Andrea Bacigalupo

Summary

Affiliation: San Martino University Hospital
Country: Italy

Publications

  1. ncbi request reprint Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation
    Andrea Bacigalupo
    Divisione di Ematologia, Ospedale San Martino, Genova
    Biol Blood Marrow Transplant 12:560-5. 2006
  2. doi request reprint Diagnosis and treatment of acquired aplastic anemia
    Andrea Bacigalupo
    Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino Largo, Rosanna Benzi 10, Genova 16132, Italy
    Hematol Oncol Clin North Am 23:159-70. 2009
  3. doi request reprint Acute bronchodilator responsiveness in bronchiolitis obliterans syndrome following hematopoietic stem cell transplantation
    Giovanni Barisione
    Unità Operativa Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria San Martino, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    Chest 139:633-9. 2011
  4. doi request reprint Matched and mismatched unrelated donor transplantation: is the outcome the same as for matched sibling donor transplantation?
    Andrea Bacigalupo
    1Istituto di Ricovero e Cura a Carattere Scientifico San Martino, Genova, Italy
    Hematology Am Soc Hematol Educ Program 2012:223-9. 2012
  5. doi request reprint Foscarnet in the management of cytomegalovirus infections in hematopoietic stem cell transplant patients
    Andrea Bacigalupo
    Department of Hematology, Ospedale San Martino, Genova, Italy
    Expert Rev Anti Infect Ther 10:1249-64. 2012
  6. pmc Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto, IRCCS San Martino IST, Genova, Italy
    Haematologica 97:1142-8. 2012
  7. doi request reprint Late pulmonary complications after allogeneic hematopoietic stem cell transplantation: diagnosis, monitoring, prevention, and treatment
    Andrea Bacigalupo
    Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Semin Hematol 49:15-24. 2012
  8. ncbi request reprint Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation
    Andrea Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genoa, Italy
    Haematologica 89:1238-47. 2004
  9. pmc Defining the intensity of conditioning regimens: working definitions
    Andrea Bacigalupo
    San Martino Hospital, Genoa, Italy
    Biol Blood Marrow Transplant 15:1628-33. 2009
  10. doi request reprint Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type
    A Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:458-63. 2010

Detail Information

Publications91

  1. ncbi request reprint Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation
    Andrea Bacigalupo
    Divisione di Ematologia, Ospedale San Martino, Genova
    Biol Blood Marrow Transplant 12:560-5. 2006
    ....
  2. doi request reprint Diagnosis and treatment of acquired aplastic anemia
    Andrea Bacigalupo
    Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino Largo, Rosanna Benzi 10, Genova 16132, Italy
    Hematol Oncol Clin North Am 23:159-70. 2009
    ..This article reviews the key diagnostic and prognostic factors that influence the choice of therapy in patients with acquired aplastic anemia...
  3. doi request reprint Acute bronchodilator responsiveness in bronchiolitis obliterans syndrome following hematopoietic stem cell transplantation
    Giovanni Barisione
    Unità Operativa Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria San Martino, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    Chest 139:633-9. 2011
    ..We studied whether nonconventional assessment of bronchodilation may help to detect physiologically meaningful airway responses missed by traditional criteria...
  4. doi request reprint Matched and mismatched unrelated donor transplantation: is the outcome the same as for matched sibling donor transplantation?
    Andrea Bacigalupo
    1Istituto di Ricovero e Cura a Carattere Scientifico San Martino, Genova, Italy
    Hematology Am Soc Hematol Educ Program 2012:223-9. 2012
    ....
  5. doi request reprint Foscarnet in the management of cytomegalovirus infections in hematopoietic stem cell transplant patients
    Andrea Bacigalupo
    Department of Hematology, Ospedale San Martino, Genova, Italy
    Expert Rev Anti Infect Ther 10:1249-64. 2012
    ..In patients receiving hematopoietic stem cell transplantation, it has proven efficacy when used pre-emptively to treat CMV reactivation, as an alternative to and also in combination with ganciclovir...
  6. pmc Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto, IRCCS San Martino IST, Genova, Italy
    Haematologica 97:1142-8. 2012
    ..The aim of this study was to test whether this currently also holds true for older patients with acquired aplastic anemia...
