Marco Ranucci

Summary

Country: Italy

Publications

  1. ncbi request reprint Anaerobic metabolism during cardiopulmonary bypass: predictive value of carbon dioxide derived parameters
    Marco Ranucci
    Department of Cardiothoracic Anesthesia, Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 81:2189-95. 2006
  2. doi request reprint Management of mini-cardiopulmonary bypass devices: is it worth the energy?
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, San Donato Milanese, Milan, Italy
    Curr Opin Anaesthesiol 22:78-83. 2009
  3. ncbi request reprint A prospective pilot study of platelet function and its relationship with postoperative bleeding in pediatric cardiac surgery
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Minerva Anestesiol 78:556-63. 2012
  4. doi request reprint Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic, IRCCS Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 96:478-85. 2013
  5. doi request reprint Preoperative antithrombin supplementation in cardiac surgery: a randomized controlled trial
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    J Thorac Cardiovasc Surg 145:1393-9. 2013
  6. doi request reprint Acute kidney injury in patients undergoing cardiac surgery and coronary angiography on the same day
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Donato, San Donato Milanese Milan, Italy
    Ann Thorac Surg 95:513-9. 2013
  7. ncbi request reprint Aortic cross-clamp time, new prostheses, and outcome in aortic valve replacement
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    J Heart Valve Dis 21:732-9. 2012
  8. doi request reprint Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 94:1134-41. 2012
  9. doi request reprint Monitoring prohemostatic treatment in bleeding patients
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Semin Thromb Hemost 38:282-91. 2012
  10. pmc Bivalirudin-based versus conventional heparin anticoagulation for postcardiotomy extracorporeal membrane oxygenation
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese Milan, Italy
    Crit Care 15:R275. 2011

Detail Information

Publications82

  1. ncbi request reprint Anaerobic metabolism during cardiopulmonary bypass: predictive value of carbon dioxide derived parameters
    Marco Ranucci
    Department of Cardiothoracic Anesthesia, Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 81:2189-95. 2006
    ..The present study is aimed to identify the possible predictors of hyperlactatemia during CPB among a series of oxygen and carbon dioxide derived parameters measured during CPB...
  2. doi request reprint Management of mini-cardiopulmonary bypass devices: is it worth the energy?
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, San Donato Milanese, Milan, Italy
    Curr Opin Anaesthesiol 22:78-83. 2009
    ..To address the role of mini-cardiopulmonary bypass systems in cardiac operations, with specific respect to clinical outcome...
  3. ncbi request reprint A prospective pilot study of platelet function and its relationship with postoperative bleeding in pediatric cardiac surgery
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Minerva Anestesiol 78:556-63. 2012
    ..Limited information on platelet function is available. This pilot study investigates platelet function changes in pediatric cardiac operations and their relationship with postoperative bleeding...
  4. doi request reprint Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic, IRCCS Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 96:478-85. 2013
    ..Preoperative anemia and RBC transfusions are recognized risk factors for operative mortality. The present study investigates the role of MB as an independent determinant of operative mortality in cardiac surgery...
  5. doi request reprint Preoperative antithrombin supplementation in cardiac surgery: a randomized controlled trial
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    J Thorac Cardiovasc Surg 145:1393-9. 2013
    ....
  6. doi request reprint Acute kidney injury in patients undergoing cardiac surgery and coronary angiography on the same day
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Donato, San Donato Milanese Milan, Italy
    Ann Thorac Surg 95:513-9. 2013
    ..The aim of this study is to investigate the risk of AKI in patients undergoing angiography and cardiac surgery on the same day, and to assess the efficacy of a policy limiting this practice...
  7. ncbi request reprint Aortic cross-clamp time, new prostheses, and outcome in aortic valve replacement
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    J Heart Valve Dis 21:732-9. 2012
    ....
  8. doi request reprint Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 94:1134-41. 2012
    ..The present study compares the postoperative outcome of a group of moderate-to-severe anemic patients with a propensity-matched group of nonanemic patients undergoing cardiac operations...
  9. doi request reprint Monitoring prohemostatic treatment in bleeding patients
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Semin Thromb Hemost 38:282-91. 2012
    ....
  10. pmc Bivalirudin-based versus conventional heparin anticoagulation for postcardiotomy extracorporeal membrane oxygenation
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese Milan, Italy
    Crit Care 15:R275. 2011
    ..Endpoints of this study are blood loss, allogeneic blood product use, and costs during the ECMO procedure...
  11. doi request reprint Effects of red blood cell transfusions on exercise tolerance and rehabilitation time after cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic Vascular Anesthesia, Intensive Care and Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy
    Transfus Apher Sci 45:299-303. 2011
    ..Conversely, the length of stay in the rehabilitation hospital was independently associated (P=0.004) with the number of packed red cells transfused, with an increase of 0.6 days per each unit transfused...
  12. doi request reprint Transfusions during cardiopulmonary bypass: better when triggered by venous oxygen saturation and oxygen extraction rate
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    Perfusion 26:327-33. 2011
    ..In conclusion, SvO(2) and O(2)ER are better than the hemoglobin value for guiding the decision-making process of red blood cell transfusions to correct hemodilutional anemia during CPB...
  13. doi request reprint Predicting transfusions in cardiac surgery: the easier, the better: the Transfusion Risk and Clinical Knowledge score
    M Ranucci
    Department of Cardiothoracic Vascular Anaesthesia and Intensive Care, IRCCS Policlinico S Donato, Via Morandi 30, San Donato Milanese, Milan, Italy
    Vox Sang 96:324-32. 2009
    ..The present study is aimed to develop and validate a risk score based on adequate statistical analyses joint with a clinical selection of a limited (five) number of preoperative predictors...
  14. doi request reprint Risk stratification in cardiac surgery
    Marco Ranucci
    Department of Anesthesiology, San Donato Hospital, Milan, Italy
    Semin Cardiothorac Vasc Anesth 14:66-7. 2010
    ..The main deficiency of all the risk models is that they cannot take into consideration the presence of extreme risk conditions which have a very low prevalence, but which are accompanied by a very high operative mortality rate...
  15. doi request reprint Living without aprotinin: the results of a 5-year blood saving program in cardiac surgery
    M Ranucci
    Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Acta Anaesthesiol Scand 53:573-80. 2009
    ....
  16. doi request reprint Near-infrared spectroscopy correlates with continuous superior vena cava oxygen saturation in pediatric cardiac surgery patients
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Paediatr Anaesth 18:1163-9. 2008
    ..In this study, we have compared the values of superior vena cava saturation (ScvO(2)) continuously measured with a Pediasat catheter and the corresponding NIRS rSO(2) values obtained during cardiac operations in pediatric patients...
  17. doi request reprint Surgical reexploration after cardiac operations: why a worse outcome?
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 86:1557-62. 2008
    ..In this study, we addressed the postoperative course of patients needing surgical reexploration, with specific respect to the timing of reexploration and the transfusional needs as determinants of morbidity and mortality...
  18. doi request reprint Postoperative anemia and exercise tolerance after cardiac operations in patients without transfusion: what hemoglobin level is acceptable?
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia, ICU and Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 92:25-31. 2011
    ..This study investigates the exercise tolerance during rehabilitation of cardiac surgical patients who did not receive transfusions, with respect to their level of postoperative anemia...
  19. doi request reprint Continuous monitoring of central venous oxygen saturation (Pediasat) in pediatric patients undergoing cardiac surgery: a validation study of a new technology
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    J Cardiothorac Vasc Anesth 22:847-52. 2008
    ..The present study was aimed at validating the accuracy of a new technology (Pediasat central venous catheter) in providing a continuous measurement of the central venous oxygen saturation in pediatric patients...
