Giancarlo Comi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
  2. ncbi request reprint MS treatment: new perspectives
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Universita Vita Salute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Clin Neurol Neurosurg 108:339-45. 2006
  3. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
  4. doi request reprint Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis
    Giancarlo Comi
    University Vita Salute San Raffaele, Department of Neurology and Institute of Experimental Neurology, Via Olgettina 60, 20132 Milan, Italy
    Expert Opin Pharmacother 14:123-36. 2013
  5. pmc Computational classifiers for predicting the short-term course of Multiple sclerosis
    Bartolome Bejarano
    Department of Neuroscience, CIMA University of Navarra, Pamplona, Spain
    BMC Neurol 11:67. 2011
  6. ncbi request reprint Physiopathology and treatment of fatigue in multiple sclerosis
    G Comi
    University of Milan, Department of Neuroscience, Scientific Institute H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 248:174-9. 2001
  7. ncbi request reprint Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
    G Comi
    Multiple Sclerosis Centre, Department of Neuroscience, IRCCS Ospedale S Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Lancet 357:1576-82. 2001
  8. ncbi request reprint Is it clinically relevant to repair focal multiple sclerosis lesions?
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute S Raffaele, Via Olgettina 48, 20132 Milan, Italy
    J Neurol Sci 265:17-20. 2008
  9. ncbi request reprint Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial
    Giancarlo Comi
    Department of Neurology, Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 11:33-41. 2012
  10. ncbi request reprint Clinical trials in multiple sclerosis: methodological issues
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Milan, Italy
    Curr Opin Neurol 18:245-52. 2005

Detail Information

Publications200 found, 100 shown here

  1. ncbi request reprint Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
    ....
  2. ncbi request reprint MS treatment: new perspectives
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Universita Vita Salute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Clin Neurol Neurosurg 108:339-45. 2006
    ..Such an approach is now tested in phase II-III clinical trials...
  3. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
    ....
  4. doi request reprint Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis
    Giancarlo Comi
    University Vita Salute San Raffaele, Department of Neurology and Institute of Experimental Neurology, Via Olgettina 60, 20132 Milan, Italy
    Expert Opin Pharmacother 14:123-36. 2013
    ..It was anticipated that new approaches to treatment, including oral agents such as cladribine tablets, may improve adherence. In 2011, the development of cladribine tablets was stopped following negative feedback from the EMA and FDA...
  5. pmc Computational classifiers for predicting the short-term course of Multiple sclerosis
    Bartolome Bejarano
    Department of Neuroscience, CIMA University of Navarra, Pamplona, Spain
    BMC Neurol 11:67. 2011
    ..The aim of this study was to assess the diagnostic accuracy (sensitivity and specificity) of clinical, imaging and motor evoked potentials (MEP) for predicting the short-term prognosis of multiple sclerosis (MS)...
  6. ncbi request reprint Physiopathology and treatment of fatigue in multiple sclerosis
    G Comi
    University of Milan, Department of Neuroscience, Scientific Institute H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 248:174-9. 2001
    ..No specific treatments are available. Management strategies include medications, exercise, and behavioural therapy; in most cases a combined approach is appropriate...
  7. ncbi request reprint Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
    G Comi
    Multiple Sclerosis Centre, Department of Neuroscience, IRCCS Ospedale S Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Lancet 357:1576-82. 2001
    ..We assessed the effect of interferon beta-1a on the occurrence of relapses in patients after first presentation with neurological events, who are at high risk of conversion to clinically definite multiple sclerosis...
  8. ncbi request reprint Is it clinically relevant to repair focal multiple sclerosis lesions?
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute S Raffaele, Via Olgettina 48, 20132 Milan, Italy
    J Neurol Sci 265:17-20. 2008
    ..These recent modifications on our views of the MS pathogenesis and pathophysiology do have major implications on the therapeutic strategies, including the use of treatments aiming to enhance the recovery, such as stem cell therapy...
  9. ncbi request reprint Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial
    Giancarlo Comi
    Department of Neurology, Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 11:33-41. 2012
    ..We investigated the effects of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event...
  10. ncbi request reprint Clinical trials in multiple sclerosis: methodological issues
    Giancarlo Comi
    Department of Neurology and Clinical Neurophysiology, Milan, Italy
    Curr Opin Neurol 18:245-52. 2005
    ....
  11. doi request reprint Clinically isolated syndrome: the rationale for early treatment
    Giancarlo Comi
    Department of Neurology, Vita Salute San Raffaele University, Milan, Italy
    Nat Clin Pract Neurol 4:234-5. 2008
  12. ncbi request reprint Definition of responder: introduction
    Giancarlo Comi
    Department of Neurology and Institute of Experimental Neurology, Università Vita Salute S Raffaele, Via Olgettina 48, 20132, Milano, Italy
    Neurol Sci 29:S209-10. 2008
    ..Different clinical and magnetic resonance imaging (MRI) parameters have been proposed. Measures of disease activity, attacks and active MRI lesions, are ore suitable, particularly in the remitting phase of the disease...
  13. ncbi request reprint Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Lancet 371:2085-92. 2008
    ..We assessed the effect of oral daily 0.3 and 0.6 mg laquinimod on MRI-monitored disease activity in a 36-week double-blind, placebo-controlled phase IIb study...
  14. doi request reprint Phase III dose-comparison study of glatiramer acetate for multiple sclerosis
    Giancarlo Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Ann Neurol 69:75-82. 2011
    ..To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg compared to a 20mg dose...
  15. ncbi request reprint A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy
    Giancarlo Comi
    Department of Neurology, Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 249:1370-7. 2002
    ..Two serious adverse events occurred during the trial, both during placebo treatment. In conclusion the trial showed some short-term benefit of IVIg in about half of the patients confirming previous observation...
  16. doi request reprint Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
    G Comi
    Department of Neurology, Universita Vita Salute San Raffaele, Milan, Italy
    Mult Scler 16:197-207. 2010
    ..The efficacy and safety of oral fingolimod are being further evaluated in a large phase III MS study programme...
  17. ncbi request reprint Optimisation of immunomodulatory therapies
    G Comi
    Department of Neurology and Clinical Neurophysiology, Via Olgettina 60, I 20132 Milan, Italy
    Neurol Sci 26:S15-7. 2005
  18. ncbi request reprint European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Gla
    G Comi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Ann Neurol 49:290-7. 2001
    ..003). The relapse rate was also significantly reduced by 33% for GA-treated patients (p = 0.012). All effects increased over time. Glatiramer acetate significantly reduced MRI-measured disease activity and burden...
  19. ncbi request reprint Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Lancet 374:1503-11. 2009
    ..We assessed the efficacy of early treatment with glatiramer acetate in delaying onset of clinically definite multiple sclerosis...
  20. ncbi request reprint Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. BMT-MS Study Group
    G Comi
    Multiple Sclerosis Centre, San Raffaele Scientific Institute, Milan, Italy
    J Neurol 247:376-82. 2000
    ..The consensus reached during the meeting and the design of the clinical trial are summarized in this contribution...
  21. ncbi request reprint [Rationale for an early treatment of multiple sclerosis]
    G Comi
    Centro de Esclerosis Múltiple, Instituto Científico San Rafael, Milan, Italia
    Rev Neurol 30:1265-8. 2000
    ..However we must wait for the results of ongoing clinical trials to define if such an early treatment has substantial advantages compared to late treatment...
  22. ncbi request reprint [In-vivo assessment of multiple sclerosis pathology: the role of neuroimaging techniques]
    G Comi
    Centro de Esclerosis Múltiple, Instituto Científico San Rafael, Milan, Italia
    Rev Neurol 30:1218-23. 2000
    ....
  23. ncbi request reprint Review neuroimaging in amyotrophic lateral sclerosis
    G Comi
    Department of Neurophysiopathology, Scientific Institute Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Eur J Neurol 6:629-37. 1999
    ....
  24. ncbi request reprint Structural and functional MRI correlates of Stroop control in benign MS
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:276-90. 2009
    ....
