Giancarlo Comi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Variability in detection and quantification of interferon β-1b-induced neutralizing antibodies
    Hans Peter Hartung
    Heinrich Heine Universitat, Moorenstraße 5, Dusseldorf 40225, Germany
    J Neuroinflammation 9:129. 2012
  2. pmc Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures
    Alberto Lerario
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Centro Dino Ferrari, IRCCS Istituto Auxologico Italiano, Universita di Milano, Fondazione, Ospedale Maggiore Policlinico di Milano, Italy
    BMC Neurol 12:91. 2012
  3. doi request reprint MRI outcomes with cladribine tablets for multiple sclerosis in the CLARITY study
    Giancarlo Comi
    Department of Neurology and Institute of Experimental Neurology, Scientific Institute H S Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 260:1136-46. 2013
  4. doi request reprint Placebo-controlled trial of oral laquinimod for multiple sclerosis
    Giancarlo Comi
    Department of Neurology and Institute of Experimental Neurology, Universita Vita Salute San Raffaele, Milan, Italy
    N Engl J Med 366:1000-9. 2012
  5. ncbi request reprint Extracorporeal phototherapy in multiple sclerosis
    G Comi
    Institute of Experimental Neurology, University Vita Salute San Raffaele, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 27:3-4. 2006
  6. doi request reprint Effects of disease modifying treatments on cognitive dysfunction in multiple sclerosis
    Giancarlo Comi
    Department of Neurology, Scientific Institute San Raffaele, University Vita Salute, Milan, Italy
    Neurol Sci 31:S261-4. 2010
  7. doi request reprint Induction vs. escalating therapy in multiple sclerosis: practical implications
    Giancarlo Comi
    Department of Neurology, Scientic Institute San Raffaele, Via Olgettina 60, 20132, Milano, Italy
    Neurol Sci 29:S253-5. 2008
  8. doi request reprint Treatment of multiple sclerosis: role of natalizumab
    Giancarlo Comi
    Department of Neurology, Institute of Experimental Neurology, Scientific Institute San Raffaele Vita Salute University, Milan, Italy
    Neurol Sci 30:S155-8. 2009
  9. ncbi request reprint Multiple sclerosis: pseudotumoral forms
    G Comi
    Unità di Neurologia e Neuroriabilitazione, Istituto di Neurologia Sperimentale, Università Vita Salute S Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Neurol Sci 25:S374-9. 2004
  10. ncbi request reprint Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques
    G Comi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 172:S63-6. 2000

Detail Information

Publications196 found, 100 shown here

  1. pmc Variability in detection and quantification of interferon β-1b-induced neutralizing antibodies
    Hans Peter Hartung
    Heinrich Heine Universitat, Moorenstraße 5, Dusseldorf 40225, Germany
    J Neuroinflammation 9:129. 2012
    ..Interferon-beta (IFNB) therapy for multiple sclerosis can lead to the induction of neutralizing antibodies (NAbs) against IFNB. Various methods are used for detection and quantification of NAbs...
  2. pmc Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures
    Alberto Lerario
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Centro Dino Ferrari, IRCCS Istituto Auxologico Italiano, Universita di Milano, Fondazione, Ospedale Maggiore Policlinico di Milano, Italy
    BMC Neurol 12:91. 2012
    ..This study is to date the most thorough long-term evaluation of QMT in a cohort of DMD patients correlated with other measures, such as the North Star Ambulatory Assessment (NSAA) or three 6-min walk test (6MWT)...
  3. doi request reprint MRI outcomes with cladribine tablets for multiple sclerosis in the CLARITY study
    Giancarlo Comi
    Department of Neurology and Institute of Experimental Neurology, Scientific Institute H S Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 260:1136-46. 2013
    ..These findings add to our scientific understanding of the neurological impact of this therapeutic modality in patients with RRMS...
