C J Wiedermann

Summary

Affiliation: Regional Hospital
Country: Italy

Publications

  1. ncbi Reporting bias in trials of volume resuscitation with hydroxyethyl starch
    Christian J Wiedermann
    Academic Teaching Department of Internal Medicine, Central Hospital of Bozen Bolzano, Lorenz Böhler Street 5, 39100, Bozen Bolzano BZ, Italy
    Wien Klin Wochenschr 126:189-94. 2014
  2. doi Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100, Bolzano, Italy
    Intensive Care Med 40:160-70. 2014
  3. doi From persistence to palliation: limiting active treatment in the ICU
    Christian J Wiedermann
    Department of Internal Medicine, Academic Teaching Hospital, Central Hospital of Bolzano, Bolzano, Italy
    Curr Opin Crit Care 18:693-9. 2012
  4. doi Mortality after hydroxyethyl starch 130/0.4 infusion: an updated meta-analysis of randomized trials
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Swiss Med Wkly 142:w13656. 2012
  5. pmc Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis
    Jordan Kountchev
    Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Austria
    Crit Care 9:R596-600. 2005
  6. pmc The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy, Bolzano, Italy
    BMC Med Genet 8:29. 2007
  7. pmc Immunomodulation by alpha(1)-proteinase inhibitor: lack of chemotactic effects of recombinant human alpha(1)-proteinase inhibitor from yeast on human peripheral blood granulocytes
    Birgit Mosheimer
    Division of General Internal Medicine, Department of Medicine, Medical University of Innsbruck, A 6020, Innsbruck, Austria
    Arch Immunol Ther Exp (Warsz) 55:399-403. 2007
  8. doi Reduced watery diarrhea during pregnancy in a psoriasis patient with lymphocytic colitis
    C J Wiedermann
    Divison of Internal Medicine 2, Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Z Gastroenterol 46:1275-7. 2008
  9. pmc Fatal cardiac arrest in an adult patient with euthyroid anti-SSA/Ro-positive connective tissue disease: a case report
    Michele Adami
    Department of Internal Medicine, Central Hospital of Bolzano, , IT 39100 Bolzano, Italy
    Int Arch Med 2:15. 2009
  10. doi Warfarin-induced bleeding complications - clinical presentation and therapeutic options
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Thromb Res 122:S13-8. 2008

Collaborators

Detail Information

Publications91

  1. ncbi Reporting bias in trials of volume resuscitation with hydroxyethyl starch
    Christian J Wiedermann
    Academic Teaching Department of Internal Medicine, Central Hospital of Bozen Bolzano, Lorenz Böhler Street 5, 39100, Bozen Bolzano BZ, Italy
    Wien Klin Wochenschr 126:189-94. 2014
    ..In conclusion, selective outcome reporting bias is identified in recent publications of clinical trials on volume resuscitation with HES. ..
  2. doi Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100, Bolzano, Italy
    Intensive Care Med 40:160-70. 2014
    ..To systematically review clinical and preclinical data on hydroxyethyl starch (HES) tissue storage...
  3. doi From persistence to palliation: limiting active treatment in the ICU
    Christian J Wiedermann
    Department of Internal Medicine, Academic Teaching Hospital, Central Hospital of Bolzano, Bolzano, Italy
    Curr Opin Crit Care 18:693-9. 2012
    ..This narrative review describes recent studies on how to improve palliative care and surrogate decision-making in ICUs and compares the results with previously published literature on this topic...
  4. doi Mortality after hydroxyethyl starch 130/0.4 infusion: an updated meta-analysis of randomized trials
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Swiss Med Wkly 142:w13656. 2012
    ..4. As results from new trials, reporting on a large number of events became available in 2011 and 2012, an updated meta-analysis was performed...
  5. pmc Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis
    Jordan Kountchev
    Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Austria
    Crit Care 9:R596-600. 2005
    ..In the present study, we report on changes in circulating levels of D-dimer in response to administration of AT in a series of patients with acquired AT deficiency due to severe sepsis...
  6. pmc The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy, Bolzano, Italy
    BMC Med Genet 8:29. 2007
    ..For historical and political reasons, South Tyrol, the northern most Italian region, includes several villages of small dimensions which remained isolated over the centuries...
  7. pmc Immunomodulation by alpha(1)-proteinase inhibitor: lack of chemotactic effects of recombinant human alpha(1)-proteinase inhibitor from yeast on human peripheral blood granulocytes
    Birgit Mosheimer
    Division of General Internal Medicine, Department of Medicine, Medical University of Innsbruck, A 6020, Innsbruck, Austria
    Arch Immunol Ther Exp (Warsz) 55:399-403. 2007
    ..The migratory effects of yeast-derived human recombinant alpha(1)-proteinase inhibitor on human peripheral blood neutrophils and eosinophils were therefore tested in vitro...
  8. doi Reduced watery diarrhea during pregnancy in a psoriasis patient with lymphocytic colitis
    C J Wiedermann
    Divison of Internal Medicine 2, Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Z Gastroenterol 46:1275-7. 2008
    ..This clinical observation suggests that pregnancy influences the overall course of chronic watery diarrhea of autoimmune-associated microscopic colitis...
  9. pmc Fatal cardiac arrest in an adult patient with euthyroid anti-SSA/Ro-positive connective tissue disease: a case report
    Michele Adami
    Department of Internal Medicine, Central Hospital of Bolzano, , IT 39100 Bolzano, Italy
    Int Arch Med 2:15. 2009
    ..CONCLUSION: This case might indicate that, although the adult heart conduction system may be relatively resistant to the development of anti-Ro-associated complete heart block, cardiac arrest may develop and even be fatal...
  10. doi Warfarin-induced bleeding complications - clinical presentation and therapeutic options
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Thromb Res 122:S13-8. 2008
    ..Other advantages of PCC over FFP include smaller infusion volumes, no blood group testing and virus-inactivated blood product...
  11. pmc Enhancement of fibrinogen-triggered pro-coagulant activation of monocytes in vitro by matrix metalloproteinase-9
    Nicole C Kaneider
    Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano BZ, Italy
    Thromb J 8:2. 2010
    ....
  12. ncbi Hydroxyethyl starch--can the safety problems be ignored?
    Christian J Wiedermann
    2nd Department of Internal Medicine, Central Hospital of Bolzano Bozen, Bolzano, Italy
    Wien Klin Wochenschr 116:583-94. 2004
    ..Limiting the dose and duration of HES therapy may be helpful in lessening the risk of undesired side effects; at present however, reliance on particular HES solutions does not appear sufficient to ensure safety...
  13. ncbi [Endogenous anticoagulant therapy for sepsis. Success and failure]
    C J Wiedermann
    Abteilung fur Innere Medizin, Zentralkrankenhaus und Akademisches Lehrkrankenhaus der Medizinischen Universität Innsbruck in Bozen, L Böhler Strasse 5, 39100 Bozen
    Internist (Berl) 48:537-42, 544. 2007
    ....
  14. ncbi A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis
    Christian J Wiedermann
    Division of Internal Medicine II, Department of Medicine, Central Hospital of Bolzano, Bolzano Bozen, Italy
    Blood Coagul Fibrinolysis 17:521-6. 2006
    ..In sepsis patients with DIC, administration of antithrombin concentrate may increase overall survival. Current available evidence, however, is not suited to sufficiently inform clinical practice...
  15. pmc Clinical review: molecular mechanisms underlying the role of antithrombin in sepsis
    Christian J Wiedermann
    2nd Divison of Internal Medicine, Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Crit Care 10:209. 2006
    ..Final assessment of the drug's effectiveness, however, must await the availability of positive, prospective, randomized and placebo-controlled studies...
