Annamaria Biroccio

Summary

Affiliation: Regina Elena Cancer Institute
Country: Italy

Publications

  1. doi request reprint TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
    Annamaria Biroccio
    Laboratory of Molecular Biology of the Cell, CNRS UMR5239, IFR128, Ecole Normale Superieure de Lyon, Lyon 69364, France
    Nat Cell Biol 15:818-28. 2013
  2. pmc Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Rome 00158, Italy
    Neoplasia 6:195-206. 2004
  3. doi request reprint DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Tor Vergata University, Rome, Italy
    Clin Cancer Res 17:2227-36. 2011
  4. ncbi request reprint TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Experimental Research Centre, Regina Elena Cancer Institute, Via delle Messi d Oro 156, Rome 00158, Italy
    Eur J Cancer 42:1881-8. 2006
  5. ncbi request reprint Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d oro, 00158 Rome, Italy
    J Biol Chem 277:43763-70. 2002
  6. ncbi request reprint Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Biol Chem 278:35693-701. 2003
  7. ncbi request reprint Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, Rome, Italy
    Mol Pharmacol 63:632-8. 2003
  8. pmc Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
    Angela Rizzo
    Department of Experimental Chemotherapy, Regina Elena Cancer Institute, 00158 Rome, Italy
    Nucleic Acids Res 37:5353-64. 2009
  9. ncbi request reprint Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, University La Sapienza, Roma, Italy
    Mol Pharmacol 66:1138-46. 2004
  10. ncbi request reprint Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Prostate 67:1475-85. 2007

