L Gianaroli

Summary

Affiliation: Reproductive Medicine Unit
Country: Italy

Publications

  1. ncbi request reprint Oocyte euploidy, pronuclear zygote morphology and embryo chromosomal complement
    L Gianaroli
    S I S Me R, Reproductive Medicine Unit, Bologna, Italy
    Hum Reprod 22:241-9. 2007
  2. ncbi request reprint Frequency of aneuploidy in sperm from patients with extremely severe male factor infertility
    Luca Gianaroli
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Dept OB GYN, S Martino Hospital, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Hum Reprod 20:2140-52. 2005
  3. ncbi request reprint Sperm head's birefringence: a new criterion for sperm selection
    Luca Gianaroli
    Società Italiana Studi di Medicina della Reproduzione S I S M E R, Bologna, Italy
    Fertil Steril 90:104-12. 2008
  4. doi request reprint Objective way to support embryo transfer: a probabilistic decision
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, Bologna 40138, Italy
    Hum Reprod 28:1210-20. 2013
  5. doi request reprint Best practices of ASRM and ESHRE: a journey through reproductive medicine
    L Gianaroli
    Reproductive Medicine Unit, SIS MeR, Bologna, Italy
    Hum Reprod 27:3365-79. 2012
  6. doi request reprint Best practices of ASRM and ESHRE: a journey through reproductive medicine
    Luca Gianaroli
    Reproductive Medicine Unit, S I S Me R, Bologna, Italy
    Fertil Steril 98:1380-94. 2012
  7. doi request reprint DNA integrity is maintained after freeze-drying of human spermatozoa
    Luca Gianaroli
    Società Italiana Studi Medicina della Riproduzione S I S Me R, Reproductive Medicine Unit, Bologna, Italy
    Fertil Steril 97:1067-1073.e1. 2012
  8. doi request reprint Birefringence characteristics in sperm heads allow for the selection of reacted spermatozoa for intracytoplasmic sperm injection
    Luca Gianaroli
    Reproductive Medicine Unit, Italian Society for the Study of Reproductive Medicine, Via Mazzini 12, 40128 Bologna, Italy
    Fertil Steril 93:807-13. 2010
  9. pmc Predicting aneuploidy in human oocytes: key factors which affect the meiotic process
    L Gianaroli
    S I S Me R, Reproductive Medicine Unit, Via Mazzini, 12, 40138 Bologna, Italy
    Hum Reprod 25:2374-86. 2010
  10. ncbi request reprint The in vivo and in vitro efficiency and efficacy of PGD for aneuploidy
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138, Bologna, Italy
    Mol Cell Endocrinol 183:S13-8. 2001

Detail Information

Publications52

  1. ncbi request reprint Oocyte euploidy, pronuclear zygote morphology and embryo chromosomal complement
    L Gianaroli
    S I S Me R, Reproductive Medicine Unit, Bologna, Italy
    Hum Reprod 22:241-9. 2007
    ....
  2. ncbi request reprint Frequency of aneuploidy in sperm from patients with extremely severe male factor infertility
    Luca Gianaroli
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Dept OB GYN, S Martino Hospital, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Hum Reprod 20:2140-52. 2005
    ..A protocol for the chromosomal analysis of sperm samples with a severely reduced number of sperm cells was designed...
  3. ncbi request reprint Sperm head's birefringence: a new criterion for sperm selection
    Luca Gianaroli
    Società Italiana Studi di Medicina della Reproduzione S I S M E R, Bologna, Italy
    Fertil Steril 90:104-12. 2008
    ..To investigate the characteristics of birefringence in human sperm heads and apply polarization microscopy for sperm selection at intracytoplasmic sperm injection (ICSI)...
  4. doi request reprint Objective way to support embryo transfer: a probabilistic decision
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, Bologna 40138, Italy
    Hum Reprod 28:1210-20. 2013
    ..Is it feasible to identify factors that significantly affect the clinical outcome of IVF-ICSI cycles and use them to reliably design a predictor of implantation?..
  5. doi request reprint Best practices of ASRM and ESHRE: a journey through reproductive medicine
    L Gianaroli
    Reproductive Medicine Unit, SIS MeR, Bologna, Italy
    Hum Reprod 27:3365-79. 2012
    ..These societies have never before had a joint scientific meeting...
