Research Topics
Species | M SalvadoriSummaryCountry: Italy Publications
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Publications
Donor characteristics can influence overall transplant activities: the Italian experienceAlberto Rosati
Renal Unit, Careggi University Hospital, Florence, Italy
J Nephrol 16:342-9. 2003....
Long-term administration of enteric-coated mycophenolate sodium in kidney transplant patientsM Salvadori
Azienda Ospedaliera Careggi, Florence, Italy
Transplant Proc 37:909-11. 2005....
Donor characteristics can influence overall transplant activities: the Italian experienceE Bertoni
Renal Unit, Dept of Renal Transplantation, Careggi University Hospital, Firenze, Italy
Ann Transplant 9:17-8. 2004....
Excellent outcome of renal transplantation using single old kidneys in old recipientsE Bertoni
Renal Unit, Dept of Renal Transplantation, Careggi University Hospital, Firenze, Italy
Ann Transplant 9:25-6. 2004....
Enteric-coated mycophenolate sodium is therapeutically equivalent to mycophenolate mofetil in de novo renal transplant patientsMaurizio Salvadori
Azienda Ospedaliera Careggi, Florence, Italy
Am J Transplant 4:231-6. 2004..0% of EC-MPS patients and 19.5% of MMF patients required dose changes for GI adverse events (p=ns). Enteric-coated-MPS 720 mg b.i.d. is therapeutically equivalent to MMF 1000 mg b.i.d. with a comparable safety profile...
Younger dialytic patients are really at risk to be not transplanted. The Tuscany experienceE Bertoni
Renal Unit, Dept of Renal Transplantation, Careggi University Hospital, Firenze, Italy
Ann Transplant 9:27-8. 2004..This unfair condition need to be corrected either by promoting living donation, either increasing cadaveric donation from younger donors...
Post-transplant diabetes mellitusMaurizio Salvadori
Renal Unit, Careggi University Hospital, Florence, Italy
J Nephrol 16:626-34. 2003....
[Side effects and toxicity of immunosuppressive agents]M Salvadori
Unita Operativa di Nefrologia, Dialisi e Trapianto Renale, Ospedale di Careggi, Firenze
G Ital Nefrol 20:490-502. 2003..New drug trials have been undertaken to find immunosuppressive drugs with lower toxicity and less negative impact on bone and cardiovascular function. In preliminary studies, Sirolimus seems to have a less severe side effects profile...
[Survival of the renal transplant: data from international registries]M Salvadori
Unita Operativa Nefrologia, Dialisi e Trapianto Renale, Ospedale Careggi, Firenze
G Ital Nefrol 21:S10-8. 2004..In recent studies, one year renal function proved to be the best predictor of poor outcome. Several other factors, such as recipient hypertension, dyslipidemia, smoking and recipient compliance influence graft survival...
Efficacy and safety of Palmaz stent implantation in the treatment of renal artery stenosis in renal transplantationM Salvadori
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 37:1047-8. 2005..This method, which has low procedure costs and an extremely low complication rate has proved to be safe and to offer the potential of preserving luminal patency, improving the long-term efficacy of percutaneous angioplasty...
Impact of mycophenolate mofetil dose posttransplantation on 12-month renal function: analysis of the MOST databaseM Salvadori
U O di Nefrologia dei Trapianti, Policlinico di Careggi, Firenze, Italia
Transplant Proc 37:2464-6. 2005..Mycophenolate mofetil (MMF) has greatly reduced the risk of acute rejection episodes (ARE) after renal transplantation, but dose reductions/withdrawals could jeopardize long-term results...
Immunosuppression in renal transplantation: viral diseases and chronic allograft nephropathyM Salvadori
Renal Unit, Department of Renal Transplantation, Careggi University Hospital, Florence, Italy
Transplant Proc 37:2500-1. 2005..Indeed HCV is likely to determine immunologically mediated nephritis in the transplanted kidney as well in the native one...
FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and AustralasiaM Salvadori
Careggi Hospital, Division of Nephrology, Florence, Italy
Am J Transplant 6:2912-21. 2006..0 mg did not support a 50% reduction in cyclosporine exposure. The cause of macular edema cases and lower creatinine clearance with FTY720 in de novo transplantation needs further investigation...
Long-term administration of enteric-coated mycophenolate sodium (EC-MPS; myfortic) is safe in kidney transplant patientsM Salvadori
Renal Unit, Careggi University Hospital, Florence, Italy
Clin Nephrol 66:112-9. 2006..We report the first long-term safety and efficacy data on EC-MPS when administered for up to 3 years post transplant...
