Piero Portincasa

Summary

Country: Italy

Publications

  1. ncbi request reprint Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis
    Ignazio Grattagliano
    Department of Internal Medicine and Public Medicine, University Medical School of Bari, Clinica Medica A Murri, 70124 Bari, Italy
    J Nutr Biochem 19:491-504. 2008
  2. ncbi request reprint Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management
    Piero Portincasa
    Department of Internal Medicine and Public Medicine, Clinica Medica A Murri, University Medical School of Bari, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Clin Biochem 38:203-17. 2005
  3. ncbi request reprint Parallel intestinal and liver injury during early cholestasis in the rat: modulation by bile salts and antioxidants
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University of Bari Medical School, Policlinico, 70124 Bari, Italy
    Free Radic Biol Med 42:1381-91. 2007
  4. pmc A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Interdisciplinary Medicine, University of Bari, 70124 Bari, Italy
    World J Gastroenterol 19:3007-17. 2013
  5. ncbi request reprint Mutual changes of thioredoxin and nitrosothiols during biliary cirrhosis: results from humans and cholestatic rats
    Ignazio Grattagliano
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine DIMIMP, University of Bari, Bari, Italy
    Hepatology 45:331-9. 2007
  6. ncbi request reprint Glutathione peroxidase, thioredoxin, and membrane protein changes in erythrocytes predict ribavirin-induced anemia
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italy
    Clin Pharmacol Ther 78:422-32. 2005
  7. doi request reprint Liver function as assessed by breath tests in patients with hepatocellular carcinoma
    Vincenzo O Palmieri
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University of Bari Medical School, Bari, Italy
    J Surg Res 157:199-207. 2009
  8. ncbi request reprint Taurodeoxycholate-induced intestinal injury is modulated by oxidative stress-dependent pre-conditioning like mechanisms
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal and Public Medicine, University of Bari, Piazza G Cesare, 11 70124 Bari, Italy
    Toxicol Lett 182:36-41. 2008
  9. doi request reprint Water channel proteins in bile formation and flow in health and disease: when immiscible becomes miscible
    Piero Portincasa
    University of Bari Medical School, Clinica Medica A Murri, Department of Biomedical Sciences and Human Oncology, Policlinico Hospital, 70124 Bari, Italy
    Mol Aspects Med 33:651-64. 2012
  10. pmc Managing nonalcoholic fatty liver disease: recommendations for family physicians
    Ignazio Grattagliano
    Department of Internal Medicine and Public Medicine, University of Bari, P zza G Cesare, 11 70124 Bari, Italy
    Can Fam Physician 53:857-63. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis
    Ignazio Grattagliano
    Department of Internal Medicine and Public Medicine, University Medical School of Bari, Clinica Medica A Murri, 70124 Bari, Italy
    J Nutr Biochem 19:491-504. 2008
    ..This review mechanistically focused on oxidative stress events leading to individual disease factor appearance in metabolic syndrome patients and their setting for a more helpful clinical approach...
  2. ncbi request reprint Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management
    Piero Portincasa
    Department of Internal Medicine and Public Medicine, Clinica Medica A Murri, University Medical School of Bari, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Clin Biochem 38:203-17. 2005
    ..A better understanding of various pathogenic aspects of NASH will help in identifying potential therapeutic approaches in these patients...
  3. ncbi request reprint Parallel intestinal and liver injury during early cholestasis in the rat: modulation by bile salts and antioxidants
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University of Bari Medical School, Policlinico, 70124 Bari, Italy
    Free Radic Biol Med 42:1381-91. 2007
    ..In conclusion, short-term cholestasis results in distinctive functional, oxidative, and morphological changes of intestinal mucosa, determined increased vulnerability to toxic injury, and parallel hepatic oxidative damage...
  4. pmc A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Interdisciplinary Medicine, University of Bari, 70124 Bari, Italy
    World J Gastroenterol 19:3007-17. 2013
    ..To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes...
