Bruno Colombo

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
  2. doi request reprint Headache therapy with neuronal stabilising drugs
    Bruno Colombo
    Department of Neurology Headache Research Unit, IRCCS San Raffaele University Vita Salute, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 29:S131-6. 2008
  3. ncbi request reprint Therapy of primary headaches: the role of antidepressants
    B Colombo
    Department of Neurology, Scientific Institute, Ospedale San Raffaele Headache Research Unit, Via Olgettina 48, Milan, Italy
    Neurol Sci 25:S171-5. 2004
  4. ncbi request reprint Riboflavin and migraine: the bridge over troubled mitochondria
    Bruno Colombo
    Headache Unit, Department of Neurology, San Raffaele Hospital, University Vita Salute, Via Olgettina 48, 20132, Milan, Italy
    Neurol Sci 35:141-4. 2014
  5. doi request reprint Refractory migraine: the role of the physician in assessment and treatment of a problematic disease
    Bruno Colombo
    Department of Neurology, Headache Center and Institute of Experimental Neurology, IRCCS San Raffaele Hospital, Vita Salute University, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 34:S109-12. 2013
  6. doi request reprint From neuroimaging to clinical setting: what have we learned from migraine pain?
    Bruno Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Vita Salute University, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 33:S95-7. 2012
  7. doi request reprint Ocular pain: a neurological perspective
    Bruno Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Via Olgettina 48, 20132, Milan, Italy
    Neurol Sci 31:S103-5. 2010
  8. ncbi request reprint Medications for neuropathic pain: current trends
    B Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Via Olgettina 48, I 20132, Milan, Italy
    Neurol Sci 27:S183-9. 2006
  9. doi request reprint Brain white matter lesions in migraine: what's the meaning?
    Bruno Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Vita Salute University, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 32:S37-40. 2011
  10. ncbi request reprint MRI and motor evoked potential findings in nondisabled multiple sclerosis patients with and without symptoms of fatigue
    B Colombo
    University Department of Neurology, Scientific Institute Ospedale S Raffaele, University of Milan, Italy
    J Neurol 247:506-9. 2000

Collaborators

Detail Information

Publications46

  1. ncbi request reprint fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 28:373-82. 2007
    ..An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients...
  2. doi request reprint Headache therapy with neuronal stabilising drugs
    Bruno Colombo
    Department of Neurology Headache Research Unit, IRCCS San Raffaele University Vita Salute, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 29:S131-6. 2008
    ..Due to these positive results, neuronal stabilisation may be considered as a pivotal approach for headache therapy...
  3. ncbi request reprint Therapy of primary headaches: the role of antidepressants
    B Colombo
    Department of Neurology, Scientific Institute, Ospedale San Raffaele Headache Research Unit, Via Olgettina 48, Milan, Italy
    Neurol Sci 25:S171-5. 2004
    ..Amitriptyline has demonstrated a consistent efficacy in Chronic Tension Type Headache, and Mirtazapine has a promising profile for the treatment of the same disease...
  4. ncbi request reprint Riboflavin and migraine: the bridge over troubled mitochondria
    Bruno Colombo
    Headache Unit, Department of Neurology, San Raffaele Hospital, University Vita Salute, Via Olgettina 48, 20132, Milan, Italy
    Neurol Sci 35:141-4. 2014
    ..Improving brain energy metabolism may reduce the susceptibility to migraine when brain energy demand increases due to both physiological and biopsychological factors. ..
  5. doi request reprint Refractory migraine: the role of the physician in assessment and treatment of a problematic disease
    Bruno Colombo
    Department of Neurology, Headache Center and Institute of Experimental Neurology, IRCCS San Raffaele Hospital, Vita Salute University, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 34:S109-12. 2013
    ..All comorbid factors should be addressed. More invasive modalities (such as neurostimulation) or promising approaches such as repetitive transcranial magnetic stimulation (rTMS) could be a future major step as third line therapies...
  6. doi request reprint From neuroimaging to clinical setting: what have we learned from migraine pain?
    Bruno Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Vita Salute University, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 33:S95-7. 2012
    ..Nevertheless, functional MRI techniques have a vast potential for exploring the pathophysiology of pain in migraine patients...
