Giancarlo Comi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
  2. ncbi MS treatment: new perspectives
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Universita Vita Salute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Clin Neurol Neurosurg 108:339-45. 2006
  3. ncbi Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis
    Giancarlo Comi
    University Vita Salute San Raffaele, Department of Neurology and Institute of Experimental Neurology, Via Olgettina 60, 20132 Milan, Italy
    Expert Opin Pharmacother 14:123-36. 2013
  4. ncbi Computational classifiers for predicting the short-term course of Multiple sclerosis
    Bartolome Bejarano
    Department of Neuroscience, CIMA University of Navarra, Pamplona, Spain
    BMC Neurol 11:67. 2011
  5. ncbi [In-vivo assessment of multiple sclerosis pathology: the role of neuroimaging techniques]
    G Comi
    Centro de Esclerosis Múltiple, Instituto Científico San Rafael, Milan, Italia
    Rev Neurol 30:1218-23. 2000
  6. ncbi Phase III dose-comparison study of glatiramer acetate for multiple sclerosis
    Giancarlo Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Ann Neurol 69:75-82. 2011
  7. ncbi Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
    G Comi
    Department of Neurology, Universita Vita Salute San Raffaele, Milan, Italy
    Mult Scler 16:197-207. 2010
  8. ncbi A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy
    Giancarlo Comi
    Department of Neurology, Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 249:1370-7. 2002
  9. ncbi Clinically isolated syndrome: the rationale for early treatment
    Giancarlo Comi
    Department of Neurology, Vita-Salute San Raffaele University, Milan, Italy
    Nat Clin Pract Neurol 4:234-5. 2008
  10. ncbi European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Gla
    G Comi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Ann Neurol 49:290-7. 2001

Detail Information

Publications190 found, 100 shown here

  1. ncbi Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
    ....
  2. ncbi MS treatment: new perspectives
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Universita Vita Salute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Clin Neurol Neurosurg 108:339-45. 2006
    ..Such an approach is now tested in phase II-III clinical trials...
  3. ncbi Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis
    Giancarlo Comi
    University Vita Salute San Raffaele, Department of Neurology and Institute of Experimental Neurology, Via Olgettina 60, 20132 Milan, Italy
    Expert Opin Pharmacother 14:123-36. 2013
    ..The experience gained will benefit other research efforts to address the outstanding unmet treatment needs of patients with relapsing MS...
  4. ncbi Computational classifiers for predicting the short-term course of Multiple sclerosis
    Bartolome Bejarano
    Department of Neuroscience, CIMA University of Navarra, Pamplona, Spain
    BMC Neurol 11:67. 2011
    ..The aim of this study was to assess the diagnostic accuracy (sensitivity and specificity) of clinical, imaging and motor evoked potentials (MEP) for predicting the short-term prognosis of multiple sclerosis (MS)...
  5. ncbi [In-vivo assessment of multiple sclerosis pathology: the role of neuroimaging techniques]
    G Comi
    Centro de Esclerosis Múltiple, Instituto Científico San Rafael, Milan, Italia
    Rev Neurol 30:1218-23. 2000
    ....
  6. ncbi Phase III dose-comparison study of glatiramer acetate for multiple sclerosis
    Giancarlo Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Ann Neurol 69:75-82. 2011
    ..To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg compared to a 20mg dose...
  7. ncbi Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
    G Comi
    Department of Neurology, Universita Vita Salute San Raffaele, Milan, Italy
    Mult Scler 16:197-207. 2010
    ..The efficacy and safety of oral fingolimod are being further evaluated in a large phase III MS study programme...
  8. ncbi A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy
    Giancarlo Comi
    Department of Neurology, Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 249:1370-7. 2002
    ..Two serious adverse events occurred during the trial, both during placebo treatment. In conclusion the trial showed some short-term benefit of IVIg in about half of the patients confirming previous observation...
  9. ncbi Clinically isolated syndrome: the rationale for early treatment
    Giancarlo Comi
    Department of Neurology, Vita-Salute San Raffaele University, Milan, Italy
    Nat Clin Pract Neurol 4:234-5. 2008
  10. ncbi European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Gla
    G Comi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Ann Neurol 49:290-7. 2001
    ..003). The relapse rate was also significantly reduced by 33% for GA-treated patients (p = 0.012). All effects increased over time. Glatiramer acetate significantly reduced MRI-measured disease activity and burden...
  11. ncbi Physiopathology and treatment of fatigue in multiple sclerosis
    G Comi
    University of Milan, Department of Neuroscience, Scientific Institute H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 248:174-9. 2001
    ..No specific treatments are available. Management strategies include medications, exercise, and behavioural therapy; in most cases a combined approach is appropriate...
  12. ncbi Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
    G Comi
    Multiple Sclerosis Centre, Department of Neuroscience, IRCCS Ospedale S Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Lancet 357:1576-82. 2001
    ..We assessed the effect of interferon beta-1a on the occurrence of relapses in patients after first presentation with neurological events, who are at high risk of conversion to clinically definite multiple sclerosis...
  13. ncbi Optimisation of immunomodulatory therapies
    G Comi
    Department of Neurology and Clinical Neurophysiology, Via Olgettina 60, I-20132 Milan, Italy
    Neurol Sci 26:S15-7. 2005
  14. ncbi [Rationale for an early treatment of multiple sclerosis]
    G Comi
    Centro de Esclerosis Múltiple, Instituto Científico San Rafael, Milan, Italia
    Rev Neurol 30:1265-8. 2000
    ..However we must wait for the results of ongoing clinical trials to define if such an early treatment has substantial advantages compared to late treatment...
  15. ncbi Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Lancet 371:2085-92. 2008
    ..We assessed the effect of oral daily 0.3 and 0.6 mg laquinimod on MRI-monitored disease activity in a 36-week double-blind, placebo-controlled phase IIb study...
  16. ncbi Review neuroimaging in amyotrophic lateral sclerosis
    G Comi
    Department of Neurophysiopathology, Scientific Institute Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Eur J Neurol 6:629-37. 1999
    ....
  17. ncbi Clinical trials in multiple sclerosis: methodological issues
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Milan, Italy
    Curr Opin Neurol 18:245-52. 2005
    ....
  18. ncbi Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Lancet 374:1503-11. 2009
    ..We assessed the efficacy of early treatment with glatiramer acetate in delaying onset of clinically definite multiple sclerosis...
  19. ncbi Is it clinically relevant to repair focal multiple sclerosis lesions?
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute S Raffaele, Via Olgettina 48, 20132 Milan, Italy
    J Neurol Sci 265:17-20. 2008
    ..These recent modifications on our views of the MS pathogenesis and pathophysiology do have major implications on the therapeutic strategies, including the use of treatments aiming to enhance the recovery, such as stem cell therapy...
  20. ncbi Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial
    Giancarlo Comi
    Department of Neurology, Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 11:33-41. 2012
    ..We investigated the effects of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event...
  21. ncbi Definition of responder: introduction
    Giancarlo Comi
    Department of Neurology and Institute of Experimental Neurology, Università Vita Salute S Raffaele, Via Olgettina 48, 20132, Milano, Italy
    Neurol Sci 29:S209-10. 2008
    ..Different clinical and magnetic resonance imaging (MRI) parameters have been proposed. Measures of disease activity, attacks and active MRI lesions, are ore suitable, particularly in the remitting phase of the disease...
  22. ncbi Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. BMT-MS Study Group
    G Comi
    Multiple Sclerosis Centre, San Raffaele Scientific Institute, Milan, Italy
    J Neurol 247:376-82. 2000
    ..The consensus reached during the meeting and the design of the clinical trial are summarized in this contribution...
  23. ncbi Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
    ....
  24. ncbi A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
    ..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology...
  25. ncbi Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Then bilateral activation of these regions is seen, and late in the disease course, areas that healthy people recruit to do novel or complex tasks are activated...
  26. ncbi Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2844-51. 2009
    ....
  27. ncbi Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  28. ncbi Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
    ..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS...
  29. ncbi Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Maria A Rocca
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 18:847-55. 2003
    ..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage...
  30. ncbi Brain macro- and microscopic damage in patients with paediatric MS
    Martina Absinta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:1357-62. 2010
    ....
  31. ncbi fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  32. ncbi A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...
  33. ncbi Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  34. ncbi Persistent inflammation alters the function of the endogenous brain stem cell compartment
    Stefano Pluchino
    Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Brain 131:2564-78. 2008
    ....
  35. ncbi Motor area localization using fMRI-constrained cortical current density reconstruction of movement-related cortical potentials, a comparison with fMRI and TMS mapping
    Alberto Inuggi
    Department of Neurology, Neurophysiology and Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Milan, Italy
    Brain Res 1308:68-78. 2010
    ..This study confirms the usefulness of multimodal integration of fMRI, EEG and TMS in localizing M1 and the possibility to increase EEG spatial resolution using fMRI information...
  36. ncbi Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  37. ncbi Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis
    Luca Muzio
    Neuroimmunology Unit, DIBIT 2, Institute of Experimental Neurology INSPE, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milano, Italy
    Mol Cell Neurosci 43:268-80. 2010
    ..Finally, we show, by RT-PCR and in situ hybridization, that Cxcl10 is expressed also in the healthy human SvZ, suggesting a possible molecular parallelism between multiple sclerosis and EAE...
  38. ncbi The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
    ..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status...
  39. ncbi A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 65:1223-30. 2008
    ..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity...
  40. ncbi Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 31:515-25. 2010
    ....
  41. ncbi Impaired short-term motor learning in multiple sclerosis: evidence from virtual reality
    Letizia Leocani
    Department of Neurology, Clinical Neurophysiology and Neurorehabilitation, University Vita Salute, Scientific Institute Hospital San Raffaele, Milan, Italy
    Neurorehabil Neural Repair 21:273-8. 2007
    ..The objective of this study was to investigate the usefulness of VR in the assessment of short-term motor learning in multiple sclerosis (MS)...
  42. ncbi Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Ann Neurol 66:343-54. 2009
    ....
  43. ncbi Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
    Gianna Riccitelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 32:1535-43. 2011
    ..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype...
  44. ncbi Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:898-902. 2005
    ....
  45. ncbi Thalamic damage and long-term progression of disability in multiple sclerosis
    Maria Assunta Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 257:463-9. 2010
    ....
  46. ncbi Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:803-8. 2005
    ....
  47. ncbi Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis
    Paola Valsasina
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    Hum Brain Mapp 33:2072-80. 2012
    ....
  48. ncbi Compensatory movement-related recruitment in amyotrophic lateral sclerosis patients with dominant upper motor neuron signs: an EEG source analysis study
    Alberto Inuggi
    Dept of Clinical Neurophysiology, Neurology, Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Brain Res 1425:37-46. 2011
    ..The latter correlation might suggest that the slight motor weakness in those patients may at least partly depend from a UMN dysfunction that can be compensated by cortical recruitment...
  49. ncbi Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Eur J Neurosci 31:1273-80. 2010
    ..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions...
  50. ncbi Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
    Mult Scler 17:702-7. 2011
    ....
  51. ncbi Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  52. ncbi Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans
    Paola Brambilla
    Institute of Experimental Neurology and Department of Neurology, San Raffaele Scientific Institute, 20132 Milan, Italy
    Neurosci Lett 530:155-60. 2012
    ..18]. Moreover, the gene is highly expressed in the central nervous system, and it has been found to be associated with sporadic cases of amyotrophic lateral sclerosis which shares some feature with PrMS...
  53. ncbi Urokinase plasminogen receptor and the fibrinolytic complex play a role in nerve repair after nerve crush in mice, and in human neuropathies
    Cristina Rivellini
    Institute of Experimental Neurology INSPE, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 7:e32059. 2012
    ..On the contrary, neuropathies with signs of active regeneration displayed higher fibrinolytic activity. Overall, our results suggest that enforced fibrinolysis may facilitate regeneration and outcome of peripheral neuropathies...
  54. ncbi Chronic motor axonal neuropathy
    Nilo Riva
    Department of Neurology, INSPE and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    J Peripher Nerv Syst 16:341-6. 2011
    ..The patient's clinical, immunological and pathological findings are consistent with a diagnosis of a chronic motor axonal neuropathy (CMAN), likely of immune-mediated origin...
  55. ncbi Short-term accrual of gray matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 24:1139-46. 2005
    ..These observations suggest that progressive NAGM damage might yet be an additional factor leading to the accumulation of disability in progressive MS...
  56. ncbi Cortical control of unilateral simple movement in healthy aging
    Alberto Inuggi
    Department of Clinical Neurophysiology, Neurology, Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurobiol Aging 32:524-38. 2011
    ..Movement duration resulted negatively correlated with pre-SMA activity, suggesting its involvement in movement termination...
  57. ncbi A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  58. ncbi Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:2323-32. 2003
    ....
  59. ncbi Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..Such changes do not reflect a concomitant development of brain atrophy and confirm the importance of GM pathology in MS...
  60. ncbi Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonia Ceccarelli
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 16:39-44. 2010
    ..42; p = 0.02). In CIS patients, deep GM is not spared, suggesting that iron-related changes and neurodegeneration occurs early. The magnitude of such damage is only minor and not associated with an increased risk of evolution to CDMS...
  61. ncbi Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
    ....
  62. ncbi Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    Paola Valsasina
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neuroimage 26:822-8. 2005
    ....
  63. ncbi Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
    ..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex...
  64. ncbi A 3-year diffusion tensor MRI study of grey matter damage progression during the earliest clinical stage of MS
    Marco Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1209-14. 2008
    ....
  65. ncbi Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up study
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1378-83. 2008
    ..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease...
  66. ncbi Motor evoked potentials in a mouse model of chronic multiple sclerosis
    Stefano Amadio
    Department of Neurology and Clinical Neurophysiology, San Raffaele Scientific Institute, , Milan, Italy
    Muscle Nerve 33:265-73. 2006
    ..These results demonstrate that cMEPs are a useful method for monitoring corticospinal tract function in chronic-progressive EAE, and provide insight into the pathological substrate of the condition...
  67. ncbi Comparative study of mitoxantrone efficacy profile in patients with relapsing-remitting and secondary progressive multiple sclerosis
    Federica Esposito
    Department of Neurology, Division of Neuroscience, Scientific Institute San Raffaele, Milan, Italy
    Mult Scler 16:1490-9. 2010
    ..Mitoxantrone (MTX) is an immunosuppressive drug approved for multiple sclerosis (MS) treatment...
  68. ncbi A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 19:1770-7. 2003
    ..It also suggests that, in these patients, functional abilities are sustained by increased recruitment of highly specialized cortical areas...
  69. ncbi Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    PLoS ONE 5:e10198. 2010
    ..The scheme applied during the learning phase influences the pattern of such structural changes...
  70. ncbi Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI study
    Maria Assunta Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 256:470-82. 2009
    ....
  71. ncbi Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study
    Paolo Preziosa
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Radiology 260:541-50. 2011
    ....
  72. ncbi Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..80, P<0.001). CONCLUSIONS: This study suggests that functional cortical changes occur in patients with migraine and brain MRI abnormalities and that they might be secondary to the extent of subcortical structural damage...
  73. ncbi Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes
    R Furlan
    Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 167:1821-9. 2001
    ....
  74. ncbi In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  75. ncbi Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice
    R Furlan
    Neuroimmunology Unit, Department of Neuroscience, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Gene Ther 8:13-9. 2001
    ....
  76. ncbi Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice
    F Ruffini
    Neuroimmunology Unit, Department of Neuroscience, DIBIT-San Raffaele Scientific Institute, Milano, Italy
    Gene Ther 8:1207-13. 2001
    ....
  77. ncbi Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  78. ncbi Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  79. ncbi Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
    Neurology 75:1134-40. 2010
    ..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation...
  80. ncbi Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement--EEG evidence
    L Leocani
    Department of Neurophysiology, Scientific Institute H. San Raffaele, Milan, Italy
    Neuroimage 13:1186-92. 2001
    ....
  81. ncbi Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ....