  5. ncbi request reprint Mutual changes of thioredoxin and nitrosothiols during biliary cirrhosis: results from humans and cholestatic rats
    Ignazio Grattagliano
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine DIMIMP, University of Bari, Bari, Italy
    Hepatology 45:331-9. 2007
    ..The increase of hepatic, mitochondrial, and circulating nitrosothiols with ongoing cholestasis suggests an active participation of NO in both liver injury and extrahepatic changes...
  6. ncbi request reprint Glutathione peroxidase, thioredoxin, and membrane protein changes in erythrocytes predict ribavirin-induced anemia
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italy
    Clin Pharmacol Ther 78:422-32. 2005
    ..Low erythrocyte membrane protein sulfhydril concentrations are a risk factor for ribavirin-induced anemia. We further studied the role of oxidative stress and erythrocyte membrane alterations in ribavirin-induced anemia...
  7. doi request reprint Liver function as assessed by breath tests in patients with hepatocellular carcinoma
    Vincenzo O Palmieri
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University of Bari Medical School, Bari, Italy
    J Surg Res 157:199-207. 2009
    ..Little is known on hepatic function in patients with hepatocellular carcinoma (HCC). Metabolic changes were explored in HCC patients before/after nonsurgical therapy...
  8. ncbi request reprint Taurodeoxycholate-induced intestinal injury is modulated by oxidative stress-dependent pre-conditioning like mechanisms
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal and Public Medicine, University of Bari, Piazza G Cesare, 11 70124 Bari, Italy
    Toxicol Lett 182:36-41. 2008
    ....
  9. doi request reprint Water channel proteins in bile formation and flow in health and disease: when immiscible becomes miscible
    Piero Portincasa
    University of Bari Medical School, Clinica Medica A Murri, Department of Biomedical Sciences and Human Oncology, Policlinico Hospital, 70124 Bari, Italy
    Mol Aspects Med 33:651-64. 2012
    ..Involvement of aquaporins in a series of clinically relevant hepatobiliary disorders are also discussed...
  10. pmc Managing nonalcoholic fatty liver disease: recommendations for family physicians
    Ignazio Grattagliano
    Department of Internal Medicine and Public Medicine, University of Bari, P zza G Cesare, 11 70124 Bari, Italy
    Can Fam Physician 53:857-63. 2007
    ..To review evidence on the diagnosis and management of nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease in human beings...
  11. doi request reprint Coordinate regulation of gallbladder motor function in the gut-liver axis
    Piero Portincasa
    Department of Internal Medicine and Public Medicine, Clinica Medica A Murri, University of Bari Medical School, Bari, Italy
    Hepatology 47:2112-26. 2008
    ..Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation...
  12. doi request reprint Oxidized LDL receptor 1 gene polymorphism in patients with metabolic syndrome
    Vincenzo O Palmieri
    Department of Biomedical Sciences and Human Oncology, Clinica Medica A Murri, University of Bari, Bari, Italy
    Eur J Clin Invest 43:41-8. 2013
    ..We therefore evaluated the genotyping of OLR1 gene in a sample of 55 patients with Metabolic Syndrome, a clinical condition characterized by a high cardiovascular risk...
  13. ncbi request reprint Modulation of cholesterol crystallization in bile. Implications for non-surgical treatment of cholesterol gallstone disease
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine DIMIMP, University Medical School, Bari, Italy
    Curr Drug Targets Immune Endocr Metabol Disord 5:177-84. 2005
    ..Recent advances on the role of ursodeoxycholate as an agent preventing the precipitation of cholesterol crystals in bile will be highligthed...
  14. ncbi request reprint Targeting the liver in the metabolic syndrome: evidence from animal models
    Michele Petruzzelli
    Clinica Medica A Murri, University of Bari, Italy
    Curr Pharm Des 13:2199-207. 2007
    ....
  15. ncbi request reprint Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine DIMIMP, University of Bari, P zza G Cesare, 11, 70124 Bari, Italy
    Exp Gerontol 39:1323-32. 2004
    ..Both interventions reduced the age-associated increase of GSH-Px and protein carbonyls and improved mitochondrial respiration...
  16. ncbi request reprint Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs: role of bile salts
    Michele Petruzzelli
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine DIMIMP, University Medical School of Bari, Italy
    Clin Biochem 40:503-10. 2007
    ..What is in bile that could play a role in NSAID toxicity? This timely review will critically discuss the role of bile salts in NSAID-dependent gut damage...
  17. ncbi request reprint Current pharmacological treatment of nonalcoholic fatty liver
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine DIMIMP, University Medical School, Bari, Italy
    Curr Med Chem 13:2889-900. 2006
    ..In this review, after summarizing the general background on fatty liver, the most current and attractive pharmacological approaches to the problem of NAFLD/NASH are discussed...
  18. ncbi request reprint Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome
    Vincenzo O Palmieri
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University Medical School of Bari, Bari, Italy
    J Nutr 136:3022-6. 2006
    ....
  19. doi request reprint Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation
    Ignazio Grattagliano
    Department of Interdisciplinary Medicine, Clinica Medica A Murri, University of Bari Medical School, Bari, Italy
    Clin Biochem 45:610-8. 2012
    ..Mitochondria play a major role in cell energy-generating processes and integrate several signalling pathways to control cellular life and death...
  20. doi request reprint Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients
    Ignazio Grattagliano
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University Medical School of Bari, Bari, Italy
    Clin Biochem 44:1400-4. 2011
    ..Cholestasis is associated with systemic and hepatic oxidative and nitrosative stress; in this scenario, the conjugated hydrophilic bile salt ursodeoxycholate (UDCA) might play a protective role...
  21. doi request reprint 13C-breath tests for clinical investigation of liver mitochondrial function
    Ignazio Grattagliano
    Clinica Medica A Murri, Department of Internal Medicine, University of Bari Medical School, Bari, Italy
    Eur J Clin Invest 40:843-50. 2010
    ....
  22. ncbi request reprint The "hemolysis model" for the study of cyto-toxicity and cyto-protection by bile salts and phospholipids
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal and Public Medicine, University Medical School, Piazza G Cesare 11, 70124 Bari, Italy
    Adv Exp Med Biol 578:93-9. 2006
  23. ncbi request reprint Non-alcoholic fatty liver disease in the metabolic syndrome
    Giuseppe Palasciano
    Clinica Medica A Murri, Department of Internal and Public Medicine, University of Bari, Bari, Italy
    Curr Pharm Des 13:2193-8. 2007
    ..Novel diagnostic tools and life style modifications together with targeted therapeutic actions are urgently needed for the management of liver dysfunction in course of metabolic syndrome...
  24. doi request reprint T16189C mitochondrial DNA variant is associated with metabolic syndrome in Caucasian subjects
    Vincenzo Ostilio Palmieri
    Department of Internal Medicine and Public Medicine, Clinica Medica A Murri, University of Bari, Bari, Italy
    Nutrition 27:773-7. 2011
    ..Our aim was to verify the T4291C and T16189C variants in subjects affected by different phenotypes of MS...
  25. ncbi request reprint Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Sci (Lond) 111:135-43. 2006
    ..In conclusion, both microsomal and mitochondrial functions are disturbed in NASH. Therefore stable isotope breath tests may usefully contribute to a better and non-invasive characterization of patients with NAFLD...
  26. ncbi request reprint The emerging problem of nonalcoholic steatohepatitis (NASH)
    Piero Portincasa
    Clinica Medica Augusto Murri, Dept of Internal Medicine and Public Medicine, University Medical School of Bari, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Rom J Gastroenterol 14:43-51. 2005
    ..This article focus on current thoughts on the natural history and clinical presentation of NASH and describes current trends in the diagnosis and treatment of this emerging condition...
