Research Topics
| A RicciSummaryCountry: Italy Publications
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Detail Information
Publications
Effects of shock waves on microcirculation, perfusion, and pain management in critical limb ischemiaG Belcaro
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti Pescara University, San Valentino Vascular Screening Center, San Valentino, Italy
Angiology 56:403-7. 2005..These results are very interesting, confirming previous observations, and opening new treatment options in CLI. The skin flow improvement did not relate to an increase in pressure...
Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled studyM R Cesarone
Department of Biomedical Sciences, G D Annunzio, Chieti Pescara University, Faculty of Motory Sciences, L Aquila University, Italy
Phytomedicine 17:835-9. 2010..05). No side-effects were observed; compliance and tolerability were very good. This study corroborates a significant clinical role for Pycnogenol in the management, treatment and control of CVI also in combination with compression...
Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspectsG Belcaro
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti pescara University and San Valentino Vascular Screening Project, San Valentino, PE, Italy
Phytother Res 22:518-23. 2008..After 3 months edema decreased in 79% of Pycnogenol patients (p < 0.05) vs 1% in controls. In conclusion, Pycnogenol offers an option for reduction of treatment costs and side effects by sparing antiinflammatory drugs...
Prevention of edema and flight microangiopathy with Venoruton (HR), (0-[beta-hydroxyethyl]-rutosides) in patients with varicose veinsM R Cesarone
Vascular Laboratory and San Valentino Vascular Screening Project, Department of Biomedical Sciences, G D'Annunzio University, Chieti-Pescara and Faculty of Motor Sciences, Italy
Angiology 56:289-93. 2005..The higher level of flux and VAR and the reduction in edema indicate a positive effect of HR on the microcirculation. This study confirms that HR prophylaxis is effective to control flight microangiopathy associated with edema...
Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled studyM R Cesarone
Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G 'Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L'Aquila University, Italy
Angiology 57:569-76. 2006..The treatment may be also useful to prevent ulcerations by controlling the level of venous microangiopathy...
HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry studyM R Cesarone
Irvine2 Vasc Lab and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
Angiology 56:1-8. 2005..The comparison with D+H indicates that HR is comparatively more effective both on microcirculatory parameters and on signs/symptoms of CVI...
Prevention of edema in long flights with PycnogenolM R Cesarone
Department of Biomedical Sciences, Irvine2 Vascular Lab, G D'Annunzio University and San Valentino Vascular Screening Project (Pe, Faculty of Motory Sciences, L'Aquila University, Italy
Clin Appl Thromb Hemost 11:289-94. 2005..05). These results indicate a positive effect of Pycnogenol on edema during long flights when considering subjective and objective data. No unwanted effects were observed...
Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled studyM R Cesarone
Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D'Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L'Aquila University, Italy
Clin Appl Thromb Hemost 12:205-12. 2006....
HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled studyM R Cesarone
Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G. D'Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, San Valentino, Italy
Angiology 56:165-72. 2005..Venous microangiopathy and edema were improved by the treatment with HR within a few days. The effects were visible with both dosages, in both severity groups...
Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiencyM R Cesarone
Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
Angiology 57:131-8. 2006..The comparison with D+H indicates that oxerutins is comparatively more effective on Ve-QOL and on signs/symptoms of CVI...
Venous ulcers: microcirculatory improvement and faster healing with local use of PycnogenolG Belcaro
Department of Biomedical Sciences, Chieti Pescara University, Italy
Angiology 56:699-705. 2005..According to this pilot study Pycnogenol appears to have an important role in local treatment of venous ulcers improving healing and signs/symptoms...
Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled studyM R Cesarone
Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D'Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L'Aquila University, Italy
Angiology 57:431-6. 2006..The study indicates the clinical role of Pycnogenol in the management, treatment, and control of this common clinical problem. The treatment may be also useful to prevent diabetic ulcerations by controlling the level of microangiopathy...
Treatment of ankle sprain in patients with vascular diseases of the lower limbsM R Cesarone
Irvine3 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Pescara, Italy
Minerva Cardioangiol 56:39-46. 2008..The observed clinical outcomes of the patients included in this small, pilot study indicated that locally applied ketoprofen 10% spray gel is effective in relieving the pain and other symptoms of ankle sprain in vascular patients...
Prevention of venous thrombosis in long-haul flights with Flite Tabs: the LONFLIT-FLITE randomized, controlled trialM R Cesarone
Department of Biomedical Sciences, Irvine2 Vascular Lab, G D'Annunzio University, San Valentino Vascular Screening Project (Pe, Pescara, Italy
Angiology 54:531-9. 2003..4%) in the treatment group (p < 0.05). Events were asymptomatic. In conclusion, Flite Tabs were effective in reducing thrombotic events and in controlling edema in high-risk subjects in long flights...
Flight microangiopathy on long-haul flights: prevention of edema and microcirculation alterations with VenorutonM R Cesarone
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University, Italy
Clin Appl Thromb Hemost 9:109-14. 2003..In conclusion, HR is useful for reducing the increased capillary filtration and in controlling edema in patients with chronic venous disease in long-haul flights. HR is effective to control flight microangiopathy associated with edema...
Four-week treatment with Essaven gel in diabetic microangiopathy--a placebo-controlled, randomized studyM T De Sanctis
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy
Angiology 52:S49-55. 2001..In conclusion local treatment for 4 weeks with standardized application of EG improves the microcirculation in subjects with DM. The changes are detectable even 1 week after the end of the treatment period...
Variations in plasma free radicals with topical aescin + essential phospholipids gel in venous hypertension: new clinical dataA Ricci
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy
Angiology 55:S11-4. 2004..The evaluation of PFR is an important new physiologic parameter that can be associated with other noninvasive tests to study the microcirculation and its evolution and improvement with systemic or topical medical treatment...
Treatment of superficial vein thrombosis: clinical evaluation of Essaven gel--a placebo-controlled, 8-week, randomized studyL Incandela
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy
Angiology 52:S69-72. 2001..In conclusion local treatment with EG in SVT improves signs/symptoms much faster than placebo. This study confirms earlier observation on the effective, local use of EG in SVT...
Clinical improvement in chronic venous insufficiency signs and symptoms with Venoruton® (HR): an 8-month, open-registry, cost-efficacy studyM R Cesarone
Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara Univeristy, Pescara, Italy
Panminerva Med 52:43-8. 2010..This study evaluated the clinical efficacy of Venoruton (O-(beta-hydroxyethyl)-rutosides) (HR) (Novartis Consumer Healthcare) in subjects with severe chronic venous insufficiency (CVI)...
Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenolG Belcaro
Department of Biomedical Sciences, Irvine2 Vascular Lab, G D Annunzio University and San Valentino Vascular Screening Project Pe, Faculty of Motory Sciences, L Aquila University, Italy
Clin Appl Thromb Hemost 10:373-7. 2004..025). No unwanted effects were observed. In conclusion, this study indicates that Pycnogenol treatment was effective in decreasing the number of thrombotic events (DVT and SVT) in moderate-to-high risk subjects, during long-haul flights...
Efficacy of topical treatment with aescin + essential phospholipids gel on capillary fragilityM R Cesarone
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G D Annunzio University, Italy
Angiology 55:S23-5. 2004..The tests were repeated in steps of two tests on different days. Between the two tests, with the VSC applied in different skin areas of the perimalleolar region, an interval of at least 30 minutes was observed...
Venous and diabetic ulcerations: management with topical multivalent silver oxide ointmentG Belcaro
Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
Panminerva Med 52:37-42. 2010..The goal of this pilot registry study is to evaluate the efficacy and safety of a uniquely designed ointment containing multivalent silver oxide (Ag4O4) in the healing of difficult diabetic or venous ulcerations...
A plaster combining diclofenac and heparin: microcirculatory evaluation in 2 models of high-perfusion microangiopathyG Belcaro
Department of Biomedical Sciences, Chieti Pescara University, Italy
Angiology 56:707-13. 2005..It should be interesting to investigate the product in comparable clinical conditions in which it may be useful to act pharmacologically both on inflammation and microcirculatory disturbances that delay the recovery of patients...
Topical heparin: new observationsM R Cesarone
Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, Chieti Pescara University, Faculty of Motory Sciences, L Aquila University, San Valentino, Italy
Angiology 58:16S-20S. 2007..Results from new studies and observations presented in this issue of Angiology could be a window for suggesting new significant clinical applications and therapeutic solutions...
[Severe intermittent claudication: PGE1 treatment. A 40-week registry, efficacy and costs]R Luzzi
Department of Biomedical Sciences, Chieti Pescara University, Italy
Minerva Cardioangiol 60:405-13. 2012..Treatment with PGE1 has been successfully used to manage IC patients. This registry has evaluated safety and costs of PGE1 in the management of IC...
Pycnogenol may alleviate adverse effects in oncologic treatmentG Belcaro
Vascular Labs and Physiology, Department of Biomedical Sciences, Gabriele d Annunzio University, Chieti Pescara, Chieti, Italy
Panminerva Med 50:227-34. 2008..The aim of this study was to explore in a pilot trial whether supplementation with French maritime pine bark extract Pycnogenol could alleviate side effects and improve patient's quality of life...
Two-week topical treatment with Essaven gel in patients with diabetic microangiopathy--a placebo-controlled, randomized studyM R Cesarone
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy
Angiology 52:S43-8. 2001..In conclusion, local treatment for 2 weeks with standardized application of EG acutely improves the microcirculation in subjects with DM and small ulceration...
Gore external valve support for superficial saphenous vein incompetence: a 10-year, follow-up registryG Belcaro
Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
Panminerva Med 53:35-41. 2011....
Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry studyG Belcaro
Department of Biomedical Sciences, Irvine3 Circulation Vascular Labs and San Valentino Vascular Screening Project, G D Annunzio University, Chieti, Pescara, Italy
Panminerva Med 52:269-75. 2010..Compliance was very good. In conclusion, the administration of immunomodulators is very cost effective and appears to be more effective than vaccination to prevent flu...
Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel on transcutaneous PO2 in venous insufficiencyM R Cesarone
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy
Angiology 55:S7-10. 2004..Considering transcutaneous skin PO(2), treatment with AEPL in areas of venous microangiopathy is beneficial in the prevention of ulceration and improves skin healing...
Lady Prelox® improves sexual function in post-menopausal womenA Bottari
Irvine3 Circulation Vascular Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
Panminerva Med 54:3-9. 2012..The aim of this pilot, single-blinded study was to evaluate the efficacy of a proprietary, dietary supplement Lady Prelox® for supporting and improving sexual function in generally healthy, post-menopausal women...
Prevention of venous thrombosis with elastic stockings during long-haul flights: the LONFLIT 5 JAP studyG Belcaro
Department of Biomedical Sciences, Irvine2 Vascular Lab, G D Annunzio University, San Valentino Vascular Screening Project, PE, Italy
Clin Appl Thromb Hemost 9:197-201. 2003..All events were asymptomatic. Considering these observations, Scholl Flight Socks are effective in reducing the incidence of DVT in high-risk subjects...
Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide. Evaluation of free radicals, laser Doppler flux and PO2. A prospective-randomized-controlled studyG Belcaro
Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
Angiology 54:325-30. 2003..05). In conclusion, in venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals improving healing...
Endovascular sclerotherapy, surgery, and surgery plus sclerotherapy in superficial venous incompetence: a randomized, 10-year follow-up trial--final resultsG Belcaro
PAP PEA Institute, San Valentino, Pescara, Italy
Angiology 51:529-34. 2000..2 cm after ES). The cost of ES was 68% of surgery while the cost of surgery and sclerotherapy was 122% of surgery only. Endovascular sclerotherapy is an effective, cheaper treatment option, but surgery after 10 years is superior...
Thyroid cysts treatment with the sclerosing agent Atossiclerol. Long-term (5 to 15 years) follow-upG Belcaro
Irvine3 Circulation Vascular Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
Panminerva Med 54:73-6. 2012..The aim of this study was to evaluate the long-term efficacy of the sclerosing agent Atossisclerol in the treatment of benign, ecolucent, thyroid cysts...
HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trialG Belcaro
Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
J Cardiovasc Pharmacol Ther 7:139-45. 2002..CONCLUSION: Venous microangiopathy was improved by the treatment with Venoruton. The comparison with Daflon indicates that HR is comparatively more effective both on microcirculatory parameters and on signs and symptoms...
Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetryM R Cesarone
Irvine Vascular Laboratory, St Mary's Hospital and Imperial College, London, UK
Angiology 52:S45-8. 2001..In conclusion, TTFCA improves microcirculation and leg volume in venous hypertension. The effects of TTFCA are observed even in a limited sample of patients...
MRI activity and neutralising antibody as predictors of response to interferon beta treatment in multiple sclerosisL Durelli
Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Ospedale San Luigi Gonzaga, Regione Gonzole, 10, I 10043 Orbassano, Torino, Italy
J Neurol Neurosurg Psychiatry 79:646-51. 2008..To prospectively validate MRI activity and neutralising anti-interferon antibody (NAb) during the first 6 months of interferon beta treatment as response indicators in multiple sclerosis (MS)...
One-day surgery for acquired forefoot deformity: sciatic nerve blockade with mepivacaine vs mepivacaine+ropivacaine: a prospective, randomized studyS Bugamelli
Department of Anesthesiology, and Intensive Care IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
Minerva Anestesiol 73:57-64. 2007....
Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenolG Belcaro
Irvine2 Vasc Lab, Department of Biomedical Sciences, Chieti-pescara University and San Valentino Vascular Screening Project, , Germany
Clin Appl Thromb Hemost 12:318-23. 2006..Combined local and systemic application of Pycnogenol may offer a new treatment of diabetic ulcers. Local treatment also speeds ulcer healing...
Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathyG Vinciguerra
Irvine 2 Vascular Laboratory and Physiology Department of Biomedical Sciences, G D Annunzio University, Chieti, Italy
Angiology 57:331-9. 2006....
Combination therapy in COPD: different response of COPD stages and predictivity of functional parametersC Terzano
Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, Fondazione E. Lorillard Spencer Cenci, La Sapienza University--Rome, Italy
Eur Rev Med Pharmacol Sci 9:209-15. 2005..Starting FEV1/FVC and MEF50 were significant predictors in mild and moderate stages, and starting DLCO/VA% resulted a significant predictor in moderate and severe stages...
Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis (INCOMIN Trial) II: analysis of MRI responses to treatment and correlation with NabP Barbero
Clinica Neurologica I, Dipartimento di Neuroscienze, Universita degli Studi di Torino, Italy
Mult Scler 12:72-6. 2006....