  82. ncbi In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  83. ncbi Dominant LMNA mutations can cause combined muscular dystrophy and peripheral neuropathy
    S Benedetti
    Laboratory of Clinical Molecular Biology, Diagnostica e Ricerca San Raffaele, Milano, Italy
    J Neurol Neurosurg Psychiatry 76:1019-21. 2005
    ..Our observations further support the marked intrafamilial and interfamilial phenotypic heterogeneity associated with lamin A/C defects...
  84. ncbi Default-mode network dysfunction and cognitive impairment in progressive MS
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 74:1252-9. 2010
    ....
  85. ncbi A composite score to predict short-term disease activity in patients with relapsing-remitting MS
    Maria Pia Sormani
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Neurology 69:1230-5. 2007
    ..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term...
  86. ncbi Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism
    Stefano Pluchino
    Neuroimmunology Unit-DIBIT, Vita-Salute University, San Raffaele Hospital, Via Olgettina 58, 20132 Milan, Italy
    Nature 436:266-71. 2005
    ..These results indicate that undifferentiated adult NPCs have relevant therapeutic potential in chronic inflammatory CNS disorders because they display immune-like functions that promote long-lasting neuroprotection...
  87. ncbi Evidence for progressive gray matter loss in patients with relapsing-remitting MS
    P Valsasina
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 65:1126-8. 2005
    ..Time-trend analysis revealed a decrease of gray matter volumes over the study period (p < 0.001). This study shows that gray matter damage in relapsing-remitting MS evolves markedly over a short period of observation...
  88. ncbi Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss
    E Brini
    Neuroimmunology Unit INSpe, Milan, Italy
    J Neuroimmunol 209:33-9. 2009
    ..These results suggest that the therapeutic mechanism of P8A-CCL2 may rely on interference with immune cell recruitment...
  89. ncbi IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis
    E Butti
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Gene Ther 15:504-15. 2008
    ..CSF delivery of HD-Ad vectors expressing anti-inflammatory molecules might represent a valuable therapeutic option for CNS inflammatory disorders...
  90. ncbi Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  91. ncbi An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  92. ncbi The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    M Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 60:853-60. 2003
    ....
  93. ncbi Short-term correlations between clinical and MR imaging findings in relapsing-remitting multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 24:75-81. 2003
    ..Clinical and MR imaging assessment can provide complementary outcome measures for RRMS trials...
  94. ncbi Cognitive and psychosocial features of childhood and juvenile MS
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 70:1891-7. 2008
    ..To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases...
  95. ncbi The "mirror-neuron system" in MS: A 3 tesla fMRI study
    M A Rocca
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neurology 70:255-62. 2008
    ..We used functional MRI (fMRI) to investigate the properties of the MNS in patients with multiple sclerosis (MS)...
  96. ncbi Long-term follow-up of patients treated with glatiramer acetate: a multicentre, multinational extension of the European/Canadian double-blind, placebo-controlled, MRI-monitored trial
    M Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 13:502-8. 2007
    ..An earlier initiation of GA treatment in patients with active RRMS might, at least partially, have a favourable impact on long-term disease evolution...
  97. ncbi Functional MR imaging correlates of neuropsychological impairment in primary-progressive multiple sclerosis
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 31:1240-6. 2010
    ..Cognitive deficits affect <or=30% of patients with PPMS. We investigated the functional correlates of cognitive network dysfunction in patients with PPMS and their correlation with the extent of structural MR imaging damage...
  98. ncbi Preserved brain adaptive properties in patients with benign multiple sclerosis
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Neurology 74:142-9. 2010
    ....
  99. ncbi Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI
    F Agosta
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 64:631-5. 2005
    ..Such cord diffusivity changes in patients with PPMS are likely to reflect irreversible axonal injury and reactive gliosis and seem to be independent of brain damage...
  100. ncbi MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis
    P Tortorella
    Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol 253:903-7. 2006
    ..It also suggests that in these patients GM is spared by the disease process and that NAWM changes are likely to be secondary to Wallerian degeneration of fibers passing through macroscopic lesions...
  101. ncbi Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, 20132 Milan, Italy
    Neuroimage 15:559-67. 2002
    ..It also suggests that fMRI might be a valuable tool to monitor the efficacy of treatment aimed at reducing MS-related fatigue...