Paolo Puccetti

Summary

Country: Italy

Publications

  1. ncbi request reprint On watching the watchers: IDO and type I/II IFN
    Paolo Puccetti
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 37:876-9. 2007
  2. ncbi request reprint Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism
    Paolo Puccetti
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood Cells Mol Dis 40:101-5. 2008
  3. ncbi request reprint IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation
    Paolo Puccetti
    Paolo Puccetti and Ursula Grohmann are at the Department of Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia 06126, Italy
    Nat Rev Immunol 7:817-23. 2007
  4. ncbi request reprint Effects of IL-12 and IL-23 on antigen-presenting cells at the interface between innate and adaptive immunity
    Paolo Puccetti
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Crit Rev Immunol 22:373-90. 2002
  5. ncbi request reprint Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Italy
    J Immunol 174:6582-6. 2005
  6. ncbi request reprint The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 176:6752-61. 2006
  7. doi request reprint Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
  8. ncbi request reprint Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    J Immunol 171:2581-7. 2003
  9. ncbi request reprint Tryptophan catabolism generates autoimmune-preventive regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Transpl Immunol 17:58-60. 2006
  10. pmc SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Proc Natl Acad Sci U S A 105:20828-33. 2008

Collaborators

Detail Information

Publications64

  1. ncbi request reprint On watching the watchers: IDO and type I/II IFN
    Paolo Puccetti
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 37:876-9. 2007
    ..Such a bidirectional feedback loop could be part of an integrated response for preventing excessive inflammation and autoimmunity...
  2. ncbi request reprint Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism
    Paolo Puccetti
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood Cells Mol Dis 40:101-5. 2008
    ..Therefore, although pDCs do not express IDO-dependent tolerance constitutively, multiple ligands and cytokines will contribute to the expression of a tolerogenic phenotype by those cells...
  3. ncbi request reprint IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation
    Paolo Puccetti
    Paolo Puccetti and Ursula Grohmann are at the Department of Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia 06126, Italy
    Nat Rev Immunol 7:817-23. 2007
    ..This mechanism may also underlie the protective function of glucocorticoids in pathological conditions...
  4. ncbi request reprint Effects of IL-12 and IL-23 on antigen-presenting cells at the interface between innate and adaptive immunity
    Paolo Puccetti
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Crit Rev Immunol 22:373-90. 2002
    ..This review summarizes recent data on the actions of IL-12 and IL-23 on dendritic cells and macrophages at the interface between innate and adaptive immunity...
  5. ncbi request reprint Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Italy
    J Immunol 174:6582-6. 2005
    ..Thus, in the absence of SOCS3, CD28-Ig becomes immunosuppressive and mimics the action of CTLA-4-Ig on tryptophan catabolism...
  6. ncbi request reprint The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 176:6752-61. 2006
    ....
  7. doi request reprint Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step...
  8. ncbi request reprint Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    J Immunol 171:2581-7. 2003
    ..Thus, environmental conditioning by T cell ligands may alter the default function of DC subsets to meet the needs of flexibility and redundancy...
  9. ncbi request reprint Tryptophan catabolism generates autoimmune-preventive regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Transpl Immunol 17:58-60. 2006
    ..These cells are capable of effective control of diabetogenic T cells in vivo...
  10. pmc SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Proc Natl Acad Sci U S A 105:20828-33. 2008
    ..In addition to identifying SOCS3 as a candidate signature for mouse DC subsets programmed to direct immunity, this study demonstrates that IDO undergoes regulatory proteolysis in response to immunogenic stimuli...
  11. doi request reprint IDO mediates TLR9-driven protection from experimental autoimmune diabetes
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:6303-12. 2009
    ..Thus, our data suggest that the TLR9-IDO axis may represent a valuable target in the prevention/therapy of type 1 diabetes...
  12. ncbi request reprint A crucial role for tryptophan catabolism at the host/Candida albicans interface
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 174:2910-8. 2005
    ..The production of IFN-gamma may be squarely placed at this interface, where IDO activation probably exerts a fine control over fungal morphology as well as inflammatory and adaptive antifungal responses...
