Z Ricci

..This result might be related to its ability to restore leukocyte responsiveness to lipopolysaccharide. These findings suggest a potential role for blood purification in the treatment of septic shock...

..CRRT and net UF delivery appeared to be accurate, safe, and effective in this small cohort of high-risk pediatric patients...

..New biomarkers for AKI have shown promise for early diagnosis and prediction of the prognosis of AKI. As more data become available, they could, in the future, be incorporated into improved definitions or criteria for AKI...

..This review focusses on the issue of fluid replacement quality and quantity and their association with renal dysfunction...

..To evaluate the safety and efficacy of levosimendan in neonates with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass (CPB)...

..In the past 3 years substantial progress has been made in the field of renal replacement therapy (RRT) for critically ill patients...

..To evaluate diagnostic and prognostic significance of neutrophil gelatinase-associated lipocalin during extracorporeal membrane oxygenation in children with congenital heart disease...

..Finally, new preventive strategies might be experimented in order to protect critically ill patients from septic AKI...

..This is especially true for the mode and dose of RRT. This review describes the epidemiology of dialysis prescription and delivery around the world based on recent observational studies and international surveys...

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..To report a case of a newborn patient with renal failure due to polycystic kidneys requiring renal replacement therapy, and total anomalous pulmonary venous return requiring major cardiosurgical intervention...

..And fourth, alternative indications to extracorporeal treatment of ARF and systemic inflammatory response syndrome have been explored by three original clinical studies...

..It also suggests that even mild degrees of kidney dysfunction may have a negative impact on outcome. Further refinement of RIFLE nomenclature and classification is ongoing...

..Finally, specific technical features of renal replacement therapies were examined in 2007, specifically regarding anticoagulation and vascular access...

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..However, acute lung injury with its attendant hypoxemia, hypercapnia and mechanical ventilation worsens renal hemodynamics and function...

..This review aims to describe the recent clinical, scientific and technical evolution of renal replacement therapy and the potential suggestive concept of multiple organ support therapy...

..The aim of the study was to evaluate the effects of high-dose fenoldopam, a selective dopamine-1 receptor, on renal function and organ perfusion during cardiopulmonary bypass (CPB) in infants with congenital heart disease (CHD)...

..Monitoring of fluid balance will be reviewed. Specific modalities of pediatric extracorporeal fluid removal will be presented...

..The best modality, for continuous renal replacement therapy (CRRT) is currently uncertain and it is poorly understood how transport of different solutes, whether convective or diffusive, changes over time...

..In the absence of an optimal dialysis dose, it can only be recommended that the prescription should exceed that calculated to be "adequate."..

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..Finally, in the extracorporeal treatment of ARF, the ability of two types of high cutoff haemofilters to influence blood levels of middle- and high-molecular-weight toxins showed promise...

..The study was conducted to validate in vivo the Adequacy Calculator, a Microsoft Excel-based program, designed to assess the prescription and delivery of renal replacement therapy in the critical care setting...

..In this lack of harmony, the epidemiology of ARF has recently displayed an outbreak of cases in the intensive care units and nephrologists and intensivists are now called to work together in the case of such a syndrome...

..This article will describe our first experience with this new device and touch upon the historic and technologic background leading to its development...

..These therapies could be able to reduce the peaks of the pro- and anti-inflammatory substances circulating during the syndrome, leading to a less severe degree of inflammation and immunodepression...

..In particular, we will focus on the importance of increased ultrafiltration volume and its impact on mortality in the general ICU population and in septic patients...

..The use of on-line blood volume monitors can be of further help in improving tolerance and the hemodynamic response...

..The potential for a home-based application of these techniques represents a further stimulating concept to be investigated...

..This is also crucial for renal recovery during acute renal failure...

..Fenoldopam was well tolerated and did not negatively affect hemodynamics and vasopressor support...

..The clinical significance of this finding is uncertain. A large multiple-center trial is now needed to confirm these findings...

..Although these approaches are still in the early stages of clinical testing, they are conceptually promising and might represent an important advance...

..The system could become an important complementary therapy for patients with congestive heart failure for whom classic methods of treatment have failed or simply are not available...

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..A short description of pediatric renal replacement therapies and their potential application to extracorporeal membrane oxygenation will also be described...

..Plasma DNA can also derive from bacteria. We have recently implemented a method to detect bacterial DNA and, in the present study, we validated this technique comparing it to standard blood culture in terms of diagnostic efficacy...

..The used radiological technique allows detailed flow distribution analysis and has the potential for testing future modifications to dialyzer design...

..05). During 80 ml/kg/h CVVH, utilizing polyacrylonitrile membranes, BNP is efficiently cleared from blood in a small cohort of pediatric post-cardiosurgical patients. In this situation, BNP absolute blood levels may be unpredictable...

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..Thus the patient may benefit from a lesser degree of immunodysregulation and he/she may restore a close-to-normal capacity of response to exogenous stimuli...

..It may be a beneficial adjuvant treatment for severe sepsis/septic shock in terms of patient survival, and it represents a compromise between continuous renal replacement therapy and HVHF...

..8%, P=0.02). Peritoneal dialysis in neonates allows optimal ultrafiltration rate and adequate small solute clearance, irrespective of hemodynamic status or vasopressor support...

..In addition, early initiation of renal replacement therapy to prevent fluid overload may result in improved infant outcomes...

..In paediatric CRRT, epidemiological investigations and prospective trials to investigate practical aspects of extracorporeal therapies are welcome and urgently needed...

..In the near future, however, only increased awareness of AKI incidence and early treatment or prevention of kidney injury progression will hopefully improve outcome of critically ill patients with renal failure...

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..Should such supplementation be routinely performed?..

..Furthermore, a brief speculation on the concept of adequacy of therapy is provided...

..This technique is fast, accurate, reproducible and noninvasive. In the setting of congenital heart surgery, TCD finds application in the evaluation of cerebral blood flow variations during cardiopulmonary bypass (CPB)...

..PHVHF appears to be a feasible modality that may provide the same or greater benefits as HVHFwhile reducing the workload and cost...

..It allows implementation into a user-friendly software tool and might be used to predict the convective component in high-flux dialysis and possibly to optimize it...