Aldo Venuti

Summary

Affiliation: Regina Elena Cancer Institute
Country: Italy

Publications

  1. pmc Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma
    Francesca Paolini
    Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 30:108. 2011
  2. pmc HPV detection methods in head and neck cancer
    Aldo Venuti
    Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
    Head Neck Pathol 6:S63-74. 2012
  3. pmc Papillomavirus E5: the smallest oncoprotein with many functions
    Aldo Venuti
    Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
    Mol Cancer 10:140. 2011
  4. pmc HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future
    Luciano Mariani
    Dept Gynaecologic Oncology, National Cancer Institute Regina Elena of Rome, Italy
    J Transl Med 8:105. 2010
  5. ncbi request reprint Endothelin receptor blockade inhibits the growth of human papillomavirus-associated cervical carcinoma
    Aldo Venuti
    Laboratory of Virology, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Clin Sci (Lond) 103:310S-313S. 2002
  6. ncbi request reprint Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy
    A Venuti
    Laboratories of Virology, Regina Elena Cancer Institue, 00158 Rome, Italy
    FASEB J 14:2277-83. 2000
  7. ncbi request reprint Presence of HPV in head and neck tumours: high prevalence in tonsillar localization
    A Venuti
    Laboratory of Virology, Regina Elena Cancer Institute, San Carlo, IDI IRCCS, Rome, Italy
    J Exp Clin Cancer Res 23:561-6. 2004
  8. pmc Progress and challenges in the vaccine-based treatment of head and neck cancers
    Aldo Venuti
    Laboratory of Virology, Regina Elena Cancer Institute, Via Messi d Oro, 156 00158 Rome, Italy
    J Exp Clin Cancer Res 28:69. 2009
  9. doi request reprint An E7-based therapeutic vaccine protects mice against HPV16 associated cancer
    Aldo Venuti
    Regina Elena Cancer Institute, Laboratory of Virology, Via delle Messi d Oro 156, 00158 Rome, Italy
    Vaccine 27:3395-7. 2009
  10. ncbi request reprint Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma
    Laura Rosanò
    Laboratories of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, 00158 Rome, Italy
    Cancer Res 63:2447-53. 2003

Collaborators

Detail Information

Publications40

  1. pmc Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma
    Francesca Paolini
    Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 30:108. 2011
    ..Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients...
  2. pmc HPV detection methods in head and neck cancer
    Aldo Venuti
    Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
    Head Neck Pathol 6:S63-74. 2012
    ..In this way, it is expected to be possible to correlate the appropriate transcriptome-based diagnosis to the patients' specific cancer risk...
  3. pmc Papillomavirus E5: the smallest oncoprotein with many functions
    Aldo Venuti
    Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
    Mol Cancer 10:140. 2011
    ..This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent...
  4. pmc HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future
    Luciano Mariani
    Dept Gynaecologic Oncology, National Cancer Institute Regina Elena of Rome, Italy
    J Transl Med 8:105. 2010
    ..Therefore, long term immunization and cross-protection of HPV vaccines will be discussed in light of new approaches for the future...
  5. ncbi request reprint Endothelin receptor blockade inhibits the growth of human papillomavirus-associated cervical carcinoma
    Aldo Venuti
    Laboratory of Virology, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Clin Sci (Lond) 103:310S-313S. 2002
    ..In conclusion, an ET-1 autocrine loop is involved in tumour cell proliferation via ET(A)R, and ABT-627 is effective in controlling proliferation of cervical carcinoma cells...
  6. ncbi request reprint Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy
    A Venuti
    Laboratories of Virology, Regina Elena Cancer Institue, 00158 Rome, Italy
    FASEB J 14:2277-83. 2000
    ..These results demonstrate that ET-1 participates in the progression of neoplastic growth in HPV-associated carcinoma, in which ETAR are increased and could be targeted for antitumor therapy...
  7. ncbi request reprint Presence of HPV in head and neck tumours: high prevalence in tonsillar localization
    A Venuti
    Laboratory of Virology, Regina Elena Cancer Institute, San Carlo, IDI IRCCS, Rome, Italy
    J Exp Clin Cancer Res 23:561-6. 2004
    ..The results suggest that HPV16 is actively involved in the genesis of a subset of head and neck cancers and that the tonsillar localization may be considered a hot spot for viral transformation...
  8. pmc Progress and challenges in the vaccine-based treatment of head and neck cancers
    Aldo Venuti
    Laboratory of Virology, Regina Elena Cancer Institute, Via Messi d Oro, 156 00158 Rome, Italy
    J Exp Clin Cancer Res 28:69. 2009
    ..This article reviews what has to be rather what has been done in the field for the development of future vaccines in HN tumours...
  9. doi request reprint An E7-based therapeutic vaccine protects mice against HPV16 associated cancer
    Aldo Venuti
    Regina Elena Cancer Institute, Laboratory of Virology, Via delle Messi d Oro 156, 00158 Rome, Italy
    Vaccine 27:3395-7. 2009
    ..Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines...
  10. ncbi request reprint Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma
    Laura Rosanò
    Laboratories of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, 00158 Rome, Italy
    Cancer Res 63:2447-53. 2003
    ..Interruption of ET(A)R signaling therefore, represents, a promising therapeutic strategy in ovarian carcinoma...
  11. ncbi request reprint Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade
    Anna Bagnato
    Laboratoryies of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy
    Cancer Res 62:6381-4. 2002
    ..These results demonstrate that by inhibiting cell proliferation and angiogenesis, this small molecule may help to control cervical cancer by either monotherapy or combination therapy...
  12. doi request reprint Both mucosal and cutaneous papillomaviruses are in the oral cavity but only alpha genus seems to be associated with cancer
    Francesca Paolini
    Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
    J Clin Virol 56:72-6. 2013
    ..The majority of published studies on HPV prevalence in these tumors concentrated on identifying high-risk mucosal types...
  13. ncbi request reprint ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitro
    Debora Salani
    Laboratory of Molecular Pathology, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Clin Sci (Lond) 103:318S-321S. 2002
    ....
  14. ncbi request reprint Plant-derived human papillomavirus 16 E7 oncoprotein induces immune response and specific tumor protection
    Rosella Franconi
    Ente per le Nuove Tecnologie, Energia e Ambiente, UTS Biotech, Sezione Genetica e Genomica Vegetale, CR Casaccia, Rome, Italy
    Cancer Res 62:3654-8. 2002
