Oreste Segatto

Summary

Affiliation: Regina Elena Cancer Institute
Country: Italy

Publications

  1. pmc A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
    Yuri Frosi
    Istituto Regina Elena, Rome, Italy
    J Cell Biol 189:557-71. 2010
  2. doi request reprint Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors
    Oreste Segatto
    Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Cell Sci 124:1785-93. 2011
  3. ncbi request reprint Feedback inhibition by RALT controls signal output by the ErbB network
    Sergio Anastasi
    Regina Elena Cancer Institute, Via delle Messi d oro, 156, Rome 00158, Italy
    Oncogene 22:4221-34. 2003
  4. ncbi request reprint Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin
    Sergio Anastasi
    Laboratory of Immunology, Regina Elena Cancer Institute, Via delle Messi d oro, 156 158, 00158, Rome, Italy
    Oncogene 24:4540-8. 2005
  5. ncbi request reprint Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control
    Monia Fiorini
    Laboratory of Immunology, Istituto Regina Elena, 00156 Rome, Italy
    Oncogene 21:6530-9. 2002

Collaborators

  • Sigurdur Ingvarsson
  • Simona Polo
  • Sergio Anastasi
  • Stefano Alema
  • Gianluca Sala
  • Yuri Frosi
  • Monia Fiorini
  • Costanza Ballaro
  • Giulia Varsano
  • Elena Maspero
  • Loriana Castellani
  • Stefano Iacovelli
  • Elisabetta Caprini
  • Fabiana Lucini
  • Chen Huiping
  • Giandomenico Russo
  • L Castellani
  • Maurizio Alimandi
  • Rocco Fraioli
  • Loredana Fiorentino
  • Germana Falcone

Detail Information

Publications5

  1. pmc A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
    Yuri Frosi
    Istituto Regina Elena, Rome, Italy
    J Cell Biol 189:557-71. 2010
    ..These data suggest a model in which binding of RALT to EGFR integrates suppression of EGFR kinase with receptor endocytosis and degradation, leading to durable repression of EGFR signaling...
  2. doi request reprint Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors
    Oreste Segatto
    Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Cell Sci 124:1785-93. 2011
    ..Finally, we discuss how IFIs might participate in system control of EGFR signalling and highlight the emerging roles for IFIs in the suppression of EGFR-driven tumorigenesis...
  3. ncbi request reprint Feedback inhibition by RALT controls signal output by the ErbB network
    Sergio Anastasi
    Regina Elena Cancer Institute, Via delle Messi d oro, 156, Rome 00158, Italy
    Oncogene 22:4221-34. 2003
    ..We propose that quantitative and qualitative aspects of RALT signalling concur in defining identity, strength and duration of signals generated by the ErbB network...
  4. ncbi request reprint Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin
    Sergio Anastasi
    Laboratory of Immunology, Regina Elena Cancer Institute, Via delle Messi d oro, 156 158, 00158, Rome, Italy
    Oncogene 24:4540-8. 2005
    ..Thus, loss of RALT expression cooperates with ERBB2 gene amplification to drive full oncogenic signalling by the ErbB-2 receptor. Moreover, loss of RALT signalling may adversely affect tumor responses to ErbB-2-targeting agents...
  5. ncbi request reprint Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control
    Monia Fiorini
    Laboratory of Immunology, Istituto Regina Elena, 00156 Rome, Italy
    Oncogene 21:6530-9. 2002
    ..Such an integrated transcriptional and post-translational control is likely to provide RALT with the ability to fluctuate timely in order to tune ErbB signals...