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Species | C J WiedermannSummaryAffiliation: Regional Hospital Country: Italy Publications
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Publications
From persistence to palliation: limiting active treatment in the ICUChristian J Wiedermann
Department of Internal Medicine, Academic Teaching Hospital, Central Hospital of Bolzano, Bolzano, Italy
Curr Opin Crit Care 18:693-9. 2012..This narrative review describes recent studies on how to improve palliative care and surrogate decision-making in ICUs and compares the results with previously published literature on this topic...- Mortality after hydroxyethyl starch 130/0.4 infusion: an updated meta-analysis of randomized trialsChristian J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
Swiss Med Wkly 142:w13656. 2012..4. As results from new trials, reporting on a large number of events became available in 2011 and 2012, an updated meta-analysis was performed... 
Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsisJordan Kountchev
Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Austria
Crit Care 9:R596-600. 2005..In the present study, we report on changes in circulating levels of D-dimer in response to administration of AT in a series of patients with acquired AT deficiency due to severe sepsis...- The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectivesCristian Pattaro
Institute of Genetic Medicine, European Academy, Bolzano, Italy
BMC Med Genet 8:29. 2007..For historical and political reasons, South Tyrol, the northern most Italian region, includes several villages of small dimensions which remained isolated over the centuries... - Immunomodulation by alpha(1)-proteinase inhibitor: lack of chemotactic effects of recombinant human alpha(1)-proteinase inhibitor from yeast on human peripheral blood granulocytesBirgit Mosheimer
Division of General Internal Medicine, Department of Medicine, Medical University of Innsbruck, A 6020, Innsbruck, Austria
Arch Immunol Ther Exp (Warsz) 55:399-403. 2007..The migratory effects of yeast-derived human recombinant alpha(1)-proteinase inhibitor on human peripheral blood neutrophils and eosinophils were therefore tested in vitro... - Digital clubbing in primary intestinal lymphangiectasia: a case reportChristian J Wiedermann
Division of Internal Medicine, Central Hospital, Bolzano, Italy
Wien Med Wochenschr 160:431-6. 2010..Digital clubbing associated with primary intestinal lymphangiectasia which may causally be related to chronic platelet excess has not been reported before... - Awareness and use of recommendations for withholding and withdrawing therapy in Austrian intensive care unitsChristian J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Bolzano BZ, Italy
Wien Med Wochenschr 161:99-102. 2011..Even though the response rate was low, Austrian intensive care medicine societies should be encouraged to better disseminate end-of-life decision guidelines among caregivers... - Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studiesChristian J Wiedermann
Division of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy
Intensive Care Med 36:1657-65. 2010..To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI)... - Enhancement of fibrinogen-triggered pro-coagulant activation of monocytes in vitro by matrix metalloproteinase-9Nicole C Kaneider
Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano BZ, Italy
Thromb J 8:2. 2010.... - Reduced watery diarrhea during pregnancy in a psoriasis patient with lymphocytic colitisC J Wiedermann
Divison of Internal Medicine 2, Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
Z Gastroenterol 46:1275-7. 2008..This clinical observation suggests that pregnancy influences the overall course of chronic watery diarrhea of autoimmune-associated microscopic colitis... 