  20. doi request reprint A systematic review of biocompatible cardiopulmonary bypass circuits and clinical outcome
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 87:1311-9. 2009
    ..Using biocompatible surfaces without other measures to contain blood activation results in a limited clinical benefit...
  21. doi request reprint An adjusted EuroSCORE model for high-risk cardiac patients
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Eur J Cardiothorac Surg 36:791-7. 2009
    ..To verify the accuracy and precision of the logistic European system for cardiac operative risk evaluation (EuroSCORE) in high-risk cardiac surgery patients and to develop and externally validate a new system of recalibration...
  22. ncbi request reprint Effects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS S Donato Policlinic, Milan, Italy
    Minerva Anestesiol 76:249-59. 2010
    ..The present study is a prospective, randomized, double-blind placebo controlled trial conducted to determine the effects of fenoldopam in a population of patients undergoing complex cardiac operations...
  23. doi request reprint Hematocrit on cardiopulmonary bypass and outcome after coronary surgery in nontransfused patients
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Unit, IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 89:11-7. 2010
    ..This study aimed to identify the role of preoperative anemia and hemodilution during cardiopulmonary bypass as determinants of morbidity and mortality after coronary operations...
  24. doi request reprint Surgical and transcatheter aortic valve procedures. The limits of risk scores
    Marco Ranucci
    Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Interact Cardiovasc Thorac Surg 11:138-41. 2010
    ..These risk conditions should be included in a specific risk model for referring patients for TAVI...
  25. pmc Central venous oxygen saturation and blood lactate levels during cardiopulmonary bypass are associated with outcome after pediatric cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia and ICU, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Crit Care 14:R149. 2010
    ....
  26. pmc Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S, Donato, San Donato Milanese, Milan, 20097, Italy
    Crit Care 13:R207. 2009
    ..The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations...
  27. doi request reprint Accuracy, calibration and clinical performance of the EuroSCORE: can we reduce the number of variables?
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Eur J Cardiothorac Surg 37:724-9. 2010
    ..We hypothesised that too many variables were included in the EuroSCORE using limited patient series. We tested different models using a limited number of variables...
  28. doi request reprint Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, Istituto Di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 91:123-9. 2011
    ..The present study aimed to determine if a preoperative assessment of platelet function in these patients could provide clinically relevant information regarding the risks of excessive postoperative bleeding and transfusion requirements...
  29. doi request reprint Perioperative heart failure in coronary surgery and timing of intra-aortic balloon pump insertion
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Acta Anaesthesiol Scand 54:878-84. 2010
    ..The aim of this study was to investigate the operative mortality in perioperative HF patients who had undergone coronary operations with respect to the early or the late use of IABP...
  30. doi request reprint Risk of assessing mortality risk in elective cardiac operations: age, creatinine, ejection fraction, and the law of parsimony
    Marco Ranucci
    Director of Clinical Research in the Department of Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Circulation 119:3053-61. 2009
    ..The present study aims to develop and validate an operative mortality risk score for elective patients based on a limited number of factors...
  31. doi request reprint Hypothermic cardiopulmonary bypass as a determinant of late thrombocytopenia following cardiac operations in pediatric patients
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Acta Anaesthesiol Scand 53:1060-7. 2009
    ..This study explores the role of heparin-induced thrombocytopenia (HIT) and other factors (complexity of the operation, temperature management, and drug use) in determining LTCP...
  32. ncbi request reprint Hyperhomocysteinemia, antithrombin consumption, and early venous graft closure in surgical coronary revascularization
    M Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, Polyclinic Hospital S Donato IRCCS, Milan, Italy
    Minerva Anestesiol 74:439-42. 2008
    ..Further studies are needed to define hyperhomocysteinemia as an independent risk factor for thrombotic events after cardiac surgery...
  33. ncbi request reprint Determinants of antithrombin consumption in cardiac operations requiring cardiopulmonary bypass
    Marco Ranucci
    Department of Cardiothoracic Anaesthesia, Istituto Policlinico S Donato, Milan, Italy
    Perfusion 19:47-52. 2004
    ..001); age (p = 0.015); combined operation (p = 0.014); diabetes (p = 0.013) and CPB duration (p = 0.001). On this basis, predictive tables of AT consumption have been established for different combinations of risk factors...