Hyperhomocysteinemia in renal transplant patients: an independent factor of cardiovascular diseaseE Bertoni
Renal Unit, Careggi University Hospital, Florence, Italy
J Nephrol 14:36-42. 2001..The authors conclude that high Hcy levels could be a relevant covariate for cardiovascular disease in transplant patients and they suggest that vitamin supplementation be recommended as a part of therapy...
Estimated one-year glomerular filtration rate is the best predictor of long-term graft function following renal transplantMaurizio Salvadori
Renal Unit, Careggi University Hospital, Florence, Tuscany, Italy
Transplantation 81:202-6. 2006..The objective of this study was to assess the effect of various demographic and transplant-related parameters on renal function via GFR at 1 year and 5 years post transplantation, using univariate and multivariate data analysis...
One-year posttransplant renal function is a strong predictor of long-term kidney function: results from the Neoral-MOST Observational StudyM Salvadori
Department of Renal Transplantation, Careggi University Hospital, Viale Pieraccini 18, Tuscany, Florence 50139, Italy
Transplant Proc 35:2863-7. 2003..The effects of delayed graft function and acute rejection appear to be limited to their influence on serum creatinine at 1 year, whereas donor type and previous graft predominantly affect later stages of graft life...
Chronic kidney disease is still present after renal transplantation with excellent functionE Bertoni
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 38:1024-5. 2006..Markers of endothelial dysfunction were largely abnormal, a condition that could predispose to cardiovascular events...
Low 1-year cyclosporine microemulsion doses are associated with better 5-year renal graft function: an insight from MOST, a multinational observational studyM Salvadori
Renal Unit, Careggi University Hospital, Florence, Tuscany, Italy
Transplant Proc 38:1010-3. 2006..CONCLUSIONS: Compared to higher doses, CsA-ME <3 mg/kg/d at year 1 posttransplantation is associated with increased preservation of renal allograft function at year 5...
Donor characteristics can influence transplant activities and the access to transplant for some age groupsA Rosati
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 37:2423-4. 2005..7% for the 46 to 55 age group, and 88.5% for the over 55 years group (P = .0029). Ethical considerations suggest new approaches of innovative promotion of living donor transplants and a revision of organ allocation criteria...
Lower homocysteine levels in renal transplant recipients treated with everolimus: a possible link with a decreased cardiovascular risk?S Farsetti
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 42:1381-2. 2010..This preliminary study demonstrates a favorable impact of everolimus on a marker of atherothrombosis which is associated with a worse vascular prognosis...
Factors influencing the glomerular filtration rate increase after cadaveric renal transplantation: a multivariate analysisE Bertoni
Renal Unit and Thrombosis Center, Department of Renal Transplantation, Careggi University Hospital, Florence, Italy
Transplant Proc 34:3108-12. 2002
High cysteine levels in renal transplant recipients: relationship with hyperhomocysteinemia and 5,10-MTHFR polymorphismR Marcucci
Istituto di Clinica Medica Generale e Cardiologia, Universita di Firenze, and Renal Unit, Careggi Hospital, Florence, Italy
Transplantation 71:746-51. 2001....
Autoantibodies against oxidized LDL in chronic renal failure: role of renal function, diet, and lipidsF Bergesio
Nephrology and Dialysis Units, Azienda Ospedaliera Careggi, Florence, Italy
Nephron 87:127-33. 2001..Vegan diet, by reducing LP, TG, and Lp(a), is supposed to decrease the risk of cardiovascular disease and worth being reconsidered as an alternative effective therapeutic tool in patients with advanced CRF...
Superior efficacy of enteric-coated mycophenolate vs mycophenolate mofetil in de novo transplant recipients: pooled analysisM Salvadori
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 42:1325-8. 2010..In conclusion, this pooled analysis documents a substantial improvement in efficacy in de novo RTx recipients receiving EC-MPS vs MMF with concomitant cyclosporine and steroid therapy...
Subcutaneous nodules and infectious complications in renal allograft recipientsL Caroti
Renal Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
Transplant Proc 42:1146-7. 2010..Subcutaneous nodules may reflect a systemic infectious pathology. In some cases, the investigation of cutaneous lesions is important to reach a definitive diagnosis for possible future disseminated infections...
Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipientsL Moscarelli
Renal Unit Careggi University Hospital, Florence, Italy
Clin Nephrol 75:440-50. 2011....
Venous thromboembolism in renal transplant recipients: high rate of recurrenceM Zanazzi
Renal Unit, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
Transplant Proc 37:2493-4. 2005..0001). Our data outline the high risk of recurrence in renal transplant recipients. Strategies for recurrence prevention are needed taking into account the high bleeding risk of anticoagulants in renal transplant patients...
[Unusual infections in transplantation]E Bertoni
Unita' Operativa Nefrologia Dialisi Trapianto Renale, Ospedale Careggi, Firenze
G Ital Nefrol 19:560-70. 2002....
Kidney graft survival rates do not improve by era: the impact of the age factorP Carta
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 42:2218-9. 2010..The graft survival rate in period B was worse than in period A, although the acute rejection rate was lower. The older age of both donors and recipients in period B seemed to be an important cause of worse outcomes...
Conversion from calcineurin inhibitors to everolimus with low-dose cyclosporine in renal transplant recipients with squamous cell carcinoma of the skinL Caroti
Renal Unit, AOU Careggi, Florence, Italy
Transplant Proc 44:1926-7. 2012..In the case of preexisting deterioration of renal function or significant proteinuria, conversion to EVR should be carefully evaluated...
Contrast-enhanced ultrasound assessment of complex cystic lesions in renal transplant recipients with acquired cystic kidney disease: preliminary experienceN Paudice
Nephrology Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 44:1928-9. 2012..This preliminary study characterized solid nodules and BIII lesions for further evaluation by CT. CEUS seems to correctly characterize BI and BII cysts that are not clearly defined by standard ultrasound...
Fate of kidneys from the same donor grafted into different recipients: do they behave similarly and are they influenced by donor-related factors?E Bertoni
Renal Unit, Careggi University Hospital, Florence, Italy
J Nephrol 13:150-4. 2000..The fate of paired kidneys might be similar and could therefore reflect the influence of donor-related factors on graft outcome...
Keratinocyte cancer prevention with ACE inhibitors, angiotensin receptor blockers or their combination in renal transplant recipientsL Moscarelli
Renal Unit Careggi University Hospital, Florence, Italy
Clin Nephrol 73:439-45. 2010..The observation that angiotensin II is a potent angiogenic and growth factor raises the possibility that blocking its effects could reduce the incidence of skin cancer...
Blood rheology and renal transplantation: an intriguing relationship for assessing cardiovascular riskM Zanazzi
Renal Unit, Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Transplant Proc 42:1383-4. 2010..5). Fibrinogen, but not hematocrit, significantly increased in RTRs (P = .001). This preliminary study provides evidence of an altered hemorheologic profile in RTRs...
Donors positive for hepatitis B core antibodies in nonliver transplantationsM Salvadori
Department of Renal Transplantation, Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 43:277-9. 2011..Our data show a 15%-20% incidence of HBcAb-positive donors, as in other European countries. The 1-year graft outcomes are good, with a 3% seroconversion rate to HB surface antigen...
Case report: HIV infection from a kidney transplantB Borchi
Infectious Disease Department, Careggi University and Hospital, Firenze, Italy
Transplant Proc 42:2267-9. 2010..We finally obtained a stable clinical and viroimmunologic condition. The transmission of multiresistant strains of HIV from unknown patients requires complex multidisciplinary management...
Reticulated platelets and platelet reactivity in renal transplant recipients receiving antiplatelet therapyM Zanazzi
Renal Unit, Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence and Careggi University Hospital, Florence, Italy
Transplant Proc 42:1156-7. 2010..6%) of whom were not receiving acetylsalicylic acid (ASA) therapy (group A) and 39 (43.3%) who were receiving ASA therapy, 100 mg (group B), and in 60 healthy controls (group C)...
Preemptive therapy for the prevention of cytomegalovirus disease in renal transplant recipients: our preliminary experienceN Paudice
Renal Unit, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
Transplant Proc 41:1204-6. 2009..We report our preliminary evaluation of the efficacy and security of preemptive therapy to manage renal transplant recipients with evidence of active CMV replication...
Nodular macroglossia with combined light chain and beta-2 microglobulin deposition in a long-term dialysis patientS Bandini
Department of Nephrology, Careggi Hospital, Florence, Italy
J Nephrol 14:128-31. 2001..In all cases of suspected mixed amyloidosis, immunohistochemical characterization of fibrils should be carried out by electron microscopy...
The treatment of fistulae and ureteral stenosis after kidney transplantationV Li Marzi
Department of Urology II, Florence University, Florence, Italy
Transplant Proc 37:2516-7. 2005..An early endoscopic approach permits resolution in 70% of cases. The aim of this retrospective study was to determine incidence and treatment of these complications...
Disseminated Scedosporium apiospermum infection in renal transplant recipient: long-term successful treatment with voriconazole: a case reportP G Rogasi
Malattie Infettive, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Transplant Proc 39:2033-5. 2007..The infection was successfully treated with voriconazole, but due to the severe iatrogenic immune suppression, a strong reduction in immunosuppressant drugs was needed...
Cardiovascular risk factors in severe chronic renal failure: the role of dietary treatmentF Bergesio
Department of Nephrology, Dialysis and Transplantation, Azienda Ospedale Careggi, Florence, Italy
Clin Nephrol 64:103-12. 2005..Aim of this study was to investigate the influence of vegan diet supplemented with essential amino acids (EAA) and ketoanalogues (VSD) on both traditional and non-traditional cardiovascular risk factors (CVRF)...
Preemptive cadaveric renal transplantation: fairness and utility in the case of high donation rate-pilot experience of Tuscany regionM Salvadori
Renal Unit, Careggi University Hospital, Florence, Italy
Transplant Proc 41:1084-6. 2009..43 in the preemptive group and 1.68 +/- 0.92 in the dialysis group (P = NS). No differences were observed concerning rejection rate. The preemptive listing rate for cadaveric renal transplantation was more than 35% for Tuscany patients...
Renal transplant recipients are at high risk for both symptomatic and asymptomatic deep vein thrombosisD Poli
Department of Critical Care Medicine, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
J Thromb Haemost 4:988-92. 2006..Venous thromboembolism (VTE) is one of the thrombotic complications that can occur in patients receiving renal transplantation (RT). The prevalence of VTE in RT patients is, however, undefined...
Posttransplant proteinuria associated with everolimusE Bertoni
Renal Unit, Careggi University Hospital, Firenze, Italy
Transplant Proc 41:1216-7. 2009..The specific urinary markers may reflect renal alterations related to the transplant or specific alterations associated with the drug...
[Factors predicting outcome in renal transplantation]E Bertoni
Nefrologia dei Trapianti e Dialisi, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy
G Ital Nefrol 22:551-61. 2005..Recent findings indicate that certain cytokines or special lymphocyte subsets (alloreactive T memory cells) in the recipient could be powerful markers in the next future...
In renal transplantation blood cyclosporine levels soon after surgery act as a major determinant of rejection: insights from the MY.S.S. trialNorberto Perico
Department of Medicine and Transplantation, Azienda Ospedaliera, Ospedali Riuniti di Bergamo-Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Kidney Int 65:1084-90. 2004....
High pretransplant serum levels of CXCL10/IP-10 are related to increased risk of renal allograft failureMario Rotondi
Department of Clinical Pathophysiology, University of Florence, Italy
Am J Transplant 4:1466-74. 2004..787). Thus, measurement of pretransplant serum CXCL10 levels might represent a clinically useful parameter to identify subjects who are at high risk of severe rejection and graft failure...
Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trialGiuseppe Remuzzi
Clinical Research Centre for Rare Diseases, Aldo e Cele Dacc, Mario Negri Institute for Pharmacological Research, Villa Camozzi, Ranica, Bergamo, Italy
Lancet 364:503-12. 2004..Standard immunosuppression regimens for transplantation should perhaps include azathioprine rather than mycophenolate mofetil, at least for kidney grafts...
Performance of different prediction equations for estimating renal function in kidney transplantationFlavio Gaspari
Department of Medicine and Transplantation, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Am J Transplant 4:1826-35. 2004..In clinical trials of kidney transplantation, graft function should be preferably monitored using a reference method of GFR measurement, such as iohexol plasma clearance...
High CXCL10 expression in rejected kidneys and predictive role of pretransplant serum CXCL10 for acute rejection and chronic allograft nephropathyElena Lazzeri
Center for Research, Transfer and High Education MCINDENT, Florence, Italy
Transplantation 79:1215-20. 2005..Several experimental models have shown that CXCL10 is required for initiation and development of graft failure caused by both acute and chronic rejection...
Follow-up after renal transplantation with organs from donors after cardiac deathJeremy Chapman
Renal Unit, Westmead Hospital, Westmead, NSW, Australia
Transpl Int 19:715-9. 2006....
Efficacy and safety of enteric-coated mycophenolate sodium in renal transplant patients with diabetes mellitus: post hoc analyses from three clinical trialsFrank Pietruck
Department of Nephrology, University Hospital Essen, Essen, Germany
Clin Transplant 21:117-25. 2007..Moreover, diabetic patients can apparently be safely converted from MMF to EC-MPS. More data from prospective studies are needed to fully judge the efficacy and safety profile of EC-MPS in the diabetic transplant population...
Mycophenolate mofetil versus azathioprine for prevention of chronic allograft dysfunction in renal transplantation: the MYSS follow-up randomized, controlled clinical trialGiuseppe Remuzzi
Department of Renal Medicine, Mario Negri Institute for Pharmacological Research, Negri Bergamo Laboratories, Via Gavazzeni 11, 24125 Bergamo, Italy
J Am Soc Nephrol 18:1973-85. 2007..In view of the cost, standard immunosuppression regimens for kidney transplantation should perhaps include azathioprine rather than MMF...
Randomized controlled trial of FTY720 versus MMF in de novo renal transplantationHelio Tedesco-Silva
Setor de Transplante Renal, Hospital do Rim Hipertensão UNIFESP, Rua Borges, Lagoa, 960 11o andar, Sao Paulo, SP, Brazil
Transplantation 82:1689-97. 2006..Phase II trials of FTY720, a novel immunomodulator, have shown promise in preventing rejection with both standard and reduced cyclosporine exposure. This study was designed to confirm those findings...
A randomized exploratory trial of steroid avoidance in renal transplant patients treated with everolimus and low-dose cyclosporineGiuseppe Montagnino
Nephrology Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, 20122, Italy
Nephrol Dial Transplant 23:707-14. 2008..In this randomized trial, we explored whether the use of everolimus associated with low-dose cyclosporine could allow an early avoidance of steroids in de novo renal transplant recipients...
High rate of recurrence in renal transplant recipients after a first episode of venous thromboembolismDaniela Poli
Department of Critical Care Medicine, Centro di Riferimento Regionale per la Trombosi, Azienda Ospedaliera Universitaria Careggi, Firenze
Transplantation 80:789-93. 2005..Our study was undertaken to evaluate the risk of VTE recurrence in patients developing a first episode of VTE after RT...
Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipientsRossella Marcucci
Surgical and Medical Critical Care, Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Italy
Transplantation 75:1551-5. 2003..The mean percentage of cIMT increase was + 23.3+/-21.1%. CONCLUSIONS: Our results demonstrate a beneficial effect of the treatment of hyperhomocysteinemia by vitamin supplementation on cIMT in a group of RTRs...
Renal involvement in systemic amyloidosis--an Italian retrospective study on epidemiological and clinical data at diagnosisFranco Bergesio
Renal Unit Azienda Ospedaliero Universitaria Careggi, Villa Monna Tessa, Viale Pieraccini 18, 50139 Florence, Italy
Nephrol Dial Transplant 22:1608-18. 2007..Few data are available on epidemiology and clinical picture of renal involvement in different forms of systemic amyloidosis...
Changes in viremia and circulating interferon-alpha during hemodialysis in hepatitis C virus-positive patients: only coincidental phenomena?Salvatore Badalamenti
Division of Nephrology, Istituto Clinico Humanitas, Milan, Italy
Am J Kidney Dis 42:143-50. 2003..The aim of the present study in HCV-positive (HCV+) HD patients is to determine whether HD induces the production of interferon-alpha (IFN-alpha) and if such production can contribute to viremia reduction...
IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxidePaola Romagnani
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
J Am Soc Nephrol 13:53-64. 2002..These data also indicate that the production of IP-10 and Mig by human mesangial cells can be downregulated by NO donors through cGMP-independent inhibition of NF-kappaB activation...
A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathyClaudio Ponticelli
Istituto Scientifico Auxologico Italiano, Milan, Italy
Am J Kidney Dis 47:233-40. 2006..We conducted a pilot trial to compare the effectiveness and safety of 2 different treatments in patients with membranous nephropathy and nephrotic syndrome...
Nephrotic syndrome and renal failure after allogeneic stem cell transplantation: novel molecular diagnostic tools for a challenging differential diagnosisPaola Romagnani
Department of Clinical Pathophysiology, Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Italy
Am J Kidney Dis 46:550-6. 2005....
