F Regoli

Summary

Country: Italy

Publications

  1. ncbi request reprint Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguilla
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, 60100 Ancona, Italy
    Environ Toxicol Chem 22:2120-9. 2003
  2. ncbi request reprint Variations of antioxidant efficiency and presence of endosymbiotic diatoms in the Antarctic porifera Haliclona dancoi
    F Regoli
    Istituto Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, Ancona 60100, Italy
    Mar Environ Res 58:637-40. 2004
  3. ncbi request reprint Time-course variations of oxyradical metabolism, DNA integrity and lysosomal stability in mussels, Mytilus galloprovincialis, during a field translocation experiment
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Aquat Toxicol 68:167-78. 2004
  4. ncbi request reprint Antioxidant efficiency in early life stages of the Antarctic silverfish, Pleuragramma antarcticum: responsiveness to pro-oxidant conditions of platelet ice and chemical exposure
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Aquat Toxicol 75:43-52. 2005
  5. ncbi request reprint Analysis of vitellogenin gene induction as a valuable biomarker of estrogenic exposure in various Mediterranean fish species
    M Barucca
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Environ Res 101:68-73. 2006
  6. ncbi request reprint Trace metal concentrations and susceptibility to oxidative stress in the polychaete Sabella spallanzanii (Gmelin) (Sabellidae): potential role of antioxidants in revealing stressful environmental conditions in the Mediterranean
    R Bocchetti
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Via Ranieri, Monte D Ago, 1 60100 Ancona, Italy
    Arch Environ Contam Toxicol 46:353-61. 2004
  7. doi request reprint Biological effects of palytoxin-like compounds from Ostreopsis cf. ovata: a multibiomarkers approach with mussels Mytilus galloprovincialis
    S Gorbi
    Dipartimento di Scienze della Vita e dell Ambiente, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Chemosphere 89:623-32. 2012
  8. ncbi request reprint Preliminary investigations on vitellogenin m-RNA induction in some bioindicator Mediterranean fish species
    A Canapa
    Istituto Biologia e Genetica, Universita di Ancona, Italy
    Mar Environ Res 54:673-7. 2002
  9. ncbi request reprint Oxidative stress in ecotoxicology: from the analysis of individual antioxidants to a more integrated approach
    F Regoli
    Istituto di Biologia e Genetica, Universita di Ancona, Italy
    Mar Environ Res 54:419-23. 2002
  10. doi request reprint Effect of biologic therapies targeting tumour necrosis factor-α on cutaneous mesenchymal stem cells in psoriasis
    A Campanati
    Dermatological Clinic, Department of Molecular and Clinical Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Br J Dermatol 167:68-76. 2012

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguilla
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, 60100 Ancona, Italy
    Environ Toxicol Chem 22:2120-9. 2003
    ..These data suggest a general relationship between oxidative stress and loss of DNA integrity in juvenile eels exposed to the chemicals studied herein...
  2. ncbi request reprint Variations of antioxidant efficiency and presence of endosymbiotic diatoms in the Antarctic porifera Haliclona dancoi
    F Regoli
    Istituto Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, Ancona 60100, Italy
    Mar Environ Res 58:637-40. 2004
    ..The efficiency of antioxidant defenses in the sponge showed a marked response to symbionts with clearly enhanced values corresponding to the peak of diatoms...
  3. ncbi request reprint Time-course variations of oxyradical metabolism, DNA integrity and lysosomal stability in mussels, Mytilus galloprovincialis, during a field translocation experiment
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Aquat Toxicol 68:167-78. 2004
    ....
  4. ncbi request reprint Antioxidant efficiency in early life stages of the Antarctic silverfish, Pleuragramma antarcticum: responsiveness to pro-oxidant conditions of platelet ice and chemical exposure
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Aquat Toxicol 75:43-52. 2005
    ....
  5. ncbi request reprint Analysis of vitellogenin gene induction as a valuable biomarker of estrogenic exposure in various Mediterranean fish species
    M Barucca
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Environ Res 101:68-73. 2006
    ..thynnus (>100 kg), supporting estrogenic exposure of older specimens. In this species two different VTGs were identified, and the sequences obtained in the various species were compared with available sequences...
  6. ncbi request reprint Trace metal concentrations and susceptibility to oxidative stress in the polychaete Sabella spallanzanii (Gmelin) (Sabellidae): potential role of antioxidants in revealing stressful environmental conditions in the Mediterranean
    R Bocchetti
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Via Ranieri, Monte D Ago, 1 60100 Ancona, Italy
    Arch Environ Contam Toxicol 46:353-61. 2004
    ..Our results confirm the role of antioxidants in adaptation to stressful environmental conditions and their importance in ecotoxicological studies for the sensitivity in revealing the occurrence of biological disturbance...
  7. doi request reprint Biological effects of palytoxin-like compounds from Ostreopsis cf. ovata: a multibiomarkers approach with mussels Mytilus galloprovincialis
    S Gorbi
    Dipartimento di Scienze della Vita e dell Ambiente, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Chemosphere 89:623-32. 2012
    ..This study provided preliminary results on the usefulness of a multi-biomarker approach to assess biological alterations and toxicological events associated to blooms of O. cf. ovata in marine organisms...
  8. ncbi request reprint Preliminary investigations on vitellogenin m-RNA induction in some bioindicator Mediterranean fish species
    A Canapa
    Istituto Biologia e Genetica, Universita di Ancona, Italy
    Mar Environ Res 54:673-7. 2002
    ..The analysis of vitellogenin mRNA levels has been standardized in feral fish providing suitable indications for a future development of this approach...
  9. ncbi request reprint Oxidative stress in ecotoxicology: from the analysis of individual antioxidants to a more integrated approach
    F Regoli
    Istituto di Biologia e Genetica, Universita di Ancona, Italy
    Mar Environ Res 54:419-23. 2002
    ..TOSC has a greater predictive value on the health condition of the organisms and allows to discriminate the different role of specific ROS in oxidative stress syndrome...
  10. doi request reprint Effect of biologic therapies targeting tumour necrosis factor-α on cutaneous mesenchymal stem cells in psoriasis
    A Campanati
    Dermatological Clinic, Department of Molecular and Clinical Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Br J Dermatol 167:68-76. 2012
    ..Reactive oxygen species actively promote the secretion of inflammatory Th1 cytokines directly involved in the pathogenesis of psoriasis...
  11. pmc Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Environ Health Perspect 114:63-9. 2006
    ..Key words: atmospheric pollutants, bioindicators, biomarkers, DNA integrity, lysosomes, metallothioneins, oxidative stress, peroxisomes, polycyclic aromatic hydrocarbons, trace metals...
  12. ncbi request reprint Short-term responses to cadmium exposure in the estuarine polychaete Laeonereis acuta (polychaeta, Nereididae): subcellular distribution and oxidative stress generation
    Juliana Zomer Sandrini
    Departamento de Ciencias Fisiologicas, Fundacao Universidade Federal do Rio Grande, Brasil
    Environ Toxicol Chem 25:1337-44. 2006
    ..The effects caused by cadmium in the present study were observed only after 8 h of exposure, demonstrating that cadmium can generate oxidative stress...
  13. ncbi request reprint Influence of the SCGE protocol on the amount of basal DNA damage detected in the Mediterranean mussel, Mytilus galloprovincialis
    Nicola Machella
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Environ Mol Mutagen 47:579-86. 2006
    ..M. galloprovincialis is used extensively as a sentinel species for assessing the genotoxic hazard of marine pollutants. Our data suggest that the SCGE protocol should be carefully considered when assessing DNA damage in these species...
  14. ncbi request reprint Seasonal variability of oxidative biomarkers, lysosomal parameters, metallothioneins and peroxisomal enzymes in the Mediterranean mussel Mytilus galloprovincialis from Adriatic Sea
    Raffaella Bocchetti
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Chemosphere 65:913-21. 2006
    ....
  15. ncbi request reprint Toxicological responses in Laeonereis acuta (annelida, polychaeta) after arsenic exposure
    Juliane Ventura-Lima
    Departamento de Ciencias Fisiologicas, Fundação Universidade Federal do Rio Grande FURG, Rio Grande, RS, Brazil
    Environ Int 33:559-64. 2007
    ..acuta, although the high levels of inorganic As suggest that not all the administered As(III) (as As(2)O(3)) is completely removed or biotransformed after 7 days of exposure...
  16. ncbi request reprint Antioxidant responses in the nereidid Laeonereis acuta (Annelida, Polychaeta) after cadmium exposure
    Juliana Zomer Sandrini
    Programa de Pós Graduação em Ciências Fisiológicas Fisiologia Animal Comparada PPGCF FAC, FURG, Brazil
    Ecotoxicol Environ Saf 70:115-20. 2008
    ..05) by the exposition to cadmium. Thus, cadmium can augment RONS levels and can interfere with the antioxidant defense system of the polychaete L. acuta, although cadmium does not directly induce oxidative stress unlike copper and iron...
