F Benedetti

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    J Clin Psychiatry 66:1535-40. 2005
  2. doi Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences
    F Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychol Med 41:509-19. 2011
  3. ncbi Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, University of Milan School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:36-9. 2005
  4. ncbi Depression and neurological disorders
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Curr Opin Psychiatry 19:14-8. 2006
  5. doi Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Dipartimento di Neuroscienze Cliniche, San Raffaele Turro, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychiatry 75:133-40. 2014
  6. doi Widespread changes of white matter microstructure in obsessive-compulsive disorder: effect of drug status
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Eur Neuropsychopharmacol 23:581-93. 2013
  7. pmc Antidepressant chronotherapeutics for bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Dialogues Clin Neurosci 14:401-11. 2012
  8. pmc Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, Scientific Institute and University Vita Salute, San Raffaele Turro, Milan, Italy
    Neuropsychopharmacology 38:313-27. 2013
  9. doi Caudate gray matter volume in obsessive-compulsive disorder is influenced by adverse childhood experiences and ongoing drug treatment
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Clin Psychopharmacol 32:544-7. 2012
  10. doi Gene-gene interaction of glycogen synthase kinase 3-β and serotonin transporter on human antidepressant response to sleep deprivation
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute San Raffaele and University Vita Salute, Milano, Italy
    J Affect Disord 136:514-9. 2012

Detail Information

Publications67

  1. ncbi Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    J Clin Psychiatry 66:1535-40. 2005
    ..A growing number of clinical studies support the usefulness of chronotherapeutic interventions, such as total sleep deprivation (TSD) and light therapy (LT), in the treatment of nonresistant bipolar depression...
  2. doi Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences
    F Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychol Med 41:509-19. 2011
    ..This study evaluated the effect of ACEs and chronic undifferentiated schizophrenia on neural responses to emotional stimuli (negative facial expression)...
  3. ncbi Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, University of Milan School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:36-9. 2005
    ..This, together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders...
  4. ncbi Depression and neurological disorders
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Curr Opin Psychiatry 19:14-8. 2006
    ..Here we review the most recent findings supporting the hypothesis that major depression is a medical illness of the brain which can be elicited by neurological illnesses...
  5. doi Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Dipartimento di Neuroscienze Cliniche, San Raffaele Turro, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychiatry 75:133-40. 2014
    ..The efficacy of antidepressants on suicidality has been questioned. Total sleep deprivation and light therapy prompt a rapid and stable antidepressant response in bipolar disorder...
  6. doi Widespread changes of white matter microstructure in obsessive-compulsive disorder: effect of drug status
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Eur Neuropsychopharmacol 23:581-93. 2013
    ..Changes of DTI measures in drug-treated OCD patients could reflect pathophysiological underpinnings of OCD, or a yet unexplored part of the mechanism of action of drugs...
  7. pmc Antidepressant chronotherapeutics for bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Dialogues Clin Neurosci 14:401-11. 2012
    ....
  8. pmc Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, Scientific Institute and University Vita Salute, San Raffaele Turro, Milan, Italy
    Neuropsychopharmacology 38:313-27. 2013
    ....
  9. doi Caudate gray matter volume in obsessive-compulsive disorder is influenced by adverse childhood experiences and ongoing drug treatment
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Clin Psychopharmacol 32:544-7. 2012
    ..Robust neuroimaging findings associated OCD with corticostriatal dysfunction and with abnormal morphology and metabolism of cortical areas and basal ganglia...
  10. doi Gene-gene interaction of glycogen synthase kinase 3-β and serotonin transporter on human antidepressant response to sleep deprivation
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute San Raffaele and University Vita Salute, Milano, Italy
    J Affect Disord 136:514-9. 2012
    ..In animals the knockout of GSK3-β counteracts the depressive-like behavioral effects of 5-HT inhibition...
  11. doi Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 32:1863-6. 2008
    ..Results confirm the interest for individual gene variants of the serotonin pathway in shaping clinical characteristics of depression and antidepressant response...
  12. doi Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism
    Francesco Benedetti
    Division of Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Affect Disord 121:68-72. 2010
    ..This finding supports the hypothesis of a major role for catecholamines in the mechanism of action of chronotherapeutics, and for rs4680 in modulating this effect...
  13. doi Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity
    F Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Genes Brain Behav 9:365-71. 2010
    ..These results support the interest for GSK3-beta as a factor affecting neuropathology in major behavioural disorders, such as schizophrenia, and thus as a possible target for treatment...
  14. doi A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Neurosci Lett 445:184-7. 2008
    ..Results need to be confirmed in larger samples, but warrant interest for the variants of molecular clock genes as possible endophenotypes of bipolar disorder...
  15. ncbi Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute, University Vita Salute San Raffaele, Milano, Italy
    Chronobiol Int 24:921-37. 2007
    ..Results are consistent with the known effects of sleep-wake manipulations and neurotransmitter function on the suprachiasmatic nucleus...
  16. ncbi Chronotherapeutics in a psychiatric ward
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Sleep Med Rev 11:509-22. 2007
    ..Chronotherapeutics offer a benign alternative to more radical treatments of depression for the treatment of severe depression in psychiatric wards, but with the advantage of rapidity of onset...
  17. ncbi Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients
    F Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Genes Brain Behav 7:20-5. 2008
    ..Our results support the hypothesis that individual clock genotype may influence several variables linked with human behaviors in normal and psychopathological conditions...
  18. ncbi Neural and genetic correlates of antidepressant response to sleep deprivation: a functional magnetic resonance imaging study of moral valence decision in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences and Neuroradiology, San Raffaele Scientific Institute, Department of Neuropsychiatric Sciences, San Raffaele Turro, Via Stamira d Ancona 20, Milano, Italy
    Arch Gen Psychiatry 64:179-87. 2007
    ..A polymorphism in the promoter for the serotonin transporter influences both antidepressant response and the structure and function of specific brain areas...
  19. ncbi Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:631-5. 2007
    ..Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders...
  20. doi Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Schizophr Res 114:154-60. 2009
    ..Brain imaging studies suggested that ToM and Emp depend on the activation of brain networks mainly localized at the superior temporal lobe and temporo-parietal junction...
  21. doi Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: a 3.0 Tesla study of bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 173:238-42. 2009
    ..We observed that the decrease in the Glx/creatine ratio significantly correlated with the improvement of both objective and subjective measures of depression...
  22. ncbi Neuroimaging and genetics of antidepressant response to sleep deprivation: implications for drug development
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Curr Pharm Des 15:2637-49. 2009
    ....
  23. doi Tract-specific white matter structural disruption in patients with bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Bipolar Disord 13:414-24. 2011
    ....
  24. doi Sleep deprivation in mood disorders
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Neuropsychobiology 64:141-51. 2011
    ....
  25. doi Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute San Raffaele and University Vita Salute, Milan, Italy
    J Affect Disord 135:139-47. 2011
    ..We studied the effect of a positive history of attempted suicide and ongoing lithium treatment on regional GM volumes of patients affected by bipolar depression...
  26. doi Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, San Raffaele Scientific Institute and University Vita Salute, Milan, Italy
    J Affect Disord 132:297-300. 2011
    ..In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide...
  27. doi Disruption of white matter integrity in bipolar depression as a possible structural marker of illness
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Biol Psychiatry 69:309-17. 2011
    ..Literature suggests that WM integrity could be altered in bipolar disorder. Heterogeneity of brain imaging methods, the studied samples, and drug treatments make localization, nature, and severity of the WM abnormalities unclear...
  28. doi Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine
    F Benedetti
    Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele, University Vita Salute San Raffaele, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    Eur Psychiatry 25:476-8. 2010
    ..Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine and paroxetine, but several other studies were negative. No study considered drug plasma levels as possible nuisance covariate...
  29. doi Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Affect Disord 125:341-4. 2010
    ..Previous studies in bipolar patients reported non-significant trends in the same direction...
  30. ncbi Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, University of Vita Salute San Raffaele, School of Medicine, Milano, Italy
    Am J Med Genet B Neuropsychiatr Genet 123:23-6. 2003
    ..Given the post-hoc nature of the finding, replication in independent samples is necessary to confirm it...
  31. ncbi A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy
    Neurosci Lett 355:37-40. 2004
    ....
  32. ncbi Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Universita Vita Salute San Raffaele, School of Medicine, Milan, Italy
    Psychiatry Res 118:241-7. 2003
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. The tested gene variants are not a main factor influencing TSD outcome in bipolar disorder...
  33. ncbi Fluvoxamine treatment of major depression associated with multiple sclerosis
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Universita Vita Salute San Raffaele, School of Medicine, Milan, Italy
    J Neuropsychiatry Clin Neurosci 16:364-6. 2004
    ..Despite a 16.3% attrition rate, 79% of patients achieved response. The drug was well tolerated...
