Manuela Battaglia

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
    Alessandra Ferraro
    Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 60:2903-13. 2011
  2. pmc Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
    Nicola Gagliani
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 6:e28434. 2011
  3. ncbi request reprint Induction of transplantation tolerance via regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Immunology of Diabetes Unit, Milan, Italy
    Inflamm Allergy Drug Targets 5:157-65. 2006
  4. ncbi request reprint Potential T regulatory cell therapy in transplantation: how far have we come and how far can we go?
    Manuela Battaglia
    San Raffaele Diabetes Research Institute HSR DRI, Milano, Italy
    Transpl Int 23:761-70. 2010
  5. ncbi request reprint Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 177:8338-47. 2006
  6. ncbi request reprint IL-10-producing T regulatory type 1 cells and oral tolerance
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
    Ann N Y Acad Sci 1029:142-53. 2004
  7. doi request reprint Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes
    Manuela Battaglia
    San Raffaele Diabetes Research Institute, Via Olgettina 58, 20132 Milan, Italy
    Semin Immunol 23:182-94. 2011
  8. ncbi request reprint Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
    Manuela Battaglia
    San Raffaele Scientific Institute, Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Diabetes 55:1571-80. 2006
  9. pmc Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant
    Nicola Gagliani
    San Raffaele Diabetes Research Institute HSR DRI, Milan, Italy
    Diabetes 59:433-9. 2010
  10. pmc Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice
    Andrea Valle
    San Raffaele Diabetes Research Institute, Milan, Italy
    Diabetes 58:875-81. 2009

Collaborators

Detail Information

Publications41

  1. pmc Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
    Alessandra Ferraro
    Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 60:2903-13. 2011
    ..Understanding whether this is a hallmark of patients with type 1 diabetes is a crucial question that is still unsolved, largely due to the difficulties of accessing tissues targeted by the disease...
  2. pmc Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
    Nicola Gagliani
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 6:e28434. 2011
    ..We additionally developed and tested a clinically translatable protocol that used no depleting agent...
  3. ncbi request reprint Induction of transplantation tolerance via regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Immunology of Diabetes Unit, Milan, Italy
    Inflamm Allergy Drug Targets 5:157-65. 2006
    ..This review attempts to summarize the most novel and successful strategies to achieve operational tolerance via induction of Tregs...
  4. ncbi request reprint Potential T regulatory cell therapy in transplantation: how far have we come and how far can we go?
    Manuela Battaglia
    San Raffaele Diabetes Research Institute HSR DRI, Milano, Italy
    Transpl Int 23:761-70. 2010
    ..e. how far have we come) and (iv) predict the future of Treg cell-based therapy in humans (i.e. how far can we go)...
  5. ncbi request reprint Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 177:8338-47. 2006
    ....
  6. ncbi request reprint IL-10-producing T regulatory type 1 cells and oral tolerance
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
    Ann N Y Acad Sci 1029:142-53. 2004
    ..Overall, these data demonstrate that IL-10-producing Tr1 cells play a central role in the induction of oral as well as systemic tolerance...
  7. doi request reprint Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes
    Manuela Battaglia
    San Raffaele Diabetes Research Institute, Via Olgettina 58, 20132 Milan, Italy
    Semin Immunol 23:182-94. 2011
    ..In the present review we will attempt to consolidate learning from the past and to describe what we now believe could in the future become a successful Treg-cell based immune intervention in T1D...
  8. ncbi request reprint Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
    Manuela Battaglia
    San Raffaele Scientific Institute, Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Diabetes 55:1571-80. 2006
    ..Rapamycin plus IL-10 treatment, promoting distinct subsets of Tr cells, may constitute a novel and potent tolerance-inducing protocol for immune-mediated diseases...
  9. pmc Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant
    Nicola Gagliani
    San Raffaele Diabetes Research Institute HSR DRI, Milan, Italy
    Diabetes 59:433-9. 2010
    ..This study was designed to define the efficacy of Tr1-cell therapy in preclinical models of islet transplant...
  10. pmc Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice
    Andrea Valle
    San Raffaele Diabetes Research Institute, Milan, Italy
    Diabetes 58:875-81. 2009
    ..We used the NOD mouse model to test whether rapamycin, a compound well-known for its immunomodulatory activity in mice and humans, could increase the therapeutic effectiveness of anti-CD3 treatment in type 1 diabetes...
  11. pmc Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 57:2341-7. 2008
    ..Preclinical murine models have shown that rapamycin enhances nTreg proliferation and regulatory function also in vivo. Objective of this study was to assess whether rapamycin has in vivo effects on human nTregs...
  12. ncbi request reprint Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Diabetes 55:40-9. 2006
    ..Thus rapamycin plus IL-10 not only prevented allograft rejection but also induced Tr1 cells that mediated stable antigen-specific, long-term tolerance in vivo...
  13. ncbi request reprint Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  14. doi request reprint Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
    ..Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells...
  15. doi request reprint Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?
    Nicola Gagliani
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, 20132 Milano, Italy
    Immunol Lett 127:1-7. 2009
    ..We also provide our view on how Treg therapy can achieve the final goal of immunological tolerance in the extremely challenging clinical setting of type 1 diabetic subjects transplanted with allogeneic islets...
  16. pmc Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells
    Eleonora Tresoldi
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Haematologica 96:1357-65. 2011
    ..Here we investigated the Th17-cell content and the in vivo stability of rapamycin-expanded T-regulatory cells as pertinent aspects of cell-based therapy...
  17. doi request reprint Expanding human T regulatory cells with the mTOR-inhibitor rapamycin
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Methods Mol Biol 821:279-93. 2012
    ..Here, we describe in detail the powerful methods for enriching human FOXP3(+) Treg cells starting from unfractionated CD4(+) T cells or for expanding CD25(+)-enriched Treg cells in the presence of rapamycin...
  18. ncbi request reprint The role of interleukin 10 in the control of autoimmunity
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Autoimmun 20:269-72. 2003
  19. doi request reprint Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes
    Lorenzo Piemonti
    San Raffaele Diabetes Research Institute HSR DRI, 20132, Milano, Italy
    Adv Exp Med Biol 654:725-47. 2010
    ....
  20. pmc Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice
    Raffaella Melzi
    San Raffaele Diabetes Research Institute HSR DRI, Division of Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 5:e10357. 2010
    ..The aim of this study was to define whether NPC administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model...
  21. ncbi request reprint Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 212:28-50. 2006
    ....
  22. doi request reprint STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
    Laura Passerini
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Int Immunol 20:421-31. 2008
    ..These data indicate that activation of STAT5 sustains FOXP3 expression in both Treg and Teff cells and contribute to our understanding of how cytokines affect the expression of FOXP3...
  23. ncbi request reprint Relevance of hyperglycemia on the timing of functional loss of allogeneic islet transplants: implication for mouse model
    Raffaella Melzi
    Immunology of Diabetes Unit, San Raffaele Scientific Institute, Milan, Italy
    Transplantation 83:167-73. 2007
    ..In this study, we investigated if and how variation in recipient glycemia affects the ability to achieve and maintain normoglycemia after transplant of C57BL/6 islets into diabetic BALB/c mice...
  24. ncbi request reprint The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells
    Andrea Annoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 110:1788-96. 2007
    ..These data indicate that antitransgene immune response can be modulated by transgene-expressing APCs possibly through deletion of effector T cells...
  25. ncbi request reprint Re-establishing immune tolerance in type 1 diabetes via regulatory T cells
    Silvia Gregori
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Novartis Found Symp 292:174-83; discussion 183-6, 202-3. 2008
    ..In vitro expansion/induction of Tregs can be therefore envisaged as a therapeutic tool for re-establishing self-tolerance in T1D subjects...
  26. ncbi request reprint The role of cytokines (and not only) in inducing and expanding T regulatory type 1 cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Transplantation 77:S16-8. 2004
    ..Whether this combined treatment can also be used in humans is still an open question...
  27. doi request reprint Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
    Marianna Esposito
    Clinical Neuroimmunology Unit, Department of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute DIBIT, Milan, Italy
    J Neuroimmunol 220:52-63. 2010
    ..Our data show that rapamycin inhibits RR-EAE, provide evidence for the immunological mechanisms, and indicate this compound as a potential candidate for the treatment of multiple sclerosis...
  28. pmc WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells
    Francesco Marangoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, 20132 Milan, Italy
    J Exp Med 204:369-80. 2007
    ..Thus, WASP appears to play an important role in the activation and suppressor function of nTreg cells, and a dysfunction or incorrect localization of nTreg cells may contribute to the development of autoimmunity in WAS patients...
  29. pmc Reduction of circulating neutrophils precedes and accompanies type 1 diabetes
    Andrea Valle
    San Raffaele Scientific Institute, Diabetes Research Institute, Milan, Italy
    Diabetes 62:2072-7. 2013
    ..Our findings suggest the existence of a hitherto unrecognized clinical phenotype that might reflect unexplored pathogenic pathways underlying T1D...
  30. ncbi request reprint Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation
    Silvia Gregori
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Curr Opin Hematol 12:451-6. 2005
    ....
  31. doi request reprint The Tregs' world according to GARP
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
    Eur J Immunol 39:3296-300. 2009
    ..In addition, GARP binds directly to LAP; yet, GARP over-expression is insufficient to induce modification of latent TGF-beta into active TGF-beta further clarifying its role in nTreg-mediated suppression...
  32. ncbi request reprint Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Curr Top Microbiol Immunol 380:39-68. 2014
    ..Finally, we highlight the pathological settings in which Tr1 cells can be beneficial to prevent or to cure the disease. ..
  33. doi request reprint Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity
    Georgia Fousteri
    San Raffaele Scientific Institute, Diabetes Research Institute, Via Olgettina 58, Milan, Italy Electronic address
    Clin Immunol 149:556-65. 2013
    ..We focus particularly on the complexity that underlies the function of PTPN22 in the biological processes of the immune system; such complexity has led various research groups to produce rather conflicting data. ..
  34. pmc Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells
    Megan K Levings
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Exp Med 196:1335-46. 2002
    ..Together these data indicate that naturally occurring human CD25(+)CD4(+) T cells are distinct from IL-10-producing Tr1 cells...
  35. ncbi request reprint Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Nat Rev Immunol 7:585-98. 2007
    ....
  36. ncbi request reprint The puzzling world of murine T regulatory cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    Microbes Infect 4:559-66. 2002
    ..This review describes the considerable progress made in the recent years in the characterization of the many subsets that constitute the puzzled world of murine T regulatory cells...
  37. ncbi request reprint Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25- (nonregulatory) T cells
    Chao Yan Liu
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 174:2680-6. 2005
    ....
  38. ncbi request reprint Allogeneic mesoangioblasts give rise to alpha-sarcoglycan expressing fibers when transplanted into dystrophic mice
    Maria Guttinger
    Institute for Cell Biology and Tissue Engineering, Fondazione Parco Biomedico San Raffaele, Via Castel Romano 100, 10028 Rome, Italy
    Exp Cell Res 312:3872-9. 2006
    ....
  39. ncbi request reprint Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove
    Manuela Battaglia
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201 2178, USA
    Hum Immunol 63:91-100. 2002
    ..These results raise the prospect that immune suppression of selected T cells during allo-transplantation can simultaneously modulate direct and indirect alloreactivities...
  40. ncbi request reprint Evidence for preferred MHC class II-TCR recognition independent of the source of bound peptide
    Manuela Battaglia
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201 2178 USA
    Eur J Immunol 32:2179-87. 2002
    ..Our results support the hypothesis that certain V gene products may have a preference for interacting with a particular MHC molecule, and this could have an impact in selectively controlling immune responses...
  41. pmc A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome
    Veronica Marrella
    Human Genome Department, Istituto di Tecnologie Biomediche, CNR, Via Fratelli Cervi 93, Segrate, Milan 20090, Italy
    J Clin Invest 117:1260-9. 2007
    ..In conclusion, Rag2(R229Q/R229Q) mice mimicked most symptoms of human OS; our findings support the notion that impaired immune tolerance and defective immune regulation are involved in the pathophysiology of OS...