  7. doi request reprint Late pulmonary complications after allogeneic hematopoietic stem cell transplantation: diagnosis, monitoring, prevention, and treatment
    Andrea Bacigalupo
    Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Semin Hematol 49:15-24. 2012
    ..It would be also important to improve understanding of the biological heterogeneity of this devastating complication after allo-HSCT...
  8. ncbi request reprint Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation
    Andrea Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genoa, Italy
    Haematologica 89:1238-47. 2004
    ..The aims of this study were to determine whether these relationships still hold and whether the outcome of transplants is continuing to improve...
  9. pmc Defining the intensity of conditioning regimens: working definitions
    Andrea Bacigalupo
    San Martino Hospital, Genoa, Italy
    Biol Blood Marrow Transplant 15:1628-33. 2009
    ..Standardized classification of conditioning regimen intensities will allow comparison across studies and interpretation of study results...
  10. doi request reprint Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type
    A Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:458-63. 2010
    ..In conclusion, PMF patients undergoing an allogeneic HSCT may be scored according to the spleen size, transfusion history and donor type; this scoring system may be useful to discuss transplant strategies...
  11. ncbi request reprint Management of acute graft-versus-host disease
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto di Midollo, Ospedale San Martino, Genova, Italy
    Br J Haematol 137:87-98. 2007
    ..Acute GvHD is complicated by severe immunodeficiency causing life-threatening infections. To date, GvHD has not been differentiated from the graft-versus-leukaemia effect. The present review will discuss some of these aspects...
  12. ncbi request reprint Allogeneic hemopoietic stem cell transplants for patients with relapsed acute leukemia: long-term outcome
    A Bacigalupo
    Divisione di Ematologia 2, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 39:341-6. 2007
    ....
  13. doi request reprint Pre-emptive treatment of acute GVHD: a randomized multicenter trial of rabbit anti-thymocyte globulin, given on day+7 after alternative donor transplants
    A Bacigalupo
    Divisione Ematologia, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:385-91. 2010
    ..These results may represent a platform for risk-adapted post transplant immune modulation...
  14. ncbi request reprint Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: a report from the EBMT-SAA Working Party
    A Bacigalupo
    Department of Hematology 2, Azienda Ospedaliera Universitaria San Martino, Largo Benzi, Genova, Italy
    Bone Marrow Transplant 36:947-50. 2005
    ..The significant risk of graft failure in patients 15 years or older may require modification of the conditioning regimen in adults...
  15. doi request reprint Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning
    Anna Maria Raiola
    Divisione Ematologia e Trapianto di Midollo, IRCCS San Martino, Genova, Italy
    Biol Blood Marrow Transplant 19:117-22. 2013
    ..In conclusion, an MA conditioning regimen followed by haploidentical BMT with PT-CY results in a low risk of aGVHD and cGVHD and encouraging rates of TRM and DFS...
  16. doi request reprint The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hematopoietic diseases
    Francesco Frassoni
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, Genova, Italy
    Best Pract Res Clin Haematol 23:237-44. 2010
    ..A suitable CBU was found for nearly every patient searching for a CBU. Therefore, IB CBT extends the possibility to transplant any patient for whom this approach represents the sole possibility of long-term survival...
  17. ncbi request reprint Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors
    Marina Podesta
    Department of Hematology, 2nd Division, Pad 5, S Martino Hospital, Largo R Benzi 10, 16132 Genova, Italy
    J Biol Chem 280:5343-9. 2005
    ..These results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis...
  18. doi request reprint CMV infection after transplant from cord blood compared to other alternative donors: the importance of donor-negative CMV serostatus
    Małgorzata Mikulska
    Division of Infectious Diseases, San Martino University Hospital, Genoa, Italy
    Biol Blood Marrow Transplant 18:92-9. 2012
    ..The duration and incidence of late CMV infection were similar when D-/R+ CBT were compared with D-/R+ alternative donor transplants...
  19. doi request reprint Leukaemia relapse after allogeneic transplants for acute myeloid leukaemia: predictive role of WT1 expression
    Sarah Pozzi
    Divisione Ematologia e Trapianto di Midollo, IRCCS San Martino IST, Genova, Italy
    Br J Haematol 160:503-9. 2013
    ..In conclusion, WT1 expression post-HSCT is a strong predictor of leukaemia relapse and survival in AML; WT1 may be used as a marker for early interventional therapy...
  20. ncbi request reprint Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation
    Alida Dominietto
    Dipartimento di Ematologia Ospedale San Martino, Genova, Italy
    Blood 100:3930-4. 2002
    ..02), and recipient age (P =.02). In conclusion, transplantation of high marrow cell dose is associated with reduced transplant mortality and improved survival and results in improved graft function both short and long term...
  21. ncbi request reprint Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation
    Alessandra Larocca
    Divisione Ematologia, Ospedale San Gerardo, Monza, Milano, Italy
    Haematologica 91:935-40. 2006
    ..It is uncertain whether a boost of donor marrow or blood cells is beneficial in terms of trilineage recovery and non-relapse-related mortality (NRM)...
  22. doi request reprint CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence
    Patrizia Piccioli
    Medical Oncology C, National Cancer Research Institute, Genoa, Italy
    Ann Hematol 89:613-8. 2010
    ..However, only recipient +49A>G polymorphism was retained as independent prognostic factor in a multivariate analysis, suggesting that the expression of CTLA-4 on the cells of recipient may be relevant for the clinical outcome of HSCT...
  23. doi request reprint Rituximab treatment for Epstein-Barr virus DNAemia after alternative-donor hematopoietic stem cell transplantation
    Stefania Coppoletta
    Division of Hematology and Bone Marrow Transplant, Ospedale San Martino, Genova, Italy
    Biol Blood Marrow Transplant 17:901-7. 2011
    ..Patients with increasing EBV copies despite rituximab therapy are at high risk for EBV PTLD and may be considered for alternative therapies...
  24. pmc Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: a retrospective study from the EBMT-SAA Working Party
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Haematologica 95:976-82. 2010
    ..We analyzed the outcome of 100 patients with acquired severe aplastic anemia undergoing an alternative donor transplant, after immune suppressive therapy had failed...
  25. doi request reprint Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study
    Francesco Frassoni
    Stem Cells and Cell Therapy Centre, San Martino Hospital, Genoa, Italy
    Lancet Oncol 9:831-9. 2008
    ..The aim of this phase I/II study was to establish the safety and efficacy of a new administration route (intrabone) for cord-blood cells, measured by the donor-derived neutrophil and platelet engraftment...
  26. ncbi request reprint Treatment of acute graft versus host disease with low dose-alternate day anti-thymocyte globulin
    Francesco Graziani
    Dipartimento di Ematologia, Ospedale San Martino, Genoa, Italy
    Haematologica 87:973-8. 2002
    ..In the present study we report on the use of low dose ATG (thymoglobuline, Sangstat) and steroids in 28 patients with moderate to severe acute GvHD...
  27. pmc Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia
    Carlo Dufour
    Haematology Unit, G Gaslini Children s Hospital, Genoa, Italy
    Haematologica 94:1743-7. 2009
    ....
  28. doi request reprint Imatinib for refractory chronic graft-versus-host disease with fibrotic features
    Attilio Olivieri
    Department of Hematology, San Carlo Hospital, via Potito Petrone 1, Potenza, Italy
    Blood 114:709-18. 2009
    ..The 18-month probability of overall survival is 84%. This study suggests that imatinib is a promising treatment for patients with refractory fibrotic cGVHD...
  29. ncbi request reprint Female genital tract graft-versus-host disease following allogeneic bone marrow transplantation
    Simonetta Spinelli
    Dipartimento di Ematologia S Martino, Genova, Italy
    Haematologica 88:1163-8. 2003
    ..We tried to evaluate the incidence of genital tract involvement and whether there are specific risk factors...
  30. doi request reprint Prophylaxis and treatment of invasive fungal diseases in allogeneic stem cell transplantation: results of a consensus process by Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
    Corrado Girmenia
    Department of Hematology, Policlinico Umberto I, University of Sapienza, Rome, Italy
    Clin Infect Dis 49:1226-36. 2009
    ....
  31. ncbi request reprint Adding low-dose gemtuzumab ozogamicin to fludarabine, Ara-C and idarubicin (MY-FLAI) may improve disease-free and overall survival in elderly patients with non-M3 acute myeloid leukaemia: results of a prospective, pilot, multi-centre trial and comparison
    Marino Clavio
    Department of Haematology and Oncology, University of Genova and S Martino Hospital, Genova, Italy
    Br J Haematol 138:186-95. 2007
    ..This GO-based induction chemotherapy has a good toxicity profile. In keeping with a recent prospective randomised trial, the addition of GO seems to prolong disease-free survival...
  32. ncbi request reprint Laparoscopic lymph node biopsy in intra-abdominal lymphoma: high diagnostic accuracy achieved with a minimally invasive procedure
    Marco Casaccia
    Departments of General and Transplant Surgery, University of Genoa, San Martino Hospital, Genoa, Italy
    Surg Laparosc Endosc Percutan Tech 17:175-8. 2007
    ..LLB can be proposed as the procedure of choice to sample deep lymphatic tissues in patients with intra-abdominal lymphadenopathy at a very low morbidity rate and as an outpatient procedure in selected cases...
  33. doi request reprint Endothelial colony-forming cells from patients with chronic myeloproliferative disorders lack the disease-specific molecular clonality marker
    Giovanna Piaggio
    Divisione Ematologia, Ospedale San Martino, Genova
    Blood 114:3127-30. 2009
    ....
  34. doi request reprint Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index: a prospective, multicenter GITMO study
    Roberto Raimondi
    Department of Hematology, S Bortolo Hospital, Vicenza, Italy
    Blood 120:1327-33. 2012
    ..66, 064, and 0.59, respectively). We confirm the clinical utility of the HCT-CI score that could also identify patients at low NRM risk possibly benefiting from an HSCT-based treatment strategy...
  35. ncbi request reprint False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam
    Claudio Viscoli
    Infectious Disease Unit, National Institute for Cancer Research and University of Genoa, Genoa, Italy
    Clin Infect Dis 38:913-6. 2004
    ..Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results...
  36. doi request reprint Helical tomotherapy targeting total bone marrow after total body irradiation for patients with relapsed acute leukemia undergoing an allogeneic stem cell transplant
    Renzo Corvò
    Department of Radiation Oncology, University of Genoa and National Cancer Research Institute, Largo R Benzi 10, Genoa, Italy
    Radiother Oncol 98:382-6. 2011
    ..To report our clinical experience in planning and delivering total marrow irradiation (TMI) after total body irradiation (TBI) in patients with relapsed acute leukemia undergoing an allogeneic stem-cell transplant (SCT)...
  37. ncbi request reprint Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti-thymocyte globulin
    Maria Teresa Van Lint
    Divisione Ematologia 2, Ospedale San Martino, 16132 Genoa, Italy
    Blood 107:4177-81. 2006
    ....
  38. doi request reprint Airway distensibility with lung inflation after allogeneic haematopoietic stem-cell transplantation
    Giovanni Barisione
    Fisiopatologia Respiratoria, IRCCS Azienda Ospedaliera Universitaria San Martino IST, Genoa, Italy
    Respir Physiol Neurobiol 184:80-5. 2012
    ..This effect seems to be related to an increase in lung stiffness and must be taken into account when interpreting lung function changes after HSCT...
  39. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology, IRCCS Policlinico S Matteo, Pavia and Second Division of Hematology, Ospedale San Martino, Viale Golgi 19, 27100 Genoa, Italy
    Curr Opin Hematol 13:74-8. 2006
    ....
  40. ncbi request reprint Bone marrow or peripheral blood as a source of stem cells for allogeneic transplantation
    Andrea Bacigalupo
    Divisione Ematologia 2 PAD 5 II, Ospedale San Martino, 16132 Genoa, Italy
    Haematologica 87:4-8. 2002
    ..The aim of this report is to review available data on PB vs BM hematopoietic stem cell transplantation (HSCT). The discussion is restricted to unmanipulated HLA identical sibling transplants...
  41. ncbi request reprint Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation
    Francesco Frassoni
    Centro Cellule Staminali e Terapia Cellulare, Dipartimento Emato Oncologia, Ospedale San Martino, 16132 Genova, Italy
    Blood 102:1138-41. 2003
    ....
  42. ncbi request reprint Clinical scale ex vivo expansion of cord blood-derived outgrowth endothelial progenitor cells is associated with high incidence of karyotype aberrations
    Mirko Corselli
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, Genova, Italy
    Exp Hematol 36:340-9. 2008
    ..In this study, we evaluated the expansion potential of CB EPCs together with their phenotypic, functional, and chromosomal stability over time...
  43. ncbi request reprint Management of acute graft versus host disease (GvHD)
    Andrea Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genova, Italy
    Hematol J 5:189-96. 2004
    ..We have considerably reduced the risk of acute GvHD over the past three decades: we need to further improve these results, with the final goal of dissecting, if possible, the graft versus host from the graft versus tumor effect...
  44. ncbi request reprint Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients
    Carlo Dufour
    Hematology Unit, Department of Pediatric Hemato Oncology, Giannina Gaslini Children s Hospital, Genoa, Italy
    Haematologica 90:1027-31. 2005
    ..We assessed whether, in a Caucasian population, low or null activity polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 were associated with the risk of developing aplastic anemia and with the response to immunosuppressive therapy...
  45. ncbi request reprint Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice
    Marina Podesta
    Department of Hematology, 2nd Division, S Martino Hospital, Genoa, Italy
    FASEB J 17:310-2. 2003
    ....
  46. ncbi request reprint Antithymocyte globulin for prevention of graft-versus-host disease
    Andrea Bacigalupo
    Divisione Ematologia II, Ospedale San Martino, 16132 Genova, Italy
    Curr Opin Hematol 12:457-62. 2005
    ..Published papers, as well as abstracts from European and American meetings, have been used together with original data...
  47. ncbi request reprint Outcome of laparoscopic splenectomy for malignant hematologic diseases
    Davide Cavaliere
    Divisione di Chirurgia Generale e Trapianti d Organo, Genoa, Italy
    Tumori 90:229-32. 2004
    ..The aim of this study was to assess whether the benign or malignant nature of hematological diseases may influence the outcome of laparoscopic splenectomy...
  48. ncbi request reprint Haemopoietic stem cell transplants: the impact of haemorrhagic complications
    Andrea Bacigalupo
    Department of Haematology, Bone Marrow Transplant Unit, Ospedale, San Martino, Genova, Italy
    Blood Rev 17:S6-10. 2003
    ..A total enrollment of 100 patients is anticipated, and preliminary data are expected at the end of 2003...
  49. ncbi request reprint Mesenchymal stem cells and haematopoietic stem cell transplantation
    Andrea Bacigalupo
    Divisione Ematologia, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Best Pract Res Clin Haematol 17:387-99. 2004
    ..With the expanding role of stem cell transplants in different areas of medicine, including cardiology and orthopaedics, MSCs may become very important in the next few years...
  50. doi request reprint A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia
    Gabriella Cirmena
    Department of Hematology, University of Genoa, V le Benedetto XV 6, 16132 Genoa, Italy
    Cancer Genet Cytogenet 183:105-8. 2008
    ..Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different...
  51. ncbi request reprint CTLA-4 expressed by chemoresistant, as well as untreated, myeloid leukaemia cells can be targeted with ligands to induce apoptosis
    Stefania Laurent
    Unit of Translational Research A, National Cancer Research Institute, Genova, Italy
    Br J Haematol 136:597-608. 2007
    ....
  52. pmc Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis
    Claudio Viscoli
    Istituto Nazionale per la Ricerca sul Cancro, Dipartimento di Oncologia, Biologia e Genetica, Genoa, Italy
    J Clin Microbiol 40:1496-9. 2002
    ..Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis...
  53. ncbi request reprint Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease
    Silvia Svegliati
    Dipartimento di Scienze Mediche e Chirurgiche, Sezione di Clinica Medica, Universita Politecnica delle Marche, Polo Didattico, Ancona, Italy
    Blood 110:237-41. 2007
    ..The biologic activity of these autoantibodies suggests a role in the development of fibrosis and argues for a common pathogenetic trait in ecGVDH and scleroderma phenotypes...
  54. ncbi request reprint Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes
    Rodrigo Martino
    Division of Clinical Hematology, Hopital de la Sant Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Blood 108:836-46. 2006
    ....
  55. ncbi request reprint Outcome of pregnancy and disease course among women with aplastic anemia treated with immunosuppression
    Andre Tichelli
    University Hospitals Basel, Hematology, Petersgraben 4, CH 4031 Basel, Switzerland
    Ann Intern Med 137:164-72. 2002
    ..The effects of pregnancy on aplastic anemia after immunosuppressive treatment and of aplastic anemia on the outcome of pregnancy have not been described...
  56. ncbi request reprint Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT
    Charles Crawley
    Clinical Haematology, Box 234, Addenbrookes Hospital, Cambridge, CB2 2QQ United Kingdom
    Blood 106:2969-76. 2005
    ..58). RIC allografts are feasible in CML in first or second CP. Since no other RIC regimen demonstrated superiority, Fd/Bu/ATG should be considered as baseline in future prospective trials...
  57. ncbi request reprint Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT)
    Bernd Hertenstein
    Hannover Medical School, Department of Hematology and Oncology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Haematologica 90:969-75. 2005
    ..DCL is an extremely rare complication of allogeneic SCT in which treatment attempts with chemotherapy and a second SCT are justified. Donors are not at an increased risk of developing hematologic malignancies...
  58. ncbi request reprint Relevance of bone marrow cell dose on allogeneic transplantation outcomes for patients with acute myeloid leukemia in first complete remission: results of a European survey
    Vanderson Rocha
    Hematopoietic Stem Cell Transplant Unit, Hopital Saint Louis, and Service d Hématologie, CHU Saint Antoine and European Data Management Office, Institut des Cordeliers, Paris, France
    J Clin Oncol 20:4324-30. 2002
    ..Bone marrow cell dose has been reported to be an important factor in alloBMT; however, its true impact on relapse incidence (RI), leukemia-free survival (LFS), and nonrelapse mortality (NRM) in a large cohort of patients is unknown...
  59. ncbi request reprint Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia: 3-year results from the EBMT randomized trial
    Norbert Schmitz
    Department of Hematology, AK St Georg, Lohmuehlenstrasse 5, 20099 Hamburg, Germany
    Haematologica 90:643-8. 2005
    ....
  60. ncbi request reprint Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
    ..The optimal MSC dose and frequency of administration to prevent or treat GVHD during allogeneic HSC transplantation should be evaluated further in phase II clinical trials...
  61. ncbi request reprint Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myelofibrosis with myeloid metaplasia
    Damiano Rondelli
    Stem Cell Transplant Program, Section Hematology Oncology, University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL 60607 7171, USA
    Blood 105:4115-9. 2005
    ..The use of RIC regimens in allogeneic stem cell transplantation results in prolonged survival in intermediate/high-risk MMM patients...
  62. ncbi request reprint Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia
    Eliane Gluckman
    Hospital Saint Louis, Paris, France
    Br J Haematol 119:1075-82. 2002
    ..We conclude that lenograstim support of immunosuppressive therapy might be used for patients with severe aplastic anaemia as it significantly enhances neutrophil recovery but does not modify the overall response and survival...
  63. ncbi request reprint Treatment of severe aplastic anemia with antilymphocyte globulin, cyclosporine and two different granulocyte colony-stimulating factor regimens: a GITMO prospective randomized study
    Anna Locasciulli
    Ematologia e Trapianto di Midollo, Ospedale San Camillo, Circonvallazione Gianicolense 87, 00152 Rome, Italy
    Haematologica 89:1054-61. 2004
    ..The aim of the present study was to test whether a higher dose of G-CSF (10 micro g/kg/day) would reduce these complications...
  64. ncbi request reprint Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
    Sebastian Giebel
    Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
    Blood 102:814-9. 2003
    ..These data indicate that natural killer (NK) cell alloreactivity is associated with better outcome after URD-HSC transplantation when ATG is used as part of GVHD prophylaxis...
  65. ncbi request reprint The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry
    Sherif S Farag
    The Ohio State University, Columbus, Ohio 43210, USA
    Biol Blood Marrow Transplant 12:876-84. 2006
    ..There were no differences in leukemia recurrence between the 4 groups. These results do not support the choice of an unrelated donor on the basis of KIR ligand mismatch determined from HLA typing...
  66. ncbi request reprint Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia
    Norbert Schmitz
    Department of Internal Medicine II, University of Kiel, Germany
    Blood 100:761-7. 2002
    ..Long-term observation of patients with different diseases and stages of disease is necessary to ultimately define the role of both sources of stem cells...
  67. ncbi request reprint Influence of donor/recipient sex matching on outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia
    Martin Stern
    University Hospital, Department of Hematology, Basel, Switzerland
    Transplantation 82:218-26. 2006
    ..An increased rejection of male grafts in female recipients is not reported for solid organ or stem cell transplants and the role of H-Y as transplantation antigen has been controversial...
  68. ncbi request reprint Unrelated donor haematopoietic cell transplantation after non-myeloablative conditioning for patients with high-risk multiple myeloma
    Benedetto Bruno
    Division of Hematology at the San Giovanni Battista Hospital, University of Torino, Torino, Italy
    Eur J Haematol 78:330-7. 2007
    ..We investigated the feasibility of unrelated donor non-myeloablative transplantation as either part of the initial treatment plan or as salvage treatment in heavily pretreated patients...
  69. ncbi request reprint Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT)
    Anna Locasciulli
    Ematologia e Trapianto di Midollo, Ospedale San Camillo, Circonvallazione Gianicolense 87, 00152 Roma Italy
    Haematologica 92:11-8. 2007
    ..The aim of this study was to assess the outcome of children and adults with AA treated in the last decade, and to determine whether results have improved in two sequential time periods,1991-1996 and 1997-2002...
  70. ncbi request reprint Reduced intensity conditioning with thiotepa, fludarabine, and melphalan is effective in advanced multiple myeloma
    Ignazio Majolino
    Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliera S Camillo Forlanini, Rome, Italy
    Leuk Lymphoma 48:759-66. 2007
    ..When used as first line treatment the results of transplantation appear even more encouraging...
  71. pmc Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia
    Hubert Schrezenmeier
    Institute of Clinical Transfusion Medicine and Immunogenetics, University of Ulm, Germany
    Blood 110:1397-400. 2007
    ..Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA...
  72. ncbi request reprint Donor lymphocyte infusions for the treatment of minimal residual disease in acute leukemia
    Alida Dominietto
    Blood 109:5063-4. 2007
  73. ncbi request reprint Intractable myoclonus associated with anti-GluR3 antibodies after allogeneic bone marrow transplantation
    Claudio Solaro
    Department of Neurology ASL3 genovese Genoa, Via Oliva 22 16154 Genoa, Italy
    Haematologica 91:ECR62. 2006
  74. ncbi request reprint Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
    Gerard Socie
    Service d Hématologie Greffe, and Institut National de la Santé et de la Recherche Médicale INSERM U728, Hospital Saint Louis, Paris, France
    Blood 109:2794-6. 2007
    ..These results emphasize the necessity of the current European randomized trial comparing IST with or without G-CSF and to alert physicians that adding G-CSF to IST is currently not standard treatment for SAA...
  75. ncbi request reprint Nonmyeloablative allogeneic stem cell transplantation in elderly patients with hematological malignancies: results from the GITMO (Gruppo Italiano Trapianto Midollo Osseo) multicenter prospective clinical trial
    Michele Falda
    Division of Hematology, San Giovanni Battista Hospital, Turin, Italy
    Am J Hematol 82:863-6. 2007
    ..The leukemic burden at time of transplant has proven to be the most important risk factor for the outcome...
  76. ncbi request reprint Donor lymphocyte infusion for relapsed chronic myelogenous leukemia: prognostic relevance of the initial cell dose
    Cesare Guglielmi
    Universita La Sapienza, Dipartimento di Biotecnologie Cellulari ed Ematologia, Unità TMO Allogenico Giuseppe Papa, Rome, Italy
    Blood 100:397-405. 2002
    ..Our results suggest that the first DLI dose should not exceed 0.2 x 10(8) mononuclear cells/kg...
  77. doi request reprint Cyclosporin A response and dependence in children with acquired aplastic anaemia: a multicentre retrospective study with long-term observation follow-up
    Paola Saracco
    Paediatric Haematology, University of Turin, Turin, Italy
    Br J Haematol 140:197-205. 2008
    ..This long-term follow-up of children with AAA shows that IST with a slow CyA tapering course is an effective treatment with a low-relapse rate in these cases...
  78. doi request reprint Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    Katarina Le Blanc
    Haematology Centre and Centre of Allogeneic Stem Cell Transplantation, Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Lancet 371:1579-86. 2008
    ..Mesenchymal stem cells modulate immune responses in vitro and in vivo. We aimed to assess whether mesenchymal stem cells could ameliorate GVHD after haemopoietic-stem-cell transplantation...
  79. ncbi request reprint Hormone replacement therapy and chronic graft-versus-host disease activity in women treated with bone marrow transplantation for hematologic malignancies
    Enrico Balleari
    Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy
    Ann N Y Acad Sci 966:187-92. 2002
    ..According to present data, HRT did not appear to influence the activity of cGVHD in young women who underwent ABMT for hematological malignancies. Therefore, we can safely propose this therapy for women with gonadal failure after ABMT...
  80. ncbi request reprint Introducing the special issue on allogeneic hematopoietic stem cell transplantation
    Andrea Bacigalupo
    Exp Hematol 31:841-3. 2003
  81. ncbi request reprint Molecular remission after myeloablative allogeneic stem cell transplantation predicts a better relapse-free survival in patients with multiple myeloma
    Paolo Corradini
    Hematology Bone Marrow Transplantation Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, 20133 Milan, Italy
    Blood 102:1927-9. 2003
    ..We believe that these findings could prompt the design of prospective studies to evaluate if the treatment of molecular disease can extend remission duration and survival...
  82. ncbi request reprint A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation
    Elisabetta Zino
    HLA Tissue Typing Laboratory, Immunohematology and Transfusion Medicine Service, San Raffaele Telethon Institue for Gene Therapy, Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H S Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Blood 103:1417-24. 2004
    ..64, P =.1). These data suggest that biologic characterization of in vivo alloreactivity can be a tool for definition of clinically relevant nonpermissive HLA mismatches for unrelated HSC transplantation...
  83. ncbi request reprint Epidemiology and risk factors for bloodstream infections after allogeneic hematopoietic stem cell transplantion
    Paola Cappellano
    Infectious Disease Unit, Federal University of Sao Paulo, Brazil
    New Microbiol 30:89-99. 2007
    ..001; OR 0.14; 95% CI, 0.05 - 0.40). By day 180 post-transplant, 87 (28%) out of 314 patients had died. The cumulative risk of death was significantly higher among patients with BSI than among other patients...
  84. doi request reprint WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
    Emilio Paolo Alessandrino
    Division of Hematology, University of Pavia, Fondazione Policlinico San Matteo, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Pavia, Italy
    Blood 112:895-902. 2008
    ..013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients...
  85. doi request reprint A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease
    Mary E D Flowers
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, USA
    Blood 112:2667-74. 2008
    ..001). ECP was generally well tolerated. These results suggest that ECP may have a steroid-sparing effect in the treatment of cGVHD. Clinical trials registered at www.ClinicalTrials.gov as NCT00054613...
  86. ncbi request reprint Aplastic anemia
    Seiji Kojima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 82:408-11. 2005
  87. ncbi request reprint T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia
    Andrea Bacigalupo
    Divisione Ematologia Ospedale San Martino, Italy
    Exp Hematol 33:819-27. 2005
    ..To compare the suppressive effect of mesenchymal stem cells (MSC), derived from normal individuals or severe aplastic anemia patients (SAA), on T-cell activation...
  88. ncbi request reprint Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 105:2066-73. 2005
    ..In most leukemias, both CD48 and NTBA were down-regulated. The correlation found between marker expression and susceptibility to lysis may reveal useful information for NK-based immunotherapy...
  89. ncbi request reprint Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population
    Carlo Dufour
    Department of Paediatric Haemato Oncology, Haematology Unit, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    Br J Haematol 126:682-5. 2004
    ..Homozygosity for 12 (CA) repeats of polymorphism VNDR 1349 of IFNG is strongly associated with the risk of AA in Caucasian subjects...
  90. ncbi request reprint Intra-bone marrow injection of bone marrow and cord blood cells: an alternative way of transplantation associated with a higher seeding efficiency
    Sandra Castello
    Centro Cellule Staminali e Terapia Cellularee, Universita di Pavia, Italy
    Exp Hematol 32:782-7. 2004
    ..However, the problem of seeding efficiency and homing is relevant especially when a limited number of stem cells is available. Intra-bone marrow (IBM) injection of bone marrow cells (BMCs) may overcome this problem...
  91. ncbi request reprint Retrospective comparison of bone marrow and granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for allogeneic stem cell transplantation using HLA identical sibling donors in myelodysplastic syndromes
    Philippe Guardiola
    Service de Greffe de Moelle, Hopital Saint Louis, Paris, France
    Blood 99:4370-8. 2002
    ....