    ..Our data support the possibility of producing a cost-effective anticancer vaccine in plant with intrinsic adjuvant-like properties...
  15. ncbi request reprint Persistence of HPV after radio-chemotherapy in locally advanced cervical cancer
    Gianna Badaracco
    Division of Virology, Regina Elena Cancer Institute, Rome, Italy
    Oncol Rep 23:1093-9. 2010
    ..03) tool to assess the efficacy of the treatment...
  16. ncbi request reprint Targeting endothelin receptor type A in human cervical carcinoma cells
    Alessia Cirilli
    Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
    J Cardiovasc Pharmacol 44:S72-5. 2004
    ..In conclusion, targeting the endothelin-A receptor, but not the endothelin-B receptor, may be a valid tool in the therapy of cervical carcinoma...
  17. ncbi request reprint Physical status of HPV types 16 and 18 in topographically different areas of genital tumours and in paired tumour-free mucosa
    Gianna Badaracco
    Laboratory of Virology, Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy
    Int J Oncol 27:161-7. 2005
    ....
  18. ncbi request reprint DNA vaccines against HPV-16 E7-expressing tumour cells
    Federico De Marco
    Laboratory of Virology, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158, Rome, Italy
    Anticancer Res 23:1449-54. 2003
    ..The E7 protein from "high risk" Human Papillomavirus (HPV) is constitutively expressed in cervical cancer and represents a target for immunotherapy...
  19. ncbi request reprint Human papillomavirus in head and neck carcinomas: prevalence, physical status and relationship with clinical/pathological parameters
    G Badaracco
    Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
    Anticancer Res 20:1301-5. 2000
    ..The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer...
  20. ncbi request reprint Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth
    A Bagnato
    Laboratory of Molecular Pathology, Regina Elena Cancer Institute, Rome, Italy
    Cancer Res 59:720-7. 1999
    ..In conclusion, the present data demonstrate a novel mechanism in the growth control of ovarian carcinoma in vivo mediated by the ET-1 autocrine loop that selectively occurs via the ET(A)R...
  21. ncbi request reprint The E5 oncoprotein of human papillomavirus type 16 enhances endothelin-1-induced keratinocyte growth
    A Venuti
    Laboratory of Virology, Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Institute for Cancer Research, CRS, Via delle Messi d Oro 156, Rome, 00158, Italy
    Virology 248:1-5. 1998
    ..In conclusion, our data demonstrate that E5 enhances ligand signaling in keratinocytes outside the EGF pathway by the amplification of the proliferative effect of ET-1/ETA receptor signaling...
  22. ncbi request reprint Human papillomavirus type 5 in primary keratinocytes from psoriatic skin
    Paola Simeone
    Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
    Exp Dermatol 14:824-9. 2005
    ....
  23. ncbi request reprint Mutants of plant genes for developing cancer vaccines
    Silvia Massa
    ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, CR Casaccia, UT BIORAD FARM, Rome, Italy
    Hum Vaccin 7:147-55. 2011
    ..These data demonstrate that mutant plant genes hold promise to improve the poor immunogenicity of tumor-associated cancer antigens and could contribute to the evolution of new cancer immunotherapy...
  24. ncbi request reprint Molecular analyses and prognostic relevance of HPV in head and neck tumours
    Gianna Badaracco
    Laboratory of Virology, Regina Elena Cancer Institute, 00158 Rome, Italy
    Oncol Rep 17:931-9. 2007
    ....
  25. ncbi request reprint Human papillomavirus therapeutic vaccines in head and neck tumors
    Gianna Badaracco
    Regina Elena Cancer Institute, Laboratory of Virology, Rome, Italy
    Expert Rev Anticancer Ther 7:753-66. 2007
    ..This article reviews what has been achieved and what remains to be done in the field for the development of future viral vaccines in head and neck tumors...
  26. doi request reprint Predictors of human papilloma virus (HPV) infection in Italian women
    M C Cercato
    Department of Epidemiology, Regina Elena National Cancer Institute, Rome, Italy
    J Med Virol 82:1921-7. 2010
    ..These findings provide a contribution in the knowledge of an adult population defining a "high-risk" sexual behavioral profile and could be helpful to target prophylactic strategies in older woman...
  27. ncbi request reprint HPV5b variant in a neoplastic lesion of an Italian patient affected by epidermodysplasia verruciformis
    L M Muscardin
    Laboratory of Cutaneous Histopathology, Institute of Dermatology S Maria and San Gallicano, Via Chianesi, 53, 00144 Rome, Italy
    Eur J Dermatol 11:572-5. 2001
    ....
  28. pmc Identification of Episomal Human Papillomavirus and Other DNA Viruses in Cytological Anal Samples of HIV-Uninfected Men Who Have Sex with Men