[Scoring of disseminated intravascular coagulation (DIC) in intensive care medicine]C J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano BZ, Italy
Clin Ter 159:275-81. 2008..Early detection of DIC by application of novel scores could play a particular role in future DIC trials by defining patient populations most likely to benefit from targeted intervention in their clotting disturbance of critical illness...- Warfarin-induced bleeding complications - clinical presentation and therapeutic optionsChristian J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
Thromb Res 122:S13-8. 2008..Other advantages of PCC over FFP include smaller infusion volumes, no blood group testing and virus-inactivated blood product... - Bioethics, the Surviving Sepsis Campaign, and the industryChristian J Wiedermann
Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy
Wien Klin Wochenschr 117:442-4. 2005 - Clinical review: molecular mechanisms underlying the role of antithrombin in sepsisChristian J Wiedermann
2nd Divison of Internal Medicine, Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy
Crit Care 10:209. 2006..Final assessment of the drug's effectiveness, however, must await the availability of positive, prospective, randomized and placebo-controlled studies... - A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsisChristian J Wiedermann
Division of Internal Medicine II, Department of Medicine, Central Hospital of Bolzano, Bolzano Bozen, Italy
Blood Coagul Fibrinolysis 17:521-6. 2006..In sepsis patients with DIC, administration of antithrombin concentrate may increase overall survival. Current available evidence, however, is not suited to sufficiently inform clinical practice... - Hydroxyethyl starch--can the safety problems be ignored?Christian J Wiedermann
2nd Department of Internal Medicine, Central Hospital of Bolzano Bozen, Bolzano, Italy
Wien Klin Wochenschr 116:583-94. 2004..Limiting the dose and duration of HES therapy may be helpful in lessening the risk of undesired side effects; at present however, reliance on particular HES solutions does not appear sufficient to ensure safety... - Bacillus species infective arthritis after knee arthroscopyChristian J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy
Surg Infect (Larchmt) 11:555-8. 2010..Bacillus species infection of the joints is a very rare occurrence, with sporadic reports in the medical literature... - Hyperoncotic colloids and acute kidney injury: a meta-analysis of randomized trialsChristian J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy
Crit Care 14:R191. 2010..It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear... - Fatal cardiac arrest in an adult patient with euthyroid anti-SSA/Ro-positive connective tissue disease: a case reportMichele Adami
Department of Internal Medicine, Central Hospital of Bolzano, , IT 39100 Bolzano, Italy
Int Arch Med 2:15. 2009..CONCLUSION: This case might indicate that, although the adult heart conduction system may be relatively resistant to the development of anti-Ro-associated complete heart block, cardiac arrest may develop and even be fatal... - Mesenteric panniculitis presenting with acute non-occlusive colonic ischemiaFlorian Amor
Division of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, Bolzano 39100, Italy
Int Arch Med 4:22. 2011..abstract:.. - [Volume replacement therapy options for critically ill patients]C J Wiedermann
Abteilung fur Innere Medizin, Zentralkrankenhaus Bozen, Italien
Med Klin Intensivmed Notfmed 106:53-64; quiz 65-6. 2011..Artificial colloids (hydroxyethyl starch) are cheaper than the natural colloid albumin but the safety profile is less favorable... - [Endogenous anticoagulant therapy for sepsis. Success and failure]C J Wiedermann
Abteilung fur Innere Medizin, Zentralkrankenhaus und Akademisches Lehrkrankenhaus der Medizinischen Universität Innsbruck in Bozen, L Böhler Strasse 5, 39100 Bozen
Internist (Berl) 48:537-42, 544. 2007.... - Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck StudyC J Wiedermann
Department of Internal Medicine, Medical Faculty, University of Innsbruck, Austria
J Am Coll Cardiol 34:1975-81. 1999..Focus of the current study was on the significance of bacterial endotoxin, which shows a variety of pro-atherogenic properties and may occur at high concentration in the circulation of infected subjects... - Cell-surface heparan sulfate proteoglycan-mediated regulation of human neutrophil migration by the serpin antithrombin IIIS Dunzendorfer
Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria, and Aventis Behring GmbH Research, Marburg, Germany
Blood 97:1079-85. 2001..Under physiological conditions, AT III may prevent neutrophils from premature activation. Moreover, the systemic administration of AT III concentrate could have beneficial effects in combating systemic inflammation... - Syndecan-4-dependent migration of human eosinophilsC Feistritzer