  13. ncbi request reprint Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes
    Maria Laura Belladonna
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Transplantation 84:S17-20. 2007
    ....
  14. ncbi request reprint Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance
    Luigina Romani
    Microbiology Section, Department of Experimental Medicine, and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Ann N Y Acad Sci 1112:326-38. 2007
    ....
  15. ncbi request reprint Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism
    Claudia Montagnoli
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Italy
    J Immunol 176:1712-23. 2006
    ..Thus, regulation is an essential component of the host response in infection and allergy to the fungus, and its manipulation may allow the pathogen to overcome host resistance and promote disease...
  16. doi request reprint High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway
    Claudia Volpi
    Department of Experimental Medicine, University of Perugia, Perugia 06126, Italy
    Nat Commun 4:1852. 2013
    ..Our findings may be relevant to an increased understanding of the complexity of Toll-like receptor signalling and optimal exploitation of CpG-rich oligodeoxynucleotides as immune modulators...
  17. ncbi request reprint CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig
    Carmine Vacca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Microbes Infect 7:1040-8. 2005
    ..However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4...
  18. ncbi request reprint Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    J Immunol 177:130-7. 2006
    ..The paracrine production of kynurenines might be one mechanism used by IDO-competent cells to convert DCs lacking functional IDO to a tolerogenic phenotype within an IFN-gamma-rich environment...
  19. ncbi request reprint IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 37:2695-706. 2007
    ..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi...
  20. ncbi request reprint Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Adv Exp Med Biol 590:209-21. 2007
  21. ncbi request reprint CTLA-4-Ig regulates tryptophan catabolism in vivo
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 3:1097-101. 2002
    ..These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals...
  22. ncbi request reprint Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, Section of Pharmacology, University of Perugia, 06126 Perugia, Italy
    Int Immunol 17:1429-38. 2005
    ..Therefore, although pDCs do not mediate IDO-dependent tolerance constitutively, multiple ligands and cytokines will contribute to the expression of a tolerogenic phenotype by pDCs in the mouse...
  23. pmc A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    J Exp Med 198:153-60. 2003
    ..This is the first report of an experimental autoimmune disease in which defective tolerance is causally linked to impaired tryptophan catabolism...
  24. ncbi request reprint Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 181:5194-8. 2008
    ..These data are the first to link TGF-beta signaling with IDO in controlling spontaneous tolerogenesis by DCs...
  25. ncbi request reprint CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 5:1134-42. 2004
    ..Thus, different ligands of B7 can signal dendritic cells to express functionally distinct effector responses...
  26. ncbi request reprint Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    Ciriana Orabona
    Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood 107:2846-54. 2006
    ..Overall, these studies reveal the occurrence of a simple and evolutionarily conserved code in the control of tolerance by an ancestral metabolic enzyme...
  27. ncbi request reprint Modulation of tryptophan catabolism by regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 4:1206-12. 2003
    ..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells...
  28. ncbi request reprint Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 180:4022-31. 2008
    ..TIR8 may contribute toward fine-tuning the balance between protective immunity and immunopathology in infection...
  29. ncbi request reprint Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 173:3748-54. 2004
    ..These data prospect novel functions for both pDCs and the CD200-CD200R pair in the mouse. At the same time, these data underscore the possible unifying role of the IDO mechanism in immune tolerance...
  30. doi request reprint Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
    Maria T Pallotta
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Nat Immunol 12:870-8. 2011
    ..Thus, IDO has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts...
  31. ncbi request reprint Tryptophan catabolism in nonobese diabetic mice
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Adv Exp Med Biol 527:47-54. 2003
    ..This finding correlates with a low expression of IDO activity, thus suggesting that poor expression of IDO by dendritic cells may play a role in the development of diabetes...