  6. doi request reprint Best practices of ASRM and ESHRE: a journey through reproductive medicine
    Luca Gianaroli
    Reproductive Medicine Unit, S I S Me R, Bologna, Italy
    Fertil Steril 98:1380-94. 2012
    ..These societies have never before had a joint scientific meeting...
  7. doi request reprint DNA integrity is maintained after freeze-drying of human spermatozoa
    Luca Gianaroli
    Società Italiana Studi Medicina della Riproduzione S I S Me R, Reproductive Medicine Unit, Bologna, Italy
    Fertil Steril 97:1067-1073.e1. 2012
    ..To evaluate the effects on human spermatozoa of freeze-drying, also known as lyophilization, and of cryopreservation in liquid nitrogen...
  8. doi request reprint Birefringence characteristics in sperm heads allow for the selection of reacted spermatozoa for intracytoplasmic sperm injection
    Luca Gianaroli
    Reproductive Medicine Unit, Italian Society for the Study of Reproductive Medicine, Via Mazzini 12, 40128 Bologna, Italy
    Fertil Steril 93:807-13. 2010
    ..To verify clinical outcome after injection of spermatozoa that have undergone the acrosome reaction (reacted spermatozoa) vs. those still having an intact acrosome (nonreacted spermatozoa)...
  9. pmc Predicting aneuploidy in human oocytes: key factors which affect the meiotic process
    L Gianaroli
    S I S Me R, Reproductive Medicine Unit, Via Mazzini, 12, 40138 Bologna, Italy
    Hum Reprod 25:2374-86. 2010
    ..To estimate the incidence of aneuploidy in relation to patients' characteristics, the type of hormonal stimulation and their response to induction of multiple follicular growth, 4163 first polar bodies (PB1s) were analyzed...
  10. ncbi request reprint The in vivo and in vitro efficiency and efficacy of PGD for aneuploidy
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138, Bologna, Italy
    Mol Cell Endocrinol 183:S13-8. 2001
    ..The transfer of PGD selected embryos in women of advanced reproductive age reduces by half the risk of having a trisomic pregnancy...
  11. ncbi request reprint Gonadal activity and chromosomal constitution of in vitro generated embryos
    L Gianaroli
    S I S Me R, Reproductive Medicine Unit, Via Mazzini 12, 40138, Bologna, Italy
    Mol Cell Endocrinol 161:111-6. 2000
    ..8%, P<0. 001). These findings indicate that poor responder patients are physiologically exposed not only to reduced chances of implantation, but also to an increased risk of spontaneous abortion and trisomic pregnancies...
  12. ncbi request reprint Birth of a healthy infant after conception with round spermatids isolated from cryopreserved testicular tissue
    L Gianaroli
    Reproductive Medicine Unit, S I S Me R, Bologna, Italy
    Fertil Steril 72:539-41. 1999
    ..To report a case of nonobstructive azoospermia in which round spermatids recovered from thawed testicular tissue were used for injection...
  13. ncbi request reprint Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed
    L Gianaroli
    Reproductive Medicine Unit, S I S Me R, Bologna, Italy
    Fertil Steril 72:837-44. 1999
    ..To verify whether advantages can derive from the implementation of preimplantation genetic diagnosis for aneuploidy in patients with a poor prognosis of full-term pregnancy, compared with conventional treatment procedures...
  14. ncbi request reprint Transvaginal ovarian drilling: a new surgical treatment for improving the clinical outcome of assisted reproductive technologies in patients with polycystic ovary syndrome
    A P Ferraretti
    Reproductive Medicine Unit, Società Italiana per gli Studi sulla Medicina della Riproduzione srl, Bologna, Italy
    Fertil Steril 76:812-6. 2001
    ..To evaluate the efficacy of transvaginal ovarian drilling (TVOD) in patients with polycystic ovary syndrome (PCOS) who were undergoing IVF treatment...
  15. ncbi request reprint Possible interchromosomal effect in embryos generated by gametes from translocation carriers
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 17:3201-7. 2002
    ..The aim of this study was to verify whether conventional aneuploidy screening could be advantageously combined with preimplantation genetic diagnosis (PGD) for translocations...
  16. ncbi request reprint Double locus analysis of chromosome 21 for preimplantation genetic diagnosis of aneuploidy
    M C Magli
    S.I.S.ME.R, Bologna, Italy
    Prenat Diagn 21:1080-5. 2001
    ..6% without missing any trisomy 21. In addition, the present study suggests that if two or more loci from the same chromosome could be simultaneously analyzed in single cells, errors caused by false monosomies could be reduced...
  17. ncbi request reprint Paternal contribution to aneuploidy in preimplantation embryos
    M C Magli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, Bologna, Italy
    Reprod Biomed Online 18:536-42. 2009
    ..This might occur especially in NOA patients in which the high incidence of chromosomal abnormalities is mainly due to mosaicism and gonosomal aneuploidy...
  18. ncbi request reprint Chromosomal abnormalities in embryos
    M C Magli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138, Bologna, Italy
    Mol Cell Endocrinol 183:S29-34. 2001
    ..These findings suggest that morphological criteria alone are not sufficient in poor prognosis patients to guarantee the best embryo selection...
  19. ncbi request reprint Biological factors affecting subzonal sperm microinjection results
    L Gianaroli
    Reproductive Medicine Center, S I S Me R, Bologna, Italy
    Reprod Fertil Dev 6:63-6; discussion 66-7. 1994
    ..This study followed the fate of injected oocytes and early embryo development to investigate biological factors that influence the results of subzonal injection...
  20. ncbi request reprint Clinical value of preimplantation genetic diagnosis
    L Gianaroli
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Placenta 24:S77-83. 2003
    ..In view of these findings, PGD has become an integral part of assisted reproductive techniques for the prevention of affected pregnancies and improvement of IVF efficiency...
  21. ncbi request reprint Medical therapy of oligoasthenospermia associated with left varicocele
    G Cavallini
    Società Italiana di Studi Medicina della Riproduzione, Reproductive Medicine Unit, Bologna, Italy
    BJU Int 91:513-8. 2003
    ..To ascertain whether a nonsteroidal anti-inflammatory drug (cinnoxicam) or surgical varicocelectomy are suitable therapies for oligoasthenospermia associated with varicocele...
  22. ncbi request reprint Prognostic role of preimplantation genetic diagnosis for aneuploidy in assisted reproductive technology outcome
    A P Ferraretti
    SISMER, Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 19:694-9. 2004
    ..The aim of this study was to demonstrate that PGD for aneuploidy has an important role in the prognosis of subsequent treatments...
  23. ncbi request reprint Role of aneuploidy on embryo implantation
    V I Farfalli
    Società Italiana Studi di Medicina della Riproduzione SISMER, Bologna, Italy
    Gynecol Obstet Invest 64:161-5. 2007
    ..Substantial evidence has been accumulated on the positive impact of the technique, reporting increased implantation rates and a concomitant decrease of spontaneous abortions and trisomic pregnancies...
  24. doi request reprint ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria
    A P Ferraretti
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 26:1616-24. 2011
    ..Finally, by reducing bias caused by spurious POR definitions, it will be possible to compare results and to draw reliable conclusions...
  25. ncbi request reprint Spermatogenesis and spectral echo-colour Doppler traces from the main testicular artery
    G Biagiotti
    Reproductive Medicine Unit, Società Italiana Studi di Medicina della Riproduzione SISMER, Bologna, Italy
    BJU Int 90:903-8. 2002
    ....
  26. ncbi request reprint The role of preimplantation diagnosis for aneuploidies
    Luca Gianaroli
    S I S M E R, Reproductive Medicine Unit, Bologna, Italy
    Reprod Biomed Online 4:31-6. 2002
    ....
  27. ncbi request reprint Cryopreservation of biopsied embryos at the blastocyst stage
    M C Magli
    S I S Me R, Reproductive Medicine Unit, Bologna, Italy
    Hum Reprod 21:2656-60. 2006
    ..In this study, embryos diagnosed as normal after PGD were grown to the blastocyst stage, frozen and thawed for successive frozen embryo transfer...
  28. ncbi request reprint First meiosis errors in immature oocytes generated by stimulated cycles
    M Cristina Magli
    Reproductive Medicine Unit, Italian Society for the Study of Reproductive Medicine, Bologna, Italy
    Fertil Steril 86:629-35. 2006
    ..To investigate chromosomal errors detected by first polar body (PB) biopsy in relation to the nuclear maturity of the oocytes...