  34. ncbi Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial
    Francesco Benedetti
    Universita Vita Salute San Raffaele, School of Medicine, Department of Neuropsychiatric Sciences, Milano, Italy
    J Clin Psychiatry 64:648-53. 2003
    ..The purpose of the present study was to evaluate the effect of morning light therapy or placebo combined with citalopram in the treatment of patients affected by a major depressive episode without psychotic features...
  35. ncbi Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, School of Medicine, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 26:1167-70. 2002
    ..Our preliminary finding confirms the clinical value of IL-6 baseline concentration as a predictor of response to antidepressant treatment...
  36. ncbi Dopaminergic augmentation of sleep deprivation effects in bipolar depression
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Universita Vita Salute San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychiatry Res 104:239-46. 2001
    ..Despite its theoretical importance, the clinical usefulness of combining TSD with a dopaminergic agent must be questioned...
  37. ncbi Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?
    F Benedetti
    Universita Vita Salute San Raffaele, School of Medicine, Department of Neuropsychiatric Sciences, Via Stamira d Ancona 20 20127, Milano, Italy
    J Psychiatr Res 35:323-9. 2001
    ....
  38. ncbi Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, San Raffaele Turro, 20127 Milano, Italy
    Neurosci Lett 376:51-5. 2005
    ....
  39. ncbi Morning sunlight reduces length of hospitalization in bipolar depression
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Via Prinetti 29, 20127 Milan, Italy
    J Affect Disord 62:221-3. 2001
    ..Bright artificial light improves non-seasonal depression. Preliminary observations suggest that sunlight could share this effect...
  40. doi The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychopharmacology (Berl) 203:155-60. 2009
    ..The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidepressant response gave contrasting results...
  41. ncbi Lormetazepam in depressive insomnia: new evidence of phase-response effects of benzodiazepines
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy
    Int Clin Psychopharmacol 19:311-7. 2004
    ....
  42. ncbi Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita Salute San Raffaele, Milano, Italy
    Biol Psychiatry 54:687-92. 2003
    ..The short-term relapse that follows acute response to TSD has been successfully prevented by combining TSD with light therapy. The mechanism of action of this combined treatment is unknown...
  43. ncbi Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Milano, Italy
    Psychiatry Res 89:107-14. 1999
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. DRD4 exon 3 variants are not a main factor influencing TSD outcome in bipolar disorder...
  44. ncbi Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    Am J Psychiatry 156:1450-2. 1999
    ..The authors tested the hypothesis that the allelic variation of the 5-HTT-linked polymorphic region (5-HTTLPR) could influence the response of depressed patients to total sleep deprivation...
  45. ncbi Changes in medial prefrontal cortex neural responses parallel successful antidepressant combination of venlafaxine and light therapy
    F Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Arch Ital Biol 147:83-93. 2009
    ..A significant interaction of treatment and valence of the stimuli was also detected in other areas that have been widely associated with the depressive illness...
  46. ncbi A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milano, Italy
    Neurosci Lett 368:123-6. 2004
    ....
  47. ncbi Perceived mood and skin body temperature rhythm in depression
    B Barbini
    Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    Eur Arch Psychiatry Clin Neurosci 248:157-60. 1998
    ..A chi-square test confirmed a statistical significance of the discordance between the two rhythms. We discuss our findings hypothesizing a different degree of entrainment of the disease process to the main circadian pacemaker...
  48. ncbi Worsening of delusional depression after sleep deprivation: case reports
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    J Psychiatr Res 33:69-72. 1999
    ....
  49. doi Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder
    S Dallaspezia
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Via Stamira d Ancona 20, Milan, Italy
    Eur Psychiatry 26:138-40. 2011
    ..We showed a relationship between Per3 polymorphism and postpartum depressive onset in bipolar disorder...
  50. ncbi Ongoing lithium treatment prevents relapse after total sleep deprivation
    F Benedetti
    Department of Neuropsychiatric Sciences, Instituto Scientifico Ospedale San Raffaele, University of Milan, School of Medicine, Milano, Italy
    J Clin Psychopharmacol 19:240-5. 1999
    ....
  51. ncbi Patterns of mood variation during antidepressant treatment
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    J Affect Disord 49:133-9. 1998
    ..We confirmed the existence and the predictability of cyclical mood patterns in a subgroup of patients. The absence of a linear improvement in perceived mood did not worsen the final response to antidepressant therapy...
  52. ncbi Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 158:132-40. 2008
    ....
  53. ncbi Serotonin transporter promoter genotype and illness recurrence in mood disorders
    Enrico Smeraldi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University Vita Salute, Via Prinetti 29, 20127, Milan, Italy
    Eur Neuropsychopharmacol 12:73-5. 2002
    ..Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness...
  54. ncbi How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes
    Paola Artioli
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital Scientific Institute, Milan, Italy
    Eur Neuropsychopharmacol 17:587-94. 2007
    ..These preliminary results could shed further light on the involvement of circadian genes in various aspects of physiological and psychopathological mechanisms of the brain...
  55. ncbi Sleep deprivation hastens the antidepressant action of fluoxetine
    F Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, School of Medicine, University of Milan, Italy
    Eur Arch Psychiatry Clin Neurosci 247:100-3. 1997
    ..We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication...
  56. doi Allogeneic transplantation following a reduced-intensity conditioning regimen in relapsed/refractory peripheral T-cell lymphomas: long-term remissions and response to donor lymphocyte infusions support the role of a graft-versus-lymphoma effect
    A Dodero
    Division of Hematology and Bone Marrow Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Leukemia 26:520-6. 2012
    ..At multivariable analysis, refractory disease and age over 45 years were independent adverse prognostic factors. RIC allogeneic SCT is an effective salvage treatment with a better outcome for younger patients with chemosensitive disease...
  57. ncbi The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Centro San Raffaele del Monte Tabor Foundation, Via Stamira d Ancona 20, 20127 Milano, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 29:1074-84. 2005
    ..The present paper reviews the pharmacogenetic studies published to date, focusing the attention on the serotonergic pathway...
  58. ncbi Behavioural sensitization to repeated sleep deprivation in a mice model of mania
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Behav Brain Res 187:221-7. 2008
    ....
  59. doi New perspectives on techniques for the clinical psychiatrist: Brain stimulation, chronobiology and psychiatric brain imaging
    Raffaella Zanardi
    San Raffaele Hospital Department of Psychiatry, Vita Salute University, Milan, Italy
    Psychiatry Clin Neurosci 62:627-37. 2008
    ..The aim was to bridge gaps between the research evidence and clinical decisions, and reach an agreement on several key points of chronobiological and brain stimulation techniques, as well as on relevant objectives for future research...
  60. ncbi Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 121:35-8. 2003
    ..Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP...
  61. ncbi Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness
    Enrico Lattuada
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute, Vita Salute University School of Medicine, via Stamira d Ancona n 20, 20127 Milan, Italy
    Neurosci Lett 367:152-5. 2004
    ..0002, respectively). We conclude that an interaction between clozapine and the CLOCK gene polymorphism 3111 T/C substitution could explain persistent daytime sleepiness in a significant proportion of patients treated with clozapine...
  62. ncbi Dark therapy for mania: a pilot study
    Barbara Barbini
    Department of Neuropsychiatric Sciences, Istituto Scientifico Universitario Ospedale San Raffaele, Milano, Italy
    Bipolar Disord 7:98-101. 2005
    ..Recent findings suggest that extended bed rest and darkness could stabilize mood swings in rapid cycling bipolar patients...
  63. doi Psychiatric diseases
    Daniele Radaelli
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute, San Raffaele San Raffaele Turro, Via Stamira d Ancona 20, 20127, Milan, Italy
    Neurol Sci 29:339-41. 2008
    ....
  64. doi Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation
    Roberto Crocchiolo
    Hematology and Bone Marrow Transplantation Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 114:1437-44. 2009
    ..These data call for revisiting current HLA matching strategies for unrelated HSCT, suggesting that searches should be directed up-front toward identification of HLA-DPB1 permissive, 10 of 10 or 9 of 10 matched donors...
  65. ncbi Melatonin, circadian rhythms, and the clock genes in bipolar disorder
    Sara Dallaspezia
    Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, San Raffaele Turro, Milano, Italy
    Curr Psychiatry Rep 11:488-93. 2009
    ....
  66. doi Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation
    Francesco Benedetti
    J Clin Psychopharmacol 28:249-51. 2008
  67. ncbi Chronotherapeutics (light and wake therapy) in affective disorders
    Anna Wirz-Justice
    Psychol Med 35:939-44. 2005
    ..3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority...