Fabrizio Facchinetti

Summary

Affiliation: Research and Innovation (R and I) Company
Country: Italy

Publications

  1. ncbi H(2)O(2) induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP
    F Facchinetti
    Research and Innovation Company, Padova, Italy
    J Neurosci Res 69:178-88. 2002
  2. ncbi Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide
    Fabrizio Facchinetti
    Research and Innovation R and I Company, Padova, Italy
    Glia 41:161-8. 2003
  3. ncbi Dopamine inhibits responses of astroglia-enriched cultures to lipopolysaccharide via a beta-adrenoreceptor-mediated mechanism
    Fabrizio Facchinetti
    Neurobiology Unit, Research and Innovation Company, via Svizzera 16, 35127 Padova, Italy
    J Neuroimmunol 150:29-36. 2004
  4. ncbi Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage
    Fabrizio Facchinetti
    Research and Innovation R and I Company, Padova, Italy
    Neurobiol Aging 27:218-27. 2006
  5. ncbi Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells
    Elda Del Giudice
    Research and Innovation R and I Company, Padova, Italy
    J Leukoc Biol 81:1512-22. 2007
  6. ncbi Octopamine, unlike other trace amines, inhibits responses of astroglia-enriched cultures to lipopolysaccharide via a β-adrenoreceptor-mediated mechanism
    Giovanni D'Andrea
    Research and Innovation S p A, via Svizzera 16, 35127 Padova, Italy
    Neurosci Lett 517:36-40. 2012
  7. ncbi Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma
    Elda Del Giudice
    Research and Innovation Company, Padova, Italy
    Neurosci Lett 418:9-12. 2007
  8. ncbi Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion
    Ilaria Peretto
    Research and Development, Chiesi Farmaceutici S.p.A, Via Palermo 26/A, 43100 Parma, Italy
    J Med Chem 48:5705-20. 2005
  9. ncbi 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity
    Bruno P Imbimbo
    Research and Development, Chiesi Farmaceutici, Via Palermo 26 A, 43100 Parma, Italy
    J Pharmacol Exp Ther 323:822-30. 2007
  10. ncbi In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents
    Bruno P Imbimbo
    Research and Development Department, Chiesi Farmaceutici, Via Palermo 26 A, 43100 Parma, Italy
    Pharmacol Res 55:318-28. 2007

Collaborators

  • Antonello D'Arrigo
  • A Leon
  • B P Imbimbo
  • P Geppetti
  • Bart De Strooper
  • Elda Del Giudice
  • Giovanni D'Andrea
  • Ilaria Peretto
  • Daniele Bernardini
  • Davide Colavito
  • Tullio Minelli
  • Marzia Passarotto
  • Valentina Nofrate
  • Leontino Battistin
  • Maurizio Dalle Carbonare
  • Luciano Rinaldi
  • Pasquale Boccaccio
  • Giuliano Moschini
  • Adriano Guiotto
  • Mauro Dam
  • Stefano Radaelli
  • Benedetta Riccardi
  • Paola Misiano
  • Chiara Bigogno
  • Gino Villetti
  • Giulio Dondio
  • Luca F Raveglia
  • Valentina Cenacchi
  • Paola Puccini
  • Nadia Moretto
  • Silvia Marchetti
  • Paola Caruso
  • Michele Zandi
  • Ivano Rondelli
  • Silvia Catinella
  • Carlo Parini
  • Andrea Rizzi
  • Pier Tonino Bolzoni
  • Marcello Biscaioli
  • Laura Fontanella

Detail Information

Publications11

  1. ncbi H(2)O(2) induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP
    F Facchinetti
    Research and Innovation Company, Padova, Italy
    J Neurosci Res 69:178-88. 2002
    ..Moreover, we describe here for the first time the existence of cAMP-dependent mechanism(s) modulating Fas and FasL expression...
  2. ncbi Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide
    Fabrizio Facchinetti
    Research and Innovation R and I Company, Padova, Italy
    Glia 41:161-8. 2003
    ..By showing that such effect does not appear to be mediated by either CB receptor type 1 or 2, we provide evidence suggestive of the existence of yet unidentified cannabinoid receptor(s) in brain microglia...
  3. ncbi Dopamine inhibits responses of astroglia-enriched cultures to lipopolysaccharide via a beta-adrenoreceptor-mediated mechanism
    Fabrizio Facchinetti
    Neurobiology Unit, Research and Innovation Company, via Svizzera 16, 35127 Padova, Italy
    J Neuroimmunol 150:29-36. 2004
    ..These data, consistent with a role of DA as local modulator of glial inflammatory responses, uncover the existence of an interaction between DA and heterologous beta-adrenergic receptors in astroglial cells...
  4. ncbi Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage
    Fabrizio Facchinetti
    Research and Innovation R and I Company, Padova, Italy
    Neurobiol Aging 27:218-27. 2006
    ....
  5. ncbi Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells
    Elda Del Giudice
    Research and Innovation R and I Company, Padova, Italy
    J Leukoc Biol 81:1512-22. 2007
    ..e., receptors and/or ion channels associated with Ca(2+) influx of natural cannabinoids such as CBD and THC, the identification of which has the potential to provide for novel strategies and agents of therapeutic interest...
  6. ncbi Octopamine, unlike other trace amines, inhibits responses of astroglia-enriched cultures to lipopolysaccharide via a β-adrenoreceptor-mediated mechanism
    Giovanni D'Andrea
    Research and Innovation S p A, via Svizzera 16, 35127 Padova, Italy
    Neurosci Lett 517:36-40. 2012
    ..These results may have an impact in understanding the mechanisms underlying migraine pathophysiology...
  7. ncbi Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma
    Elda Del Giudice
    Research and Innovation Company, Padova, Italy
    Neurosci Lett 418:9-12. 2007
    ..These findings show for the first time that exposure to LF-EMF stimulates Abeta secretion in vitro, thus alluding to a potential link between LF-EMF exposure and APP processing in the brain...
  8. ncbi Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion
    Ilaria Peretto
    Research and Development, Chiesi Farmaceutici S.p.A, Via Palermo 26/A, 43100 Parma, Italy
    J Med Chem 48:5705-20. 2005
    ..Studies in a transgenic mice model of AD showed that selected compounds significantly decreased plasma Abeta42 concentrations. These new flurbiprofen analogues represent potential drug candidates to be developed for the treatment of AD...
  9. ncbi 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity
    Bruno P Imbimbo
    Research and Development, Chiesi Farmaceutici, Via Palermo 26 A, 43100 Parma, Italy
    J Pharmacol Exp Ther 323:822-30. 2007
    ..CHF5074 is therefore a promising therapeutic agent for Alzheimer's disease...
  10. ncbi In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents
    Bruno P Imbimbo
    Research and Development Department, Chiesi Farmaceutici, Via Palermo 26 A, 43100 Parma, Italy
    Pharmacol Res 55:318-28. 2007
    ..105) with CHF5022 concentration in the brain. CHF5022 and CHF5074 thus appear to have a promising in vitro and in vivo profile. This warrants further evaluation of their long-term effects on Abeta brain pathology...
  11. ncbi Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages
    Fabrizio Facchinetti
    Department of Pharmacology, Chiesi Pharmaceuticals SpA, Parma, Italy
    Am J Respir Cell Mol Biol 37:617-23. 2007
    ..Our data demonstrate that alpha,beta-unsaturated aldehydes are major mediators of cigarette smoke-induced macrophage activation, and suggest that they might contribute to pulmonary inflammation associated with cigarette smoke...