Collaborators

Detail Information

Publications34

  1. doi request reprint TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
    Annamaria Biroccio
    Laboratory of Molecular Biology of the Cell, CNRS UMR5239, IFR128, Ecole Normale Superieure de Lyon, Lyon 69364, France
    Nat Cell Biol 15:818-28. 2013
    ..Overall, these results reveal a TRF2-dependent pathway that is tumour-cell extrinsic and regulates NK cell immunity...
  2. pmc Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Rome 00158, Italy
    Neoplasia 6:195-206. 2004
    ..All together, these results demonstrate that GSH plays a key role in governing c-Myc-dependent drug-induced apoptosis...
  3. doi request reprint DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Tor Vergata University, Rome, Italy
    Clin Cancer Res 17:2227-36. 2011
    ..The present study aims at investigating the mechanisms involved in this specific drug interaction...
  4. ncbi request reprint TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Experimental Research Centre, Regina Elena Cancer Institute, Via delle Messi d Oro 156, Rome 00158, Italy
    Eur J Cancer 42:1881-8. 2006
    ..They further suggest that a basal level of telomere instability favours an efficient response to TRF2 inhibition and that a combined anti-TRF2 and G4-ligand therapy would have synergistic inhibitory effects on tumour cell growth...
  5. ncbi request reprint Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d oro, 00158 Rome, Italy
    J Biol Chem 277:43763-70. 2002
    ..The addition of N-acetyl-l-cysteine or glutathione ethyl ester inhibited the apoptotic process, thus confirming the key role of glutathione in programmed cell death induced by c-Myc...
  6. ncbi request reprint Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Biol Chem 278:35693-701. 2003
    ..Our results demonstrate that inhibition of c-Myc oncoprotein induces cellular crisis through cooperation between telomerase dysfunction and oxidative stress...
  7. ncbi request reprint Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, Rome, Italy
    Mol Pharmacol 63:632-8. 2003
    ..On the contrary, the hTERT-reconstituted cells progressed quickly through the cell cycle, thus acquiring the capacity to recover from drug-induced block and to protect themselves from the G(2)/M phase-specific drug-triggered apoptosis...
  8. pmc Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
    Angela Rizzo
    Department of Experimental Chemotherapy, Regina Elena Cancer Institute, 00158 Rome, Italy
    Nucleic Acids Res 37:5353-64. 2009
    ..The detailed understanding of the molecular mode of action of this class of compounds makes them attractive tools to understand telomere biology and provides the basis for a rational use of G4 ligands for the therapy of cancer...
  9. ncbi request reprint Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, University La Sapienza, Roma, Italy
    Mol Pharmacol 66:1138-46. 2004
    ..In conclusion, our results demonstrate that the G-quadruplex ligand RHPS4 can function in a telomere length-independent manner through its ability to cause telomere-capping alteration...
  10. ncbi request reprint Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Prostate 67:1475-85. 2007
    ..Since an increased expression of oncogenes, including c-myc and bcl-2, accompanies the transition to HRPC, we evaluated whether the concomitant downregulation of these oncogenes by antisense strategy sensitized HRPC to chemotherapy...
  11. doi request reprint G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Roma, Italy
    Clin Cancer Res 14:7284-91. 2008
    ..Here, we studied the therapeutic index of RHPS4 and its integration with chemotherapeutics in preclinical model of solid tumors...
  12. pmc Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
    Erica Salvati
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    J Clin Invest 117:3236-47. 2007
    ..They also define a functional link between telomere damage and antitumor activity and reveal the key role of telomere-protective factors TRF2 and POT1 in response to this anti-telomere strategy...
  13. pmc Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft
    Enrico P Spugnini
    S A F U Department, Regina Elena Cancer Institute, Via delle Messi d Oro 156, Rome 00158, Italy
    J Transl Med 9:125. 2011
    ..In this study we evaluated whether electroporation could increase the delivery of antisense oligodeoxynucleotides against bcl-2 (G3139) as well as the efficacy of combination chemotherapy in human melanoma xenografts...
  14. pmc Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
    Laura Rosanò
    Laboratories of Molecular Pathology, Experimental Chemotherapy, and Immunology, Regina Elena Cancer Institute, 00158 Rome, Italy
    Proc Natl Acad Sci U S A 106:2806-11. 2009
    ..ZD4054 treatment significantly inhibits metastases, suggesting that specific ET(A)R antagonists, by disabling multiple signaling activated by ET(A)R/beta-arrestin, may represent new therapeutic opportunities for ovarian cancer...
  15. ncbi request reprint Antisense clusterin oligodeoxynucleotides increase the response of HER-2 gene amplified breast cancer cells to Trastuzumab
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 204:463-9. 2005
    ..Altogether our findings suggest that combined targeting of HER-2 and CLU may represent a novel, rational approach to breast cancer therapy...
  16. ncbi request reprint Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 21:3011-9. 2002
    ..In conclusion, our results demonstrate that the reconstitution of high levels of telomerase activity reverses the low tumorigenicity due to low c-Myc expression...
  17. ncbi request reprint In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Int J Cancer 110:767-74. 2004
    ..Together, these results demonstrate the ability of VCR encapsulated in liposomes in sensitizing drug resistant tumors of different histotypes...
  18. ncbi request reprint Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells
    Barbara Benassi
    Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Mol Pharmacol 72:1015-23. 2007
    ..Thus, gamma-GCS impairment might specifically sensitize high c-Myc tumor cells to chemotherapy...
  19. ncbi request reprint c-Myc phosphorylation is required for cellular response to oxidative stress
    Barbara Benassi
    Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Rome, Italy
    Mol Cell 21:509-19. 2006
    ..Thus, the c-Myc phosphorylation-dependent activation of the GSH-directed survival pathway can contribute to oxidative stress resistance in tumor cells, which generally exhibit deregulated c-Myc expression...
  20. ncbi request reprint Potentiation of the antitumoral activity of gemcitabine and paclitaxel in combination on human breast cancer cells
    Gabriella Zupi
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Cancer Biol Ther 4:866-71. 2005
    ..In conclusion, this study suggests that paclitaxel is the most promising agent for combination protocols with gemcitabine and supports the use of gemcitabine/paclitaxel combination in the clinical management of advanced breast cancer...
  21. ncbi request reprint Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy
    Carlo Leonetti
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Int J Cancer 104:243-50. 2003
    ....
  22. doi request reprint Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells
    Daniela Stoppoloni
    Department for the Development of Therapeutic Programs, Regina Elena Cancer Institute, Rome, Italy
    J Thorac Oncol 6:583-91. 2011
    ..The aim of this study was to investigate the expression and biological activity of aromatase (CYP19A1) in malignant mesothelioma (MM)...
  23. doi request reprint Methods of studying telomere damage induced by quadruplex-ligand complexes
    Angela Rizzo
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Methods 57:93-9. 2012
    ..This review summarizes the most valid experimental approaches for studying the pharmacological telomere damage induced by G4-ligand complexes...
  24. ncbi request reprint Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity
    Angela Iervolino
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    FASEB J 16:1453-5. 2002
    ....
  25. ncbi request reprint Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Mol Pharmacol 63:192-202. 2003
    ..Moreover, the data presented here suggest that TMZ + PARP inhibitor combination is active against telomerase-suppressed and slowly growing tumors...
  26. ncbi request reprint The future of antisense therapy: combination with anticancer treatments
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 22:6579-88. 2003
    ..An overview of the progress of ASOs used in combination therapy is provided...
  27. ncbi request reprint Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy
    Andrea Pace
    Neuroscience Department, Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy
    J Clin Oncol 21:927-31. 2003
    ..The aim of this study is to evaluate the neuroprotective effect of antioxidant supplementation with vitamin E in patients treated with cisplatin chemotherapy...
  28. pmc Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis
    Erica Salvati
    Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy, Laboratory of Molecular Pathology, Department of Pharmacy, University of Naples Federico II, Naples, Italy, Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy, Laboratory of Molecular Pathology, Regina Elena National Cancer Institute, Rome, Italy, Institute for Research on Cancer and Aging, Nice IRCAN, Nice University, CNRS UMR7284 INSERM U1081, Faculty of Medicine, Nice, France and Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, France
    Nucleic Acids Res 42:2945-57. 2014
    ....
  29. ncbi request reprint Endothelin-1 acts as a survival factor in ovarian carcinoma cells
    Donatella Del Bufalo
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Clin Sci (Lond) 103:302S-305S. 2002
    ....
  30. ncbi request reprint Telomerase as a new target for the treatment of hormone-refractory prostate cancer
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Endocr Relat Cancer 11:407-21. 2004
    ....
  31. ncbi request reprint Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation
    Donatella Del Bufalo
    Experimental Chemotherapy Laboratories, Regina Elena Cancer Institute, Rome, Italy
    Mol Pharmacol 61:524-32. 2002
    ....
  32. ncbi request reprint ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells
    Fortunato Ciardiello
    Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita di Napoli Federico II, Naples, Italy
    Int J Cancer 98:463-9. 2002
    ..These results demonstrate the ability of ZD1839 to overcome taxane resistance in a model of hormone-independent, multidrug-resistant, human breast cancer...
  33. ncbi request reprint Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter
    Monica Di Padova
    Laboratory B
    J Biol Chem 278:36496-504. 2003
    ..Taken together, our results indicate that Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation...