Emanuele Bosi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Effects of carbohydrate counting on glucose control and quality of life over 24 weeks in adult patients with type 1 diabetes on continuous subcutaneous insulin infusion: a randomized, prospective clinical trial (GIOCAR)
    Andrea Laurenzi
    an Raffaele Vita Salute University, Milan, Italy
    Diabetes Care 34:823-7. 2011
  2. pmc Intensive structured self-monitoring of blood glucose and glycemic control in noninsulin-treated type 2 diabetes: the PRISMA randomized trial
    Emanuele Bosi
    Corresponding authors Emanuele Bosi
    Diabetes Care 36:2887-94. 2013
  3. pmc Frequency-modulated electromagnetic neural stimulation (FREMS) as a treatment for symptomatic diabetic neuropathy: results from a double-blind, randomised, multicentre, long-term, placebo-controlled clinical trial
    E Bosi
    Diabetes and Endocrinology Unit, Department of Internal Medicine, San Raffaele Hospital and San Raffaele Vita Salute University, Via Olgettina 60, 20132 Milan, Italy
    Diabetologia 56:467-75. 2013
  4. ncbi request reprint Effectiveness of frequency-modulated electromagnetic neural stimulation in the treatment of painful diabetic neuropathy
    E Bosi
    Diabetes and Endocrinology Unit, Department of General Medicine, Vita Salute San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Diabetologia 48:817-23. 2005
  5. ncbi request reprint Incretin-based therapies in type 2 diabetes: a review of clinical results
    Emanuele Bosi
    Department of Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and San Raffaele Vita Salute University, Via Olgettina 60, 20132 Milano, Italy
    Diabetes Res Clin Pract 82:S102-7. 2008
  6. doi request reprint Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?
    E Bosi
    Department of Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy
    Diabetes Obes Metab 11:3-8. 2009
  7. ncbi request reprint Time for testing incretin therapies in early type 1 diabetes?
    Emanuele Bosi
    Department of Internal Medicine, San Raffaele Scientific Institute and Vita Salute San Raffaele University, 20132 Milan, Italy
    J Clin Endocrinol Metab 95:2607-9. 2010
  8. ncbi request reprint [Diabetes mellitus]
    E Bosi
    Universit Vita Salute San Raffaele, Istituto Scientifico Ospedale San Raffaele, Milano, Italy
    G Ital Nefrol 20:S3-6. 2003
  9. doi request reprint Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study
    E Bosi
    Department of Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy
    Diabetes Obes Metab 13:1088-96. 2011
  10. ncbi request reprint Increased intestinal permeability precedes clinical onset of type 1 diabetes
    E Bosi
    General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy
    Diabetologia 49:2824-7. 2006

Detail Information

Publications60

  1. pmc Effects of carbohydrate counting on glucose control and quality of life over 24 weeks in adult patients with type 1 diabetes on continuous subcutaneous insulin infusion: a randomized, prospective clinical trial (GIOCAR)
    Andrea Laurenzi
    an Raffaele Vita Salute University, Milan, Italy
    Diabetes Care 34:823-7. 2011
    ..The aim of our study was to test the effect of carbohydrate counting on glycemic control and quality of life in adult patients with type 1 diabetes who are receiving CSII...
  2. pmc Intensive structured self-monitoring of blood glucose and glycemic control in noninsulin-treated type 2 diabetes: the PRISMA randomized trial
    Emanuele Bosi
    Corresponding authors Emanuele Bosi
    Diabetes Care 36:2887-94. 2013
    ..We aimed to evaluate the added value of intensive self-monitoring of blood glucose (SMBG), structured in timing and frequency, in noninsulin-treated patients with type 2 diabetes...
  3. pmc Frequency-modulated electromagnetic neural stimulation (FREMS) as a treatment for symptomatic diabetic neuropathy: results from a double-blind, randomised, multicentre, long-term, placebo-controlled clinical trial
    E Bosi
    Diabetes and Endocrinology Unit, Department of Internal Medicine, San Raffaele Hospital and San Raffaele Vita Salute University, Via Olgettina 60, 20132 Milan, Italy
    Diabetologia 56:467-75. 2013
    ....
  4. ncbi request reprint Effectiveness of frequency-modulated electromagnetic neural stimulation in the treatment of painful diabetic neuropathy
    E Bosi
    Diabetes and Endocrinology Unit, Department of General Medicine, Vita Salute San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy
    Diabetologia 48:817-23. 2005
    ..The aim of this study was to evaluate the efficacy of frequency-modulated electromagnetic neural stimulation (FREMS) as a novel treatment for painful diabetic neuropathy...
  5. ncbi request reprint Incretin-based therapies in type 2 diabetes: a review of clinical results
    Emanuele Bosi
    Department of Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and San Raffaele Vita Salute University, Via Olgettina 60, 20132 Milano, Italy
    Diabetes Res Clin Pract 82:S102-7. 2008
    ..Moreover, exenatide showed a favourable effect on weight, while DPP-4 inhibitors were neutral with respect to this outcome. The low rate of hypoglycemic events seen in all studies confirms the glucose dependent action of incretins...
  6. doi request reprint Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?
    E Bosi
    Department of Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy
    Diabetes Obes Metab 11:3-8. 2009
    ..g. effects on body weight, lipids or blood pressure). In this regard, incretin-based therapies have characteristics that make them particularly suitable for add-on therapy with metformin...
  7. ncbi request reprint Time for testing incretin therapies in early type 1 diabetes?
    Emanuele Bosi
    Department of Internal Medicine, San Raffaele Scientific Institute and Vita Salute San Raffaele University, 20132 Milan, Italy
    J Clin Endocrinol Metab 95:2607-9. 2010
    ..The ideal candidates for this treatment are patients at the time of clinical onset of type 1 diabetes or individuals with preclinical type 1 diabetes who still have a significant viable beta-cell mass...
  8. ncbi request reprint [Diabetes mellitus]
    E Bosi
    Universit Vita Salute San Raffaele, Istituto Scientifico Ospedale San Raffaele, Milano, Italy
    G Ital Nefrol 20:S3-6. 2003
    ..The principal therapeutic innovation of the past ten years is represented by the tight and flexible control of glucose plasma level obtained by using the insulin analogues produced by recombinant DNA technology...
  9. doi request reprint Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study
    E Bosi
    Department of Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy
    Diabetes Obes Metab 13:1088-96. 2011
    ..To assess the efficacy and safety of adding alogliptin versus uptitrating pioglitazone in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone...
  10. ncbi request reprint Increased intestinal permeability precedes clinical onset of type 1 diabetes
    E Bosi
    General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy
    Diabetologia 49:2824-7. 2006
    ..The aim of this study was to investigate this issue by examining intestinal permeability to sugars in subjects at different stages of type 1 diabetes: preclinical, new-onset and long-term established disease...
  11. ncbi request reprint Autoantibody response to islet transplantation in type 1 diabetes
    E Bosi
    Medicine and Surgery, San Raffaele Hospital Scientific Institute, Milan, Italy
    Diabetes 50:2464-71. 2001
    ..These data are consistent with a reactivation of autoimmunity that may be dependent on immunosuppression therapy and is associated with impaired graft function...
  12. ncbi request reprint Fulminant autoimmune Type 1 diabetes during interferon-alpha therapy: a case of Th1-mediated disease?
    E Bosi
    Department of Medicine, San Raffaele Hospital Scientific Institute, University of Milan, Milan, Italy
    Diabet Med 18:329-32. 2001
    ..A case of autoimmune Type 1 diabetes with some unique characteristics developing in a 29-year-old male during treatment with interferon-alpha (IFN-alpha) for chronic hepatitis C virus (HCV) hepatitis is reported...
  13. doi request reprint Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up
    Gianluca Perseghin
    Division of Metabolic and Cardiovascular Sciences, Istituto Scientifico H San Raffaele, Milan, Italy
    Acta Diabetol 49:421-8. 2012
    ..61 95% CI: 1.73-3.94; P < 0.0001). Age- and sex-adjusted analysis showed that hyperinsulinemia/insulin resistance is associated with cancer mortality independently of diabetes, obesity/visceral obesity and the metabolic syndrome...
  14. doi request reprint Fatty liver index and mortality: the Cremona study in the 15th year of follow-up
    Giliola Calori
    Division of Metabolic and Cardiovascular Sciences, H San Raffaele Scientific Institute, Milan, Italy
    Hepatology 54:145-52. 2011
    ..57, P < 0.0001), and when HOMA-IR was included in the multivariate analyses, FLI retained its association with hepatic-related mortality but not with all-cause, CVD, and cancer-related mortality...
  15. doi request reprint Fasting hyperinsulinemia associates with increased sub-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome
    Emanuela Setola
    Cardio Metabolic and Clinical Trials Unit and Cardiodiabetes and Core Lab, Metabolic and Cardiovascular Science Division and Internal Medicine Department, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Metab Res Rev 25:639-46. 2009
    ..To evaluate the influence of gender on the relationship between inflammation and hyperinsulinemia in first-degree relatives of type 2 diabetic patients independently of metabolic syndrome...
  16. pmc Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes
    Lorenzo Piemonti
    Diabetes Research Institute, San Raffaele Hospital Scientific Institute, Milan, Italy
    Diabetes 62:1656-64. 2013
    ..006) against antibody increases. DSA or autoantibody increases after islet transplantation are important prognostic markers, and their identification could potentially lead to improved islet cell transplant outcomes...
  17. doi request reprint L-arginine enriched biscuits improve endothelial function and glucose metabolism: a pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome
    Lucilla D Monti
    Cardio Diabetes and Core Lab Unit, Metabolic and Cardiovascular Science Division, San Raffaele Scientific Institute, Milan, Italy
    Metabolism 62:255-64. 2013
    ..The aim of this study was to evaluate the effects of a new L-arginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition...
  18. doi request reprint Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency
    Emanuela Setola
    Internal Medicine Department, Cardio Diabetes Trials Unit, Scientific Institute San Raffaele, 20132 Milan, Italy
    Metabolism 57:1685-90. 2008
    ..In conclusion, in GHD patients, GH replacement contributes to decreased, to some extent, cardiovascular risk, reducing ADMA levels and improving Arg/ADMA ratio and endothelial dysfunction...
  19. pmc Prospective, randomized trial on intensive SMBG management added value in non-insulin-treated T2DM patients (PRISMA): a study to determine the effect of a structured SMBG intervention
    Marina Scavini
    Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Acta Diabetol 50:663-72. 2013
    ..Inclusion of multiple dependent variables allows us to assess the broader impact of the intervention, including changes in patient and physician attitudes and behaviors...
  20. doi request reprint Effect of normalization of fasting glucose by intensified insulin therapy and influence of eNOS polymorphisms on the incidence of restenosis after peripheral angioplasty in patients with type 2 diabetes: a randomized, open-label clinical trial
    Pier Marco Piatti
    Cardio Metabolism and Clinical Trials Unit, Department of Internal Medicine and Metabolic and Cardiovascular Science Division, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Acta Diabetol 50:373-82. 2013
    ....
  21. ncbi request reprint Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    Emanuele Bosi
    Diabetes and Endocrinology Unit, Department of General Medicine, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Diabetes Care 30:890-5. 2007
    ..We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes...
  22. ncbi request reprint Gluten-free diet in subjects at risk for type 1 diabetes: a tool for delaying progression to clinical disease?
    Emanuele Bosi
    Vita Salute San Raffaele University Hospital, Milan, Italy
    Adv Exp Med Biol 569:157-8. 2005
  23. ncbi request reprint Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease association
    Sandra Piquer
    Immunology of Diabetes Unit, Istituto Scientifico San Raffaele, Milan, Italy
    Clin Immunol 117:31-5. 2005
    ..Exposure to autoantigen in the disorders is likely to involve similar humoral antigenic determinants, but different B cell regulation...
  24. pmc Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4
    Vito Lampasona
    Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 33:104-8. 2010
    ..The aim of this study was to determine the prevalence and role of antibodies to ZnT8 (ZnT8As) in adult-onset diabetes...
  25. doi request reprint Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass
    Pietro Lucotti
    Internal Medicine Department, Cardio Diabetes Trials Unit, Scientific Institute San Raffaele, 20132 Milan, Italy
    Metabolism 58:1270-6. 2009
    ....
  26. doi request reprint Sex hormone-binding globulin: a novel marker for nodal metastases prediction in prostate cancer patients undergoing extended pelvic lymph node dissection
    Andrea Salonia
    Department of Urology, University Vita Salute San Raffaele, Milan, Italy
    Urology 73:850-5. 2009
    ..To examine the association between sex hormone-binding globulin (SHBG) and lymph node invasion (LNI) in patients treated with radical retropubic prostatectomy and extended pelvic lymph node dissection (ePLND)...
  27. ncbi request reprint A novel truncated form of eNOS associates with altered vascular function
    Elena Galluccio
    Cardio Diabetes and Core Lab, Division of Metabolic and Cardiovascular Science, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    Cardiovasc Res 101:492-502. 2014
    ..In the attempt of conferring functional implication to the rs753482-A>C polymorphism, we investigated its influence on transcript maturation...
  28. doi request reprint Treatment of thyroid-associated orbitopathy with rituximab--a novel therapy for an old disease: case report and literature review
    Sara Madaschi
    Department of Internal Medicine, Endocrinology Unit, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Endocr Pract 16:677-85. 2010
    ..To report the use of rituximab to treat thyroid-associated orbitopathy (TAO) in a patient with a concomitant B-cell organ-specific autoimmune disorder-the stiff person syndrome (SPS)...
  29. doi request reprint Menstrual cycle-related changes in circulating androgens in healthy women with self-reported normal sexual function
    Andrea Salonia
    Università Vita Salute San Raffaele Urology, Milan, Italy
    J Sex Med 5:854-63. 2008
    ....
  30. doi request reprint Frequency-modulated electromagnetic neural stimulation enhances cutaneous microvascular flow in patients with diabetic neuropathy
    Morena Conti
    Department of Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
    J Diabetes Complications 23:46-8. 2009
    ..The aim of this study was to investigate the effects of frequency modulated electromagnetic neural stimulation (FREMS), a recently developed safe and effective treatment of painful diabetic neuropathy, on cutaneous microvascular function...
  31. ncbi request reprint Lactulose and mannitol intestinal permeability detected by capillary electrophoresis
    Rita Paroni
    Department of Medicine, Surgery and Dental Science, University of Milan, H San Paolo, Via di Rudini 8, 20142 Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 834:183-7. 2006
    ..Controls (n = 33) and patients (n = 23) had an excretion ratio lactulose/mannitol 0.025 (0.018-0.051) and 0.067 (0.050-0.127), respectively (p < 0.01, median, interquartile range)...
  32. doi request reprint Gastroenteric neuroendocrine neoplasms classification: comparison of prognostic models
    Anna Dolcetta-Capuzzo
    Department of Endocrinology and Internal Medicine, Endocrine Tumors Unit, San Raffaele Scientific Institute, Milan, Italy
    Cancer 119:36-44. 2013
    ..In the current study, the authors evaluated the prognostic significance of these models and compared their efficacy in describing patients' long-term survival to assess the best prognostic model currently available for clinicians...
  33. pmc Defective differentiation of regulatory FoxP3+ T cells by small-intestinal dendritic cells in patients with type 1 diabetes
    Ester Badami
    Experimental Diabetes Unit, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 60:2120-4. 2011
    ..We tested the hypothesis that the intestinal milieu impinges on human T1D by affecting differentiation of FoxP3(+) Treg cells...
  34. doi request reprint Multiple outcomes associated with the use of metformin and sulphonylureas in type 2 diabetes: a population-based cohort study in Italy
    Giovanni Corrao
    Unit of Biostatistics and Epidemiology, Department of Statistics, University of Milano Bicocca, Via Bicocca degli Arcimboldi, 8, Edificio U7, 20126, Milan, Italy
    Eur J Clin Pharmacol 67:289-99. 2011
    ..To compare the effect of metformin and sulphonylureas on the risks of switching to insulin therapy, hospitalisation for macrovascular disease and all-cause mortality...
  35. ncbi request reprint Metabolic and immunological features of the failing islet-transplanted patient
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 31:436-8. 2008
    ..This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure...
  36. doi request reprint Beneficial role of L-arginine in cardiac matrix remodelling in insulin resistant rats
    L D Monti
    Medicine Division, Diabetology and Endocrinology and Metabolic Disease Unit, Scientific Institute San Raffaele, Milan, Italy
    Eur J Clin Invest 38:849-56. 2008
    ....
  37. ncbi request reprint Insulin aspart improves meal time glycaemic control in patients with Type 2 diabetes: a randomized, stratified, double-blind and cross-over trial
    G Perriello
    Section of Internal Medicine, Endocrinology and Metabolism, Department of Internal Medicine, University of Perugia, Italy
    Diabet Med 22:606-11. 2005
    ....
  38. ncbi request reprint Sera from patients with IDDM and healthy individuals have antibodies to ICA69 on western blots but do not immunoprecipitate liquid phase antigen
    V Lampasona
    Department of Laboratory Medicine, Istituto Scientifico H S Raffaele, Milano, Italy
    J Autoimmun 7:665-74. 1994
    ..These data support neither a role for ICA69 as a relevant autoantigen in IDDM, nor a role for the measurement of antibodies to ICA69 in the prediction of IDDM...
  39. ncbi request reprint Hypokalemic periodic paralysis in a patient with acquired growth hormone deficiency
    R Lanzi
    Endocrinology Unit, Department of Internal Medicine, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    J Endocrinol Invest 30:341-5. 2007
    ....
  40. ncbi request reprint Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphoma
    F Folli
    Department of Medicine I, I R C C S H S Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Ann Hematol 81:597-602. 2002
    ..Autoantibodies directed against this novel membrane autoantigen may be an additional serological marker in some cases of Sjögren's syndrome...
  41. ncbi request reprint Macroamylasemia attributable to gluten-related amylase autoantibodies: a case report
    G Barera
    Department of Pediatrics, Scientific Institute H San Raffaele, University of Milan, Milan, Italy
    Pediatrics 107:E93. 2001
    ..We report a girl with CD, autoimmune thyroiditis, and MA, in whom CD-related antibodies to amylase and to exocrine pancreas tissue resolved with a gluten-free diet...
  42. pmc Reduction of circulating neutrophils precedes and accompanies type 1 diabetes
    Andrea Valle
    San Raffaele Scientific Institute, Diabetes Research Institute, Milan, Italy
    Diabetes 62:2072-7. 2013
    ..Our findings suggest the existence of a hitherto unrecognized clinical phenotype that might reflect unexplored pathogenic pathways underlying T1D...
  43. pmc Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice
    Raffaella Melzi
    San Raffaele Diabetes Research Institute HSR DRI, Division of Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 5:e10357. 2010
    ..The aim of this study was to define whether NPC administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model...
  44. ncbi request reprint Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis
    Elena Galluccio
    Scientific Institute San Raffaele, Milan, Italy
    Am J Physiol Endocrinol Metab 294:E978-86. 2008
    ..Hyperinsulinemia, endothelial dysfunction, and a more atherogenic profile seem to be peculiar features of subjects with asymptomatic CAD and restenosis carrying NOS3 gene variants...
  45. ncbi request reprint Low prevalence of islet autoantibodies in patients with gestational diabetes mellitus
    N Dozio
    Department of Medicine, H San Raffaele Scientific Institute, University of Milano, Italy
    Diabetes Care 20:81-3. 1997
    ..To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM...
  46. doi request reprint Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus
    E Bosi
    Department of Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy
    Diabetes Obes Metab 11:506-15. 2009
    ..To compare the efficacy and safety of vildagliptin and metformin initial combination therapy with individual monotherapies in treatment-naive patients with type 2 diabetes mellitus (T2DM)...
  47. pmc Autoantibodies to harmonin and villin are diagnostic markers in children with IPEX syndrome
    Vito Lampasona
    Center for Translational Genomics and Bioinformatics, San Raffaele Hospital Scientific Institute, Milan, Italy
    PLoS ONE 8:e78664. 2013
    ....
  48. ncbi request reprint Six months of gluten-free diet do not influence autoantibody titers, but improve insulin secretion in subjects at high risk for type 1 diabetes
    Matteo Rocco Pastore
    Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Vita Salute University Hospital and Scientific Institute, 20132 Milan, Italy
    J Clin Endocrinol Metab 88:162-5. 2003
    ..These findings indicate that 6 months of gluten deprivation do not influence humoral autoimmunity, but may have a beneficial effect on preservation of beta-cell function in subjects at risk for type 1 diabetes...
  49. ncbi request reprint Sexual function and endocrine profile in fertile women with type 1 diabetes
    Andrea Salonia
    Department of Urology, University Vita Salute San Raffaele, Milano, Italy
    Diabetes Care 29:312-6. 2006
    ....
  50. ncbi request reprint Clinical phenotype and beta-cell autoimmunity in Italian patients with adult-onset diabetes
    S Genovese
    Endocrinology and Diabetes Unit and Biometrical Unit, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Eur J Endocrinol 154:441-7. 2006
    ....
  51. ncbi request reprint Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading
    Cecilia Piani
    General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Via Olgettina 60, Milano, Italy
    Endocr Relat Cancer 15:175-81. 2008
    ..65, 95% CI: 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples...
  52. pmc Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study
    Giliola Calori
    Division of Metabolic and Cardiovascular Sciences, Istituto Scientifico H San Raffaele, Milan, Italy
    Diabetes Care 34:210-5. 2011
    ..Some obese individuals have normal insulin sensitivity. It is controversial whether this phenotype is associated with increased all-cause mortality risk...
  53. doi request reprint High levels of donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation
    A C Ogliari
    Lab of Experimental Surgery, San Raffaele Scientific Institute, Milan, Italy
    Am J Transplant 8:1303-11. 2008
    ..This suggests that the severity of the inflammatory response induced by brain death influences the posttransplant inflammatory response, independent of subsequent ischemia and reperfusion...
  54. ncbi request reprint Antibodies to recombinant human tissue-transglutaminase in coeliac disease: diagnostic effectiveness and decline pattern after gluten-free diet
    E Bazzigaluppi
    Department of Internal Medicine, Scientific Institute H San Raffaele, Vita Salute University, Milan, Italy
    Dig Liver Dis 38:98-102. 2006
    ..To assess the sensitivity and specificity of IgA and IgG tissue-transglutaminase antibodies assay, the pattern of antibody decline after gluten withdrawal and their modifications with reference to dietary compliance...
  55. ncbi request reprint Cytokine profile and insulin antibody IgG subclasses in patients with recent onset type 1 diabetes treated with oral insulin
    L Monetini
    Department of Endocrinology and Diabetes, University Campus Bio Medico, Rome, Italy
    Diabetologia 47:1795-802. 2004
    ..The aim of this study was to evaluate whether this treatment produces a deviation in the immune response, with polarisation of the cytokine pattern and the induction of a Th2-like antibody response...
  56. ncbi request reprint IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)
    G F Bottazzo
    Scientific Directorate, Bambino Gesù Paediatric Hospital, Scientific Institute, Rome, Italy
    Diabetologia 48:703-8. 2005
    ....
  57. ncbi request reprint Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control (UKPDS 70)
    T M E Davis
    University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, P O Box 480, Fremantle, Western Australia, 6959, Australia
    Diabetologia 48:695-702. 2005
    ..We examined the prevalence of islet autoantibodies and their relationship to glycaemic control over 10 years in patients diagnosed clinically with new-onset type 2 diabetes...
  58. ncbi request reprint The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
    L Nistico
    Istituto Clinica Medica II, University of Rome La Sapienza, Italy
    Hum Mol Genet 5:1075-80. 1996
    ..In addition, we provide supporting evidence that CTLA-4 is associated with susceptibility to Graves' disease, another organ-specific autoimmune disease...
  59. pmc Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
    S Trembleau
    Roche Milano Ricerche, Italy
    J Exp Med 181:817-21. 1995
    ..These results hold implications for the pathogenesis, and possibly for the therapy of IDDM and of other Th1 cell-mediated autoimmune diseases...
  60. ncbi request reprint ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes
    V Lampasona
    Diabetologia 44:267. 2001