  34. ncbi request reprint Reduced systemic heparin dose with phosphorylcholine coated closed circuit in coronary operations
    M Ranucci
    Department of Cardiothoracic Anesthesia, Istituto Policlinico S Donato, Cardiovascular Center E Malan, University of Milan, Milan, Italy
    Int J Artif Organs 27:311-9. 2004
    ..09-0.81, p = 0.02). A reduction of systemic anticoagulation is feasible with a non-heparin-bonded, closed biocompatible circuit, and results in a significant improvement of the outcome of low to moderate risk coronary patients...
  35. pmc Intensive care unit admission parameters improve the accuracy of operative mortality predictive models in cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Italy
    PLoS ONE 5:e13551. 2010
    ....
  36. ncbi request reprint Oxygen delivery during cardiopulmonary bypass and acute renal failure after coronary operations
    Marco Ranucci
    Department of Cardiothoracic Anesthesia and Intensive Care, Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 80:2213-20. 2005
    ..In this prospective observational study we have investigated the role of the lowest oxygen delivery, lowest hematocrit, and pump flow during cardiopulmonary bypass as possible risk factors for acute renal failure and renal dysfunction...
  37. ncbi request reprint The endothelial function in cardiac surgery
    M Ranucci
    Cardiothoracic Anesthesia and Intensive Care Department, Policlinico S Donato, Milan, Italy
    Minerva Anestesiol 72:503-6. 2006
    ....
  38. ncbi request reprint Closed, phosphorylcholine-coated circuit and reduction of systemic heparinization for cardiopulmonary bypass: the intraoperative ECMO concept
    M Ranucci
    Department of Cardiothoracic Anesthesia, Istituto Policlinico S Donato, University of Milan, Italy
    Int J Artif Organs 25:875-81. 2002
    ..This intraoperative ECMO approach offers promising results in terms of clinical outcome after coronary revascularization operations...
  39. pmc Which cardiac surgical patients can benefit from placement of a pulmonary artery catheter?
    Marco Ranucci
    Cardiothoracic Anesthesia and Intensive Care Department, Policlinico S, Donato, Milan, Italy
    Crit Care 10:S6. 2006
    ..This review highlights the specific role of PAC-derived haemodynamic data for each category...
  40. ncbi request reprint Determinants of early discharge from the intensive care unit after cardiac operations
    Marco Ranucci
    Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 83:1089-95. 2007
    ..We investigated the impact of a goal-oriented program aimed at discharging the patients from the intensive care unit the morning after the operation within a comprehensive model including other explanatory variables...
  41. pmc Minimally invasive cardiopulmonary bypass: does it really change the outcome?
    Marco Ranucci
    Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico S, Donato, Via Morandi 30, San Donato Milanese Milan 20097, Italy
    Crit Care 11:R45. 2007
    ..This study aimed to verify the clinical impact of an MICPB in a large population of patients undergoing coronary artery revascularization...
  42. ncbi request reprint Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy
    Marco Ranucci
    Department of Cardiothoracic and Vascular Anesthesia, IRCCS Policlinico S Donato, Milan, Italy
    J Cardiothorac Vasc Anesth 21:851-4. 2007
  43. doi request reprint Efficacy and safety of recombinant activated factor vii in major surgical procedures: systematic review and meta-analysis of randomized clinical trials
    Marco Ranucci
    Department of Cardiovascular Anaesthesia, IRCCS Policlinico S Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Arch Surg 143:296-304; discussion 304. 2008
    ..To investigate the efficacy and safety of recombinant activated factor VII (rFVIIa) treatment in patients undergoing major surgical procedures...
  44. ncbi request reprint Angioplasty in severe heart attack. Anesthesia and general management
    M Ranucci
    Istituto Policlinico S Donato, Department of Cardiothoracic Anesthesia, San Donato Milanese, Milan, Italy
    Minerva Anestesiol 68:192-5. 2002
    ..5 vs 0.4%), need for intra-aortic balloon pumping (14 vs 0.8%), use of antiaggregants and heparin...
  45. doi request reprint Perioperative renal failure: hypoperfusion during cardiopulmonary bypass?
    Marco Ranucci
    Department of Anestesia and Intensive Care, IRCCS Policlinico S Donato, San Donato Milanese, Milan, Italy
    Semin Cardiothorac Vasc Anesth 11:265-8. 2007
    ..During cardiopulmonary bypass, the pump flow should be coupled with the hematocrit to avoid falling below this critical oxygen delivery...
  46. pmc Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome
    Marco Ranucci
    Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico S, Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Crit Care 10:R167. 2006
    ....
  47. pmc O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management?
    Filip De Somer
    Department of Interventional and Surgical Cardiology, Heart Centre, Universitair Ziekenhuis Gent, De Pintelaan 185, B 9000 Gent, Belgium
    Crit Care 15:R192. 2011
    ..In this study, we explored the association between metabolic parameters (oxygen delivery (DO2) and carbon dioxide production (VCO2)) during CPB with postoperative AKI...
  48. doi request reprint Invited commentary
    Marco Ranucci
    Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Via Morandi 30 San Donato Milanese, Milan, 20097, Italy
    Ann Thorac Surg 85:617. 2008
  49. doi request reprint Body size, gender, and transfusions as determinants of outcome after coronary operations
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 85:481-6. 2008
    ..Because these clinical conditions are interrelated, we designed a study to investigate their respective roles in determining adverse outcomes after coronary operations...
  50. ncbi request reprint Gabexate mesilate and heparin responsiveness in coronary patients
    Marco Ranucci
    Department of Cardiothoracic Anesthesia, Istituto Policlinico S Donato, Milan, Italy
    Med Sci Monit 10:PI40-3. 2004
    ..The aim of this study was to determine the effectiveness of a novel serine proteases inhibitor (gabexate mesilate) in increasing heparin responsiveness...
  51. doi request reprint N-terminal pro-brain natriuretic peptide and outcomes in patients undergoing surgical ventricular restoration
    Andrea Ballotta
    Department of Cardiothoracic Anesthesia and Intensive Care Unit, 20097 San Donato Milanese, Milan, Italy
    Am J Cardiol 105:640-4. 2010
    ..In conclusion, preoperative NT-pro-BNP determination may be of value in stratifying the risk for major morbidity after SVR...
  52. doi request reprint Cardiac catheterization and postoperative acute kidney failure in congenital heart pediatric patients
    Paolo Bianchi
    Departments of Cardiothoracic Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Policlinico San Donato Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Anesth Analg 117:455-61. 2013
    ..In the present study, we explored the association between timing of angiography, dose of contrast media, and the incidence of ARF after cardiac operations in pediatric patients...
  53. doi request reprint Impact of surgical ventricular restoration on diastolic function: implications of shape and residual ventricular size
    Serenella Castelvecchio
    Department of Cardiac Surgery, IRCCS, San Donato Hospital, Milan, Italy
    Ann Thorac Surg 86:1849-54. 2008
    ..The purpose of this study was to assess postoperative diastolic function changes and identify potential predictors of its worsening...
  54. ncbi request reprint The antithrombin III-saving effect of reduced systemic heparinization and heparin-coated circuits
    Marco Ranucci
    Departments of Cardiothoracic Anesthesia and Cardiac Surgery, Cardiovascular Center E Malan University of Milan, Istituto Policlinico S Donato, Milan, Italy
    J Cardiothorac Vasc Anesth 16:316-20. 2002
    ..To investigate the perioperative changes of antithrombin III (AT-III) activity using reduced systemic heparinization and the possible role of AT-III in determining a better postoperative outcome...
  55. doi request reprint Effects of surgical ventricular reconstruction on diastolic function at midterm follow-up
    Marisa Di Donato
    Department of Cardiac Surgery, IRCCS San Donato Hospital, Milan, Italy
    J Thorac Cardiovasc Surg 140:285-291.e1. 2010
    ....
  56. pmc Lowest hematocrit on cardiopulmonary bypass impairs the outcome in coronary surgery: An Italian Multicenter Study from the National Cardioanesthesia Database
    Marco Ranucci
    Istituto Policlinico S Donato, 20097 San Donato Milanese Milan, Italy
    Tex Heart Inst J 33:300-5. 2006
    ..Anemia upon cardiopulmonary bypass was not associated with death. Our findings confirm that both severe anemia and blood transfusions were significantly associated with renal failure and low-output syndrome...
  57. ncbi request reprint Different patterns of heparin resistance: therapeutic implications
    Marco Ranucci
    Department of Cardiothoracic Anaesthesia, Cardiovascular Centre E Malan, University of Milan, Istituto Policlinico S Donato, Italy
    Perfusion 17:199-204. 2002
    ..Unlike the other heparin-resistant patients, these subjects do not respond to AT III supplementation aimed at reaching supranormal AT III activity values...
  58. doi request reprint The easier, the better: age, creatinine, ejection fraction score for operative mortality risk stratification in a series of 29,659 patients undergoing elective cardiac surgery
    Marco Ranucci
    IRCCS Policlinico San Donato, Milan, Italy
    J Thorac Cardiovasc Surg 142:581-6. 2011
    ..We validate the age, creatinine, ejection fraction score in a large multicentric study...
  59. ncbi request reprint Postoperative antithrombin levels and outcome in cardiac operations
    Marco Ranucci
    Department of Cardiothoracic Anesthesia and Intensive Care, Istituto Policlinico S Donato, Milan, Italy
    Crit Care Med 33:355-60. 2005
    ..This study investigates the association between antithrombin activity at admission to the ICU (ICU-antithrombin activity) and various outcome variables...
  60. pmc Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S Donato, Milan, Italy
    Eur Heart J 30:995-1004. 2009
    ..Whether elevated homocysteine further increases the morbidity and mortality in patients undergoing cardiac surgery on cardiopulmonary bypass (CPB) (a prothrombotic state itself) remains less known...
  61. doi request reprint The effectiveness of different functional fibrinogen polymerization assays in eliminating platelet contribution to clot strength in thromboelastometry
    Christoph J Schlimp
    From the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and AUVA Research Centre, Vienna Department of Anesthesiology and Intensive Care, Salzburger Landeskliniken SALK, Salzburg, Austria CSL Behring, Marburg, Germany Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy and Department of Anesthesiology and Intensive Care, AUVA Trauma Hospital of Salzburg, Salzburg, Austria
    Anesth Analg 118:269-76. 2014
    ..Incomplete platelet inhibition influences maximum clot firmness (MCF) of FFPAs. We compared the ability of existing and newly developed FFPAs to eliminate the platelet contribution to clot strength...
  62. doi request reprint Accuracy, calibration and clinical performance of the new EuroSCORE II risk stratification system
    Umberto Di Dedda
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy
    Eur J Cardiothorac Surg 43:27-32. 2013
    ..This study presents a validation series for the EuroSCORE II compared with the previous additive and the logistic EuroSCORE and with the Age, Creatinine and Ejection Fraction (ACEF) score...
  63. doi request reprint Influence of the timing of cardiac catheterization and the amount of contrast media on acute renal failure after cardiac surgery
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, Policlinico S Donato, Milan, Italy
    Am J Cardiol 101:1112-8. 2008
    ....
  64. ncbi request reprint Surgical therapy for ischemic heart failure: single-center experience with surgical anterior ventricular restoration
    Lorenzo Menicanti
    Cardiac Surgery Department, San Donato Hospital, Milano, Italy
    J Thorac Cardiovasc Surg 134:433-41. 2007
    ....
  65. ncbi request reprint Moderate ischemic mitral regurgitation and coronary artery bypass surgery: effect of mitral repair on clinical outcome
    Marisa Di Donato
    San Donato Hospital, San Donato Milanese, Milan, Italy
    J Heart Valve Dis 12:272-9. 2003
    ..The study aim was to determine whether mitral repair associated with CABG is preferable to CABG alone in patients with moderate ischemic MR, in terms of intermediate outcome...
  66. doi request reprint Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis
    Giovanni Landoni
    Department of Cardiothoracic Anesthesia and Intensive Care, Universita Vita Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milan, Italy
    J Cardiothorac Vasc Anesth 22:27-33. 2008
    ..To determine the efficacy of fenoldopam in the prevention of acute renal failure, the authors performed a systematic review of randomized, controlled trials and propensity-matched studies in patients undergoing cardiovascular surgery...
  67. doi request reprint Neoaortic valve and root complex evolution after Ross operation in infants, children, and adolescents
    Alessandro Frigiola
    Department of Cardiac Surgery, IRCCS Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 90:1278-85. 2010
    ..The Ross operation in children and adolescents offers many potential advantages. Concerns have been raised about the long-term development of the neoaortic complex and the risk of dilation...
  68. doi request reprint Morbidity and mortality risk factors in adults with congenital heart disease undergoing cardiac reoperations
    Alessandro Giamberti
    Department of Cardiac Surgery and Grown Up Congenital Heart Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, San Donato Milanese, Milan, Italy
    Ann Thorac Surg 88:1284-9. 2009
    ..Cardiac operations in these patients present major difficulties in management and technique. Although reoperations in ACHD are becoming increasingly frequent, limited knowledge exists regarding perioperative risk factors...
  69. ncbi request reprint Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients
    Marco Ranucci
    Cardiothoracic Anesthesia and Intensive Care, Istituto Policlinico S Donato, Milan, Italy
    Ann Thorac Surg 78:1332-7; discussion 1337-8. 2004
    ..The aim of this study was to determine if prophylactic treatment with fenoldopam mesylate of patients at high risk of postoperative acute renal failure reduced the incidence of this event...
  70. doi request reprint Tracheostomy after cardiac operations: in-hospital and long-term survival
    Andrea Ballotta
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 92:528-33. 2011
    ..This study determined the hospital and postdischarge outcome in a series of patients who underwent a tracheostomy due to ventilator dependency after cardiac operations...
  71. doi request reprint Comparison of morbidity and mortality in diabetics versus nondiabetics having isolated coronary bypass versus coronary bypass plus valve operations versus isolated valve operations
    Serenella Castelvecchio
    Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy
    Am J Cardiol 107:535-9. 2011
    ..Although diabetic patients undergoing coronary operations are not at increased risk of operative mortality, morbidity is significantly affected in the overall population...
  72. doi request reprint The Ross procedure in adults: long-term follow-up and echocardiographic changes leading to pulmonary autograft reoperation
    Alessandro Frigiola
    Department of Cardiac Surgery, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 86:482-9. 2008
    ..The secondary end points are to explore the incidence of neoaortic root dilation and valve regurgitation, and the echocardiographic profile leading to a reoperation...
  73. doi request reprint Desmopressin reduces transfusion needs after surgery: a meta-analysis of randomized clinical trials
    Giuseppe Crescenzi
    Department of Cardiothoracic Anesthesia and Intensive Care, Universita Vita Salute San Raffaele, Milano, Italy
    Anesthesiology 109:1063-76. 2008
    ..The authors performed a meta-analysis of 38 randomized, placebo-controlled trials (2,488 patients) investigating desmopressin in surgery and indicating at least perioperative blood loss or transfusion of blood products...
  74. ncbi request reprint Functional tricuspid valve regurgitation in adults with congenital heart disease: an emerging problem
    Alessandro Giamberti
    Department of Cardiac Surgery GUCH Unit, IRCCS Policlinico San Donato, San Donato, Italy
    J Heart Valve Dis 20:565-70. 2011
    ..The study aim was to resolve this problem by evaluating results obtained from patients after surgical treatment of ACHD...
  75. doi request reprint Diabetes mellitus and long-term outcome in heart failure patients after surgical ventricular restoration
    Serenella Castelvecchio
    Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy
    Ann Thorac Surg 88:1451-6. 2009
    ..Reported prognostic predictors for late morbidity and mortality are predominantly related to cardiac conditions, whereas the prognostic impact of comorbidities still needs to be defined...
  76. ncbi request reprint Predictors for heparin resistance in patients undergoing coronary artery bypass grafting
    M Ranucci
    Department of Cardiovascular Anaesthesia, University of Milan, San Donato Hospital, Italy
    Perfusion 14:437-42. 1999
    ..We conclude that HR is a predictable event. In the presence of all the risk factors, the likelihood of HR is 99%; in the absence of all of them, it is 10%. Predicting HR allows us to apply many possible therapeutic strategies...
  77. doi request reprint J wave, QRS slurring, and ST elevation in athletes with cardiac arrest in the absence of heart disease: marker of risk or innocent bystander?
    Riccardo Cappato
    Arrhythmia and Electrophysiology Center, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese, Milan, Italy
    Circ Arrhythm Electrophysiol 3:305-11. 2010
    ..The aim of our study was to investigate whether QRS-ST changes are markers of cardiac arrest (CA) of unexplained cause or sudden death in athletes...
  78. ncbi request reprint Gabexate mesilate and antithrombin III for intraoperative anticoagulation in heparin pretreated patients
    M Ranucci
    Department of Cardiac Anaesthesia, Cardiovascular Centre E Malan, S Donato Hospital, University of Milan, Italy
    Perfusion 14:357-62. 1999
    ..Purified AT-III administration is recommended in heparin pretreated patients; the addition of gabexate mesilate to this protocol decreases the heparin requirement and increases the AT-III preservation...
  79. ncbi request reprint Risk factors for fatal myocardial infarction after coronary bypass graft surgery
    M Ranucci
    Departments of Cardiovascular Anesthesia and Cardiac Surgery, Cardiovascular Center E. Malan, University of Milan, San Donato Hospital, Milan, Italy
    Eur J Anaesthesiol 18:322-9. 2001
    ..Patterns of heparin resistance, whether or not due to heparin pretreatment, seem to be closely related to fatal myocardial infarction...
  80. ncbi request reprint Antithrombin III. Key factor in extracorporeal circulation
    M Ranucci
    Istituto Policlinico S Donato, Department of Cardiothoracic Anesthesia, San Donato Milanese Milan, Italy
    Minerva Anestesiol 68:454-7. 2002
    ..Finally, the anti-inflammatory properties of antithrombin III in the setting of the "whole body inflammatory reaction" induced by the cardiopulmonary bypass represents a new and unexplored field of research...
  81. ncbi request reprint Impact of oligon central venous catheters on catheter colonization and catheter-related bloodstream infection
    Marco Ranucci
    Department of Cardiothoracic Anesthesia, Istituto Policlinico S Donato, Milan, Italy
    Crit Care Med 31:52-9. 2003
    ..To evaluate a new antimicrobial treatment for central venous catheters in comparison with a traditional treatment, by assessing the catheter colonization and catheter-related bloodstream infection rates in two groups of patients...
  82. ncbi request reprint Ischemic mitral regurgitation: intraventricular papillary muscle imbrication without mitral ring during left ventricular restoration
    L Menicanti
    Department of Cardiac Surgery, Istituto Policlinico San Donato, San Donato Milanese, Milan, Italy
    J Thorac Cardiovasc Surg 123:1041-50. 2002
    ..This surgical approach consists of endoventricular mitral repair without prosthetic ring, ventricular reconstruction with or without patch, and coronary artery bypass grafting...