  4. doi request reprint Placebo-controlled trial of oral laquinimod for multiple sclerosis
    Giancarlo Comi
    Department of Neurology and Institute of Experimental Neurology, Universita Vita Salute San Raffaele, Milan, Italy
    N Engl J Med 366:1000-9. 2012
    ..Two proof-of-concept clinical trials have provided evidence that laquinimod reduces disease activity in patients with relapsing-remitting multiple sclerosis...
  5. ncbi request reprint Extracorporeal phototherapy in multiple sclerosis
    G Comi
    Institute of Experimental Neurology, University Vita Salute San Raffaele, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 27:3-4. 2006
  6. doi request reprint Effects of disease modifying treatments on cognitive dysfunction in multiple sclerosis
    Giancarlo Comi
    Department of Neurology, Scientific Institute San Raffaele, University Vita Salute, Milan, Italy
    Neurol Sci 31:S261-4. 2010
    ..However, results of these studies must be interpreted with great caution because many methodological problems may undermine the quality of the studies...
  7. doi request reprint Induction vs. escalating therapy in multiple sclerosis: practical implications
    Giancarlo Comi
    Department of Neurology, Scientic Institute San Raffaele, Via Olgettina 60, 20132, Milano, Italy
    Neurol Sci 29:S253-5. 2008
    ..Nevertheless, the decision to adopt a combination therapy in patients with a low response to monotherapy should not be delayed until severe irreversible disability is evident...
  8. doi request reprint Treatment of multiple sclerosis: role of natalizumab
    Giancarlo Comi
    Department of Neurology, Institute of Experimental Neurology, Scientific Institute San Raffaele Vita Salute University, Milan, Italy
    Neurol Sci 30:S155-8. 2009
    ..The final therapeutic decision is based on the evaluation of the disease state and prognosis, based on clinical and instrumental measures, and on the safety/efficacy profile of each treatment...
  9. ncbi request reprint Multiple sclerosis: pseudotumoral forms
    G Comi
    Unità di Neurologia e Neuroriabilitazione, Istituto di Neurologia Sperimentale, Università Vita Salute S Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Neurol Sci 25:S374-9. 2004
    ..In this paper, the main clinical, radiological and pathological characteristics of these forms are described. A short overview on the main treatments used in these cases is also provided...
  10. ncbi request reprint Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques
    G Comi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 172:S63-6. 2000
    ..Other factors, such as the site of MS lesions and the presence of active inflammation, also seem to play an important role...
  11. ncbi request reprint Early treatment
    G Comi
    Department of Neurology and Neurorehabilitation, Universita Vita Salute, Istituto Scientifico San Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Neurol Sci 27:S8-12. 2006
    ....
  12. doi request reprint Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study
    G Comi
    Department of Neurology, University Vita Salute and Scientific Institute San Raffaele, Milan, Italy
    Mult Scler 16:1360-6. 2010
    ..Laquinimod, an oral novel immunomodulator, was shown to reduce MRI-measured disease activity in relapsing-remitting MS (RRMS) patients...
  13. ncbi request reprint A multiparametric MRI study of frontal lobe dementia in multiple sclerosis
    G Comi
    Clinical Trials Unit, Department of Neuroscience, Scientific Institute H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 171:135-44. 1999
    ..Cerebellar MTR histogram metrics did not significantly differ in patients with and without cognitive decline. The presence of cognitive decline in MS is associated with the extent and pathological severity of brain MRI abnormalities...
  14. doi request reprint A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
    ..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology...
  15. ncbi request reprint Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
    ....
  16. ncbi request reprint Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Movement-associated cortical reorganisation is known to occur in multiple sclerosis (MS). We aimed to define the development of such cortical reorganisation by comparing data from patients with different disease phenotypes...
  17. doi request reprint Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
    ..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS...
  18. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  19. doi request reprint Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2844-51. 2009
    ....
  20. doi request reprint Brain macro- and microscopic damage in patients with paediatric MS
    Martina Absinta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:1357-62. 2010
    ....