  17. ncbi request reprint Presence and inducibility by beta-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus bernacchii, an Antarctic fish
    Domenica Di Bello
    Dipartimento di Patologia Animale Profilassi ed Igiene degli Alimenti, Universita di Pisa, Viale delle Piagge 2, 56124 Pisa, Italy
    Aquat Toxicol 84:19-26. 2007
    ..Obtained results represent an additional contribution to the ecotoxicological characterization of T. bernacchii and further support the use of biomarkers for early detection of chemical pollution in Antarctica...
  18. ncbi request reprint An ecotoxicological protocol with caged mussels, Mytilus galloprovincialis, for monitoring the impact of an offshore platform in the Adriatic Sea
    Stefania Gorbi
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Mar Environ Res 65:34-49. 2008
    ....
  19. ncbi request reprint Oxidative and modulatory effects of trace metals on metabolism of polycyclic aromatic hydrocarbons in the Antarctic fish Trematomus bernacchii
    Maura Benedetti
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Aquat Toxicol 85:167-75. 2007
    ..In general, the overall results revealed a complex pathway of interactions between different chemicals during co-exposures and the importance of oxidative status in modulating induction and expression of CYP1A1...
  20. doi request reprint Ecotoxicological and human health risk in a petrochemical district of southern Italy
    Antonella Ausili
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Mar Environ Res 66:215-7. 2008
    ..Such toxicological risk is of particular importance for pregnant women, being possibly involved in the elevated frequency of neonatal malformations...
  21. doi request reprint Seasonal variations of exposure biomarkers, oxidative stress responses and cell damage in the clams, Tapes philippinarum, and mussels, Mytilus galloprovincialis, from Adriatic sea
    Raffaella Bocchetti
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Montedago 65, Ancona, Italy
    Mar Environ Res 66:24-6. 2008
    ..Overall results indicated a significant influence of seasonal variability on several biomarkers and species-specific differences which should be considered to discriminate the appearance of anthropogenic disturbance...
  22. doi request reprint Seasonal, spatial and inter-annual variations of trace metals in mussels from the Adriatic sea: a regional gradient for arsenic and implications for monitoring the impact of off-shore activities
    Daniele Fattorini
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Montedago 65, 60131 Ancona, Italy
    Chemosphere 72:1524-33. 2008
    ..The overall results confirmed the importance of natural variability when assessing the potential impact of anthropogenic activities...
  23. ncbi request reprint Vitellogenin gene expression in males of the Antarctic fish Trematomus bernacchii from Terra Nova Bay (Ross Sea): a role for environmental cadmium?
    Adriana Canapa
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Chemosphere 66:1270-7. 2007
    ..Although molecular mechanisms of VTG gene expression in males of T. bernacchii remain unclear, obtained results provide interesting insights on this species which should stimulate future research activities...
  24. ncbi request reprint Interactions between metabolism of trace metals and xenobiotic agonists of the aryl hydrocarbon receptor in the antarctic fish Trematomus bernacchii: environmental perspectives
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Environ Toxicol Chem 24:1475-82. 2005
    ....
  25. ncbi request reprint Seasonal variability of metallothioneins, cytochrome P450, Bile metabolites and oxyradical metabolism in the European eel Anguilla anguilla L. (Anguillidae) and striped mullet Mugil cephalus L. (Mugilidae)
    Stefania Gorbi
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Arch Environ Contam Toxicol 49:62-70. 2005
    ..This study confirms the importance of characterizing seasonal variations and the influence of different factors on biological responses that can be used as biomarkers in monitoring programs...
  26. ncbi request reprint A comparative study of the in vitro antioxidant activity of statins
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Int J Cardiol 90:317-21. 2003
    ..The aim of this study was to assess the total antioxidant activity of the most prescribed statins: fluvastatin, atorvastatin, pravastatin and simvastatin...
  27. ncbi request reprint Application of biomarkers for assessing the biological impact of dredged materials in the Mediterranean: the relationship between antioxidant responses and susceptibility to oxidative stress in the red mullet (Mullus barbatus)
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita di Ancona, Italy
    Mar Pollut Bull 44:912-22. 2002
    ..The red mullet appears to be a useful sentinel species for a biomarker approach to monitoring impact caused by dredged materials...
  28. ncbi request reprint Application of an immunoperoxidase staining method for detection of 7,8-dihydro-8-oxodeoxyguanosine as a biomarker of chemical-induced oxidative stress in marine organisms
    Nicola Machella
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri 65, Monte D Ago, 60100 Ancona, Italy
    Aquat Toxicol 67:23-32. 2004
    ....
  29. ncbi request reprint Antioxidant efficiency and detoxification enzymes in spotted dogfish Scyliorhinus canicula
    Stefania Gorbi
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Mar Environ Res 58:293-7. 2004
    ..S. canicula showed significantly lower antioxidant enzymes and a more reduced efficiency in neutralizing *OH; on the other hand the scavenging capability toward ROO* was comparable in S. canicula and M. barbatus...
  30. ncbi request reprint Induction of cytochrome P4501A and biliary PAH metabolites in European eel Anguilla anguilla: Seasonal, dose- and time-response variability in field and laboratory conditions
    Stefania Gorbi
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, Ancona 60100, Italy
    Mar Environ Res 58:511-5. 2004
    ....
  31. ncbi request reprint Time-course evaluation of ROS-mediated toxicity in mussels, Mytilus galloprovincialis, during a field translocation experiment
    Giada Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, Universita di Pisa, Italy
    Mar Environ Res 58:609-13. 2004
    ..Results showed a biphasic trend for single antioxidants and TOSC, with an increase during the first 2 weeks of exposure to the polluted site followed by a progressive decrease up to a severe depletion in the final part of the experiment...
  32. ncbi request reprint Total oxyradical scavenging capacity toward different reactive oxygen species in seminal plasma and sperm cells
    Giancarlo Balercia
    Endocrinology, Department of Internal Medicine, University of Ancona, Ancona, Italy
    Clin Chem Lab Med 41:13-9. 2003
    ..e., hydroxyl radicals, in altering sperm motility. Measurement of TOSC is suggested as a useful means of indicating relationship between reactive oxygen species and sperm cell kinetics in clinical trials and antioxidant-based treatments...
  33. ncbi request reprint Chemical speciation of arsenic in different marine organisms: Importance in monitoring studies
    Daniele Fattorini
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Mar Environ Res 58:845-50. 2004
    ..Fish from the more impacted site were characterized by elevated concentrations of arsenic (up to 500 microg/g d.w.) and inorganic species represented the predominant forms in muscle tissues of these organisms...
  34. ncbi request reprint Pro-oxidant effects of extremely low frequency electromagnetic fields in the land snail Helix aspersa
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri, Monte D Ago, 60121 Ancona, Italy
    Free Radic Biol Med 39:1620-8. 2005
    ....
  35. ncbi request reprint Immunofluorescent detection of 8-oxo-dG and PAH bulky adducts in fish liver and mussel digestive gland
    Nicola Machella
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri 65, Monte D Ago, 60100 Ancona, Italy
    Aquat Toxicol 71:335-43. 2005
    ..Although field validation is being carried out, our results indicate the utility of antibodies to rapidly detect DNA alterations in aquatic organisms, and to investigate the risk associated with genotoxins in marine environment...
  36. ncbi request reprint Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 18:510-6. 2005
    ..The aim of this study was to evaluate the relationship between long-term physical activity, plasma antioxidant status, and conduit artery endothelial function in young and older healthy men...
  37. ncbi request reprint Oxidative damage to DNA: an immunohistochemical approach for detection of 7,8-dihydro-8-oxodeoxyguanosine in marine organisms
    Nicola Machella
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri 65, Monte D Ago, 60100 Ancona, Italy
    Mar Environ Res 58:725-9. 2004
    ..These results suggest that the assay should have practical applications in marine ecotoxicology...
  38. ncbi request reprint An in vitro study of the peroxyl and hydroxyl radical scavenging capacity of the calcium antagonist amlodipine
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Biomed Pharmacother 58:423-6. 2004
    ..Amlodipine has intrinsic antioxidant activity with both anti-hydroxyl and anti-peroxyl radicals activity...
  39. ncbi request reprint Plasma antioxidant activity and cutaneous microvascular endothelial function in athletes and sedentary controls
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Biomed Pharmacother 58:432-6. 2004
    ..r = 0.41, P <0.01). In conclusion, these results suggest that regular physical activity is associated with a better microvascular endothelial function in older athletes probably due to increased antioxidant defenses...
  40. ncbi request reprint Arsenic speciation in tissues of the Mediterranean polychaete Sabella spallanzanii
    Daniele Fattorini
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Environ Toxicol Chem 23:1881-7. 2004
    ....
  41. ncbi request reprint Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia
    Giancarlo Balercia
    Department of Internal Medicine, Polytechnic University of Marche, Ancona, Italy
    Fertil Steril 84:662-71. 2005
    ..To evaluate the effectiveness of L-carnitine (LC) or L-acetyl-carnitine (LAC) or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen...
  42. ncbi request reprint Total content and chemical speciation of arsenic in the polychaete Sabella spallanzanii
    Daniele Fattorini
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Mar Environ Res 58:839-43. 2004
    ..w.) and chemical speciation revealed that the predominant form was the relatively toxic dimethylarsinate (DMA). These data suggest a potential role of As as anti-predatory strategy in polychaetes...