Maria Benevolo

Summary

Affiliation: Regina Elena Cancer Institute
Country: Italy

Publications

  1. ncbi request reprint Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions
    Maria Benevolo
    Department of Pathology, Regina Elena Cancer Institute, Rome, Italy
    Mod Pathol 19:384-91. 2006
  2. pmc Prognostic value of HPV E6/E7 mRNA assay in women with negative colposcopy or CIN1 histology result: a follow-up study
    Paolo Giorgi Rossi
    Agency for Public Health Lazio Sanità, Rome, Italy
    PLoS ONE 8:e57600. 2013
  3. pmc High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis
    Maria Benevolo
    Department of Pathology, Regina Elena National Cancer Institute, Via E Chianesi 53, 00144 Rome, Italy
    J Transl Med 9:184. 2011
  4. pmc T and NK cells: two sides of tumor immunoevasion
    Doriana Fruci
    Paediatric Haematology Oncology Department, Bambino Gesu Children s Hospital, IRCCS, Piazza Sant Onofrio 4, Rome 00165, Italy
    J Transl Med 11:30. 2013
  5. pmc Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix
    Maria Benevolo
    Pathology Department, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    J Transl Med 10:132. 2012
  6. doi request reprint Comparative evaluation of nm23 and p16 expression as biomarkers of high-risk human papillomavirus infection and cervical intraepithelial neoplasia 2(+) lesions of the uterine cervix
    Maria Benevolo
    Departments of Pathology Epidemiology Scientific Direction Oncologic Gynecology, Regina Elena Cancer Institute, Rome, Italy
    Histopathology 57:580-6. 2010
  7. doi request reprint p16/Ki-67 dual staining in cervico-vaginal cytology: correlation with histology, Human Papillomavirus detection and genotyping in women undergoing colposcopy
    Maria Gabriella Donà
    STI Unit, San Gallicano Dermatological Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    Gynecol Oncol 126:198-202. 2012
  8. doi request reprint Performance of the linear array HPV genotyping test on paired cytological and formalin-fixed, paraffin-embedded cervical samples
    Maria Gabriella Donà
    Sexually Transmitted Infections Unit, San Gallicano Dermatological Institute, Rome, Italy
    J Mol Diagn 15:373-9. 2013
  9. doi request reprint Clinical role of p16INK4a expression in liquid-based cervical cytology: correlation with HPV testing and histologic diagnosis
    Maria Benevolo
    Pathology, Regina Elena Cancer Institute, Rome, Italy
    Am J Clin Pathol 129:606-12. 2008
  10. ncbi request reprint HLA-A, -B, -C expression in colon carcinoma mimics that of the normal colonic mucosa and is prognostically relevant
    Maria Benevolo
    Pathology Department, Regina Elena Cancer Institute CRS, Via delle Messi d Oro 156, 00158 Rome, Italy
    Am J Surg Pathol 31:76-84. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions
    Maria Benevolo
    Department of Pathology, Regina Elena Cancer Institute, Rome, Italy
    Mod Pathol 19:384-91. 2006
    ....
  2. pmc Prognostic value of HPV E6/E7 mRNA assay in women with negative colposcopy or CIN1 histology result: a follow-up study
    Paolo Giorgi Rossi
    Agency for Public Health Lazio Sanità, Rome, Italy
    PLoS ONE 8:e57600. 2013
    ....
  3. pmc High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis
    Maria Benevolo
    Department of Pathology, Regina Elena National Cancer Institute, Via E Chianesi 53, 00144 Rome, Italy
    J Transl Med 9:184. 2011
    ..In view of the opposing outcomes (activation or inhibition) of the different HLA-E receptors, the preferred role (if any) of HLA-E expressed in vivo on tumor cells remains to be established...
  4. pmc T and NK cells: two sides of tumor immunoevasion
    Doriana Fruci
    Paediatric Haematology Oncology Department, Bambino Gesu Children s Hospital, IRCCS, Piazza Sant Onofrio 4, Rome 00165, Italy
    J Transl Med 11:30. 2013
    ..Shared (T/NK cells) natural immunosuppressants and activating/inhibitory ligands expressed by tumor cells may provide mechanistic insight into impaired gathering and function of immune effectors at the tumor site...
  5. pmc Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix
    Maria Benevolo
    Pathology Department, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    J Transl Med 10:132. 2012
    ..Furthermore, high levels of claspin have been found in cervical cancer cell lines. Nevertheless, no data are available regarding claspin expression in cervical tissues...
  6. doi request reprint Comparative evaluation of nm23 and p16 expression as biomarkers of high-risk human papillomavirus infection and cervical intraepithelial neoplasia 2(+) lesions of the uterine cervix
    Maria Benevolo
    Departments of Pathology Epidemiology Scientific Direction Oncologic Gynecology, Regina Elena Cancer Institute, Rome, Italy
    Histopathology 57:580-6. 2010
    ....
  7. doi request reprint p16/Ki-67 dual staining in cervico-vaginal cytology: correlation with histology, Human Papillomavirus detection and genotyping in women undergoing colposcopy
    Maria Gabriella Donà
    STI Unit, San Gallicano Dermatological Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    Gynecol Oncol 126:198-202. 2012
    ....
  8. doi request reprint Performance of the linear array HPV genotyping test on paired cytological and formalin-fixed, paraffin-embedded cervical samples
    Maria Gabriella Donà
    Sexually Transmitted Infections Unit, San Gallicano Dermatological Institute, Rome, Italy
    J Mol Diagn 15:373-9. 2013
    ..In the present study, false-negative results were obtained in a limited percentage of cases, our data depicting the successful performance of the Linear Array test on FFPE samples...
  9. doi request reprint Clinical role of p16INK4a expression in liquid-based cervical cytology: correlation with HPV testing and histologic diagnosis
    Maria Benevolo
    Pathology, Regina Elena Cancer Institute, Rome, Italy
    Am J Clin Pathol 129:606-12. 2008
    ..These data suggest that p16 evaluation in ThinPrep samples does not have better clinical effectiveness for identifying high-grade lesions than conventional morphologic examination and HPV testing...
  10. ncbi request reprint HLA-A, -B, -C expression in colon carcinoma mimics that of the normal colonic mucosa and is prognostically relevant
    Maria Benevolo
    Pathology Department, Regina Elena Cancer Institute CRS, Via delle Messi d Oro 156, 00158 Rome, Italy
    Am J Surg Pathol 31:76-84. 2007
    ..Thus, a paired immunohistochemical comparison reveals a novel immune evasion strategy that may impact on the prognosis of colon carcinoma...
  11. doi request reprint Diagnostic and prognostic validity of the human papillomavirus E6/E7 mRNA test in cervical cytological samples of HC2-positive patients
    Maria Benevolo
    Pathology Department, Regina Elena Cancer Institute, Rome, Italy
    Cancer Causes Control 22:869-75. 2011
    ..The present data suggest that the mRNA test may have a diagnostic and a potentially prognostic role in HC2+/HSIL- patients...
  12. pmc Sensitivity, specificity, and clinical value of human papillomavirus (HPV) E6/E7 mRNA assay as a triage test for cervical cytology and HPV DNA test
    Maria Benevolo
    Agency for Public Health Lazio Sanità, Via di Santa Costanza 53, 00198 Rome, Italy
    J Clin Microbiol 49:2643-50. 2011
    ..It is also more efficient than cytology for the triage of HPV DNA-positive women. Nevertheless, its low sensitivity demands a strict follow-up of HPV DNA positive-mRNA negative cases...
  13. doi request reprint HPV prevalence among healthy Italian male sexual partners of women with cervical HPV infection
    Maria Benevolo
    Pathology Department, Regina Elena Cancer Institute, Rome, Italy
    J Med Virol 80:1275-81. 2008
    ....
  14. pmc Identification of episomal human papillomavirus and other DNA viruses in cytological anal samples of HIV-uninfected men who have sex with men
    Maria Gabriella Donà
    Sexually Transmitted Infection STI Unit, San Gallicano Dermatological Institute, Rome, Italy
    PLoS ONE 8:e72228. 2013
    ..Other DNA viruses were detected in the anal samples of these individuals, although the significance of this occurrence needs to be assessed. ..
  15. ncbi request reprint Chromogenic in situ hybridization to detect HER-2/neu gene amplification in histological and ThinPrep-processed breast cancer fine-needle aspirates: a sensitive and practical method in the trastuzumab era
    Amina Vocaturo
    Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy
    Oncologist 11:878-86. 2006
    ..Therefore, CISH analysis, which is avaluable and reproducible alternative to FISH for selecting breast cancer patients for trastuzumab therapy, can lower false-positive immunocytochemistry findings in ThinPrep-processed FNAs...
  16. ncbi request reprint Prognostic value of HER2 and progesterone receptor expression in endometrial carcinoma with positive peritoneal washing
    Maria Benevolo
    Departments of Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy
    Anticancer Res 27:2839-44. 2007
    ..In the present study, whether or not the analysis of multiple biopathological parameters might lead to more accurate predictions of the clinical outcome of EC patients with long-term follow-up (FU) was investigated...
  17. pmc Anal cytological abnormalities and epidemiological correlates among men who have sex with men at risk for HIV-1 infection
    Maria Gabriella Donà
    Sexually Transmitted Infections Unit, San Gallicano Dermatological Institute, Via Elio Chianesi 53, 00144 Rome, Italy
    BMC Cancer 12:476. 2012
    ....
  18. pmc Human papillomavirus prevalence and type-specific relative contribution in invasive cervical cancer specimens from Italy
    Luciano Mariani
    Regina Elena National Cancer Institute, Dept Gynecologic Oncology, Roma, Italy
    BMC Cancer 10:259. 2010
    ..Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific distribution in ICC have been conducted in Italy...
  19. doi request reprint Comparative evaluation of different DNA extraction methods for HPV genotyping by linear array and INNO-LiPA
    Maria Gabriella Donà
    Sexually Transmitted Infections STI Unit, San Gallicano Dermatological Institute, Rome, Italy
    J Med Virol 83:1042-7. 2011
    ..Consequently, different HPV type-specific profiles may be observed using different extracts of the same sample. The use of consistent protocols for DNA purification is a priority to guarantee intra-assay reproducibility over time...
  20. doi request reprint Prevalence, genotype diversity and determinants of anal HPV infection in HIV-uninfected men having sex with men
    Maria Gabriella Donà
    Sexually Transmitted Infections STI Unit, San Gallicano Dermatological Institute, Via Elio Chianesi 53, 00144 Rome, Italy
    J Clin Virol 54:185-9. 2012
    ..Anal human papillomavirus (HPV) infection is very common in men having sex with men (MSM), but the available data on its burden and characteristics mainly concern HIV-infected individuals...
  21. doi request reprint Melanoma molecular classes and prognosis in the postgenomic era
    Elisa Tremante
    Laboratory of Immunology, Regina Elena National Cancer Institute, Rome, Italy
    Lancet Oncol 13:e205-11. 2012
    ....
  22. pmc Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma
    Francesca Paolini
    Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
    J Exp Clin Cancer Res 30:108. 2011
    ..Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients...
  23. doi request reprint A melanoma immune response signature including Human Leukocyte Antigen-E
    Elisa Tremante
    Laboratory of Immunology, Regina Elena National Cancer Institute, Rome, Italy
    Pigment Cell Melanoma Res 27:103-12. 2014
    ..Although lacking HLA-E, melanocytes (4/4 cultures) were nevertheless (and surprisingly) fully protected from NK cell lysis. ..
  24. doi request reprint Human papillomavirus type 16 DNA detected in pulmonary metastases from a penile squamous cell carcinoma: a case study
    Laura Lorenzon
    University of Rome La Sapienza, Rome, Italy
    Int J Surg Pathol 21:59-62. 2013
    ..Indeed, according to the findings, the HPV genotyping test might help in the identification of metastatic disease from anogenital malignancies or other HPV-related cancers...
  25. ncbi request reprint Contribution of fluorescence in situ hybridization to immunohistochemistry for the evaluation of HER-2 in breast cancer
    Anna M Cianciulli
    Department of Clinical Pathology, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    Cancer Genet Cytogenet 133:66-71. 2002
    ..Our results indicate that with the combined use of both methods, several amplified samples classified negative by IHC can be used thus improving therapeutic planning for specific therapy with the monoclonal antibody trastuzumab...
  26. ncbi request reprint Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer
    Marcella Mottolese
    Department of Pathology, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 204:106-12. 2005
    ..Our data suggest that FasL could be a potential novel biomarker of transformation, which may identify, along with HER2 and p53, precursor lesions in a genetically altered breast tissue...
  27. ncbi request reprint Altered expression of FAS system is related to adverse clinical outcome in stage I-II breast cancer patients treated with adjuvant anthracycline-based chemotherapy
    Claudio Botti
    Regina Elena Cancer Institute, Rome, Italy, and University of Camerino, Camerino, Italy
    Clin Cancer Res 10:1360-5. 2004
    ..To determine the prognostic value of Fas receptor and Fas ligand (FasL) as apoptosis-related biomarkers in the context of chemoresponsiveness in breast cancer (BC) patients submitted to anthracycline-based adjuvant therapy...