  16. ncbi Bioethics, the Surviving Sepsis Campaign, and the industry
    Christian J Wiedermann
    Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Wien Klin Wochenschr 117:442-4. 2005
  17. doi Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies
    Christian J Wiedermann
    Division of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy
    Intensive Care Med 36:1657-65. 2010
    ..To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI)...
  18. doi Digital clubbing in primary intestinal lymphangiectasia: a case report
    Christian J Wiedermann
    Division of Internal Medicine, Central Hospital, Bolzano, Italy
    Wien Med Wochenschr 160:431-6. 2010
    ..Digital clubbing associated with primary intestinal lymphangiectasia which may causally be related to chronic platelet excess has not been reported before...
  19. doi Awareness and use of recommendations for withholding and withdrawing therapy in Austrian intensive care units
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano BZ, Italy
    Wien Med Wochenschr 161:99-102. 2011
    ..Even though the response rate was low, Austrian intensive care medicine societies should be encouraged to better disseminate end-of-life decision guidelines among caregivers...
  20. doi Bacillus species infective arthritis after knee arthroscopy
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Surg Infect (Larchmt) 11:555-8. 2010
    ..Bacillus species infection of the joints is a very rare occurrence, with sporadic reports in the medical literature...
  21. pmc Hyperoncotic colloids and acute kidney injury: a meta-analysis of randomized trials
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy
    Crit Care 14:R191. 2010
    ..It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear...
  22. pmc Mesenteric panniculitis presenting with acute non-occlusive colonic ischemia
    Florian Amor
    Division of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, Bolzano 39100, Italy
    Int Arch Med 4:22. 2011
    ..abstract:..
  23. doi [Volume replacement therapy options for critically ill patients]
    C J Wiedermann
    Abteilung fur Innere Medizin, Zentralkrankenhaus Bozen, Italien
    Med Klin Intensivmed Notfmed 106:53-64; quiz 65-6. 2011
    ..Artificial colloids (hydroxyethyl starch) are cheaper than the natural colloid albumin but the safety profile is less favorable...
  24. ncbi [Scoring of disseminated intravascular coagulation (DIC) in intensive care medicine]
    C J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano BZ, Italy
    Clin Ter 159:275-81. 2008
    ..Early detection of DIC by application of novel scores could play a particular role in future DIC trials by defining patient populations most likely to benefit from targeted intervention in their clotting disturbance of critical illness...
  25. ncbi Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study
    C J Wiedermann
    Department of Internal Medicine, Medical Faculty, University of Innsbruck, Austria
    J Am Coll Cardiol 34:1975-81. 1999
    ..Focus of the current study was on the significance of bacterial endotoxin, which shows a variety of pro-atherogenic properties and may occur at high concentration in the circulation of infected subjects...
  26. ncbi Cell-surface heparan sulfate proteoglycan-mediated regulation of human neutrophil migration by the serpin antithrombin III
    S Dunzendorfer
    Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria, and Aventis Behring GmbH Research, Marburg, Germany
    Blood 97:1079-85. 2001
    ..Under physiological conditions, AT III may prevent neutrophils from premature activation. Moreover, the systemic administration of AT III concentrate could have beneficial effects in combating systemic inflammation...
  27. ncbi Syndecan-4-dependent migration of human eosinophils
    C Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    Clin Exp Allergy 34:696-703. 2004
    ..They modulate inflammatory cell maturation and activation, leucocyte rolling, adhesion to endothelium as well as extravasation and chemotaxis. Whether eosinophil's function is affected has not yet been reported...
  28. ncbi Secretoneurin and neurogenic inflammation
    C J Wiedermann
    Laboratory of Intensive Care Medicine, Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Zhongguo Yao Li Xue Bao 20:789-94. 1999
    ..Review of evidence that the 33-amino-acid polypeptide secretoneurin, which is generated by proteolytic cleavage of secretogranin II, plays a role in neurogenic inflammation...
  29. ncbi Plasma-induced endothelial activation associated with incident atherosclerosis: prospective results from the Bruneck Study
    P Schratzberger
    Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Austria
    J Cardiovasc Risk 7:285-91. 2000
    ..Whether systemic inflammation is an epiphenomenon of atherosclerosis or whether it is part of the atherosclerosis causal pathway requires further study...
  30. ncbi Induction of apoptosis and inhibition of migration of inflammatory and vascular wall cells by cerivastatin
    N C Kaneider
    Division of General Internal Medicine, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    Atherosclerosis 158:23-33. 2001
    ..In addition to its lipid-lowering effects, pharmacological properties of cerivastatin may include modulatory actions in leukocytes and mesenchymal cells...
  31. ncbi Induction of arachidonic acid metabolite release by human fibroblasts in proliferative vitreoretinopathy
    C M Kahler
    Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Austria
    Eur J Pharmacol 341:111-7. 1998
    ....
  32. ncbi Cutting edge: peripheral neuropeptides attract immature and arrest mature blood-derived dendritic cells
    S Dunzendorfer
    Divisions of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    J Immunol 166:2167-72. 2001
    ..It seems that one function of sensory nerves is to fasten DC at sites of inflammation...
  33. ncbi Protein kinase C-dependent effects on leukocyte migration of thalidomide
    C Meierhofer
    Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
    J Infect Dis 180:216-9. 1999
    ..Results suggest that effects of thalidomide in chronic inflammation may be related to actions on leukocyte functions...
  34. ncbi Influence of neuropeptides on neutrophil adhesion and transmigration through a lung fibroblast barrier in vitro
    C M Kahler
    Department of Internal Medicine, Division of General Internal Medicine Pulmonology and ICU, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
    Exp Lung Res 27:25-46. 2001
    ..In conclusion, SP in concert with proinflammatory cytokines may regulate neutrophil interstitial accumulation and their traffic to the alveolar space in lung inflammation...
  35. ncbi Hypersensitivity reactions associated with recombinant tissue-type plasminogen activator and urokinase
    C Pechlaner
    Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria
    Blood Coagul Fibrinolysis 12:491-4. 2001
    ..Steroids do not prevent, but histamine receptor blockers seem to be an effective treatment of this unusual complication of thrombolytic therapy...
  36. ncbi Elimination of levofloxacin in critically ill patients with renal failure: influence of continuous veno-venous hemofiltration
    R Bellmann
    Department of Internal Medicine, University of Innsbruck, Austria
    Int J Clin Pharmacol Ther 40:142-9. 2002
    ..Pharmacokinetic data on levofloxacin in critically ill patients are sparse and conflicting. Aim of the study was to assess the clearance of levofloxacin in critically ill patients treated with continuous veno-venous hemofiltration (CVVH)...
  37. ncbi The inhibition of oxygen radical release from human neutrophils by resting platelets is reversed by administration of acetylsalicylic acid or clopidogrel
    C M Reinisch
    Medical Intensive Care Unit, Division of General Internal Medicine, Department of Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Free Radic Res 34:461-6. 2001
    ..Results suggest that the protective role of resting platelets in controlling oxygen radical release from neutrophils in the absence of platelet activation may be impaired by antiplatelet therapy...
  38. ncbi The role of immune activation in endotoxin-induced atherogenesis
    C J Wiedermann
    Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
    J Endotoxin Res 7:322-6. 2001
    ..The study provides epidemiological evidence that the atherogenic potential of endotoxemia is affected by concomitant immune activation...
  39. ncbi Incidence and risk of potential adverse drug interactions in the emergency room
    D Heininger Rothbucher
    Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Resuscitation 49:283-8. 2001
    ..Safeguards need to be introduced to prevent patients from receiving medications in the emergency departments that have the potential to cause adverse interactions...