  25. ncbi request reprint A multiparametric evaluation of regional brain damage in patients with primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:3009-19. 2009
    ..Combining regional measures derived from different MR modalities may be a valuable tool to improve our understanding of PPMS pathophysiology...
  26. ncbi request reprint Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Movement-associated cortical reorganisation is known to occur in multiple sclerosis (MS). We aimed to define the development of such cortical reorganisation by comparing data from patients with different disease phenotypes...
  27. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  28. doi request reprint Corpus callosum damage and cognitive dysfunction in benign MS
    Sarlota Mesaros
    Scientific Institute, University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2656-66. 2009
    ..MRI assessment of topographical distribution of tissue damage may represent a rewarding strategy for understanding the subtle clinical deficits of patients with BMS...
  29. ncbi request reprint Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 30:2844-51. 2009
    ....
  30. doi request reprint White matter microstructural damage in Alzheimer's disease at different ages of onset
    Elisa Canu
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurobiol Aging 34:2331-40. 2013
    ..In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups. ..
  31. ncbi request reprint The topography of brain damage at different stages of Parkinson's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Hum Brain Mapp 34:2798-807. 2013
    ..WM abnormalities beyond the nigrostriatal system accumulate with increasing PD severity. WM damage is likely to contribute to the more severe motor and nonmotor dysfunctions occurring in patients at the later stages...
  32. ncbi request reprint A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...
  33. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  34. ncbi request reprint Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
    Maria A Rocca
    Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 18:847-55. 2003
    ..This suggests that the increased functional recruitment of the cortex in these patients might have an adaptive role in limiting the clinical impact of irreversible tissue damage...
  35. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  36. ncbi request reprint Brain macro- and microscopic damage in patients with paediatric MS
    Martina Absinta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    J Neurol Neurosurg Psychiatry 81:1357-62. 2010
    ....
  37. ncbi request reprint The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 39:1499-509. 2008
    ..The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status...
  38. ncbi request reprint Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  39. pmc Persistent inflammation alters the function of the endogenous brain stem cell compartment
    Stefano Pluchino
    Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Brain 131:2564-78. 2008
    ....
  40. doi request reprint Motor area localization using fMRI-constrained cortical current density reconstruction of movement-related cortical potentials, a comparison with fMRI and TMS mapping
    Alberto Inuggi
    Department of Neurology, Neurophysiology and Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Milan, Italy
    Brain Res 1308:68-78. 2010
    ..This study confirms the usefulness of multimodal integration of fMRI, EEG and TMS in localizing M1 and the possibility to increase EEG spatial resolution using fMRI information...
  41. ncbi request reprint Deep repetitive transcranial magnetic stimulation with H-coil on lower limb motor function in chronic stroke: a pilot study
    Raffaella Chieffo
    Scientific Institute Vita Salute University San Raffaele, Neurological Department, Experimental Neurophysiology Unit, INSPE Institute of Experimental Neurology, Milan, Italy
    Arch Phys Med Rehabil 95:1141-7. 2014
    ..To assess the efficacy of high-frequency (20 Hz) brain stimulation on lower limb motor function in subjects with chronic (> 6 mo) subcortical stroke...
  42. doi request reprint Response competition and response inhibition during different choice-discrimination tasks: evidence from ERP measured inside MRI scanner
    Javier J Gonzalez-Rosa
    Institute of Experimental Neurology and Neurological Dept, San Raffaele Scientific Institute, Milan, Italy
    Int J Psychophysiol 89:37-47. 2013
    ..LN, however, appears to be related to higher level conflict monitoring associated with response choice-discrimination but not when the presence of cognitive conflict is associated with response inhibition. ..
  43. doi request reprint Gray matter damage predicts the accumulation of disability 13 years later in MS
    Massimo Filippi
    From the Neuroimaging Research Unit M F, P P, G R, M A R, Institute of Experimental Neurology, and Department of Neurology M F, P P, V M, G C, M A R, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan Biostatistics Unit M C, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy and Medical Physics Group M A H, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, UK
    Neurology 81:1759-67. 2013
    ....
  44. ncbi request reprint Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:898-902. 2005
    ..Proton magnetic resonance spectroscopy (1H-MRS) can be used to measure in vivo whole-brain N-acetylaspartate (WBNAA) concentrations, the decrease of whose levels is considered a marker of neuronal-axonal injury...
  45. ncbi request reprint Diffusion-tensor magnetic resonance imaging detects normal-appearing white matter damage unrelated to short-term disease activity in patients at the earliest clinical stage of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Arch Neurol 62:803-8. 2005
    ..Diffusion-tensor (DT) magnetic resonance imaging (MRI) has the potential to elucidate some characteristics of tissue microstructure inaccessible to other MRI techniques...
  46. doi request reprint Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    Hum Brain Mapp 31:515-25. 2010
    ....
  47. doi request reprint Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
    Gianna Riccitelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 32:1535-43. 2011
    ..To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2-visible lesion distribution according to the clinical phenotype...
  48. doi request reprint Thalamic damage and long-term progression of disability in multiple sclerosis
    Maria Assunta Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 257:463-9. 2010
    ....
  49. ncbi request reprint Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Ann Neurol 66:343-54. 2009
    ....
  50. ncbi request reprint Impaired short-term motor learning in multiple sclerosis: evidence from virtual reality
    Letizia Leocani
    Department of Neurology, Clinical Neurophysiology and Neurorehabilitation, University Vita Salute, Scientific Institute Hospital San Raffaele, Milan, Italy
    Neurorehabil Neural Repair 21:273-8. 2007
    ..The objective of this study was to investigate the usefulness of VR in the assessment of short-term motor learning in multiple sclerosis (MS)...
  51. doi request reprint Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis
    Luca Muzio
    Neuroimmunology Unit, DIBIT 2, Institute of Experimental Neurology INSPE, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milano, Italy
    Mol Cell Neurosci 43:268-80. 2010
    ..Finally, we show, by RT-PCR and in situ hybridization, that Cxcl10 is expressed also in the healthy human SvZ, suggesting a possible molecular parallelism between multiple sclerosis and EAE...
  52. ncbi request reprint A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 65:1223-30. 2008
    ..Evidence is accumulating that indicates that a selected assessment of gray matter (GM) damage is able to provide strong paraclinical correlates of multiple sclerosis (MS) severity...
  53. ncbi request reprint Functional network connectivity in the behavioral variant of frontotemporal dementia
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy Electronic address
    Cortex 49:2389-401. 2013
    ....
  54. ncbi request reprint Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues...
  55. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
    ..The objective of this study was to assess the impact of epidural analgesia (EA) and caesarean delivery (CD) on the risk of post-partum relapses and disability in women with MS...
  56. doi request reprint Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis
    Paola Valsasina
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy
    Hum Brain Mapp 33:2072-80. 2012
    ....
  57. doi request reprint Compensatory movement-related recruitment in amyotrophic lateral sclerosis patients with dominant upper motor neuron signs: an EEG source analysis study
    Alberto Inuggi
    Dept of Clinical Neurophysiology, Neurology, Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Brain Res 1425:37-46. 2011
    ..The latter correlation might suggest that the slight motor weakness in those patients may at least partly depend from a UMN dysfunction that can be compensated by cortical recruitment...
  58. ncbi request reprint Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Eur J Neurosci 31:1273-80. 2010
    ..Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions...
  59. ncbi request reprint Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  60. doi request reprint Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis
    Antonia Ceccarelli
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy
    Mult Scler 17:702-7. 2011
    ....
  61. doi request reprint Mapping early changes of cortical motor output after subcortical stroke: a transcranial magnetic stimulation study
    Raffaella Chieffo
    Department of Neurology, Scientific Institute Hospital San Raffaele, Italy
    Brain Stimul 6:322-9. 2013
    ..Moreover, the absence of iMEPs and the normalization of motor cortical excitability at follow-up indicate that the UH primary motor area does not contribute to recovery...
  62. ncbi request reprint Selective decreased grey matter volume of the pain-matrix network in cluster headache
    Martina Absinta
    Vita Salute San Raffaele University, Italy
    Cephalalgia 32:109-15. 2012
    ..We assessed the pattern of regional white matter and grey matter abnormalities in patients with cluster headache (CH), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM)...
  63. doi request reprint Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans
    Paola Brambilla
    Institute of Experimental Neurology and Department of Neurology, San Raffaele Scientific Institute, 20132 Milan, Italy
    Neurosci Lett 530:155-60. 2012
    ..18]. Moreover, the gene is highly expressed in the central nervous system, and it has been found to be associated with sporadic cases of amyotrophic lateral sclerosis which shares some feature with PrMS...
  64. pmc Urokinase plasminogen receptor and the fibrinolytic complex play a role in nerve repair after nerve crush in mice, and in human neuropathies
    Cristina Rivellini
    Institute of Experimental Neurology INSPE, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 7:e32059. 2012
    ..On the contrary, neuropathies with signs of active regeneration displayed higher fibrinolytic activity. Overall, our results suggest that enforced fibrinolysis may facilitate regeneration and outcome of peripheral neuropathies...
  65. doi request reprint Chronic motor axonal neuropathy
    Nilo Riva
    Department of Neurology, INSPE and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    J Peripher Nerv Syst 16:341-6. 2011
    ..The patient's clinical, immunological and pathological findings are consistent with a diagnosis of a chronic motor axonal neuropathy (CMAN), likely of immune-mediated origin...
  66. doi request reprint Cortical control of unilateral simple movement in healthy aging
    Alberto Inuggi
    Department of Clinical Neurophysiology, Neurology, Neurorehabilitation, Experimental Neurology Institute, IRCCS San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurobiol Aging 32:524-38. 2011
    ..Movement duration resulted negatively correlated with pre-SMA activity, suggesting its involvement in movement termination...
  67. doi request reprint A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  68. ncbi request reprint Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:2323-32. 2003
    ....
  69. ncbi request reprint Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonia Ceccarelli
    Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 16:39-44. 2010
    ..42; p = 0.02). In CIS patients, deep GM is not spared, suggesting that iron-related changes and neurodegeneration occurs early. The magnitude of such damage is only minor and not associated with an increased risk of evolution to CDMS...
  70. ncbi request reprint Short-term accrual of gray matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI
    Marco Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 24:1139-46. 2005
    ..These observations suggest that progressive NAGM damage might yet be an additional factor leading to the accumulation of disability in progressive MS...
  71. doi request reprint Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, Division of Neuroscience, and Scientific Institute and Vita Salute University, Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 262:932-40. 2012
    ....
  72. ncbi request reprint Motor evoked potentials in a mouse model of chronic multiple sclerosis
    Stefano Amadio
    Department of Neurology and Clinical Neurophysiology, San Raffaele Scientific Institute, Universita Vita e Salute, Milan, Italy
    Muscle Nerve 33:265-73. 2006
    ..These results demonstrate that cMEPs are a useful method for monitoring corticospinal tract function in chronic-progressive EAE, and provide insight into the pathological substrate of the condition...
  73. doi request reprint A 3-year diffusion tensor MRI study of grey matter damage progression during the earliest clinical stage of MS
    Marco Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1209-14. 2008
    ....
  74. ncbi request reprint Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    Paola Valsasina
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neuroimage 26:822-8. 2005
    ....
  75. ncbi request reprint Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS. A large scale, short-term follow-up study
    Sarlota Mesaros
    Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 255:1378-83. 2008
    ..These data confirm the need to develop clinical and MRI measures more sensitive towards the more disabling aspects of the disease...
  76. ncbi request reprint Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration
    Massimo Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 18:558-63. 2003
    ..This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex...
  77. doi request reprint Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: a voxelwise diffusion-tensor MR study
    Paolo Preziosa
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Radiology 260:541-50. 2011
    ....
  78. ncbi request reprint A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 19:1770-7. 2003
    ..It also suggests that, in these patients, functional abilities are sustained by increased recruitment of highly specialized cortical areas...
  79. doi request reprint Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue. A kinematic and functional MRI study
    Maria Assunta Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 256:470-82. 2009
    ....
  80. doi request reprint Comparative study of mitoxantrone efficacy profile in patients with relapsing-remitting and secondary progressive multiple sclerosis
    Federica Esposito
    Department of Neurology, Division of Neuroscience, Scientific Institute San Raffaele, Milan, Italy
    Mult Scler 16:1490-9. 2010
    ..Mitoxantrone (MTX) is an immunosuppressive drug approved for multiple sclerosis (MS) treatment...
  81. pmc Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study
    Massimo Filippi
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    PLoS ONE 5:e10198. 2010
    ..The scheme applied during the learning phase influences the pattern of such structural changes...
  82. ncbi request reprint Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..We also investigated whether the extent of brain activations was correlated with WM structural pathology measured using diffusion tensor (DT) MRI...
  83. ncbi request reprint Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes
    R Furlan
    Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 167:1821-9. 2001
    ....
  84. doi request reprint In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis
    B Benedetti
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Mult Scler 15:789-94. 2009
    ....
  85. doi request reprint Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  86. ncbi request reprint Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice
    F Ruffini
    Neuroimmunology Unit, Department of Neuroscience, DIBIT-San Raffaele Scientific Institute, Milano, Italy
    Gene Ther 8:1207-13. 2001
    ....
  87. ncbi request reprint Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice
    R Furlan
    Neuroimmunology Unit, Department of Neuroscience, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Gene Ther 8:13-9. 2001
    ....
  88. doi request reprint Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
    Neurology 75:1134-40. 2010
    ..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation...
  89. ncbi request reprint Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement--EEG evidence
    L Leocani
    Department of Neurophysiology, Scientific Institute H. San Raffaele, Milan, Italy
    Neuroimage 13:1186-92. 2001
    ....
  90. doi request reprint Default-mode network dysfunction and cognitive impairment in progressive MS
    M A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 74:1252-9. 2010
    ....
  91. ncbi request reprint Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  92. ncbi request reprint In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  93. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  94. pmc Dominant LMNA mutations can cause combined muscular dystrophy and peripheral neuropathy
    S Benedetti
    Laboratory of Clinical Molecular Biology, Diagnostica e Ricerca San Raffaele, Milano, Italy
    J Neurol Neurosurg Psychiatry 76:1019-21. 2005
    ..Our observations further support the marked intrafamilial and interfamilial phenotypic heterogeneity associated with lamin A/C defects...
  95. ncbi request reprint A composite score to predict short-term disease activity in patients with relapsing-remitting MS
    Maria Pia Sormani
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Neurology 69:1230-5. 2007
    ..To generate and validate a composite (clinical and MRI-based) score able to identify individual patients with relapsing-remitting multiple sclerosis (RRMS) with a high risk of experiencing relapses in the short term...
  96. ncbi request reprint Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism
    Stefano Pluchino
    Neuroimmunology Unit DIBIT, Vita Salute University, San Raffaele Hospital, Via Olgettina 58, 20132 Milan, Italy
    Nature 436:266-71. 2005
    ..These results indicate that undifferentiated adult NPCs have relevant therapeutic potential in chronic inflammatory CNS disorders because they display immune-like functions that promote long-lasting neuroprotection...
  97. doi request reprint IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis
    E Butti
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Gene Ther 15:504-15. 2008
    ..CSF delivery of HD-Ad vectors expressing anti-inflammatory molecules might represent a valuable therapeutic option for CNS inflammatory disorders...
  98. ncbi request reprint Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2628-34. 2006
    ..These data may be relevant to select patients for future exploratory phase II trials...
  99. doi request reprint Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss
    E Brini
    Neuroimmunology Unit INSpe, Milan, Italy
    J Neuroimmunol 209:33-9. 2009
    ..These results suggest that the therapeutic mechanism of P8A-CCL2 may rely on interference with immune cell recruitment...
  100. ncbi request reprint The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    M Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 60:853-60. 2003
    ..Magnetization transfer (MT) MRI can provide in vivo markers reflecting the severity of irreversible, MS-related brain damage occurring within and outside T2-visible lesions...
  101. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...