Andrea Bacigalupo

Summary

Affiliation: San Martino Hospital
Country: Italy

Publications

  1. ncbi request reprint Factors influencing haematological recovery after allogeneic haemopoietic stem cell transplants: graft-versus-host disease, donor type, cytomegalovirus infections and cell dose
    A Dominietto
    Divisione Universitaria di Ematologia, Azienda Ospedaliera S Giovanni Battista, Torino, Italy
    Br J Haematol 112:219-27. 2001
  2. ncbi request reprint Third EBMT/AMGEN Workshop on reduced-intensity conditioning allogeneic haemopoietic stem cell transplants (RIC-HSCT), and panel consensus
    A Bacigalupo
    Divisione Ematologia 2, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 33:691-6. 2004
  3. ncbi request reprint Current results of bone marrow transplantation in patients with acquired severe aplastic anemia. Report of the European Group for Blood and Marrow transplantation. On behalf of the Working Party on Severe Aplastic Anemia of the European Group for Blood an
    A Bacigalupo
    Second Department of Haemotology, Ospedale San Martino, Servizio Radioterapia IST, Genoa, Italy
    Acta Haematol 103:19-25. 2000
  4. ncbi request reprint Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria
    A M Raiola
    Dipartimento di Ematologia, Ospedale San Martino, Largo R Benzi 10, 16132 Genoa, Italy
    Haematologica 85:59-62. 2000
  5. ncbi request reprint Bone marrow or peripheral blood as a source of stem cells for allogeneic transplants
    A Bacigalupo
    Divisione Ematologia II, Ospedale San Martino, Genova, Italy
    Curr Opin Hematol 7:343-7. 2000
  6. ncbi request reprint Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Sever
    A Bacigalupo
    Divisione Ematologia 2, Ospedale San Martino, Genova, Italy
    Blood 95:1931-4. 2000
  7. ncbi request reprint Mesenchymal stem cells and haematopoietic stem cell transplantation
    Andrea Bacigalupo
    Divisione Ematologia, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Best Pract Res Clin Haematol 17:387-99. 2004
  8. ncbi request reprint Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO)
    A Bacigalupo
    Ospedale San Martino, Genova, Italy
    Blood 98:2942-7. 2001
  9. ncbi request reprint Comparable TNF-alpha, IFN-gamma and GM-CSF production by purified normal marrow CD3 cells in response to horse anti-lymphocyte and rabbit antithymocyte globulin
    G Piaggio
    Sci Bio Department of Haematology 2, San Martino Hospital, Genova, Italy
    Eur J Haematol 60:240-4. 1998
  10. ncbi request reprint Bone marrow or peripheral blood as a source of stem cells for allogeneic transplantation
    Andrea Bacigalupo
    Divisione Ematologia 2 PAD 5 II, Ospedale San Martino, 16132 Genoa, Italy
    Haematologica 87:4-8. 2002

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Factors influencing haematological recovery after allogeneic haemopoietic stem cell transplants: graft-versus-host disease, donor type, cytomegalovirus infections and cell dose
    A Dominietto
    Divisione Universitaria di Ematologia, Azienda Ospedaliera S Giovanni Battista, Torino, Italy
    Br J Haematol 112:219-27. 2001
    ....
  2. ncbi request reprint Third EBMT/AMGEN Workshop on reduced-intensity conditioning allogeneic haemopoietic stem cell transplants (RIC-HSCT), and panel consensus
    A Bacigalupo
    Divisione Ematologia 2, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 33:691-6. 2004
    ..Most transplants were from HLA-identical siblings (77%), and used peripheral blood (90%) as a stem cell source. A consensus discussion on current evidence in RIC transplants is reported in this paper...
  3. ncbi request reprint Current results of bone marrow transplantation in patients with acquired severe aplastic anemia. Report of the European Group for Blood and Marrow transplantation. On behalf of the Working Party on Severe Aplastic Anemia of the European Group for Blood an
    A Bacigalupo
    Second Department of Haemotology, Ospedale San Martino, Servizio Radioterapia IST, Genoa, Italy
    Acta Haematol 103:19-25. 2000
    ..Transplants from twins are very successful as well. The risk of complications with alternative donor transplants is still high...
  4. ncbi request reprint Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria
    A M Raiola
    Dipartimento di Ematologia, Ospedale San Martino, Largo R Benzi 10, 16132 Genoa, Italy
    Haematologica 85:59-62. 2000
    ..Allogeneic bone marrow transplantation (BMT) may cure PNH. We reports here our experience of seven PNH patients who underwent allogeneic BMT...
  5. ncbi request reprint Bone marrow or peripheral blood as a source of stem cells for allogeneic transplants
    A Bacigalupo
    Divisione Ematologia II, Ospedale San Martino, Genova, Italy
    Curr Opin Hematol 7:343-7. 2000
    ..The general opinion is that peripheral blood grafts are indicated for patients with advanced disease, whereas for patients with early-phase disease the two sources may give comparable results...
  6. ncbi request reprint Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Sever
    A Bacigalupo
    Divisione Ematologia 2, Ospedale San Martino, Genova, Italy
    Blood 95:1931-4. 2000
    ..Early transplantation, also from alternative donors, may be warranted in patients with poor WBC response to G-CSF. (Blood. 2000;95:1931-1934)..
  7. ncbi request reprint Mesenchymal stem cells and haematopoietic stem cell transplantation
    Andrea Bacigalupo
    Divisione Ematologia, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Best Pract Res Clin Haematol 17:387-99. 2004
    ..With the expanding role of stem cell transplants in different areas of medicine, including cardiology and orthopaedics, MSCs may become very important in the next few years...
  8. ncbi request reprint Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO)
    A Bacigalupo
    Ospedale San Martino, Genova, Italy
    Blood 98:2942-7. 2001
    ....
  9. ncbi request reprint Comparable TNF-alpha, IFN-gamma and GM-CSF production by purified normal marrow CD3 cells in response to horse anti-lymphocyte and rabbit antithymocyte globulin
    G Piaggio
    Sci Bio Department of Haematology 2, San Martino Hospital, Genova, Italy
    Eur J Haematol 60:240-4. 1998
    ..This study shows that horse and rabbit derived ALG/ATG and PHA have a comparable in vitro priming effect on T cells: both agents should probably be tested for their clinical efficacy in SAA patients...
  10. ncbi request reprint Bone marrow or peripheral blood as a source of stem cells for allogeneic transplantation
    Andrea Bacigalupo
    Divisione Ematologia 2 PAD 5 II, Ospedale San Martino, 16132 Genoa, Italy
    Haematologica 87:4-8. 2002
    ..The aim of this report is to review available data on PB vs BM hematopoietic stem cell transplantation (HSCT). The discussion is restricted to unmanipulated HLA identical sibling transplants...
  11. ncbi request reprint Prophylactic antithymocyte globulin reduces the risk of chronic graft-versus-host disease in alternative-donor bone marrow transplants
    A Bacigalupo
    Divisione Ematologia II Ospedale San Martino, Genova, Italy
    Biol Blood Marrow Transplant 8:656-61. 2002
    ..We conclude that pretransplant ATG administration reduces the risk of acute and chronic GVHD, improves quality of life, and increases the likelihood that discontinuation of immunosuppressive therapy will be possible...
  12. ncbi request reprint Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation
    Andrea Bacigalupo
    Divisione di Ematologia, Ospedale San Martino, Genova
    Biol Blood Marrow Transplant 12:560-5. 2006
    ....
  13. ncbi request reprint Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation
    Andrea Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genoa, Italy
    Haematologica 89:1238-47. 2004
    ..The aims of this study were to determine whether these relationships still hold and whether the outcome of transplants is continuing to improve...
  14. doi request reprint Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning
    Anna Maria Raiola
    Divisione Ematologia e Trapianto di Midollo, IRCCS San Martino, Genova, Italy
    Biol Blood Marrow Transplant 19:117-22. 2013
    ..In conclusion, an MA conditioning regimen followed by haploidentical BMT with PT-CY results in a low risk of aGVHD and cGVHD and encouraging rates of TRM and DFS...
  15. ncbi request reprint Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors
    Marina Podesta
    Department of Hematology, 2nd Division, Pad 5, S Martino Hospital, Largo R Benzi 10, 16132 Genova, Italy
    J Biol Chem 280:5343-9. 2005
    ..These results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis...
  16. doi request reprint The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hematopoietic diseases
    Francesco Frassoni
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, Genova, Italy
    Best Pract Res Clin Haematol 23:237-44. 2010
    ..A suitable CBU was found for nearly every patient searching for a CBU. Therefore, IB CBT extends the possibility to transplant any patient for whom this approach represents the sole possibility of long-term survival...
  17. doi request reprint Leukaemia relapse after allogeneic transplants for acute myeloid leukaemia: predictive role of WT1 expression
    Sarah Pozzi
    Divisione Ematologia e Trapianto di Midollo, IRCCS San Martino IST, Genova, Italy
    Br J Haematol 160:503-9. 2013
    ..In conclusion, WT1 expression post-HSCT is a strong predictor of leukaemia relapse and survival in AML; WT1 may be used as a marker for early interventional therapy...
  18. doi request reprint CMV infection after transplant from cord blood compared to other alternative donors: the importance of donor-negative CMV serostatus
    Małgorzata Mikulska
    Division of Infectious Diseases, San Martino University Hospital, Genoa, Italy
    Biol Blood Marrow Transplant 18:92-9. 2012
    ..The duration and incidence of late CMV infection were similar when D-/R+ CBT were compared with D-/R+ alternative donor transplants...
  19. ncbi request reprint Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation
    Alessandra Larocca
    Divisione Ematologia, Ospedale San Gerardo, Monza, Milano, Italy
    Haematologica 91:935-40. 2006
    ..It is uncertain whether a boost of donor marrow or blood cells is beneficial in terms of trilineage recovery and non-relapse-related mortality (NRM)...
  20. pmc Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto, IRCCS San Martino IST, Genova, Italy
    Haematologica 97:1142-8. 2012
    ..The aim of this study was to test whether this currently also holds true for older patients with acquired aplastic anemia...
  21. ncbi request reprint Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation
    Alida Dominietto
    Dipartimento di Ematologia Ospedale San Martino, Genova, Italy
    Blood 100:3930-4. 2002
    ..02), and recipient age (P =.02). In conclusion, transplantation of high marrow cell dose is associated with reduced transplant mortality and improved survival and results in improved graft function both short and long term...
  22. doi request reprint Rituximab treatment for Epstein-Barr virus DNAemia after alternative-donor hematopoietic stem cell transplantation
    Stefania Coppoletta
    Division of Hematology and Bone Marrow Transplant, Ospedale San Martino, Genova, Italy
    Biol Blood Marrow Transplant 17:901-7. 2011
    ..Patients with increasing EBV copies despite rituximab therapy are at high risk for EBV PTLD and may be considered for alternative therapies...
  23. doi request reprint Allogeneic hematopoietic cell transplantation from unrelated donors in multiple myeloma: study from the Italian Bone Marrow Donor Registry
    Roberto Passera
    Divison of Nuclear Medicine 2, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy
    Biol Blood Marrow Transplant 19:940-8. 2013
    ..Long-term disease control remains challenging regardless of the conditioning. In the light of these results, prospective trials may be designed to better define the role of allografting from unrelated donors in myeloma...
  24. pmc Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia
    Carlo Dufour
    Haematology Unit, G Gaslini Children s Hospital, Genoa, Italy
    Haematologica 94:1743-7. 2009
    ....
  25. ncbi request reprint Laparoscopic lymph node biopsy in intra-abdominal lymphoma: high diagnostic accuracy achieved with a minimally invasive procedure
    Marco Casaccia
    Departments of General and Transplant Surgery, University of Genoa, San Martino Hospital, Genoa, Italy
    Surg Laparosc Endosc Percutan Tech 17:175-8. 2007
    ..LLB can be proposed as the procedure of choice to sample deep lymphatic tissues in patients with intra-abdominal lymphadenopathy at a very low morbidity rate and as an outpatient procedure in selected cases...
  26. pmc Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: a retrospective study from the EBMT-SAA Working Party
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Haematologica 95:976-82. 2010
    ..We analyzed the outcome of 100 patients with acquired severe aplastic anemia undergoing an alternative donor transplant, after immune suppressive therapy had failed...
  27. ncbi request reprint Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: a report from the EBMT-SAA Working Party
    A Bacigalupo
    Department of Hematology 2, Azienda Ospedaliera Universitaria San Martino, Largo Benzi, Genova, Italy
    Bone Marrow Transplant 36:947-50. 2005
    ..The significant risk of graft failure in patients 15 years or older may require modification of the conditioning regimen in adults...
  28. ncbi request reprint Unrelated donor haematopoietic cell transplantation after non-myeloablative conditioning for patients with high-risk multiple myeloma
    Benedetto Bruno
    Division of Hematology at the San Giovanni Battista Hospital, University of Torino, Torino, Italy
    Eur J Haematol 78:330-7. 2007
    ..We investigated the feasibility of unrelated donor non-myeloablative transplantation as either part of the initial treatment plan or as salvage treatment in heavily pretreated patients...
  29. doi request reprint Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study
    Francesco Frassoni
    Stem Cells and Cell Therapy Centre, San Martino Hospital, Genoa, Italy
    Lancet Oncol 9:831-9. 2008
    ..The aim of this phase I/II study was to establish the safety and efficacy of a new administration route (intrabone) for cord-blood cells, measured by the donor-derived neutrophil and platelet engraftment...
  30. ncbi request reprint Bone marrow transplantation from unrelated donors: the impact of mismatches with substitutions at position 116 of the human leukocyte antigen class I heavy chain
    G B Ferrara
    Laboratorio di Immunogenetica, Servizio di Epidemiologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 98:3150-5. 2001
    ..001), and 25% versus 31% (P =.4). In conclusion these data suggest that substitutions at position 116 of class I heavy chain increase the risk for acute GVHD and TRM in patients who receive transplanted bone marrow from unrelated donors...
  31. ncbi request reprint Female genital tract graft-versus-host disease following allogeneic bone marrow transplantation
    Simonetta Spinelli
    Dipartimento di Ematologia S Martino, Genova, Italy
    Haematologica 88:1163-8. 2003
    ..We tried to evaluate the incidence of genital tract involvement and whether there are specific risk factors...
  32. doi request reprint CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence
    Patrizia Piccioli
    Medical Oncology C, National Cancer Research Institute, Genoa, Italy
    Ann Hematol 89:613-8. 2010
    ..However, only recipient +49A>G polymorphism was retained as independent prognostic factor in a multivariate analysis, suggesting that the expression of CTLA-4 on the cells of recipient may be relevant for the clinical outcome of HSCT...
  33. doi request reprint Epidemiology of viral respiratory tract infections in an outpatient haematology facility
    Małgorzata Mikulska
    Division of Infectious Diseases, San Martino Hospital and University of Genoa, Largo R Benzi, 10 16132, Genoa, Italy
    Ann Hematol 93:669-76. 2014
    ..Thus, microbiological diagnosis and contact preventive measures are crucial. Rather than universal influenza prophylaxis, prompt diagnosis and treatment of only documented infections could be pursued...
  34. doi request reprint Endothelial colony-forming cells from patients with chronic myeloproliferative disorders lack the disease-specific molecular clonality marker
    Giovanna Piaggio
    Divisione Ematologia, Ospedale San Martino, Genova
    Blood 114:3127-30. 2009
    ....
  35. ncbi request reprint Improved outcome in young adults with de novo acute myeloid leukemia in first remission, undergoing an allogeneic bone marrow transplant
    D Vicente
    Dipartimento di Emato Oncologia, Ospedale San Martino, San Martino, Largo Benzi 10, 16132 Genoa, Italy
    Bone Marrow Transplant 40:349-54. 2007
    ..Improvement has come not only from changes in transplant procedures, but also from effective rescue of patients relapsing after transplant...
  36. doi request reprint Pre-emptive treatment of acute GVHD: a randomized multicenter trial of rabbit anti-thymocyte globulin, given on day+7 after alternative donor transplants
    A Bacigalupo
    Divisione Ematologia, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:385-91. 2010
    ..These results may represent a platform for risk-adapted post transplant immune modulation...
  37. ncbi request reprint Treatment of acute graft versus host disease with low dose-alternate day anti-thymocyte globulin
    Francesco Graziani
    Dipartimento di Ematologia, Ospedale San Martino, Genoa, Italy
    Haematologica 87:973-8. 2002
    ..In the present study we report on the use of low dose ATG (thymoglobuline, Sangstat) and steroids in 28 patients with moderate to severe acute GvHD...
  38. doi request reprint Matched and mismatched unrelated donor transplantation: is the outcome the same as for matched sibling donor transplantation?
    Andrea Bacigalupo
    1Istituto di Ricovero e Cura a Carattere Scientifico San Martino, Genova, Italy
    Hematology Am Soc Hematol Educ Program 2012:223-9. 2012
    ....
  39. ncbi request reprint Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti-thymocyte globulin
    Maria Teresa Van Lint
    Divisione Ematologia 2, Ospedale San Martino, 16132 Genoa, Italy
    Blood 107:4177-81. 2006
    ....
  40. ncbi request reprint Hormone replacement therapy and chronic graft-versus-host disease activity in women treated with bone marrow transplantation for hematologic malignancies
    Enrico Balleari
    Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy
    Ann N Y Acad Sci 966:187-92. 2002
    ..According to present data, HRT did not appear to influence the activity of cGVHD in young women who underwent ABMT for hematological malignancies. Therefore, we can safely propose this therapy for women with gonadal failure after ABMT...
  41. ncbi request reprint Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation
    Francesco Frassoni
    Centro Cellule Staminali e Terapia Cellulare, Dipartimento Emato Oncologia, Ospedale San Martino, 16132 Genova, Italy
    Blood 102:1138-41. 2003
    ....
  42. ncbi request reprint False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam
    Claudio Viscoli
    Infectious Disease Unit, National Institute for Cancer Research and University of Genoa, Genoa, Italy
    Clin Infect Dis 38:913-6. 2004
    ..Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results...
  43. doi request reprint Helical tomotherapy targeting total bone marrow after total body irradiation for patients with relapsed acute leukemia undergoing an allogeneic stem cell transplant
    Renzo Corvò
    Department of Radiation Oncology, University of Genoa and National Cancer Research Institute, Largo R Benzi 10, Genoa, Italy
    Radiother Oncol 98:382-6. 2011
    ..To report our clinical experience in planning and delivering total marrow irradiation (TMI) after total body irradiation (TBI) in patients with relapsed acute leukemia undergoing an allogeneic stem-cell transplant (SCT)...
  44. doi request reprint Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type
    A Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:458-63. 2010
    ..In conclusion, PMF patients undergoing an allogeneic HSCT may be scored according to the spleen size, transfusion history and donor type; this scoring system may be useful to discuss transplant strategies...
  45. doi request reprint Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD
    P Perfetti
    Divisione Ematologia e Trapianto di Midollo e Centro Trasfusionale San Martino, Genova, Italy
    Bone Marrow Transplant 42:609-17. 2008
    ..08). ECP is a treatment option for patients with steroid refractory aGVHD and should be considered early in the course of the disease...
  46. ncbi request reprint Low-dose fractionated total body irradiation (TBI) adversely affects prognosis of patients with leukemia receiving an HLA-matched allogeneic bone marrow transplant from an unrelated donor (UD-BMT)
    R Corvo
    UO Oncologia Radioterapica, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Bone Marrow Transplant 30:717-23. 2002
    ..04) and LRR (P = 0.03). These data indicate that a lower total dose of TBI appears significantly less effective in leukemia eradication and associated with worse overall survival when compared with a higher dose of radiation...
  47. doi request reprint Airway distensibility with lung inflation after allogeneic haematopoietic stem-cell transplantation
    Giovanni Barisione
    Fisiopatologia Respiratoria, IRCCS Azienda Ospedaliera Universitaria San Martino IST, Genoa, Italy
    Respir Physiol Neurobiol 184:80-5. 2012
    ..This effect seems to be related to an increase in lung stiffness and must be taken into account when interpreting lung function changes after HSCT...
  48. doi request reprint Galactomannan testing might be useful for early diagnosis of fusariosis
    Małgorzata Mikulska
    Division of Infectious Diseases, San Martino University Hospital, 16132 Genoa, Italy
    Diagn Microbiol Infect Dis 72:367-9. 2012
    ..Additionally, 3 Fusarium isolates tested positive for GM. Fusarium is another mold containing GM. GM might be useful for diagnosing fusariosis in high-risk patients...
  49. doi request reprint Acute bronchodilator responsiveness in bronchiolitis obliterans syndrome following hematopoietic stem cell transplantation
    Giovanni Barisione
    Unità Operativa Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria San Martino, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    Chest 139:633-9. 2011
    ..We studied whether nonconventional assessment of bronchodilation may help to detect physiologically meaningful airway responses missed by traditional criteria...
  50. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology, IRCCS Policlinico S Matteo, Pavia and Second Division of Hematology, Ospedale San Martino, Viale Golgi 19, 27100 Genoa, Italy
    Curr Opin Hematol 13:74-8. 2006
    ....
  51. ncbi request reprint Management of acute graft versus host disease (GvHD)
    Andrea Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genova, Italy
    Hematol J 5:189-96. 2004
    ..We have considerably reduced the risk of acute GvHD over the past three decades: we need to further improve these results, with the final goal of dissecting, if possible, the graft versus host from the graft versus tumor effect...
  52. ncbi request reprint Allogeneic hemopoietic stem cell transplants for patients with relapsed acute leukemia: long-term outcome
    A Bacigalupo
    Divisione di Ematologia 2, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 39:341-6. 2007
    ....
  53. ncbi request reprint Progenitor cells trapped in marrow filters can reduce GvHD and transplant mortality
    D Vicente
    Divisione Ematologia 2, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 38:111-7. 2006
    ..15). This study suggests that a significant proportion of LTC-IC is lost in the filters together with CFU-F. Recovery and add back of progenitors trapped in the filters may reduce GvHD and TRM...
  54. ncbi request reprint Pre-emptive therapy of acute graft-versus-host disease: a pilot study with antithymocyte globulin (ATG)
    A Bacigalupo
    Divisione Ematologia II, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Bone Marrow Transplant 28:1093-6. 2001
    ..08). This study indicates that early pre-emptive treatment of aGVHD in day +7 high risk patients is feasible and may lead to a reduction of aGVHD and TRM. This approach is being tested in a prospective randomized trial...
  55. ncbi request reprint Factors predicting response and graft-versus-host disease after donor lymphocyte infusions: a study on 593 infusions
    A M Raiola
    Dipartimento di Emato Oncologia, e Centro Trasfusionale, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 31:687-93. 2003
    ..The actuarial probability of treatment-related mortality was 9% for HLA identical siblings and 44% for alternative donor transplants (P=0.006). Response to DLI is predicted by tumor burden and is associated with GvHD and pancytopenia...
  56. ncbi request reprint Antithymocyte globulin for prevention of graft-versus-host disease
    Andrea Bacigalupo
    Divisione Ematologia II, Ospedale San Martino, 16132 Genova, Italy
    Curr Opin Hematol 12:457-62. 2005
    ..Published papers, as well as abstracts from European and American meetings, have been used together with original data...
  57. ncbi request reprint Coexistence of normal and clonal haemopoiesis in aplastic anaemia patients treated with immunosuppressive therapy
    G Piaggio
    Dipartimento di Ematologia, Ospedale S Martino, Genova, Italy
    Br J Haematol 107:505-11. 1999
    ..There was no significant clinical impact of these abnormalities on transfusion independence and survival at the median follow-up of 4 years...
  58. ncbi request reprint Engraftment of HLA-matched sibling hematopoietic stem cells after immunosuppressive conditioning regimen in patients with hematologic neoplasias
    A M Carella
    N O A, Hematology ABMT, Division of Hematology II, Ospedale S Martino, Genoa, Italy
    Haematologica 83:904-9. 1998
    ....
  59. ncbi request reprint Autografting with Ph-negative progenitors in patients at diagnosis of chronic myeloid leukemia induces a prolonged prevalence of Ph-negative hemopoiesis
    M Podesta
    Dipartimento di Ematologia Ospedale S Martino, Genova, Italy
    Exp Hematol 28:210-5. 2000
    ..The aim of this study is to examine changes that occur in the percentage of Ph-negative- and Ph-positive-committed progenitor cells and to determine the relationship between changes and clinical outcome...
  60. ncbi request reprint Interferon-alpha protects Philadelphia-negative progenitors from exhaustion in chronic myeloid leukemia patients with cytogenetic response
    F Frassoni
    Divisione Ematologia II, Ospedale San Martino, Genova, Italy
    Hematol J 2:26-32. 2001
    ..Such exhaustion could reflect a suppressive effect of the Philadelphia positive clone expansion and/or be induced by Interferon-alpha treatment...
  61. ncbi request reprint Refractory Evans' syndrome treated with allogeneic SCT followed by DLI. Demonstration of a graft-versus-autoimmunity effect
    A M Marmont
    Department of Hemato Oncology, St Martino s Hospital, Genova, Italy
    Bone Marrow Transplant 31:399-402. 2003
    ..Long-term FU is necessary before claiming that allogeneic stem cell transplantation (SCT) is capable of curing an autoimmune blood disease. However, there is evidence for a graft-versus-autoimmunity effect in this case...
  62. ncbi request reprint Unrelated donor marrow transplantation: an update of the experience of the Italian Bone Marrow Transplant Group (GITMO)
    G Dini
    U O Ematologia Oncologia Pediatrica, IRCCS G Gaslini, Genova, Italy
    Haematologica 85:30-6. 2000
    ..The long time required for the search is the major obstacle to the success of this programme. This suggests that early transplant and a decrease in TRM could further improve these encouraging results...
  63. ncbi request reprint A revised day +7 predictive score for transplant-related mortality: serum cholinesterase, total protein, blood urea nitrogen, gamma glutamyl transferase, donor type and cell dose
    M P Sormani
    Unitá Epidemiologia Clinica, Istituto Scientifio Tumori, Genoa, Italy
    Bone Marrow Transplant 32:205-11. 2003
    ..The score for single patients can be calculated on the web site http://213.26.110.20/lrm/day_seven_score.html...
  64. ncbi request reprint Laparoscopic splenectomy for hematological diseases
    P Torelli
    Department of General Surgery and Transplant Surgery, University of Genoa, San Martino Hospital, Largo R Benzi 10, Genoa 16100, Italy
    Surg Endosc 16:965-71. 2002
    ....
  65. ncbi request reprint Reduced intensity thiotepa-cyclophosphamide conditioning for allogeneic haemopoietic stem cell transplants (HSCT) in patients up to 60 years of age
    A M Raiola
    Dipartimento di Ematologia DEMA, Ospedale San Martino, Dipartimento Medicina Interna DIMI and Cattedra Medicina Legale, Univesita, Genova, Italy
    Br J Haematol 109:716-21. 2000
    ....
  66. ncbi request reprint Effect of centre on outcome of bone-marrow transplantation for acute myeloid leukaemia. Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation
    F Frassoni
    Divisione Ematologia II, Ospedale San Martino, Genova, Italy
    Lancet 355:1393-8. 2000
    ..There is increasing pressure for the recognition and replication of good clinical practice. We undertook a study to assess the variability in outcome of allogeneic bone-marrow transplantation among major European centres...
  67. ncbi request reprint Conventional hematopoietic stem cell transplants from identical or alternative donors are feasible in recipients relapsing after an autograft
    C di Grazia
    Dipartmento di Ematologia, Ospedale San Martino, Genoa, Italy
    Haematologica 86:646-51. 2001
    ....
  68. doi request reprint Late pulmonary complications after allogeneic hematopoietic stem cell transplantation: diagnosis, monitoring, prevention, and treatment
    Andrea Bacigalupo
    Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Semin Hematol 49:15-24. 2012
    ..It would be also important to improve understanding of the biological heterogeneity of this devastating complication after allo-HSCT...
  69. pmc Defining the intensity of conditioning regimens: working definitions
    Andrea Bacigalupo
    San Martino Hospital, Genoa, Italy
    Biol Blood Marrow Transplant 15:1628-33. 2009
    ..Standardized classification of conditioning regimen intensities will allow comparison across studies and interpretation of study results...
  70. ncbi request reprint Management of acute graft-versus-host disease
    Andrea Bacigalupo
    Divisione Ematologia e Trapianto di Midollo, Ospedale San Martino, Genova, Italy
    Br J Haematol 137:87-98. 2007
    ..Acute GvHD is complicated by severe immunodeficiency causing life-threatening infections. To date, GvHD has not been differentiated from the graft-versus-leukaemia effect. The present review will discuss some of these aspects...
  71. ncbi request reprint Clinical scale ex vivo expansion of cord blood-derived outgrowth endothelial progenitor cells is associated with high incidence of karyotype aberrations
    Mirko Corselli
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, Genova, Italy
    Exp Hematol 36:340-9. 2008
    ..In this study, we evaluated the expansion potential of CB EPCs together with their phenotypic, functional, and chromosomal stability over time...
  72. ncbi request reprint Outcome of laparoscopic splenectomy for malignant hematologic diseases
    Davide Cavaliere
    Divisione di Chirurgia Generale e Trapianti d Organo, Genoa, Italy
    Tumori 90:229-32. 2004
    ..The aim of this study was to assess whether the benign or malignant nature of hematological diseases may influence the outcome of laparoscopic splenectomy...
  73. ncbi request reprint Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice
    Marina Podesta
    Department of Hematology, 2nd Division, S Martino Hospital, Genoa, Italy
    FASEB J 17:310-2. 2003
    ....
  74. ncbi request reprint Second EBMT Workshop on reduced intensity allogeneic hemopoietic stem cell transplants (RI-HSCT)
    A Bacigalupo
    Divisione Ematologia II Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 29:191-5. 2002
    ..The term mini- or micro-transplant is probably misleading and one should refer to this procedure as an allogeneic HSCT and further classify the intensity of the conditioning regimen...
  75. doi request reprint Risk factors for invasive aspergillosis and related mortality in recipients of allogeneic SCT from alternative donors: an analysis of 306 patients
    M Mikulska
    Division of Infectious Diseases, San Martino University Hospital and University of Genoa, Genoa, Italy
    Bone Marrow Transplant 44:361-70. 2009
    ..The outcome of IA depends on the severity of immunodeficiency and the status of the underlying disease...
  76. ncbi request reprint Molecular and clinical remissions in multiple myeloma: role of autologous and allogeneic transplantation of hematopoietic cells
    P Corradini
    Dipartimento di Medicina ed Oncologia Sperimentale, Azienda Ospedaliera San Giovanni Battista Divisione Universitaria di Ematologia, Torino, Italy
    J Clin Oncol 17:208-15. 1999
    ..To describe molecular monitoring of minimal residual disease in patients with myeloma who have achieved complete remission (CR) after autologous or allogeneic transplantation of hematopoietic cells...
  77. ncbi request reprint In vitro effect of stem cell factor on colony growth from acquired severe aplastic anemia
    A Bacigalupo
    Divisione di Ematologia, Ospedale San Martino, Genova, Italy
    Stem Cells 11:175-9. 1993
    ..When PB cells were plated directly in the presence of GM-CSF there was no colony formation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  78. ncbi request reprint Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling
    P Anserini
    Centro Infertilità, Dipartimento di Ostetricia e Ginecologia, Universita di Genova, Genova, Italy
    Bone Marrow Transplant 30:447-51. 2002
    ..These results have implications for semen sample timing before and after BMT and underline a need to collect further data through prospective multi-center studies...
  79. ncbi request reprint Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis
    E Capello
    Department of Neurological Sciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, I 16132, Genoa, Italy
    Neurol Sci 26:S200-3. 2005
    ..These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving MS cases unresponsive to conventional therapies...
  80. ncbi request reprint Stem cell transplantation for chronic myeloid leukemia (CML): current indications and perspectives
    Andrea Bacigalupo
    Divisione Ematologia 2, Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Curr Cancer Drug Targets 13:775-8. 2013
    ..In conclusion, allogeneic SCT remains a therapeutic option for selected patients with CML and is currently being integrated with the use of TKIs both before and after transplantation. ..
  81. doi request reprint Extracorporeal photopheresis for the treatment of acute and chronic graft-versus-host disease in adults and children: best practice recommendations from an Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and Italian Group for Bone Marrow Tra
    Luca Pierelli
    Servizio di Immunoematologia e Medicina Trasfusionale, A O San Camillo Forlanini, Roma, Italy Università La Sapienza, Roma, Italy Servizio Trasfusionale, UOS Aferesi e nuove tecnologie trasfusionali, A O San Gerardo, Monza, Italy Unità di Ematologia, Divisione di Medicina Interna, Ospedale C Massaia, Asti, Italy Clinica di Oncoematologia Pediatrica, Universita di Padova, Padova, Italy Servizio di Immunoematologia e Trasfusionale, Unità di Terapia Cellulare, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy UO Immunoematologia, A O Universitaria Pisana, Pisa, Italy Divisione Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Genova, Italy Dipartimento of Oncologia Ematologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Pavia, Italy Università di Pavia, Pavia, Italy Centro Trasfusionale, Ospedale San Martino, Genova, Italy UO Ematologia, A O Careggi and Università di Firenze, Firenze, Italy
    Transfusion 53:2340-52. 2013
    ..Consensus-based recommendations ameliorate the appropriateness in daily clinical practice and, in turn, optimize the use of health care resources...
  82. doi request reprint Foscarnet in the management of cytomegalovirus infections in hematopoietic stem cell transplant patients
    Andrea Bacigalupo
    Department of Hematology, Ospedale San Martino, Genova, Italy
    Expert Rev Anti Infect Ther 10:1249-64. 2012
    ..In patients receiving hematopoietic stem cell transplantation, it has proven efficacy when used pre-emptively to treat CMV reactivation, as an alternative to and also in combination with ganciclovir...
  83. ncbi request reprint Haemopoietic stem cell transplants: the impact of haemorrhagic complications
    Andrea Bacigalupo
    Department of Haematology, Bone Marrow Transplant Unit, Ospedale, San Martino, Genova, Italy
    Blood Rev 17:S6-10. 2003
    ..A total enrollment of 100 patients is anticipated, and preliminary data are expected at the end of 2003...
  84. ncbi request reprint Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients
    Carlo Dufour
    Hematology Unit, Department of Pediatric Hemato Oncology, Giannina Gaslini Children s Hospital, Genoa, Italy
    Haematologica 90:1027-31. 2005
    ..We assessed whether, in a Caucasian population, low or null activity polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 were associated with the risk of developing aplastic anemia and with the response to immunosuppressive therapy...
  85. ncbi request reprint Adding low-dose gemtuzumab ozogamicin to fludarabine, Ara-C and idarubicin (MY-FLAI) may improve disease-free and overall survival in elderly patients with non-M3 acute myeloid leukaemia: results of a prospective, pilot, multi-centre trial and comparison
    Marino Clavio
    Department of Haematology and Oncology, University of Genova and S Martino Hospital, Genova, Italy
    Br J Haematol 138:186-95. 2007
    ..This GO-based induction chemotherapy has a good toxicity profile. In keeping with a recent prospective randomised trial, the addition of GO seems to prolong disease-free survival...
  86. ncbi request reprint Fludarabine, ARA-C, idarubicin and G-CSF (FLAG-Ida), high dose ARA-C and early stem cell transplant. A feasable and effective therapeutic strategy for de novo AML patients
    M Clavio
    Dept of Hematology and Oncology DEMO, Azienda Ospedale San Martino e Cliniche Universitarie Convenzionate, Genova, Italy
    J Exp Clin Cancer Res 21:481-7. 2002
    ..5 x 10(9)/l) was 17 days (range 10-28) and 50 x 10(9)/l platelets were reached at a median of 17 days (12-38). In conclusion FLAG-Ida regimen is effective, low toxic and improves feasibility of stem cell transplant...
  87. ncbi request reprint Catastrophic relapse of Evans syndrome five years after allogeneic BMT notwithstanding full donor chimerism. Terminal hemolytic-uremic syndrome
    A M Marmont
    Division of Hematology and Stem Cell Transplantation Center, Istituto G Gaslini, Genova, Italy
    Autoimmunity 39:505-11. 2006
    ..The postulated graft-versus-autoimmunity (GVA) effect was apparently not sufficient to eradicate autoimmunity in this patient...
  88. ncbi request reprint Modified in vitro conditions for cord blood-derived long-term culture-initiating cells
    M Podesta
    Divisione di Ematologia 2, Ospedale S Martino, Genova, Italy
    Exp Hematol 29:309-14. 2001
    ..The aim of this study was to compare the in vitro growth of cord blood-derived progenitors with that of bone marrow and peripheral blood...
  89. ncbi request reprint Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: efficacy and side effects
    A Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 35:225-31. 2005
    ..ALG/ATG should be used with caution, and the negative consequences must be understood and possibly prevented...
  90. ncbi request reprint Treatment of aplastic anaemia (AA) with antilymphocyte globulin (ALG) and methylprednisolone (MPred) with or without androgens: a randomized trial from the EBMT SAA working party
    A Bacigalupo
    Divisione Ematologia 2, Ospedale San Martino, Genova, Italy
    Br J Haematol 83:145-51. 1993
    ..The reversible side-effects warrant the use of androgens as an adjunct to the first course of ALG in females with severe AA...
  91. ncbi request reprint Adult advanced chronic lymphocytic leukemia: computational analysis of whole-body CT documents a bone structure alteration
    Francesco Fiz
    From the Departments of Nuclear Medicine Unit F Fiz, R P, F B, S M, G B, G S, Hematology M Miglino, Hematology and Bone Marrow Transplantation A B, and Epidemiology P B, IRCCS San Martino IST, University of Genoa, L go R Benzi 10, 16132 Genoa, Italy CNR Institute of Molecular Bioimaging and Physiology, Milan, Section of Genoa, Genoa, Italy C M Nuclear Medicine Unit, U Parini Hospital, Aosta, Italy M Massollo Department of Mathematics, University of Genoa, Genoa, Italy C C, M P and Stem Cell Laboratory, IRCCS Pediatric Institute G Gaslini, Genoa, Italy F Frassoni
    Radiology 271:805-13. 2014
    ....
  92. doi request reprint Supportive care with art therapy, for patients in isolation during stem cell transplant
    Alessandra Agnese
    Department of Hematology II, University Hospital San Martino, Genova, Italy
    Palliat Support Care 10:91-8. 2012
    ....
  93. pmc Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis
    Claudio Viscoli
    Istituto Nazionale per la Ricerca sul Cancro, Dipartimento di Oncologia, Biologia e Genetica, Genoa, Italy
    J Clin Microbiol 40:1496-9. 2002
    ..Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis...
  94. ncbi request reprint Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia
    A Bacigalupo
    Department of Hematology, Osp San Martino, Genova, Italy
    Leukemia 17:1722. 2003
  95. pmc Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells
    C Vitale
    Dipartimento di Medicina Sperimentale and Dipartimento di Oncologia, Biologia e Genetica, Universita degli Studi di Genova, 16132 Genova, Italy
    Proc Natl Acad Sci U S A 98:5764-9. 2001
    ..These studies provide the rationale for new therapeutic approaches in myeloid leukemias by using both chemotherapy and apoptosis-inducing mAbs...
  96. ncbi request reprint The polymorphisms -318C>T in the promoter and 49A>G in exon 1 of CTLA4 and the risk of aplastic anemia in a Caucasian population
    J Svahn
    Hematology Unit, Department of Pediatric Hemato Oncology, G Gaslini Children s Hospital, Genova, Italy
    Bone Marrow Transplant 35:S89-92. 2005
    ..This study indicates that the polymorphisms -318C > T and 49A > G of CTLA4 do not affect the risk of developing AA and do not influence the response to immunosuppression...
  97. ncbi request reprint Radiotherapy after high-dose chemotherapy followed by autologous bone marrow transplantation in patients with intermediate or high-grade non-Hodgkin's lymphoma
    S Barra
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Tumori 82:335-8. 1996
    ..In our opinion, radiotherapy is an effective treatment after HDCT+ABMT and may have a role in a prospective multidisciplinary approach...
  98. pmc Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells
    C Vitale
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Proc Natl Acad Sci U S A 96:15091-6. 1999
    ..Thus, the present study suggests that p75/AIRM1 and CD33 may play a regulatory role in normal myelopoiesis and may be viewed as suitable target molecules to counteract the proliferation/survival of chronic myeloid leukemias...
  99. ncbi request reprint Alternating chemoradiotherapy versus partly accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck: results from a phase III randomized trial
    R Corvo
    Oncologia Radioterapica, National Cancer Research Institute, Genoa, Italy
    Cancer 92:2856-67. 2001
    ..The purpose of this randomized trial was to compare the same chemoradiotherapy approach with high-total-dose partly accelerated radiotherapy...
  100. doi request reprint Changes in lung volumes and airway responsiveness following haematopoietic stem cell transplantation
    G Barisione
    Dept of Preventive and Occupational Medicine Laboratory of Respiratory Pathophysiology, San Marino University, Genova, Italy
    Eur Respir J 32:1576-82. 2008
    ....
  101. ncbi request reprint Long term complete remission of severe nephrotic syndrome secondary to diffuse global (IV-G) lupus nephritis following autologous, haematopoietic peripheral stem (CD34+) cell transplantation
    A M Marmont
    Division of Haematology and Stem Cell Transplantation Centre, S Martino s Hospital, Genoa, Italy
    Lupus 15:44-6. 2006
    ..Five years later the patient is in complete clinical and immunologic remission. The indications for ASCT and its mechanism of action are briefly discussed...