  40. ncbi Functional expression of chemokine receptor 2 by normal human eosinophils
    S Dunzendorfer
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Austria
    J Allergy Clin Immunol 108:581-7. 2001
    ..In vivo administration of neutralizing anti-monocyte chemoattractant protein 1 (MCP-1) antibodies can block accumulation of eosinophils in the lungs of antigen-challenged animals...
  41. ncbi Secretoneurin: a functional neuropeptide in health and disease
    C J Wiedermann
    Department of Internal Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
    Peptides 21:1289-98. 2000
    ..With an array of actions as diverse as that seen with other sensory neuropeptides, there is scope for numerous studies and therapeutic possibilities...
  42. ncbi Plasma levels of procalcitonin and interleukin-6 in acute myocardial infarction
    T Buratti
    Department of Internal Medicine, University of Innsbruck, Austria
    Inflammation 25:97-100. 2001
    ..This observation may support the role of procalcitonin measurements in the differential diagnosis of infectious and cardiovascular complications after major surgery...
  43. doi [Minimizing perioperative risk - an interdisciplinary effort]
    Matthias Bock
    Dienst für Anästhesie und Intensivmedizin, Zentralkrankenhaus Bozen, Bozen, Italien
    Wien Med Wochenschr 158:590-4. 2008
    ..In this review, we describe the major perioperative cardiac, pulmonary and vascular risks for physicians involved in the treatment of surgical patients...
  44. pmc Patient risk factors and adverse drug interactions in the treatment of acute gouty arthritis in the elderly: a case report
    Bernhard Zagler
    Division of Internal Medicine, Department of Medicine, Central Hospital of Bolzano, L Böhler Street 5, I 39100 Bolzano BZ, Italy
    Cases J 2:6602. 2009
    ..Gastrointestinal toxicity of colchicine is dose-dependent and can be aggravated by drug-drug and drug-patient interactions...
  45. ncbi Determination of amphotericin B, liposomal amphotericin B, and amphotericin B colloidal dispersion in plasma by high-performance liquid chromatography
    P Egger
    Department of Medicine, Innsbruck University Hospital, Austria
    J Chromatogr B Biomed Sci Appl 760:307-13. 2001
    ..No interference from other drugs (typical broad medication for intensive-care patients) or common plasma components was detected in >400 samples analyzed...
  46. ncbi Nosocomial diarrhoea in adult medical patients: the role of Clostridium difficile in a North Italian acute care teaching hospital
    S Sansone
    Department of Medicine, Central Hospital of Bolzano, Italy
    J Prev Med Hyg 50:117-20. 2009
    ..Health care facilities are requested to establish rates of nosocomially acquired CDAD (N-CDAD) to understand the impact of control or prevention measures, and the burden of N-CDAD on health care resources...
  47. ncbi Baseline severity of sepsis in subjects of the prowess and the Kybersept clinical trials on endogenous anticoagulants
    Christian J Wiedermann
    Department of Internal Medicine, Central Hospital of Bolzano, Bolzano BZ, Italy
    Shock 25:657-8. 2006
  48. ncbi Contrast media-induced nephropathy in patients undergoing angiography prior to or during vascular surgery: a systematic review
    F Zaraca
    Department of Vascular and Thoracic Surgery, Central Hospital of Bolzano, Bolzano, Italy
    Minerva Chir 66:553-60. 2011
    ..Those undergoing completion angiography appear to be at even higher risk, particularly if severely azotemic. Further randomized clinical trials analyzing strategies for preventing contrast-induced nephropathy are needed...
  49. ncbi High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety
    Christian J Wiedermann
    Department of Medicine, Central Hospital of the Province of Bolzano, Bolzano, Italy
    Crit Care Med 34:285-92. 2006
    ..To explore if patients with severe sepsis and with a predicted high risk of death (according to the Simplified Acute Physiology Score II) might have a treatment benefit from high-dose antithrombin III...