    Maria Gabriella Donà
    Sexually Transmitted Infection STI Unit, San Gallicano Dermatological Institute, Rome, Italy
    PLoS ONE 8:e72228. 2013
    ..Other DNA viruses were detected in the anal samples of these individuals, although the significance of this occurrence needs to be assessed. ..
  29. ncbi request reprint UVB irradiation down-regulates HPV-16 RNA expression: implications for malignant progression of transformed cells
    Federico De Marco
    Laboratory of Virology, Regina Elena Institute for Cancer Research, V delle Messi d Oro, 156 00156 Rome, Italy
    Virus Res 130:249-59. 2007
    ..We propose that reported suppression of viral oncogenes, restoring the cell control on growth and repair mechanisms, allows the damage repair, ultimately resulting in a surviving response...
  30. ncbi request reprint HPV16 and HPV18 in genital tumors: Significantly different levels of viral integration and correlation to tumor invasiveness
    Gianna Badaracco
    Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
    J Med Virol 67:574-82. 2002
    ..In conclusion, virus typing in conjunction with the evaluation of the integration status may provide a better prognostic evaluation together with an improved diagnosis...
  31. pmc Role of endothelin-1 in neovascularization of ovarian carcinoma
    D Salani
    Laboratories of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy
    Am J Pathol 157:1537-47. 2000
    ..These findings indicate that ET-1 could modulate tumor angiogenesis, acting directly and in part through VEGF...
  32. pmc The autonomous growth of human papillomavirus type 16-immortalized keratinocytes is related to the endothelin-1 autocrine loop
    A Venuti
    Laboratory of Virology, Regina Elena Institute for Cancer Research, Rome, Italy
    J Virol 71:6898-904. 1997
    ..These data suggest a new mechanism in the growth control of HPV-transformed cells mediated by the upregulation of ET-1 autocrine loop...
  33. ncbi request reprint Bovine papillomavirus type 4 in oesophageal papillomas of cattle from the south of Italy
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Infectious Diseases Division, Faculty of Veterinary Medicine, Naples University Federico II, Rome, Italy
    J Comp Pathol 128:203-6. 2003
    ..Nucleotide sequencing of the PCR amplicons confirmed the presence of BPV-4 in the papillomas. This is the first report of such infections in a European country other than Britain...
  34. pmc A Chlamydomonas-derived Human Papillomavirus 16 E7 vaccine induces specific tumor protection
    Olivia C Demurtas
    ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Casaccia Research Center, Rome, Italy
    PLoS ONE 8:e61473. 2013
    ....
  35. pmc Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients
    Francesca Paolini
    Laboratory of Virology, Regina Elena Cancer Institute Via delle Messi d Oro 156 00158 Rome, Italy
    Virol J 8:103. 2011
    ..The main objective of the study was the detection of MCPyV and viral expression in clinical samples of Italian patients who were diagnosed MCC...
  36. ncbi request reprint HPV 16 E7 antibody levels in cervical cancer patients: before and after treatment
    A Di Lonardo
    Laboratory of Virology, Regina Elena Institute for Cancer Research, Rome, Italy
    J Med Virol 54:192-5. 1998
    ..These results confirm the usefulness of studying anti-HPV16 E7 antibody profile in cervical cancer patients and suggest that the serum response correlates with tumour burden...
  37. ncbi request reprint Egg yolk antibodies against the E7 oncogenic protein of human papillomavirus type 16
    A D Di Lonardo
    Laboratory of Virology, Regina Elena Institute for Cancer Research, Rome, Italy
    Arch Virol 146:117-25. 2001
    ....
  38. ncbi request reprint Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary medicine FEDERICO II Naples University, Via F Delpino, 1 80137 Naples, Italy
    J Gen Virol 84:2921-6. 2003
    ..Taken together, these data on naturally occurring bovine bladder tumours corroborate the hypothesis of their virus origin...
  39. ncbi request reprint Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinary bladder in cattle
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, University of Naples Federico II, Via F Delpino, 1, 80137, Naples, Italy
    Cancer Lett 250:82-91. 2007
    ..Furthermore, the expression of the two viral oncoproteins confirm that the virus may have a causative role in the neoplastic process...
  40. ncbi request reprint Anti-cancer activity of plant-produced HPV16 E7 vaccine
    Silvia Massa
    ENEA, Italian National Agency for New Technologies, Energy and the Environment, BAS BIOTEC GEN, C R Casaccia, Via Anguillarese 301, 00123 Rome, Italy
    Vaccine 25:3018-21. 2007
    ..Furthermore, when administered after challenge, these plant-produced antigens prevented tumor development...