  21. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  22. ncbi request reprint A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...
  23. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  24. ncbi request reprint The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
    ..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status...
  25. pmc Persistent inflammation alters the function of the endogenous brain stem cell compartment
    Stefano Pluchino
    Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Brain 131:2564-78. 2008
    ....
  26. doi request reprint Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  27. doi request reprint Motor area localization using fMRI-constrained cortical current density reconstruction of movement-related cortical potentials, a comparison with fMRI and TMS mapping
    Alberto Inuggi
    Department of Neurology, Neurophysiology and Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Milan, Italy
    Brain Res 1308:68-78. 2010
    ..This study confirms the usefulness of multimodal integration of fMRI, EEG and TMS in localizing M1 and the possibility to increase EEG spatial resolution using fMRI information...
  28. ncbi request reprint Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Maria A Rocca
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 18:847-55. 2003
    ..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage...
  29. ncbi request reprint Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:803-8. 2005
    ..Diffusion-tensor (DT) magnetic resonance imaging (MRI) has the potential to elucidate some characteristics of tissue microstructure inaccessible to other MRI techniques...
  30. ncbi request reprint Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:898-902. 2005
    ..Proton magnetic resonance spectroscopy (1H-MRS) can be used to measure in vivo whole-brain N-acetylaspartate (WBNAA) concentrations, the decrease of whose levels is considered a marker of neuronal-axonal injury...
  31. doi request reprint Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Ann Neurol 66:343-54. 2009
    ....
  32. doi request reprint Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
    Gianna Riccitelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 32:1535-43. 2011
    ..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype...
  33. doi request reprint Thalamic damage and long-term progression of disability in multiple sclerosis
    Maria Assunta Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 257:463-9. 2010
    ....
  34. ncbi request reprint Impaired short-term motor learning in multiple sclerosis: evidence from virtual reality
    Letizia Leocani
    Department of Neurology, Clinical Neurophysiology and Neurorehabilitation, University Vita Salute, Scientific Institute Hospital San Raffaele, Milan, Italy
    Neurorehabil Neural Repair 21:273-8. 2007
    ..The objective of this study was to investigate the usefulness of VR in the assessment of short-term motor learning in multiple sclerosis (MS)...
  35. ncbi request reprint Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues...
  36. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
    ..The objective of this study was to assess the impact of epidural analgesia (EA) and caesarean delivery (CD) on the risk of post-partum relapses and disability in women with MS...
  37. doi request reprint Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis
    Paola Valsasina
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    Hum Brain Mapp 33:2072-80. 2012
    ....
  38. doi request reprint Compensatory movement-related recruitment in amyotrophic lateral sclerosis patients with dominant upper motor neuron signs: an EEG source analysis study
    Alberto Inuggi
    Dept of Clinical Neurophysiology, Neurology, Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Brain Res 1425:37-46. 2011
    ..The latter correlation might suggest that the slight motor weakness in those patients may at least partly depend from a UMN dysfunction that can be compensated by cortical recruitment...
  39. doi request reprint Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Eur J Neurosci 31:1273-80. 2010
    ..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions...
  40. doi request reprint A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 65:1223-30. 2008
    ..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity...
  41. doi request reprint Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 31:515-25. 2010
    ....
  42. ncbi request reprint Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  43. doi request reprint Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
    Mult Scler 17:702-7. 2011
    ....
  44. doi request reprint Mapping early changes of cortical motor output after subcortical stroke: a transcranial magnetic stimulation study
    Raffaella Chieffo
    Department of Neurology, Scientific Institute Hospital San Raffaele, Italy
    Brain Stimul 6:322-9. 2013
    ..Moreover, the absence of iMEPs and the normalization of motor cortical excitability at follow-up indicate that the UH primary motor area does not contribute to recovery...
