Research Topics
Species | Aldo VenutiSummaryAffiliation: Regina Elena Cancer Institute Country: Italy Publications
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Detail Information
Publications
HPV detection methods in head and neck cancerAldo Venuti
Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
Head Neck Pathol 6:S63-74. 2012..In this way, it is expected to be possible to correlate the appropriate transcriptome-based diagnosis to the patients' specific cancer risk...- Papillomavirus E5: the smallest oncoprotein with many functionsAldo Venuti
Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
Mol Cancer 10:140. 2011..This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent... - HPV vaccine: an overview of immune response, clinical protection, and new approaches for the futureLuciano Mariani
Dept Gynaecologic Oncology, National Cancer Institute Regina Elena of Rome, Italy
J Transl Med 8:105. 2010..Therefore, long term immunization and cross-protection of HPV vaccines will be discussed in light of new approaches for the future... 
Presence of HPV in head and neck tumours: high prevalence in tonsillar localizationA Venuti
Laboratory of Virology, Regina Elena Cancer Institute, San Carlo, IDI IRCCS, Rome, Italy
J Exp Clin Cancer Res 23:561-6. 2004..The results suggest that HPV16 is actively involved in the genesis of a subset of head and neck cancers and that the tonsillar localization may be considered a hot spot for viral transformation...
An E7-based therapeutic vaccine protects mice against HPV16 associated cancerAldo Venuti
Regina Elena Cancer Institute, Laboratory of Virology, Via delle Messi d Oro 156, 00158 Rome, Italy
Vaccine 27:3395-7. 2009..Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines...- Progress and challenges in the vaccine-based treatment of head and neck cancersAldo Venuti
Laboratory of Virology, Regina Elena Cancer Institute, Via Messi d Oro, 156 00158 Rome, Italy
J Exp Clin Cancer Res 28:69. 2009..This article reviews what has to be rather what has been done in the field for the development of future vaccines in HN tumours... - Endothelin receptor blockade inhibits the growth of human papillomavirus-associated cervical carcinomaAldo Venuti
Laboratory of Virology, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
Clin Sci (Lond) 103:310S-313S. 2002..In conclusion, an ET-1 autocrine loop is involved in tumour cell proliferation via ET(A)R, and ABT-627 is effective in controlling proliferation of cervical carcinoma cells... - Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapyA Venuti
Laboratories of Virology, Regina Elena Cancer Institue, 00158 Rome, Italy
FASEB J 14:2277-83. 2000..These results demonstrate that ET-1 participates in the progression of neoplastic growth in HPV-associated carcinoma, in which ETAR are increased and could be targeted for antitumor therapy... - Therapeutic targeting of the endothelin a receptor in human ovarian carcinomaLaura Rosanò
Laboratories of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, 00158 Rome, Italy
Cancer Res 63:2447-53. 2003..Interruption of ET(A)R signaling therefore, represents, a promising therapeutic strategy in ovarian carcinoma... - Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockadeAnna Bagnato
Laboratoryies of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy
Cancer Res 62:6381-4. 2002..These results demonstrate that by inhibiting cell proliferation and angiogenesis, this small molecule may help to control cervical cancer by either monotherapy or combination therapy... - ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitroDebora Salani
Laboratory of Molecular Pathology, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy
Clin Sci (Lond) 103:318S-321S. 2002.... - DNA vaccines against HPV-16 E7-expressing tumour cellsFederico De Marco
Laboratory of Virology, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158, Rome, Italy
Anticancer Res 23:1449-54. 2003..CONCLUSION: Engineering the intracellular pathway for antigen presentation is able to produce a valid therapeutic response even against tumours with down-regulated MHC class I... - Physical status of HPV types 16 and 18 in topographically different areas of genital tumours and in paired tumour-free mucosaGianna Badaracco
Laboratory of Virology, Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy
Int J Oncol 27:161-7. 2005.... - Plant-derived human papillomavirus 16 E7 oncoprotein induces immune response and specific tumor protectionRosella Franconi
Ente per le Nuove Tecnologie, Energia e Ambiente, UTS Biotech, Sezione Genetica e Genomica Vegetale, CR Casaccia, Rome, Italy
Cancer Res 62:3654-8. 2002..Our data support the possibility of producing a cost-effective anticancer vaccine in plant with intrinsic adjuvant-like properties... - Persistence of HPV after radio-chemotherapy in locally advanced cervical cancerGianna Badaracco
Division of Virology, Regina Elena Cancer Institute, Rome, Italy
Oncol Rep 23:1093-9. 2010..03) tool to assess the efficacy of the treatment... - Targeting endothelin receptor type A in human cervical carcinoma cellsAlessia Cirilli
Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
J Cardiovasc Pharmacol 44:S72-5. 2004..In conclusion, targeting the endothelin-A receptor, but not the endothelin-B receptor, may be a valid tool in the therapy of cervical carcinoma... - Human papillomavirus in head and neck carcinomas: prevalence, physical status and relationship with clinical/pathological parametersG Badaracco
Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
Anticancer Res 20:1301-5. 2000..The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer... - Both mucosal and cutaneous papillomaviruses are in the oral cavity but only alpha genus seems to be associated with cancerFrancesca Paolini
Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
J Clin Virol 56:72-6. 2013..The majority of published studies on HPV prevalence in these tumors concentrated on identifying high-risk mucosal types... - The E5 oncoprotein of human papillomavirus type 16 enhances endothelin-1-induced keratinocyte growthA Venuti
Laboratory of Virology, Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Institute for Cancer Research, CRS, Via delle Messi d Oro 156, Rome, 00158, Italy
Virology 248:1-5. 1998..In conclusion, our data demonstrate that E5 enhances ligand signaling in keratinocytes outside the EGF pathway by the amplification of the proliferative effect of ET-1/ETA receptor signaling... - Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growthA Bagnato
Laboratory of Molecular Pathology, Regina Elena Cancer Institute, Rome, Italy
Cancer Res 59:720-7. 1999..In conclusion, the present data demonstrate a novel mechanism in the growth control of ovarian carcinoma in vivo mediated by the ET-1 autocrine loop that selectively occurs via the ET(A)R... - Human papillomavirus type 5 in primary keratinocytes from psoriatic skinPaola Simeone
Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
Exp Dermatol 14:824-9. 2005.... - Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinomaFrancesca Paolini
Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
J Exp Clin Cancer Res 30:108. 2011..Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients... - Mutants of plant genes for developing cancer vaccinesSilvia Massa
ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, CR Casaccia, UT BIORAD FARM, Rome, Italy
Hum Vaccin 7:147-55. 2011..These data demonstrate that mutant plant genes hold promise to improve the poor immunogenicity of tumor-associated cancer antigens and could contribute to the evolution of new cancer immunotherapy... - Molecular analyses and prognostic relevance of HPV in head and neck tumoursGianna Badaracco
Laboratory of Virology, Regina Elena Cancer Institute, 00158 Rome, Italy
Oncol Rep 17:931-9. 2007.... - Human papillomavirus therapeutic vaccines in head and neck tumorsGianna Badaracco
Regina Elena Cancer Institute, Laboratory of Virology, Rome, Italy
Expert Rev Anticancer Ther 7:753-66. 2007..This article reviews what has been achieved and what remains to be done in the field for the development of future viral vaccines in head and neck tumors... - Predictors of human papilloma virus (HPV) infection in Italian womenM C Cercato
Department of Epidemiology, Regina Elena National Cancer Institute, Rome, Italy
J Med Virol 82:1921-7. 2010..These findings provide a contribution in the knowledge of an adult population defining a "high-risk" sexual behavioral profile and could be helpful to target prophylactic strategies in older woman... - HPV5b variant in a neoplastic lesion of an Italian patient affected by epidermodysplasia verruciformisL M Muscardin
Laboratory of Cutaneous Histopathology, Institute of Dermatology S Maria and San Gallicano, Via Chianesi, 53, 00144 Rome, Italy
Eur J Dermatol 11:572-5. 2001.... - UVB irradiation down-regulates HPV-16 RNA expression: implications for malignant progression of transformed cellsFederico De Marco
Laboratory of Virology, Regina Elena Institute for Cancer Research, V delle Messi d Oro, 156 00156 Rome, Italy
Virus Res 130:249-59. 2007..We propose that reported suppression of viral oncogenes, restoring the cell control on growth and repair mechanisms, allows the damage repair, ultimately resulting in a surviving response... - HPV16 and HPV18 in genital tumors: Significantly different levels of viral integration and correlation to tumor invasivenessGianna Badaracco
Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy
J Med Virol 67:574-82. 2002..In conclusion, virus typing in conjunction with the evaluation of the integration status may provide a better prognostic evaluation together with an improved diagnosis... - Role of endothelin-1 in neovascularization of ovarian carcinomaD Salani
Laboratories of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy
Am J Pathol 157:1537-47. 2000..These findings indicate that ET-1 could modulate tumor angiogenesis, acting directly and in part through VEGF... - The autonomous growth of human papillomavirus type 16-immortalized keratinocytes is related to the endothelin-1 autocrine loopA Venuti
Laboratory of Virology, Regina Elena Institute for Cancer Research, Rome, Italy
J Virol 71:6898-904. 1997..These data suggest a new mechanism in the growth control of HPV-transformed cells mediated by the upregulation of ET-1 autocrine loop... - Bovine papillomavirus type 4 in oesophageal papillomas of cattle from the south of ItalyG Borzacchiello
Department of Pathology and Animal Health, General Pathology and Infectious Diseases Division, Faculty of Veterinary Medicine, Naples University Federico II, Rome, Italy
J Comp Pathol 128:203-6. 2003..Nucleotide sequencing of the PCR amplicons confirmed the presence of BPV-4 in the papillomas. This is the first report of such infections in a European country other than Britain... - Merkel cell polyomavirus in Merkel cell carcinoma of Italian patientsFrancesca Paolini
Laboratory of Virology, Regina Elena Cancer Institute Via delle Messi d Oro 156 00158 Rome, Italy
Virol J 8:103. 2011..The main objective of the study was the detection of MCPyV and viral expression in clinical samples of Italian patients who were diagnosed MCC... - HPV 16 E7 antibody levels in cervical cancer patients: before and after treatmentA Di Lonardo
Laboratory of Virology, Regina Elena Institute for Cancer Research, Rome, Italy
J Med Virol 54:192-5. 1998..These results confirm the usefulness of studying anti-HPV16 E7 antibody profile in cervical cancer patients and suggest that the serum response correlates with tumour burden... - Egg yolk antibodies against the E7 oncogenic protein of human papillomavirus type 16A D Di Lonardo
Laboratory of Virology, Regina Elena Institute for Cancer Research, Rome, Italy
Arch Virol 146:117-25. 2001.... - Anti-cancer activity of plant-produced HPV16 E7 vaccineSilvia Massa
ENEA, Italian National Agency for New Technologies, Energy and the Environment, BAS BIOTEC GEN, C R Casaccia, Via Anguillarese 301, 00123 Rome, Italy
Vaccine 25:3018-21. 2007..Furthermore, when administered after challenge, these plant-produced antigens prevented tumor development... - Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinary bladder in cattleGiuseppe Borzacchiello
Department of Pathology and Animal Health, University of Naples Federico II, Via F Delpino, 1, 80137, Naples, Italy
Cancer Lett 250:82-91. 2007..Furthermore, the expression of the two viral oncoproteins confirm that the virus may have a causative role in the neoplastic process... - Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cowsGiuseppe Borzacchiello
Department of Pathology and Animal Health, Faculty of Veterinary medicine FEDERICO II Naples University, Via F Delpino, 1 80137 Naples, Italy
J Gen Virol 84:2921-6. 2003..Taken together, these data on naturally occurring bovine bladder tumours corroborate the hypothesis of their virus origin...