  50. ncbi High-volume hemofiltration in critically ill patients: a systematic review and meta-analysis
    G F Lehner
    Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Austria
    Minerva Anestesiol 80:595-609. 2014
    ..High volume hemofiltration (HVHF) has been proposed as method for blood purification, especially under the condition of systemic inflammatory syndromes. Our goal was to evaluate the effects of HVHF in critically ill patients...
  51. ncbi Two cases of foodborne botulism with home-preserved asparagus
    P Zanon
    Department of Anesthesiology and Critical Care Medicine II, Central Hospital of Bolzano, Italy
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:156-9. 2006
    ..Despite the fact that amount of toxin ingested, time-to-symptom development, and time-to-recovery markedly differed in the two patients, their maximal disease severity was similar...
  52. ncbi Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study
    S Kiechl
    Departments of Neurology, University Clinic Innsbruck, Innsbruck, Austria
    Circulation 103:1064-70. 2001
    ..CONCLUSIONS: The present study provides solid evidence for a role of common chronic infections in human atherogenesis. Induction of systemic inflammation and autoimmunity may be potential pathophysiological links...
  53. ncbi Syndecan-4 as antithrombin receptor of human neutrophils
    N C Kaneider
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Biochem Biophys Res Commun 287:42-6. 2001
    ..In the presence of pentasaccharide, antithrombin lost its activity on the cells. Data suggest that antithrombin regulates neutrophil migration via effects of its heparin-binding site on cell surface syndecan-4...
  54. ncbi Theoretical basis for the activity of thalidomide
    C Meierhofer
    Laboratory of Intensive Care Medicine, Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
    BioDrugs 15:681-703. 2001
    ..However, despite the promising findings of thalidomide at the molecular level, namely its anti-TNFalpha properties and its intercalation with DNA, and activity in clinical trials, there is still a great need for more intensive research...
  55. doi Thromboembolism in pulmonary artery sarcoma
    Mohsen Farsad
    Department of Nuclear Medicine, Central Hospital of Bolzano, Bolzano, Italy
    Clin Nucl Med 34:239-40. 2009
    ....
  56. ncbi Effects of anticoagulant strategies on activation of inflammation and coagulation
    Clemens Feistritzer
    Medical University of Innsbruck, Department of Internal Medicine, Innsbruck Tyrol, Austria
    Expert Opin Biol Ther 7:855-70. 2007
    ....
  57. doi Early administration of high-dose antithrombin in severe sepsis: single center results from the KyberSept-trial
    Alain Eid
    Division of Pulmonary and Critical Care, CO Springs Memorial Hospital, CO Springs, Colorado, USA
    Anesth Analg 107:1633-8. 2008
    ..No data have been reported on the effects of AT therapy administered early in severe sepsis when microcirculation is disturbed but irreversible organ damage has not yet developed...
  58. ncbi Expression and function of the endothelial protein C receptor in human neutrophils
    Daniel H Sturn
    Department of Internal Medicine, University of Innsbruck, Austria
    Blood 102:1499-505. 2003
    ..Inhibitory effects of these components of the protein C pathway on neutrophil function may play a role in the protein C-based treatment of severe sepsis...
  59. ncbi Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin
    Johannes N Hoffmann
    Department of Surgery, Ludwig Maximilian University of Munich, Munich, Germany
    Thromb Haemost 95:850-6. 2006
    ..Combined administration of the two increases bleeding risk and probably abolishes efficacy of antithrombin...
  60. ncbi Improvement in coagulation markers with antithrombin--beneficial in severe sepsis?
    Christian J Wiedermann
    Crit Care Med 32:1968-9. 2004
  61. ncbi When a single pivotal trial should not be enough-the case of drotrecogin-alfa (activated)
    Christian J Wiedermann
    Intensive Care Med 32:604; author reply 610-2. 2006
  62. ncbi Comparison of mechanisms after post-hoc analyses of the drotrecogin alfa (activated) and antithrombin III trials in severe sepsis
    Christian J Wiedermann
    Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Ann Med 36:194-203. 2004
    ..Apparently, neither of the sepsis studies meets the criteria which lie at the basis of critical assessment of the success or failure of clinical trials that could more significantly affect clinical treatment decisions...