  29. ncbi request reprint Infertility therapy-associated multiple pregnancies (births): an ongoing epidemic
    Eli Y Adashi
    University of Utah Health Sciences Center, Department of Obstetrics and Gynecology, Salt Lake City, Utah, USA
    Reprod Biomed Online 7:515-42. 2003
  30. ncbi request reprint Embryo morphology and development are dependent on the chromosomal complement
    M Cristina Magli
    Reproductive Medicine Unit, Società Italiana di Studi di Medicina della Riproduzione, Bologna, Italy
    Fertil Steril 87:534-41. 2007
    ..To analyze embryo morphology in relation to the corresponding chromosomal status, in order to evaluate the effects of aneuploidy over fragmentation, delayed cleavage, and arrested cleavage...
  31. ncbi request reprint Chromosome topology in normal and aneuploid blastomeres from human embryos
    Jan Diblík
    Center of Reproductive Genetics, Institute of Biology and Medical Genetics, Charles University, 2nd School of Medicine, University Hospital Motol, Prague, Czech Republic
    Prenat Diagn 27:1091-9. 2007
    ....
  32. ncbi request reprint Impact of parental gonosomal mosaicism detected in peripheral blood on preimplantation embryos
    M Cristina Magli
    SISMeR Reproductive Medicine Unit, Via Mazzini 12, Bologna, 40138 Italy
    Reprod Biomed Online 5:306-12. 2002
    ..There is an indication that this tendency is higher in female than male carriers...
  33. ncbi request reprint Pronuclear morphology and chromosomal abnormalities as scoring criteria for embryo selection
    Luca Gianaroli
    Società Italiana Studi Medicina della Riproduzione, Reproductive Medicine Unit, Bologna, Italy
    Fertil Steril 80:341-9. 2003
    ..To verify whether a correlation exists between pronuclear zygote morphology and the chromosomal condition of preimplantation embryos...
  34. ncbi request reprint Semen donor recruitment in an oocyte donation programme
    Anna Pia Ferraretti
    S I S Me R Reproductive Medicine Unit, Bologna, Italy
    Hum Reprod 21:2482-5. 2006
    ..The data indicate that the system would also work to encourage IVF patients to share their oocytes...
  35. ncbi request reprint Substandard application of preimplantation genetic screening may interfere with its clinical success
    Santiago Munne
    Reprogenetics, Livingston, New Jersey 07039, USA
    Fertil Steril 88:781-4. 2007
    ..At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial...
  36. ncbi request reprint Increased rate of aneuploid embryos in young women with previous aneuploid conceptions
    Santiago Munne
    Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, New Jersey, USA
    Prenat Diagn 24:638-43. 2004
    ..To determine whether a history of a previous aneuploid conception increases the rate of aneuploidy among women having preimplantation diagnosis (PGD)...
  37. ncbi request reprint Sperm and blastomere aneuploidy detection in reproductive genetics and medicine
    Luca Gianaroli
    S I S Me R, Reproductive Medicine Unit, Via Mazzini, 123 40138 Bologna, Italy
    J Histochem Cytochem 53:261-7. 2005
    ..This observation suggests that, in selected cases, the paternal contribution to aneuploidy in the developing conceptus could be more relevant than expected from general data from aborted fetuses and live births...
  38. ncbi request reprint The new Italian IVF legislation
    Giuseppe Benagiano
    Reprod Biomed Online 9:117-25. 2004
    ....
  39. ncbi request reprint Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques
    Anna Pia Ferraretti
    SISMER Reproductive Unit, Bologna, Italy
    Fertil Steril 82:1521-6. 2004
    ..To investigate the role of exogenous LH in controlled ovarian hyperstimulation for assisted reproductive technologies...
  40. ncbi request reprint The combination of polar body and embryo biopsy does not affect embryo viability
    M Cristina Magli
    S I S Me R, Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 19:1163-9. 2004
    ..The biopsy of both polar bodies and a blastomere from the same embryo was investigated as an approach aimed at increasing the quantity of DNA available for genetic analysis in preimplantation embryos...