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
Clin Exp Allergy 34:696-703. 2004..Ligation of syndecan-4 with anti-thrombin III induces eosinophil migration and deactivates motility toward chemokines. These observations suggest that syndecan-4-dependent signalling may control eosinophil locomotion... - Plasma-induced endothelial activation associated with incident atherosclerosis: prospective results from the Bruneck StudyP Schratzberger
Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Austria
J Cardiovasc Risk 7:285-91. 2000..Whether systemic inflammation is an epiphenomenon of atherosclerosis or whether it is part of the atherosclerosis causal pathway requires further study... - Secretoneurin and neurogenic inflammationC J Wiedermann
Laboratory of Intensive Care Medicine, Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Zhongguo Yao Li Xue Bao 20:789-94. 1999..Review of evidence that the 33-amino-acid polypeptide secretoneurin, which is generated by proteolytic cleavage of secretogranin II, plays a role in neurogenic inflammation... - Induction of arachidonic acid metabolite release by human fibroblasts in proliferative vitreoretinopathyC M Kahler
Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Austria
Eur J Pharmacol 341:111-7. 1998.... - Induction of apoptosis and inhibition of migration of inflammatory and vascular wall cells by cerivastatinN C Kaneider
Division of General Internal Medicine, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
Atherosclerosis 158:23-33. 2001..In addition to its lipid-lowering effects, pharmacological properties of cerivastatin may include modulatory actions in leukocytes and mesenchymal cells... - Protein kinase C-dependent effects on leukocyte migration of thalidomideC Meierhofer
Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
J Infect Dis 180:216-9. 1999..Results suggest that effects of thalidomide in chronic inflammation may be related to actions on leukocyte functions... - Cutting edge: peripheral neuropeptides attract immature and arrest mature blood-derived dendritic cellsS Dunzendorfer
Divisions of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
J Immunol 166:2167-72. 2001..It seems that one function of sensory nerves is to fasten DC at sites of inflammation... - Hypersensitivity reactions associated with recombinant tissue-type plasminogen activator and urokinaseC Pechlaner
Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria
Blood Coagul Fibrinolysis 12:491-4. 2001..Steroids do not prevent, but histamine receptor blockers seem to be an effective treatment of this unusual complication of thrombolytic therapy... - Influence of neuropeptides on neutrophil adhesion and transmigration through a lung fibroblast barrier in vitroC M Kahler
Department of Internal Medicine, Division of General Internal Medicine Pulmonology and ICU, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
Exp Lung Res 27:25-46. 2001..In conclusion, SP in concert with proinflammatory cytokines may regulate neutrophil interstitial accumulation and their traffic to the alveolar space in lung inflammation... - The role of immune activation in endotoxin-induced atherogenesisC J Wiedermann
Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
J Endotoxin Res 7:322-6. 2001..The study provides epidemiological evidence that the atherogenic potential of endotoxemia is affected by concomitant immune activation... - Incidence and risk of potential adverse drug interactions in the emergency roomD Heininger Rothbucher
Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Resuscitation 49:283-8. 2001..Safeguards need to be introduced to prevent patients from receiving medications in the emergency departments that have the potential to cause adverse interactions... - Secretoneurin: a functional neuropeptide in health and diseaseC J Wiedermann
Department of Internal Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
Peptides 21:1289-98. 2000..With an array of actions as diverse as that seen with other sensory neuropeptides, there is scope for numerous studies and therapeutic possibilities... - Functional expression of chemokine receptor 2 by normal human eosinophilsS Dunzendorfer
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Austria
J Allergy Clin Immunol 108:581-7. 2001..In vivo administration of neutralizing anti-monocyte chemoattractant protein 1 (MCP-1) antibodies can block accumulation of eosinophils in the lungs of antigen-challenged animals... - Plasma levels of procalcitonin and interleukin-6 in acute myocardial infarctionT Buratti
Department of Internal Medicine, University of Innsbruck, Austria
Inflammation 25:97-100. 2001..This observation may support the role of procalcitonin measurements in the differential diagnosis of infectious and cardiovascular complications after major surgery... - The inhibition of oxygen radical release from human neutrophils by resting platelets is reversed by administration of acetylsalicylic acid or clopidogrelC M Reinisch
Medical Intensive Care Unit, Division of General Internal Medicine, Department of Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Free Radic Res 34:461-6. 2001..Results suggest that the protective role of resting platelets in controlling oxygen radical release from neutrophils in the absence of platelet activation may be impaired by antiplatelet therapy... - Two cases of foodborne botulism with home-preserved asparagusP Zanon
Department of Anesthesiology and Critical Care Medicine II, Central Hospital of Bolzano, Italy
Anasthesiol Intensivmed Notfallmed Schmerzther 41:156-9. 2006..Despite the fact that amount of toxin ingested, time-to-symptom development, and time-to-recovery markedly differed in the two patients, their maximal disease severity was similar... - Patient risk factors and adverse drug interactions in the treatment of acute gouty arthritis in the elderly: a case reportBernhard Zagler
Division of Internal Medicine, Department of Medicine, Central Hospital of Bolzano, L Böhler Street 5, I 39100 Bolzano BZ, Italy
Cases J 2:6602. 2009..Gastrointestinal toxicity of colchicine is dose-dependent and can be aggravated by drug-drug and drug-patient interactions... - [Minimizing perioperative risk - an interdisciplinary effort]Matthias Bock
Dienst für Anästhesie und Intensivmedizin, Zentralkrankenhaus Bozen, Bozen, Italien
Wien Med Wochenschr 158:590-4. 2008..In this review, we describe the major perioperative cardiac, pulmonary and vascular risks for physicians involved in the treatment of surgical patients... - Nosocomial diarrhoea in adult medical patients: the role of Clostridium difficile in a North Italian acute care teaching hospitalS Sansone
Department of Medicine, Central Hospital of Bolzano, Italy
J Prev Med Hyg 50:117-20. 2009..Health care facilities are requested to establish rates of nosocomially acquired CDAD (N-CDAD) to understand the impact of control or prevention measures, and the burden of N-CDAD on health care resources... - Elimination of levofloxacin in critically ill patients with renal failure: influence of continuous veno-venous hemofiltrationR Bellmann
Department of Internal Medicine, University of Innsbruck, Austria
Int J Clin Pharmacol Ther 40:142-9. 2002..Pharmacokinetic data on levofloxacin in critically ill patients are sparse and conflicting. Aim of the study was to assess the clearance of levofloxacin in critically ill patients treated with continuous veno-venous hemofiltration (CVVH)... - Baseline severity of sepsis in subjects of the prowess and the Kybersept clinical trials on endogenous anticoagulantsChristian J Wiedermann
Department of Internal Medicine, Central Hospital of Bolzano, Bolzano (BZ, Italy
Shock 25:657-8. 2006 - Determination of amphotericin B, liposomal amphotericin B, and amphotericin B colloidal dispersion in plasma by high-performance liquid chromatographyP Egger
Department of Medicine, Innsbruck University Hospital, Austria
J Chromatogr B Biomed Sci Appl 760:307-13. 2001..No interference from other drugs (typical broad medication for intensive-care patients) or common plasma components was detected in >400 samples analyzed... - High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safetyChristian J Wiedermann
Department of Medicine, Central Hospital of the Province of Bolzano, Bolzano, Italy
Crit Care Med 34:285-92. 2006..CONCLUSIONS: Treatment with high-dose antithrombin III may increase survival time up to 90 days in patients with severe sepsis and high risk of death. This benefit may even be stronger when concomitant heparin is avoided... - Theoretical basis for the activity of thalidomideC Meierhofer
Laboratory of Intensive Care Medicine, Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
BioDrugs 15:681-703. 2001..However, despite the promising findings of thalidomide at the molecular level, namely its anti-TNFalpha properties and its intercalation with DNA, and activity in clinical trials, there is still a great need for more intensive research... - Syndecan-4 as antithrombin receptor of human neutrophilsN C Kaneider
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Biochem Biophys Res Commun 287:42-6. 2001..In the presence of pentasaccharide, antithrombin lost its activity on the cells. Data suggest that antithrombin regulates neutrophil migration via effects of its heparin-binding site on cell surface syndecan-4... - Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population studyS Kiechl
Departments of Neurology, University Clinic Innsbruck, Innsbruck, Austria
Circulation 103:1064-70. 2001..CONCLUSIONS: The present study provides solid evidence for a role of common chronic infections in human atherogenesis. Induction of systemic inflammation and autoimmunity may be potential pathophysiological links... - Thromboembolism in pulmonary artery sarcomaMohsen Farsad
Department of Nuclear Medicine, Central Hospital of Bolzano, Bolzano, Italy
Clin Nucl Med 34:239-40. 2009.... - Comparison of mechanisms after post-hoc analyses of the drotrecogin alfa (activated) and antithrombin III trials in severe sepsisChristian J Wiedermann
Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Ann Med 36:194-203. 2004..Apparently, neither of the sepsis studies meets the criteria which lie at the basis of critical assessment of the success or failure of clinical trials that could more significantly affect clinical treatment decisions... - Effects of anticoagulant strategies on activation of inflammation and coagulationClemens Feistritzer
Medical University of Innsbruck, Department of Internal Medicine, Innsbruck Tyrol, Austria
Expert Opin Biol Ther 7:855-70. 2007.... - Expression and function of the endothelial protein C receptor in human neutrophilsDaniel H Sturn
Department of Internal Medicine, University of Innsbruck, Austria
Blood 102:1499-505. 2003..Inhibitory effects of these components of the protein C pathway on neutrophil function may play a role in the protein C-based treatment of severe sepsis... - Early administration of high-dose antithrombin in severe sepsis: single center results from the KyberSept-trialAlain Eid
Division of Pulmonary and Critical Care, CO Springs Memorial Hospital, CO Springs, Colorado, USA
Anesth Analg 107:1633-8. 2008..No data have been reported on the effects of AT therapy administered early in severe sepsis when microcirculation is disturbed but irreversible organ damage has not yet developed... - Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparinJohannes N Hoffmann
Department of Surgery, Ludwig-Maximilian University of Munich, Munich, Germany
Thromb Haemost 95:850-6. 2006..Combined administration of the two increases bleeding risk and probably abolishes efficacy of antithrombin... - Improvement in coagulation markers with antithrombin--beneficial in severe sepsis?Christian J Wiedermann
Crit Care Med 32:1968-9. 2004 - When a single pivotal trial should not be enough-the case of drotrecogin-alfa (activated)Christian J Wiedermann
Intensive Care Med 32:604; author reply 610-2. 2006 - Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcinNicole C Kaneider
Department of Internal Medicine, University of Innsbruck, Austria
J Bone Miner Res 17:1872-82. 2002..Binding studies showed that KC might share the binding site with CT and PCT. Data indicate that KC regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways... - Expression and function of RANK in human monocyte chemotaxisBirgit A Mosheimer
University of Innsbruck, Innsbruck, Austria
Arthritis Rheum 50:2309-16. 2004..RANKL, a member of the tumor necrosis factor superfamily, is a central regulator of osteoclast recruitment and activation. Whether RANKL affects monocyte locomotion in vitro via RANK and a possible signaling pathway were investigated... - Perspectives in economic analyses of sepsisChristian J Wiedermann
Wien Klin Wochenschr 114:660-2. 2002 - Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamidAnton Sandhofer
Department of General Internal Medicine, University Hospital, Innsbruck, Austria
Wien Klin Wochenschr 114:938-42. 2002..This is especially true for elderly patients... - The limitations of observational studies on the treatment of severe sepsisChristian J Wiedermann
Crit Care 6:546-7; author reply 548. 2002 - Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytesNicole C Kaneider
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
J Cell Sci 115:227-36. 2002..Data indicate that antithrombin directly inhibits chemokine-stimulated migration of monocytes and lymphocytes via the effects of its heparin-binding site on cell surface syndecan-4 by activation of protein kinase C and Rho signaling... - Adverse effect of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanismsJohannes N Hoffmann
Department of Surgery, Chirurgische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistr 15, D 81377 Munchen, Germany
Thromb Haemost 88:242-52. 2002..These results indicate that heparin should be avoided to permit AT to modulate LPS-induced inflammatory responses... - Inhibition of human neutrophil chemotaxis toward interleukin 8 with six clinical antithrombin concentrates in vitroNicole C Kaneider
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Intensive Care Med 28:1447-52. 2002.... - Disturbances of electrolytes and blood chemistry in acute alcohol intoxicationMarkus Rauchenzauner
Department of General Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
Wien Klin Wochenschr 117:83-91. 2005..A combination of elevated blood alcohol with an increase in either of these markers may be interpreted as high risk for chronic alcohol abuse in this particular group of patients... - The PIRO concept: P is for predispositionDerek C Angus