  7. doi request reprint Ocular pain: a neurological perspective
    Bruno Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Via Olgettina 48, 20132, Milan, Italy
    Neurol Sci 31:S103-5. 2010
    ..A thorough clinical approach is necessary for an appropriate diagnosis and a correct specific management...
  8. ncbi request reprint Medications for neuropathic pain: current trends
    B Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Via Olgettina 48, I 20132, Milan, Italy
    Neurol Sci 27:S183-9. 2006
    ..Therapy is based on tricyclic antidepressants and antiepileptic drugs, the most frequently studied drug classes. Opioids and analgesics are a second-line choice. Topical medications could be useful in several pain situations...
  9. doi request reprint Brain white matter lesions in migraine: what's the meaning?
    Bruno Colombo
    Department of Neurology, Headache Center, IRCCS San Raffaele Hospital, Vita Salute University, Via Olgettina 48, 20100 Milan, Italy
    Neurol Sci 32:S37-40. 2011
    ..The clinical relevance of this brain damage deserves further investigations even if an association between cognitive impairment and migraine or headache of any type is not confirmed...
  10. ncbi request reprint MRI and motor evoked potential findings in nondisabled multiple sclerosis patients with and without symptoms of fatigue
    B Colombo
    University Department of Neurology, Scientific Institute Ospedale S Raffaele, University of Milan, Italy
    J Neurol 247:506-9. 2000
    ..This symptom might be a consequence either of a functional deafferentation of the cortex due to cortico-subcortical interconnection damage or of a demyelination in critical sites of the CNS, such as the cortico-spinal tract...
  11. ncbi request reprint Pyramidal tract lesions and movement-associated cortical recruitment in patients with MS
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 23:141-7. 2004
    ..This study shows that, in patients with MS, following injury of the motor pathways, there is an increased recruitment of a widespread sensorimotor network, which is likely to contribute to limit the appearance of overt clinical deficits...
  12. ncbi request reprint Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes
    Maria A Rocca
    Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy
    Lancet Neurol 4:618-26. 2005
    ..Movement-associated cortical reorganisation is known to occur in multiple sclerosis (MS). We aimed to define the development of such cortical reorganisation by comparing data from patients with different disease phenotypes...
  13. ncbi request reprint Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Stroke 37:1765-70. 2006
    ..We used a 3-T MRI scanner and voxel-based morphometry (VBM) to assess whether GM density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their extent...
  14. doi request reprint A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes
    Antonia Ceccarelli
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 42:315-22. 2008
    ....
  15. doi request reprint Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 254:541-50. 2010
    ....
  16. doi request reprint Patients with migraine do not have MRI-visible cortical lesions
    Martina Absinta
    Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    J Neurol 259:2695-8. 2012
    ..The application of DIR imaging to assess focal cortical involvement seems to be useful in the diagnostic workup of patients with WMHs of unknown etiology, including those with migraine...
  17. doi request reprint Central nervous system dysregulation extends beyond the pain-matrix network in cluster headache
    Maria A Rocca
    Institute of Experimental Neurology, Department of Neuroradiology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Cephalalgia 30:1383-91. 2010
    ..In this study, we investigated whether abnormalities of the brain resting-state networks (RSNs) occur in patients with episodic cluster headache (CH), outside the attacks of the disease...
  18. ncbi request reprint Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, Milan, Italy
    Neuroimage 19:826-36. 2003
    ....
  19. doi request reprint Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes
    Vittorio Martinelli
    Department of Neurology, San Raffaele Hospital, Milan, Italy
    Mult Scler 20:147-55. 2014
    ..Growing evidence suggests that vitamin D deficiency may be one of the most important environmental factors for the development of multiple sclerosis (MS)...
  20. ncbi request reprint Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement--EEG evidence
    L Leocani
    Department of Neurophysiology, Scientific Institute H. San Raffaele, Milan, Italy
    Neuroimage 13:1186-92. 2001
    ....
  21. doi request reprint Structural brain MRI abnormalities in pediatric patients with migraine
    Maria A Rocca
    Division of Neuroscience, Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol 261:350-7. 2014
    ..The presence of such abnormalities early in the disease course, and the absence of correlation with patient clinical characteristics suggest that they may represent a phenotypic biomarker of this condition. ..