  27. ncbi request reprint Improving nonalcoholic fatty liver disease management by general practitioners: a critical evaluation and impact of an educational training program
    Ignazio Grattagliano
    General Medicine and Primary Care, Department of Internal and Public Medicine, University Medical School of Bari, Piazza G Cesare 11, 73124 Bari, Italy
    J Gastrointestin Liver Dis 17:389-94. 2008
    ..This study aimed to assess GPs' knowledge and practice and a training project impact about NAFLD:..
  28. ncbi request reprint Contribution of canalicular glutathione efflux to bile formation. From cholestasis associated alterations to pharmacological intervention to modify bile flow
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University Medical School of Bari, Italy
    Curr Drug Targets Immune Endocr Metabol Disord 5:153-61. 2005
    ..Novel findings on the role of water channels and of the multidrug resistant proteins in bile salt-independent bile formation, will also be discussed. New routes of intervention to modify bile flow for therapeutic purposes are considered...
  29. doi request reprint Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options
    Leonilde Bonfrate
    Department of Biomedical Sciences and Human Oncology DIMO, Clinica Medica A Murri, University of Bari Medical School, Bari, Italy
    Scand J Gastroenterol 48:995-1009. 2013
    ..Initial therapeutic approaches in IBS have focused on microbiota. The relationship between perturbations of the microbiota, mucosal inflammation and IBS remains to be further investigated...
  30. ncbi request reprint Assessing gastrointestinal symptoms and perception, quality of life, motility, and autonomic neuropathy in clinical studies
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal Medicine and Public Medicine, University of Bari Medical School, Bari, Italy
    J Gastrointestin Liver Dis 18:205-11. 2009
    ..In the present review, the state-of-the-art methods for correct assessment of several factors regarding the onset, perpetuation and outcome of functional GI diseases are discussed...
  31. ncbi request reprint Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italy
    Hepatology 39:1248-55. 2004
    ..In vitro, GSHE and DPD reduce the RBV-associated oxidative stress in erythrocytes and prevent the increase in osmotic fragility, suggesting that these compounds might decrease the risk of hemolysis in patients...
  32. ncbi request reprint Impaired gallbladder motility and delayed orocecal transit contribute to pigment gallstone and biliary sludge formation in beta-thalassemia major adults
    Piero Portincasa
    Section of Internal Medicine, Department of Internal and Public Medicine, University Medical School of Bari, P zza G Cesare 11, 70124 Bari, Italy
    World J Gastroenterol 10:2383-90. 2004
    ..To investigated the role of gallbladder and gastrointestinal motility disorders in pigment gallstone formation in beta-thalassemia major...
  33. ncbi request reprint MicroRNA in colorectal cancer: new perspectives for diagnosis, prognosis and treatment
    Leonilde Bonfrate
    Clinica Medica A Murri, Department of Biomedical Sciences and Human Oncology, Aldo Moro University Medical School Bari, Italy
    J Gastrointestin Liver Dis 22:311-20. 2013
    ..Before miRNAs can become available in the clinical setting, however, a number of large prospective studies are still required. ..
  34. ncbi request reprint Defective in vitro contractility of ureteropelvic junction in children with functional and obstructive urine flow impairment
    Piero Portincasa
    Clinica Medica A Murri, Department of Internal and Public Medicine, University of Bari, 70100 Bari, Italy
    J Pediatr Surg 41:1594-7. 2006
    ..Muscle function, however, has not been investigated. We therefore evaluated in vitro UPJ contractility by tensiometry in children with UFI...
  35. pmc A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways
    Gabriella Garruti
    Section of Endocrinology, Department of Emergency and Organ Transplantations, University of Bari Aldo Moro Medical School, Piazza G Cesare 11, 70124 Bari, Italy
    J Lipids 2012:304292. 2012
    ..Current understanding about the pleiotropic role of SHP is examined in this paper, and principal metabolic aspects connected with SHP function will be also discussed...
  36. ncbi request reprint Mitochondrial glutathione content determines the rate of liver regeneration after partial hepatectomy in eu- and hypothyroid rats
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Piazza G Cesare, 11 70124 Bari, Italy
    J Hepatol 39:571-9. 2003
    ..Mitochondrial glutathione has been postulated to affect mitochondrial function and liver regeneration...
  37. ncbi request reprint Adefovir dipivoxyl for the treatment of delta-related liver cirrhosis
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University Medical School of Bari, Bari, Italy
    Ann Pharmacother 40:1681-4. 2006
    ..To report a case suggesting the beneficial effect of adefovir dipivoxyl in patients with delta-related decompensated liver cirrhosis ineffectively treated with lamivudine...
  38. ncbi request reprint Esomeprazole-induced central fever with severe myalgia
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University Medical School of Bari, Bari, Italy
    Ann Pharmacother 39:757-60. 2005
    ..To report a case of central fever associated with severe myalgia following esomeprazole...
  39. ncbi request reprint From lipid secretion to cholesterol crystallization in bile. Relevance in cholesterol gallstone disease
    Piero Portincasa
    Department of Internal Medicine and Public Medicine, University Medical School, Bari, Italy
    Ann Hepatol 1:121-8. 2002
    ..Essential topics reviewed here deal with pathways of biliary lipid secretion, cholesterol solubilization and crystallization in bile, according to recent advances. Main in vivo events in cholesterol gallstone disease are also described...
  40. doi request reprint Familial mediterranean fever: a fascinating model of inherited autoinflammatory disorder
    Piero Portincasa
    Clinica Medica A Murri, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Eur J Clin Invest 43:1314-27. 2013
    ..Novel drugs are emerging, allowing better management of colchicine-resistant/colchicine-intolerant patients. This review aims to attract the attention of the readers on differential diagnosis and management of patients with FMF...
  41. pmc Therapy of gallstone disease: What it was, what it is, what it will be
    Piero Portincasa
    Piero Portincasa, Leonilde Bonfrate, Department of Biomedical Sciences and Human Oncology, Clinica Medica A Murri, University of Bari Medical School, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    World J Gastrointest Pharmacol Ther 3:7-20. 2012
    ..In this review we discuss old, recent and future perspectives on medical treatment of cholesterol cholelithiasis...
  42. ncbi request reprint Water handling and aquaporins in bile formation: recent advances and research trends
    Piero Portincasa
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, Medical School, University of Bari, Bari, Italy
    J Hepatol 39:864-74. 2003
  43. ncbi request reprint Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    Biochim Biophys Acta 1767:1260-7. 2007
    ..It is concluded that CD diet causes mitochondrial complex I dysfunction which can be attributed to ROS-induced cardiolipin oxidation. These findings provide new insights into the alterations underlying mitochondrial dysfunction in NAFLD...
  44. ncbi request reprint Non-alcoholic steatohepatitis (NASH): approaching more tailored and effective therapies
    Piero Portincasa
    J Gastrointestin Liver Dis 16:167-9. 2007
  45. ncbi request reprint Overview on the mechanisms of drug-induced liver cell death
    Ignazio Grattagliano
    Department of Internal Medicine and Public Medicine DIMIMP, University Medical School, Bari, Italy
    Ann Hepatol 1:162-8. 2002
    ..Finally, the role of both mitochondria and non parenchymal cells are reviewed with respect to approaches useful to manage drug-induced liver injury...
  46. ncbi request reprint Present and future therapeutic strategies in non-alcoholic fatty liver disease
    Giuseppe Calamita
    Department of General and Environmental Physiology, University of Bari, Italy
    Expert Opin Ther Targets 11:1231-49. 2007
    ..Although no established therapy exists for NAFLD/NASH, potential therapeutic approaches are discussed in this review...
  47. pmc Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 134:2101-10. 2008
    ....