendocrine neoplastic cells could affect neoplastic growth and morphogenesis...
  48. pmc Immunomodulatory Agents with Antivascular Activity in the Treatment of Non-Small Cell Lung Cancer: Focus on TLR9 Agonists, IMiDs and NGR-TNF
    Angelo Corti
    Division of Molecular Oncology and IIT Network of Molecular Neuroscience, San Raffaele Scientific Institute University Hospital, 60 Olgettina St, 20132 Milan, Italy
    J Oncol 2010:732680. 2010
    ....
  49. ncbi request reprint TNF-alpha coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigens
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Scientific Institute and San Raffaele Vita Salute University, Milano, Italy
    J Immunol 172:2643-50. 2004
    ....
  50. ncbi request reprint The chromogranin A peptide vasostatin-I inhibits gap formation and signal transduction mediated by inflammatory agents in cultured bovine pulmonary and coronary arterial endothelial cells
    Anna Blois
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Regul Pept 135:78-84. 2006
    ..Furthermore, the inhibitory activity of vasostatin-I may be associated with the p38MAPK signalling cascade via a pertussis toxin sensitive, presumably Galphai coupled mechanism...
  51. ncbi request reprint Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Cancer Res 63:7400-9. 2003
    ..This combined strategy has the potential to overcome some major limitations of conventional chemotherapy...
  52. ncbi request reprint Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif
    Giorgio Colombo
    Consiglio Nazionale delle Ricerche, Istituto di Chimica del Riconoscimento Molecolare CNR ICRM, 20131 Milan, Italy
    J Biol Chem 277:47891-7. 2002
    ..The disulfide bridge constraint is critical for stabilizing the bent conformation and for increasing the tumor targeting efficiency...
  53. ncbi request reprint Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy
    Fabio Pastorino
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 66:10073-82. 2006
    ..Long-term survivors were obtained only in animals treated with the combined tumor- and vascular-targeted formulations, confirming the pivotal role of combination therapies in treating aggressive metastatic neuroblastoma...
  54. ncbi request reprint Inhibitory influence of chromogranin A N-terminal fragment (vasostatin-1) on the spontaneous contractions of rat proximal colon
    Antonella Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Regul Pept 130:42-7. 2005
    ..1 microM) or tetrodotoxin (TTX) (1 microM). The results suggest that VS-1 plays an inhibitory modulatory role on spontaneous contractions rat colon circular muscle, through mechanisms involving in part neural release of nitric oxide...
  55. ncbi request reprint Recombinant N-terminal fragments of chromogranin-A modulate cardiac function of the Langendorff-perfused rat heart
    Maria Carmela Cerra
    Department of Pharmaco Biology, University of Calabria, 87030, Arcavacata di Rende CS, Italy
    Basic Res Cardiol 101:43-52. 2006
    ..15, r2 = 0.97; -7.7 +/- 0.15, r2 = 0.97; -7.8 +/- 0.78, r2 = 0.55, respectively) revealed a non-competitive type of antagonism of STA-CGA1-78. Taken together, these data suggest vasostatins as novel cardioregulatory peptides in mammals...
  56. ncbi request reprint Characterization of natural vasostatin-containing peptides in rat heart
    Elise Glattard
    INSERM U575, Physiopathologie du Système Nerveux, Strasbourg, France
    FEBS J 273:3311-21. 2006
    ..This first identification of CGA-derived peptides containing the vasostatin motif in rat heart supports their role in cardiac physiology by an autocrine/paracrine mechanism...
  57. ncbi request reprint Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism
    Sandra Cappello
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Torino, Corso Raffaello 30, 10125 Turin, Italy
    Am J Physiol Heart Circ Physiol 293:H719-27. 2007
    ..As with repeated brief preconditioning ischemia, hrSTA-CgA(1-78) may be considered a stimulus strong enough to trigger both pathways, which may converge on PKC...
  58. ncbi request reprint Human recombinant vasostatin-1 may interfere with cell-extracellular matrix interactions
    Valentina Di Felice
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Italy
    Ann N Y Acad Sci 1090:305-10. 2006
    ..On the whole, these data suggest that VS-1 does not have a classic receptor on the membrane but that integrins may represent a nonconventional VS-1 receptor modulating eNOS signaling pathway...
  59. ncbi request reprint Crucial role of cytoskeleton reorganization in the negative inotropic effect of chromogranin A-derived peptides in eel and frog hearts
    Rosa Mazza
    Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    Regul Pept 138:145-51. 2007
    ..These results demonstrate that changes in cytoskeletal dynamics play a crucial role in the negative inotropic influence of VSs on eel and frog hearts...
  60. ncbi request reprint Influence of vasostatins, the chromogranin A-derived peptides, on the working heart of the eel (Anguilla anguilla): negative inotropy and mechanism of action
    Sandra Imbrogno
    Department of Cellular Biology, University of Calabria, Via P Bucci, Arcavacata di Rende 87030, CS, Italy
    Gen Comp Endocrinol 139:20-8. 2004
    ..These findings provide the first evidence that vasostatins exert cardiotropic action in fish, thus suggesting their long evolutionary history as well as their species-specific mechanisms of action...
  61. ncbi request reprint Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine
    Anna Blois
    Department of Biomedicine, Section of Physiology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Regul Pept 134:30-7. 2006
    ....
  62. ncbi request reprint Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function
    Maurizio Pieroni
    Cardiology Department, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Eur Heart J 28:1117-27. 2007
    ..High chromogranin-A (CgA) levels were observed in patients with heart failure but its source remained uncertain. We evaluated whether CgA is produced by myocardium and might affect myocardial function...