  63. ncbi Adverse effect of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanisms
    Johannes N Hoffmann
    Department of Surgery, Chirurgische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistr 15, D 81377 Munchen, Germany
    Thromb Haemost 88:242-52. 2002
    ..These results indicate that heparin should be avoided to permit AT to modulate LPS-induced inflammatory responses...
  64. ncbi Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes
    Nicole C Kaneider
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Cell Sci 115:227-36. 2002
    ..Data indicate that antithrombin directly inhibits chemokine-stimulated migration of monocytes and lymphocytes via the effects of its heparin-binding site on cell surface syndecan-4 by activation of protein kinase C and Rho signaling...
  65. ncbi Inhibition of human neutrophil chemotaxis toward interleukin 8 with six clinical antithrombin concentrates in vitro
    Nicole C Kaneider
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Intensive Care Med 28:1447-52. 2002
    ..Antithrombin exerts direct effects on neutrophils by inhibiting chemokine-induced migration. This study examined the potency of different pharmaceutical antithrombin preparations in inhibiting neutrophil chemotaxis toward interleukin 8...
  66. ncbi Expression and function of RANK in human monocyte chemotaxis
    Birgit A Mosheimer
    University of Innsbruck, Innsbruck, Austria
    Arthritis Rheum 50:2309-16. 2004
    ..RANKL, a member of the tumor necrosis factor superfamily, is a central regulator of osteoclast recruitment and activation. Whether RANKL affects monocyte locomotion in vitro via RANK and a possible signaling pathway were investigated...
  67. ncbi Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcin
    Nicole C Kaneider
    Department of Internal Medicine, University of Innsbruck, Austria
    J Bone Miner Res 17:1872-82. 2002
    ..Binding studies showed that KC might share the binding site with CT and PCT. Data indicate that KC regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways...
  68. ncbi Syndecan-4-dependent signaling in the inhibition of endotoxin-induced endothelial adherence of neutrophils by antithrombin
    Nicole C Kaneider
    Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Thromb Haemost 90:1150-7. 2003
    ....
  69. pmc The limitations of observational studies on the treatment of severe sepsis
    Christian J Wiedermann
    Crit Care 6:546-7; author reply 548. 2002
  70. ncbi Renal impairment in cardiac surgery patients receiving hydroxyethyl starch
    Christian J Wiedermann
    Intensive Care Med 30:519-20; author reply 521. 2004
  71. ncbi The European Clinical Trials Directive revisited: the VISEAR recommendations
    Kathleen Liddell
    Faculty of Law, University of Cambridge and Cambridge Genetics Knowledge Park, UK
    Resuscitation 69:9-14. 2006
  72. ncbi Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor
    Clemens Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria
    J Immunol 176:1019-25. 2006
    ..Exposure of lymphocytes to protein C or activated protein C stimulates phosphorylation of Tyr845 of epidermal growth factor receptor, which may be relevant for cytoprotective effects of the protein C pathway...
  73. ncbi Use of the pulmonary artery catheter is not associated with worse outcome in the ICU
    Yasser Sakr
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B 1070 Brussels, Belgium
    Chest 128:2722-31. 2005
    ..In critically ill patients, the impact of pulmonary artery catheter (PAC) use on outcome is debatable. We investigated the epidemiology of PAC use in European ICUs and its relation to outcome...
  74. ncbi Treatment of intractable pruritus in drug induced cholestasis with albumin dialysis: a report of two cases
    Romuald Bellmann
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse, Innsbruck, Austria
    ASAIO J 50:387-91. 2004
    ..In conclusion, extracorporeal albumin dialysis appears to be a therapeutic option in severe drug induced cholestasis refractory to medical treatment...
  75. ncbi Expression and function of syndecan-4 in human platelets
    Nicole C Kaneider
    Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Thromb Haemost 93:1120-7. 2005
    ..From these data it is concluded that syndecan-4 may play important roles in the regulation of inflammatory effects of platelets...
  76. ncbi Src tyrosine kinase-dependent migratory effects of antithrombin in leukocytes
    Clemens Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Exp Cell Res 305:214-20. 2005
    ..Therefore, Src tyrosine kinases linked to signaling of antithrombin-binding sites on leukocytes may play an important role in modulating effects on cells function...
  77. ncbi Disturbances of electrolytes and blood chemistry in acute alcohol intoxication
    Markus Rauchenzauner
    Department of General Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
    Wien Klin Wochenschr 117:83-91. 2005
    ..A combination of elevated blood alcohol with an increase in either of these markers may be interpreted as high risk for chronic alcohol abuse in this particular group of patients...
  78. ncbi Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion
    Helene Vogelsinger
    Clinical Pharmacokinetics Unit, Laboratory of Inflammation Research, Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical School, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Antimicrob Chemother 57:1153-60. 2006
    ....
  79. ncbi Treatment of refractory cholestatic pruritus after liver transplantation with albumin dialysis
    Romuald Bellmann
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Austria
    Liver Transpl 10:107-14. 2004
    ..Our data indicate that MARS is an effective therapeutic option for patients with intractable cholestatic pruritus...
  80. ncbi Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid
    Anton Sandhofer
    Department of General Internal Medicine, University Hospital, Innsbruck, Austria
    Wien Klin Wochenschr 114:938-42. 2002
    ..The disturbances observed were hyponatremia (lowest value 108 mmol/l), hypokalemia (lowest value 1.5 mmol/l) and prerenal azotemia (highest serum urea 269 mg/dl, highest serum creatinine 5.13)...
  81. ncbi Perspectives in economic analyses of sepsis
    Christian J Wiedermann
    Wien Klin Wochenschr 114:660-2. 2002
  82. pmc The PIRO concept: P is for predisposition
    Derek C Angus
    CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:248-51. 2003
  83. ncbi Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C
    Clemens Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    J Allergy Clin Immunol 112:375-81. 2003
    ..Eosinophil infiltration is a characteristic feature of allergic inflammation. Allergic responses are associated with local activation of the coagulation pathway and accumulation of fibrin...
  84. ncbi Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study
    Stefan Kiechl
    Department of Neurology, Medical University of Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 27:1788-95. 2007
    ..Oxidized phospholipids (OxPL) circulate on apolipoprotein B-100 particles (OxPL/apoB), and primarily on Lp(a) lipoprotein (a) [Lp(a)]. The relationship of OxPL/apoB levels to future cardiovascular events is not known...
  85. ncbi Expression and function of the vascular endothelial growth factor receptor FLT-1 in human eosinophils
    Clemens Feistritzer
    Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Am J Respir Cell Mol Biol 30:729-35. 2004
    ..Thus, VEGF may play an important role in the modulation of eosinophilic inflammation...
  86. ncbi Do plasma substitutes have additional properties beyond correcting volume deficits?: Shock 25:2103-116, 2006
    Christian J Wiedermann
    Shock 27:339-42. 2007
  87. ncbi Medical research involving incapacitated adults: implications of the EU Clinical Trials Directive 2001/20/EC
    Kathleen Liddell
    Faculty of Law, University of Cambridge
    Med Law Rev 14:367-417. 2006
  88. ncbi Complications of hydroxyethyl starch in acute ischemic stroke and other brain injuries
    Christian J Wiedermann
    Pathophysiol Haemost Thromb 33:225-8; author reply 229-30. 2003
    ..The preponderance of available evidence suggests that HES solutions should be avoided in acute ischemic stroke and other brain injuries...