  41. ncbi request reprint Topology of chromosomes 18 and X in human blastomeres from 3- to 4-day-old embryos
    Jan Diblík
    Institute of Biology and Medical Genetics, University Hospital Motol, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
    J Histochem Cytochem 53:273-6. 2005
    ..0013) and aneuploid/euploid blastomeres (p=0.0011). No differences were found in localization of chromosome 18 in euploid and in chromosome X in euploid and aneuploid blastomeres...
  42. ncbi request reprint Effect of inner myometrium fibroid on reproductive outcome after IVF
    Luca Gianaroli
    SISMeR Reproductive Medicine Unit, Via Mazzini, 12 40138 Bologna, Italy
    Reprod Biomed Online 10:473-7. 2005
    ..Whether this classification will be superior in predicting the impact of fibroids on the reproductive outcome should be elaborated in a large multicentric study...
  43. ncbi request reprint The beneficial effects of preimplantation genetic diagnosis for aneuploidy support extensive clinical application
    Luca Gianaroli
    S I S Me R, Reproductive Medicine Unit, Bologna, Italy
    Reprod Biomed Online 10:633-40. 2005
    ..001) take-home baby rate when compared with the previous reproductive history of the parents...
  44. ncbi request reprint Over a decade of experience with preimplantation genetic diagnosis
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted, Chicago, IL 60657, USA
    Fertil Steril 82:302-3. 2004
    ..e., microarray analysis), and more refined patient selection may be required before shifting from preselection of embryos based solely on morphological parameters to transfer of only aneuploidy-free embryos...
  45. ncbi request reprint Guidelines for the appropriate use of genetic tests in infertile couples
    Carlo Foresta
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, Via Ospedale 105, 35128 Padova, Italy
    Eur J Hum Genet 10:303-12. 2002
    ..We examine the clinically relevant genetic causes of male and female infertility and suggest the category of patients for which each genetic test is recommended or optional, both for an accurate diagnosis and prior to ART...
  46. ncbi request reprint Over a decade of experience with preimplantation genetic diagnosis: a multicenter report
    Yury Verlinsky
    Reproductive Genetics Institute, 2825 North Halsted, Chicago, IL 60657, USA
    Fertil Steril 82:292-4. 2004
    ..To review a 12-year experience of the world's three largest preimplantation genetic diagnosis (PGD) centers...
  47. ncbi request reprint Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia
    Giorgio Cavallini
    Headquarters of Società Italiana di Studi di Medicina della Riproduzione SISMER, Bologna, Italy
    J Androl 25:761-70; discussion 771-2. 2004
    ..Pregnancy rates were 1.7% (group 1), 21.8% (group 2), and 38.0% (group 3) (P <.01). L-carnitine/acetyl-L-carnitine + cinnoxicam suppositories proved a reliable treatment for low-grade varicoceles and idiopathic OATs...
  48. doi request reprint Revised guidelines for good practice in IVF laboratories
    M Cristina Magli
    UZ Brussel, Centre for Reproductive Medicine, Laarbeeklaan 101, Brussels 1090, Belgium
    Hum Reprod 23:1253-62. 2008
    ..The SIG in Embryology hopes that this document may assist the laboratory staff to operate according to the requirements of harmonization, implementation, inspection and certification that are now common to all European member states...
  49. doi request reprint Gene expression profiling of human oocytes following in vivo or in vitro maturation
    Gayle M Jones
    Monash Immunology and Stem Cell Laboratories, Monash University, Level 3, STRIP Building 75 Wellington Road, Clayton, VIC 3800, Australia
    Hum Reprod 23:1138-44. 2008
    ..This developmental incompetence has been explained as poor oocyte cytoplasmic maturation without any determination of the likely molecular basis of this observation...
  50. ncbi request reprint High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome
    Jan Brosens
    Institute for Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Hum Reprod 19:352-6. 2004
    ..Aromatase P450 expression in the human endometrium is thought to be restricted to women with proliferative reproductive tract disorders such as endometriosis, leiomyomas and adenomyosis...
  51. ncbi request reprint Discussion (day 2 session 4): Lessons on ART from philosophy, religion and politics
    Julian Savulescu
    Reprod Biomed Online 10:144-6. 2005
  52. ncbi request reprint The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues
    Sirpa Soini
    Department of Medical Genetics, University of Turku, Turku, Finland, and Archbishop Hospital and Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Eur J Hum Genet 14:588-645. 2006
    ..Technical, social, ethical and legal issues of ART and genetics will be reviewed...