CRISMA Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 7:248-51. 2003 - Expression and function of syndecan-4 in human plateletsNicole C Kaneider
Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Thromb Haemost 93:1120-7. 2005..From these data it is concluded that syndecan-4 may play important roles in the regulation of inflammatory effects of platelets... - Complications of hydroxyethyl starch in acute ischemic stroke and other brain injuriesChristian J Wiedermann
Pathophysiol Haemost Thromb 33:225-8; author reply 229-30. 2003..The preponderance of available evidence suggests that HES solutions should be avoided in acute ischemic stroke and other brain injuries... - Use of the pulmonary artery catheter is not associated with worse outcome in the ICUYasser Sakr
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B-1070 Brussels, Belgium
Chest 128:2722-31. 2005..Survival to 60 days was similar between the two matched groups (log rank = 0.02; p = 0.894). CONCLUSIONS: This observational study suggests that PAC use is not associated with increased mortality in this heterogeneous population... - Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptorClemens Feistritzer
Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria
J Immunol 176:1019-25. 2006..Exposure of lymphocytes to protein C or activated protein C stimulates phosphorylation of Tyr845 of epidermal growth factor receptor, which may be relevant for cytoprotective effects of the protein C pathway... - The European Clinical Trials Directive revisited: the VISEAR recommendationsKathleen Liddell
Faculty of Law, University of Cambridge and Cambridge Genetics Knowledge Park, UK
Resuscitation 69:9-14. 2006 - Syndecan-4-dependent signaling in the inhibition of endotoxin-induced endothelial adherence of neutrophils by antithrombinNicole C Kaneider
Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Thromb Haemost 90:1150-7. 2003.... - Treatment of intractable pruritus in drug induced cholestasis with albumin dialysis: a report of two casesRomuald Bellmann
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse, Innsbruck, Austria
ASAIO J 50:387-91. 2004..In conclusion, extracorporeal albumin dialysis appears to be a therapeutic option in severe drug induced cholestasis refractory to medical treatment... - Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersionHelene Vogelsinger
Clinical Pharmacokinetics Unit, Laboratory of Inflammation Research, Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical School, Anichstrasse 35, A-6020 Innsbruck, Austria
J Antimicrob Chemother 57:1153-60. 2006..CONCLUSIONS: The choice of lipid formulation may influence amphotericin B penetration into the lung... - Medical research involving incapacitated adults: implications of the EU Clinical Trials Directive 2001/20/ECKathleen Liddell
Faculty of Law, University of Cambridge
Med Law Rev 14:367-417. 2006 - Do plasma substitutes have additional properties beyond correcting volume deficits?: Shock 25:2103-116, 2006Christian J Wiedermann
Shock 27:339-42. 2007 - Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck studyStefan Kiechl
Department of Neurology, Medical University of Innsbruck, Austria
Arterioscler Thromb Vasc Biol 27:1788-95. 2007..Oxidized phospholipids (OxPL) circulate on apolipoprotein B-100 particles (OxPL/apoB), and primarily on Lp(a) lipoprotein (a) [Lp(a)]. The relationship of OxPL/apoB levels to future cardiovascular events is not known... - Treatment of refractory cholestatic pruritus after liver transplantation with albumin dialysisRomuald Bellmann
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Austria
Liver Transpl 10:107-14. 2004..Our data indicate that MARS is an effective therapeutic option for patients with intractable cholestatic pruritus... - Renal impairment in cardiac surgery patients receiving hydroxyethyl starchChristian J Wiedermann
Intensive Care Med 30:519-20; author reply 521. 2004 - Expression and function of the vascular endothelial growth factor receptor FLT-1 in human eosinophilsClemens Feistritzer
Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Am J Respir Cell Mol Biol 30:729-35. 2004..Thus, VEGF may play an important role in the modulation of eosinophilic inflammation... - Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein CClemens Feistritzer
Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
J Allergy Clin Immunol 112:375-81. 2003..Eosinophil infiltration is a characteristic feature of allergic inflammation. Allergic responses are associated with local activation of the coagulation pathway and accumulation of fibrin... - Src tyrosine kinase-dependent migratory effects of antithrombin in leukocytesClemens Feistritzer
Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
Exp Cell Res 305:214-20. 2005..Therefore, Src tyrosine kinases linked to signaling of antithrombin-binding sites on leukocytes may play an important role in modulating effects on cells function...