  32. ncbi request reprint Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance
    Luigina Romani
    Dept of Experimental Medicine, Section of Microbiology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Blood 108:2265-74. 2006
    ..Thus, instructive immunotherapy with Talpha1 targeting IDO-competent DCs could allow for a balanced control of inflammation and tolerance...
  33. ncbi request reprint Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 35:3111-8. 2005
    ..Increased resistance to experimental encephalomyelitis is observed in DAP12 knockin mice, which is dependent on IDO expression. Therefore, DAP12-related receptors act as negative regulators of IDO-mediated tolerance in vivo...
  34. ncbi request reprint Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 179:5999-6008. 2007
    ..This is the first study to show that the same tryptophan catabolites can foster dendritic cell-supported generation of Foxp3(+) cells and mediate, at the same time, inhibition of RORgammat-expressing T cells...
  35. doi request reprint A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression
    Claudia Volpi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06126, Italy
    J Immunol 189:2283-9. 2012
    ..Among potentially therapeutic ODNs, this study identifies GpC-rich sequences as novel activators of TLR7-mediated, IDO-dependent regulatory responses...
  36. doi request reprint Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy to Aspergillus
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences and Fondazione, Istituto di Ricovero e Cura per le Biotecnologie Trapiantologiche, Perugia, Italy
    Med Mycol 47:S154-61. 2009
    ....
  37. pmc CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia 06126, Italy
    J Exp Med 200:1051-62. 2004
    ....
  38. ncbi request reprint T cell apoptosis by kynurenines
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Italy
    Adv Exp Med Biol 527:183-90. 2003
    ..These data may represent the first experimental evidence for the involvement of tryptophan catabolism in the regulation of T cell apoptosis and maintenance of peripheral T cell tolerance...
  39. doi request reprint Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06132, Italy
    Immunity 39:372-85. 2013
    ..Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism. ..
  40. ncbi request reprint Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
    Ursula Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Nat Med 13:579-86. 2007
    ..Induction of IDO could be an important mechanism underlying the anti-inflammatory action of corticosteroids...
  41. ncbi request reprint IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 180:5157-62. 2008
    ..Recent data support a view in which IL-23/IL-17 antagonistic strategies, including the administration of synthetic kynurenines, could represent a new means of harnessing progressive or potentially harmful inflammation...
  42. ncbi request reprint Controlling pathogenic inflammation to fungi
    Luigina Romani
    University of Perugia, Department of Experimental Medicine and Biochemical Sciences, Via del Giochetto, 06122 Perugia, Italy
    Expert Rev Anti Infect Ther 5:1007-17. 2007
    ....
  43. ncbi request reprint Xenograft of microencapsulated sertoli cells reverses T1DM in NOD mice by inducing neogenesis of beta-cells
    Giovanni Luca
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Transplantation 90:1352-7. 2010
    ....
  44. ncbi request reprint CD40 ligand and CTLA-4 are reciprocally regulated in the Th1 cell proliferative response sustained by CD8(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 169:1182-8. 2002
    ..In addition, they suggest that reciprocal regulation of CD40 ligand and CTLA-4 expression occurs in Th1 cells exposed to CD8(+) DCs...
  45. doi request reprint TGF-beta and kynurenines as the key to infectious tolerance
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Trends Mol Med 15:41-9. 2009
    ..Current molecular insights suggest a synergistic potential for TGF-beta and IDO in physiologically or therapeutically opposing human pathologies sustained by over-reacting immune responses...
  46. ncbi request reprint IL-23 neutralization protects mice from Gram-negative endotoxic shock
    Maria Laura Belladonna
    Department of Experimental Medicine and Biochemical Sciences, Section of Pharmacology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Cytokine 34:161-9. 2006
    ..aeruginosa-challenged mice was associated with a dramatic decrease in circulating levels of the pathogenetic cytokines, TNF-alpha and IFN-gamma. Hence, IL-23 may represent a new therapeutic target in Gram-negative endotoxic shock...
  47. doi request reprint Indoleamine 2,3-dioxygenase: from catalyst to signaling function
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 42:1932-7. 2012
    ..All these aspects are covered in this review...
  48. doi request reprint Immune regulation and tolerance to fungi in the lungs and skin
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Chem Immunol Allergy 94:124-37. 2008
    ..IDO and tryptophan metabolites may prove to be potent regulators capable of taming overzealous or heightened inflammatory host responses...
  49. ncbi request reprint Tolerance, DCs and tryptophan: much ado about IDO
    Ursula Grohmann
    Department of Experimental Medicine, Via del Giochetto, University of Perugia, 06126 Perugia, Italy
    Trends Immunol 24:242-8. 2003
  50. doi request reprint Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Microbes Infect 11:133-41. 2009
    ..This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions...
  51. ncbi request reprint IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
    Maria Laura Belladonna
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 168:5448-54. 2002
    ..In addition, the in vitro effects of IL-23-Ig did not appear to require IL-12Rbeta2 or to be mediated by the production of IL-12. These data may establish IL-23 as a novel cytokine with major effects on APC...
  52. doi request reprint Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Nat Med 16:897-902. 2010
    ..The high amounts of glutamate in neuroinflammation might reflect a counterregulatory mechanism that is protective in nature and might be harnessed therapeutically for restricting immunopathology in multiple sclerosis...
  53. doi request reprint Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines
    Rossana G Iannitti
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Perugia, Italy
    Am J Respir Crit Care Med 187:609-20. 2013
    ..The appreciation of whether such fungi are primarily responsible for or a consequence of ineffective airway inflammation is important for future therapeutics development...
  54. pmc Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia 06126, Italy
    J Exp Med 206:2511-26. 2009
    ....
  55. pmc IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS Pathog 9:e1003486. 2013
    ..Thus, IL-22 and IDO1 are crucial in balancing resistance with tolerance to Candida, their deficiencies are risk factors for RVVC, and targeting tolerance via therapeutic kynurenines may benefit patients with RVVC. ..
  56. ncbi request reprint Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism
    Luigina Romani
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Trends Microbiol 14:183-9. 2006
    ..T-reg cells, however, might also represent an additional mechanistic level at which host responses are subverted by fungi...
  57. ncbi request reprint CTLA-4, T helper lymphocytes and dendritic cells: an internal perspective of T-cell homeostasis
    Ursula Grohmann
    Department of Experimental Medicine, Via del Giochetto, University of Perugia, 06126 Perugia, Italy
    Trends Mol Med 9:133-5. 2003
    ....
  58. ncbi request reprint The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans
    Luigina Romani
    Department of Experimental Medicine and Biochemical Science, University of Perugia, 06122 Perugia, Italy
    Int Immunol 16:149-61. 2004
    ..albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development...
  59. pmc Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8 Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3)
    Maria T Pallotta
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Int J Tryptophan Res 3:91-7. 2010
    ..These studies support the finding that IDO is regulated by proteasomal degradation in response to immunogenic and inflammatory stimuli...
  60. ncbi request reprint Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06122, Italy
    Int Immunol 14:65-8. 2002
    ..Therefore, in the mouse, CD8 alpha(+) DC may be unique APC capable of fully expressing the IDO mechanism functionally...
  61. doi request reprint Sensing of mammalian IL-17A regulates fungal adaptation and virulence
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06122, Italy
    Nat Commun 3:683. 2012
    ..This might exemplify a mechanism whereby fungi have evolved a means of sensing host immunity to ensure their own persistence in an immunologically dynamic environment...
  62. ncbi request reprint Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hosts
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Opin Microbiol 6:338-43. 2003
    ..The fitness of the fungus in vivo probably reflects its adaptation to the variety of microenvironments in which this opportunist must survive...
  63. ncbi request reprint Toll-like receptor 9-mediated induction of the immunosuppressive pathway of tryptophan catabolism
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 36:8-11. 2006
    ..At the same time, these studies may offer novel opportunities for use of CpG-ODN as immunosuppressive agents and may also lead to an improved understanding of the cellular events mediated by Toll-like receptor 9 signaling...
  64. ncbi request reprint Fungi, dendritic cells and receptors: a host perspective of fungal virulence
    Luigina Romani
    Dept of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Italy
    Trends Microbiol 10:508-14. 2002
    ....