- Pradotto L, Azan G, Doriguzzi C, Valentini C, Mauro A. Sporadic vascular dementia as clinical presentation of a new missense mutation within exon 7 of NOTCH3 gene. J Neurol Sci. 2008;271:207-10 pubmed publisher..Our finding suggests CADASIL diagnosis must be considered in patients with vascular dementia also in absence of stroke-like events and of family history. ..