  45. doi request reprint Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans
    Paola Brambilla
    Institute of Experimental Neurology and Department of Neurology, San Raffaele Scientific Institute, 20132 Milan, Italy
    Neurosci Lett 530:155-60. 2012
    ..18]. Moreover, the gene is highly expressed in the central nervous system, and it has been found to be associated with sporadic cases of amyotrophic lateral sclerosis which shares some feature with PrMS...
  46. pmc Urokinase plasminogen receptor and the fibrinolytic complex play a role in nerve repair after nerve crush in mice, and in human neuropathies
    Cristina Rivellini
    Institute of Experimental Neurology INSPE, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 7:e32059. 2012
    ..On the contrary, neuropathies with signs of active regeneration displayed higher fibrinolytic activity. Overall, our results suggest that enforced fibrinolysis may facilitate regeneration and outcome of peripheral neuropathies...
  47. doi request reprint Chronic motor axonal neuropathy
    Nilo Riva
    Department of Neurology, INSPE and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    J Peripher Nerv Syst 16:341-6. 2011
    ..The patient's clinical, immunological and pathological findings are consistent with a diagnosis of a chronic motor axonal neuropathy (CMAN), likely of immune-mediated origin...
  48. ncbi request reprint Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..We also investigated whether the extent of brain activations was correlated with WM structural pathology measured using diffusion tensor (DT) MRI...
  49. doi request reprint A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  50. doi request reprint Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonia Ceccarelli
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 16:39-44. 2010
    ..42; p = 0.02). In CIS patients, deep GM is not spared, suggesting that iron-related changes and neurodegeneration occurs early. The magnitude of such damage is only minor and not associated with an increased risk of evolution to CDMS...
  51. ncbi request reprint Short-term accrual of gray matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 24:1139-46. 2005
    ..These observations suggest that progressive NAGM damage might yet be an additional factor leading to the accumulation of disability in progressive MS...
  52. doi request reprint Cortical control of unilateral simple movement in healthy aging
    Alberto Inuggi
    Department of Clinical Neurophysiology, Neurology, Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurobiol Aging 32:524-38. 2011
    ..Movement duration resulted negatively correlated with pre-SMA activity, suggesting its involvement in movement termination...
  53. ncbi request reprint Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:2323-32. 2003
    ....
  54. doi request reprint Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up study
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1378-83. 2008
    ..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease...
  55. ncbi request reprint Motor evoked potentials in a mouse model of chronic multiple sclerosis
    Stefano Amadio
    Department of Neurology and Clinical Neurophysiology, San Raffaele Scientific Institute, Universita Vita e Salute, Milan, Italy
    Muscle Nerve 33:265-73. 2006
    ..These results demonstrate that cMEPs are a useful method for monitoring corticospinal tract function in chronic-progressive EAE, and provide insight into the pathological substrate of the condition...
  56. pmc The cortical signature of amyotrophic lateral sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 7:e42816. 2012
    ..Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression...
  57. doi request reprint Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis
    Maria A Rocca
    Department of Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurology 79:1449-57. 2012
    ..To this aim, we assessed, using resting-state (RS) fMRI, intrinsic FC and functional network connectivity (FNC) of brain large-scale neuronal networks from 85 patients with relapsing-remitting MS (RRMS) and 40 matched controls...
  58. doi request reprint Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
    ....
  59. doi request reprint Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI study
    Maria Assunta Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 256:470-82. 2009
    ....
  60. doi request reprint Comparative study of mitoxantrone efficacy profile in patients with relapsing-remitting and secondary progressive multiple sclerosis
    Federica Esposito
    Department of Neurology, Division of Neuroscience, Scientific Institute San Raffaele, Milan, Italy
    Mult Scler 16:1490-9. 2010
    ..Mitoxantrone (MTX) is an immunosuppressive drug approved for multiple sclerosis (MS) treatment...
  61. doi request reprint A 3-year diffusion tensor MRI study of grey matter damage progression during the earliest clinical stage of MS
    Marco Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1209-14. 2008
    ....
  62. ncbi request reprint Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    Paola Valsasina
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neuroimage 26:822-8. 2005
    ....
  63. doi request reprint Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study
    Paolo Preziosa
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Radiology 260:541-50. 2011
    ....
  64. ncbi request reprint A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 19:1770-7. 2003
    ..It also suggests that, in these patients, functional abilities are sustained by increased recruitment of highly specialized cortical areas...
  65. pmc Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    PLoS ONE 5:e10198. 2010
    ..The scheme applied during the learning phase influences the pattern of such structural changes...
  66. ncbi request reprint Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
    ..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex...
  67. ncbi request reprint Simple and complex movement-associated functional MRI changes in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 21:108-17. 2004
    ..Local synaptic reorganization, recruitment of parallel existing pathways, and reorganization of distant sites are all likely to contribute to the observed functional changes. Hum. Brain Mapping 21:106-115, 2004...
  68. ncbi request reprint A composite score to predict short-term disease activity in patients with relapsing-remitting MS
    Maria Pia Sormani
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Neurology 69:1230-5. 2007
    ..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term...
  69. doi request reprint Differential cerebellar functional interactions during an interference task across multiple sclerosis phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Department of Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy
    Radiology 265:864-73. 2012
    ..To determine whether modification of the connections between cerebellar and prefrontal areas might vary among multiple sclerosis (MS) phenotypes and might be associated with cognitive failure...
  70. ncbi request reprint Normal-appearing white and grey matter damage in MS. A volumetric and diffusion tensor MRI study at 3.0 Tesla
    Antonia Ceccarelli
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 254:513-8. 2007
    ..Although histopathology was not available, axonal and neuronal damage and consequent reactive glial proliferation are the most likely substrates of the changes observed...
  71. ncbi request reprint Secondary progressive multiple sclerosis: current knowledge and future challenges
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 5:343-54. 2006
    ....
  72. ncbi request reprint Effects of glatiramer acetate on relapse rate and accumulated disability in multiple sclerosis: meta-analysis of three double-blind, randomized, placebo-controlled clinical trials
    Filippo Martinelli Boneschi
    Department of Neuroscience, Scientific Institute, University H San Raffaele, Milan, Italy
    Mult Scler 9:349-55. 2003
    ..It also suggests that GA efficacy is not significantly influenced by the patients' clinical characteristics at the time of treatment initiation...
  73. doi request reprint Cognitive learning is associated with gray matter changes in healthy human individuals: a tensor-based morphometry study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 48:585-9. 2009
    ..This may have important implications for the development of rehabilitation strategies in patients with neurological diseases...
  74. ncbi request reprint Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype
    Elisabetta Pagani
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    AJNR Am J Neuroradiol 26:341-6. 2005
    ..Progressive brain atrophy is a well-known feature of multiple sclerosis (MS). We characterized the spatial evolution of atrophy in different MS phenotypes...
  75. doi request reprint Motor nerve biopsy: clinical usefulness and histopathological criteria
    Nilo Riva
    Department of Neurology, INSPE and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Ann Neurol 69:197-201. 2011
    ..At baseline, motor biopsy was performed; diagnostic confirmation was obtained by 2-year clinical follow-up. Our results support the usefulness of this diagnostic procedure for selected cases of MN and LMND...
  76. ncbi request reprint A widespread pattern of cortical activations in patients at presentation with clinically isolated symptoms is associated with evolution to definite multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 26:1136-9. 2005
    ..Our purpose was to assess whether different patterns of cortical recruitment are associated with the short-term evolution of definite multiple sclerosis (MS)...
  77. pmc Foot pad skin biopsy in mouse models of hereditary neuropathy
    Patrizia Dacci
    Department of Neurology, Division of Neuroscience and INSPE, Neuropathology Unit, Milan, Italy
    Glia 58:2005-16. 2010
    ..Our data indicate that SB may reveal distal axonal pathology in mouse models and permits sequential follow-up of the neuropathy in an individual mouse, thereby reducing the number of mice necessary to document pathology of the PNS...
  78. doi request reprint A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 42:315-22. 2008
    ....
  79. ncbi request reprint Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis
    Federica Agosta
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2620-7. 2006
    ..This study also suggests that GM damage is one of the key factors associated with disability accumulation in this 'white matter' condition...
  80. ncbi request reprint Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
    ....
  81. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  82. doi request reprint Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  83. ncbi request reprint Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice
    F Ruffini
    Neuroimmunology Unit, Department of Neuroscience, DIBIT-San Raffaele Scientific Institute, Milano, Italy
    Gene Ther 8:1207-13. 2001
    ....
  84. ncbi request reprint Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice
    R Furlan
    Neuroimmunology Unit, Department of Neuroscience, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Gene Ther 8:13-9. 2001
    ....
  85. ncbi request reprint Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  86. doi request reprint Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
    Neurology 75:1134-40. 2010
    ..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation...
  87. ncbi request reprint In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  88. ncbi request reprint Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement--EEG evidence
    L Leocani
    Department of Neurophysiology, Scientific Institute H. San Raffaele, Milan, Italy
    Neuroimage 13:1186-92. 2001
    ....
  89. pmc Dominant LMNA mutations can cause combined muscular dystrophy and peripheral neuropathy
    S Benedetti
    Laboratory of Clinical Molecular Biology, Diagnostica e Ricerca San Raffaele, Milano, Italy
    J Neurol Neurosurg Psychiatry 76:1019-21. 2005
    ..Our observations further support the marked intrafamilial and interfamilial phenotypic heterogeneity associated with lamin A/C defects...
  90. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  91. doi request reprint Default-mode network dysfunction and cognitive impairment in progressive MS
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 74:1252-9. 2010
    ....
  92. ncbi request reprint Evidence for progressive gray matter loss in patients with relapsing-remitting MS
    P Valsasina
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 65:1126-8. 2005
    ..Time-trend analysis revealed a decrease of gray matter volumes over the study period (p < 0.001). This study shows that gray matter damage in relapsing-remitting MS evolves markedly over a short period of observation...
  93. doi request reprint Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss
    E Brini
    Neuroimmunology Unit INSpe, Milan, Italy
    J Neuroimmunol 209:33-9. 2009
    ..These results suggest that the therapeutic mechanism of P8A-CCL2 may rely on interference with immune cell recruitment...
  94. ncbi request reprint The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    M Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 60:853-60. 2003
    ..Magnetization transfer (MT) MRI can provide in vivo markers reflecting the severity of irreversible, MS-related brain damage occurring within and outside T2-visible lesions...
  95. doi request reprint IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis
    E Butti
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Gene Ther 15:504-15. 2008
    ..CSF delivery of HD-Ad vectors expressing anti-inflammatory molecules might represent a valuable therapeutic option for CNS inflammatory disorders...
  96. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  97. ncbi request reprint Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  98. ncbi request reprint Short-term correlations between clinical and MR imaging findings in relapsing-remitting multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 24:75-81. 2003
    ..Using data from the European/Canadian glatiramer acetate (GA) trial, we investigated short-term correlations between clinical and MR measures of disease activity in patients with relapsing-remitting MS (RRMS)...
  99. ncbi request reprint From inflammation to degeneration: the lessons of clinical trials
    G Comi
    Department of Neurology, Università Vita Salute IRCCS S Raffaele, Milan, Italy
    Neurol Sci 24:S295-7. 2003
    ..From the practical point of view, early treatment is mandatory...
  100. ncbi request reprint Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis
    M P Sormani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 62:1432-4. 2004
    ..As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients...
  101. doi request reprint Cognitive and psychosocial features of childhood and juvenile MS
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 70:1891-7. 2008
    ..To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases...