Marco E Bianchi

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells
    Ingrid E Dumitriu
    H San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 35:2184-90. 2005
  2. ncbi request reprint Significant (re)location: how to use chromatin and/or abundant proteins as messages of life and death
    Marco E Bianchi
    San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
    Trends Cell Biol 14:287-93. 2004
  3. ncbi request reprint DAMPs, PAMPs and alarmins: all we need to know about danger
    Marco E Bianchi
    San Raffaele University, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milan, Italy
    J Leukoc Biol 81:1-5. 2007
  4. ncbi request reprint HMG proteins: dynamic players in gene regulation and differentiation
    Marco E Bianchi
    Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Curr Opin Genet Dev 15:496-506. 2005
  5. ncbi request reprint High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    Marco E Bianchi
    Faculty of Medicine, San Raffaele University, Milano, Italy
    Immunol Rev 220:35-46. 2007
  6. doi request reprint Ancient news: HMGBs are universal sentinels
    Marco E Bianchi
    Chromatin Dynamics Unit, Division of Genetics and Cell Biology, San Raffaele University and Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy
    J Mol Cell Biol 2:116-7. 2010
  7. doi request reprint HMGB1 loves company
    Marco E Bianchi
    San Raffaele University and San Raffaele Research Institute, Department of Genetics and Cell Biology, 20132 Milano, Italy
    J Leukoc Biol 86:573-6. 2009
  8. ncbi request reprint Chromatin and cell death
    Marco E Bianchi
    San Raffaele Scientific Institute, Via Olgettina 58, 4 Piano A1, Milan I 20132, Italy
    Biochim Biophys Acta 1677:181-6. 2004
  9. pmc Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
    Emilie Venereau
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Exp Med 209:1519-28. 2012
  10. doi request reprint Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Milano, Italy
    Ann N Y Acad Sci 1209:83-90. 2010

Detail Information

Publications57

  1. ncbi request reprint Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells
    Ingrid E Dumitriu
    H San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 35:2184-90. 2005
    ..These results reveal HMGB1 and RAGE as the first known autocrine loop modulating the maturation of PDC, and suggest that antagonists of HMGB1/RAGE might have therapeutic potential for the treatment of systemic human diseases...
  2. ncbi request reprint Significant (re)location: how to use chromatin and/or abundant proteins as messages of life and death
    Marco E Bianchi
    San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
    Trends Cell Biol 14:287-93. 2004
  3. ncbi request reprint DAMPs, PAMPs and alarmins: all we need to know about danger
    Marco E Bianchi
    San Raffaele University, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milan, Italy
    J Leukoc Biol 81:1-5. 2007
    ..Endogenous alarmins and exogenous PAMPs therefore convey a similar message and elicit similar responses; they can be considered subgroups of a larger set, the damage-associated molecular patterns (DAMPs)...
  4. ncbi request reprint HMG proteins: dynamic players in gene regulation and differentiation
    Marco E Bianchi
    Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Curr Opin Genet Dev 15:496-506. 2005
    ..Moreover, they contribute to the fine tuning of transcription in response to rapid environmental changes. They do so by interacting with nucleosomes, transcription factors, nucleosome-remodelling machines, and with histone H1...
  5. ncbi request reprint High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    Marco E Bianchi
    Faculty of Medicine, San Raffaele University, Milano, Italy
    Immunol Rev 220:35-46. 2007
    ..These immune responses will also be directed against self-antigens that DCs process at the time of injury and can lead to autoimmunity...
  6. doi request reprint Ancient news: HMGBs are universal sentinels
    Marco E Bianchi
    Chromatin Dynamics Unit, Division of Genetics and Cell Biology, San Raffaele University and Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy
    J Mol Cell Biol 2:116-7. 2010
    ..This appears to be an evolutionary ancient mechanism of virus detection, and possibly might be a facet of a more general propensity of HMGBs to act as integrators of signals that pertain to peace and stress, life and death...
  7. doi request reprint HMGB1 loves company
    Marco E Bianchi
    San Raffaele University and San Raffaele Research Institute, Department of Genetics and Cell Biology, 20132 Milano, Italy
    J Leukoc Biol 86:573-6. 2009
    ..Thus, HMGB1 has dual activities, solo or in company; I speculate that this may serve our body's necessity to sacrifice or reconstruct tissues as required by the presence or absence of pathogens...
  8. ncbi request reprint Chromatin and cell death
    Marco E Bianchi
    San Raffaele Scientific Institute, Via Olgettina 58, 4 Piano A1, Milan I 20132, Italy
    Biochim Biophys Acta 1677:181-6. 2004
    ..Thus, dying cells use their own chromatin to signal how they have died. We argue that the nuclear events in apoptosis serve to control the molecular signals that dying cells send out...
  9. pmc Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
    Emilie Venereau
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Exp Med 209:1519-28. 2012
    ..Thus, HMGB1 orchestrates both key events in sterile inflammation, leukocyte recruitment and their induction to secrete inflammatory cytokines, by adopting mutually exclusive redox states...
  10. doi request reprint Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Milano, Italy
    Ann N Y Acad Sci 1209:83-90. 2010
    ..Moreover, data suggest a potential role for infiltrating alternatively activated macrophages to influence the outcome of inflammatory responses to sterile skeletal muscle necrosis...
  11. pmc Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
    Marianna Penzo
    Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 184:4497-509. 2010
    ..Thus, proinflammatory HMGB1 chemotactic responses mechanistically require the differential collaboration of both IKK-dependent NF-kappaB signaling pathways...
  12. doi request reprint Src family kinases are necessary for cell migration induced by extracellular HMGB1
    Roberta Palumbo
    San Raffaele Research Institute, 20132 Milano, Italy
    J Leukoc Biol 86:617-23. 2009
    ..The ablation of Src or inhibition with the kinase inhibitor PP2 blocks migration toward HMGB1. Src associates to and mediates the phosphorylation of FAK and the formation of focal adhesions...
  13. ncbi request reprint The secretion of HMGB1 is required for the migration of maturing dendritic cells
    Ingrid E Dumitriu
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 81:84-91. 2007
    ..Our data suggest that the autocrine/paracrine release of HMGB1 and the integrity of the HMGB1/RAGE pathway are required for the migratory function of DC...
  14. ncbi request reprint HMGB1: guiding immunity from within
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    Trends Immunol 26:381-7. 2005
    ..The role of HMGB1 as an endogenous molecule that facilitates immune responses and has an important role in tissue homeostasis and disease will be highlighted here...
  15. doi request reprint Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
    Karine Lolmede
    Clinical Cardiovascular Biology Research Center, H San Raffaele Scientific Institute, Milano, Italy
    J Leukoc Biol 85:779-87. 2009
    ..Moreover, they open the possibility of novel strategies, aimed at interfering selectively with signals that recruit blood-derived stem cells toward pro- or anti-inflammatory macrophages...
  16. pmc Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-kappaB activation
    Roberta Palumbo
    Chromatin Dynamics Unit, Stem Cell Research Institute, Istituto Scientifico San Raffaele, 20132 Milan, Italy
    J Cell Biol 179:33-40. 2007
    ..These findings suggest that NF-kappaB signaling controls tissue regeneration in addition to early events in inflammation...
  17. pmc Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    Tiziana Bonaldi
    DIBIT, San Raffaele Scientific Institute, San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
    EMBO J 22:5551-60. 2003
    ..Cytosolic HMGB1 is then concentrated by default into secretory lysosomes, and secreted when monocytic cells receive an appropriate second signal...
  18. ncbi request reprint High mobility group B2 is secreted by myeloid cells and has mitogenic and chemoattractant activities similar to high mobility group B1
    Tobias Pusterla
    San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Autoimmunity 42:308-10. 2009
    ..Since extracellular HMGB2 has been detected in the blood and other biological fluids, it might be necessary to target HMGB2 at the same time as HMGB1 for therapeutical efficacy...
  19. doi request reprint HMGB1 and leukocyte migration during trauma and sterile inflammation
    Emilie Venereau
    San Raffaele University and Scientific Institute, Milan, Italy
    Mol Immunol 55:76-82. 2013
    ..The HMGB1-CXCL12 heterocomplex constitutes a specific target that may hold promise for the treatment of several pathologies...
  20. pmc Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output
    Barbara Celona
    San Raffaele University, Milan, Italy
    PLoS Biol 9:e1001086. 2011
    ..We suggest that variation in nucleosome number, by affecting nucleosomal occupancy both genomewide and gene-specifically, constitutes a novel layer of epigenetic regulation...
  21. ncbi request reprint GR and HMGB1 interact only within chromatin and influence each other's residence time
    Alessandra Agresti
    San Raffaele Research Institute, Via Olgettina 58, 20132 Milan, Italy
    Mol Cell 18:109-21. 2005
    ..We propose that kinetic cooperativity among transcription factors in chromatin binding may be a common feature in transcription and DNA transactions...
  22. ncbi request reprint Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
    Giovanni Sitia
    San Raffaele Scientific Institute, Chromatin Dynamics Unit, Via Olgettina 58, Milan 20132, Italy
    J Leukoc Biol 81:100-7. 2007
    ....
  23. ncbi request reprint Regulation of dendritic- and T-cell fate by injury-associated endogenous signals
    Angelo A Manfredi
    Vita Salute San Raffaele University and San Raffaele Scientific Institute, 20132 Milano, Italy
    Crit Rev Immunol 29:69-86. 2009
    ....
  24. ncbi request reprint Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities
    Luca Mollica
    Biomolecular NMR Laboratory, Dulbecco Telethon Institute, San Raffaele Scientific Institute, Via Olgettina 58, 20133 Milan, Italy
    Chem Biol 14:431-41. 2007
    ..Our results explain in part the anti-inflammatory properties of glycyrrhizin, and might direct the design of new derivatives with improved HMGB1-binding properties...
  25. ncbi request reprint Smooth muscle cells in human atherosclerotic plaques secrete and proliferate in response to high mobility group box 1 protein
    Annalisa Porto
    San Raffaele Scientific Institute, Milan, Italy
    FASEB J 20:2565-6. 2006
    ..Thus, SMCs are both a source and a target of HMGB1; blocking HMGB1 secretion by SMCs can be an important strategy for treatment of atherosclerotic disease and in particular restenosis...
  26. pmc Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis
    Giovanni Sitia
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    PLoS Pathog 7:e1002061. 2011
    ..Overall, these results indicate that KCs resolve rather than worsen liver immunopathology...
  27. ncbi request reprint HMGB1: a signal of necrosis
    Angela Raucci
    San Raffaele Scientific Institute, Milan, Italy
    Autoimmunity 40:285-9. 2007
    ..Because of its powerful activities, HMGB1 is involved in several disorders, including autoimmune ones...
  28. pmc HMGB1 is an endogenous immune adjuvant released by necrotic cells
    Patrizia Rovere-Querini
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milano, Italy
    EMBO Rep 5:825-30. 2004
    ..In vivo, HMGB1 enhances the primary antibody responses to soluble antigens and transforms poorly immunogenic apoptotic lymphoma cells into efficient vaccines...
  29. ncbi request reprint HMGB proteins and gene expression
    Alessandra Agresti
    DIBIT, Istituto Scientifico San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Curr Opin Genet Dev 13:170-8. 2003
    ..Similarly, HMGBs interact with nucleosomes and promote their sliding, but remain bound only for fractions of a second. We argue that HMGBs fluidize chromatin - an action that appears opposite to that of histone H1...
  30. ncbi request reprint Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
    ..Thus, cells undergoing apoptosis are programmed to withhold the signal that is broadcast by cells that have been damaged or killed by trauma...
  31. pmc TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
    Deepak Mittal
    Department of Experimental Oncology, European Institute of Oncology, Milano, Italy
    EMBO J 29:2242-52. 2010
    ..Together, our results suggest that the initial release of HMGB1 triggers a TLR4-dependent inflammatory response that leads to tumour development...
  32. ncbi request reprint Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes
    Angelo A Manfredi
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
    J Immunol 180:2270-5. 2008
    ..Thus the HMGB1-RAGE pathway is a checkpoint in DC maturation and function and a candidate for targeted therapies...
  33. doi request reprint A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
    Angela Raucci
    San Raffaele Scientific Institute, Milan, Italy
    FASEB J 22:3716-27. 2008
    ..Our data do not disprove the interpretation that high levels of soluble forms of RAGE protect against chronic inflammation, but rather suggest that they correlate with high levels of ongoing inflammation...
  34. ncbi request reprint The evolution of High Mobility Group Box (HMGB) chromatin proteins in multicellular animals
    Luca Sessa
    Vita Salute San Raffaele University, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milano, Italy
    Gene 387:133-40. 2007
    ..The organization of HMGB genes was very conserved during Metazoan evolution, with the only deviations appearing in Caenorhabditis and Dipteran (Drosophila and Anopheles) species...
  35. ncbi request reprint HMGB1 interacts differentially with members of the Rel family of transcription factors
    Alessandra Agresti
    DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Biochem Biophys Res Commun 302:421-6. 2003
    ..Functionally, HMGB1 is required for the NF-kappaB-dependent expression of the adhesion molecule VCAM-1...
  36. doi request reprint Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010
    ..Thus, HMGB1-TLR4 signaling may contribute to generating and perpetuating seizures in humans and might be targeted to attain anticonvulsant effects in epilepsies that are currently resistant to drugs...
  37. ncbi request reprint HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain
    Stefania Guazzi
    DIBIT, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy
    Gene Expr Patterns 3:29-33. 2003
    ..Finally, HMGB1 subcellular localization changes during retinoic acid induced differentiation of P19 neuroblastoma cells...
  38. ncbi request reprint High mobility group box 1 protein, a cue for stem cell recruitment
    Roberta Palumbo
    Department of Molecular Biology and Functional Genomics, San Raffaele Research Institute, San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
    Biochem Pharmacol 68:1165-70. 2004
    ..The inflammatory and tissue-regenerating roles of HMGB1 may be strictly interconnected, and are discussed here...
  39. doi request reprint High-mobility group box-1 in ischemia-reperfusion injury of the heart
    Martin Andrassy
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Circulation 117:3216-26. 2008
    ..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear...
  40. pmc The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway
    Stefania Gardella
    National Cancer Research Institute, Genoa, Italy
    EMBO Rep 3:995-1001. 2002
    ..Thus, in monocytes, non-classical secretion can occur through vescicle compartments that are at least partially distinct...
  41. pmc Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
    Roberta Palumbo
    Department of Molecular Biology and Functional Genomics, San Raffaele Research Institute, Milan, Italy
    J Cell Biol 164:441-9. 2004
    ..Although the role of endogenous HMGB1 in the reconstruction of dystrophic muscle remains to be clarified, injected HMGB1 may be used to promote tissue regeneration...
  42. pmc The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding
    Tiziana Bonaldi
    Adolf Butenandt Institut, Molekularbiologie, Schillerstrasse 44, D 80336 MUnchen, Germany
    EMBO J 21:6865-73. 2002
    ..By contrast, an HMGB1 mutant with increased binding affinity was inhibitory. These observations are consistent with a role for HMGB1 as a DNA chaperone facilitating the rate-limiting DNA distortion during nucleosome remodelling...
  43. doi request reprint High-mobility group box 1 protein in human and murine skin: involvement in wound healing
    Stefania Straino
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Invest Dermatol 128:1545-53. 2008
    ..In conclusion, lower HMGB1 levels in diabetic skin may play an important role in impaired wound healing and this defect may be overcome by the topical application of HMGB1...
  44. ncbi request reprint Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation
    Federica Limana
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Circ Res 97:e73-83. 2005
    ..Thus, HMGB1 appears to be a potent inducer of myocardial regeneration following myocardial infarction...
  45. ncbi request reprint Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
    ..The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism...
  46. pmc A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    Valeria V Orlova
    Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 26:1129-39. 2007
    ..Together, a novel HMGB1-dependent pathway for inflammatory cell recruitment and activation that requires the functional interplay between Mac-1 and RAGE is described here...
  47. ncbi request reprint Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability
    Sabrina Giavara
    The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Curr Biol 15:68-72. 2005
    ..Taken together, these data indicate that Nhp6A/B and Hmgb1 protect DNA from damaging agents and thus guard against the generation of genomic aberrations...
  48. pmc Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification
    Noboru Taniguchi
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell Biol 27:5650-63. 2007
    ..Collectively, these findings suggest that HMGB1 released from differentiating chondrocytes acts, at least in part, as a regulator of endochondral ossification during osteogenesis...
  49. pmc A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
    Stanimir Ivanov
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Blood 110:1970-81. 2007
    ..However, lack of intracellular TLR9-associated HMGB1 can be compensated by extracellular HMGB1. Thus, the DNA-binding protein HMGB1 shuttles in and out of immune cells and regulates inflammatory responses to CpG-DNA...
  50. pmc A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity
    Daniela Bosisio
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    EMBO J 25:798-810. 2006
    ..We propose a revision of the enhanceosome concept in this dynamic framework...
  51. ncbi request reprint A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside
    Eugene Y Krynetski
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:100-6. 2003
    ....
  52. pmc Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes
    Coralie Pallier
    Unité de virologie, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France
    Mol Biol Cell 14:3414-26. 2003
    ..A comparable behavior was also observed for two proteins of the HMG-nucleosome binding (HMGN) group, namely, HMGN1 and HMGN2...
  53. ncbi request reprint Multiple effects of high mobility group box protein 1 in skeletal muscle regeneration
    Roberta De Mori
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Arterioscler Thromb Vasc Biol 27:2377-83. 2007
    ..High mobility group box 1 protein (HMGB1) is a cytokine released by necrotic and inflammatory cells in response to injury. We examined the role of HMGB1 in skeletal muscle regeneration after hindlimb ischemia...
  54. ncbi request reprint Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals
    Enzo Lalli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite Louis Pasteur, B P 163, 67404 Illkirch, Strasbourg, France
    J Cell Sci 116:441-5. 2003
    ..The recent identification of a role for the key regulatory factors SRY and WT1(+KTS) in pre-mRNA splicing indicates that important steps in the mammalian sex determination process are likely to operate at the post-transcriptional level...
  55. ncbi request reprint High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells
    Emmanouil Chavakis
    Molecular Cardiology, Department of Internal Medicine III, J W Goethe University of Frankfurt, Frankfurt, Germany
    Circ Res 100:204-12. 2007
    ..These results may provide a platform for the development of novel therapeutic approaches to improve EPC homing...
  56. ncbi request reprint Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule
    Dennis J Sawchuk
    Laboratory of Molecular Immunology and Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:29821-31. 2004
    ....
  57. ncbi request reprint The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes
    Stefan Knapp
    Discovery Research Oncology, Department of Chemistry, Pharmacia Corporation, Viale Pasteur 10, 20014 Nerviano, Italy
    Biochemistry 43:11992-7. 2004
    ..The tail interacts with specific residues in the boxes and shields them from other interactions...