  22. doi request reprint Parry Romberg syndrome associated with chronic facial pain
    Gloria Dalla Costa
    Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 48, 20132 Milan, Italy
    J Clin Neurosci 20:1320-2. 2013
    ..Our findings suggest that in this patient PRS-related persistent pain has peculiar features possibly attributed to the underlying musculoskeletal abnormalities. ..
  23. ncbi request reprint Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis
    Paola Tortorella
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Neurol Sci 244:137-41. 2006
    ..In patients with migraine, functional changes have been described in the red nucleus (RN), substantia nigra (SN) and periaqueductal gray matter (PAG)...
  24. ncbi request reprint A functional MRI study of cortical activations associated with object manipulation in patients with MS
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, 20132 Milan, Italy
    Neuroimage 21:1147-54. 2004
    ....
  25. doi request reprint Dizziness, migrainous vertigo and psychiatric disorders
    R Teggi
    Department of ENT, San Raffaele Hospital, Vita Salute University, Milan, Italy
    J Laryngol Otol 124:285-90. 2010
    ..This study sought to establish the prevalence of vestibular disorders, migraine and definite migrainous vertigo in patients with psychiatric disorders who were referred for treatment of dizziness, without a lifetime history of vertigo...
  26. ncbi request reprint Physiopathology and treatment of fatigue in multiple sclerosis
    G Comi
    University of Milan, Department of Neuroscience, Scientific Institute H San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 248:174-9. 2001
    ..No specific treatments are available. Management strategies include medications, exercise, and behavioural therapy; in most cases a combined approach is appropriate...
  27. ncbi request reprint Movement preparation is affected by tissue damage in multiple sclerosis: evidence from EEG event-related desynchronization
    L Leocani
    Department of Neurology, Clinical Neurophysiology and Neurorehabilitation, Scientific Institute, Hospital San Raffaele, University Vita Salute, Via Olgettina 60, 20132 Milan, Italy
    Clin Neurophysiol 116:1515-9. 2005
    ..To investigate the impact of brain tissue damage in Multiple Sclerosis (MS) on the efficiency of programming of voluntary movement, assessed using event-related desynchronization of the EEG...
  28. doi request reprint Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort
    F Martinelli-Boneschi
    Department of Neurology, Institute of Experimental Neurology INSPE, San Raffaele Scientific Institute, Milan, Italy
    Eur J Neurol 17:740-5. 2010
    ....
  29. ncbi request reprint Neuropathic cranial pain
    B Colombo
    Department of Neurology, IRCCS San Raffaele, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 24:S132-7. 2003
    ..The introduction in the therapeutical armamentarium of antiepileptic drugs and the results derived from clinical studies indicate that some of these compounds show promise in the treatment of neuropathic pain...
  30. ncbi request reprint Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study
    M Codella
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol Sci 194:71-4. 2002
    ..These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS...
  31. ncbi request reprint A conventional and magnetization transfer MRI study of the cervical cord in patients with MS
    M Filippi
    Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy
    Neurology 54:207-13. 2000
    ..To evaluate the contribution made by cervical cord damage, assessed using a fast short-tau inversion recovery (fast-STIR) sequence and magnetization transfer ratio (MTR) histogram analysis to the clinical manifestations of MS...
  32. doi request reprint Delayed diagnosis in pediatric headache: an outpatient Italian survey
    Bruno Colombo
    Department of Neurology, Headache Center, INSPE, San Raffaele Hospital Scientific Institute, Vita Salute University, Milano, Italy
    Headache 51:1267-73. 2011
    ..The aim of this prospective study is to assess the time lapse between the onset of recurring headache and the correct diagnosis in a cohort of pediatric patients attending an Italian children's headache center for the first time...
  33. doi request reprint Physiopathology of fatigue in multiple sclerosis
    Letizia Leocani
    Institute of Experimental Neurology Dept of Neurology, Clinical Neurophysiology, Neurorehabilitation, Univ Vita Salute and Scientific Institute San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    Neurol Sci 29:S241-3. 2008
    ....
  34. ncbi request reprint The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study
    C Solaro
    Department of Neurology, P A Micone Hospital, Genova, Italy
    Neurology 63:919-21. 2004
    ..This study underlines the relevance of pain in the clinical history of MS...
  35. ncbi request reprint Cortical function abnormalities in migraine: neurophysiological and neuropsychological evidence from reaction times and event-related potentials to the Stroop test
    P Annovazzi
    Department of Neurology, I R C C S San Raffaele, Via Olgettina 48, I 20132 Milan, Italy
    Neurol Sci 25:S285-7. 2004
    ..We found a slower RTs in patients if compared to controls, supporting the hypothesis of a mild cortical functions impairment even in interictal periods in this group of patients...
  36. doi request reprint Lifetime and actual prevalence of pain and headache in multiple sclerosis
    F Martinelli Boneschi
    Department of Neuro Rehabilitation, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 14:514-21. 2008
    ..Pain and headache in MS are not negligible symptoms and a neurological examination should not miss the assessment of risk factors for specific types of pain for a more specific and individualized treatment...
  37. ncbi request reprint Correlations between structural CNS damage and functional MRI changes in primary progressive MS
    M Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neuroimage 15:537-46. 2002
    ..It also suggests that cortical reorganization might be able to limit the consequences of MS injury in the brain and cervical cord...
  38. doi request reprint Migrainous vertigo: results of caloric testing and stabilometric findings
    Roberto Teggi
    San Raffaele Hospital ENT, Milan, Italy
    Headache 49:435-44. 2009
    ..A central or peripheral vestibular damage may occur in patients with migrainous vertigo. Despite much evidence, at present the International Headache Society classification does not include a specific category for migrainous vertigo...
  39. ncbi request reprint Headache in a population-based elderly cohort. An ancillary study to the Italian Longitudinal Study of Aging (ILSA)
    M Franceschi
    Neurology Department, Scientific Institute H.S. Raffaele, Milan, Italy
    Headache 37:79-82. 1997
    ....
  40. ncbi request reprint Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis
    Clara Guaschino
    Laboratory of Genetics of Neurological Complex Disorders and Department of Neurology, Division of Neuroscience, Institute of Experimental Neurology INSPE, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Neurol Sci 35:789-91. 2014
    ..Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease...
  41. ncbi request reprint Adaptive functional changes in the cerebral cortex of patients with nondisabling multiple sclerosis correlate with the extent of brain structural damage
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute, University Ospedale, San Raffaele, Milan, Italy
    Ann Neurol 51:330-9. 2002
    ..It also suggests that increased recruitment of this cortical network contributes to the limitation of the functional impact of white matter multiple sclerosis injury...
  42. ncbi request reprint An MR study of tissue damage in the cervical cord of patients with migraine
    M Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy
    J Neurol Sci 183:43-6. 2001
    ..MR scanning of the cervical cord in patients with migraine and hyperintense brain lesions of unknown etiology may be a useful investigation to facilitate the diagnostic workout...
  43. pmc A diffusion tensor magnetic resonance imaging study of brain tissue from patients with migraine
    M A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Via Olgettina 60, 20132 Milan, Italy
    J Neurol Neurosurg Psychiatry 74:501-3. 2003
    ..To measure in vivo, using diffusion tensor magnetic resonance imaging (DT-MRI) the extent of pathological damage of normal appearing brain tissue (NABT) from patients with migraine...
  44. doi request reprint The Multiple Sclerosis Knowledge Questionnaire: a self-administered instrument for recently diagnosed patients
    A Giordano
    Unit of Neuroepidemiology, Foundation IRCCS Neurological Institute C Besta, Milan, Italy
    Mult Scler 16:100-11. 2010
    ..In conclusion, the MSKQ has good clinimetric properties and is sensitive to an educational intervention. We propose the MSKQ as a brief instrument for clinical practice and research...
  45. ncbi request reprint Evidence for cortical functional changes in patients with migraine and white matter abnormalities on conventional and diffusion tensor magnetic resonance imaging
    Maria A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Stroke 34:665-70. 2003
    ..We also investigated whether the extent of brain activations was correlated with WM structural pathology measured using diffusion tensor (DT) MRI...
  46. ncbi request reprint A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    Maria A Rocca
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neuroimage 19:1770-7. 2003
    ..It also suggests that, in these patients, functional abilities are sustained by increased recruitment of highly specialized cortical areas...